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https://www.readbyqxmd.com/read/27903964/lncrna-h19-inhibits-autophagy-by-epigenetically-silencing-of-diras3-in-diabetic-cardiomyopathy
#1
Chuanjun Zhuo, Ronghuan Jiang, Xiaodong Lin, Mingjing Shao
We previously generated a rat model of diabetic cardiomyopathy and found that the expression of long non-coding RNA H19 was downregulated. The present study was aimed to explore the pathogenic role of H19 in the development of diabetic cardiomyopathy. Overexpression of H19 in diabetic rats attenuated cardiomyocyte autophagy and improved left ventricular function. High glucose was found to reduce H19 expression and increase autophagy in cultured neonatal cardiomyocytes. The results of RNA-binding protein immunoprecipitation showed that H19 could directly bind with EZH2 in cardiomyocytes...
November 26, 2016: Oncotarget
https://www.readbyqxmd.com/read/27876564/rncr3-a-regulator-of-diabetes-mellitus-related-retinal-microvascular-dysfunction
#2
Kun Shan, Chao-Peng Li, Chang Liu, Xin Liu, Biao Yan
Retinal microvascular abnormality is an important pathological feature of diabetic retinopathy. Herein, we report the role of lncRNA-RNCR3 in diabetes mellitus-induced retinal microvascular abnormalities. We show that RNCR3 is significantly up-regulated upon high glucose stress in vivo and in vitro. RNCR3 knockdown alleviates retinal vascular dysfunction in vivo, as shown by decreased retinal acellular capillaries, decreased vascular leakage, and reduced inflammatory response. RNCR3 knockdown decreases retinal endothelial cell proliferation, and reduces cell migration and tube formation in vitro...
November 19, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27864543/long-non-coding-rnas-a-novel-paradigm-for-toxicology
#3
REVIEW
Joseph L Dempsey, Julia Yue Cui
Long non-coding RNAs (lncRNAs) are over 200 nucleotides in length and are transcribed from the mammalian genome in a tissue-specific and developmentally regulated pattern. There is growing recognition that lncRNAs are novel biomarkers and/or key regulators of toxicological responses in humans and animal models. Lacking protein-coding capacity, the numerous types of lncRNAs possess a myriad of transcriptional regulatory functions that include cis and trans gene expression, transcription factor activity, chromatin remodeling, imprinting, and enhancer up-regulation...
November 17, 2016: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/27844279/lncrna-n1lr-enhances-neuroprotection-against-ischemic-stroke-probably-by-inhibiting-p53-phosphorylation
#4
Zhuomin Wu, Ping Wu, Xialin Zuo, Na Yu, Yixin Qin, Qian Xu, Shuai He, Bohong Cen, Wenjie Liao, Aimin Ji
In recent years, long noncoding RNAs (lncRNAs) have been shown to have critical roles in a broad range of cell biological processes. However, the activities of lncRNAs during ischemic stroke remain largely unknown. In this study, we carried out a genome-wide lncRNA microarray analysis in rat brains with ischemia/reperfusion (I/R) injury. The results revealed the differential expression of a subset of lncRNAs. Through the construction of lncRNA-mRNA co-expression networks, we identified lncRNA-N1LR as a novel I/R-induced lncRNA...
November 14, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27813675/the-steroidogenic-acute-regulatory-protein-star-is-regulated-by-the-h19-let-7-axis
#5
Yi Men, Yanhong Fan, Yuanyuan Shen, Lingeng Lu, Amanda N Kallen
The steroidogenic acute regulatory protein (StAR) governs the rate-limiting step in steroidogenesis, and its expression varies depending on the needs of the specific tissue. Tight control of steroid production is essential for multiple processes involved in reproduction, including follicular development, ovulation, and endometrial synchronization. Recently, there has been a growing interest in the role of noncoding RNAs in the regulation of reproduction. Here we demonstrate that StAR is a novel target of the microRNA let-7, which itself is regulated by the long noncoding RNA (lncRNA) H19...
November 4, 2016: Endocrinology
https://www.readbyqxmd.com/read/27809873/lncrnas-h19-and-hulc-activated-by-oxidative-stress-promote-cell-migration-and-invasion-in-cholangiocarcinoma-through-a-cerna-manner
#6
Wen-Tao Wang, Hua Ye, Pan-Pan Wei, Bo-Wei Han, Bo He, Zhen- Hua Chen, Yue-Qin Chen
BACKGROUND: Long non-coding RNAs (lncRNAs) are known to play important roles in different cell contexts, including cancers. However, little is known about lncRNAs in cholangiocarcinoma (CCA), a cholangiocyte malignancy with poor prognosis, associated with chronic inflammation and damage to the biliary epithelium. The aim of the study is to identify if any lncRNA might associate with inflammation or oxidative stress in CCA and regulate the disease progression. METHODS: In this study, RNA-seqs datasets were used to identify aberrantly expressed lncRNAs...
