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https://www.readbyqxmd.com/read/29350287/long-non-coding-rna-h19-promotes-glucose-metabolism-and-cell-growth-in-malignant-melanoma-via-mir-106a-5p-e2f3-axis
#1
Wenkang Luan, Zhou Zhou, Xin Ni, Yun Xia, Jinlong Wang, Yulan Yan, Bin Xu
PURPOSE: lncRNA H19 has been considered as an oncogenic lncRNA in many human tumours. In the present study, we identify the role and molecular mechanism of lncRNA H19 in melanoma. METHOD: QRT-PCR was used to detect the expression of lncRNA H19 and E2F3 was detected in melanoma tissues. Cell counting kit-8 (CCK8), representative metabolites analysis was used to explore the biological function of lncRNA H19, miR-106a-5p and E2F3 in melanoma cells. Bioinformatics, luciferase reporter assays, MS2-RIP and RNA pull-down assay was used to demonstrate the molecular mechanism of lncRNA H19 in melanoma...
January 19, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29317209/lncrna-malat1-is-up-regulated-in-diabetic-gastroparesis-and-involved-in-high-glucose-induced-cellular-processes-in-human-gastric-smooth-muscle-cells
#2
Yaoyao Gong, Ying Zhu, Boqian Zhu, Xinmin Si, Ding Heng, Yurong Tang, Xiaomeng Sun, Lin Lin
Recent years, widespread long non-coding RNAs (lncRNAs) were identified and known as regulator of gene expression. Diabetic gastroparesis (DGP) is one of the most common chronic complications of diabetes mellitus. There was no research reported the role of lncRNAs in DGP. In this study, we firstly established a rat model of DGP by STZ injection. Then, we detected the expression of MALAT1 and found that expression of MALAT1 was up-regulated in rat model of DGP, comparing to the control group (P < .01)...
January 6, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29258823/long-non-coding-rna-rmst-silencing-protects-against-middle-cerebral-artery-occlusion-mcao-induced-ischemic-stroke
#3
Xiao-Xia Hou, Hong Cheng
Long non-coding RNAs (lncRNAs) have emerged as major regulators in neurological diseases, and clarifying their roles in cerebral ischemic injury may provide novel targets for treating ischemic stroke. In this study, we mainly studied the role of lncRNA-RMST in middle cerebral artery occlusion (MCAO)-induced mouse brain injury. We showed that RMST expression level was significantly up-regulated in oxygen-glucose deprivation (OGD)-treated primary hippocampal neuron, MCAO-induced injured brain, and the plasma of patients with ischemic stroke...
December 16, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29238035/long-non-coding-rna-meg3-functions-as-a-competing-endogenous-rna-to-regulate-ischemic-neuronal-death-by-targeting-mir-21-pdcd4-signaling-pathway
#4
Honglin Yan, Jie Rao, Jingping Yuan, Likun Gao, Wenxian Huang, Lina Zhao, Jiacai Ren
Long non-coding RNA (lncRNA) maternally expressed gene 3 (MEG3) has been demonstrated as an important regulator in diverse human cancers. However, its function and regulatory mechanism in ischemic stroke remains largely unknown. Here, we report that MEG3 is physically associated with microRNA-21 (miR-21), while miR-21 is downregulated following ischemia in the ischemic core in vitro and in vivo, which is opposite to MEG3. Besides, overexpression of miR-21 protects oxygen-glucose deprivation and reoxygenation (OGD/R)-induced apoptotic cell death...
December 13, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29204447/effects-of-lncrna-bc168687-sirna-on-diabetic-neuropathic-pain-mediated-by-p2x7-receptor-on-sgcs-in-drg-of-rats
#5
Chenglong Liu, Jia Tao, Hui Wu, Yixin Yang, Qiang Chen, Zeyu Deng, Jiandi Liu, Changshui Xu
Diabetic neuropathic pain (DNP), one of the early symptoms of diabetic neuropathy, relates to metabolic disorders induced by high blood glucose, neurotrophic vascular ischemia and hypoxia, and autoimmune factors. This study was aimed at exploring the effects of long noncoding RNA (lncRNA) BC168687 siRNA on DNP mediated by P2X7 receptor on SGCs in DRG of rats. The mechanical withdrawal threshold (MWT) and thermal withdrawal latency (TWL) of rats, the expression levels of P2X7 mRNA and protein in the DRG, and nitric oxide (NO) in the serum were, respectively, detected in our study...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29115403/expression-profile-analysis-of-long-non-coding-rnas-involved-in-the-metformin-inhibited-gluconeogenesis-of-primary-mouse-hepatocytes
#6
Yao Wang, Hongju Tang, Xueying Ji, Yuqing Zhang, Wan Xu, Xue Yang, Ruyuan Deng, Yun Liu, Fengying Li, Xiao Wang, Libin Zhou
Long non-coding RNAs (lncRNAs) have been demonstrated to regulate metabolic tissue development and function, including adipogenesis, hepatic lipid metabolism, islet function and energy balance. However, the role of lncRNAs in gluconeogenesis remains completely unknown. Metformin reduces glucose output mainly via the inhibition of gluconeogenesis. In the present study, the lncRNA expression profile of primary mouse hepatocytes exposed to cyclic adenosine monophosphate (cAMP), a gluconeogenic stimulus, with or without metformin was analyzed by microarray...
