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Blood tests for heavy metals

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https://www.readbyqxmd.com/read/27916491/gene-expression-profiling-to-identify-the-toxicities-and-potentially-relevant-human-disease-outcomes-associated-with-environmental-heavy-metal-exposure
#1
Hesham M Korashy, Ibraheem M Attafi, Konrad S Famulski, Saleh A Bakheet, Mohammed M Hafez, Abdulaziz M S Alsaad, Abdul Rahman M Al-Ghadeer
Heavy metals are the most commonly encountered toxic substances that increase susceptibility to various diseases after prolonged exposure. We have previously shown that healthy volunteers living near a mining area had significant contamination with heavy metals associated with significant changes in the expression of some detoxifying genes, xenobiotic metabolizing enzymes, and DNA repair genes. However, alterations of most of the molecular target genes associated with diseases are still unknown. Thus, the aims of this study were to (a) evaluate the gene expression profile and (b) identify the toxicities and potentially relevant human disease outcomes associated with long-term human exposure to environmental heavy metals in mining area using microarray analysis...
December 1, 2016: Environmental Pollution
https://www.readbyqxmd.com/read/27891370/trace-elements-in-chronic-haemodialysis-patients-and-healthy-individuals-a-comparative-study
#2
Lokesh Shanmugam, Siva Ranganathan Green, Hemachandar Radhakrishnan, Tony Mathew Kadavanu, Arunkumar Ramachandrappa, Shashank Rakesh Tiwari, Amirtha Lakshmi Rajkumar, Ezhumalai Govindasamy
INTRODUCTION: End Stage Renal Disease (ESRD) patients despite receiving adequate Haemodialysis (HD) develop significant risk of Cardiovascular Disease (CVD). Abnormality in levels of trace elements may potentiate vascular injury by producing sustained inflammation and endothelial dysfunction. Hence, the present study was undertaken to evaluate the levels of trace elements in patients receiving HD. AIM: To study the blood levels of arsenic, cadmium, mercury, lead, chromium, barium, cobalt, caesium and selenium among ESRD patients undergoing HD and compare it with healthy individuals...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27888383/relationships-between-blood-mercury-levels-reproduction-and-return-rate-in-a-small-seabird
#3
Ingrid L Pollet, Marty L Leonard, Nelson J O'Driscoll, Neil M Burgess, Dave Shutler
Mercury (Hg) is a ubiquitous heavy metal that occurs naturally in the environment, but its levels have been supplemented for decades by a variety of human activities. Mercury can have serious deleterious effects on a variety of organisms, with top predators being particularly susceptible because methylmercury bioaccumulates and biomagnifies in food webs. Among birds, seabirds can have especially high levels of Hg contamination and Leach's storm-petrels (Oceanodroma leucorhoa), in particular, have amongst the highest known levels...
November 25, 2016: Ecotoxicology
https://www.readbyqxmd.com/read/27858271/pilot-study-on-the-internal-exposure-to-heavy-metals-of-informal-level-electronic-waste-workers-in-agbogbloshie-accra-ghana
#4
Jürgen Wittsiepe, Torsten Feldt, Holger Till, Gerd Burchard, Michael Wilhelm, Julius N Fobil
Informal-level electronic waste (e-waste)-processing activities are performed at hotspots in developing countries such as India, China, and Ghana. These activities increase the ambient burden of heavy metals and contribute to the toxic exposure of the general population. However, few data exist on the internal exposure of populations involved in these informal activities and in close contact with fumes from the direct combustion of electronic waste products in these countries. Therefore, in a cross-sectional study design, we analyzed blood, urine, and hair samples from 75 e-waste workers residing in and/or working on a large e-waste recycling site in Agbogbloshie, Accra, Ghana, and compared the results against those of 40 individuals living in a suburb of Accra without direct exposure to e-waste recycling activities...
November 17, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27770270/gadolinium-induced-effects-on-mammalian-cell-motility-adherence-and-chromatin-structure
#5
Gabor Nagy, Viktoria Baksa, Alexandra Kiss, Melinda Turani, Gaspar Banfalvi
The toxicity of gadolinium is reduced by chelating agents that render this heavy metal into contrast complexes used for medical magnetic resonance imaging. However, the dissociation of gadolinium chelates is known to generate Gd(3+) ions, the cellular toxicity of which has not been tested in details. The cytotoxic effects of Gd(III) ions were evaluated by monitoring the proliferation, measuring the cellular motility and following chromatin changes in various cell lines upon Gd(3+) treatment. Measurements applied long-term scanning microscopy and a perfusion platform that replaced the medium with test solutions, bypassed physical contact with the cell culture during experiments, and provided uninterrupted high time-resolution time-lapse photomicrography for an extended period of time...
