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Cytokine gene polymorphism

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https://www.readbyqxmd.com/read/29053126/-effect-of-cytokine-genes-and-season-of-birth-on-personality
#1
M V Alfimova, V E Golimbet, G I Korovaitseva, T V Lezheiko, N V Kondrat'ev, M V Gabaeva
AIM: To evaluate the interaction effects of season of birth and immune system genes on the personality traits 'Novelty seeking' (NS) and 'Self-directedness' (SD). Based on results on an influence of the immune system on the brain processes, the authors hypothesized that the interaction of immune system genes and season of birth, which is relevant for immune phenotype, can contribute to the development of personality traits. MATERIAL AND METHODS: NS and SD were measured in 336 healthy volunteers, aged from 16 to 67 years, using the Temperament and Character Inventory (TCI-125)...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29047186/il-1rn-gene-polymorphisms-were-associated-with-breast-cancer-risk-in-a-chinese-han-population
#2
Tianbo Jin, Wei Cao, Xiaoxiao Zuo, Miao Li, Ya Yang, Tiansong Liang, Hongyao Yang, Xinhan Zhao, Daoke Yang
BACKGROUND: Interleukin (IL) is a large family of endogenous cytokine which are crucial in the regulation of inflammation and immunological responses. IL-1 receptor antagonist (IL-1RN) has been found to be associated with risk breast cancer (BC) in Korean and Indian women. However, little information is found about the polymorphisms of IL-1RN in Chinese Han BC patient. METHODS: We investigated the association between single-nucleotide polymorphisms (SNPs) in IL-1RN and BC risk in a case-control study that included 530 BC cases and 628 healthy controls...
October 18, 2017: Journal of Gene Medicine
https://www.readbyqxmd.com/read/29042807/association-between-interleukin-6-6r-gene-polymorphisms-and-coronary-artery-disease-in-russian-population-influence-of-interleukin-6-6r-gene-polymorphisms-on-inflammatory-markers
#3
Vadim Mitrokhin, Alexey Nikitin, Olga Brovkina, Dmitry Khodyrev, Alexander Zotov, Nikita Vachrushev, Dmitry Dragunov, Andrey Shim, Mitko Mladenov, Andre Kamkin
This study determined the genotype effects of interleukin (IL)-6/IL-6R single nucleotide polymorphisms (SNPs) on circulating levels of different cytokines in healthy and coronary artery disease (CAD) patients with different allele frequencies. In the control patients, rs1800795 showed significant differences in IL-18 concentrations between CC and CG and CC and GG genotypes (P=0.003 and 0.004, respectively). Furthermore, circulatory IL-1β was significantly different between GC and GG genotypes from the same SNP (P=0...
2017: Journal of Inflammation Research
https://www.readbyqxmd.com/read/29042282/increased-levels-of-circulating-tnf-%C3%AE-is-associated-with-308g-a-promoter-polymorphism-of-tnf-%C3%AE-gene-in-diabetic-nephropathy
#4
Dhamodharan Umapathy, Krishnamoorthy Ezhilarasi, Vairamani Mariappanadar, Vijay Viswanathan, Kunka Mohanram Ramkumar
The crucial role of Tumor Necrosis Factor-α (TNF-α) on renal function in patients with Diabetic Nephropathy (DN) has been well documented. The present study was designed to investigate the association of TNF-α [-308G/A, (rs1800629)] single nucleotide polymorphism (SNP) on the susceptibility to DN subjects and to correlate it with the plasma levels of TNF-α along with circulatory TNF-α receptor super family cytokines (sTNFR-1 and sTNFR-2). A total of 756 subjects, were recruited and divided into groups [Group-I, Controls (n=218), Group-II, Normoalbuminuria (n=196), Group-IIIa, Microalbuminuria (n=178), Group-IIIb, Macroalbuminuria (n=164)] and were genotyped by PCR-restriction fragment length polymorphism (RFLP)...
October 14, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29041889/-multifactorial-prognostication-of-remote-outcomes-in-patients-with-non-st-elevation-acute-coronary-syndrome
#5
V O Tsygankova, G N Lozhkina, H M Khasanova, D A Kuimov, I Y Ragino, N V Maksimov, I M Voevoda
AIM: Creation of a mathematical nonlinear regression model for prognostication of 1 year outcomes after non-ST elevation acute coronary syndrome (NSTE ACS) for optimization of rehabilitation, secondary prevention, and personalized approach to treatment. MATERIAL AND METHODS: We included in this study 135 patients with confirmed NSTE ACS (mean age 59.1±6.1 years, 94 men and 41 women) admitted to hospital No 1 in Novosibirsk during 2010. During hospitalization and 1 year after discharge these patients received standard medical therapy...