November 7, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29110299/long-non-coding-rna-malat1-expression-in-patients-with-gestational-diabetes-mellitus
#7
Yisheng Zhang, Hangyu Wu, Fuyan Wang, Mei Ye, Hong Zhu, Shizhong Bu
OBJECTIVE: To monitor the expression of long non-coding RNAs (lncRNAs) and changes in metabolic profiles among patients with gestational diabetes mellitus (GDM). METHODS: A retrospective case-control study was conducted using data for women treated at a hospital in China between October 8, 2014, and April 15, 2015. Patients diagnosed with GDM using an oral glucose tolerance test at 24-28 weeks of pregnancy (n=50) were included. The control group comprised pregnant women without GDM (n=47)...
November 6, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29101036/profiling-neuron-autonomous-lncrna-changes-upon-ischemia-reperfusion-injury
#8
Li Haiying, Wu Youjia, Suo Guihai, Shen Feifei, Zhen Yuqin, Xia Chen, Lv Haitao
Extensive changes of neuronal transcriptome occur post ischemic stroke and during the following reperfusion. Although numerous studies focused on transcriptome changes of mRNAs associated with ischemic stroke, little is known about whether and how long non-coding RNAs (lncRNAs), which play critical roles in cellular homeostasis, are involved in this process. In this study, we performed high throughput screening to analyze expression changes of lncRNAs in primarily cultured hippocampal neurons under an oxygen-glucose deprivation/reperfusion (OGD/R) condition at 0h, 6 h, 12 h, and 18 h, respectively...
October 31, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29095793/low-dose-sinapic-acid-abates-the-pyroptosis-of-macrophages-via-downregulation-of-lncrna-malat1-in-rats-with-diabetic-atherosclerosis
#9
Yong Han, Hong Qiu, Xing Pei, Yigang Fan, Hongyan Tian, Jie Geng
Pyroptosis is a type of programmed cell death, which has been associated with multiple inflammatory diseases including diabetic atherosclerosis (DA). The study aims to explore the role of sinapic acid (SA) in the pyroptosis of macrophages in diabetic atherosclerosis. Our results from the in vivo experiments showed that low-dose (≤ 50 mg/Kg) chronic SA adiministration suppressed serum endothelin 1 (ET-1) and interleukine-1β (IL-1β) contents, pyroptotic death of bone marrow derived macrophages (BMDMs), and the expression of pyroptotic proteins ASC, NRLP3 and Caspase-1...
October 27, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29046333/the-p53-inducible-long-noncoding-rna-trings-protects-cancer-cells-from-necrosis-under-glucose%C3%A2-starvation
#10
Muhammad Riaz Khan, Shaoxun Xiang, Zhiyin Song, Mian Wu
The tumor suppressor p53 is activated in response to cellular stress to prevent malignant transformation. However, several recent studies have shown that p53 can play protective roles in tumor cell survival under adversity. Whether p53-regulated long noncoding RNAs are involved in this process remains to be fully understood. Here, we show that under glucose starvation condition, p53 directly upregulates a novel lncRNA named TRINGS (Tp53-regulated inhibitor of necrosis under glucose starvation) in human tumor cells...
