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https://www.readbyqxmd.com/read/28215405/screening-of-over-100-drugs-in-horse-urine-using-automated-on-line-solid-phase-extraction-coupled-to-liquid-chromatography-high-resolution-mass-spectrometry-for-doping-control
#1
W H Kwok, Timmy L S Choi, Yeuki Y K Tsoi, Gary N W Leung, Terence S M Wan
A fast method for the direct analysis of enzyme-hydrolysed horse urine using an automated on-line solid-phase extraction (SPE) coupled to a liquid-chromatography/high resolution mass spectrometer was developed. Over 100 drugs of diverse drug classes could be simultaneously detected in horse urine at sub to low parts per billion levels. Urine sample was first hydrolysed by β-glucuronidase to release conjugated drugs, followed by centrifugal filtration. The filtrate (1mL) was directly injected into an on-line SPE system consisting of a pre-column filter and a SPE cartridge column for the separation of analytes from matrix components...
February 14, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28194620/mathematical-modeling-of-learning-from-an-inconsistent-source-a-nonlinear-approach
#2
Timmy Ma, Natalia L Komarova
Continuing the discussion of how children can modify and regularize linguistic inputs from adults, we present a new interpretation of existing algorithms to model and investigate the process of a learner learning from an inconsistent source. On the basis of this approach is a (possibly nonlinear) function (the update function) that relates the current state of the learner with an increment that it receives upon processing the source's input, in a sequence of updates. The model can be considered a nonlinear generalization of the classic Bush-Mosteller algorithm...
February 13, 2017: Bulletin of Mathematical Biology
https://www.readbyqxmd.com/read/28190410/the-effect-of-older-age-on-ems-use-for-transportation-to-an-emergency-department
#3
Courtney M C Jones, Erin B Wasserman, Timmy Li, Ashley Amidon, Marissa Abbott, Manish N Shah
: Introduction Previous studies have found that older adults are more likely to use Emergency Medical Services (EMS) than younger adults, but the reasons for this remain understudied. Hypothesis/Problem This study aimed to determine if older age is associated with using EMS for transportation to an emergency department (ED) after controlling for confounding variables. METHODS: A cross-sectional survey study was conducted at a large academic medical center. Data on previous medical history, chief complaint, self-perceived illness severity, demographic information, and mode of arrival to the ED were collected on all subjects...
February 13, 2017: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/28167942/distinct-cytokine-and-chemokine-profiles-in-autism-spectrum-disorders
#4
Yvonne M Y Han, Winnie K Y Cheung, Chun Kwok Wong, Sophia L Sze, Timmy W S Cheng, Michael K Yeung, Agnes S Chan
Previous studies have shown that immunological factors are involved in the pathogenesis of autism spectrum disorders (ASDs). However, this research has been conducted almost exclusively in Western contexts, and only a handful of studies on immune measures have been conducted in Asian populations, such as Chinese populations. The present study examined whether immunological abnormalities are associated with cognitive deficits and problem behaviors in Chinese children with ASD and whether these children show different immunological profiles...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28158307/aspasia-a-toolkit-for-evaluating-the-effects-of-biological-interventions-on-sbml-model-behaviour
#5
Stephanie Evans, Kieran Alden, Lourdes Cucurull-Sanchez, Christopher Larminie, Mark C Coles, Marika C Kullberg, Jon Timmis
A calibrated computational model reflects behaviours that are expected or observed in a complex system, providing a baseline upon which sensitivity analysis techniques can be used to analyse pathways that may impact model responses. However, calibration of a model where a behaviour depends on an intervention introduced after a defined time point is difficult, as model responses may be dependent on the conditions at the time the intervention is applied. We present ASPASIA (Automated Simulation Parameter Alteration and SensItivity Analysis), a cross-platform, open-source Java toolkit that addresses a key deficiency in software tools for understanding the impact an intervention has on system behaviour for models specified in Systems Biology Markup Language (SBML)...