October 22, 2016: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/27738246/is-mercury-in-tibetan-medicine-toxic-clinical-neurocognitive-and-biochemical-results-of-an-initial-cross-sectional-study
#6
Sarah Sallon, Yahav Dory, Yazeed Barghouti, Tsewang Tamdin, Rigzin Sangmo, Jamyang Tashi, Sonam Yangdon, Tenzin Yeshi, Tsetan Sadutshang, Michal Rotenburg, Elinor Cohen, Yehudit Harlavan, Galit Sharabi, Tali Bdolah-Abram
Mercury an important therapeutic substance in Tibetan Medicine undergoes complex "detoxification" prior to inclusion in multi-ingredient formulas. In an initial cross-sectional study, patients taking Tibetan Medicine for various conditions were evaluated for mercury toxicity. Two groups were identified: Group 1, patients taking " TSOTHEL: " the most important detoxified mercury preparation and Group 2, patients taking other mercury preparations or mercury free Tibetan Medicine. Atomic fluorescence spectrometry of Tibetan Medicine showed mercury consumption 130 µg/kg/day (Group 1) and 30 µg/kg/day (Group 2) (P ≤ 0...
October 13, 2016: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27708787/air-pollution-and-urinary-n-acetyl-b-glucosaminidase-levels-in-residents-living-near-a-cement-plant
#7
Min Soo Jung, Jae Yoon Kim, Hyun Seung Lee, Chul Gab Lee, Han Soo Song
BACKGROUND: To identify adverse renal effects due to air pollution derived from a cement plant in Korea. Urinary n-acetyl-B-glucosaminidase (U-NAG) levels in residents living near a cement plant were compared to those in a group who lived farther away from the plant. METHODS: From June to August 2013 and from August to November 2014, laboratory tests for U-NAG and heavy metal were conducted on 547 study participants. Based on the level of air pollution exposure, subjects were divided into the "less exposed group," (LEG) which consisted of 66 persons who lived more than 5 km away from the cement plant, the "more exposed group from the rural area" (MEG-R), which consisted of 272 persons, and the "more exposed group from downtown area" (MEG-D), which consisted of 209 persons who lived within a 1 km radius of the cement plant...
2016: Annals of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27687700/determine-multiple-elements-simultaneously-in-the-sera-of-umbilical-cord-blood-samples-a-very-simple-method
#8
Chunmei Liang, Zhijuan Li, Xun Xia, Qunan Wang, Ruiwen Tao, Yiran Tao, Haiyun Xiang, Shilu Tong, Fangbiao Tao
Analyzing the concentrations of heavy metals in the sera of umbilical cord blood samples can provide useful information about prenatal exposure to environmental agents. An analytical method based on ICP-MS to simultaneously determine multiple elements in umbilical cord blood samples was developed for assessing the in utero exposure to metallic and metalloid elements. The method only required as little as 100 μL of serum diluted 1:25 for direct analysis. Matrix-matched protocol was used to eliminate mass matrix interference and kinetic energy discrimination mode was used to eliminate the polyatomic ion interference...
September 30, 2016: Biological Trace Element Research
https://www.readbyqxmd.com/read/27670596/association-between-heavy-metal-exposure-and-poor-working-memory-and-possible-mediation-effect-of-antioxidant-defenses-during-aging
#9
Juliana Nery Souza-Talarico, Tania Marcourakis, Fernando Barbosa, Silvia Berlanga Moraes Barros, Diogo Pineda Rivelli, Sabine Pompéia, Paulo Caramelli, Pierrich Plusquellec, Sonia J Lupien, Raphael Fernandes Catucci, Andrea Regiani Alves, Deborah Suchecki
BACKGROUND: Inverse associations have been observed between memory performance and blood concentrations of cadmium (Cd) and lead (Pb). Low antioxidant cell activity has also been linked to decline in memory due to aging. However, it has not yet been established whether the heavy metal-memory relationship is mediated by differences in antioxidant activity. METHODS: We examined Cd and Pb levels, as well as oxidative stress parameters, in blood samples from 125 older adults (age range 50-82years)...
