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https://www.readbyqxmd.com/read/27933457/pristine-but-metal-rich-r%C3%A3-o-sucio-dirty-river-is-dominated-by-gallionella-and-other-iron-sulfur-oxidizing-microbes
#1
Alejandro Arce-Rodríguez, Fernando Puente-Sánchez, Roberto Avendaño, Eduardo Libby, Leonardo Rojas, Juan Carlos Cambronero, Dietmar H Pieper, Kenneth N Timmis, Max Chavarría
Whether the extreme conditions of acidity and heavy metal pollution of streams and rivers originating in pyritic formations are caused primarily by mining activities or by natural activities of metal-oxidizing microbes living within the geological formations is a subject of considerable controversy. Most microbiological studies of such waters have so far focused on acid mine drainage sites, which are heavily human-impacted environments, so it has been problematic to eliminate the human factor in the question of the origin of the key metal compounds...
December 8, 2016: Extremophiles: Life Under Extreme Conditions
https://www.readbyqxmd.com/read/27910221/a-routine-check-up-at-the-digital-medical-centre
#2
Kenneth N Timmis, James K Timmis
No abstract text is available yet for this article.
December 1, 2016: Microbial Biotechnology
https://www.readbyqxmd.com/read/27897379/microbiomes-metabolic-errors-and-detection-of-performance-enhancing-drug-abuse-1-2
#3
Kenneth Timmis, James Kenneth Timmis
No abstract text is available yet for this article.
November 29, 2016: Environmental Microbiology Reports
https://www.readbyqxmd.com/read/27868380/microbiomes-metabolic-errors-and-detection-of-performance-enhancing-drug-abuse
#4
Kenneth Timmis, James Kenneth Timmis
No abstract text is available yet for this article.
November 21, 2016: Environmental Microbiology Reports
https://www.readbyqxmd.com/read/27863172/building-confidence-in-quantitative-systems-pharmacology-models-an-engineer-s-guide-to-exploring-the-rationale-in-model-design-and-development
#5
J Timmis, K Alden, P Andrews, E Clark, A Nellis, B Naylor, M Coles, P Kaye
This tutorial promotes good practice for exploring the rationale of systems pharmacology models. A safety systems engineering inspired notation approach provides much needed rigour and transparency in development and application of models for therapeutic discovery and design of intervention strategies. Structured arguments over a model's development, underpinning biological knowledge, and analyses of model behaviours, are constructed to determine the confidence that a model is fit for the purpose for which it will be applied...
November 11, 2016: CPT: Pharmacometrics & Systems Pharmacology
https://www.readbyqxmd.com/read/27630181/predictors-of-initiation-for-predialysis-arteriovenous-fistula
#6
Alian Al-Balas, Timmy Lee, Carlton J Young, Jill Barker-Finkel, Michael Allon
BACKGROUND AND OBJECTIVES: The optimal timing of predialysis arteriovenous fistula surgery remains uncertain. We evaluated factors associated with hemodialysis initiation in patients undergoing predialysis arteriovenous fistula surgery and derived a model to predict future initiation of dialysis. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Our study retrospectively identified 308 patients undergoing predialysis arteriovenous fistula creation at a large medical center in 2006-2012 to determine whether they initiated hemodialysis...
September 14, 2016: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/27628175/automated-multi-objective-calibration-of-biological-agent-based-simulations
#7
Mark N Read, Kieran Alden, Louis M Rose, Jon Timmis
Computational agent-based simulation (ABS) is increasingly used to complement laboratory techniques in advancing our understanding of biological systems. Calibration, the identification of parameter values that align simulation with biological behaviours, becomes challenging as increasingly complex biological domains are simulated. Complex domains cannot be characterized by single metrics alone, rendering simulation calibration a fundamentally multi-metric optimization problem that typical calibration techniques cannot handle...
September 2016: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/27621836/international-guideline-changes-and-the-incidence-of-infective-endocarditis-a-systematic-review
#8
Omeair Khan, Ahmed Mohamed Abdel Shafi, Adam Timmis
The objective of this study was to determine the impact on incident infective endocarditis (IE) of guideline recommendations to restrict indications for antibiotic prophylaxis. We conducted a systematic review according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guideline. PubMed and EMBASE databases were searched for articles published between 2007 and 2015 using mesh terms relevant to the research question. Included were English language articles published after 2009 that provided estimates of IE incidence before-and-after major international guideline changes...
