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https://www.readbyqxmd.com/read/29913516/medication-for-opioid-use-disorder-after-nonfatal-opioid-overdose-and-association-with-mortality-a-cohort-study
#1
Marc R Larochelle, Dana Bernson, Thomas Land, Thomas J Stopka, Na Wang, Ziming Xuan, Sarah M Bagley, Jane M Liebschutz, Alexander Y Walley
Background: Opioid overdose survivors have an increased risk for death. Whether use of medications for opioid use disorder (MOUD) after overdose is associated with mortality is not known. Objective: To identify MOUD use after opioid overdose and its association with all-cause and opioid-related mortality. Design: Retrospective cohort study. Setting: 7 individually linked data sets from Massachusetts government agencies...
June 19, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29913439/lncrna-lcpat1-mediates-smoking-particulate-matter-2-5-induced-cell-autophagy-and-epithelial-mesenchymal-transition-in-lung-cancer-cells-via-rcc2
#2
Hongyan Lin, Xiaohong Zhang, Nannan Feng, Ruoyang Wang, Weituo Zhang, Xiaobei Deng, Yu Wang, Xiao Yu, Xiaofei Ye, Lei Li, Ying Qian, Herbert Yu, Biyun Qian
BACKGROUND/AIMS: Ecological studies have shown that air pollution and prevalence of cigarette smoking are positively correlated. Evidence also suggests a synergistic effect of cigarette smoking and PM2.5 exposure (Environmental Particulate Matter ≤ 2.5 µm in diameter) on lung cancer risk. We aimed to evaluate the interaction between smoking prevalence and PM2.5 pollution in relation to lung cancer mortality and determine its underlying mechanisms in vitro. METHODS: "MOVER" method was used to analyze the interaction between smoking prevalence and PM2...
June 15, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29913438/race-age-and-gender-based-characteristics-and-toxicities-of-targeted-therapies-on-phase-i-trials
#3
Taofeek K Owonikoko, Adeniyi K Busari, Sungjin Kim, Zhengjia Chen, Adebowale Akintayo, Colleen Lewis, Bradley C Carthon, Olatunji B Alese, Bassel F El-Rayes, Suresh S Ramalingam, R Donald Harvey
BACKGROUND: The impact of age-, gender-, and race-based differences on safety and efficacy in phase I clinical trials has not been well studied. METHODS: We analyzed data from phase I clinical trials evaluating targeted biologic agents in patients with advanced solid malignancies. Race and gender distribution of enrolled patients was compared to the referral population demographics at the city, metro, and state levels. The association between age, gender, and race with type, frequency, and severity of treatment-emergent toxicities and clinical benefit was assessed using univariate and multivariable models...
June 18, 2018: Oncology
https://www.readbyqxmd.com/read/29913365/the-prevalence-and-correlates-of-anticoagulant-rodenticide-exposure-in-non-target-predators-and-scavengers-in-finland
#4
Elina Koivisto, Andrea Santangeli, Pertti Koivisto, Tapio Korkolainen, Timo Vuorisalo, Ilpo K Hanski, Iida Loivamaa, Sanna Koivisto
The most common rodent control method worldwide is anticoagulant rodenticides (ARs), which cause death by internal bleeding. ARs can transfer to non-target predators via secondary exposure, i.e. by consuming contaminated rodents. Here we quantify the prevalence of seven AR substances in the liver tissues of altogether 17 mammalian or avian predator or scavenger species in Finland. In addition, we identify the environmental and biological factors potentially linked to secondary AR poisoning. No previous AR screenings have been conducted in the country, despite the widespread use of ARs and their potential impacts on the high levels of the ecosystem food chain...
June 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29913241/genetic-risk-analysis-for-an-individual-according-to-the-theory-of-programmed-onset-illustrated-by-lung-and-liver-cancers
#5
Xia Qi, Yuanjun Yu, Na Ji, Sashuang Ren, Yongcheng Xu, Hui Liu
OBJECTIVE: To investigate cancer association in the genome and the genetic risk of death from major cancers according to the theory of programmed onset for an individual. METHODS: Alleles of 15 randomly selected short tandem repeat (STR) loci, including D6S1043, D12S391, CSF1PO, D7S820, D2S1338, D3S1358, vWA, FGA, D8S1179, D21S11, D18S51, D5S818, D13S317, D16S539 and D19S433, were determined in 50 patients with lung cancer and 50 patients with liver cancer. The onset age of patients with and without the alleles was compared with Cox regression...
