keyword
https://read.qxmd.com/read/38462475/mpox-illness-narratives-stigmatising-care-and-recovery-during-and-after-an-emergency-outbreak
#1
JOURNAL ARTICLE
Anthony K J Smith, Daniel Storer, Kari Lancaster, Bridget Haire, Christy E Newman, Sara Paparini, James MacGibbon, Vincent J Cornelisse, Timothy R Broady, Timmy Lockwood, Anna McNulty, Valerie Delpech, Martin Holt
In May 2022, a global outbreak of mpox (formerly monkeypox virus) affected thousands of mainly gay and bisexual men. Mpox is usually a time-limited illness that can involve fever, pain, and skin lesions, but may require hospitalisation. There is scant research into the firsthand experiences of people affected by mpox, including experiences of symptoms, healthcare, and recovery. This study considers the different illness narratives of people who experienced mpox in Australia in 2022. In-depth interviews and 6-month follow-up interviews were conducted with 16 people, including 13 people diagnosed with mpox and three close contacts...
March 10, 2024: Qualitative Health Research
https://read.qxmd.com/read/38423830/difficult-at-dusk-illuminating-the-debate-on-cricket-ball-visibility
#2
JOURNAL ARTICLE
John J Maule, Robert Maguire, Matthew A Timmis, Oliver R Runswick, Luke Wilkins, David L Mann, Stephen J Dain, Jenny M Bosten, Peter M Allen
OBJECTIVES: Investigate the visibility of new and old red, white and pink cricket balls under lighting and background conditions experienced during a day-night cricket match. DESIGN: We modelled the luminance contrast signals available for a typical observer for a ball against backgrounds in a professional cricket ground, at different times of day. METHODS: Spectral reflectance (light reflected as a function of wavelength) was derived from laboratory measurements of new and old red, white and pink balls...
February 20, 2024: Journal of Science and Medicine in Sport
https://read.qxmd.com/read/38423469/covid-19-infection-increases-the-development-of-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis-a-retrospective-cohort-analysis
#3
JOURNAL ARTICLE
Kristen K Curtis, Meghan M Dillan, Timmie R Sharma, Joseph Piktel
No abstract text is available yet for this article.
February 27, 2024: Journal of the American Academy of Dermatology
https://read.qxmd.com/read/38352341/characterization-and-functional-analysis-of-toxoplasma-golgi-associated-proteins-identified-by-proximity-labelling
#4
Rebecca R Pasquarelli, Justin J Quan, Vivian Yang, Timmie A Britton, Jihui Sha, James A Wohlschlegel, Peter J Bradley
UNLABELLED: Toxoplasma gondii possesses a highly polarized secretory pathway that contains both broadly conserved eukaryotic organelles and unique apicomplexan organelles which play essential roles in the parasite's lytic cycle. As in other eukaryotes, the T. gondii Golgi apparatus sorts and modifies proteins prior to their distribution to downstream organelles. Many of the typical trafficking factors found involved in these processes are missing from apicomplexan genomes, suggesting that these parasites have evolved unique proteins to fill these roles...
February 3, 2024: bioRxiv
https://read.qxmd.com/read/38301368/low-respiratory-quotient-correlates-with-high-mortality-in-patients-undergoing-mechanical-ventilation
#5
JOURNAL ARTICLE
Koichiro Shinozaki, Pey-Jen Yu, Qiuping Zhou, Hugh A Cassiere, Stanley John, Daniel M Rolston, Nidhi Garg, Timmy Li, Jennifer Johnson, Kota Saeki, Taiki Goto, Yu Okuma, Santiago J Miyara, Kei Hayashida, Tomoaki Aoki, Vanessa K Wong, Ernesto P Molmenti, Joshua W Lampe, Lance B Becker
OBJECTIVE: Oxygen consumption (VO2 ), carbon dioxide generation (VCO2 ), and respiratory quotient (RQ), which is the ratio of VO2 to VCO2 , are critical indicators of human metabolism. To seek a link between the patient's metabolism and pathophysiology of critical illness, we investigated the correlation of these values with mortality in critical care patients. METHODS: This was a prospective, observational study conducted at a suburban, quaternary care teaching hospital...