February 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28106345/blood-based-detection-of-ras-mutations-to-guide-anti-egfr-therapy-in-colorectal-cancer-patients-concordance-of-results-from-circulating-tumor-dna-and-tissue-based-ras-testing
#6
Wolff Schmiegel, Rodney J Scott, Susan Dooley, Wendy Lewis, Cliff J Meldrum, Peter Pockney, Brian Draganic, Steve Smith, Chelsee Hewitt, Hazel Philimore, Amanda Lucas, Elva Shi, Kateh Namdarian, Timmy Chan, Danilo Acosta, Su Ping-Chang, Andrea Tannapfel, Anke Reinacher-Schick, Waldemar Uhl, Christian Teschendorf, Heiner Wolters, Josef Stern, Richard Viebahn, Helmut Friess, Klaus-Peter Janssen, Ulrich Nitsche, Julia Slotta-Huspenina, Michael Pohl, Deepak Vangala, Alexander Baraniskin, Barbara Dockhorn-Dworniczak, Susanne Hegewisch-Becker, Philippe Ronga, Daniel L Edelstein, Frederick S Jones, Stephan Hahn, Stephen B Fox
An accurate blood-based RAS mutation assay to determine eligibility of metastatic colorectal cancer (mCRC) patients for anti-EGFR therapy would benefit clinical practice by better informing decisions to administer treatment independent of tissue availability. The objective of this study was to determine the level of concordance between plasma and tissue RAS mutation status in patients with mCRC to gauge whether blood-based RAS mutation testing is a viable alternative to standard-of-care RAS tumor testing. RAS testing was performed on plasma samples from newly diagnosed metastatic patients, or from recurrent mCRC patients using the highly sensitive digital PCR technology, BEAMing (beads, emulsions, amplification, and magnetics), and compared with DNA sequencing data of respective FFPE (formalin-fixed paraffin-embedded) tumor samples...
February 2017: Molecular Oncology
https://www.readbyqxmd.com/read/28078099/aligning-the-planets-the-role-of-nurses-in-the-care-of-patients-with-non-st-elevation-myocardial-infarction
#7
Christi Deaton, Rachel Johnson, Maggie Evans, Adam Timmis, Justin Zaman, Harry Hemingway, Jacqueline Hughes, Gene Feder, Helen Cramer
BACKGROUND: Studies have shown variation in care for patients with non-ST elevation myocardial infarction (NSTEMI), including in the roles of specialist and advanced practice nurses in diagnosis, treatment and coordination of care. AIM: The aim of this study was to describe the roles and responsibilities of specialist and advanced practice nurses in providing care for patients with NSTEMI. METHODS: Secondary analysis of observational field notes and interviews from an ethnographic study of variation in care for NSTEMI patients in 10 UK hospitals conducted 2011-2012...
January 2017: Nursing Open
https://www.readbyqxmd.com/read/28054457/doping-control-analysis-of-lithium-in-horse-urine-and-plasma-by-inductively-coupled-plasma-mass-spectrometry
#8
Timmy L S Choi, Jenny K Y Wong, Emmie N M Ho, Wai Him Kwok, Gary N W Leung, Peter Curl, Terence S M Wan
Lithium salts are commonly prescribed to treat bipolar disorder in humans. They are effective for the treatment of acute mania and the prophylaxis of manic relapses through long-term use. Although there is no reported legitimate therapeutic use of lithium in horses, its potential mood-stabilizing effect, low cost, and ready availability make lithium salt a potential agent of abuse in equine sports, especially for equestrian competition horses. Lithium can be found in soil, plants, and water, as such it is naturally present in the equine body, thus a threshold is necessary to control its misuse in horses...