June 15, 2018: Gene
https://www.readbyqxmd.com/read/29913200/increased-t-cell-immunosenescence-and-accelerated-maturation-phenotypes-in-older-kidney-transplant-recipients
#6
J M Schaenman, M Rossetti, T Sidwell, V Groysberg, G Sunga, Y Korin, E Liang, X Zhou, B Abdallah, E Lum, S Bunnapradist, T Pham, G Danovitch, E F Reed
Older kidney transplant recipients experience increased rates of infection and death, and less rejection, compared with younger patients. However, little is known about immune dysfunction in older compared with younger kidney transplant recipients and whether it is associated with infection. We evaluated T cell phenotypes including maturation, immune senescence, and exhaustion in a novel investigation into differences in older compared with younger patients receiving identical immune suppression regimens. We evaluated PBMC from 60 kidney transplant recipients (23 older and 37 matched younger patients) by multiparameter immune phenotyping...
June 15, 2018: Human Immunology
https://www.readbyqxmd.com/read/29912783/impact-of-serum-lipoprotein-a-on-endothelium-dependent-coronary-vasomotor-response-assessed-by-intracoronary-acetylcholine-provocation
#7
Ahmed Mashaly, Seung-Woon Rha, Byoung G Choi, Man J Baek, Yang G Ryu, Se Y Choi, Jae K Byun, Kareem Abdelshafi, Yoonjee Park, Won Y Jang, Kim Woohyeun, Eun J Park, Jah Yeon Choi, Jin O Na, Cheol U Choi, Hong E Lim, Eung J Kim, Chang G Park, Hong S Seo
BACKGROUND: Lipoprotein(a) [Lp(a)] is an independent risk factor for atherosclerotic vascular disease. However, there are limited data regarding the impact of Lp(a) levels on the incidence and severity of endothelium-dependent coronary vasomotor response. PATIENTS AND METHODS: A total of 2416 patients without significant coronary artery lesion (<50% stenosis) by coronary angiography and underwent acetylcholine (ACh) provocation test were enrolled and categorized according to their serum Lp(a) level into four quartile groups: less than 6...
June 16, 2018: Coronary Artery Disease
https://www.readbyqxmd.com/read/29912763/factors-associated-with-adenoma-detection-in-propofol-sedated-patients
#8
Hui Jia, Malcolm Koo, Yu-Hsi Hsieh, Chih-Wei Tseng, Chi-Tan Hu, Linhui Zhang, Tao Dong, Yanglin Pan, Felix W Leung
GOALS: To assess the factors associated with adenoma detection in propofol-sedated patients. BACKGROUNDS: Low adenoma detection rate (ADR) are linked to increased risk of interval cancer and related deaths. Compared with air insufflation (AI) colonoscopy, the method of water exchange (WE) significantly decreased insertion pain and increased ADR in unsedated patients. Deep sedation with propofol has been increasingly used in colonoscopy. One report suggested that WE significantly increased ADR in propofol-sedated patients, but the factors associated with adenoma detection were not analyzed...
June 15, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29912712/reemergence-of-reston-ebolavirus-in-cynomolgus-monkeys-the-philippines-2015
#9
Catalino Demetria, Ina Smith, Titus Tan, Daniel Villarico, Edson Michael Simon, Rex Centeno, Mary Tachedjian, Satoshi Taniguchi, Masayuki Shimojima, Noel Lee J Miranda, Mary Elizabeth Miranda, Melissa Marie R Rondina, Rowena Capistrano, Amado Tandoc, Glenn Marsh, Debbie Eagles, Ramses Cruz, Shuetsu Fukushi
In August 2015, a nonhuman primate facility south of Manila, the Philippines, noted unusual deaths of 6 cynomolgus monkeys (Macaca fascicularis), characterized by generalized rashes, inappetence, or sudden death. We identified Reston ebolavirus (RESTV) infection in monkeys by using serologic and molecular assays. We isolated viruses in tissues from infected monkeys and determined viral genome sequences. RESTV found in the 2015 outbreak is genetically closer to 1 of the 4 RESTVs that caused the 2008 outbreak among swine...
July 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29912422/age-and-outcomes-following-guided-de-escalation-of-antiplatelet-treatment-in-acute-coronary-syndrome-patients-undergoing-percutaneous-coronary-intervention-results-from-the-randomized-tropical-acs-trial
#10
Dirk Sibbing, Lisa Gross, Dietmar Trenk, Claudius Jacobshagen, Tobias Geisler, Martin Hadamitzky, Béla Merkely, Róbert Gábor Kiss, András Komócsi, Radoslaw Parma, Stephan B Felix, Franz-Josef Neumann, Jörg Hausleiter, Monika Baylacher, Lukasz Koltowski, Julinda Mehilli, Kurt Huber, Zenon Huczek, Dániel Aradi, Steffen Massberg
Aims: Guided de-escalation of P2Y12-inhibitor treatment was recently identified as an effective alternative treatment strategy in acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention. Safety and efficacy of this strategy may differ in relation to patient's age. This pre-specified analysis of the TROPICAL-ACS trial aimed to assess the impact of age on clinical outcomes following guided de-escalation of antiplatelet treatment in ACS patients. Methods and results: Patients were randomly assigned in a 1:1 fashion to either standard treatment with prasugrel for 12 months (control group) or to a guided de-escalation regimen (1 week prasugrel followed by 1 week clopidogrel and platelet function testing guided maintenance therapy with clopidogrel or prasugrel from day 14 after hospital discharge; guided de-escalation group)...
