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https://www.readbyqxmd.com/read/28434158/physical-performance-in-newly-diagnosed-hypothyroidism-a-pilot-study
#1
D Gallo, E Piantanida, G Veronesi, A Lai, L Sassi, V Lombardi, E Masiello, P Premoli, E Bianconi, C Cusini, S Rosetti, M L Tanda, A Toniolo, M Ferrario, L Bartalena
OBJECTIVE: Hypothyroidism is complicated by neuromuscular symptoms (myalgias, slowness of movements, and tiredness) and signs (easy fatigability and cramps), which may have a negative impact on general well-being and quality of life. In a pilot, prospective, controlled study, we investigated the features of muscle dysfunction in hypothyroidism by disease questionnaire, biochemical measures, and physical performance tests. MATERIALS AND METHODS: Fifty-seven consecutive patients with newly diagnosed hypothyroidism were enrolled, 27 subclinical (S-Hypo) and 30 overt (O-Hypo)...
April 22, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28434004/what-do-medical-students-know-about-deep-brain-stimulation
#2
Andreas Wloch, Assel Saryyeva, Hans E Heissler, Christoph Schrader, H Holger Capelle, Joachim K Krauss
BACKGROUND: Deep brain stimulation (DBS) is an established therapy for movement disorders. It is currently under investigation in neuropsychiatric disorders. Neurophobia is a common phenomenon that might have a negative impact in medical education. Little is known about medical students' knowledge about DBS when they enter university and what they learn about it during their medical formation. METHODS: A 10-item questionnaire was designed. Questions addressed indications for DBS, costs of DBS, complications, the percentage of Parkinson disease (PD) patients who might profit from DBS, etc...
April 22, 2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/28433831/ultrasonography-of-the-transverse-movement-and-deformation-of-the-median-nerve-and-its-relationships-with-electrophysiological-severity-in-the-early-stages-of-carpal-tunnel-syndrome
#3
Donghwi Park
BACKGROUND: To date, there have been conflicting suggestions regarding theinitial pathogenesis of CTS.It has been characterized as either inflammation of the median nerve caused by compression ornon-inflammatory fibrosis of the subsynovial connective tissue (SSCT). OBJECTIVE: To investigate the initialpathogenesis of CTS, we compared the deformation and displacement of the median nerve in accordance with the electrophysiological severity between patients with CTS (via Bland`s scale) and healthy controls...
April 19, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28433337/increased-resource-utilization-and-overall-morbidity-are-associated-with-general-versus-regional-anesthesia-for-carotid-endarterectomy-in-data-collected-by-the-michigan-surgical-quality-collaborative
#4
Ahmad S Hussain, Andrew Mullard, William F Oppat, Kevin D Nolan
OBJECTIVE: Advocates for performing carotid endarterectomy (CEA) under regional anesthesia (RA) cite reduction in hemodynamic instability and the ability for neurologic monitoring, but many still prefer general anesthesia (GA) as benefits of RA have not been clearly demonstrated, reliable RA may not be available in all centers, and a certain amount of movement by the patient during the procedure may not be uniformly tolerated. We evaluated the association of anesthesia type and perioperative morbidity and mortality as well as resource utilization in patients undergoing CEA using the Michigan Surgical Quality Collaborative (MSQC) database...
April 19, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28430887/measurement-of-forces-and-moments-around-the-maxillary-arch-for-treatment-of-a-simulated-lingual-incisor-and-high-canine-malocclusion-using-straight-and-mushroom-archwires-in-fixed-lingual-appliances
#5
Brandon Owen, Geoffry Gullion, Giseon Heo, Jason P Carey, Paul W Major, Dan L Romanyk
Introduction: An Orthodontic SIMulator (OSIM) was used to investigate the propagation of forces and moments around a simulated archform for a gingival displaced canine and lingual displaced lateral incisor using fixed lingual orthodontic appliances. Methods: In-Ovation L self-ligating lingual brackets were bonded to anatomically shaped teeth on the OSIM, and the teeth were positioned such that a G4 NiTi 0.016" large maxillary mushroom archwire could be ligated in passive position...
April 20, 2017: European Journal of Orthodontics
https://www.readbyqxmd.com/read/28430193/self-propelled-supramolecular-nanomotors-with-temperature-responsive-speed-regulation
#6
Yingfeng Tu, Fei Peng, Xiaofeng Sui, Yongjun Men, Paul B White, Jan C M van Hest, Daniela A Wilson
Self-propelled catalytic micro- and nanomotors have been the subject of intense study over the past few years, but it remains a continuing challenge to build in an effective speed-regulation mechanism. Movement of these motors is generally fully dependent on the concentration of accessible fuel, with propulsive movement only ceasing when the fuel consumption is complete. Here we report a demonstration of control over the movement of self-assembled stomatocyte nanomotors via a molecularly built, stimulus-responsive regulatory mechanism...
