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https://www.readbyqxmd.com/read/29034097/the-association-between-cadmium-and-lead-exposure-and-blood-pressure-among-workers-of-a-smelting-industry-a-cross-sectional-study
#1
Hyun Chan An, Joo Hyun Sung, Jiho Lee, Chang Sun Sim, Sang Hoon Kim, Yangho Kim
BACKGROUND: Lead and cadmium are harmful heavy metals that are used for a variety of occupational purposes. Considering their potentially hazardous effects on health, studies on the association between exposure to these two heavy metals and health disorders have been actively conducted. This study aimed to determine the association between blood lead and cadmium levels and blood pressure in workers exposed to lead and cadmium in a smelter. METHODS: Nine hundred and sixty-three male workers who worked in a smelter, and underwent medical examinations at the Ulsan University Hospital between January 1 and December 31, 2014, were selected as participants...
2017: Annals of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29029324/cadmium-exposure-impairs-cognition-and-olfactory-memory-in-male-c57bl-6-mice
#2
Hao Wang, Liang Zhang, Glen M Abel, Daniel R Storm, Zhengui Xia
Cadmium (Cd) is a heavy metal of high interest to the Superfund Initiative. Recent epidemiology studies have suggested a possible association between Cd exposure and cognitive as well as olfactory impairments in humans. However, studies in animal models are needed to establish a direct causal relationship between Cd exposure and impairments in cognition and olfaction. This study aims to investigate the toxic effect of Cd on cognition and olfactory function in mice. One group of 8-week old C57BL/6 male mice was exposed to 3 mg/L Cd (in the form of CdCl2) through drinking water for 20 weeks for behavior tests and final blood Cd concentration analysis...
September 25, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28974026/joint-toxicity-of-different-heavy-metal-mixtures-after-a-short-term-oral-repeated-administration-in-rats
#3
Hong Su, Zhou Li, Samuel Selorm Fiati Kenston, Hongbo Shi, Yafei Wang, Xin Song, Yuanliang Gu, Tabatha Barber, Joni Aldinger, Baobo Zou, Min Ding, Jinshun Zhao, Xialu Lin
The systemic toxicity of different combinations of heavy metal mixtures (HMMs) was studied according to equivalent proportions of the eight most common detectable heavy metals found in fish consumption in the Ningbo area of China. The ion mass proportions of Zn, Cu, Mn, Cr, Ni, Cd, Pb, and Hg were 1070.0, 312.6, 173.1, 82.6, 30.0, 13.3, 6.6, and 1.0, respectively. In this study, 10 experimental groups were set as follows: M8 (Pb + Cd + Hg + Ni + Cu + Zn + Mn + Cr); M5 (Pb + Cd + Hg + Ni + Cr); M4A (Pb + Cd + Hg + Ni); M4B (Cu + Zn + Mn + Cr); M3 (Cu + Zn + Mn); Cr; Cu; Zn; Mn; and control...
October 1, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28971261/studies-on-acute-and-chronic-toxicity-of-cadmium-to-freshwater-snail-lymnaea-acuminata-lamarck-with-special-reference-to-behavioral-and-hematological-changes
#4
Kishore Dhara, Nimai Chandra Saha, Arpan Kumar Maiti
Molluscs have long been regarded as promising bioindicator and biomonitoring subjects for heavy metals as molluscs are highly tolerant to heavy metals and exhibit high accumulation in their body. In spite of several previous studies about the impact of cadmium on molluscs, little information exists in literatures concerning the toxic effects of cadmium on Lymnaea acuminata, especially pertaining to behavioral and hematological changes as these are considered effective bioindicators and biomonitoring variables for detecting heavy metals in polluted water bodies...
October 2, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28920782/evaluation-of-lead-and-mercury-prevalence-in-bald-eagles-haliaeetus-leucocephalus-from-the-mid-atlantic-united-states
#5
Andreas Eleftheriou, Lisa Murphy, Sallie Welte
Heavy metal contamination of the environment remains a critical issue. Lead and mercury exposure, particularly, can affect avian health. Bald eagles (Haliaeetus leucocephalus) ingest these metals through their diets. Lead and mercury prevalence were examined in bald eagles from three mid-Atlantic US states between 2004 and 2013. Blood samples were analyzed using atomic absorption spectrometry. Wilcoxon score tests were used to detect differences in lead and mercury over time. Counties of origin for birds with clinically significant metal levels were identified...
