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https://www.readbyqxmd.com/read/28429079/the-r2r3-myb-tt2b-and-the-bhlh-tt8-genes-are-the-major-regulators-of-proanthocyanidin-biosynthesis-in-the-leaves-of-lotus-species
#1
Francisco José Escaray, Valentina Passeri, Ana Perea-García, Cristian Javier Antonelli, Francesco Damiani, Oscar Adolfo Ruiz, Francesco Paolocci
By exploiting interspecific hybrids and their progeny, we identified key regulatory and transporter genes intimately related to proanthocyanidin biosynthesis in leaves of Lotus spp. Proanthocyanidins (PAs), known as condensed tannins, are polymeric flavonoids enriching forage legumes of key nutritional value to prevent bloating in ruminant animals. Unfortunately, major forage legumes such as alfalfa and clovers lack PAs in edible tissues. Therefore, engineering the PA trait in herbage of forage legumes is paramount to improve both ecological and economical sustainability of cattle production system...
April 20, 2017: Planta
https://www.readbyqxmd.com/read/28413522/electroacupuncture-combined-with-mosapride-alleviates-symptoms-in-diabetic-patients-with-gastroparesis
#2
Wenping Pan, Zhankui Wang, Feilong Tian, Mingxian Yan, Yan Lu
The present study compared the clinical effectiveness of electroacupuncture (EA), monotherapy and combination therapy involving the administration of EA and mosapride in diabetic patients with severe or mild symptoms suggestive of gastroparesis. A total of 56 patients with type 2 diabetes who had symptoms suggestive of gastroparesis for >3 months were divided into two groups according to the Gastroparesis Cardinal Symptom Index (GCSI) score, including 33 in the mild group (GCSI score <3.5) and 23 in the severe group (GCSI score ≥3...
April 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28411456/urinary-bladder-injury-during-cesarean-delivery-maternal-outcome-from-a-contemporary-large-case-series
#3
Lina Salman, Shachar Aharony, Anat Shmueli, Arnon Wiznitzer, Rony Chen, Rinat Gabbay-Benziv
BACKGROUND: Urinary bladder injury is a rare complication during cesarean delivery. Little is known on maternal outcome following this injury. OBJECTIVE: To evaluate short and long-term maternal outcome following bladder injury during cesarean delivery. STUDY DESIGN: A retrospective case series of all pregnancies complicated by full-thickness bladder injury during cesarean delivery in a single university affiliated tertiary medical center (August 2007-June 2016)...
April 5, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28408004/development-of-the-diary-for-irritable-bowel-syndrome-symptoms-to-assess-treatment-benefit-in-clinical-trials-foundational-qualitative-research
#4
MULTICENTER STUDY
Sheri E Fehnel, Claire M Ervin, Robyn T Carson, Gianna Rigoni, Jeffrey M Lackner, Stephen Joel Coons
BACKGROUND: Irritable bowel syndrome (IBS) is a chronic gastrointestinal disorder characterized by abdominal pain and alterations in bowel habits. Three subtypes are defined on the basis of stool patterns: diarrhea-predominant IBS, constipation-predominant IBS, and alternating or mixed IBS. OBJECTIVES: To develop patient-reported outcome measures for qualification by the Food and Drug Administration to support product approvals and labeling in IBS; the article focuses on the qualitative research that provided the foundation for the new measures...
April 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28403981/management-of-the-multiple-symptoms-of-irritable-bowel-syndrome
#5
REVIEW
Magnus Simrén, Hans Törnblom, Olafur S Palsson, William E Whitehead
Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders. A stepwise management approach is advocated for patients with IBS. For a substantial proportion of patients with mild symptoms, general management principles, including making a confident diagnosis and offering explanation, reassurance, and dietary and lifestyle advice, are sufficient. However, many patients continue to have moderate-to-severe symptoms and are not satisfied solely with this approach. In these patients, use of pharmacotherapy on the basis of the predominant symptom (constipation, diarrhoea, pain, or bloating) or combination of symptoms is the next step...
