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JOURNAL ARTICLE
Timmie A Britton, Chenggang Wu, Yi-Wei Chen, Dana Franklin, Yimin Chen, Martha I Camacho, Truc T Luong, Asis Das, Hung Ton-That
This paper illuminates the significant question of how the oral commensal Fusobacterium nucleatum adapts to the metabolically changing environments of several extra-oral sites such as placenta and colon to promote various diseases as an opportunistic pathogen. We demonstrate here that the highly conserved <u>R</u>hodobacter <u>n</u>itrogen-<u>f</u>ixation complex, commonly known as Rnf complex, is key to fusobacterial metabolic adaptation and virulence. Genetic disruption of this Rnf complex causes global defects in polymicrobial interaction, biofilm formation, cell growth and morphology, hydrogen sulfide production, and ATP synthesis...
December 7, 2023: MBio
#22
EDITORIAL
Timmy Frawley, Blánaid Gavin, Charlotte Valeur, Karen Van Morin
No abstract text is available yet for this article.
November 27, 2023: Journal of Clinical Nursing
#23
JOURNAL ARTICLE
Kelly J Dew-Budd, Hiu Tung Chow, Timmy Kendall, Brandon C David, James A Rozelle, Rebecca A Mosher, Mark A Beilstein
In plants, de novo DNA methylation is guided by 24-nt short interfering (si)RNAs in a process called RNA-directed DNA methylation (RdDM). Primarily targeted at transposons, RdDM causes transcriptional silencing and can indirectly influence expression of neighboring genes. During reproduction, a small number of siRNA loci are dramatically upregulated in the maternally-derived seed coat, suggesting that RdDM might have a special function during reproduction. However, the developmental consequence of RdDM has been difficult to dissect because disruption of RdDM does not result in overt phenotypes in Arabidopsis (Arabidopsis thaliana), where the pathway has been most thoroughly studied...
November 21, 2023: Plant Physiology
#24
JOURNAL ARTICLE
Timmy Lindgren, Josefine Westdahl, Sigrid Stjernswärd, Erika A Saliba-Gustafsson, Lena Flyckt, Nitya Jayaram-Lindström, Joachim Eckerström
Patient-initiated brief admission (PIBA) allows patients to decide when admission to psychiatric care is necessary. This may prevent long-term hospitalisation and promote patient participation. Research on psychiatric nurses' experiences with PIBA is lacking, therefore 11 nurses were interviewed and data analysed using content analysis. Prominent categories were: improved personal development for the patient, more equal nurse-patient relationship, rapid access to a safe environment and strengthened professional collaboration...
November 20, 2023: Issues in Mental Health Nursing
#25
JOURNAL ARTICLE
Uday Yanamandra, Alka Khadwal, Setu Gupta, Timmy Thomas, Deepesh Lad, Neelam Taneja, Gaurav Prakash, Neelam Varma, Subhash Varma, Pankaj Malhotra
BACKGROUND: Diarrhea is the major cause of discomfort and morbidity of patients undergoing hematopoietic stem cell transplant (HSCT). The cause of diarrhea may be infective or non-infective. METHODS: This is a prospective single center observational study from North India conducted over a period of approximately 4 years among 105 patients who underwent HSCT (autologous-72, allogeneic-33). The objective of the study was to identify the overall incidence and characteristics of diarrhea in HSCT in the real world, to evaluate any differences among allogeneic or autologous transplants, incidence of C Difficile among diarrheal patients, and antimicrobial usage among these patients...
2023: Medical Journal, Armed Forces India
#26
JOURNAL ARTICLE
Fiona Pui Yee Tsui, Stanley Sau Ching Wong, Timmy Chi Wing Chan, Yvonne Lee, Chi Wai Cheung
OBJECTIVE: The study tests the reliability and validity of the Cantonese Chinese version of Short Form McGill Pain Questionnaire 2 (SF-MPQ-2-CC). METHODS: The original Short Form McGill Pain Questionnaire (SF-MPQ-2) was translated into Cantonese Chinese version. Cantonese-speaking chronic pain patients from three pain centers in Hong Kong were recruited and asked to complete SF-MPQ-2-CC, validated Chinese versions of Identification Pain questionnaire (ID Pain), Pain Catastrophizing Scale (PCS), and Short Form Health Survey (SF-36) for evaluation of convergent and divergent validity, 2 weeks apart for evaluation of internal consistency...