September 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28829631/in-vitro-evaluation-of-damage-by-heavy-metals-in-tight-and-gap-junctions-of-sertoli-cells
#6
Juan Ramos-Treviño, Susana Bassol-Mayagoitia, Pablo Ruiz-Flores, Perla Karina Espino-Silva, Odila Saucedo-Cárdenas, Sheila Adela Villa-Cedillo, Martha P Nava-Hernández
The Sertoli cell plays a vital role during the spermatogenesis process and has been identified as one of the main targets of the toxic action of heavy metals on the seminiferous epithelium. In the present work, the effect of lead (Pb), Arsenic (As), and Cadmium (Cd) in primary cultures of Sertoli cells was analyzed by measuring the expression of the genes Cldn11, Ocln, and Gja1 that participate in the tight and gap junctions, which are responsible for maintaining the blood-testis barrier. Sertoli cells were isolated from the testes of Wistar rats...
August 22, 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/28827971/the-potency-of-red-seaweed-eucheuma-cottonii-extracts-as-hepatoprotector-on-lead-acetate-induced-hepatotoxicity-in-mice
#7
Giftania Wardani, Nuraini Farida, Rina Andayani, Mahmiah Kuntoro, Sri Agus Sudjarwo
BACKGROUND: Lead is one of the most toxic metals, producing severe organ damage in animals and humans. Oxidative stress is reported to play an important role in lead acetate-induced liver injury. AIM: This study was carried out to investigate the role of ethanol extract of Eucheuma cottonii in protecting against lead acetate-induced hepatotoxicity in male mice. MATERIALS AND METHODS: The sample used fifty male mice which were divided into five groups: negative control (mice were given daily with Aquadest); positive control (mice were given daily with lead acetate 20 mg/kg body weight (BW) orally once in a day for 21 days); and the treatment group (mice were given E...
July 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28802093/clinical-aspects-of-opium-adulterated-with-lead-in-iran-a-review
#8
REVIEW
Samira Alinejad, Jan Aaseth, Mohammad Abdollahi, Hossein Hassanian-Moghaddam, Omid Mehrpour
Adulteration of drugs with poisonous substances during production or consumption has caused numerous health problems. Among contaminants that have the potential of producing poisonous effects are the heavy metals lead, arsenic and thallium that make up an important group of toxic substances. The emergence of these new health problems related to opioid abuse has precipitated this MiniReview on the status of the most hazardous and common opioid adulterants. In fact, adulterated opium is a major public health problem and can threaten the health of users...
August 12, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28734265/decreased-lung-function-with-mediation-of-blood-parameters-linked-to-e-waste-lead-and-cadmium-exposure-in-preschool-children
#9
Xiang Zeng, Xijin Xu, H Marike Boezen, Judith M Vonk, Weidong Wu, Xia Huo
Blood lead (Pb) and cadmium (Cd) levels have been associated with lower lung function in adults and smokers, but whether this also holds for children from electronic waste (e-waste) recycling areas is still unknown. To investigate the contribution of blood heavy metals and lung function levels, and the relationship among living area, the blood parameter levels, and the lung function levels, a total of 206 preschool children from Guiyu (exposed area), and Haojiang and Xiashan (reference areas) were recruited and required to undergo blood tests and lung function tests during the study period...