February 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28377793/the-plastid-genomes-of-nonphotosynthetic-algae-are-not-so-small-after-all
#6
COMMENT
Francisco Figueroa-Martinez, Aurora M Nedelcu, Adrian Reyes-Prieto, David R Smith
The thing about plastid genomes in nonphotosynthetic plants and algae is that they are usually very small and highly compact. This is not surprising: a heterotrophic existence means that genes for photosynthesis can be easily discarded. But the loss of photosynthesis cannot explain why the plastomes of heterotrophs are so often depauperate in noncoding DNA. If plastid genomes from photosynthetic taxa can span the gamut of compactness, why can't those of nonphotosynthetic species? Well, recently we showed that they can...
2017: Communicative & Integrative Biology
https://www.readbyqxmd.com/read/28347550/unexpected-obstetric-haemorrhage-krukenberg-tumour
#7
J Montoro García, M Cabellos Olivares, A Cabana Navia, J López Saña, J R Rodríguez Fraile
Obstetric haemorrhage can endanger the lives of mother and foetus. It often occurs unexpectedly without clear predictors. A high degree of suspicion helps to avoid delaying resuscitation measures. We present the case of a ruptured ovarian metastasis that occurred during labour. It caused a massive bleed forcing a caesarean section due to non-reassuring foetal status. This was an unprecedented and undescribed onset of Krukenberg tumour formation. Malignant tumours in pregnancy are rare and difficult to diagnose due to their clinical manifestations which often overlap with those of pregnancy itself (dyspepsia, nausea and bloating)...
March 24, 2017: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/28344797/poor-reproducibility-of-breath-hydrogen-testing-implications-for-its-application-in-functional-bowel-disorders
#8
Chu K Yao, Caroline J Tuck, Jacqueline S Barrett, Kim Ek Canale, Hamish L Philpott, Peter R Gibson
BACKGROUND: Limited data are available regarding the reproducibility of lactulose and fructose breath testing for clinical application in functional bowel disorders. OBJECTIVES: The purpose of this study was to investigate the reproducibility of lactulose and fructose breath hydrogen testing and assess symptom response to fructose testing. METHODS: Results were analysed from 21 patients with functional bowel disorder with lactulose breath tests and 30 with fructose breath tests who completed another test >2 weeks later...
March 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28343108/the-effects-of-modified-versus-unmodified-wheat-gluten-administration-in-patients-with-celiac-disease
#9
Mariacatia Marino, Rossella Casale, Raffaele Borghini, Sara Di Nardi, Giuseppe Donato, Antonio Angeloni, Salvatore Moscaritolo, Lorenza Grasso, Giuseppe Mazzarella, Marco Di Tola, Mauro Rossi, Antonio Picarelli
Celiac disease (CD) treatment requires a gluten-free diet (GFD), although alternative approaches have been proposed. Modification of gliadin peptides using microbial transglutaminase (mTG) inhibits their ability to induce immune response in vitro. Our aim was to evaluate the safety of mTG-modified wheat flour ingestion in CD patients. Twenty-one CD patients in remission were randomized to receive mTG-modified (n=11) or unmodified (n=10) wheat flour rusks, in double-blind fashion. Monthly, patients completed a symptom questionnaire...
March 23, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28339544/laxatives-do-not-improve-symptoms-of-opioid-induced-constipation-results-of-a-patient-survey
#10
Anton Emmanuel, Martin Johnson, Paula McSkimming, Sara Dickerson
Introduction.:  Laxatives are commonly used to treat opioid-induced constipation, the commonest and most bothersome complication of opioids. However, laxatives have a nonspecific action and do not target underlying mechanisms of opioid-induced constipation; their use is associated with abdominal symptoms that negatively impact quality of life. Objective.:  To assess the effects of laxatives in patients taking opioids for chronic pain. Methods...
October 8, 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28336106/nomogram-for-predicting-oral-feeding-intolerance-in-patients-with-acute-pancreatitis
#11
Melody G Bevan, Varsha M Asrani, Sayali A Pendharkar, Rachel L Goodger, John A Windsor, Maxim S Petrov
OBJECTIVES: Oral feeding intolerance (OFI) is a common complication of acute pancreatitis that leads to prolonged hospitalization, increased use of hospital resources, and impaired quality of life. However, there are no clinically useful predictors of OFI. The aims of this study were to determine whether gastrointestinal dysmotility is associated with the development of OFI, and whether the gastroparesis cardinal symptom index (GCSI) can be used as a predictive tool in a clinical setting...
