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https://www.readbyqxmd.com/read/29203125/vascular-access-outcomes-reported-in-maintenance-hemodialysis-trials-a-systematic-review
#1
Andrea K Viecelli, Emma O'Lone, Benedicte Sautenet, Jonathan C Craig, Allison Tong, Eric Chemla, Lai-Seong Hooi, Timmy Lee, Charmaine Lok, Kevan R Polkinghorne, Robert R Quinn, Tushar Vachharajani, Raymond Vanholder, Li Zuo, Ashley B Irish, Trevor A Mori, Elaine M Pascoe, David W Johnson, Carmel M Hawley
BACKGROUND: Many randomized controlled trials have been performed with the goal of improving outcomes related to hemodialysis vascular access. If the reported outcomes are relevant and measured consistently to allow comparison of interventions across trials, such trials can inform decision making. This study aimed to assess the scope and consistency of vascular access outcomes reported in contemporary hemodialysis trials. STUDY DESIGN: Systematic review. SETTING & POPULATION: Adults requiring maintenance hemodialysis...
December 1, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29190377/european-society-of-cardiology-cardiovascular-disease-statistics-2017
#2
Adam Timmis, Nick Townsend, Chris Gale, Rick Grobbee, Nikos Maniadakis, Marcus Flather, Elizabeth Wilkins, Lucy Wright, Rimke Vos, Jeroen Bax, Maxim Blum, Fausto Pinto, Panos Vardas
Aims: The European Society of Cardiology (ESC) Atlas has been compiled by the European Heart Agency to document cardiovascular disease (CVD) statistics of the 56 ESC member countries. A major aim of this 2017 data presentation has been to compare high-income and middle-income ESC member countries to identify inequalities in disease burden, outcomes, and service provision. Methods and results: The Atlas utilizes a variety of data sources, including the World Health Organization, the Institute for Health Metrics and Evaluation, and the World Bank to document risk factors, prevalence, and mortality of cardiovascular disease and national economic indicators...
November 27, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29187096/survey-of-living-organ-donors-experience-and-directions-for-process-improvement
#3
Timmy Li, M Katherine Dokus, Kristin N Kelly, Nene Ugoeke, James R Rogers, George Asham, Venkatesh Abhishek Sharma, Dominic J Cirillo, Mary K Robinson, Erika K Venniro, Jeremy G Taylor, Mark S Orloff, Scott McIntosh, Randeep Kashyap
INTRODUCTION: Understanding living organ donors' experience with donation and challenges faced during the process is necessary to guide the development of effective strategies to maximize donor benefit and increase the number of living donors. METHODS: An anonymous self-administered survey, specifically designed for this population based on key informant interviews, was mailed to 426 individuals who donated a kidney or liver at our institution. Quantitative and qualitative methods including open and axial coding were used to analyze donor responses...
September 2017: Progress in Transplantation
https://www.readbyqxmd.com/read/29177406/cardiovascular-disease-statistics-from-the-european-atlas-inequalities-between-high-and-middle-income-member-countries-of-the-esc
#4
A Timmis, C P Gale, M Flather, N Maniadakis, P Vardas
No abstract text is available yet for this article.
November 21, 2017: European Heart Journal. Quality of Care & Clinical Outcomes
https://www.readbyqxmd.com/read/29177073/the-anticipatory-stress-response-to-sport-competition-a-systematic-review-with-meta-analysis-of-cortisol-reactivity
#5
Kjell N van Paridon, Matthew A Timmis, Charlotte M Nevison, Matt Bristow
Objective: Athletes anticipating sport competition regularly experience distinct emotional and physiological responses as a result of the expected psychosocial and physical stress. Specifically, cortisol, an indicator of hypothalamic-pituitary-adrenal axis activation, prepares the athlete for the psychological and physiological demands of competition. The objective of this meta-analysis is to analyse the magnitude of the anticipatory cortisol response in athletes preparing to participate in sport competition and to examine the influence of gender, level of competition and data collection time...
2017: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/29155472/experimental-reconstruction-of-double-strand-break-repair-mediated-plastid-dna-insertion-into-the-tobacco-nucleus
#6
Dong Wang, Jinbao Gu, Rakesh David, Zhen Wang, Songtao Yang, Iain R Searle, Jian-Kang Zhu, Jeremy N Timmis
The mitochondria and plastids of eukaryotic cells evolved from endosymbiotic prokaryotes. DNA from the endosymbionts has bombarded nuclei since the ancestral prokaryotes were engulfed by a precursor of the nucleated eukaryotic host. An experimental confirmation regarding the molecular mechanisms responsible for organelle DNA incorporation into nuclei has not been performed until the present analysis. Here we introduced double-strand DNA breaks into the nuclear genome of tobacco through inducible expression of I-SceI, and showed experimentally that tobacco chloroplast DNAs insert into nuclear genomes through double-strand DNA break repair...