June 14, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29912415/primary-melanoma-histologic-subtype-impact-on-survival-and-response-to-therapy
#11
Michael Lattanzi, Yesung Lee, Danny Simpson, Una Moran, Farbod Darvishian, Randie H Kim, Eva Hernando, David Polsky, Doug Hanniford, Richard Shapiro, Russell Berman, Anna C Pavlick, Melissa A Wilson, Tomas Kirchhoff, Jeffrey S Weber, Judy Zhong, Iman Osman
Background: Two primary histologic subtypes, superficial spreading melanoma (SSM) and nodular melanoma (NM), comprise the majority of all cutaneous melanomas. NM is associated with worse outcomes, which have been attributed to increased thickness at presentation, and it is widely expected that NM and SSM would exhibit similar behavior once metastasized. Herein, we tested the hypothesis that primary histologic subtype is an independent predictor of survival and may impact response to treatment in the metastatic setting...
June 15, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29912335/cessation-of-cigarette-smoking-and-the-impact-on-cancer-incidence-in-hiv-positive-persons-the-d-a-d-study
#12
Leah Shepherd, Lene Ryom, Matthew Law, Kathy Petoumenos, Camilla Ingrid Hatleberg, Antonella d'Arminio Monforte, Caroline Sabin, Mark Bower, Fabrice Bonnet, Peter Reiss, Stephane de Wit, Christian Pradier, Rainer Weber, Wafaa El-Sadr, Jens Lundgren, Amanda Mocroft
Background: Cancers are a major source of morbidity and mortality for HIV-positive persons on combination antiretroviral therapy, while the clinical benefits of smoking cessation are not well established. Methods: Participants were followed from 1 January 2004 until first cancer diagnosis, death, or 1 February 2016. Smoking status was defined as ex (<1,1-2,2-3,3-5,>5 years since stopping), current, and never smokers. Outcomes considered were any cancer, lung cancer, other smoking-related excluding lung and smoking-unrelated cancers...
June 14, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29912256/-loss-of-risk-perception-to-zoonoses-and-the-figure-of-community-dog
#13
Claudio A Rojas, Carlos F Lüders, Carlos Manterola, Myriam Velazco
Dogs may cause zoonoses and damages; especially when we accept as normal some dangerous behavior, losing the perception of disease risk. The purpose of this review was to demonstrate that the presence of stray dogs as well as community dogs, are public health hazard. Through sustainable epidemiological information, we believe this measure could prevent it from spreading. Dog's aggressiveness regulates its social relationships through submission or dominance; those characteristics are difficult to be recognized by human population...
April 2018: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/29912095/combined-biomarkers-predict-acute-mortality-among-critically-ill-patients-with-suspected-sepsis
#14
Brendan J Kelly, Ebbing Lautenbach, Irving Nachamkin, Susan E Coffin, Jeffrey S Gerber, Barry D Fuchs, Charles Garrigan, Xiaoyan Han, Warren B Bilker, Jacqueleen Wise, Pam Tolomeo, Jennifer H Han
OBJECTIVES: Sepsis is associated with high early and total in-hospital mortality. Despite recent revisions in the diagnostic criteria for sepsis that sought to improve predictive validity for mortality, it remains difficult to identify patients at greatest risk of death. We compared the utility of nine biomarkers to predict mortality in subjects with clinically suspected bacterial sepsis. DESIGN: Cohort study. SETTING: The medical and surgical ICUs at an academic medical center...
July 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29912047/long-term-outcomes-and-risk-factors-after-adult-living-donor-liver-transplantation
#15
Daisuke Imai, Tomoharu Yoshizumi, Kazuhito Sakata, Toru Ikegami, Shinji Itoh, Noboru Harada, Takashi Motomura, Takeo Toshima, Yohei Mano, Yuji Soejima, Yoshihiko Maehara
BACKGROUND: Although risk factors for the long-term mortality of liver transplantation are well described, there is a lack of detailed study regarding these factors for adult living donor liver transplantation (LDLT). METHODS: We retrospectively analyzed 528 adult LDLT recipients in our hospital. The risk factors were analyzed for overall deaths >5 years post-LDLT. RESULTS: Over the 20-year follow-up, 137 patients died. Patient survival at 1, 3, 5, and 10 years post-LDLT was 87...
