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https://www.readbyqxmd.com/read/29692001/all-cause-and-cause-specific-mortality-in-granulomatosis-with-polyangiitis-a-population-based-study
#1
Ju Ann Tan, Hyon K Choi, Hui Xie, Eric C Sayre, John M Esdaile, J Antonio Aviña-Zubieta
OBJECTIVE: To investigate all-cause and cause-specific mortality in patients with newly diagnosed granulomatosis with polyangiitis (GPA) between two calendar time periods, 1997-2004 and 2005-2012. METHODS: Using an administrative health database, we compared all incident cases of GPA to non-GPA controls matched based on sex, age and entry time. Study cohorts were divided into two sub-groups based on the year of diagnosis (i.e., early cohort 1997-2004 and late cohort 2005-2012)...
April 25, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29691997/mortality-after-endophthalmitis-following-contemporary-phacoemulsification-cataract-surgery
#2
Philip J Polkinghorne, Niall Crosby, Bia Kim, Charles McGhee, Sarah Welch, Andrew Riley, Philip J Polkinghorne
IMPORTANCE: To determine if endophthamitis following cataract surgery is linked to increased mortality. BACKGROUND: Increased mortality has been linked to patients with cataract and cataract surgery. We tested the hypothesis that post-cataract endophthalitis has a greater risk of death than pseudo-phakes who don't develop this complication. DESIGN: Case control study conducted in a tertiary public hospital. PARTICIPANTS: The study group comprised of 50 consecutive patients with post-cataract endophthalmitis and these were matched selected controls...
April 24, 2018: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/29691978/impact-of-time-since-diagnosis-and-mortality-rate-on-cancer-associated-venous-thromboembolism-the-scandinavian-thrombosis-and-cancer-stac-cohort
#3
Kristine Blix, Olga V Gran, Marianne T Severinsen, Suzanne C Cannegieter, Hilde Jensvoll, Kim Overvad, Jens Hammerstrøm, Anne Tjønneland, Inger A Naess, Sigrid K Braekkan, Frits R Rosendaal, Søren R Kristensen, John-Bjarne Hansen
BACKGROUND: Venous thromboembolism (VTE) is a common complication in cancer, and studies suggest that aggressive cancers harvest the highest risk of VTE. However, competing risk by death may result in over-estimation of VTE risk in cancers with high mortality. Therefore, we estimated the risk of VTE by cancer sites, accounting for the differential mortality between cancers. METHODS: The Scandinavian Thrombosis and Cancer cohort included 144 952 participants followed from 1993-1997 to 2008-2012...
April 25, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29691863/population-based-study-of-mortality-and-major-amputation-following-lower-limb-revascularization
#4
K Heikkila, I M Loftus, D C Mitchell, A S Johal, S Waton, D A Cromwell
BACKGROUND: The aim of this study was to estimate separate risks of major lower limb amputation and death following revascularization for peripheral artery disease (PAD) using competing risks analysis. METHODS: Routinely collected data from Hospital Episode Statistics (HES) were used to identify patients who underwent endovascular or open lower limb revascularization for PAD in England from 2005 to 2015. The primary outcomes were major lower limb amputation and death within 5 years of revascularization...
April 25, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29691834/prescription-and-predictors-of-post-stroke-antidepressant-treatment-a-population-based-study
#5
J K Mortensen, S P Johnsen, G Andersen
OBJECTIVES: Post-stroke depression and pathological crying are common and potentially serious complications after stroke and should be diagnosed and treated accordingly. Diagnosis and treatment probably rely on clinical experience and may pose certain challenges. We aimed to examine prescription and predictors of antidepressant treatment after ischemic stroke in a clinical setting. MATERIALS AND METHODS: In this registry-based follow-up study, consecutive ischemic stroke patients were identified from the Danish Stroke Registry, holding information on antidepressant treatment during admission in Aarhus County from 2003 to 2010...
