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Cytokine gene polymorphism

Poulami Majumder, Keheibamding Thou, Mandar Bhattacharya, Vineet Nair, Sujay Ghosh, Subrata Kumar Dey
Periodontitis is a very common inflammatory oral disease. Tumor necrosis factor α (TNF-α), a cytokine has been involved with the gingival tissue destruction and remodeling occurrence. We aimed at investigation of the association of single nucleotide polymorphisms (SNPs) in TNF-α gene promoter region to the susceptibility of aggressive and chronic periodontitis in eastern Indian population. A total of 397 DNA samples from venous blood have been isolated, among them 40 individuals were aggressive periodontitis patient, 157 were identified chronic periodontitis patients and remaining 200 were healthy individuals...
February 15, 2018: Bioscience Reports
Elisavet Stavropoulou, Gratiela G Pircalabioru, Eugenia Bezirtzoglou
Cytochromes are expressed in many different tissues of the human body. They are found mostly in intestinal and hepatic tissues. Cytochromes P450 (CYPs) are enzymes that oxidize substances using iron and are able to metabolize a large variety of xenobiotic substances. CYP enzymes are linked to a wide array of reactions including and O-dealkylation, S-oxidation, epoxidation, and hydroxylation. The activity of the typical P450 cytochrome is influenced by a variety of factors, such as genus, environment, disease state, herbicide, alcohol, and herbal medications...
2018: Frontiers in Immunology
Kavita Shalia, Dhananjaya Saranath, Jaipreet Rayar, Vinod K Shah, Manoj R Mashru, Surendra L Soneji
Background & objectives: Acute myocardial infarction (AMI) is a major health concern in India. The aim of the study was to identify single nucleotide polymorphisms (SNPs) associated with AMI in patients using dedicated chip and validating the identified SNPs on custom-designed chips using high-throughput microarray analysis. Methods: In pilot phase, 48 AMI patients and 48 healthy controls were screened for SNPs using human CVD55K BeadChip with 48,472 SNP probes on Illumina high-throughput microarray platform...
October 2017: Indian Journal of Medical Research
Maja Živković, Ivana Kolić, Snežana Jesić, Ana Jotić, Aleksandra Stanković
Objectives: Chronic otitis media (COM) is followed by irreversible tissue damage and destruction of the middle ear structures, with the possibility of complications under the maintenance of inflammation. Inflammatory mediators such as cytokines play a crucial role in the initial stage of inflammation. The aim of this study was to evaluate the association of the polymorphisms in two innate immunity/inflammation cascade genes from interleukin-1 (IL-1) gene cluster with COM with regard to cholesteatoma...
February 14, 2018: Clinical and Experimental Otorhinolaryngology
C A Naranjo-Galvis, A de-la-Torre, L E Mantilla-Muriel, L Beltrán-Angarita, X Elcoroaristizabal-Martín, R McLeod, N Alliey-Rodriguez, I J Begeman, C López de Mesa, J E Gómez-Marín, J C Sepúlveda-Arias
Toxoplasmosis is caused by infection with the protozoan parasite Toxoplasma gondii which has the capacity to infect all warm-blooded animals worldwide. Toxoplasmosis is a major cause of visual defects in the Colombian population, however, the association between genetic polymorphisms in cytokine genes and susceptibility to ocular toxoplasmosis has not been studied in this population. This work evaluates the associations between polymorphisms in genes coding for cytokines TNF-α (rs1799964, rs1800629, rs1799724, rs1800630, rs361525); IL-1β (rs16944, rs1143634, rs1143627), IL-1α (rs1800587); IFN-γ (rs2430561); IL-10 (rs1800896, rs1800871), and the presence of ocular toxoplasmosis (OT) in a sample of Colombian population (61 patients with OT and 116 healthy controls)...