October 18, 2017: EMBO Journal
https://www.readbyqxmd.com/read/28985503/a-peptide-encoded-by-a-putative-lncrna-hoxb-as3-suppresses-colon-cancer-growth
#11
Jin-Zhou Huang, Min Chen, De Chen, Xing-Cheng Gao, Song Zhu, Hongyang Huang, Min Hu, Huifang Zhu, Guang-Rong Yan
A substantial fraction of eukaryotic transcripts are considered long non-coding RNAs (lncRNAs), which regulate various hallmarks of cancer. Here, we discovered that the lncRNA HOXB-AS3 encodes a conserved 53-aa peptide. The HOXB-AS3 peptide, not lncRNA, suppresses colon cancer (CRC) growth. Mechanistically, the HOXB-AS3 peptide competitively binds to the ariginine residues in RGG motif of hnRNP A1 and antagonizes the hnRNP A1-mediated regulation of pyruvate kinase M (PKM) splicing by blocking the binding of the ariginine residues in RGG motif of hnRNP A1 to the sequences flanking PKM exon 9, ensuring the formation of lower PKM2 and suppressing glucose metabolism reprogramming...
October 5, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28978906/energy-stress-induced-lncrna-filnc1-represses-c-myc-mediated-energy-metabolism-and-inhibits-renal-tumor-development
#12
Zhen-Dong Xiao, Leng Han, Hyemin Lee, Li Zhuang, Yilei Zhang, Joelle Baddour, Deepak Nagrath, Christopher G Wood, Jian Gu, Xifeng Wu, Han Liang, Boyi Gan
The roles of long non-coding RNAs in cancer metabolism remain largely unexplored. Here we identify FILNC1 (FoxO-induced long non-coding RNA 1) as an energy stress-induced long non-coding RNA by FoxO transcription factors. FILNC1 deficiency in renal cancer cells alleviates energy stress-induced apoptosis and markedly promotes renal tumor development. We show that FILNC1 deficiency leads to enhanced glucose uptake and lactate production through upregulation of c-Myc. Upon energy stress, FILNC1 interacts with AUF1, a c-Myc mRNA-binding protein, and sequesters AUF1 from binding c-Myc mRNA, leading to downregulation of c-Myc protein...
October 4, 2017: Nature Communications
https://www.readbyqxmd.com/read/28963395/lncrna-wires-up-hippo-and-hedgehog-signaling-to-reprogramme-glucose-metabolism
#13
Xin Zheng, Han Han, Guang-Ping Liu, Yan-Xiu Ma, Ruo-Lang Pan, Ling-Jie Sang, Rui-Hua Li, Luo-Jia Yang, Jeffrey R Marks, Wenqi Wang, Aifu Lin
The Hippo pathway plays essential roles in organ size control and cancer prevention via restricting its downstream effector, Yes-associated protein (YAP). Previous studies have revealed an oncogenic function of YAP in reprogramming glucose metabolism, while the underlying mechanism remains to be fully clarified. Accumulating evidence suggests long noncoding RNAs (lncRNAs) as attractive therapeutic targets, given their roles in modulating various cancer-related signaling pathways. In this study, we report that lncRNA breast cancer anti-estrogen resistance 4 (BCAR4) is required for YAP-dependent glycolysis...
November 15, 2017: EMBO Journal
https://www.readbyqxmd.com/read/28861164/danggui-buxue-tang-suppresses-high-glucose-induced-proliferation-and-extracellular-matrix-accumulation-of-mesangial-cells-via-inhibiting-lncrna-pvt1
#14
Rui Zhang, Jinbo Li, Tao Huang, Xiuge Wang
BACKGROUND: Danggui Buxue Tang (DBT), a traditional Chinese medicine decoction, has been proven to have satisfactory effects on treating diabetic nephropathy (DN). In this study, we explored the potential underlying mechanism of DBT in DN treatment. METHODS: The DBT-containning serum was prepared by intragastric administration with DBT for rats. The levels of fibronectin (FN), laminin (LN) and collagen IV (COL IV) and TGF-β1 protein secreted in cell culture medium were determined by ELISA assay...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28854438/down-regulation-of-lncrna-malat1-attenuates-neuronal-cell-death-through-suppressing-beclin1-dependent-autophagy-by-regulating-mir-30a-in-cerebral-ischemic-stroke
#15
Dong Guo, Ji Ma, Lei Yan, Tengfei Li, Zhiguo Li, Xinwei Han, Shaofeng Shui
BACKGROUND/AIMS: LncRNA metastasis associated lung adenocarcinoma transcript 1 (MALAT1) was reported to be highly expressed in an in vitro mimic of ischemic stroke conditions. However, the exact biological role of MALAT1 and its underlying mechanism in ischemic stroke remain to be elucidated. METHODS: The roles of MALAT1 and miR-30a on cell death and infarct volume and autophagy were evaluated in experimental ischemic stroke. The relationships between miR-30a and MALAT1, Beclin1 were confirmed by luciferase reporter assay...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28814771/rna-sequencing-of-db-db-mice-liver-identifies-lncrna-h19-as-a-key-regulator-of-gluconeogenesis-and-hepatic-glucose-output
#16
Neha Goyal, Ambily Sivadas, K V Shamsudheen, Rijith Jayarajan, Ankit Verma, Sridhar Sivasubbu, Vinod Scaria, Malabika Datta
Liver plays a key role in maintaining glucose homeostasis and impaired hepatic glucose metabolism is associated with type 2 diabetes. In the present study, we used RNA sequencing to profile the transcriptome of the livers of diabetic db/db mice as compared to the normal db/+ mice and identified 218 differentially expressed genes. Amongst these, there were 3 lncRNAs that were significantly downregulated and H19 was the most altered lncRNA in the livers of db/db mice. H19 expression significantly correlated with the expression of genes of the glycolysis and gluconeogenesis pathways, which suggest that altered hepatic H19 levels can directly or indirectly modulate their expression...
