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https://www.readbyqxmd.com/read/28109988/epilepsy-and-restless-legs-syndrome
#1
James D Geyer, Emery E Geyer, Zachary Fetterman, Paul R Carney
OBJECTIVE: Restless legs syndrome (RLS) is a common neurological movement disorder occurring in approximately 10% of the general population. The prevalence of moderately severe RLS is 2.7% overall (3.7% for women and 1.7% for men). Epilepsy is also a common neurological disorder with significant associated morbidity and impact on quality of life. We evaluated the severity and frequency of primary RLS in patients with localization-related temporal lobe epilepsy (TLE) and investigated the role of prodromal RLS symptoms as a warning sign and lateralizing indicator...
January 18, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28109267/the-use-of-physical-restraints-in-long-term-care-in-spain-a-multi-center-cross-sectional-study
#2
Gabriel J Estévez-Guerra, Emilio Fariña-López, Eduardo Núñez-González, Manuel Gandoy-Crego, Fernando Calvo-Francés, Elizabeth A Capezuti
BACKGROUND: Physical restraint is a procedure used frequently in long-term care. It is a controversial practice because its use is associated with numerous complications and also affects freedom and individual autonomy. The objective of this study was to examine the use of physical restraint of long-term care residents with the ability to move voluntarily. METHODS: We conducted a cross-sectional observational and correlational multi-center study. Nine centers agreed to participate...
January 21, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28107109/sex-with-neighbors-canada-and-canadians-in-the-u-s-homophile-press
#3
Marc Stein
This article examines U.S. homophile magazine contributions from and representations of Canada from 1953 to 1964. Drawing on 240 articles, letters, and other items that were published in ONE, Mattachine Review, and The Ladder, the essay first reviews Canadian-authored materials and then shows that U.S. gay and lesbian movement periodicals depicted Canada as more sexually conservative than the United States in three ways and more sexually liberal in one way. The magazines presented Canada as more sexually conservative in its failure to develop an organized gay and lesbian movement, its policies and practices of sexual censorship, and its opposition to progressive homosexual law reform...
January 20, 2017: Journal of Homosexuality
https://www.readbyqxmd.com/read/28106025/aneurysm-of-the-muscular-septum-associated-with-wolf-parkinson-white-syndrome-presenting-as-dilated-cardiomyopathy-a-report-of-two-cases
#4
Vehbi Doğan, İlker Ertuğrul, Şeyma Kayalı, Utku Arman Örün, Selmin Karademir
Muscular septal aneurysms are extremely rare without a ventricular septal defect and are diagnosed accidentally in most cases. Reported cases generally have rhythm disturbance or electrocardiographic findings of Wolf-Parkinson-White (WPW) syndrome. Presently described are 2 cases of ventricular septal aneurysm associated with WPW syndrome, which presented as dilated cardiomyopathy. Pre-excitation disappeared gradually in first patient. There was also concurrent decrease in degree of bulging of the interventricular septum and improvement of left ventricular systolic function...
January 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28103638/music-interventions-for-acquired-brain-injury
#5
REVIEW
Wendy L Magee, Imogen Clark, Jeanette Tamplin, Joke Bradt
BACKGROUND: Acquired brain injury (ABI) can result in impairments in motor function, language, cognition, and sensory processing, and in emotional disturbances, which can severely reduce a survivor's quality of life. Music interventions have been used in rehabilitation to stimulate brain functions involved in movement, cognition, speech, emotions, and sensory perceptions. An update of the systematic review published in 2010 was needed to gauge the efficacy of music interventions in rehabilitation for people with ABI...
January 20, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28100251/consensus-guideline-for-the-diagnosis-and-treatment-of-aromatic-l-amino-acid-decarboxylase-aadc-deficiency
#6
REVIEW
Tessa Wassenberg, Marta Molero-Luis, Kathrin Jeltsch, Georg F Hoffmann, Birgit Assmann, Nenad Blau, Angeles Garcia-Cazorla, Rafael Artuch, Roser Pons, Toni S Pearson, Vincenco Leuzzi, Mario Mastrangelo, Phillip L Pearl, Wang Tso Lee, Manju A Kurian, Simon Heales, Lisa Flint, Marcel Verbeek, Michèl Willemsen, Thomas Opladen
Aromatic L-amino acid decarboxylase deficiency (AADCD) is a rare, autosomal recessive neurometabolic disorder that leads to a severe combined deficiency of serotonin, dopamine, norepinephrine and epinephrine. Onset is early in life, and key clinical symptoms are hypotonia, movement disorders (oculogyric crisis, dystonia, and hypokinesia), developmental delay, and autonomic symptoms.In this consensus guideline, representatives of the International Working Group on Neurotransmitter Related Disorders (iNTD) and patient representatives evaluated all available evidence for diagnosis and treatment of AADCD and made recommendations using SIGN and GRADE methodology...
