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https://www.readbyqxmd.com/read/29769440/elevated-hepatic-expression-of-h19-long-noncoding-rna-contributes-to-diabetic-hyperglycemia
#1
Na Zhang, Tingting Geng, Zhangsheng Wang, Ruling Zhang, Tiefeng Cao, Joao Paulo Camporez, Shi-Ying Cai, Ya Liu, Luisa Dandolo, Gerald I Shulman, Gordon G Carmichael, Hugh S Taylor, Yingqun Huang
Excessive hepatic glucose production (HGP) contributes significantly to the hyperglycemia of type 2 diabetes; however, the molecular mechanism underlying this dysregulation remains poorly understood. Here, we show that fasting temporally increases the expression of H19 long noncoding RNA (lncRNA) in nondiabetic mouse liver, whereas its level is chronically elevated in diet-induced diabetic mice, consistent with the previously reported chronic hepatic H19 increase in diabetic patients. Importantly, liver-specific H19 overexpression promotes HGP, hyperglycemia, and insulin resistance, while H19 depletion enhances insulin-dependent suppression of HGP...
May 17, 2018: JCI Insight
https://www.readbyqxmd.com/read/29750294/lncrna-uc-48-is-involved-in-the-diabetic-immune-and-inflammatory-responses-mediated-by-p2x7-receptor-in-raw264-7-macrophages
#2
Hong Wu, Fang Wen, Mei Jiang, Qiang Liu, Yijun Nie
High glucose combined with high FFAs can contribute to the unfavorable development of type 2 diabetes mellitus (T2DM) and monocytes/macrophages are important in the occurrence and development of T2DM, which is regarded as a type of low‑grade inflammation. Although our previous study demonstrated that increased expression of P2X7 receptor (P2X7R) in peripheral blood monocytes may alter the innate immune system and that long non‑coding (lnc)RNA uc.48+ was involved in diabetic neuropathic pain, the involvement of uc...
May 9, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29719408/role-of-digeorge-syndrome-critical-region-gene-9-a-long-noncoding-rna-in-gastric-cancer
#3
Chao Ni, Ping Yang, Junming Guo, Meng Ye
Introduction: Long non-coding RNAs (lncRNAs) regulate and influence cancer cell development and tumor formation. However, the role for lncRNAs in gastric cancer has not been fully established. In this study, DGCR9 , a lncRNA, was significantly upregulated in gastric cancer cell lines. Methods: The expression levels of DGCR9 in each patient between formalin-fixed, paraffin-embedded (FFPE) gastric cancer tissues and adjacent noncancer tissues (NAT) (n=102) were measured by quantitative reverse-transcription polymerase chain reaction (qRT-PCR)...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29695738/malat1-an-epigenetic-regulator-of-inflammation-in-diabetic-retinopathy
#4
Saumik Biswas, Anu Alice Thomas, Shali Chen, Erfan Aref-Eshghi, Biao Feng, John Gonder, Bekim Sadikovic, Subrata Chakrabarti
Despite possessing limited protein-coding potential, long non-coding RNAs (lncRNAs) have been implicated in a myriad of pathologic conditions. Most well documented in cancer, one prominent intergenic lncRNA known as MALAT1 is notorious for its role in impacting epigenetic mechanisms. In this study, we established a novel epigenetic paradigm for MALAT in diabetic retinopathy (DR) by employing siRNA-mediated MALAT1 knockdown in human retinal endothelial cells (HRECs), a Malat1 knockout animal model, vitreous humor from diabetic patients, pharmacological inhibitors for histone and DNA methylation, RNA immunoprecipitation, western blotting, and a unique DNA methylation array to determine glucose-related alterations in MALAT1...
April 25, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29663500/knockdown-of-lncrna-uca1-suppresses-chemoresistance-of-pediatric-aml-by-inhibiting-glycolysis-through-the-microrna-125a-hexokinase-2-pathway
#5
Yuan Zhang, Yufeng Liu, Xueju Xu
Dysregulation of lncRNAs is implicated in chemoresistance in varieties of tumor including acute myeloid leukemia (AML). LncRNA urothelial carcinoma-associated 1 (UCA1) was reported to play an oncogenic role in AML. However, whether UCA1 was involved in chemoresistance in pediatric AML remains unclear. UCA1 expression in AML patients after adriamycin (ADR)-based chemotherapy and ADR-resistant AML cells was examined by qRT-PCR. The effects of UCA1 on the cytotoxicity of ADR and glycolysis were evaluated by MTT assay and measuring the glucose consumption and lactate production in HL60 and HL60/ADR cells, repectively...