August 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28801479/the-role-of-interactions-of-long-non-coding-rnas-and-heterogeneous-nuclear-ribonucleoproteins-in-regulating-cellular-functions
#17
REVIEW
Xinghui Sun, Mohamed Sham Shihabudeen Haider Ali, Matthew Moran
Long non-coding RNAs (lncRNAs) are emerging as critical regulators of various biological processes and human diseases. The mechanisms of action involve their interactions with proteins, RNA and genomic DNA. Most lncRNAs display strong nuclear localization. Heterogeneous nuclear ribonucleoproteins (hnRNPs) are a large family of RNA-binding proteins that are important for multiple aspects of nucleic acid metabolism. hnRNPs are also predominantly expressed in the nucleus. This review discusses the interactions of lncRNAs and hnRNPs in regulating gene expression at transcriptional and post-transcriptional levels or by changing genomic structure, highlighting their involvements in glucose and lipid metabolism, immune response, DNA damage response, and other cellular functions...
August 11, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28780351/down-regulation-of-lncrna-kcnq1ot1-protects-against-myocardial-ischemia-reperfusion-injury-following-acute-myocardial-infarction
#18
Xin Li, Yingnan Dai, Shujun Yan, Yanli Shi, Baihe Han, Jingxiu Li, Li Cha, Jianjun Mu
This study aimed to investigate the protective effects of long non-coding RNA KCNQ1OT1 against myocardial ischemia/reperfusion (I/R) injury following acute myocardial infarction, as well as its regulatory mechanism. We used the cardiac muscle H9c2 cells under condition of oxygen glucose deprivation followed by reperfusion (OGD/R) to induce myocardial I/R injury. Then H9C2 cells were transfected with si-NC, si-KCNQ1OT1, pc-NC, pc-KCNQ1OT1, si-AdipoR1 and si-AdipoR2, respectively. The myocardial cell viability and apoptosis were respectively detected...
September 30, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28703801/lncrna-miat-functions-as-a-competing-endogenous-rna-to-upregulate-dapk2-by-sponging-mir-22-3p-in-diabetic-cardiomyopathy
#19
Xiang Zhou, Wei Zhang, Mengchao Jin, Jianchang Chen, Weiting Xu, Xiangqing Kong
We previously established a rat model of diabetic cardiomyopathy (DCM) and found that the expression of long non-coding RNA myocardial infarction-associated transcript (MIAT) was significantly upregulated. The present study was aimed to determine the pathologic role of MIAT in the development of DCM. MIAT knockdown was found to reduce cardiomyocyte apoptosis and improve left ventricular function in diabetic rats. High glucose could increase MIAT expression and induce apoptosis in cultured neonatal cardiomyocytes...
July 13, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28657668/long-noncoding-rna-bdnf-as-inversely-regulated-bdnf-and-modulated-high-glucose-induced-apoptosis-in-human-retinal-pigment-epithelial-cells
#20
Yanyan Li, Feng Xu, Hanyan Xiao, Feng Han
BACKGROUND: In this study, we characterized the functional role of long noncoding RNA (lncRNA), brain derived neurotrophic factor anti-sense (BDNF-AS) in regulating D-glucose-induced (DGI) apoptosis in human retinal pigment epithelial (RPE) cells. METHOD: Human RPE cell line, ARPE-19 cells were cultured in vitro and treated with various concentrations of D-glucose for 24 h. A TUNEL assay was applied with immunohistochemical and quantitative approaches to assess the apoptotic effect of D-glucose...
June 28, 2017: Journal of Cellular Biochemistry
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