November 20, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29132073/evaluation-of-a-text-message-based-maintenance-intervention-for-major-depressive-disorder-after-inpatient-cognitive-behavioral-therapy
#7
Sandra Schlicker, David D Ebert, Thomas Middendorf, Ingrid Titzler, Matthias Berking
INTRODUCTION: High relapse rates in Major Depressive Disorder (MDD) indicate the need for interventions enhancing the sustainability of treatment outcomes. Primary aim of the present study was to evaluate the effectiveness of a text-message-based maintenance intervention for depression (TMMI-D). Additionally, we aimed to clarify whether the use of individualized messages would lead to better outcome than the use of standardized messages which focused upon adaptive ways of regulating undesired emotions...
October 29, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29063739/microbial-biotechnology-is-10
#8
EDITORIAL
Kenneth Timmis, Joan Timmis
No abstract text is available yet for this article.
November 2017: Microbial Biotechnology
https://www.readbyqxmd.com/read/29045628/troponin-measurement-in-patients-with-suspected-acute-coronary-syndromes-walking-beyond-the-wall
#9
Paul Collinson, Adam Timmis
No abstract text is available yet for this article.
September 22, 2017: European Heart Journal. Quality of Care & Clinical Outcomes
https://www.readbyqxmd.com/read/29045585/multimorbidity-in-heart-failure-patients
#10
Simon Woldman, Adam Timmis
No abstract text is available yet for this article.
September 25, 2017: European Heart Journal. Quality of Care & Clinical Outcomes
https://www.readbyqxmd.com/read/29043965/japanese-encephalitis-virus-transmitted-via-blood-transfusion-hong-kong-china
#11
Vincent C C Cheng, Siddharth Sridhar, Shuk-Ching Wong, Sally C Y Wong, Jasper F W Chan, Cyril C Y Yip, Chi-Hung Chau, Timmy W K Au, Yu-Yan Hwang, Carol S W Yau, Janice Y C Lo, Cheuk-Kwong Lee, Kwok-Yung Yuen
Japanese encephalitis virus (JEV) is a mosquitoborne virus endemic to China and Southeast Asia that causes severe encephalitis in <1% of infected persons. Transmission of JEV via blood transfusion has not been reported. We report transmission of JEV via blood donation products from an asymptomatic viremic donor to 2 immunocompromised recipients. One recipient on high-dose immunosuppressive drugs received JEV-positive packed red blood cells after a double lung transplant; severe encephalitis and a poor clinical outcome resulted...
January 15, 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28973321/visual-search-behavior-in-individuals-with-retinitis-pigmentosa-during-level-walking-and-obstacle-crossing
#12
Matthew A Timmis, Jon Allsop, Mohammad Baranian, James Baker, Itay Basevitch, Keziah Latham, Shahina Pardhan, Kjell N van Paridon
Purpose: Investigate the visual search strategy of individuals with retinitis pigmentosa (RP) when negotiating a floor-based obstacle compared with level walking, and compared with those with normal vision. Methods: Wearing a mobile eye tracker, individuals with RP and normal vision walked along a level walkway or walked along the walkway negotiating a floor-based obstacle. In the level walking condition, tape was placed on the floor to act as an object attracting visual attention...
September 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28967232/microbiome-yarns-microbiome-basis-of-memory
#13
EDITORIAL
Kenneth Timmis, Franziska Jebok, Gabriella Molinari, Manfred Rohde, James Kenneth Timmis
No abstract text is available yet for this article.
November 2017: Microbial Biotechnology
https://www.readbyqxmd.com/read/28938706/ehj-quality-of-care-and-clinical-outcomes-now-recommended-for-medline-listing
#14
Adam Timmis
No abstract text is available yet for this article.
May 1, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28929818/improving-accountability-in-vaccine-decision-making
#15
James Kenneth Timmis, Steven Black, Rino Rappuoli
Healthcare decisions, in particular those affecting entire populations, should be evidence-based and taken by decision-makers sharing broad alignment with affected stakeholders. However, criteria, priorities and procedures for decision-making are sometimes non-transparent, frequently vary considerably across equivalent decision-bodies, do not always consider the broader benefits of new health-measures, and therefore do not necessarily adequately represent the relevant stakeholder-spectrum. Areas covered: To address these issues in the context of the evaluation of new vaccines, we have proposed a first baseline set of core evaluation criteria, primarily selected by members of the vaccine research community, and suggested their implementation in vaccine evaluation procedures...
