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https://www.readbyqxmd.com/read/28727957/awareness-of-state-legislation-on-naloxone-accessibility-associated-with-willingness-to-prescribe-naloxone
#1
Olihe N Okoro, Karen M Bastianelli, Ya-Feng Wen, Elisabeth F Bilden, Brian K Konowalchuk, Mark E Schneiderhan
BACKGROUND: Increasing rates of opioid-related deaths, state naloxone-legislation changes, and negativity prompted investigation of predictive factors associated with willingness to prescribe naloxone to populations at risk of overdose including knowledge of risk factors, assessment of persons at risk, awareness of legislative changes, perceptions of professional responsibility, and confidence around naloxone prescribing and distribution. METHODS: Cross-sectional, web-based, anonymous, voluntary survey to prescribers of two regional healthcare systems serving urban and rural North Dakota, northern Minnesota, and northwestern Wisconsin...
July 20, 2017: Substance Abuse
https://www.readbyqxmd.com/read/28727900/head-midline-position-for-preventing-the-occurrence-or-extension-of-germinal-matrix-intraventricular-hemorrhage-in-preterm-infants
#2
REVIEW
Olga Romantsik, Maria Grazia Calevo, Matteo Bruschettini
BACKGROUND: Preterm birth is known to constitute the major risk factor for development of germinal matrix-intraventricular hemorrhage (GM-IVH). Head position may affect cerebral hemodynamics and thus may be involved indirectly in development of GM-IVH. Turning the head toward one side may functionally occlude jugular venous drainage on the ipsilateral side while increasing intracranial pressure and cerebral blood volume. Thus, it has been suggested that cerebral venous pressure is reduced and hydrostatic brain drainage improved if the patient is in supine midline position with the bed tilted 30°...
July 20, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28727682/racial-and-ethnic-differences-in-homicides-of-adult-women-and-the-role-of-intimate-partner-violence-united-states-2003-2014
#3
Emiko Petrosky, Janet M Blair, Carter J Betz, Katherine A Fowler, Shane P D Jack, Bridget H Lyons
Homicide is one of the leading causes of death for women aged ≤44 years.* In 2015, homicide caused the death of 3,519 girls and women in the United States. Rates of female homicide vary by race/ethnicity (1), and nearly half of victims are killed by a current or former male intimate partner (2). To inform homicide and intimate partner violence (IPV) prevention efforts, CDC analyzed homicide data from the National Violent Death Reporting System (NVDRS) among 10,018 women aged ≥18 years in 18 states during 2003-2014...
July 21, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28727288/complications-preceding-early-deaths-in-black-and-white-children-with-acute-myeloid-leukemia
#4
Lena E Winestone, Kelly D Getz, Tamara P Miller, Yimei Li, Yuan-Shung Huang, Alix E Seif, Brian T Fisher, Richard Aplenc
Black patients have a twofold increased risk of induction mortality compared to White patients with acute myeloid leukemia (AML). We reviewed diagnosis and billing data from Pediatric Health Information System for 28 AML Induction I deaths to investigate conditions preceding death in White and Black patients. Half of deaths occurred within 10 days of initial diagnostic admission. Respiratory, cardiac, renal, and infectious complications were common prior to both White and Black deaths. Deaths in White patients were more commonly preceded by intracranial hemorrhage compared to deaths in Black patients...
July 20, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28727287/weighing-the-risks-morbid-obesity-and-diabetes-are-associated-with-increased-risk-of-death-on-the-liver-transplant-waiting-list
#5
Ani A Kardashian, Jennifer L Dodge, John Roberts, Danielle Brandman
Obesity is a growing problem in liver transplant (LT) candidates, paralleling the U.S. obesity epidemic and increase in LT for nonalcoholic steatohepatitis (NASH). While post-LT survival appears to be similar in obese and non-obese patients, data is scarce regarding risk of waitlist dropout in patients with morbid obesity (BMI≥40 kg/m(2) ). We examined the impact of obesity on waitlist mortality and evaluated predictors of dropout in LT candidates with morbid obesity or NASH METHODS: Competing risk analyses were performed in candidates listed between 3/2002-12/2013 to evaluate predictors of waitlist removal or death...