January 5, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28033161/relative-difficulties-of-daily-living-tasks-with-retinitis-pigmentosa
#9
Keziah Latham, Mohammad Baranian, Matthew A Timmis, Andy Fisher, Shahina Pardhan
PURPOSE: To determine the relative difficulty of activity of daily living tasks for people with retinitis pigmentosa (RP). METHODS: Participants with RP (n = 166) rated the difficulty of tasks (n = 43) underpinning the Dutch Activity Inventory goals of mobility indoors and outdoors, shopping, and using public transport. Demographic characteristics were also determined. Responses were Rasch analyzed to determine properties of the scale, derive unidimensional subscales, and consider differential item functioning (DIF)...
December 29, 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28017445/core-values-for-vaccine-evaluation
#10
James Kenneth Timmis, Fabio Rigat, Rino Rappuoli
Currently, most health economic modelling approaches tend to inadequately incorporate crucial disease-specific criteria and other attributes of benefit resulting from vaccination, which limits their utility for evaluating vaccines and, in consequence, for optimally guiding vaccine decision-making. Additionally, vaccine evaluation methods are frequently poorly standardised and non-transparent, leading to a potentially low level of accountability that can hinder acceptance of resulting decisions. To address these issues, we have considered whether it is possible to identify a set of universal vaccine-disease considerations, which we have called Core Values...
December 22, 2016: Vaccine
https://www.readbyqxmd.com/read/28017438/the-role-of-vaccines-and-vaccine-decision-making-to-achieve-the-goals-of-the-grand-convergence-in-public-health
#11
David C Kaslow, Jorge Kalil, David Bloom, Gianluca Breghi, Anna Maria Colucci, Ennio De Gregorio, Guru Madhavan, Genevieve Meier, Richard Seabrook, Xiaoning Xu
On 17 and 18 July 2015, a meeting in Siena jointly sponsored by ADITEC and GlaxoSmithKline (GSK) was held to review the goals of the Global Health 2035 Grand Convergence, to discuss current vaccine evaluation methods, and to determine the feasibility of reaching consensus on an assessment framework for comprehensively and accurately capturing the full benefits of vaccines. Through lectures and workshops, participants reached a consensus that Multi-Criteria-Decision-Analysis is a method suited to systematically account for the many variables needed to evaluate the broad benefits of vaccination, which include not only health system savings, but also societal benefits, including benefits to the family and increased productivity...
December 22, 2016: Vaccine
https://www.readbyqxmd.com/read/27965882/trial-of-optimal-personalised-care-after-treatment-for-gynaecological-cancer-topcat-g-a-study-protocol-for-a-randomised-feasibility-trial
#12
Kirstie Pye, Nicola Totton, Nicholas Stuart, Rhiannon Whitaker, Val Morrison, Rhiannon Tudor Edwards, Seow Tien Yeo, Laura J Timmis, Caryl Butterworth, Liz Hall, Tekendra Rai, Zoe Hoare, Richard D Neal, Clare Wilkinson, Simon Leeson
BACKGROUND: Gynaecological cancers are diagnosed in over 1000 women in Wales every year. We estimate that this is costing the National Health Service (NHS) in excess of £1 million per annum for routine follow-up appointments alone. Follow-up care is not evidence-based, and there are no definitive guidelines from The National Institute for Health and Care Excellence (NICE) for the type of follow-up that should be delivered. Standard care is to provide a regular medical review of the patient in a hospital-based outpatient clinic for a minimum of 5 years...
2016: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/27936755/spontaneous-vesiculation-and-ph-induced-disassembly-of-a-lysosomotropic-detergent-impacts-on-lysosomotropism-and-lysosomal-delivery
#13
Ana M Villamil Giraldo, Timmy Fyrner, Stefan Wennmalm, Atul N Parikh, Karin Öllinger, Thomas Ederth
Lysosomotropic detergents (LDs) selectively rupture lysosomal membranes through mechanisms that have yet to be characterized. A consensus view, currently, holds that LDs, which are weakly basic, diffuse across cellular membranes as monomers in an uncharged state, and via protonation in the acidic lysosomal compartment, they become trapped, accumulate, and subsequently solubilize the membrane and induce lysosomal membrane permeabilization. Here we demonstrate that the lysosomotropic detergent O-methyl-serine dodecylamide hydrochloride (MSDH) spontaneously assembles into vesicles at, and above, cytosolic pH, and that the vesicles disassemble as the pH reaches 6...