January 18, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28096469/super-resolution-visualization-of-caveolae-deformation-in-response-to-osmotic-stress
#7
Lu Yang, Suzanne Scarlata
Caveolae are protein dense plasma membrane domains structurally composed of caveolin -1 or -3 along with other proteins. Our previous studies have shown that caveolae enhance calcium signals generated through the Gαq/phospholipase Cβ signaling pathway, and that subjecting cells to hypo-osmotic stress reverses this enhancement. In this study, we have used super-resolution fluorescence microscopy supplemented by fluorescence correlation studies to determine the structural factors that underlie this behavior...
January 17, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28095143/-the-madness-of-the-carnival-representations-of-latin-america-and-the-caribbean-in-the-u-s-homophile-press
#8
Shlomo Gleibman
This essay examines representations of Latin America and the Caribbean in U.S. homophile periodicals from 1953 to 1964. The 120 items in ONE, Mattachine Review, and The Ladder that referenced this region depicted Latin America and the Caribbean as different from the United States in a number of ways, in particular as more sexually repressive or more sexually liberal. These representations typically conformed to the general homophile movement tendency to challenge U.S. anti-homosexual campaigns during the "Lavender Scare," while arguing for acceptance based on rights claims...
January 17, 2017: Journal of Homosexuality
https://www.readbyqxmd.com/read/28095009/cross-lingual-neighborhood-effects-in-generalized-lexical-decision-and-natural-reading
#9
Nicolas Dirix, Uschi Cop, Denis Drieghe, Wouter Duyck
The present study assessed intra- and cross-lingual neighborhood effects, using both a generalized lexical decision task and an analysis of a large-scale bilingual eye-tracking corpus (Cop, Dirix, Drieghe, & Duyck, 2016). Using new neighborhood density and frequency measures, the general lexical decision task yielded an inhibitory cross-lingual neighborhood density effect on reading times of second language words, replicating van Heuven, Dijkstra, and Grainger (1998). Reaction times for native language words were not influenced by neighborhood density or frequency but error rates showed cross-lingual neighborhood effects depending on target word frequency...
January 16, 2017: Journal of Experimental Psychology. Learning, Memory, and Cognition
https://www.readbyqxmd.com/read/28094239/performance-variation-due-to-stiffness-in-a-tuna-inspired-flexible-foil-model
#10
Mariel-Luisa N Rosic, Patrick J M Thornycroft, Kara L Feilich, Kelsey N Lucas, George V Lauder
Tuna are fast, economical swimmers in part due to their stiff, high aspect ratio caudal fins and streamlined bodies. Previous studies using passive caudal fin models have suggested that while high aspect ratio tail shapes such as a tuna's generally perform well, tail performance cannot be determined from shape alone. In this study, we analyzed the swimming performance of tuna-tail-shaped hydrofoils of a wide range of stiffnesses, heave amplitudes, and frequencies to determine how stiffness and kinematics affect multiple swimming performance parameters for a single foil shape...
January 17, 2017: Bioinspiration & Biomimetics
https://www.readbyqxmd.com/read/28093564/postoperative-conversion-disorder-presenting-as-inspiratory-stridor-and-hemiparesis-in-a-pediatric-patient
#11
Erik J Nelson, Jennifer Y Wu
BACKGROUND Postoperative conversion disorder is rare and has been reported. The diagnosis is usually made after all major organic causes have been ruled out. CASE REPORT We describe a case of a 13-year-old female who presented in the post-anesthesia care unit with acute-onset inspiratory stridor and unresponsiveness to verbal or painful stimuli after receiving a general anesthetic for upper endoscopy. Later in the post-anesthesia care unit, she presented with acute-onset right hemiplegia and sensory loss. She was first evaluated for causes of her stridor and unresponsiveness...
January 17, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28093257/selective-preservation-of-cholinergic-mecp2-rescues-specific-rett-syndrome-like-phenotypes-in-mecp2-stop-mice
#12
Huanhuan Zhou, Wei Wu, Ying Zhang, Haiyang He, Zhefeng Yuan, Zhiwei Zhu, Zhengyan Zhao
RTT is a neurodevelopmental disorder characterized by growth regression, motor dysfunction, stereotypic hand movements, and autism features. Typical Rett syndrome (RTT) is predominantly caused by mutations in X-linked MeCP2 gene which encodes methyl-CpG-binding protein 2 (MeCP2). The brain-abundant MeCP2 protein mainly functions as a transcriptional regulator for neurodevelopment-associated genes. Specific functions of MeCP2 in certain neuron types remain to be known. Although cholinergic system is an important modulating system in brain, how MeCP2 in cholinergic neurons contribute to RTT has not been clearly understood...
January 16, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28092958/moments-of-von-mises-and-fisher-distributions-and-applications
#13
Thomas Hillen, Kevin J Painter, Amanda C Swan, Albert D Murtha
The von Mises and Fisher distributions are spherical analogues to the Normal distribution on the unit circle and unit sphere, respectively. The computation of their moments, and in particular the second moment, usually involves solving tedious trigonometric integrals. Here we present a new method to compute the moments of spherical distributions, based on the divergence theorem. This method allows a clear derivation of the second moments and can be easily generalized to higher dimensions. In particular we note that, to our knowledge, the variance-covariance matrix of the three dimensional Fisher distribution has not previously been explicitly computed...