November 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28667913/lead-and-cadmium-exposure-higher-thyroid-antibodies-and-thyroid-dysfunction-in-chinese-women
#10
Xiaomin Nie, Yi Chen, Yingchao Chen, Chi Chen, Bing Han, Qin Li, Chunfang Zhu, Fangzhen Xia, Hualing Zhai, Ningjian Wang, Yingli Lu
BACKGROUND: Exposure to lead(Pb) or cadmium(Cd) has been related to decreasing thyroxine in many previous studies. The underlying mechanisms have not been clarified. Heavy metal-induced thyroid autoimmunity in pregnant women has been found, despite having been rarely explored in the general population. OBJECTIVES: We aimed to determine whether the blood levels of lead(BPb) or cadmium(BCd) related to the levels of sera antibodies to thyroid proteins and thyroid dysfunction in the general population...
November 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28484633/predictors-and-immunological-correlates-of-sublethal-mercury-exposure-in-vampire-bats
#11
Daniel J Becker, Matthew M Chumchal, Alexandra B Bentz, Steven G Platt, Gábor Á Czirják, Thomas R Rainwater, Sonia Altizer, Daniel G Streicker
Mercury (Hg) is a pervasive heavy metal that often enters the environment from anthropogenic sources such as gold mining and agriculture. Chronic exposure to Hg can impair immune function, reducing the ability of animals to resist or recover from infections. How Hg influences immunity and susceptibility remains unknown for bats, which appear immunologically distinct from other mammals and are reservoir hosts of many pathogens of importance to human and animal health. We here quantify total Hg (THg) in hair collected from common vampire bats (Desmodus rotundus), which feed on blood and are the main reservoir hosts of rabies virus in Latin America...
April 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28236523/acute-but-not-chronic-exposure-to-arsenic-provokes-glucose-intolerance-in-rats-possible-roles-for-oxidative-stress-and-the-adrenergic-pathway
#12
Mohsen Rezaei, Mohammd Javad Khodayar, Enayatollah Seydi, Alboghobeish Soheila, Isa Kazemzadeh Parsi
OBJECTIVES: Health problems due to heavy metals have become a worldwide concern. Along with its carcinogenicity, arsenic exposure results in impairment of glucose metabolism and insulin secretion as well as altered gene expression and signal transduction. However, the exact mechanism behind the behaviour of arsenic on glucose homeostasis and insulin secretion has not yet been fully understood. METHODS: Fasting blood sugar and glucose tolerance tests were evaluated...
February 21, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28223206/accumulation-of-heavy-metals-in-people-on-a-gluten-free-diet
#13
Stephanie L Raehsler, Rok Seon Choung, Eric V Marietta, Joseph A Murray
BACKGROUND & AIMS: Specific foods such as fish and rice have high concentrations of metals such as arsenic, mercury, lead, cadmium, and cobalt. Many gluten-free diets (GFDs) include these foods, so we evaluated whether a GFD was associated with increased metal bioaccumulation. METHODS: We performed a population-based, cross-sectional study using data collected from the National Health and Nutrition Examination Survey (NHANES), from 2009 through 2012, collecting information on the diagnosis of celiac disease and adherence to a GFD...
February 20, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28195859/metallosis-identified-via-intraoperative-cell-salvage-a-case-report
#14
Lauren M Parker, Mark H Yazer, Jonathan H Waters
Intraoperative cell salvage, whereby shed surgical blood is recovered for autologous reinfusion, is frequently used during hip arthroplasty because of the potential for significant blood loss. The following cases describe 2 instances in which chromium and cobalt particles from patients' metal-on-metal hip implants were identified within the blood recovery system. Results of heavy metal testing during the second case suggest that the use of a leukocyte reduction filter effectively reduces metal concentrations to below normal circulating levels...
February 15, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/28063411/the-properties-of-red-seaweed-kappaphycus-alvarezii-and-its-effect-on-mammary-carcinogenesis
#15
Vi-Sion Chang, Patrick N Okechukwu, Swee-Sen Teo
The edible red seaweed (Kappaphycus alvarezii) is one of the algae species which was found to be rich in nutrients and nutraceutical. Hence, K. alvarezii may have the ability to suppress cancer through its antiproliferative properties. The aim of this study was to investigate the potential compounds of K. alvarezii, cytotoxicity properties of K. alvarezii extract on breast cancer cell line (MCF-7), investigated toxicity effect of high dosage K. alvarezii extract in rats and determined the effect of K. alvarezii on 7, 12-dimethylbenz[a]anthracene (DMBA) mammary carcinogenesis in rats...