June 13, 2018: Transplantation
https://www.readbyqxmd.com/read/29912046/changes-in-utilization-and-discard-of-hcv-antibody-positive-deceased-donor-kidneys-in-the-era-of-direct-acting-antiviral-therapy
#16
Mary G Bowring, Lauren M Kucirka, Allan B Massie, Tanveen Ishaque, Sunjae Bae, Ashton A Shaffer, Jacqueline Garonzik Wang, Mark Sulkowski, Niraj Desai, Dorry L Segev, Christine M Durand
BACKGROUND: The availability of direct-acting antiviral (DAA) therapy might have impacted use of HCV-infected (HCV+) deceased-donor kidneys for transplantation. METHODS: We used 2005-2018 SRTR data to identify 18 936 candidates willing to accept HCV+ kidneys and 3348 HCV+ recipients of HCV+ kidneys. We compared willingness to accept, utilization, discard, and posttransplant outcomes associated with HCV+ kidneys between 2 treatment eras (Interferon [IFN] era: 1/1/2005-12/5/2013 versus DAA era: 12/6/2013-8/2/2018)...
June 13, 2018: Transplantation
https://www.readbyqxmd.com/read/29912045/liver-perfusate-natural-killer-cells-from-deceased-brain-donors-and-association-with-acute-cellular-rejection-after-liver-transplantation-a-time-to-rejection-analysis
#17
Duilio Pagano, Ester Badami, Pier Giulio Conaldi, Aurelio Seidita, Fabio Tuzzolino, Marco Barbàra, Fabrizio di Francesco, Alessandro Tropea, Rosa Liotta, Gaia Chiarello, Angelo Luca, Salvatore Gruttadauria
BACKGROUND: The ability to predict which recipients will successfully complete their posttransplant clinical course, is crucial for liver transplant (LT) programs. The assessment of natural killer (NK) cell subset determined by flow cytometry from a monocentric series of consecutive liver perfusates (LPs) could help identify risk factors portending adverse LT outcomes. METHODS: LPs were collected during the back-table surgical time after the procurement procedures for donors after brain death (DBDs)...
June 13, 2018: Transplantation
https://www.readbyqxmd.com/read/29912040/incidence-and-outcomes-of-positive-donor-rim-cultures-and-infections-in-the-cornea-preservation-time-study
#18
Shahzad I Mian, Anthony J Aldave, Elmer Y Tu, Brandon D Ayres, Bennie H Jeng, Marian S Macsai, Michael L Nordlund, Jeffrey G Penta, Sudeep Pramanik, Loretta B Szczotka-Flynn, Allison R Ayala, Wendi Liang, Maureen G Maguire, Jonathan H Lass
PURPOSE: To assess donor rim culture results and outcomes of ocular infections in the Cornea Preservation Time Study (CPTS). METHODS: Donor corneal rim cultures were optional. Donor characteristics were assessed for association with positive cultures using the Fisher exact test and Poisson regression analyses. Incidence rates of ocular infections were estimated, and 95% confidence intervals were calculated. RESULTS: Cultures were performed in 784 (58...
June 14, 2018: Cornea
https://www.readbyqxmd.com/read/29911818/the-opioid-crisis-in-canada-a-national-perspective
#19
REVIEW
Lisa Belzak, Jessica Halverson
INTRODUCTION: This review provides a national summary of what is currently known about the Canadian opioid crisis with respect to opioid-related deaths and harms and potential risk factors as of December 2017. METHODS: We reviewed all public-facing opioid-related surveillance or epidemiological reports published by provincial and territorial ministries of health and chief coroners' or medical examiners' offices. In addition, we reviewed publications from federal partners and reports and articles published prior to December 2017...
June 2018: Health Promotion and Chronic Disease Prevention in Canada
https://www.readbyqxmd.com/read/29911388/reimplantation-of-an-anomalous-left-coronary-artery-with-a-malignant-course
#20
Yutaka Imoto, Tomoyuki Matsuba, Hideaki Kanda, Yuki Ogata, Shuji Nagatomi, Kentaro Ueno
A 14-year-old boy was diagnosed with an anomalous left coronary artery coursing between the ascending aorta and the main pulmonary artery and associated with a single coronary ostium. Owing to the high risk of sudden cardiac death, surgery was performed although he was asymptomatic with no sign of myocardial ischemia. Reimplantation of an anomalous left coronary artery is generally considered difficult because an aortic cuff is unavailable for coronary anastomosis; however, we accomplished a successful direct reimplantation in this patient...
January 1, 2018: Asian Cardiovascular & Thoracic Annals
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