June 1, 2017: Mathematical Biosciences and Engineering: MBE
https://www.readbyqxmd.com/read/28092567/inter-joint-coordination-deficits-revealed-in-the-decomposition-of-endpoint-jerk-during-goal-directed-arm-movement-after-stroke
#14
Jozsef Laczko, Robert Arthur Scheidt, Lucia S Simo, Davide Piovesan
It is well-documented that neurological deficits after stroke can disrupt motor control processes that affect the smoothness of reaching movements. The smoothness of hand trajectories during multi-joint reaching depends on shoulder and elbow joint angular velocities and their successive derivatives as well as on the instantaneous arm configuration and its rate of change. Right-handed survivors of unilateral hemiparetic stroke and neurologically-intact control participants held the handle of a two-joint robot and made horizontal planar reaching movements...
January 16, 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28092560/diffeomorphic-multi-frame-non-rigid-registration-of-cell-nuclei-in-2d-and-3d-live-cell-images
#15
Marco Tektonidis, Karl Rohr
To gain a better understanding of cellular and molecular processes it is important to quantitatively analyze the motion of subcellular particles in live cell microscopy image sequences. Since generally the subcellular particles move and cell nuclei move as well as deform, it is important to decouple the movement of particles from that of the cell nuclei using nonrigid registration methods. We have developed a diffeomorphic multi-frame approach for non-rigid registration of cell nuclei in 2D and 3D live cell fluorescence microscopy images...
January 16, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28091936/task-specific-motor-rehabilitation-therapy-after-stroke-improves-performance-in-a-different-motor-task-translational-evidence
#16
M El Amki, P Baumgartner, O Bracko, A R Luft, S Wegener
While the stroke survivor with a motor deficit strives for recovery of all aspects of daily life movements, neurorehabilitation training is often task specific and does not generalize to movements other than the ones trained. In rodent models of post-stroke recovery, this problem is poorly investigated as the training task is often the same as the one that measures motor function. The present study investigated whether motor training by pellet reaching translates into enhancement of different motor functions in rats after stroke...
January 14, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/28089515/navigation-through-the-plasma-membrane-molecular-landscape-shapes-random-organelle-movement
#17
Alison R Dun, Gabriel J Lord, Rhodri S Wilson, Deirdre M Kavanagh, Katarzyna I Cialowicz, Shuzo Sugita, Seungmee Park, Lei Yang, Annya M Smyth, Andreas Papadopulos, Colin Rickman, Rory R Duncan
Eukaryotic plasma membrane organization theory has long been controversial, in part due to a dearth of suitably high-resolution techniques to probe molecular architecture in situ and integrate information from diverse data streams [1]. Notably, clustered patterning of membrane proteins is a commonly conserved feature across diverse protein families (reviewed in [2]), including the SNAREs [3], SM proteins [4, 5], ion channels [6, 7], and receptors (e.g., [8]). Much effort has gone into analyzing the behavior of secretory organelles [9-13], and understanding the relationship between the membrane and proximal organelles [4, 5, 12, 14] is an essential goal for cell biology as broad concepts or rules may be established...
January 9, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28088678/three-dimensional-lumbar-segment-movement-characteristics-during-paediatric-cerebral-palsy-gait
#18
D Kiernan, A Malone, T O'Brien, C K Simms
Kinematic analysis of the trunk during cerebral palsy (CP) gait has been well described. In contrast, movement of the lumbar spine is generally ignored. This is most likely due to the complex nature of the spine. As an alternative to using complex sensor protocols, this study modelled the lumbar region as a single segment and investigated characteristic patterns of movement during CP gait. In addition, the impact of functional level of impairment and the relationship with lower lumbar spinal loading were examined...
January 3, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28088552/antipredator-tactics-are-largely-maternally-controlled-in-goitered-gazelle-a-hider-ungulate
#19
David Blank
Predation is usually the primary cause of infant death among ungulate species, with the annual variation in the survival of neonates over their first summer a major factor in the population dynamics of many ungulates. Consequently, the maternal rearing strategy of a species is crucial for its reproductive success. Since the roles mothers and fawns play in the implementation of antipredator strategies in hider species have been poorly understood until now, this paper considers this behavior in the goitered gazelle, which is a typical hider species...
January 11, 2017: Behavioural Processes
https://www.readbyqxmd.com/read/28087402/accuracy-is-in-the-eyes-of-the-pathologist-the-visual-interpretive-process-and-diagnostic-accuracy-with-digital-whole-slide-images
#20
Tad T Brunyé, Ezgi Mercan, Donald L Weaver, Joann G Elmore
Digital whole slide imaging is an increasingly common medium in pathology, with application to education, telemedicine, and rendering second opinions. It has also made it possible to use eye tracking devices to explore the dynamic visual inspection and interpretation of histopathological features of tissue while pathologists review cases. Using whole slide images, the present study examined how a pathologist's diagnosis is influenced by fixed case-level factors, their prior clinical experience, and their patterns of visual inspection...
January 10, 2017: Journal of Biomedical Informatics
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