March 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27989277/unnecessary-investigations-in-environmental-medicine
#16
Annette Greiner, Hans Drexler
BACKGROUND: Patients in environmental medicine often want a thorough diagnostic evaluation of nonspecific symptoms. Unconventional testing, as well as conventional testing for indications other than the established ones, can lead to false diagnoses and, in turn, to substantial emotional, social, and financial harm. The goal of this single-center study was to assess inappropriate diagnostic testing among the patients of a specialized university outpatient clinic for environmental medicine...
November 18, 2016: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/27977422/metallosis-identified-via-intraoperative-cell-salvage
#17
Lauren M Parker, Mark H Yazer, Jonathan H Waters
Intraoperative cell salvage, whereby shed surgical blood is recovered for autologous reinfusion, is frequently used during hip arthroplasty because of the potential for significant blood loss. The following cases describe 2 instances in which chromium and cobalt particles from patients' metal-on-metal hip implants were identified within the blood recovery system. Results of heavy metal testing during the second case suggest that the use of a leukocyte reduction filter effectively reduces metal concentrations to below normal circulating levels...
December 12, 2016: A & A Case Reports
https://www.readbyqxmd.com/read/27916491/gene-expression-profiling-to-identify-the-toxicities-and-potentially-relevant-human-disease-outcomes-associated-with-environmental-heavy-metal-exposure
#18
Hesham M Korashy, Ibraheem M Attafi, Konrad S Famulski, Saleh A Bakheet, Mohammed M Hafez, Abdulaziz M S Alsaad, Abdul Rahman M Al-Ghadeer
Heavy metals are the most commonly encountered toxic substances that increase susceptibility to various diseases after prolonged exposure. We have previously shown that healthy volunteers living near a mining area had significant contamination with heavy metals associated with significant changes in the expression of some detoxifying genes, xenobiotic metabolizing enzymes, and DNA repair genes. However, alterations of most of the molecular target genes associated with diseases are still unknown. Thus, the aims of this study were to (a) evaluate the gene expression profile and (b) identify the toxicities and potentially relevant human disease outcomes associated with long-term human exposure to environmental heavy metals in mining area using microarray analysis...
February 2017: Environmental Pollution
https://www.readbyqxmd.com/read/27891370/trace-elements-in-chronic-haemodialysis-patients-and-healthy-individuals-a-comparative-study
#19
Lokesh Shanmugam, Siva Ranganathan Green, Hemachandar Radhakrishnan, Tony Mathew Kadavanu, Arunkumar Ramachandrappa, Shashank Rakesh Tiwari, Amirtha Lakshmi Rajkumar, Ezhumalai Govindasamy
INTRODUCTION: End Stage Renal Disease (ESRD) patients despite receiving adequate Haemodialysis (HD) develop significant risk of Cardiovascular Disease (CVD). Abnormality in levels of trace elements may potentiate vascular injury by producing sustained inflammation and endothelial dysfunction. Hence, the present study was undertaken to evaluate the levels of trace elements in patients receiving HD. AIM: To study the blood levels of arsenic, cadmium, mercury, lead, chromium, barium, cobalt, caesium and selenium among ESRD patients undergoing HD and compare it with healthy individuals...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27888383/relationships-between-blood-mercury-levels-reproduction-and-return-rate-in-a-small-seabird
#20
Ingrid L Pollet, Marty L Leonard, Nelson J O'Driscoll, Neil M Burgess, Dave Shutler
Mercury (Hg) is a ubiquitous heavy metal that occurs naturally in the environment, but its levels have been supplemented for decades by a variety of human activities. Mercury can have serious deleterious effects on a variety of organisms, with top predators being particularly susceptible because methylmercury bioaccumulates and biomagnifies in food webs. Among birds, seabirds can have especially high levels of Hg contamination and Leach's storm-petrels (Oceanodroma leucorhoa), in particular, have amongst the highest known levels...
January 2017: Ecotoxicology
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