January 11, 2024: American Journal of Emergency Medicine
https://read.qxmd.com/read/38288237/a-rare-case-of-cardiac-tamponade-induced-by-chronic-lymphocytic-leukemia
#6
Catherine G Raciti, Hazem Alakhras, Kateryna Strubchevska, Steven Timmis, Marko Kozyk
While cardiac tamponade is a commonly recognized complication in solid organ malignancies and acute leukemias, instances of cardiac involvement in the context of chronic hematologic malignancies, such as chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), are rarely observed. A 66-year-old male, with a history of stage IV CLL/SLL, presented with three weeks of worsening edema, orthopnea, and dyspnea. Two days after admission, an echocardiogram revealed a large circumferential pericardial effusion...
December 2023: Curēus
https://read.qxmd.com/read/38268992/an-undifferentiated-primary-mediastinal-carcinoma-compressing-the-main-pulmonary-artery-a-rare-cause-of-right-ventricular-strain
#7
Ali Khreisat, Tanya Amal, David M Howell, Steven Timmis
Undifferentiated carcinoma (or poorly differentiated carcinoma) of the mediastinum is a relatively rare pathological variant of anterior mediastinal tumors. Pathologists usually use the term to describe an epithelial tumor with no histological features that enable the identification of its site of origin. Invasion of adjacent vital cardiopulmonary structures is among the most problematic complications of anterior mediastinal masses. We report a case of a 60-year-old male presenting with easy fatiguability, significant weight loss, and chest pain...
January 2024: Curēus
https://read.qxmd.com/read/38240812/-juvenile-localized-scleroderma
#8
REVIEW
Timmy Strauss, Claudia Günther, Normi Brück
Juvenile scleroderma, often referred to as juvenile localized scleroderma or "morphea", is a rare inflammatory disease of the skin and skin-related structures, accompanied by local sclerosis and tissue fibrosis. Depending on the clinical manifestation, four different subtypes can be defined: limited, generalized, linear, and mixed. To prevent possible sequelae of the disease, the diagnosis should be made as early as possible and therapy should be initiated at specialized centers in multiprofessional pediatric and dermatologic collaboration...
January 19, 2024: Dermatologie (Heidelb)
https://read.qxmd.com/read/38205986/the-accuracy-of-predictive-analytics-in-forecasting-emergency-department-volume-before-and-after-onset-of-covid-19
#9
JOURNAL ARTICLE
Anthony M Napoli, Rachel Smith-Shain, Timmy Lin, Janette Baird
INTRODUCTION: Big data and improved analytic techniques, such as triple exponential smoothing (TES), allow for prediction of emergency department (ED) volume. We sought to determine 1) which method of TES was most accurate in predicting pre-coronavirus 2019 (COVID-19), during COVID-19, and post-COVID-19 ED volume; 2) how the pandemic would affect TES prediction accuracy; and 3) whether TES would regain its pre-COVID-19 accuracy in the early post-pandemic period. METHODS: We studied monthly volumes of four EDs with a combined annual census of approximately 250,000 visits in the two years prior to, during the 25-month COVID-19 pandemic, and the 14 months following...
January 2024: Western Journal of Emergency Medicine
https://read.qxmd.com/read/38180527/one-train-may-hide-another-two-cases-of-co-occurring-primary-familial-brain-calcification-and-alzheimer-s-disease
#10
JOURNAL ARTICLE
Andrea Timmi, Alexandre Morin, Olivier Guillin, Gaël Nicolas
Primary familial brain calcification (PFBC) is a rare disorder that can manifest with a wide spectrum of motor, cognitive, and psychiatric symptoms or even remain asymptomatic. Alzheimer disease (AD) is a common condition that typically starts as a progressive amnestic disorder and progresses to major cognitive impairment. Accurately attributing an etiology to cognitive impairment can sometimes be challenging, especially when multiple pathologies with potentially overlapping symptomatology contribute to the clinical phenotype...
January 5, 2024: Journal of Molecular Neuroscience: MN
https://read.qxmd.com/read/38146839/ethylene-inhibits-photosynthesis-via-temporally-distinct-responses-in-tomato-plants
#11
JOURNAL ARTICLE
Petar Mohorović, Batist Geldhof, Kristof Holsteens, Marilien Rinia, Stijn Daems, Timmy Reijnders, Johan Ceusters, Wim Van den Ende, Bram Van de Poel
Ethylene is a volatile plant hormone that regulates many developmental processes and responses towards (a)biotic stress. Studies have shown that high levels of ethylene repress vegetative growth in many important crops, including tomato (Solanum lycopersicum), possibly by inhibiting photosynthesis. We investigated the temporal effects of ethylene on young tomato plants using an automated ethylene gassing system to monitor the physiological, biochemical, and molecular responses through time-course RNA-seq of a photosynthetically active source leaf...