April 16, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29600544/down-regulated-long-non-coding-rna-anril-restores-the-learning-and-memory-abilities-and-rescues-hippocampal-pyramidal-neurons-from-apoptosis-in-streptozotocin-induced-diabetic-rats-via-the-nf-%C3%AE%C2%BAb-signaling-pathway
#6
Xin Wen, Xin-Rui Han, Yong-Jian Wang, Shan Wang, Min Shen, Zi-Feng Zhang, Shao-Hua Fan, Qun Shan, Liang Wang, Meng-Qiu Li, Bin Hu, Chun-Hui Sun, Dong-Mei Wu, Jun Lu, Yuan-Lin Zheng
Diabetes often causes learning and memory deficits, which leads to unfavorable behavioral performance. In this study, we investigated the effects of long non-coding RNA (lncRNA) ANRIL on learning, memory abilities, and hippocampal neuronal apoptosis via the NF-κB signaling pathway in streptozotocin (STZ)-induced diabetic rats. After successful establishment of diabetic rat models, the subjects were then assigned into the DM, DM + si-ANRIL, DM + si-negative control (si-NC) groups, as well as an additional normal group...
March 30, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29590649/circulating-lncrnas-analysis-in-patients-with-type-2-diabetes-reveals-novel-genes-influencing-glucose-metabolism-and-islet-%C3%AE-cell-function
#7
Yuting Ruan, Nie Lin, Qiang Ma, Rongping Chen, Zhen Zhang, Weiheng Wen, Hong Chen, Jia Sun
BACKGROUND/AIMS: The islet is an important endocrine organ to secrete insulin to regulate the metabolism of glucose and maintain the stability of blood glucose. Long noncoding RNAs (lncRNAs) are involved in a variety of biological functions and play key roles in many diseases, including type 2 diabetes (T2D). The aim of this study was to determine whether lncRNA-p3134 is associated with glucose metabolism and insulin signaling in pancreatic β cells. METHODS: LncRNA microarray technology was used to identify the differentially expressed circulating lncRNAs in T2D patients...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29577871/long-noncoding-rna-malat1-regulates-generation-of-reactive-oxygen-species-and-the-insulin-responses-in-male-mice
#8
Jingshu Chen, Sui Ke, Lei Zhong, Jing Wu, Alexander Tseng, Benjamin Morpurgo, Andrei Golovko, Gang Wang, James J Cai, Xi Ma, Defa Li, Yanan Tian
The metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a long noncoding RNA and its overexpression is associated with the development of many types of malignancy. MALAT1 null mice show no overt phenotype. However, in transcriptome analysis of MALAT1 null mice we found significant upregulation of nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) regulated antioxidant genes including Nqo1 and Cat with significant reduction in reactive oxygen species (ROS) and greatly reduced ROS-generated protein carbonylation in hepatocyte and islets...
March 22, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29575939/mechanism-of-malat1-preventing-apoptosis-of-vascular-endothelial-cells-induced-by-oxygen-glucose-deficiency-and-reoxidation
#9
Guoping Wang, Yuanbo Wu, Yuyou Zhu
BACKGROUND: Cerebral ischemia/reperfusion (I/R) injury leads to cerebrovascular dysfunction characterized by endothelial cell injury or death. Metastasis-associated lung adenocarcinoma transcript 1(MALAT1) has been reported to be associated with endothelial dysfunction. Our study aimed to investigate the effect of MALAT1 on vascular endothelium. METHODS: In this study, oxygen-glucose deprivation and reoxygenation (OGD-R) were used as in vitro studies to investigate the role of MALAT1 in I/R-induced apoptosis of cerebrovascular endothelial cells in an I/R injury model...
March 26, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29501744/lncrna-pdia3p-interacts-with-c-myc-to-regulate-cell-proliferation-via-induction-of-pentose-phosphate-pathway-in-multiple-myeloma
#10
Xiangchou Yang, Haihao Ye, Muqing He, Xiaohai Zhou, Ni Sun, Wenjian Guo, Xiaoji Lin, He Huang, Ying Lin, Rongxin Yao, Hong Wang
Multiple myeloma (MM), the second most common hematologic malignancy, is an incurable disease characterized by the accumulation of malignant plasma cells within the bone marrow. Though great progresses have been made in understanding the mechanisms of MM, metabolic plasticity and drug resistance remain largely unknown. In this study, we found lncRNA Protein disulfide isomerase family A member 3 pseudogene 1 (PDIA3P) is highly expressed in MM and is associated with the survival rate of MM patients. PDIA3P regulates MM growth and drug resistance through Glucose 6-phosphate dehydrogenase (G6PD) and the pentose phosphate pathway (PPP)...