November 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28874933/head-ct-for-minor-head-injury-presenting-to-the-emergency-department-in-the-era-of-choosing-wisely
#16
John DeAngelis, Valerie Lou, Timmy Li, Henry Tran, Praneeta Bremjit, Molly McCann, Peter Crane, Courtney M C Jones
INTRODUCTION: The Choosing Wisely campaign currently recommends avoiding computed tomography (CT) of the head in low-risk emergency department (ED) patients with minor head injury, based on validated decision rules. However, the degree of adherence to this guideline in clinical practice is unknown. The objective of this study was to evaluate adherence to the Choosing Wisely campaign's recommendations regarding head CT imaging of patients with minor head injury in the ED. METHODS: We conducted a retrospective cohort study of adult ED patients at a Level I trauma center...
August 2017: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28868756/the-contribution-of-microbial-biotechnology-to-economic-growth-and-employment-creation
#17
Kenneth Timmis, Victor de Lorenzo, Willy Verstraete, Juan Luis Ramos, Antoine Danchin, Harald Brüssow, Brajesh K Singh, James Kenneth Timmis
Our communication discusses the profound impact of bio-based economies - in particular microbial biotechnologies - on SDG 8: Promote sustained, inclusive and sustainable economic growth, full and productive employment and decent work for all. A bio-based economy provides significant potential for improving labour supply, education and investment, and thereby for substantially increasing the demographic dividend. This, in turn, improves the sustainable development of economies.
September 2017: Microbial Biotechnology
https://www.readbyqxmd.com/read/28857512/protein-complex-formation-during-denitrification-by-pseudomonas-aeruginosa
#18
REVIEW
José Manuel Borrero-de Acuña, Kenneth N Timmis, Martina Jahn, Dieter Jahn
The most efficient means of generating cellular energy is through aerobic respiration. Under anaerobic conditions, several prokaryotes can replace oxygen by nitrate as final electron acceptor. During denitrification, nitrate is reduced via nitrite, NO and N2 O to molecular nitrogen (N2 ) by four membrane-localized reductases with the simultaneous formation of an ion gradient for ATP synthesis. These four multisubunit enzyme complexes are coupled in four electron transport chains to electron donating primary dehydrogenases and intermediate electron transfer proteins...
November 2017: Microbial Biotechnology
https://www.readbyqxmd.com/read/28844992/diagnostic-and-prognostic-benefits-of-computed-tomography-coronary-angiography-using-the-2016-national-institute-for-health-and-care-excellence-guidance-within-a-randomised-trial
#19
Philip D Adamson, Amanda Hunter, Michelle C Williams, Anoop Sv Shah, David A McAllister, Tania A Pawade, Marc R Dweck, Nicholas L Mills, Colin Berry, Nicholas A Boon, Elizabeth Clark, Marcus Flather, John Forbes, Scott McLean, Giles Roditi, Edwin Jr van Beek, Adam D Timmis, David E Newby
OBJECTIVES: To evaluate the diagnostic and prognostic benefits of CT coronary angiography (CTCA) using the 2016 National Institute for Health and Care Excellence (NICE) guidelines for the assessment of suspected stable angina. METHODS: Post hoc analysis of the Scottish COmputed Tomography of the HEART (SCOT-HEART) trial of 4146 participants with suspected angina randomised to CTCA. Patients were dichotomised into NICE guideline-defined possible angina and non-anginal presentations...
August 27, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28840974/the-contribution-of-microbial-biotechnology-to-sustainable-development-goals
#20
Kenneth Timmis, Willem M de Vos, Juan Luis Ramos, Siegfried E Vlaeminck, Auxiliadora Prieto, Antoine Danchin, Willy Verstraete, Victor de Lorenzo, Sang Yup Lee, Harald Brüssow, James Kenneth Timmis, Brajesh K Singh
The signature and almost unique characteristic of microbial technology is the exceptional diversity of applications it can address, and the exceptional range of human activities and needs to which it is and can be applied. Precisely because sustainability goals have very diverse and complex components and requirements, microbial technology has the ability to contribute substantively on many levels in many arenas to global efforts to achieve sustainability. Indeed, microbial technology could be viewed as a unifying element in our progress towards sustainability...
September 2017: Microbial Biotechnology
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