2016: Open Heart
https://www.readbyqxmd.com/read/27591036/orolingual-angioedema-to-alteplase-identify-counsel-and-monitor-at-risk-patients
#9
Christopher Timmis, Elliot Epstein, Mohmad Salim
Orolingual angioedema (OLA) is a known complication of intravenous alteplase used to treat ischaemic stroke. The incidence may be as high as 5.1%. ACE inhibitors are thought to increase the risk of developing this potentially life-threatening complication. This case report demonstrates how we may improve in the identification of risk factors in the history; the counselling of patients appropriately; in seeking alternative therapies such as mechanical thrombectomy; and in the monitoring of patients for signs of OLA once alteplase has been given...
2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27589606/leukocyte-motility-models-assessed-through-simulation-and-multi-objective-optimization-based-model-selection
#10
Mark N Read, Jacqueline Bailey, Jon Timmis, Tatyana Chtanova
The advent of two-photon microscopy now reveals unprecedented, detailed spatio-temporal data on cellular motility and interactions in vivo. Understanding cellular motility patterns is key to gaining insight into the development and possible manipulation of the immune response. Computational simulation has become an established technique for understanding immune processes and evaluating hypotheses in the context of experimental data, and there is clear scope to integrate microscopy-informed motility dynamics...
September 2016: PLoS Computational Biology
https://www.readbyqxmd.com/read/27577241/association-of-peritonitis-with-hemodialysis-catheter-dependence-after-modality-switch
#11
Timmy Lee, Mae Thamer, Yi Zhang, Qian Zhang, Michael Allon
BACKGROUND AND OBJECTIVES: Few studies have evaluated vascular access use after transition from peritoneal dialysis to hemodialysis. Our study characterizes vascular access use after switch to hemodialysis and its effect on patient mortality and evaluates whether a peritonitis event preceding the switch was associated with the timing of permanent vascular access placement and use. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: The US Renal Data System data were used to evaluate the establishment of a permanent vascular access in 1165 incident Medicare-insured adult patients on dialysis who initiated peritoneal dialysis between July 1, 2010 and June 30, 2011 and switched to hemodialysis within 1 year...
November 7, 2016: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/27574717/association-of-clinical-factors-and-therapeutic-strategies-with-improvements-in-survival-following-non-st-elevation-myocardial-infarction-2003-2013
#12
Marlous Hall, Tatendashe B Dondo, Andrew T Yan, Shaun G Goodman, Héctor Bueno, Derek P Chew, David Brieger, Adam Timmis, Phillip D Batin, John E Deanfield, Harry Hemingway, Keith A A Fox, Christopher P Gale
IMPORTANCE: International studies report a decline in mortality following non-ST-elevation myocardial infarction (NSTEMI). Whether this is due to lower baseline risk or increased utilization of guideline-indicated treatments is unknown. OBJECTIVE: To determine whether changes in characteristics of patients with NSTEMI are associated with improvements in outcomes. DESIGN, SETTING, AND PARTICIPANTS: Data on patients with NSTEMI in 247 hospitals in England and Wales were obtained from the Myocardial Ischaemia National Audit Project between January 1, 2003, and June 30, 2013 (final follow-up, December 31, 2013)...
September 13, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27574334/quality-indicators-for-acute-myocardial-infarction-a-position-paper-of-the-acute-cardiovascular-care-association
#13
Francois Schiele, Chris P Gale, Eric Bonnefoy, Frederic Capuano, Marc J Claeys, Nicolas Danchin, Keith Aa Fox, Kurt Huber, Zaza Iakobishvili, Maddalena Lettino, Tom Quinn, Maria Rubini Gimenez, Hans E Bøtker, Eva Swahn, Adam Timmis, Marco Tubaro, Christiaan Vrints, David Walker, Doron Zahger, Uwe Zeymer, Hector Bueno
Evaluation of quality of care is an integral part of modern healthcare, and has become an indispensable tool for health authorities, the public, the press and patients. However, measuring quality of care is difficult, because it is a multifactorial and multidimensional concept that cannot be estimated solely on the basis of patients' clinical outcomes. Thus, measuring the process of care through quality indicators (QIs) has become a widely used practice in this context. Other professional societies have published QIs for the evaluation of quality of care in the context of acute myocardial infarction (AMI), but no such indicators exist in Europe...
August 29, 2016: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/27574333/impact-of-initial-hospital-diagnosis-on-mortality-for-acute-myocardial-infarction-a-national-cohort-study
#14
Jianhua Wu, Chris P Gale, Marlous Hall, Tatendashe B Dondo, Elizabeth Metcalfe, Ged Oliver, Phil D Batin, Harry Hemingway, Adam Timmis, Robert M West
AIMS: Early and accurate diagnosis of acute myocardial infarction is central to successful treatment and improved outcomes. We aimed to investigate the impact of the initial hospital diagnosis on mortality for patients with acute myocardial infarction. METHODS AND RESULTS: Cohort study using data from the Myocardial Ischaemia National Audit Project of patients discharged with a final diagnosis of ST-elevation myocardial infarction (STEMI, n=221,635) and non-STEMI (NSTEMI, n=342,777) between 1 April 2004 and 31 March 2013 in all acute hospitals (n = 243) in England and Wales...