July 20, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28727166/hepatocytes-contribute-to-residual-glucose-production-in-a-mouse-model-for-glycogen-storage-disease-type-ia
#6
Brenda S Hijmans, Andreas Boss, Theo H van Dijk, Maud Soty, Henk Wolters, Elodie Mutel, Albert K Groen, Terry G J Derks, Gilles Mithieux, Arend Heerschap, Dirk-Jan Reijngoud, Fabienne Rajas, Maaike H Oosterveer
It is a longstanding enigma how glycogen storage disease (GSD) type I patients retain a limited capacity for endogenous glucose production (EGP) despite the loss of glucose-6-phosphatase (G6Pase) activity. Insight into the source of residual EGP is of clinical importance given the risk of sudden death in these patients, but so far contradictory mechanisms have been proposed. We investigated G6Pase-independent EGP in hepatocytes isolated from a liver-specific GSD Ia mouse model (L-G6pc(-/-) mice), and performed real-time analysis of hepatic glucose fluxes and glycogen metabolism in L-G6pc(-/-) mice using state-of-the-art stable isotope methodologies...
July 20, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28727137/national-evaluation-of-multidisciplinary-quality-metrics-for-head-and-neck-cancer
#7
John D Cramer, Sedona E Speedy, Robert L Ferris, Alfred W Rademaker, Urjeet A Patel, Sandeep Samant
BACKGROUND: The National Quality Forum has endorsed quality-improvement measures for multiple cancer types that are being developed into actionable tools to improve cancer care. No nationally endorsed quality metrics currently exist for head and neck cancer. METHODS: The authors identified patients with surgically treated, invasive, head and neck squamous cell carcinoma in the National Cancer Data Base from 2004 to 2014 and compared the rate of adherence to 5 different quality metrics and whether compliance with these quality metrics impacted overall survival...
July 20, 2017: Cancer
https://www.readbyqxmd.com/read/28727007/best-management-practices-for-newly-weaned-calves-for-improved-health-and-well-being
#8
B K Wilson, C J Richards, D L Step, C R Krehbiel
Morbidity and mortality in newly weaned calves resulting from bovine respiratory disease (BRD) continue to be the most significant problems facing the beef industry. Morbidity attributed to BRD accounts for approximately 75% of total feedlot morbidity. Several experiments have documented the economic impacts of BRD. Direct costs attributable to BRD include death loss, treatment and labor costs, and prevention costs, while indirect costs associated with BRD include decreased growth performance and feed efficiency, increased days on feed, and decreased carcass merit and market value...
May 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28726980/interdependence-between-osteoprotegerin-and-active-von-willebrand-factor-in-long-term-cardiovascular-mortality-prediction-in-patients-undergoing-percutaneous-coronary-intervention
#9
Jolanta Siller-Matula, Irene M Lang, Christian Schoergenhofer, Mark Roest, Bernd Jilma
The interdependence of the predictive accuracy of serum osteoprotegerin (OPG) and von Willebrand factor (vWF) levels for long-term cardiovascular outcomes has not been investigated so far. This was a prospective observational cohort study in 361 patients with coronary artery disease undergoing percutaneous coronary intervention (PCI). Baseline levels of OPG, vWF, active vWF (act vWF) and ristocetin cofactor activity (vWF:RICO) were measured. Cardiovascular mortality was recorded over a median of five years...
July 20, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28726785/jun-is-important-for-ocular-hypertension-induced-retinal-ganglion-cell-degeneration
#10
Stephanie B Syc-Mazurek, Kimberly A Fernandes, Richard T Libby
Ocular hypertension, a major risk factor for glaucoma, is thought to trigger glaucomatous neurodegeneration through injury to retinal ganglion cell (RGC) axons. The molecular signaling pathway leading from ocular hypertension to RGC degeneration, however, is not well defined. JNK signaling, a component of the mitogen-activated protein kinase (MAPK) family, and its canonical target, the transcription factor JUN, have been shown to regulate neurodegeneration in many different systems. JUN is expressed after glaucoma-relevant injuries and Jun deficiency protects RGCs after mechanical injury to the optic nerve...