December 26, 2023: Plant Physiology
https://read.qxmd.com/read/38141382/-ageing-well-discursive-constructions-of-ageing-and-health-in-the-public-reach-of-a-national-longitudinal-study-on-ageing
#12
JOURNAL ARTICLE
Gerard Fealy, Matteo Di Placido, Deirdre O'Donnell, Jonathan Drennan, Fiona Timmins, Marlize Barnard, Catherine Blake, Michael Connolly, Sarah Donnelly, Gerardine Doyle, Kelly Fitzgerald, Timmy Frawley, Paul Gallagher, Suzanne Guerin, Emanuela Mangiarotti, Jonathan McNulty, Doreen Mucheru, Desmond O'Neill, Ricardo Segurado, Diarmuid Stokes, Mary Ryder, Yeter Sinem Üzar Özçetin, John Wells, Anto Čartolovni
Established in 2006, the Irish Longitudinal Study on Ageing (TILDA) investigates the health, economic and social circumstances of a nationally-representative sample of people aged fifty years and older in a series of biennial data collection waves. Irish newspapers have been reporting the results of TILDA for over a decade and a half, and their texts represent reports of scientific research distilled through the pen of journalists. In their totality, their texts constitute a public discourse on ageing and health...
December 19, 2023: Social Science & Medicine
https://read.qxmd.com/read/38130886/evaluating-consistency-of-physical-activity-and-exercise-prescription-in-the-uk-for-people-with-diabetes-a-delphi-study
#13
JOURNAL ARTICLE
Clare Strongman, Francesca Cavallerio, Matthew A Timmis, Andrew Morrison
INTRODUCTION: Increased physical activity is recommended as a cost-effective measure to tackle long-term management of people with diabetes, but research on interventions lacks consistency in terms of effective duration and modality. METHODS: The aim of this study was to evaluate expert consensus on exercise and physical activity prescription via a three-round Delphi study conducted with 45 UK-based health and fitness professionals experienced in prescribing exercise or physical activity to people with diabetes...
2023: Front Clin Diabetes Healthc
https://read.qxmd.com/read/38130171/trends-in-low-value-care-among-children-s-hospitals
#14
JOURNAL ARTICLE
Samantha A House, Jennifer R Marin, Eric R Coon, Shawn L Ralston, Matthew Hall, Heidi Gruhler De Souza, Timmy Ho, Mario Reyes, Alan R Schroeder
BACKGROUND AND OBJECTIVES: Longitudinal pediatric low-value care (LVC) trends are not well established. We used the Pediatric Health Information System LVC Calculator, which measures utilization of 30 nonevidenced-based services, to report 7-year LVC trends. METHODS: This retrospective cohort study applied the LVC Calculator to emergency department (ED) and hospital encounters from January 1, 2016, to December 31, 2022. We used generalized estimating equation models accounting for hospital clustering to assess temporal changes in LVC...
December 22, 2023: Pediatrics
https://read.qxmd.com/read/38123618/effects-of-endothelial-nitric-oxide-synthase-on-mouse-arteriovenous-fistula-hemodynamics
#15
JOURNAL ARTICLE
Shelly Baltazar, Hannah Northrup, Joshua Chang, Maheshika Somarathna, Tatyana Isayeva Waldrop, Timmy Lee, Yan-Ting Shiu
Newly created arteriovenous fistulas (AVFs) often fail to mature for dialysis use due to disturbed blood flow at and near the AVF anastomosis. The disturbed flow inhibits the endothelial nitric oxide synthase (NOS3) pathway, thus decreasing the production of nitric oxide, a vasodilator. Previously, our group reported that NOS3 expression levels affect AVF lumen size in a mouse model. In this study, we performed MRI-based computational fluid dynamics simulations to investigate the hemodynamical parameters (velocity, wall shear stress (WSS), and vorticity) in a mouse AVF model at day 7 and day 21 post-AVF creation using three NOS3 strains: overexpression (OE), knockout (KO), and wild-type (WT) control...