August 2017: Kardiologiia
https://www.readbyqxmd.com/read/29041886/-polymorphisms-in-genes-of-cytokines-and-matrix-metalloproteinases-associated-with-ischemic-heart-disease-in-patients-with-type-2-diabetes
#6
V V Klimontov, V A Shevchenko, M D Bulumbaeva, F V Prokof 'ev, I V Konenkov
OBJECTIVE: To examine associations between ischemic heart disease (IHD) and polymorphisms in cytokine genes (IL-1B, IL-4, IL-6, IL-10, TNFA, VEGF) and matrix metalloproteinase genes (MMP2, MMP3, MMP9) in patients with type 2 diabetes. MATERIAL AND METHODS: We studied 232 Caucasian diabetic subjects (33 men and 199 women aged 50-70 years). In 93 patients IHD was verified by treadmill test and/or coronary angiography (86 subjects with stable angina, 19 with previous myocardial infarction)...
August 2017: Kardiologiia
https://www.readbyqxmd.com/read/29034996/interleukin-1%C3%AE-polymorphism-and-serum-level-are-associated-with-pediatric-asthma
#7
Paulina Sobkowiak, Irena Wojsyk-Banaszak, Maja Kowalewska, Eliza Wasilewska, Wojciech Langwiński, Zdzisława Kycler, Maria Skibińska, Anna Bręborowicz, Ewa Jassem, Aleksandra Szczepankiewicz
BACKGROUND AND AIM: Interleukin-1 is a pro-inflammatory cytokine found in two forms (α and β). The α form is mainly cell-bound, whereas IL-1β is primarily secreted by macrophages in response to immune system stimulation. We hypothesized that polymorphic variants of interleukin 1 genes may play a role in childhood asthma risk. The aim of this study was to investigate if IL-1α and β polymorphism is associated with asthma in a pediatric population and if the genotype affects its serum level...
October 16, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29033934/ebi3-prevents-trypanosoma-cruzi-induced-myocarditis-by-dampening-ifn-%C3%AE-driven-inflammation
#8
Tiago Silva Medina, Gabriela Gonçalves Oliveira, Maria Cláudia Silva, Bruna Araújo David, Grace Kelly Silva, Denise Morais Fonseca, Renata Sesti-Costa, Amanda Farage Frade, Monique Andrade Baron, Barbara Ianni, Alexandre Costa Pereira, Christophe Chevillard, Edécio Cunha-Neto, José Antonio Marin-Neto, João Santana Silva
The identification of anti-inflammatory mediators can reveal important targetable molecules capable of counterbalancing Trypanosoma cruzi-induced myocarditis. Composed of Ebi3 and IL-27p28 subunits, IL-27 is produced by myeloid cells and is able to suppress inflammation by inducing IL-10-producing Tr1 cells, thus emerging as a potential candidate to ameliorate cardiac inflammation induced by T. cruzi. Although IL-27 has been extensively characterized as a suppressive cytokine that prevents liver immunopathogenesis after T...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29027627/association-of-tnf-%C3%AE-3959t-c-gene-polymorphisms-in-the-chinese-population-with-intracranial-aneurysms
#9
Juntao Hu, Jie Luo, Hui Wang, Chaojia Wang, Xiaodong Sun, Anrong Li, Yi Zhou, Yuhang Liu, Qianxue Chen
Recent studies have demonstrated that cytokines play an important role in the pathogenesis of intracranial aneurysm (IA). Tumor necrosis factor-α (TNF-α) is an important proinflammatory cytokine, which was shown to influence the development of IA, but there is no research data from China. Hence, the purpose of this study was to explore the relationship between TNF-α polymorphisms and IA in China. The association of genetic variants of TNF-α gene expression was investigated in a Chinese population with IA...
October 13, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29023858/interleukin-1-gene-cluster-haplotype-analysis-in-the-chronic-outcome-prediction-of-the-hepatitis-b-virus-infection
#10
Bita Javan, Mohamad Reza Kalani, Majid Shahbazi
Hepatitis B virus (HBV) infection is well known as an important cause of the chronic liver disease. The screening of the genotype of certain cytokines might be helpful to predict the clinical outcome of an HBV infection. The present study investigates the relationship between the polymorphism and haplotypes of the Interleukin-1 (IL-1) gene family, including IL-1-alpha (IL-1A), IL-1-beta (IL-1B) and IL-1 receptor antagonist (IL-1RN), with chronic HBV infection. 297 chronic HBV and 333 matched on sex and age control individuals were genotyped using the standard sequence-specific- polymerase chain reaction primer (SSP-PCR) method...