March 25, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29436679/long-non%C3%A2-coding-rna-bc168687-small-interfering-rna-reduces-high-glucose-and-high-free-fatty-acid%C3%A2-induced-expression-of-p2x7-receptors-in-satellite-glial-cells
#11
Cheng-Long Liu, Ze-Yu Deng, Er-Rong Du, Chang-Shui Xu
Purinergic signaling contributes to inflammatory and immune responses. The activation of the P2X purinoceptor 7 (P2X7) in satellite glial cells (SGCs) may be an essential component in the promotion of inflammation and neuropathic pain. Long non‑coding RNAs (lncRNAs) are involved in multiple physiological and pathological processes. The aim of the present study was to investigate the effects of a small interfering RNA for the lncRNA BC168687 on SGC P2X7 expression in a high glucose and high free fatty acids (HGHF) environment...
April 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29414510/adiponectin-as-lncrna-inhibits-adipogenesis-by-transferring-from-nucleus-to-cytoplasm-and-attenuating-adiponectin-mrna-translation
#12
Rui Cai, Yunmei Sun, Naren Qimuge, Guoqiang Wang, Yingqian Wang, Guiyan Chu, Taiyong Yu, Gongshe Yang, Weijun Pang
Adiponectin (AdipoQ) is an adipocyte-derived hormone with positive function on systemic glucose and lipid metabolism. Long noncoding RNA (lncRNA) is emerging as a vital regulator of adipogenesis. However, AdipoQ-related lncRNAs in lipid metabolism have not been explored. Here, AdipoQ antisense (AS) lncRNA was first identified, and we further found that it inhibited adipogenesis. The half-life of AdipoQ AS lncRNA was 10 h, whereas that of AdipoQ mRNA was 4 h. During adipogenic differentiation, AdipoQ AS lncRNA translocated from nucleus to cytoplasm...
April 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29382663/long-noncoding-rna-lncshgl-recruits-hnrnpa1-to-suppress-hepatic-gluconeogenesis-and-lipogenesis
#13
Junpei Wang, Weili Yang, Zhenzhen Chen, Ji Chen, Yuhong Meng, Biaoqi Feng, Libo Sun, Lin Dou, Jian Li, Qinghua Cui, Jichun Yang
Mammalian genomes encode a huge number of long noncoding RNAs (lncRNAs) with unknown functions. This study determined the role and mechanism of a new lncRNA, lncRNA suppressor of hepatic gluconeogenesis and lipogenesis (lncSHGL), in regulating hepatic glucose/lipid metabolism. In the livers of obese mice and patients with nonalcoholic fatty liver disease, the expression levels of mouse lncSHGL and its human homologous lncRNA B4GALT1-AS1 were reduced. Hepatic lncSHGL restoration improved hyperglycemia, insulin resistance, and steatosis in obese diabetic mice, whereas hepatic lncSHGL inhibition promoted fasting hyperglycemia and lipid deposition in normal mice...
April 2018: Diabetes
https://www.readbyqxmd.com/read/29377234/lncrna-snhg1-regulates-cerebrovascular-pathologies-as-a-competing-endogenous-rna-through-hif-1%C3%AE-vegf-signaling-in-ischemic-stroke
#14
Lin Zhang, Xianliang Luo, Feng Chen, Wei Yuan, Xinli Xiao, Xiaohua Zhang, Yaru Dong, Yuanxiao Zhang, Yong Liu
Studies have shown that long noncoding ribonucleic acids (lncRNAs) play critical roles in multiple biologic processes. However, the Small Nucleolar RNA Host Gene 1 (SNHG1) function and underlying molecular mechanisms in ischemic stroke have not yet been reported. In the present study, we found that SNHG1 expression was remarkably increased both in isolated cerebral micro-vessels of a middle cerebral artery occlusion (MCAO) mice model, and in oxygen-glucose deprivation (OGD)-cultured mice brain micro-vascular endothelial cells (BMECs), meanwhile, the SNHG1 level was negatively correlated with miR-18a in MCAO mice...
January 27, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29363576/the-long-non-coding-rna-gm10768-activates-hepatic-gluconeogenesis-by-sequestering-microrna-214-in-mice
#15
Xianwei Cui, Jingmin Tan, Yujie Shi, Chen Sun, Yun Li, Chenbo Ji, Jun Wu, Zhao Zhang, Siyu Chen, Xirong Guo, Chang Liu
Overactivated hepatic gluconeogenesis contributes to the pathogenesis of metabolic disorders, including type 2 diabetes. Precise control of hepatic gluconeogenesis is thus critical for maintaining whole-body metabolic homeostasis. Long non-coding RNAs (lncRNAs) have been shown to play key roles in diseases by regulating diverse biological processes, but the function of lncRNAs in maintaining normal physiology, particularly glucose homeostasis in the liver, remains largely unexplored. We identified a novel liver-enriched long non-coding RNA, Gm10768, and examined its expression patterns under pathophysiological conditions...
