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https://www.readbyqxmd.com/read/28427156/the-effects-of-dleu1-gene-expression-in-burkitt-lymphoma-bl-potential-mechanism-of-chemoimmunotherapy-resistance-in-bl
#1
Sanghoon Lee, Wen Luo, Tishi Shah, Changhong Yin, Timmy O'Connell, Tae-Hoon Chung, Sherrie L Perkins, Rodney R Miles, Janet Ayello, Erin Morris, Lauren Harrison, Carmella van de Ven, Mitchell S Cairo
Following a multivariant analysis we demonstrated that children and adolescents with Burkitt lymphoma (BL) and a 13q14.3 deletion have a significant decrease in event free survival (EFS) despite identical short intensive multi-agent chemotherapy. However, how this deletion in the 13q14.3 region is associated with a significant decrease in EFS in children and adolescents with BL is largely unknown. The gene Deleted in Lymphocytic Leukemia 1 (DLEU1) is located in the region of 13q14.3. Here, we report that DLEU1 expression is implicated in the regulation of BL programmed cell death, cell proliferation, and expression of apoptotic genes in transcription activator-like effector nuclease (TALEN)s-induced DLEU1 knockdown and DLEU1 overexpressing BL cell lines...
February 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28423765/evaluation-of-machine-learning-methods-to-predict-coronary-artery-disease-using-metabolomic-data
#2
Henrietta Forssen, Riyaz Patel, Natalie Fitzpatrick, Aroon Hingorani, Adam Timmis, Harry Hemingway, Spiros Denaxas
Metabolomic data can potentially enable accurate, non-invasive and low-cost prediction of coronary artery disease. Regression-based analytical approaches however might fail to fully account for interactions between metabolites, rely on a priori selected input features and thus might suffer from poorer accuracy. Supervised machine learning methods can potentially be used in order to fully exploit the dimensionality and richness of the data. In this paper, we systematically implement and evaluate a set of supervised learning methods (L1 regression, random forest classifier) and compare them to traditional regression-based approaches for disease prediction using metabolomic data...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28407446/doping-control-study-of-aicar-in-postrace-urine-and-plasma-samples-from-horses
#3
Jenny K Y Wong, Wai Him Kwok, George H M Chan, Timmy L S Choi, Emmie N M Ho, Murielle Jaubert, Ludovic Bailly-Chouriberry, Yves Bonnaire, Adam Cawley, H Ming Williams, John Keledjian, Lydia Brooks, Adam Chambers, Yuanyuan Lin, Terence S M Wan
Acadesine, 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside, commonly known as AICAR, is a naturally occurring adenosine monophosphate-activated protein kinase (AMPK) activator in many mammals including humans and horses. AICAR has attracted considerable attention recently in the field of doping control due to a study showing enhancement of endurance performance in unexercised or untrained mice, resulting in the term "exercise pill". Its use has been classified as gene doping by the World Anti-Doping Agency (WADA), and since it is endogenous, it may only be possible to control deliberate administration of AICAR to racehorses after establishment of an appropriate threshold...
April 13, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28401736/microbiome-yarns-microbiomology-of-winter-rosy-face
#4
EDITORIAL
Kenneth Timmis, Franziska Jebok
No abstract text is available yet for this article.
April 12, 2017: Microbial Biotechnology
https://www.readbyqxmd.com/read/28393591/presentation-management-and-mortality-after-a-first-mi-in-people-with-and-without-asthma-a-study-using-uk-minap-data
#5
Paulo Pinto, Kieran J Rothnie, Kelvin Lui, Adam Timmis, Liam Smeeth, Jennifer K Quint
Asthma has been associated with a higher incidence of myocardial infarction (MI), higher prevalence of MI risk factors and higher burden of cardiovascular diseases. However, detailed associations between the presentation and initial management at the time of MI and post-MI outcomes in people with asthma compared to the general population have not been studied. A total of 300,161 people were identified with a first MI over the period 2003-2013 in the Myocardial Ischaemia National Audit Project database, of whom 8922 (3%) had asthma...