October 11, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/29020887/the-potential-association-of-tumor-necrosis-factor-%C3%AE-eta-252-g-a-cytokine-gene-polymorphism-with-immune-thrombocytopenic-purpura-among-egyptian-children
#11
Dalia Saber Morgan, Rasha Abdel-RaoufAbdel-Aziz Afifi, Shereen Mohamed El-Hoseiny, Dalia Gamil Amin, Sara Yahia Gaber Ibrahim
OBJECTIVES: The main objective of this study was to study tumor necrosis factor beta (TNFB) + 252G/A gene polymorphism, known to be related to autoimmunity, in immune thrombocytopenia (ITP) patients. We also aimed to investigate the association between TNFB + 252G/A polymorphism and susceptibility to develop persistent/chronic ITP. METHODS: One hundred pediatric ITP patients, as well as 50 age- and sex-matched healthy Egyptian subjects, were included. Genotyping of TNF-β gene (G252A) was done using the PCR-RFLP method...
October 12, 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/29017513/association-between-tnf-il1b-il6-il10-and-ifng-polymorphisms-and-recurrent-miscarriage-a-case-control-study
#12
Jianting Ma, Xingguang Zhang, Gang He, Chunlin Yang
BACKGROUND: Approximately half of recurrent miscarriages have unexplained etiology. Recent evidences suggest that cytokines are important determinants in pregnancy maintenance and as such, cytokine gene polymorphisms, which can affect cytokine production and/or functionality, could play a role in the disorder. Thus, we aimed to investigate the association of selected cytokine gene polymorphisms with risk of recurrent miscarriage among Chinese. METHODS: TNF -238G > A, TNF -308G > A, IL1B -511 T > C, IL1B 3954C > T, IL6 -174G > C, IL6 -634C > G, IL10 -1082A > G and IFNG 874A > T polymorphisms were genotyped on 775 women with idiopathic recurrent miscarriage and 805 healthy parous control women...
October 10, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28993831/association-of-snps-haplotypes-in-promoter-of-tnf-a-and-il-10-gene-together-with-life-style-factors-in-prostate-cancer-progression-in-indian-population
#13
Kapil Bandil, Pallavi Singhal, Atika Dogra, Sudhir K Rawal, D C Doval, Anil K Varshney, Mausumi Bharadwaj
OBJECTIVE: Levels of proinflammatory (TNF A) and anti-inflammatory (IL-10) cytokines play a key role in the progression of inflammation as well as cancer disease. We were investigating the potential association of single-nucleotide polymorphisms (SNPs)/haplotypes in proinflammatory (TNF A) and anti-inflammatory (IL-10) cytokines locus with the development of PCa in Indian population. MATERIALS AND METHODS: We had genotyped 235 BPH/PCa samples (130 BPH and 105 cancer) along with 115 control samples for proinflammatory (TNF A -238G/A and -308G/A) and anti-inflammatory (IL-10 -1082A/G, -819C/T and -592C/A) cytokines SNPs in the gene promoter region using ARMS-PCR method...
October 9, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/28990887/il-1%C3%AE-polymorphism-in-copd-patients-in-turkish-population
#14
Onur Baykara, Nuriye Banu Tömekçe Taşkıran, Şadan Soyyiğit, Nur Buyru
Introduction: Chronic obstructive pulmonary disease (COPD) is a common respiratory condition characterized by persistent airflow limitation and is associated with an enhanced chronic inflammatory response in the airways and the lung to noxious particles or gases. Interleukin-1 beta (IL-1β) is a major pro-inflammatory cytokine expressed by many cells such as macrophages, neutrophils and monocytes and functions in cellular activities such as proliferation, differentiation and apoptosis...
June 2017: Tüberküloz Ve Toraks
https://www.readbyqxmd.com/read/28987962/association-of-cytokine-gene-polymorphisms-with-the-complications-of-allogeneic-haematopoietic-stem-cell-transplantation
#15
Anna Dukat-Mazurek, Maria Bieniaszewska, Andrzej Hellmann, Grażyna Moszkowska, Piotr Trzonkowski
The purpose of our study was to confirm the prevalence of the association between single nucleotide polymorphisms present in genes encoding cytokines and the complications occurring after haematopoietic stem cell transplantation (HSCT). 108 recipients and 81 donors were typed for TNF-α (-308), TGF-β1 (codon 10,25), IL-10 (-1082,-819,-592), IL-6 (-174) and INF-γ (+874). Our studies have shown a tendency toward association between the occurrence of acute form of graft versus host disease (aGVHD) and IL-6 genotype...