March 16, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29350287/long-non-coding-rna-h19-promotes-glucose-metabolism-and-cell-growth-in-malignant-melanoma-via-mir-106a-5p-e2f3-axis
#16
Wenkang Luan, Zhou Zhou, Xin Ni, Yun Xia, Jinlong Wang, Yulan Yan, Bin Xu
PURPOSE: lncRNA H19 has been considered as an oncogenic lncRNA in many human tumours. In the present study, we identify the role and molecular mechanism of lncRNA H19 in melanoma. METHOD: QRT-PCR was used to detect the expression of lncRNA H19 and E2F3 was detected in melanoma tissues. Cell counting kit-8 (CCK8), representative metabolites analysis was used to explore the biological function of lncRNA H19, miR-106a-5p and E2F3 in melanoma cells. Bioinformatics, luciferase reporter assays, MS2-RIP and RNA pull-down assay was used to demonstrate the molecular mechanism of lncRNA H19 in melanoma...
March 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29317209/lncrna-malat1-is-up-regulated-in-diabetic-gastroparesis-and-involved-in-high-glucose-induced-cellular-processes-in-human-gastric-smooth-muscle-cells
#17
Yaoyao Gong, Ying Zhu, Boqian Zhu, Xinmin Si, Ding Heng, Yurong Tang, Xiaomeng Sun, Lin Lin
Recent years, widespread long non-coding RNAs (lncRNAs) were identified and known as regulator of gene expression. Diabetic gastroparesis (DGP) is one of the most common chronic complications of diabetes mellitus. There was no research reported the role of lncRNAs in DGP. In this study, we firstly established a rat model of DGP by STZ injection. Then, we detected the expression of MALAT1 and found that expression of MALAT1 was up-regulated in rat model of DGP, comparing to the control group (P < .01)...
February 5, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29258823/long-non-coding-rna-rmst-silencing-protects-against-middle-cerebral-artery-occlusion-mcao-induced-ischemic-stroke
#18
Xiao-Xia Hou, Hong Cheng
Long non-coding RNAs (lncRNAs) have emerged as major regulators in neurological diseases, and clarifying their roles in cerebral ischemic injury may provide novel targets for treating ischemic stroke. In this study, we mainly studied the role of lncRNA-RMST in middle cerebral artery occlusion (MCAO)-induced mouse brain injury. We showed that RMST expression level was significantly up-regulated in oxygen-glucose deprivation (OGD)-treated primary hippocampal neuron, MCAO-induced injured brain, and the plasma of patients with ischemic stroke...
January 22, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29238035/long-non-coding-rna-meg3-functions-as-a-competing-endogenous-rna-to-regulate-ischemic-neuronal-death-by-targeting-mir-21-pdcd4-signaling-pathway
#19
Honglin Yan, Jie Rao, Jingping Yuan, Likun Gao, Wenxian Huang, Lina Zhao, Jiacai Ren
Long non-coding RNA (lncRNA) maternally expressed gene 3 (MEG3) has been demonstrated as an important regulator in diverse human cancers. However, its function and regulatory mechanism in ischemic stroke remains largely unknown. Here, we report that MEG3 is physically associated with microRNA-21 (miR-21), while miR-21 is downregulated following ischemia in the ischemic core in vitro and in vivo, which is opposite to MEG3. Besides, overexpression of miR-21 protects oxygen-glucose deprivation and reoxygenation (OGD/R)-induced apoptotic cell death...
December 13, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29204447/effects-of-lncrna-bc168687-sirna-on-diabetic-neuropathic-pain-mediated-by-p2x-7-receptor-on-sgcs-in-drg-of-rats
#20
Chenglong Liu, Jia Tao, Hui Wu, Yixin Yang, Qiang Chen, Zeyu Deng, Jiandi Liu, Changshui Xu
Diabetic neuropathic pain (DNP), one of the early symptoms of diabetic neuropathy, relates to metabolic disorders induced by high blood glucose, neurotrophic vascular ischemia and hypoxia, and autoimmune factors. This study was aimed at exploring the effects of long noncoding RNA (lncRNA) BC168687 siRNA on DNP mediated by P2X7 receptor on SGCs in DRG of rats. The mechanical withdrawal threshold (MWT) and thermal withdrawal latency (TWL) of rats, the expression levels of P2X7 mRNA and protein in the DRG, and nitric oxide (NO) in the serum were, respectively, detected in our study...
2017: BioMed Research International
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