April 24, 2018: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29691803/association-of-beta-blockers-with-survival-on-patients-presenting-with-acs-treated-with-pci-a-propensity-score-analysis-from-the-bleemacs-registry
#6
Fabrizio D'Ascenzo, Dario Celentani, Alessandro Brustio, Alberto Grosso, Sergio Raposeiras-Roubín, Emad Abu-Assi, Jose Paulo Simao Henriques, Jorge Saucedo, José Ramón González-Juanatey, Stephen B Wilton, Wouter J Kikkert, Iván Nuñez-Gil, Albert Ariza-Sole, Xiantao Song, Dimitrios Alexopoulos, Christoph Liebetrau, Tetsuma Kawaji, Zenon Huczek, Shao-Ping Nie, Toshiharu Fujii, Luis Correia, Masa-Aki Kawashiri, José María García-Acuña, Danielle Southern, Emilio Alfonso, Belén Terol, Alberto Garay, Dongfeng Zhang, Yalei Chen, Ioanna Xanthopoulou, Neriman Osman, Helge Möllmann, Hiroki Shiomi, Michal Kowara, Krzysztof Filipiak, Xiao Wang, Yan Yan, Jing-Yao Fan, Yuji Ikari, Takuya Nakahayshi, Kenji Sakata, Masakazu Yamagishi, Oliver Kalpak, Sasko Kedev, Claudio Moretti, Maurizio D'Amico, Fiorenzo Gaita
PURPOSE: The aim was to evaluate prognostic value of beta-blocker (BB) administration in acute coronary syndromes (ACS) patients in the percutaneous coronary intervention (PCI) era. METHODS AND RESULTS: The BleeMACS project is a multicenter, observational, retrospective registry enrolling patients with ACS worldwide in 15 hospitals. Patients discharged with BB therapy were compared to those discharged without a BB before and after propensity score with matching...
April 24, 2018: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/29691768/skin-cancer-following-solid-organ-transplantation-a-review-of-risk-factors-and-models-of-care
#7
REVIEW
Matthew D Howard, John C Su, Alvin H Chong
The number of solid organ transplants has been increasing annually worldwide. Advances in transplantation surgery and community awareness of organ donation have been key contributors. Combined with increased understanding of immunosuppression, there are a growing number of solid organ transplant recipients in the community as a result of improved long-term outcomes. There remains a high incidence of deaths worldwide post-transplant due to non-melanoma skin cancer (NMSC), which has greater morbidity and mortality in this population than in the general community...
April 24, 2018: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/29691706/low-concentrations-of-25-hydroxyvitamin-d-and-long-term-prognosis-of-copd-a-prospective-cohort-study
#8
Gitte Færk, Yunus Çolak, Shoaib Afzal, Børge G Nordestgaard
Role and importance of vitamin D deficiency in long-term prognosis of chronic obstructive pulmonary disease (COPD) still remains undetermined. We tested the hypothesis that among individuals with COPD, those with low concentrations of 25-hydroxyvitamin D have a poorer prognosis compared to those with normal concentrations. We studied 35,153 individuals from the general population aged 20-100 years with 25-hydroxyvitamin D measurements and spirometry, the Copenhagen City Heart Study [median follow-up 21 years (range 13 days-36 years)] and the Copenhagen General Population Study [7...
April 24, 2018: European Journal of Epidemiology
https://www.readbyqxmd.com/read/29691632/mathematical-modeling-of-climate-change-and-malaria-transmission-dynamics-a-historical-review
#9
REVIEW
Steffen E Eikenberry, Abba B Gumel
Malaria, one of the greatest historical killers of mankind, continues to claim around half a million lives annually, with almost all deaths occurring in children under the age of five living in tropical Africa. The range of this disease is limited by climate to the warmer regions of the globe, and so anthropogenic global warming (and climate change more broadly) now threatens to alter the geographic area for potential malaria transmission, as both the Plasmodium malaria parasite and Anopheles mosquito vector have highly temperature-dependent lifecycles, while the aquatic immature Anopheles habitats are also strongly dependent upon rainfall and local hydrodynamics...
April 24, 2018: Journal of Mathematical Biology
https://www.readbyqxmd.com/read/29691365/plasma-inflammatory-cytokines-and-survival-of-pancreatic-cancer-patients
#10
A Babic, N Schnure, N P Neupane, M M Zaman, N Rifai, M W Welch, L K Brais, D A Rubinson, V Morales-Oyarvide, C Yuan, S Zhang, E M Poole, B M Wolpin, M H Kulke, D A Barbie, K Wong, C S Fuchs, K Ng
OBJECTIVES: Inflammation and inflammatory conditions have been associated with pancreatic cancer risk and progression in a number of clinical, epidemiological, and animal model studies. The goal of the present study is to identify plasma markers of inflammation associated with survival of pancreatic cancer patients, and assess their joint contribution to patient outcome. METHODS: We measured circulating levels of four established markers of inflammation (C-reactive protein (CRP), interleukin-6 (IL-6), soluble tumor necrosis factor receptor type II (sTNF-RII), and macrophage inhibitory cytokine-1 (MIC-1)) in 446 patients enrolled in an ongoing prospective clinic-based study...