April 2017: Nutrition
https://www.readbyqxmd.com/read/28332032/qualitative-assessment-of-the-symptoms-and-impact-of-pancreatic-exocrine-insufficiency-pei-to-inform-the-development-of-a-patient-reported-outcome-pro-instrument
#12
Colin D Johnson, Rob Arbuckle, Nicola Bonner, Gary Connett, Enrique Dominguez-Munoz, Philippe Levy, Doris Staab, Nicola Williamson, Markus M Lerch
BACKGROUND: Pancreatic exocrine insufficiency (PEI) affects patients with chronic pancreatitis (CP) and cystic fibrosis (CF) who produce insufficient digestive pancreatic enzymes. Common symptoms include steatorrhoea, diarrhea, and abdominal pain. OBJECTIVE: The objective of the study was to develop and test the content validity of a patient-reported outcome (PRO) instrument assessing PEI symptoms and their impact on health-related quality of life. METHODS: Instrument development was supported by a literature review, expert physician interviews (n = 10: Germany 4, UK 3, France 3), and exploratory, qualitative, concept-elicitation interviews with patients with CF and CP with PEI (n = 61: UK 29, Germany 18, France 14) and expert physicians (n = 10)...
March 22, 2017: Patient
https://www.readbyqxmd.com/read/28323273/hydrogen-and-methane-based-breath-testing-in-gastrointestinal-disorders-the-north-american-consensus
#13
Ali Rezaie, Michelle Buresi, Anthony Lembo, Henry Lin, Richard McCallum, Satish Rao, Max Schmulson, Miguel Valdovinos, Salam Zakko, Mark Pimentel
OBJECTIVES: Breath tests (BTs) are important for the diagnosis of carbohydrate maldigestion syndromes and small intestinal bacterial overgrowth (SIBO). However, standardization is lacking regarding indications for testing, test methodology and interpretation of results. A consensus meeting of experts was convened to develop guidelines for clinicians and research. METHODS: Pre-meeting survey questions encompassing five domains; indications, preparation, performance, interpretation of results, and knowledge gaps, were sent to 17 clinician-scientists, and 10 attended a live meeting...
March 21, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28321329/utility-of-the-wireless-motility-capsule-and-lactulose-breath-testing-in-the-evaluation-of-patients-with-parkinson-s-disease-who-present-with-functional-gastrointestinal-symptoms
#14
Andrew Su, Rita Gandhy, Carrolee Barlow, George Triadafilopoulos
BACKGROUND: The aetiology and origin of gastrointestinal symptoms in Parkinson's disease (PD) remains poorly understood. Gastroparesis, small bowel transit delay and bacterial overgrowth may, individually or collectively, play a role. AIMS: In patients with PD and functional gastrointestinal symptoms, we aimed to determine the utility of the wireless motility capsule and lactulose breath tests in further defining their symptoms' aetiology. METHODS: In this retrospective cohort study, consecutive patients with PD and functional gastrointestinal symptoms underwent clinical assessment, as well as wireless motility capsule and lactulose breath testing using standard protocols...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/28318702/antibiotic-associated-diarrhea-clinical-characteristics-and-the-presence-of-clostridium-difficile
#15
A Rodríguez-Varón, O M Muñoz, J Pulido-Arenas, S B Amado, M Tobón-Trujillo
INTRODUCTION AND AIMS: Evidence in Colombia and Latin America has been insufficient for establishing the clinical characteristics of patients with antibiotic-associated diarrhea (AAD). The present study attempts to describe the clinical characteristics of patients with AAD and to determine the presence of Clostridium difficile, utilizing the polymerase chain reaction (PCR) technique. MATERIALS AND METHODS: Forty-three patients with AAD, managed at the Hospital Universitario San Ignacio in Bogotá, Colombia, were evaluated...