July 20, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28726654/the-safety-and-efficacy-of-amiodarone-and-carvedilol-combination-in-treatment-of-patients-with-severe-cardiac-rhythm-disorders
#11
E Tsetskhladze, I Khintibidze
Different arrhythmias are cause of sudden death in many patients with heart failure. Amiodarone is usually used for prevent this arrhythmias, but it is not drug of choice for treatment the patients with heart failure. We retrospectively analyzed 142 patients with moderate and severe heart failure and history of myocardial infarction. These patients have received amiodarone, carvedilol or combination of these two medications together with standard therapy. In our retrospective analysis, the combination therapy with Amiodarone and Carvedilol had highly significant decrease arrhythmic death compare with carvedilol and amiodarone groups...
June 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28726625/risk-for-death-among-children-with-pneumonia-afghanistan
#12
Rahmani Zabihullah, Bhim G Dhoubhadel, Ferogh A Rauf, Sahab A Shafiq, Motoi Suzuki, Kiwao Watanabe, Lay M Yoshida, Michio Yasunami, Salihi Zabihullah, Christopher M Parry, Rabi Mirwais, Koya Ariyoshi
In Afghanistan, childhood deaths from pneumonia are high. Among 639 children at 1 hospital, the case-fatality rate was 12.1%, and 46.8% of pneumococcal serotypes detected were covered by the 13-valent vaccine. Most deaths occurred within 2 days of hospitalization; newborns and malnourished children were at risk. Vaccination could reduce pneumonia and deaths.
August 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28726613/human-metapneumovirus-and-other-respiratory-viral-infections-during-pregnancy-and-birth-nepal
#13
Jennifer L Lenahan, Janet A Englund, Joanne Katz, Jane Kuypers, Anna Wald, Amalia Magaret, James M Tielsch, Subarna K Khatry, Stephen C LeClerq, Laxman Shrestha, Mark C Steinhoff, Helen Y Chu
Human metapneumovirus (HMPV) is a respiratory virus that can cause severe lower respiratory tract disease and even death, primarily in young children. The incidence and characteristics of HMPV have not been well described in pregnant women. As part of a trial of maternal influenza immunization in rural southern Nepal, we conducted prospective, longitudinal, home-based active surveillance for febrile respiratory illness during pregnancy through 6 months postpartum. During 2011-2014, HMPV was detected in 55 of 3,693 women (16...
August 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28726475/perceived-physical-activity-and-mortality-evidence-from-three-nationally-representative-u-s-samples
#14
Octavia H Zahrt, Alia J Crum
OBJECTIVE: This research sought to examine the relationship of individuals' perceptions about their level of physical activity with mortality outcomes at the population level. METHOD: This study used 3 nationally representative samples with a total sample size of 61,141 U.S. adults (weighted N = 476 million). Data from the 1990 National Health Interview Survey (NHIS) and the 1999-2002/2003-2006 National Health and Nutrition Examination Survey (NHANES) were linked to prospective National Death Index mortality data through 2011, yielding follow-up periods of up to 21 years...
July 20, 2017: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/28726471/the-impact-of-medication-nonadherence-on-the-relationship-between-mortality-risk-and-depression-in-heart-failure
#15
Emily C Gathright, Mary A Dolansky, John Gunstad, Joseph D Redle, Richard A Josephson, Shirley M Moore, Joel W Hughes
OBJECTIVE: Heart failure affects more than 5 million U.S. adults, and approximately 20% of individuals with heart failure experience depressive symptoms. Depression is detrimental to prognosis in heart failure, conferring approximately a 2-fold increase in mortality risk. Medication nonadherence may help explain this relationship because depressed patients are less likely to adhere to the medication regimen. METHOD: Depression, electronically monitored medication adherence, and mortality were measured in a sample of 308 patients with heart failure participating in a study of self-management behavior...
July 20, 2017: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/28725995/intra-aortic-balloon-pumping-and-thrombocytopenia-in-patients-with-acute-coronary-syndrome-incidence-risk-factors-and-prognosis
#16
Z Sheng, H Zhao, H Yan, S Jiang, Y Guan, Y Zhang, L Song, C Liu, P Zhou, K Liu, J Liu, Y Tan
BACKGROUND: Thrombocytopenia is a frequently encountered phenomenon during intra-aortic balloon pumping (IABP), which may limit its prolonged utilization. The aim of the study was to explore the risk factors and clinical implications of IABP-associated thrombocytopenia in patients with acute coronary syndrome (ACS). METHODS: We retrospectively analyzed the data of 222 patients with ACS undergoing invasive treatment strategy supported by IABP. The incidence and risk factors of IABP-associated thrombocytopenia, and the association between thrombocytopenia and relevant clinical endpoints (in-hospital death, bleeding according to the TIMI scale, and thromboembolic events), were analyzed...