April 25, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/29691305/application-of-outpatient-cardiac-testing-among-emergency-department-patients-with-syncope
#11
Olivia G Cook, Muhammad A Mukarram, Soo-Min Kim, Kirtana Arcot, Marie-Joe Nemnom, Monica Taljaard, Marco L A Sivilotti, Brian H Rowe, Venkatesh Thiruganasambandamoorthy
OBJECTIVES: 2.6% of ED syncope patients will suffer cardiac serious adverse events (SAEs) within 30 days of disposition, and outpatient cardiac testing can improve patient safety. The objective is to determine whether outpatient cardiac testing for ED syncope patients is being appropriately ordered after discharge. To this end, we describe the proportion of high-risk and non-high (low and medium)-risk ED syncope patients as per the Canadian Syncope Risk Score (CSRS) who have a SAE after ED discharge, and the proportion referred for outpatient cardiac testing...
April 24, 2018: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29691174/ten-year-mortality-and-revision-after-total-knee-arthroplasty-in-morbidly-obese-patients
#12
Mina Tohidi, Susan B Brogly, Katherine Lajkosz, Heather J Grant, Elizabeth G VanDenKerkhof, Aaron R Campbell
BACKGROUND: Although morbid obesity has been associated with early surgical complications after total knee arthroplasty (TKA), evidence of long-term outcomes is limited. We conducted a population-based study to determine the association between morbid obesity and 10-year survival and revision surgery in patients undergoing primary TKA. METHODS: A cohort study of 9817 patients aged 18-60 years treated with primary TKA from April 1, 2002 to March 31, 2007 was conducted using Ontario administrative health-care databases of universal health-care coverage...
April 4, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29691168/predicting-failure-in-early-acute-prosthetic-joint-infection-treated-with-debridement-antibiotics-and-implant-retention-external-validation-of-the-klic-score
#13
Claudia A M Löwik, Paul C Jutte, Eduard Tornero, Joris J W Ploegmakers, Bas A S Knobben, Astrid J de Vries, Wierd P Zijlstra, Baukje Dijkstra, Alex Soriano, Marjan Wouthuyzen-Bakker
BACKGROUND: Debridement, antibiotics, and implant retention (DAIR) is a widely used treatment modality for early acute prosthetic joint infection (PJI). A preoperative risk score was previously designed for predicting DAIR failure, consisting of chronic renal failure (K), liver cirrhosis (L), index surgery (I), cemented prosthesis (C), and C-reactive protein >115 mg/L (KLIC). The aim of this study was to validate the KLIC score in an external cohort. METHODS: We retrospectively evaluated patients with early acute PJI treated with DAIR between 2006 and 2016 in 3 Dutch hospitals...
March 27, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29691157/transcatheter-aortic-valve-replacement-and-atrial-fibrillation-impact-of-antithrombotic-strategy-on-clinical-outcomes
#14
Samuel Hui, Robert Gooley, Hashrul N Rashid, Sarah Zaman
BACKGROUND: Antithrombotic recommendations following transcatheter aortic valve replacement (TAVR) are largely based on previous trial protocols. The efficacy and risk of anticoagulation has not been systematically assessed. The aim of this study was to determine the efficacy and safety of oral anticoagulation in patients with atrial fibrillation (AF) following TAVR with the Lotus Valve System (Boston Scientific, Malborough, MA, USA). METHODS: Consecutive patients with severe aortic stenosis who underwent Lotus valve implantation were prospectively recruited (n=164)...
April 4, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29691145/extended-endoscopic-endonasal-surgery-for-clival-chordoma-and-chondrosarcoma-our-experience-in-14-cases
#15
Diego Culebras, Jorge Torales, Luis Alberto Reyes, Luis Zapata, Sergio García, Pedro Roldán, Cristóbal Langdon, Issam Alobid, Joaquim Enseñat
OBJECTIVE: To report our experience in the management of chordoma and chondrosarcoma with extended endoscopic endonasal surgery. METHOD: We performed a retrospective analysis of a series of 14 patients with clival chordoma or chondrosarcoma who had extended endoscopic endonasal surgery from 2008 to 2016 performed by the same multidisciplinary team. RESULTS: We had fourteen patients (male/female 2:1), with a mean age of 49years for chordoma and 32 for chondrosarcoma...