November 17, 2023: Pain Practice: the Official Journal of World Institute of Pain
#27
JOURNAL ARTICLE
Leigh C Carmody, Michael A Gargano, Sabrina Toro, Nicole A Vasilevsky, Margaret P Adam, Hannah Blau, Lauren E Chan, David Gomez-Andres, Rita Horvath, Megan L Kraus, Markus S Ladewig, David Lewis-Smith, Hanns Lochmüller, Nicolas A Matentzoglu, Monica C Munoz-Torres, Catharina Schuetz, Berthold Seitz, Morgan N Similuk, Teresa N Sparks, Timmy Strauss, Emilia M Swietlik, Rachel Thompson, Xingmin Aaron Zhang, Christopher J Mungall, Melissa A Haendel, Peter N Robinson
BACKGROUND: Navigating the clinical literature to determine the optimal clinical management for rare diseases presents significant challenges. We introduce the Medical Action Ontology (MAxO), an ontology specifically designed to organize medical procedures, therapies, and interventions. METHODS: MAxO incorporates logical structures that link MAxO terms to numerous other ontologies within the OBO Foundry. Term development involves a blend of manual and semi-automated processes...
November 9, 2023: Med
#28
REVIEW
Adam Timmis, Dzianis Kazakiewicz, Aleksandra Torbica, Nick Townsend, Radu Huculeci, Victor Aboyans, Panos Vardas
Variations in cardiovascular disease (CVD) burden between West and South European countries are rarely reported. To address this knowledge gap, The Lancet Regional Health-Europe convened experts from a broad range of countries to assess the current state of knowledge of cardiovascular disease inequalities across Europe. This Review is specifically focused on West and South European countries. Mortality, risk factor and economic data for nine West European and six South European countries were sourced from the World Health Organisation, the Global Burden of Disease study and the World Bank...
October 2023: The Lancet regional health. Europe
#29
REVIEW
Clare Strongman, Francesca Cavallerio, Matthew A Timmis, Andrew Morrison
The aim of this scoping review is to evaluate and summarize the existing literature that considers the validity and/or reliability of smartphone accelerometer applications when compared to 'gold standard' kinematic data collection (for example, motion capture). An electronic keyword search was performed on three databases to identify appropriate research. This research was then examined for details of measures and methodology and general study characteristics to identify related themes. No restrictions were placed on the date of publication, type of smartphone, or participant demographics...
October 20, 2023: Sensors
#30
JOURNAL ARTICLE
Devin M Howell, Timmy Li, Elizabeth Quellhorst, Jeffrey M Katz, Rohan Arora, Jonathan Berkowitz
BACKGROUND: Door-in to door-out (DIDO) time for large vessel occlusion (LVO) stroke is an emerging stroke performance measure. Initial presentation at a non-Comprehensive Stroke Center (CSC) requires a transfer process that minimizes delays. Our objective was to assess whether DIDO time for stroke patients was reduced after implementation of an AutoLaunch protocol for interfacility transfers. METHODS: This was a pre-post analysis of an AutoLaunch protocol for all acute stroke patients transferred to a CSC for mechanical thrombectomy...
2023: Open Access Emergency Medicine: OAEM
#31
JOURNAL ARTICLE
Michael Allon, Alian Al-Balas, Carlton J Young, Gary R Cutter, Timmy Lee
BACKGROUND: Current guidelines encourage placement of an arteriovenous (AV) fistula in patients with advanced CKD to avoid initiation of hemodialysis with a central venous catheter. However, the relative merits of predialysis placement of an AV fistula or graft have been poorly studied. METHODS: This study included 380 patients (mean age 59±14 years, 73% Black patients, 51% male) from a large academic medical center who underwent predialysis placement of an AV fistula (286) or AV graft (94)...