August 29, 2016: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/27571414/statistical-techniques-complement-uml-when-developing-domain-models-of-complex-dynamical-biosystems
#15
Richard A Williams, Jon Timmis, Eva E Qwarnstrom
Computational modelling and simulation is increasingly being used to complement traditional wet-lab techniques when investigating the mechanistic behaviours of complex biological systems. In order to ensure computational models are fit for purpose, it is essential that the abstracted view of biology captured in the computational model, is clearly and unambiguously defined within a conceptual model of the biological domain (a domain model), that acts to accurately represent the biological system and to document the functional requirements for the resultant computational model...
2016: PloS One
https://www.readbyqxmd.com/read/27570364/modelling-the-impact-and-control-of-an-infectious-disease-in-a-plant-nursery-with-infected-plant-material-inputs
#16
Andrew M Bate, Glyn Jones, Adam Kleczkowski, Alan MacLeod, Rebecca Naylor, Jon Timmis, Julia Touza, Piran C L White
The ornamental plant trade has been identified as a key introduction pathway for plant pathogens. Establishing effective biosecurity measures to reduce the risk of plant pathogen outbreaks in the live plant trade is therefore important. Management of invasive pathogens has been identified as a weakest link public good, and thus is reliant on the actions of individual private agents. This paper therefore provides an analysis of the impact of the private agents' biosecurity decisions on pathogen prevention and control within the plant trade...
August 24, 2016: Ecological Modelling
https://www.readbyqxmd.com/read/27509838/microbial-biotechnology-2020
#17
EDITORIAL
Kenneth Timmis, Juan Luis Ramos, Willem de Vos, Siegfried Vlaeminck, Auxi Prieto, Antoine Danchin, Willy Verstraete, Victor de Lorenzo
No abstract text is available yet for this article.
September 2016: Microbial Biotechnology
https://www.readbyqxmd.com/read/27504130/clinical-applications-of-custom-made-vaginal-cylinders-constructed-using-three-dimensional-printing-technology
#18
Rajni Sethi, Adam Cunha, Katherine Mellis, Timmy Siauw, Chris Diederich, Jean Pouliot, I-Chow Hsu
PURPOSE: Three-dimensional (3D) printing technology allows physicians to rapidly create customized devices for patients. We report our initial clinical experience using this technology to create custom applicators for vaginal brachytherapy. MATERIAL AND METHODS: Three brachytherapy patients with unique clinical needs were identified as likely to benefit from a customized vaginal applicator. Patient 1 underwent intracavitary vaginal cuff brachytherapy after hysterectomy and chemotherapy for stage IA papillary serous endometrial cancer using a custom printed 2...
June 2016: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/27406646/geographic-variation-in-the-treatment-of-non-st-segment-myocardial-infarction-in-the-english-national-health-service-a-cohort-study
#19
T B Dondo, M Hall, A D Timmis, A T Yan, P D Batin, G Oliver, O A Alabas, P Norman, J E Deanfield, K Bloor, H Hemingway, C P Gale
OBJECTIVES: To investigate geographic variation in guideline-indicated treatments for non-ST-elevation myocardial infarction (NSTEMI) in the English National Health Service (NHS). DESIGN: Cohort study using registry data from the Myocardial Ischaemia National Audit Project. SETTING: All Clinical Commissioning Groups (CCGs) (n=211) in the English NHS. PARTICIPANTS: 357 228 patients with NSTEMI between 1 January 2003 and 30 June 2013...
July 12, 2016: BMJ Open
https://www.readbyqxmd.com/read/27401527/new-insights-into-dialysis-vascular-access-molecular-targets-in-arteriovenous-fistula-and-arteriovenous-graft-failure-and-their-potential-to-improve-vascular-access-outcomes
#20
Timmy Lee, Sanjay Misra
Vascular access dysfunction remains a major cause of morbidity and mortality in hemodialysis patients. At present there are few effective therapies for this clinical problem. The poor understanding of the pathobiology that leads to arteriovenous fistula (AVF) and graft (AVG) dysfunction remains a critical barrier to development of novel and effective therapies. However, in recent years we have made substantial progress in our understanding of the mechanisms of vascular access dysfunction. This article presents recent advances and new insights into the pathobiology of AVF and AVG dysfunction and highlights potential therapeutic targets to improve vascular access outcomes...
August 8, 2016: Clinical Journal of the American Society of Nephrology: CJASN
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