April 21, 2018: Neurocirugía
https://www.readbyqxmd.com/read/29691115/beyond-total-mesorectal-excision-in-locally-advanced-rectal-cancer-with-organ-or-pelvic-side-wall-involvement
#16
A B Mariathasan, K Boye, K E Giercksky, B Brennhovd, H P Gullestad, H L Emblemsvåg, K K Grøholt, S Dueland, K Flatmark, S G Larsen
BACKGROUND: In locally advanced rectal cancer (LARC), beyond total mesorectal excision (bTME) is often necessary to obtain complete resection (R0). The aim of this study was to identify prognostic determinants and compare morbidity and survival in LARC cases requiring bTME or TME surgery. METHOD: Single centre cohort study of LARC cases where all patients received neoadjuvant radiotherapy (n = 332). Data was registered prospectively in an institutional database linked to the National Registry...
April 12, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29691103/the-risk-stratification-and-prognostic-prediction-value-of-procalcitonin-and-clinical-severity-scores-on-patients-with-community-acquired-pneumonia-in-emergency-department-prediction-value-of-procalcitonin-and-severity-scores-for-cap
#17
Haijiang Zhou, Shubin Guo, Tianfei Lan, Shuai Ma, Fang Zhang, Zhiling Zhao
OBJECTIVE: Community-acquired pneumonia (CAP) is a common presentation to the emergency department (ED) and has high mortality rates. The aim of our study is to investigate the risk stratification and prognostic prediction value of precalcitonin (PCT) and clinical severity scores on patients with CAP in ED. METHODS: 226 consecutive adult patients with CAP admitted in ED of a tertiary teaching hospital were enrolled. Demographic information and clinical parameters including PCT levels were analyzed...
March 21, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29690971/clinical-spectrum-and-outcome-of-cerebral-venous-sinus-thrombosis-in-children
#18
Iram Javed, Tipu Sultan, Zia Ur Rehman, Muhammad Rizwan Yaseen
OBJECTIVE: To determine clinical spectrum, neuroimaging finding and outcome of cerebral venous sinus thrombosis (CVST) in children. STUDY DESIGN: Descriptive and cross-sectional study. PLACE AND DURATION OF STUDY: Department of Paediatric Neurology, Children's Hospital and Institute of Child Health, Lahore, from 2015 to 2016. METHODOLOGY: Data was collected in a predesigned proforma by non-probability purposive sampling technique from all enrolled 32 patients fulfilling the inclusion criteria...
May 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29690932/a-retrospective-cohort-study-of-body-mass-index-and-survival-in-hiv-infected-patients-with-and-without-tb-co-infection
#19
Kogieleum Naidoo, Nonhlanhla Yende-Zuma, Stanton Augustine
BACKGROUND: High early morbidity and mortality following antiretroviral therapy (ART) initiation has been a distinguishing feature of ART programmes in resource limited settings (RLS) compared to high-income countries. This study assessed how well body mass index (BMI: kg/m2 ) correlated with survival among HIV infected patients with and without TB co-infection. METHODS: We retrospectively evaluated clinical data from 1000 HIV infected patients, among whom 389 were also co-infected with TB, between January 2008 and December 2010, in KwaZulu-Natal, South Africa...
April 25, 2018: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29690880/abnormal-pulmonary-function-tests-predict-the-development-of-radiation-induced-pneumonitis-in-advanced-non-small-cell-lung-cancer
#20
L Torre-Bouscoulet, W R Muñoz-Montaño, D Martínez-Briseño, F J Lozano-Ruiz, R Fernández-Plata, J A Beck-Magaña, C García-Sancho, A Guzmán-Barragán, E Vergara, M Blake-Cerda, L Gochicoa-Rangel, F Maldonado, M Arroyo-Hernández, O Arrieta
BACKGROUND: Radiation pneumonitis (RP) is a frequent complication of concurrent chemoradiotherapy (CCRT) and is associated with severe symptoms that decrease quality of life and might result in pulmonary fibrosis or death. The aim of this study is to identify whether pulmonary function test (PFT) abnormalities may predict RP in non-small cell lung cancer (NSCLC) patients. METHODS: A prospective multi-institutional study was conducted with locally advanced and oligometastatic NSCLC patients...
April 24, 2018: Respiratory Research
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