January 1, 2017: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/28379388/prevalence-of-obstructive-coronary-artery-disease-and-prognosis-in-patients-with-stable-symptoms-and-a-zero-coronary-calcium-score
#6
Tarun K Mittal, Alison Pottle, Ed Nicol, Mahmoud Barbir, Ben Ariff, Saeed Mirsadraee, Michael Dubowitz, Diana A Gorog, Piers Clifford, Soroosh Firoozan, Robert Smith, Simon Dubrey, Harmeet Chana, Jaymin Shah, Nigel Stephens, Christopher Travill, Andrew Kelion, Mini Pakkal, Adam Timmis
Aims: CT calcium scoring (CTCS) and CT cardiac angiography (CTCA) are widely used in patients with stable chest pain to exclude significant coronary artery disease (CAD). We aimed to resolve uncertainty about the prevalence of obstructive coronary artery disease and long-term outcomes in patients with a zero-calcium score (ZCS). Methods and results: Consecutive patients with stable cardiac symptoms referred for CTCS or CTCS and CTCA from chest pain clinics to a tertiary cardiothoracic centre were prospectively enrolled...
March 31, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28373173/prognosis-of-undiagnosed-chest-pain-linked-electronic-health-record-cohort-study
#7
MULTICENTER STUDY
Kelvin P Jordan, Adam Timmis, Peter Croft, Danielle A van der Windt, Spiros Denaxas, Arturo González-Izquierdo, Richard A Hayward, Pablo Perel, Harry Hemingway
Objective To ascertain long term cardiovascular outcomes in patients whose chest pain remained undiagnosed six months after first presentation.Design Cohort study.Setting UK electronic health record database (CALIBER) linking primary care, secondary care, coronary registry, and death registry information.Participants 172 180 adults aged ≥18 from 223 general practices presenting with a first episode of recorded chest pain, classified from medical records as diagnosed (non-coronary condition or angina) or undiagnosed (cause unattributed) at first consultation between 2002 and 2009 and with no previous record of cardiovascular disease...
April 3, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28367760/methodological-challenges-in-studies-comparing-prehospital-advanced-life-support-with-basic-life-support
#8
Timmy Li, Courtney M C Jones, Manish N Shah, Jeremy T Cushman, Todd A Jusko
Determining the most appropriate level of care for patients in the prehospital setting during medical emergencies is essential. A large body of literature suggests that, compared with Basic Life Support (BLS) care, Advanced Life Support (ALS) care is not associated with increased patient survival or decreased mortality. The purpose of this special report is to synthesize the literature to identify common study design and analytic challenges in research studies that examine the effect of ALS, compared to BLS, on patient outcomes...
April 3, 2017: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/28329300/personalising-the-decision-for-prolonged-dual-antiplatelet-therapy-development-validation-and-potential-impact-of-prognostic-models-for-cardiovascular-events-and-bleeding-in-myocardial-infarction-survivors
#9
Laura Pasea, Sheng-Chia Chung, Mar Pujades-Rodriguez, Alireza Moayyeri, Spiros Denaxas, Keith A A Fox, Lars Wallentin, Stuart J Pocock, Adam Timmis, Amitava Banerjee, Riyaz Patel, Harry Hemingway
Aims: The aim of this study is to develop models to aid the decision to prolong dual antiplatelet therapy (DAPT) that requires balancing an individual patient's potential benefits and harms. Methods and results: Using population-based electronic health records (EHRs) (CALIBER, England, 2000-10), of patients evaluated 1 year after acute myocardial infarction (MI), we developed (n = 12 694 patients) and validated (n = 5613) prognostic models for cardiovascular (cardiovascular death, MI or stroke) events and three different bleeding endpoints...
February 27, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28329279/performance-of-hospitals-according-to-the-esc-acca-quality-indicators-and-30-day-mortality-for-acute-myocardial-infarction-national-cohort-study-using-the-united-kingdom-myocardial-ischaemia-national-audit-project-minap-register
#10
Owen Bebb, Marlous Hall, Keith A A Fox, Tatendashe B Dondo, Adam Timmis, Hector Bueno, François Schiele, Chris P Gale
Aims: To investigate the application of the European Society of Cardiology Acute Cardiovascular Care Association quality indicators (QI) for acute myocardial infarction for the study of hospital performance and 30-day mortality. Methods and results: National cohort study (n = 118,075 patients, n = 211 hospitals, MINAP registry), 2012-13. Overall, 16 of the 20 QIs could be calculated. Eleven QIs had a significant inverse association with GRACE risk adjusted 30-day mortality (all P < 0...