February 5, 2018: Infection and Immunity
Edith Elena Uresti-Rivera, Rocío Edith García-Jacobo, José Alfredo Méndez-Cabañas, Laura Elizabeth Gaytan-Medina, Nancy Cortez-Espinosa, Diana Patricia Portales-Pérez, Roberto González-Amaro, José Antonio Enciso-Moreno, Mariana Haydee García-Hernández
It has been reported that an increased function of the P2X7 purinergic receptor is associated with an increase in both insulin sensitivity and secretion. Accordingly, we explored the possible effect of the 1068 G>A polymorphism of the gene P2RX7 on glucose homeostasis and the levels of the anti-inflammatory cytokine IL-1Ra in T2D patients. The presence of the 1068 G>A polymorphism in T2D patients (n = 100) and healthy subjects (n = 100) was determined by DNA sequencing, and serum levels of IL-1Ra were measured by ELISA...
February 6, 2018: Gene
Ada A Sandoval-Carrillo, Cosme Alvarado-Esquivel, Carlos Salas-Martinez, Edna M Mendez-Hernandez, Antonio Sifuentes-Alvarez, Ana L Martínez-Martinez, Juan M Castillo-Orona, Jesus Hernandez-Tinoco, Elizabeth I Antuna-Salcido, Luis F Sanchez-Anguiano, Lilia M Velez Velez, Sergio M Salas-Pacheco, Francisco X Castellanos-Juarez, Osmel La Llave-Leon, Oscar Arias-Carrion, Jose M Salas-Pacheco
BACKGROUND: Depressive disorders are common during pregnancy. Actually, there is compelling evidence that the inflammatory response system is important in the pathophysiology of depression. Higher concentrations of proinflammatory cytokines including TNF-α in depressed subjects has been described. Because several polymorphisms in the TNF-α promoter region are known to affect its gene expression, the aim of this study was determine whether TNF-α -857C/T, -308G/A, and -238G/A polymorphisms confer susceptibility to depression during pregnancy in a Mexican mestizo population...
February 7, 2018: CNS & Neurological Disorders Drug Targets
Aysun Coşkun Keşoğlu, Canan Bural, Gonca Erköse Genç, Zayre Erturan, Çiğdem Çınar, Fatma Oğuz, Tayfun Bilgin, Hakan Bilhan
OBJECTIVE: This clinical study investigated the association between cytokine gene polymorphism and Candida growth in DS patients. SUBJECTS AND METHODS: Saliva and blood samples of 160 complete denture wearers (80 healthy controls and 80 with DS) were collected for mycological and gene polymorphism testing, respectively. Salivary Candida growth and TNF-α, TGF-β, IL-6 and IL-10 genotypes were investigated. Data were analyzed using Student t-test, Mann-Whitney U, Chi-square analysis and Continuity (yates) correction tests (p<...
February 9, 2018: Oral Diseases
Jeanette E Boudreau, Katharine C Hsu
Natural killer (NK) cells maintain immune homeostasis by detecting and eliminating damaged cells. Simultaneous activating and inhibitory input are integrated by NK cells, with the net signal prompting cytotoxicity and cytokine production, or inhibition. Chief among the inhibitory ligands for NK cells are 'self' human leukocyte antigen (HLA) molecules, which are sensed by killer immunoglobulin-like receptors (KIR). Through a process called 'education', the functional capabilities of each NK cell are counterbalanced by their sensitivity for inhibition by co-inherited 'self' HLA...
January 27, 2018: Current Opinion in Immunology
Sibel Özdaş, Talih Özdaş
Nasal polyps (NP) are the most common pathological change that occurs in the nasal mucosa and is characterized by mucosal inflammation. Although its etiology and pathogenesis have not been clearly explained, its pathophysiology is arranged by the balance between pro-inflammatory and anti-inflammatory cytokines. The Secretoglobin 1C1 gene synthesizes odor molecule binding proteins (OBPs) in the nasal mucosa and regulates some cytokines. The Secretoglobin 1C1 gene expression could be disrupted by polymorphisms that may act as a possible cause of a disruption in the regulation of the promotor of the gene...