December 20, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/27933457/pristine-but-metal-rich-r%C3%A3-o-sucio-dirty-river-is-dominated-by-gallionella-and-other-iron-sulfur-oxidizing-microbes
#14
Alejandro Arce-Rodríguez, Fernando Puente-Sánchez, Roberto Avendaño, Eduardo Libby, Leonardo Rojas, Juan Carlos Cambronero, Dietmar H Pieper, Kenneth N Timmis, Max Chavarría
Whether the extreme conditions of acidity and heavy metal pollution of streams and rivers originating in pyritic formations are caused primarily by mining activities or by natural activities of metal-oxidizing microbes living within the geological formations is a subject of considerable controversy. Most microbiological studies of such waters have so far focused on acid mine drainage sites, which are heavily human-impacted environments, so it has been problematic to eliminate the human factor in the question of the origin of the key metal compounds...
December 8, 2016: Extremophiles: Life Under Extreme Conditions
https://www.readbyqxmd.com/read/27910221/a-routine-check-up-at-the-digital-medical-centre
#15
Kenneth N Timmis, James K Timmis
No abstract text is available yet for this article.
January 2017: Microbial Biotechnology
https://www.readbyqxmd.com/read/27897379/microbiomes-metabolic-errors-and-detection-of-performance-enhancing-drug-abuse-1-2
#16
Kenneth Timmis, James Kenneth Timmis
No abstract text is available yet for this article.
November 29, 2016: Environmental Microbiology Reports
https://www.readbyqxmd.com/read/27868380/microbiomes-metabolic-errors-and-detection-of-performance-enhancing-drug-abuse
#17
(no author information available yet)
No abstract text is available yet for this article.
November 21, 2016: Environmental Microbiology Reports
https://www.readbyqxmd.com/read/27863172/building-confidence-in-quantitative-systems-pharmacology-models-an-engineer-s-guide-to-exploring-the-rationale-in-model-design-and-development
#18
J Timmis, K Alden, P Andrews, E Clark, A Nellis, B Naylor, M Coles, P Kaye
This tutorial promotes good practice for exploring the rationale of systems pharmacology models. A safety systems engineering inspired notation approach provides much needed rigor and transparency in development and application of models for therapeutic discovery and design of intervention strategies. Structured arguments over a model's development, underpinning biological knowledge, and analyses of model behaviors are constructed to determine the confidence that a model is fit for the purpose for which it will be applied...
November 11, 2016: CPT: Pharmacometrics & Systems Pharmacology
https://www.readbyqxmd.com/read/27630181/predictors-of-initiation-for-predialysis-arteriovenous-fistula
#19
Alian Al-Balas, Timmy Lee, Carlton J Young, Jill Barker-Finkel, Michael Allon
BACKGROUND AND OBJECTIVES: The optimal timing of predialysis arteriovenous fistula surgery remains uncertain. We evaluated factors associated with hemodialysis initiation in patients undergoing predialysis arteriovenous fistula surgery and derived a model to predict future initiation of dialysis. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Our study retrospectively identified 308 patients undergoing predialysis arteriovenous fistula creation at a large medical center in 2006-2012 to determine whether they initiated hemodialysis...
September 14, 2016: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/27628175/automated-multi-objective-calibration-of-biological-agent-based-simulations
#20
Mark N Read, Kieran Alden, Louis M Rose, Jon Timmis
Computational agent-based simulation (ABS) is increasingly used to complement laboratory techniques in advancing our understanding of biological systems. Calibration, the identification of parameter values that align simulation with biological behaviours, becomes challenging as increasingly complex biological domains are simulated. Complex domains cannot be characterized by single metrics alone, rendering simulation calibration a fundamentally multi-metric optimization problem that typical calibration techniques cannot handle...
September 2016: Journal of the Royal Society, Interface
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