September 23, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27659349/blood-lead-concentrations-and-attention-deficit-hyperactivity-disorder-in-korean-children-a-hospital-based-case-control-study
#10
Jae Hong Park, Ju-Hee Seo, Young-Seoub Hong, Yu-Mi Kim, Je-Wook Kang, Jae-Ho Yoo, Hee Won Chueh, Jung Hyun Lee, Min Jung Kwak, Jeongseon Kim, Hae Dong Woo, Dong Woo Kim, Young Rong Bang, Byeong Moo Choe
BACKGROUND: Because the developing brain of a child is vulnerable to environmental toxins, even very low concentration of neurotoxin can affect children's neurodevelopment. Lead is a neurotoxic heavy metal which has the harmful effect on the striatal-frontal circuit of brain. This area of the brain is known to be closely related to attention deficit hyperactivity disorder (ADHD) pathophysiology. The primary objective of the present study was to investigate whether elevated blood lead concentration is a risk factor for ADHD...
September 22, 2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27457691/antidiabeticpotential-of-polyherbal-formulation-db14201-preclinical-development-safety-and-efficacy-studies
#11
Geetha Krishnan Gopalakrishna Pillai, Sonali S Bharate, Anshumali Awasthi, Ritu Verma, Gautam Mishra, Anu T Singh, Manu Jaggi, Ambrish Mithal, Ram A Vishwakarma
ETHNOPHARMACOLOGICAL RELEVANCE: The poly-herbal formulation DB14201 is a new combination of ayurvedic ingredients for treatment of diabetes. The aim of present study was to investigate safety and in vivo efficacy of DB14201 extract. Further this work was aimed to develop, characterize and standardize DB14201 extract and develop it as a botanical drug. MATERIALS AND METHODS: The polyherbal extract was standardized using four chemical markers. The LC-MS/MS method was developed for identification and quantification of mangiferin, berberine, kaempferol and curcumin...
July 22, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27406246/altered-urinary-porphyrins-and-mercury-exposure-as-biomarkers-for-autism-severity-in-egyptian-children-with-autism-spectrum-disorder
#12
Eman M Khaled, Nagwa A Meguid, Geir Bjørklund, Amr Gouda, Mohamed H Bahary, Adel Hashish, Nermin M Sallam, Salvatore Chirumbolo, Mona A El-Bana
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder that affects social, communication, and behavioral development. Recent evidence supported but also questioned the hypothetical role of compounds containing mercury (Hg) as contributors to the development of ASD. Specific alterations in the urinary excretion of porphyrin-containing ring catabolites have been associated with exposure to Hg in ASD patients. In the present study, the level of urinary porphyrins, as biomarkers of Hg toxicity in children with ASD, was evaluated, and its correlation with severity of the autistic behavior further explored...
December 2016: Metabolic Brain Disease
https://www.readbyqxmd.com/read/27335164/heavy-metal-mediated-innate-immune-responses-of-the-indian-green-frog-euphlyctis-hexadactylus-anura-ranidae-cellular-profiles-and-associated-th1-skewed-cytokine-response
#13
Uthpala A Jayawardena, Wanigasekara D Ratnasooriya, Deepthi D Wickramasinghe, Preethi V Udagama
Immune cell and cytokine profiles in relation to metal exposure though much studied in mammals has not been adequately investigated in amphibians, due mainly to lack of suitable reagents for cytokine profiling in non-model species. However, interspecies cross reactivity of cytokines permitted us to assay levels of IFNγ, TNFα, IL6 and IL10in a common anuran, the Indian green frog (Euphlyctis hexadactylus), exposed to heavy metals (Cd, Cr, Cu, Zn and Pb, at ~5ppm each) under field and laboratory settings in Sri Lanka...
October 1, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27262939/lethal-and-sub-lethal-effects-on-the-asian-common-toad-duttaphrynus-melanostictus-from-exposure-to-hexavalent-chromium
#14
Vindhya A K Fernando, Jagathpriya Weerasena, G Pemantha Lakraj, Inoka C Perera, Chandima D Dangalle, Shiroma Handunnetti, Sunil Premawansa, Mayuri R Wijesinghe
Chromium discharged in industrial effluents frequently occurs as an environmental pollutant, but the lethal and sub-lethal effects the heavy metal might cause in animals exposed to it have been insufficiently investigated. Selecting the amphibian Duttaphrynus melanostictus, we carried out laboratory tests to investigate the effects of short and long term exposure to hexavalent chromium (Cr(VI)) in both tadpoles and adult toads. The concentrations used were 0.002, 0.02, 0.2, 1.0 and 2.0mg/L, the first three corresponding to field levels...