January 31, 2018: Cellular and Molecular Biology
Lavanya Joshi, Lakshmi Kiran Chelluri, Vijayalakshmi Valluri, Sumanlatha Gaddam
Single nucleotide polymorphisms (SNPs) of cytokine genes have been found to be involved in the clinical outcome of Tuberculosis. The present study was aimed to identify the high risk genotypes in Tuberculosis patients and their household contacts. A total of 490 subjects were studied which includes 150 active pulmonary tuberculosis patients (APTB), 190 household contacts (HHC) and 150 healthy controls (HC). The SNPs of TNF-α (-308A/G), IL-10(-1082G/A) and IL-6(-174G/C) were performed by ARMs PCR. The IL-10 GA genotype showed significant association in APTB and HHC and was 2...
February 2018: Comparative Immunology, Microbiology and Infectious Diseases
Dar-In Tai, Wen-Juei Jeng, Chun-Yen Lin
Genome-wide association studies have indicated that human leukocyte antigen (HLA)-DP and HLA-DQ play roles in persistent hepatitis B virus (HBV) infection in Asia. To understand the evolution of HBV-related single nucleotide polymorphisms (SNPs) and to correlate these SNPs with chronic HBV infection among different populations, we conducted a global perspective study on hepatitis-related SNPs. We selected 12 HBV-related SNPs on the HLA locus and two HBV and three hepatitis C virus immune-related SNPs for analysis...
December 2017: Hepatology Communications
Vadim Mitrokhin, Alexey Nikitin, Olga Brovkina, Dmitry Khodyrev, Alexander Zotov, Nikita Vachrushev, Dmitry Dragunov, Andrey Shim, Mitko Mladenov, Andre Kamkin
Purpose: The present study investigated the influence of IL-18/18R genetic variants on cytokine expression in patients with stable coronary artery disease (CAD). Materials and methods: The polymorphisms rs1946518, rs187238, rs326, rs1169288, and rs183130 were determined in patients with and without CAD. Circulating cytokine levels were measured immunologically. Results: The rs1946518-GG genotype shows higher IL-18 concentration in the group with CAD, but still not significant...
2018: Journal of Inflammation Research
Onur İsmi, Cengiz Özcan, Gürbüz Polat, Seval Kul, Kemal Görür, Tuğçe Pütürgeli
Objective: Nasal Polyp (NP) is a benign mass of the paranasal sinuses that protrudes into the nasal cavity. The exact underlying pathogenesis is not known. In this study we aimed to determine the genetic susceptibility of NP formation in relation to TNF-α-308 and IL-1β-511 promoter region gene polymorphisms. Methods: A total of 71 patients with NP with asthma (n=21) or without asthma (n=50) were taken as the study group, and 91 healthy volunteers were taken as the control group...
June 2017: Turkish Archives of Otorhinolaryngology
Maya Gulubova, Elina Aleksandrova, Tatyana Vlaykova
INTRODUCTION: Anti-inflammatory cytokines such as interleukine-10 (IL-10) and the transforming growth factor beta-1 (TGF-®1) have a complex role in the development of colorectal cancer (CRC). Dendritic cells (DCs) are the cellular component of the inflammatory microenvironment in the tumor and infiltration of tumors by DCs is associated with better prognosis and fewer metastases. AIMS: In the current study we aimed to explore the role of two single nucleotide polymorphisms (SNPs) in the promoter regions of TGFB1 and IL10 genes and their associations with infiltrating DCs in CRC...