July 19, 2017: Herz
https://www.readbyqxmd.com/read/28725577/standards-for-mri-reporting-the-evolution-to-pi-rads-v-2-0
#17
REVIEW
Michael Spektor, Mahan Mathur, Jeffrey C Weinreb
Prostate cancer (PCa) remains a leading cause of death in the United States, but the vast majority of men diagnosed with PCa will die from other causes. While historically the capability of assessing the risk of life-threatening versus indolent PCa has relied heavily on serum prostate-specific antigen (PSA) and transrectal ultrasound (TRUS), multiparametric magnetic resonance imaging (mpMRI) has emerged as the leading tool for detection and characterization of clinically significant PCa. However, wide variations and lack of standardization of mpMRI data acquisition, interpretation, and reporting have hampered its progress...
June 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28725564/post-partum-streptococcal-toxic-shock-syndrome-associated-with-necrotizing-fasciitis
#18
Wei Chuan Chua, Mohd Zulfakar Mazlan, Saedah Ali, Sanihah Che Omar, Wan Mohd Nazaruddin Wan Hassan, S Praveena Seevaunnantum, Rhendra Hardy Mohd Zaini, Mohd Hasyizan Hassan, Alwi Muhd Besari, Zaidah Abd Rahman, Zeti Norfidiyati Salmuna Ayub, Sabrina Abd Ghani, Normalinda Yaacob, Wan Rosilawati Wan Rosli
We report a fatal case of post-partum streptococcal toxic shock syndrome in a patient who was previously healthy and had presented to the emergency department with an extensive blistering ecchymotic lesions over her right buttock and thigh associated with severe pain. The pregnancy had been uncomplicated, and the mode of delivery had been spontaneous vaginal delivery with an episiotomy. She was found to have septicemic shock requiring high inotropic support. Subsequently, she was treated for necrotizing fasciitis, complicated by septicemic shock and multiple organ failures...
2017: IDCases
https://www.readbyqxmd.com/read/28725327/prevalence-of-undiagnosed-cardiovascular-risk-factors-in-adults-aged-20-40-a-cross-sectional-study-in-2016-in-jeddah-saudi-arabia
#19
Faisal Saed Alharthi, Jamilah Saad Alrahimi, Abdulrahman Ali Alotaibi, Daniah Ahmed Alhamdi, Bashair Mohammed Ibrahim, Yasmina Aymen Badeeb
BACKGROUND: Cardiovascular diseases (CVDs) are the first leading cause of death worldwide. In Saudi Arabia, CVDs are the major killers with a mortality rate of 46%. CVD risk factors are not exclusive to old populations. Thus, the purpose of this study was to approximately find the prevalence of these risk factors, particularly high blood pressure (HBP), high blood glucose (HBG), obesity, and smoking. METHODS: This cross-sectional was conducted in May 2016 and took place in the Ambulatory Care Center of King Abdulaziz Medical City, Jeddah...
June 2017: Cardiology Research
https://www.readbyqxmd.com/read/28725292/-pre-metastatic-niches-in-breast-cancer-are-they-created-by-or-prior-to-the-tumour-onset-flammer-syndrome-relevance-to-address-the-question
#20
Rostyslav Bubnov, Jiri Polivka, Pavol Zubor, Katarzyna Konieczka, Olga Golubnitschaja
Breast cancer (BC) epidemic in the twenty-first century is characterised by around half a million deaths and 1.7 million new cases registered annually worldwide. Metastatic disease is the major cause of death in BC patient cohorts. Current statistics are much alarming from the viewpoint of the early mortality amongst BC patients with de novo metastatic disease. A new paradigm of so-called "pre-metastatic niches" may sufficiently promote our knowledge regarding potential pathomechanisms, individual predisposition and prognosis in development and progression of the metastatic disease...
June 2017: EPMA Journal
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