December 20, 2023: Scientific Reports
https://read.qxmd.com/read/38059640/the-respiratory-enzyme-complex-rnf-is-vital-for-metabolic-adaptation-and-virulence-in-fusobacterium-nucleatum
#16
JOURNAL ARTICLE
Timmie A Britton, Chenggang Wu, Yi-Wei Chen, Dana Franklin, Yimin Chen, Martha I Camacho, Truc T Luong, Asis Das, Hung Ton-That
This paper illuminates the significant question of how the oral commensal Fusobacterium nucleatum adapts to the metabolically changing environments of several extra-oral sites such as placenta and colon to promote various diseases as an opportunistic pathogen. We demonstrate here that the highly conserved <u>R</u>hodobacter <u>n</u>itrogen-<u>f</u>ixation complex, commonly known as Rnf complex, is key to fusobacterial metabolic adaptation and virulence. Genetic disruption of this Rnf complex causes global defects in polymicrobial interaction, biofilm formation, cell growth and morphology, hydrogen sulfide production, and ATP synthesis...
December 7, 2023: MBio
https://read.qxmd.com/read/38013227/enhancing-the-nursing-profession-s-awareness-of-neurodiversity
#17
EDITORIAL
Timmy Frawley, Blánaid Gavin, Charlotte Valeur, Karen Van Morin
No abstract text is available yet for this article.
November 27, 2023: Journal of Clinical Nursing
https://read.qxmd.com/read/37987565/mating-system-is-associated-with-seed-phenotypes-upon-loss-of-rna-directed-dna-methylation-in-brassicaceae
#18
JOURNAL ARTICLE
Kelly J Dew-Budd, Hiu Tung Chow, Timmy Kendall, Brandon C David, James A Rozelle, Rebecca A Mosher, Mark A Beilstein
In plants, de novo DNA methylation is guided by 24-nt short interfering (si)RNAs in a process called RNA-directed DNA methylation (RdDM). Primarily targeted at transposons, RdDM causes transcriptional silencing and can indirectly influence expression of neighboring genes. During reproduction, a small number of siRNA loci are dramatically upregulated in the maternally-derived seed coat, suggesting that RdDM might have a special function during reproduction. However, the developmental consequence of RdDM has been difficult to dissect because disruption of RdDM does not result in overt phenotypes in Arabidopsis (Arabidopsis thaliana), where the pathway has been most thoroughly studied...
November 21, 2023: Plant Physiology
https://read.qxmd.com/read/37982740/psychiatry-nurses-experiences-of-patient-initiated-brief-admission-from-inpatient-and-outpatient-perspectives-a-qualitative-exploratory-study
#19
JOURNAL ARTICLE
Timmy Lindgren, Josefine Westdahl, Sigrid Stjernswärd, Erika A Saliba-Gustafsson, Lena Flyckt, Nitya Jayaram-Lindström, Joachim Eckerström
Patient-initiated brief admission (PIBA) allows patients to decide when admission to psychiatric care is necessary. This may prevent long-term hospitalisation and promote patient participation. Research on psychiatric nurses' experiences with PIBA is lacking, therefore 11 nurses were interviewed and data analysed using content analysis. Prominent categories were: improved personal development for the patient, more equal nurse-patient relationship, rapid access to a safe environment and strengthened professional collaboration...
November 20, 2023: Issues in Mental Health Nursing
https://read.qxmd.com/read/37981921/diarrheal-woes-in-transplantation-from-real-world-settings-with-special-focus-on-clostridium-difficile-infection
#20
JOURNAL ARTICLE
Uday Yanamandra, Alka Khadwal, Setu Gupta, Timmy Thomas, Deepesh Lad, Neelam Taneja, Gaurav Prakash, Neelam Varma, Subhash Varma, Pankaj Malhotra
BACKGROUND: Diarrhea is the major cause of discomfort and morbidity of patients undergoing hematopoietic stem cell transplant (HSCT). The cause of diarrhea may be infective or non-infective. METHODS: This is a prospective single center observational study from North India conducted over a period of approximately 4 years among 105 patients who underwent HSCT (autologous-72, allogeneic-33). The objective of the study was to identify the overall incidence and characteristics of diarrhea in HSCT in the real world, to evaluate any differences among allogeneic or autologous transplants, incidence of C Difficile among diarrheal patients, and antimicrobial usage among these patients...
2023: Medical Journal, Armed Forces India
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