April 1, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28320707/total-center-percutaneous-coronary-intervention-volume-and-30-day-mortality-a-contemporary-national-cohort-study-of-427%C3%A2-467-elective-urgent-and-emergency-cases
#11
Darragh O'Neill, Owen Nicholas, Chris P Gale, Peter Ludman, Mark A de Belder, Adam Timmis, Keith A A Fox, Iain A Simpson, Simon Redwood, Simon G Ray
BACKGROUND: The relationship between procedural volume and prognosis after percutaneous coronary intervention (PCI) remains uncertain, with some studies finding in favor of an inverse association and some against. This UK study provides a contemporary reassessment in one of the few countries in the world with a nationally representative PCI registry. METHODS AND RESULTS: A nationwide cohort study was performed using the national British Cardiovascular Intervention Society registry...
March 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/28320412/high-resolution-hemodynamic-profiling-of-murine-arteriovenous-fistula-using-magnetic-resonance-imaging-and-computational-fluid-dynamics
#12
Daniel Pike, Yan-Ting Shiu, Maheshika Somarathna, Lingling Guo, Tatyana Isayeva, John Totenhagen, Timmy Lee
BACKGROUND: Arteriovenous fistula (AVF) maturation failure remains a major cause of morbidity and mortality in hemodialysis patients. The two major etiologies of AVF maturation failure are early neointimal hyperplasia development and persistent inadequate outward remodeling. Although hemodynamic changes following AVF creation may impact AVF remodeling and contribute to neointimal hyperplasia development and impaired outward remodeling, detailed AVF hemodynamics are not yet fully known...
March 20, 2017: Theoretical Biology & Medical Modelling
https://www.readbyqxmd.com/read/28314806/the-use-of-a-multidimensional-measure-of-dialysis-adequacy-moving-beyond-small-solute-kinetics
#13
REVIEW
Jeffrey Perl, Laura M Dember, Joanne M Bargman, Teri Browne, David M Charytan, Jennifer E Flythe, LaTonya J Hickson, Adriana M Hung, Michel Jadoul, Timmy Chang Lee, Klemens B Meyer, Hamid Moradi, Tariq Shafi, Isaac Teitelbaum, Leslie P Wong, Christopher T Chan
Urea removal has become a key measure of the intensity of dialysis treatment for kidney failure. Small solute removal, exemplified by Kt/Vurea, has been broadly applied as a means to quantify the dose of thrice weekly hemodialysis. Yet, the reliance on small solute clearances alone as a measure of dialysis adequacy fails fully to quantify the intended clinical effects of dialysis therapy. This review aims to (1) understand the strengths and limitations of small solute kinetics as a surrogate marker of dialysis dose, and (2) present the prospect of a more comprehensive construct for dialysis dose, one that considers more broadly the goals of ESRD care to maximize both quality of life and survival...
March 17, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28314523/detection-of-anabolic-and-androgenic-steroids-and-or-their-esters-in-horse-hair-using-ultra-high-performance-liquid-chromatography-high-resolution-mass-spectrometry
#14
Karen Y Kwok, Timmy L S Choi, Wai Him Kwok, Jenny K Y Wong, Terence S M Wan
Anabolic and androgenic steroids (AASs) are a class of prohibited substances banned in horseracing at all times. The common approach for controlling the misuse of AASs in equine sports is by detecting the presence of AASs and/or their metabolites in urine and blood samples using gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS). This approach, however, often falls short as the duration of effect for many AASs are longer than their detection time in both urine and blood...