November 3, 2016: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/27796346/lncrna-h19-mir-675-axis-regulates-cardiomyocyte-apoptosis-by-targeting-vdac1-in-diabetic-cardiomyopathy
#7
Xiangquan Li, Hao Wang, Biao Yao, Weiting Xu, Jianchang Chen, Xiang Zhou
We previously established a rat model of diabetic cardiomyopathy (DCM) and found that the expression of lncRNA H19 was significantly downregulated. The present study was designed to investigate the pathogenic role of H19 in the development of DCM. Overexpression of H19 in diabetic rats attenuated oxidative stress, inflammation and apoptosis, and consequently improved left ventricular function. High glucose was associated with reduced H19 expression and increased cardiomyocyte apoptosis. To explore the molecular mechanisms involved, we performed in vitro experiments using cultured neonatal rat cardiomyocytes...
October 31, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27792451/lncrna-nbr2-modulates-cancer-cell-sensitivity-to-phenformin-through-glut1
#8
Xiaowen Liu, Boyi Gan
Biguanides, including metformin (widely used in diabetes treatment) and phenformin, are AMP-activated protein kinase (AMPK) activators and potential drugs for cancer treatment. A more in-depth understanding of how cancer cells adapt to biguanide treatment may provide important therapeutic implications to achieve more effective and rational cancer therapies. NBR2 is a glucose starvation-induced long non-coding RNA (lncRNA) that interacts with AMPK and regulates AMPK activity upon glucose starvation. Here we show that phenformin treatment induces NBR2 expression, and NBR2 deficiency sensitizes cancer cells to phenformin-induced cell death...
October 28, 2016: Cell Cycle
https://www.readbyqxmd.com/read/27759039/lncrna-sra-promotes-hepatic-steatosis-through-repressing-the-expression-of-adipose-triglyceride-lipase-atgl
#9
Gang Chen, Dongsheng Yu, Xue Nian, Junyi Liu, Ronald J Koenig, Bin Xu, Liang Sheng
Nonalcoholic fatty liver disease (NAFLD), the most common form of chronic liver disease, manifests as an over-accumulation of hepatic fat. We have recently shown that mice with genetic knockout of a long non-coding RNA (lncRNA) steroid receptor RNA activator (SRA) (SRAKO) are resistant to high fat diet-induced obesity with a phenotype that includes improved glucose tolerance and attenuated hepatic steatosis. The underlying mechanism was investigated in the present study. We found that hepatic levels of SRA and adipose triglyceride lipase (ATGL), a major hepatic triacylglycerol (TAG) hydrolase, were inversely regulated by fasting in mice, and the expression of liver ATGL was induced by SRAKO under normal and high fat diet (HFD) feeding...
October 19, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27723196/rna-decay-systems-enhance-reciprocal-switching-of-sense-and-antisense-transcripts-in-response-to-glucose-starvation
#10
Atsuko Miki, Josephine Galipon, Satoshi Sawai, Toshifumi Inada, Kunihiro Ohta
Antisense RNA has emerged as a crucial regulator of opposite-strand protein-coding genes in the long noncoding RNA (lncRNA) category, but little is known about their dynamics and decay process in the context of a stress response. Antisense transcripts from the fission yeast fbp1 locus (fbp1-as) are expressed in glucose-rich conditions and anticorrelated with transcription of metabolic stress-induced lncRNA (mlonRNA) and mRNA on the sense strand during glucose starvation. Here, we investigate the localization and decay of antisense RNAs at fbp1 and other loci, and propose a model to explain the rapid switch between antisense and sense mlonRNA/mRNA transcription triggered by glucose starvation...