May 2017: Nature Chemistry
https://www.readbyqxmd.com/read/28429416/modulation-of-heterotypic-and-homotypic-cell-cell-interactions-via-zwitterionic-lipid-masks
#7
Matthew Park, Wongu Youn, Doyeon Kim, Eun Hyea Ko, Beom Jin Kim, Sung Min Kang, Kyungtae Kang, Insung S Choi
Since the pioneering work by Whitesides, innumerable platforms that aim to spatio-selectively seed cells and control the degree of cell-cell interactions in vitro have been developed. These methods, however, have generally been technically and methodologically complex, or demanded stringent materials and conditions. In this work, we introduce zwitterionic lipids as patternable, cell-repellant masks for selectively seeding cells. The lipid masks are easily removed with a routine washing step under physiological conditions (37 °C, pH 7...
April 21, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28427008/lateral-hypothalamic-circuits-for-sleep-wake-control
#8
REVIEW
Takayuki Yamashita, Akihiro Yamanaka
The lateral hypothalamic area (LHA) of the diencephalon is crucially involved in controlling instinctive behavior such as sleep-wake cycle and feeding behavior. LHA is a heterogeneous structure that contains spatially intermingled, genetically distinct cell populations. Among LHA neurons, orexin/hypocretin (OX) neuron is the key cell type that promotes waking, and specific loss of OX neurons results in narcolepsy. Melanin-concentrating hormone (MCH) containing neurons are known to be active during rapid eye movement (REM) sleep and stimulation of these neurons promotes REM sleep...
April 17, 2017: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/28424649/connections-of-grasping-and-horizontal-hand-movements-with-articulation-in-czech-speakers
#9
Mikko Tiainen, Jiří Lukavský, Kaisa Tiippana, Martti Vainio, Juraj Šimko, Fatima Felisberti, Lari Vainio
We have recently shown in Finnish speakers that articulation of certain vowels and consonants has a systematic influence on simultaneous grasp actions as well as on forward and backward hand movements. Here we studied whether these effects generalize to another language, namely Czech. We reasoned that if the results generalized to another language environment, it would suggest that the effects arise through other processes than language-dependent semantic associations. Rather, the effects would be likely to arise through language-independent interactions between processes that plan articulatory gestures and hand movements...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28422954/identification-of-the-contribution-of-contact-and-aerial-biomechanical-parameters-in-acrobatic-performance
#10
Diane Haering, Aurore Huchez, Franck Barbier, Patrice Holvoët, Mickaël Begon
INTRODUCTION: Teaching acrobatic skills with a minimal amount of repetition is a major challenge for coaches. Biomechanical, statistical or computer simulation tools can help them identify the most determinant factors of performance. Release parameters, change in moment of inertia and segmental momentum transfers were identified in the prediction of acrobatics success. The purpose of the present study was to evaluate the relative contribution of these parameters in performance throughout expertise or optimisation based improvements...
2017: PloS One
https://www.readbyqxmd.com/read/28420999/functional-high-intensity-circuit-training-improves-body-composition-peak-oxygen-uptake-strength-and-alters-certain-dimensions-of-quality-of-life-in-overweight-women
#11
Billy Sperlich, Birgit Wallmann-Sperlich, Christoph Zinner, Valerie Von Stauffenberg, Helena Losert, Hans-Christer Holmberg
The effects of circuit-like functional high-intensity training (CircuitHIIT) alone or in combination with high-volume low-intensity exercise (Circuitcombined) on selected cardio-respiratory and metabolic parameters, body composition, functional strength and the quality of life of overweight women were compared. In this single-center, two-armed randomized, controlled study, overweight women performed 9-weeks (3 sessions·wk(-1)) of either CircuitHIIT (n = 11), or Circuitcombined (n = 8). Peak oxygen uptake and perception of physical pain were increased to a greater extent (p < 0...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28420954/multiple-kernel-based-region-importance-learning-for-neural-classification-of-gait-states-from-eeg-signals
#12
Yuhang Zhang, Saurabh Prasad, Atilla Kilicarslan, Jose L Contreras-Vidal
With the development of Brain Machine Interface (BMI) systems, people with motor disabilities are able to control external devices to help them restore movement abilities. Longitudinal validation of these systems is critical not only to assess long-term performance reliability but also to investigate adaptations in electrocortical patterns due to learning to use the BMI system. In this paper, we decode the patterns of user's intended gait states (e.g., stop, walk, turn left, and turn right) from scalp electroencephalography (EEG) signals and simultaneously learn the relative importance of different brain areas by using the multiple kernel learning (MKL) algorithm...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28419980/evaluation-of-glut1-variation-in-non-acquired-focal-epilepsy
#13
Alexander Peeraer, John A Damiano, Susannah T Bellows, Ingrid E Scheffer, Samuel F Berkovic, Saul A Mullen, Michael S Hildebrand
Brain glucose transport is dependent on glucose transporter 1 (GLUT1), encoded by the solute carrier family 2 member 1 (SLC2A1) gene. Mutations in SLC2A1 cause GLUT1 deficiency which is characterized by a broad spectrum of neurological phenotypes including generalized epilepsy, motor disorders, developmental delay and microcephaly. Recent case reports suggest SLC2A1 mutations can contribute to non-acquired focal epilepsy (NAFE) but interrogation of a large patient cohort has not been reported. We studied 200 patients with NAFE (126 with temporal lobe epilepsy) comprising 104 females and 96 males with a mean age of onset of 18 years...