April 14, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28282488/a-comparison-of-reach-to-grasp-and-transport-to-place-performance-in-participants-with-age-related-macular-degeneration-and-glaucoma
#15
Shahina Pardhan, Amy Scarfe, Rupert Bourne, Matthew Timmis
Purpose: To compare visually guided manual prehension in participants with primarily central field loss (CFL) due to age-related macular degeneration and peripheral visual field loss (PFL) due to glaucoma. This study extends current literature by comparing directly "reach-to-grasp" performance, and presents a new task of "transport-to-place" the object accurately to a new location. Data were compared to age-matched controls. Methods: Three-dimensional motion data were collected from 17 glaucoma participants with PFL, 17 participants with age-related macular degeneration CFL and 10 age-matched control participants...
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28246175/symptoms-and-quality-of-life-in-patients-with-suspected-angina-undergoing-ct-coronary-angiography-a-randomised-controlled-trial
#16
Michelle C Williams, Amanda Hunter, Anoop Shah, Valentina Assi, Stephanie Lewis, Kenneth Mangion, Colin Berry, Nicholas A Boon, Elizabeth Clark, Marcus Flather, John Forbes, Scott McLean, Giles Roditi, Edwin Jr van Beek, Adam D Timmis, David E Newby
BACKGROUND: In patients with suspected angina pectoris, CT coronary angiography (CTCA) clarifies the diagnosis, directs appropriate investigations and therapies, and reduces clinical events. The effect on patient symptoms is currently unknown. METHODS: In a prospective open-label parallel group multicentre randomised controlled trial, 4146 patients with suspected angina due to coronary heart disease were randomised 1:1 to receive standard care or standard care plus CTCA...
February 28, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28244275/microbiome-yarns-microbiomology-of-curly-and-straight-hair
#17
EDITORIAL
Kenneth Timmis, Franziska Jebok, Fabio Rigat, Willem M de Vos, James Kenneth Timmis
No abstract text is available yet for this article.
March 2017: Microbial Biotechnology
https://www.readbyqxmd.com/read/28215405/screening-of-over-100-drugs-in-horse-urine-using-automated-on-line-solid-phase-extraction-coupled-to-liquid-chromatography-high-resolution-mass-spectrometry-for-doping-control
#18
W H Kwok, Timmy L S Choi, Yeuki Y K Tsoi, Gary N W Leung, Terence S M Wan
A fast method for the direct analysis of enzyme-hydrolysed horse urine using an automated on-line solid-phase extraction (SPE) coupled to a liquid-chromatography/high resolution mass spectrometer was developed. Over 100 drugs of diverse drug classes could be simultaneously detected in horse urine at sub to low parts per billion levels. Urine sample was first hydrolysed by β-glucuronidase to release conjugated drugs, followed by centrifugal filtration. The filtrate (1mL) was directly injected into an on-line SPE system consisting of a pre-column filter and a SPE cartridge column for the separation of analytes from matrix components...
March 24, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28194620/mathematical-modeling-of-learning-from-an-inconsistent-source-a-nonlinear-approach
#19
Timmy Ma, Natalia L Komarova
Continuing the discussion of how children can modify and regularize linguistic inputs from adults, we present a new interpretation of existing algorithms to model and investigate the process of a learner learning from an inconsistent source. On the basis of this approach is a (possibly nonlinear) function (the update function) that relates the current state of the learner with an increment that it receives upon processing the source's input, in a sequence of updates. The model can be considered a nonlinear generalization of the classic Bush-Mosteller algorithm...
February 13, 2017: Bulletin of Mathematical Biology
https://www.readbyqxmd.com/read/28190410/the-effect-of-older-age-on-ems-use-for-transportation-to-an-emergency-department
#20
Courtney M C Jones, Erin B Wasserman, Timmy Li, Ashley Amidon, Marissa Abbott, Manish N Shah
Introduction Previous studies have found that older adults are more likely to use Emergency Medical Services (EMS) than younger adults, but the reasons for this remain understudied. Hypothesis/Problem This study aimed to determine if older age is associated with using EMS for transportation to an emergency department (ED) after controlling for confounding variables. METHODS: A cross-sectional survey study was conducted at a large academic medical center. Data on previous medical history, chief complaint, self-perceived illness severity, demographic information, and mode of arrival to the ED were collected on all subjects...
February 13, 2017: Prehospital and Disaster Medicine
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