January 31, 2018: Journal of Gene Medicine
Yuzhu Xu, Hongxu Wu, Xiaojie Wu, Yongjian Xu, Jianping Zhao, Jungang Xie, Jun Yu
Glucocorticoids are the primary anti-inflammatory therapy for asthma, but their effects are characterized by some interindividual variability that might have a genetic basis.We aimed to determine the relationship between pulmonary function change and the variant of the glucocorticoid-induced transcript 1 (GLCCI1) gene in patients with asthma receiving long-term ICS treatment, the association of GLCCI1 genotypes and the level of GLCCI1 expression and cytokines production.A total of 418 patients with asthma, including 25 individuals from 11 families with a history of asthma, were enrolled...
December 2017: Medicine (Baltimore)
Caixiao Jiang, Xinyan Ma, Shunxiang Qi, Guangyue Han, Yan Li, Yanfang Liu, Lanfen Liu
BACKGROUND: Tumor necrosis factor-alpha (TNF-α) is an important cytokine and has been reported to be associated with the pathogenesis of many autoimmune and inflammatory diseases. TNF-α gene is located on a region that has been found to be associated with obsessive-compulsive disorder (OCD). We performed this meta-analysis to assess the relationship between susceptibility to OCD and the TNF-α-238G/A gene polymorphism. METHODS: An extensive search of the available literature on the association between the susceptibility to OCD and the TNF gene polymorphism was conducted by searching PubMed, Web of Knowledge, Embase, Chinese Web of Knowledge, Wanfang, and Chongqing VIP database...
February 2018: Medicine (Baltimore)
N Akhtar, K K Verma, A Sharma
Parthenium dermatitis is a chronic immuno-inflammatory, distressing skin disease and is mediated by activated T-lymphocyte which is primarily manifested on the exposed sites of the face, neck, hand and flexures. Parthenium hysterophorus is ubiquitous, hence it is diffi-cult to avoid the aero-allergenic antigen parthenin, responsible for the contact dermatitis. The pathogenesis of parthenium dermatitis is characterized by infiltration of T-lymphocytes into challenged skin sites and the development of a cutaneous inflammation due to altered regulatory network of pro and anti-inflammatory cytokines...
November 27, 2017: European Annals of Allergy and Clinical Immunology
Valentin P Volobaev, Aleksey V Larionov, Ekaterina E Kalyuzhnaya, Ekaterina S Serdyukova, Svetlana Yakovleva, Vladimir G Druzhinin, Olga O Babich, Elena G Hill, Victor A Semenihin, Nikolay I Panev, Varvara I Minina, Saravana Devi Sivanesan, Pravin Naoghare, Juliana da Silva, Gustavo R M Barcelos, Alexander Y Prosekov
Anthracosilicosis (AS), a prevalent form of pneumoconiosis among coal miners, results from the accumulation of carbon and silica in the lungs from inhaled coal dust. This study investigated genotoxic effects and certain cytokine genes polymorphic variants in Russian coal miners with АS. Peripheral leukocytes were sampled from 129 patients with AS confirmed by X-ray and tissue biopsy and from 164 asymptomatic coal miners. Four single-nucleotide polymorphisms were genotyped in the extracted DNA samples: IL1β T-511C (rs16944), IL6 C-174G (rs1800795), IL12b A1188C (rs3212227) and VEGFA C634G (rs2010963)...
January 25, 2018: Mutagenesis
Efren Avendaño-Tamayo, Omer Campo, Juan Camilo Chacón-Duque, Ruth Ramírez, Winston Rojas, Piedad Agudelo-Flórez, Gabriel Bedoya, Berta Nelly Restrepo
INTRODUCTION: The genetic makeup of the host contributes to the clinical profile of dengue. This could be due to the effect of variants in the genes encoding pro-inflammatory cytokines. OBJECTIVE: To evaluate the association between the variants of three polymorphisms in TNFA, IL6 and IFNG candidate genes with dengue severity in a sample of Colombian population. MATERIALS AND METHODS: We evaluated the rs1800750, rs2069843, and rs2069705 polymorphisms in TNFA, IL6 and IFNG candidate genes, respectively, in 226 patients with dengue infection...
December 1, 2017: Biomédica: Revista del Instituto Nacional de Salud
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