April 10, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28419879/challenging-the-myth-of-right-non-dominant-hemisphere-lessons-from-cortico-subcortical-stimulation-mapping-in-awake-surgery-and-surgical-implications
#14
REVIEW
Tatiana Vilasboas, Guillaume Herbet, Hugues Duffau
For a long time, the right hemisphere (RH) was considered as "non-dominant", especially in right-handers. In neurosurgical practice, this dogma resulted in the selection of awake procedure with language mapping only for lesions of the left "dominant" hemisphere. Conversely, surgery under general anesthesia (possibly with motor mapping) was usually proposed for right lesions. However, when objective neuropsychological assessments were performed, they frequently revealed cognitive and behavioral deficits following brain surgery, even in the RH...
April 15, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28418326/artifact-in-pediatric-oculomotor-findings-during-videonystagmography-a-retrospective-analysis
#15
Steven M Doettl, Patrick N Plyler, Devin L McCaslin
BACKGROUND: Accurate measurement of oculomotor function using videonystagmography (VNG) is imperative for diagnosis and management of patients with reported dizziness. The oculomotor evaluation during VNG utilizes video-oculography providing valuable information regarding the central structures and pathways that control eye movements. Artifact may have an effect on the overall validity and reliability of VNG oculomotor tracings and can result from patient and/or recording errors. It is postulated that artifact could occur more frequently in the pediatric population due to both patient and equipment factors...
April 2017: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/28416352/setting-them-up-for-lifetime-activity-play-competence-perceptions-and-physical-activity-in-young-children
#16
Lisa M Barnett, Nicola D Ridgers, Kylie Hesketh, Jo Salmon
OBJECTIVES: Possessing positive physical perceived competence is important for physical activity in older children. Young children are primarily physically active through play-based behaviour rather than through organised sports and activities, so understanding how play perceptions might influence physical activity behaviour is important. The study purpose was to assess if perceived active play competence is associated with young children's physical activity. DESIGN: Cross sectional study...
March 21, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28414674/a-clot-possibly-due-to-loss-of-tnf-%C3%AE-supression
#17
J Broussard, M Berlinger, D Lauret
INTRODUCTION: Inflammation and venous thrombosis enjoy a close Relationship. We present a patient who had multiple DVTs following the discontinuation of anti- TNF-α therapy. CASE: A 34 year old African American female with a history of multiple DVT's, miscarriages, and reported Crohn's disease presented with shortness of breath. In the Emergency Department, CTA showed bilateral pulmonary emboli. The patient had been off adalimumab for one year and reported abdominal pain with 6-7 non-bloody bowel movements daily...
March 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28414047/a-novel-automated-rodent-tracker-art-demonstrated-in-a-mouse-model-of-amyotrophic-lateral-sclerosis
#18
Brett M Hewitt, Moi Hoon Yap, Emma F Hodson-Tole, Aneurin J Kennerley, Paul S Sharp, Robyn A Grant
BACKGROUND: Generating quantitative metrics of rodent locomotion and general behaviours from video footage is important in behavioural neuroscience studies. However, there is not yet a free software system that can process large amounts of video data with minimal user interventions. NEW METHOD: Here we propose a new, automated rodent tracker (ART) that uses a simple rule-based system to quickly and robustly track rodent nose and body points, with minimal user input...
April 13, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28413688/presentation-and-care-of-a-family-with-huntington-disease-in-a-resource-limited-community
#19
Jarmal Charles, Lindyann Lessey, Jennifer Rooney, Ingmar Prokop, Katherine Yearwood, Hazel Da Breo, Patrick Rooney, Ruth H Walker, Andrew K Sobering
BACKGROUND: In high-income countries patients with Huntington disease (HD) typically present to healthcare providers after developing involuntary movements, or for pre-symptomatic genetic testing if at familial risk. A positive family history is a major guide when considering the decision to perform genetic testing for HD, both in affected and unaffected patients. Management of HD is focused upon control of symptoms, whether motor, cognitive, or psychiatric. There is no clear evidence to date of any disease-modifying agents...
2017: Journal of Clinical Movement Disorders
https://www.readbyqxmd.com/read/28411234/phenotype-of-gaba-transaminase-deficiency
#20
Mary Kay Koenig, Ryan Hodgeman, James J Riviello, Wendy Chung, Jennifer Bain, Claudia A Chiriboga, Kazushi Ichikawa, Hitoshi Osaka, Megumi Tsuji, K Michael Gibson, Penelope E Bonnen, Phillip L Pearl
OBJECTIVE: We report a case series of 10 patients with γ-aminobutyric acid (GABA)-transaminase deficiency including a novel therapeutic trial and an expanded phenotype. METHODS: Case ascertainment, literature review, comprehensive evaluations, and long-term treatment with flumazenil. RESULTS: All patients presented with neonatal or early infantile-onset encephalopathy; other features were hypotonia, hypersomnolence, epilepsy, choreoathetosis, and accelerated linear growth...
April 14, 2017: Neurology
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