October 10, 2016: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
https://www.readbyqxmd.com/read/27693963/high-glucose-prevents-osteogenic-differentiation-of-mesenchymal-stem-cells-via-lncrna-ak028326-cxcl13-pathway
#11
Boran Cao, Ning Liu, Wenbo Wang
BACKGROUND: High glucose (HG) often induces unfavorable effects on proliferation and differentiation of mesenchymal stem cells (MSCs). This study aimed to explore potential molecular pathways underlying HG functional mechanism during osteogenic differentiation of MSCs, involving lncRNA AK028326 and CXCL13. METHODS: Murine bone marrow-derived MSCs were cultured in osteogenic-inducing medium supplemented with high glucose level at 25mM or 5.5mM as normal control. Expression levels of lncRNA AK028326 and CXCL13 were measured by using real-time PCR...
September 28, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27686049/an-endoplasmic-reticulum-stress-regulated-lncrna-hosting-a-microrna-megacluster-induces-early-features-of-diabetic-nephropathy
#12
Mitsuo Kato, Mei Wang, Zhuo Chen, Kirti Bhatt, Hyung Jung Oh, Linda Lanting, Supriya Deshpande, Ye Jia, Jennifer Y C Lai, Christopher L O'Connor, YiFan Wu, Jeffrey B Hodgin, Robert G Nelson, Markus Bitzer, Rama Natarajan
It is important to find better treatments for diabetic nephropathy (DN), a debilitating renal complication. Targeting early features of DN, including renal extracellular matrix accumulation (ECM) and glomerular hypertrophy, can prevent disease progression. Here we show that a megacluster of nearly 40 microRNAs and their host long non-coding RNA transcript (lnc-MGC) are coordinately increased in the glomeruli of mouse models of DN, and mesangial cells treated with transforming growth factor-β1 (TGF- β1) or high glucose...
2016: Nature Communications
https://www.readbyqxmd.com/read/27642276/the-mechanism-of-long-non-coding-rna-meg3-for-neurons-apoptosis-caused-by-hypoxia-mediated-by-mir-181b-12-15-lox-signaling-pathway
#13
Xiaomin Liu, Lijing Hou, Weiwei Huang, Yuan Gao, Xin Lv, Jiyou Tang
OBJECTIVE: lncRNAs are recently thought to play a significant role in cellular homeostasis during pathological process of diseases by competing inhibiting miRNA function. The aim of present study was to assess the function of long non-coding RNA (lncRNA) MEG3 and its functional interaction with microRNA-181b in cerebral ischemic infarct of mice and hypoxia-induced neurons apoptosis. METHODS: To address this question, we performed the experiments with in vivo middle cerebral artery occlusion (MCAO) mice model and in vitro oxygen-glucose deprivation (OGD)-cultured neuronal HT22 cell line...
2016: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/27609221/epigenomic-and-metabolic-responses-of-hypothalamic-pomc-neurons-to-gestational-nicotine-exposure-in-adult-offspring
#14
Jose P Silva, Guerline Lambert, Derek van Booven, Claes Wahlestedt
BACKGROUND: Epidemiological and animal studies have reported that prenatal nicotine exposure (PNE) leads to obesity and type-2 diabetes in offspring. Central leptin-melanocortin signaling via hypothalamic arcuate proopiomelanocortin (POMC) neurons is crucial for the regulation of energy and glucose balance. Furthermore, hypothalamic POMC neurons were recently found to mediate the anorectic effects of nicotine through activation of acetylcholine receptors. Here, we hypothesized that PNE impairs leptin-melanocortinergic regulation of energy balance in first-generation offspring by altering expression of long non-coding RNAs (lncRNAs) putatively regulating development and/or function of hypothalamic POMC neurons...
2016: Genome Medicine
https://www.readbyqxmd.com/read/27557514/lncrna-anril-is-up-regulated-in-nasopharyngeal-carcinoma-and-promotes-the-cancer-progression-via-increasing-proliferation-reprograming-cell-glucose-metabolism-and-inducing-side-population-stem-like-cancer-cells
#15
Zhen Wei Zou, Charlie Ma, Lorraine Medoro, Lili Chen, Bin Wang, Roohi Gupta, Ting Liu, Xian Zi Yang, Tian Tian Chen, Ruo Zhen Wang, Wen Jie Zhang, Pin Dong Li
Long noncoding RNAs play a vital role in diverse biological processes such as embryonic development, cell growth, and tumorigenesis. In this study, we report that LncRNA ANRIL, which encodes a 3834-nt RNA that contains 19 exons at the antisense orientation of the INK4B-ARF-INK4A gene cluster, generally up-regulated in nasopharyngeal carcinoma [1]. In a cohort of 88 NPC patients, ANRIL was highly expressed in advanced-stage cancer. Multivariate analyses revealed that ANRIL expression could serve as an independent predictor of overall survival (P = 0...