August 2016: Aquatic Toxicology
https://www.readbyqxmd.com/read/27195142/long-term-exposure-of-lead-acetate-on-rabbit-renal-tissue
#15
Mohammad Hassan Karimfar, Afshar Bargahi, Darab Moshtaghi, Parviz Farzadinia
BACKGROUND: Lead has been widely used in different industries for ages. It is one of the heavy metals, highly poisonous even at low doses, and has biochemical, physiological and behavioral side effects on human and animals. It has been shown that lead has toxic effects on different tissues such as neural and genitourinary tissues, cardiovascular systems and blood. Therefore, high attention has been paid to its environmental pollutions. OBJECTIVES: Although many histological and biochemical studies have reported about the effects of lead on the renal tissue, there are a few studies about the ultrastructure and morphometric effects of lead on the kidney...
February 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/27190399/time-to-pregnancy-associated-with-couples-use-of-tobacco-products
#16
Katherine J Sapra, Dana B Barr, José M Maisog, Rajeshwari Sundaram, Germaine M Buck Louis
INTRODUCTION: Previous studies suggest female smoking increases time-to-pregnancy (TTP), a couple-dependent reproductive outcome, while associations with male smoking are more ambiguous. Furthermore, despite small increases in smokeless tobacco use in the United States, no prior study has evaluated TTP among smokeless tobacco users. METHODS: Using population-based sampling in 16 counties in Michigan and Texas, 501 couples discontinuing contraception to become pregnant were followed until positive pregnancy test or 12 months of trying...
November 2016: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/26925418/qualitative-chemical-analyses-of-ankaferd-hemostat-and-its-antioxidant-content-in-synthetic-gastric-fluids
#17
Ahmet Koluman, Nejat Akar, Umit Y Malkan, Ibrahim C Haznedaroglu
INTRODUCTION: Ankaferd hemostat (ABS) is the first topical haemostatic agent involving the red blood cell-fibrinogen interactions. The antihemorrhagic efficacy of ABS has been tested in controlled clinical trials. The drug induces the formation of an encapsulated complex protein web with vital erythroid aggregation. The aim of this study is to detect the essential toxicity profile and the antioxidant molecules inside ABS. METHODS: The pesticides were analyzed by GC-MS and LC-MS...
2016: BioMed Research International
https://www.readbyqxmd.com/read/26732378/is-there-a-relationship-between-tea-intake-and-maternal-whole-blood-heavy-metal-concentrations
#18
Cynthia K Colapinto, Tye E Arbuckle, Lise Dubois, William Fraser
The aim of this analysis was to examine the association between tea intake during pregnancy and maternal and infant metal exposures. Data from the Maternal-Infant Research on Environmental Chemicals (MIREC) Study, a pan-Canadian pregnancy cohort, were used. All participants with a gestational age of ⩾20 weeks (n=1954) with available biomarkers were included. Geometric means (GMs) for lead, arsenic, mercury, cadmium and manganese in maternal (first and third trimesters) and cord blood, as well as speciated arsenic in maternal urine in the first trimester, were calculated for participants who drank regular, green or herbal tea and for those who did not...
September 2016: Journal of Exposure Science & Environmental Epidemiology
https://www.readbyqxmd.com/read/26521060/screening-of-blood-levels-of-mercury-cadmium-and-copper-in-pregnant-women-in-dakahlia-egypt-new-attention-to-an-old-problem
#19
Shimaa M Motawei, Hossam E Gouda
Heavy metals toxicity is a prevalent health problem particularly in developing countries. Mercury and cadmium are toxic elements that have no physiologic functions in human body. They should not be present in the human body by any concentration. Copper, on the other hand, is one of the elements that are essential for normal cell functions and a deficiency as well as an excess of which can cause adverse health effects. To test blood levels of mercury, cadmium, and copper in pregnant women in Dakahlia, Egypt...
June 2016: Biological Trace Element Research
https://www.readbyqxmd.com/read/26357577/scombrotoxinism-protracted-illness-following-misdiagnosis-in-the-emergency-department
#20
Ghan-Shyam Lohiya, Sapna Lohiya, Sunita Lohiya, Vijay Krishna
Background. Scombrotoxinism is an acute toxin-induced illness caused primarily by bacterial synthesis of histamine in decomposed fish. Case Report. Immediately after taking 2-3 bites of cooked salmon, a clerical worker developed oral burning, urticaria, and asthma. In the emergency department, she was diagnosed with "allergies"; scombrotoxinism was never considered. She then developed wide-ranging symptoms (e.g., chronic fatigue, asthma, anxiety, multiple chemical sensitivity, and paresthesiae) and saw many specialists (in pulmonology, otorhinolaryngology, allergy, toxicology, neurology, psychology, and immunology)...
2015: Case Reports in Emergency Medicine
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