October 4, 2017: Human Immunology
https://www.readbyqxmd.com/read/28987807/canine-susceptibility-to-visceral-leishmaniasis-a-systematic-review-upon-genetic-aspects-considering-breed-factors-and-immunological-concepts
#16
Tassia Cristina Bello de Vasconcelos, Marina Carvalho Furtado, Vínicus Silva Belo, Fernanda Nazaré Morgado, Fabiano Borges Figueiredo
Dogs have different susceptibility degrees to leishmaniasis; however, genetic research on this theme is scarce, manly on visceral form. The aims of this systematic review were to describe and discuss the existing scientific findings on genetic susceptibility to canine leishmaniasis, as well as to show the gaps of the existing knowledge. Twelve articles were selected, including breed immunological studies, genome wide associations or other gene polymorphism or gene sequencing studies, and transcription approaches...
October 5, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28984602/modulation-of-immune-responses-to%C3%A2-herpes-simplex-virus-type%C3%A2-1-by-ifnl3-and-irf7-polymorphisms-a%C3%A2-study-in%C3%A2-alzheimer-s-disease
#17
Andrea Saul Costa, Simone Agostini, Franca Rosa Guerini, Roberta Mancuso, Milena Zanzottera, Enrico Ripamonti, Vittorio Racca, Raffaello Nemni, Mario Clerici
Herpes simplex virus type 1 (HSV-1) has long been suspected to play a role in Alzheimer's disease (AD), the most common form of dementia. IFN-lambda (IFN-λ) is one of the key cytokine in innate antiviral defenses and, in particular, has an appreciable antiviral activity against HSV-1 infection. IFN-λ expression is regulated by the interaction between two different proteins: Mediator Complex 23 (MED23) and Interferon-Responsive Transcription Factor 7 (IRF7); single nucleotide polymorphisms (SNPs) in these genes as well as in IFNL3 were shown to be differently distributed in AD patients...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28980933/predictive-role-of-cytokines-il-10-il-12-and-tnf-%C3%AE-gene-polymorphisms-for-the-development-of-osteonecrosis-of-the-femoral-head-in-the-chinese-han-population
#18
L Yuan, W Li, Z B Tian, Y Li, S Sun
The progressive neurodegenerative process in osteonecrosis of the femoral head (ONFH) is accompanied by chronic inflammation, including activation of microglia and astrocytes that express pro-inflammatory cytokines. Up to now, numerous studies of genetic epidemiology have assessed the association of anti- and pro-inflammation cytokines gene polymorphisms and risk of ONFH in different populations, but contradictory results were obtained due to the genetic heterogeneity of in different populations. In the study, 250 ONFH patients and 228 matched healthy controls from Shandong Province were recruited to evaluate the influence of interleukin-10 (IL-10) rs1800872, IL-12 rs3212227 and tumor necrosis factor-(TNF-α) rs1800629 polymorphism in ONFH...
September 30, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28977146/alzheimer-s-disease-and-cytokine-il-10-gene-polymorphisms-is-there-an-association
#19
Carolina Antunes Magalhães, Maria das Graças Carvalho, Lirlândia Pires de Sousa, Paulo Caramelli, Karina Braga Gomes
Alzheimer's disease (AD) is the most common form of dementia. In the last 15 years, a new theory has proposed the autoimmune mechanism as a trigger for AD. Studies on the association between AD and inflammatory biomarkers have yielded controversial results. Interleukin-10 (IL-10), an anti-inflammatory mediator, has been pointed out as one of the main cytokines associated with the occurrence of AD. Moreover, treatment that increases IL-10 levels could be a potential therapy for AD, since this cytokine acts on amyloid and pro-inflammatory molecule reduction...
September 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/28968968/predictive-single-nucleotide-polymorphism-markers-for-acute-oral-mucositis-in-patients-with-nasopharyngeal-carcinoma-treated-with-radiotherapy
#20
Ziyu Le, Xiaoshuang Niu, Ying Chen, Xiaomin Ou, Guoqi Zhao, Qi Liu, Wenzhi Tu, Chaosu Hu, Lin Kong, Yong Liu
The aim of this study was to investigate the association between the susceptibility of severe oral mucositis (OM) in Chinese nasopharyngeal carcinoma (NPC) patients treated with radiotherapy and single nucleotide polymorphisms (SNPs) across the whole genome. SNPs were screened in a total of 24 patients with NPC and an additional 6 were subjected to mRNA expression analysis. Patients were subdivided into CTC 0-2 (CTC toxicity grade 0, 1, and 2) and CTC 3+ (CTC toxicity grade 3 and above) groups according to their CTC (common toxicity criteria) scores...
September 8, 2017: Oncotarget
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