August 20, 2016: Oncotarget
https://www.readbyqxmd.com/read/27519467/lncrna-nonratt021972-sirna-rescued-decreased-heart-rate-variability-in-diabetic-rats-in-superior-cervical-ganglia
#16
Hong Xu, Changle Liu, Shenqiang Rao, Luling He, Tengling Zhang, Shanshan Sun, Bing Wu, Lifang Zou, Shouyu Wang, Yun Xue, Tianyu Jia, Shanhong Zhao, Guilin Li, Shuangmei Liu, Guodong Li, Shangdong Liang
Diabetic cardiac autonomic neuropathy (DCAN) is a serious and common complication in diabetes mellitus (DM). Long noncoding RNAs (lncRNAs), an important class of regulatory molecules in diverse biological processes, have attracted considerable interest in DCAN. Our previous study has indicated a lncRNA, NONRATT021972 (NONCODE ID), was enhanced in sympathetic neuronal-like PC12 cells in the setting of high glucose (HG) and high FFAs (HF); its silence was found to significantly alleviate HGHF-induced tumor necrosis factor-α (TNF-α) release in PC12 cells...
August 5, 2016: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/27434139/a-global-profile-of-glucose-sensitive-endothelial-expressed-long-non-coding-rnas
#17
Krishna K Singh, Laura-Eve Mantella, Yi Pan, Adrian Quan, Sandra Sabongui, Paul Sandhu, Hwee Teoh, Mohammed Al-Omran, Subodh Verma
Hyperglycemia-related endothelial dysfunction is believed to be the crux of diabetes-associated micro- and macro-vascular complications. We conducted a systematic transcriptional survey to screen for human endothelial long non-coding RNAs (lncRNAs) regulated by elevated glucose levels. lncRNAs and protein-coding transcripts from human umbilical vein endothelial cells (HUVECs) cultured under high (25 mmol/L) or normal (5 mmol/L) glucose conditions for 24 h were profiled with the Arraystar Human LncRNA Expression Microarray V3...
September 2016: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/27432655/involvement-of-endoplasmic-reticulum-stress-and-p53-in-lncrna-meg3-induced-human-hepatoma-hepg2-cell-apoptosis
#18
Rui-Pei Chen, Zhen-Lun Huang, Li-Xuan Liu, Meng-Qi Xiang, Guo-Ping Li, Jia-Lin Feng, Bin Liu, Ling-Fei Wu
Long non-coding RNAs (lncRNAs) play important roles in diverse biological processes. Although downregulation of lncRNA maternally expressed gene 3 (MEG3) has been identified in several types of cancers, little is known concerning its biological role and regulatory mechanism in hepatoma. Our previous studies demonstrated that MEG3 induces apoptosis in a p53-dependent manner. The aim of the present study was to determine whether endoplasmic reticulum (ER) stress is involved in MEG3‑induced apoptosis. Recombinant lentiviral vectors containing MEG3 (Lv‑MEG3) were constructed and transfected into HepG2 cells...
September 2016: Oncology Reports
https://www.readbyqxmd.com/read/27376736/noncoding-rnas-in-regulation-of-cancer-metabolic-reprogramming
#19
Dongdong Yang, Linchong Sun, Zhaoyong Li, Ping Gao
Since the description of the Warburg effect 90 years ago, metabolic reprogramming has been gradually recognized as a major hallmark of cancer cells. Mounting evidence now indicates that cancer is a kind of metabolic disease, quite distinct from conventional perception. While metabolic alterations in cancer cells have been extensively observed in glucose, lipid, and amino acid metabolisms, its underlying regulatory mechanisms are still poorly understood. Noncoding RNA, also known as the "dark matter in life," functions through various mechanisms at RNA level regulating different biological pathways...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27335687/long-non-coding-rna-mediated-regulation-of-glucose-homeostasis-and-diabetes
#20
REVIEW
Xinghui Sun, Danny Wong
Long non-coding RNAs (lncRNAs) represent an important class of non-coding RNAs that plays key roles in regulating the expression of genes in health and disease. Accumulating genetic, experimental, and epidemiological studies highlight a growing list of lncRNAs that control glucose homeostasis and diabetic pathologies and complications. Through interactions with chromatin, RNA, and protein, lncRNAs modulate chromatin modification, mRNA stability, microRNA activity, and the function of proteins such as transcription factors...
2016: American Journal of Cardiovascular Disease
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