March 18, 2017: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/28318414/the-prevalence-of-self-reported-premenstrual-symptoms-and-evaluation-of-regular-exercise-with-premenstrual-symptoms-among-female-employees-in-taiwan
#16
Su-Ying Tsai, Fu-Chen Kuo, Hsin-Chih Kuo, Li-Ling Liao
Few studies have focused on premenstrual symptoms in employees. This study explored the prevalence of premenstrual symptoms in 7,193 female employees aged 18-55 years in a large electronics manufacturer in Taiwan from August 2014 to December 2014 and examined whether regular exercise was associated with premenstrual symptoms. Information was collected on demographics, lifestyle, menstrual history, menstrual pain, and premenstrual symptoms. Half of the participants reported irregular menstruation; 79.4% reported a moderate menstruation amount, and half reported little impact of menstrual pain at work...
March 20, 2017: Women & Health
https://www.readbyqxmd.com/read/28317316/severely-impaired-gastric-accommodation-is-a-hallmark-of-post-nissen-functional-dyspepsia-symptoms
#17
A Pauwels, V Boecxstaens, C Broers, J F Tack
BACKGROUND: Laparoscopic Nissen fundoplication is a commonly performed antireflux surgery, after which reflux symptoms are well controlled, however, complications such as inability to belch or dyspeptic symptoms (mimicking those of functional dyspepsia [FD]) might occur. The aim of the study was to prospectively evaluate symptom pattern and underlying pathophysiological mechanisms in patients with post-Nissen dyspepsia. METHODS: Twenty-four patients (12 f, mean age 44...
March 20, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28316762/mesalazine-has-no-effect-on-mucosal-immune-biomarkers-in-patients-with-diarrhea-dominant-irritable-bowel-syndrome-referred-to-shariati-hospital-a-randomized-double-blind-placebo-controlled-trial
#18
Mohammad Reza Ghadir, Mehri Poradineh, Masoud Sotodeh, Reza Ansari, Shadi Kolahdoozan, Ahmad Hormati, Mohammad Hosein Yousefi, Samaneh Mirzaei, Homayoon Vahedi
BACKGROUND Intestinal mast cells may cause gastrointestinal symptoms in patients with diarrhea-dominant irritable bowel syndrome (IBS). The objective of this study was to determine the effect of mesalazine on the number of lamina propria mast cells and clinical manifestations of patients with diarrhea-dominant IBS referred to Shariati Hospital affiliated to Tehran University of Medical Sciences. METHODS This was a randomized placebo-controlled double-blind trial conducted on 49 patients with diarrhea-dominant IBS...
January 2017: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28315875/systematic-review-of-exocrine-pancreatic-insufficiency-after-gastrectomy-for-cancer
#19
Jennifer Straatman, Jim Wiegel, Nicole van der Wielen, E P Jansma, Miguel A Cuesta, Donald L van der Peet
BACKGROUND: Survival rates after a total gastrectomy with adequate lymphadenectomy are improving, leading to a shift in outcomes of interest from survival to postoperative outcomes and symptoms. In this systematic review, we investigate gastrointestinal symptoms that occur after a gastrectomy in relation to exocrine pancreatic insufficiency and the effect of pancreatic exocrine enzyme supplementation on these symptoms. METHODS: Online databases PubMed, Embase, and Cochrane Library were systematically searched in accordance with the PRISMA guidelines...
March 18, 2017: Digestive Surgery
https://www.readbyqxmd.com/read/28315177/physical-symptoms-screening-for-cardiopulmonary-complications-of-obesity-using-audio-computer-assisted-self-interviews
#20
Jorge L Morales-Estrella, Farah D Ciftci, William E Trick, Keiki Hinami
PURPOSE: The main study objective was to assess the predictive value of selected physical symptoms for screening obstructive sleep apnea and major cardiac conditions in adults with obesity, thus providing the evidence for routine symptom screening of obesity complications endorsed by obesity management clinical practice guidelines. METHODS: We performed a retrospective cohort study using patient-reported outcomes data including the physical symptoms severity component of the Memorial Symptom Assessment Scale administered through Audio Computer-Assisted Self-Interviews combined with data from the electronic medical records of an urban safety-net primary care clinic...
March 17, 2017: Quality of Life Research
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