October 16, 2023: Clinical Journal of the American Society of Nephrology: CJASN
#32
JOURNAL ARTICLE
Koichiro Shinozaki, Pey-Jen Yu, Qiuping Zhou, Hugh A Cassiere, Stanley John, Daniel M Rolston, Nidhi Garg, Timmy Li, Jennifer Johnson, Kota Saeki, Taiki Goto, Yu Okuma, Santiago J Miyara, Kei Hayashida, Tomoaki Aoki, Vanessa K Wong, Ernesto P Molmenti, Joshua W Lampe, Lance B Becker
OBJECTIVE: Using a system, which accuracy is equivalent to the gold standard Douglas Bag (DB) technique for measuring oxygen consumption (VO2 ), carbon dioxide generation (VCO2 ), and respiratory quotient (RQ), we aimed to continuously measure these metabolic indicators and compare the values between post-cardiothoracic surgery and critical care patients. METHODS: This was a prospective, observational study conducted at a suburban, quaternary care teaching hospital...
October 16, 2023: BMC Pulmonary Medicine
#33
JOURNAL ARTICLE
Michael A Beckett, Peter N Horton, Michael B Hursthouse, James L Timmis
Two substituted phosphonium tetrahydoxidohexaoxidopentaborate(1-) salts, [i PrPPh3 ][B5 O6 (OH)4 ]·3.5H2 O ( 1 ) and [MePPh3 ][B5 O6 (OH)4 ]·B(OH)3 ·0.5H2 O ( 2 ), were prepared by templated self-assembly processes with good yields by crystallization from basic methanolic aqueous solutions primed with B(OH)3 and the appropriate phosphonium cation. Salts 1 and 2 were characterized by spectroscopic (NMR and IR) and thermal (TGA/DSC) analysis. Salts 1 and 2 were thermally decomposed in air at 800 °C to glassy solids via the anhydrous phosphonium polyborates that are formed at lower temperatures (<300 °C)...
September 29, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
#34
JOURNAL ARTICLE
Kevin To, Timmie Britton, Hung Ton-That
Innately present in tears, saliva and mucosal secretions, lysozyme provides a critical defensive strategy to the host by cleaving the β-1,4-glycosidic bonds between N-acetylmuramic acid and N-acetyl-D-glucosamine residues of peptidoglycan of invading bacteria, leading to bacterial lysis. To counter this class of cell wall hydrolase enzymes, bacteria produce several lysozyme inhibitors, a representative of which, MliC, was identified in Escherichia coli, Pseudomonas aeruginosa, and various bacterial species...
2024: Methods in Molecular Biology
#35
JOURNAL ARTICLE
Nathan M Money, Elizabeth R Wolf, Jennifer R Marin, Danni Liang, Elizabeth T Thomas, Timmy Ho
No abstract text is available yet for this article.
September 25, 2023: Pediatrics
#36
JOURNAL ARTICLE
Simon Godwin, Shana Elkind, Timmy Carey, Kimberly DiGiandomenico, Alexa Balbo, Jemma Blocksidge, Jessica Olson, Jess Miklosko, Leo Njongmeta, Francine Preston, Rachel Hodges
INTRODUCTION: This article provides a strategy by which a manufacturing process with a Biosafety Level 2 (BL2) designation can be downgraded to Biosafety Level 1 (BL1). The principles of the downgrading process are based on the robust contamination controls in clinical and commercial manufacturing, which typically are not part of Research and Development processes. These strict requirements along with the application of current Good Manufacturing Practice (cGMP) principles provide a framework by which processes can be suitably managed and controlled to mitigate biohazard risk, specifically for cell lines that may be contaminated with human pathogenic viral agents...
September 1, 2023: Applied Biosafety: Journal of the American Biological Safety Association
#37
JOURNAL ARTICLE
Timmy Strauss, Claudia Günther, Anja Schnabel, Christine Wolf, Gabriele Hahn, Min Ae Lee-Kirsch, Normi Brück
BACKGROUND: Juvenile dermatomyositis (jDM) is the most common idiopathic inflammatory myopathy of childhood. Amyopathic or hypomyopathic courses have been described. CASE PRESENTATION: We present the case of a 4-year-old patient with MDA5 antibody positive jDM and interstitial lung disease. In our patient, typical symptoms of jDM with classical skin lesions, arthritis, proximal muscle weakness, and ulcerative calcifications were observed. Due to the severity of the disease and the pulmonary changes, therapy with the Janus kinase (JAK) inhibitor ruxolitinib was added to the therapy with corticosteroids, intravenous immunoglobulins (IVIG) and hydroxychloroquine leading to a fast and sustained remission...
September 19, 2023: Pediatric Rheumatology Online Journal
#38
JOURNAL ARTICLE
Sidsel Nag, Gunhild Larsen, Judit Szarvas, Laura Elmlund Kohl Birkedahl, Gábor Máté Gulyás, Wojchiech Jakub Ciok, Timmie Mikkel Lagermann, Silva Tafaj, Susan Bradbury, Peter Collignon, Denise Daley, Victorien Dougnon, Kafayath Fabiyi, Boubacar Coulibaly, René Dembélé, Georgette Nikiema, Natama Magloire, Isidore Juste Ouindgueta, Zenat Zebin Hossain, Anowara Begum, Deyan Donchev, Mathew Diggle, LeeAnn Turnbull, Simon Lévesque, Livia Berlinger, Kirstine Kobberoe Sogaard, Paula Diaz Guevara, Carolina Duarte Valderrama, Panagiota Maikanti, Jana Amlerova, Pavel Drevinek, Jan Tkadlec, Milica Dilas, Achim Kaasch, Henrik Torkil Westh, Mohamed Azzedine Bachtarzi, Wahiba Amhis, Carolina Elisabeth Satán Salazar, JoséEduardo Villacis, Mária Angeles Dominguez Lúzon, Dámaris Berbel Palau, Claire Duployez, Maxime Paluche, Solomon Asante-Sefa, Mie Moller, Margaret Ip, Ivana Mareković, Agnes Pál-Sonnevend, Clementiza Elvezia Cocuzza, Asta Dambrauskiene, Alexandre Macanze, Anelsio Cossa, Inácio Mandomando, Philip Nwajiobi-Princewill, Iruka N Okeke, Aderemi O Kehinde, Ini Adebiyi, Ifeoluwa Akintayo, Oluwafemi Popoola, Anthony Onipede, Anita Blomfeldt, Nora Elisabeth Nyquist, Kiri Bocker, James Ussher, Amjad Ali, Nimat Ullah, Habibullah Khan, Natalie Weiler Gustafson, Ikhlas Jarrar, Arif Al-Hamad, Viravarn Luvira, Wantana Paveenkittiporn, Irmak Baran, James C L Mwansa, Linda Sikakwa, Kaunda Yamba, Rene Sjogren Hendriksen, Frank Moller Aarestrup
The Two Weeks in the World research project has resulted in a dataset of 3087 clinically relevant bacterial genomes with pertaining metadata, collected from 59 diagnostic units in 35 countries around the world during 2020. A relational database is available with metadata and summary data from selected bioinformatic analysis, such as species prediction and identification of acquired resistance genes.
September 16, 2023: Scientific Data
#39
JOURNAL ARTICLE
Pascal M Burger, Gianluigi Savarese, Jasper Tromp, Carly Adamson, Pardeep S Jhund, Lina Benson, Camilla Hage, Wan Ting Tay, Scott D Solomon, Milton Packer, Xavier Rossello, John W McEvoy, Dirk De Bacquer, Adam Timmis, Panos Vardas, Ian M Graham, Emanuele Di Angelantonio, Frank L J Visseren, John J V McMurray, Carolyn S P Lam, Lars H Lund, Stefan Koudstaal, Jannick A N Dorresteijn, Arend Mosterd
AIMS: Although trials have proven the group-level effectiveness of various therapies for heart failure with reduced ejection fraction (HFrEF), important differences in absolute effectiveness exist between individuals. We developed and validated the LIFEtime-perspective for Heart Failure (LIFE-HF) model for the prediction of individual (lifetime) risk and treatment benefit in patients with HFrEF. METHODS AND RESULTS: Cox proportional hazards functions with age as the time scale were developed in the PARADIGM-HF and ATMOSPHERE trials (n = 15 415)...
November 2023: European Journal of Heart Failure
#40
JOURNAL ARTICLE
Mike Angus, Edgar Buchanan, Léni K Le Goff, Emma Hart, Agoston E Eiben, Matteo De Carlo, Alan F Winfield, Matthew F Hale, Robert Woolley, Jon Timmis, Andy M Tyrrell
The evolutionary robotics field offers the possibility of autonomously generating robots that are adapted to desired tasks by iteratively optimising across successive generations of robots with varying configurations until a high-performing candidate is found. The prohibitive time and cost of actually building this many robots means that most evolutionary robotics work is conducted in simulation, but to apply evolved robots to real-world problems, they must be implemented in hardware, which brings new challenges...
2023: Frontiers in Robotics and AI
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