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https://www.readbyqxmd.com/read/28078099/aligning-the-planets-the-role-of-nurses-in-the-care-of-patients-with-non-st-elevation-myocardial-infarction
#1
Christi Deaton, Rachel Johnson, Maggie Evans, Adam Timmis, Justin Zaman, Harry Hemingway, Jacqueline Hughes, Gene Feder, Helen Cramer
BACKGROUND: Studies have shown variation in care for patients with non-ST elevation myocardial infarction (NSTEMI), including in the roles of specialist and advanced practice nurses in diagnosis, treatment and coordination of care. AIM: The aim of this study was to describe the roles and responsibilities of specialist and advanced practice nurses in providing care for patients with NSTEMI. METHODS: Secondary analysis of observational field notes and interviews from an ethnographic study of variation in care for NSTEMI patients in 10 UK hospitals conducted 2011-2012...
January 2017: Nursing Open
https://www.readbyqxmd.com/read/28054457/doping-control-analysis-of-lithium-in-horse-urine-and-plasma-by-inductively-coupled-plasma-mass-spectrometry
#2
Timmy L S Choi, Jenny K Y Wong, Emmie N M Ho, Wai Him Kwok, Gary N W Leung, Peter Curl, Terence S M Wan
Lithium salts are commonly prescribed to treat bipolar disorder in humans. They are effective for the treatment of acute mania and the prophylaxis of manic relapses through long-term use. Although there is no reported legitimate therapeutic use of lithium in horses, its potential mood stabilizing effect, low cost and being readily available make lithium salt a potential agent of abuse in equine sports, especially for equestrian competition horses. Lithium can be found in soil, plants and water, as such it is naturally present in the equine body, thus a threshold is necessary to control its misuse in horses...
January 5, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28033161/relative-difficulties-of-daily-living-tasks-with-retinitis-pigmentosa
#3
Keziah Latham, Mohammad Baranian, Matthew A Timmis, Andy Fisher, Shahina Pardhan
PURPOSE: To determine the relative difficulty of activity of daily living tasks for people with retinitis pigmentosa (RP). METHODS: Participants with RP (n = 166) rated the difficulty of tasks (n = 43) underpinning the Dutch Activity Inventory goals of mobility indoors and outdoors, shopping, and using public transport. Demographic characteristics were also determined. Responses were Rasch analyzed to determine properties of the scale, derive unidimensional subscales, and consider differential item functioning (DIF)...
December 29, 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28017445/core-values-for-vaccine-evaluation
#4
James Kenneth Timmis, Fabio Rigat, Rino Rappuoli
Currently, most health economic modelling approaches tend to inadequately incorporate crucial disease-specific criteria and other attributes of benefit resulting from vaccination, which limits their utility for evaluating vaccines and, in consequence, for optimally guiding vaccine decision-making. Additionally, vaccine evaluation methods are frequently poorly standardised and non-transparent, leading to a potentially low level of accountability that can hinder acceptance of resulting decisions. To address these issues, we have considered whether it is possible to identify a set of universal vaccine-disease considerations, which we have called Core Values...
December 22, 2016: Vaccine
https://www.readbyqxmd.com/read/28017438/the-role-of-vaccines-and-vaccine-decision-making-to-achieve-the-goals-of-the-grand-convergence-in-public-health
#5
David C Kaslow, Jorge Kalil, David Bloom, Gianluca Breghi, Anna Maria Colucci, Ennio De Gregorio, Guru Madhavan, Genevieve Meier, Richard Seabrook, Xiaoning Xu
On 17 and 18 July 2015, a meeting in Siena jointly sponsored by ADITEC and GlaxoSmithKline (GSK) was held to review the goals of the Global Health 2035 Grand Convergence, to discuss current vaccine evaluation methods, and to determine the feasibility of reaching consensus on an assessment framework for comprehensively and accurately capturing the full benefits of vaccines. Through lectures and workshops, participants reached a consensus that Multi-Criteria-Decision-Analysis is a method suited to systematically account for the many variables needed to evaluate the broad benefits of vaccination, which include not only health system savings, but also societal benefits, including benefits to the family and increased productivity...
December 22, 2016: Vaccine
https://www.readbyqxmd.com/read/27965882/trial-of-optimal-personalised-care-after-treatment-for-gynaecological-cancer-topcat-g-a-study-protocol-for-a-randomised-feasibility-trial
#6
Kirstie Pye, Nicola Totton, Nicholas Stuart, Rhiannon Whitaker, Val Morrison, Rhiannon Tudor Edwards, Seow Tien Yeo, Laura J Timmis, Caryl Butterworth, Liz Hall, Tekendra Rai, Zoe Hoare, Richard D Neal, Clare Wilkinson, Simon Leeson
BACKGROUND: Gynaecological cancers are diagnosed in over 1000 women in Wales every year. We estimate that this is costing the National Health Service (NHS) in excess of £1 million per annum for routine follow-up appointments alone. Follow-up care is not evidence-based, and there are no definitive guidelines from The National Institute for Health and Care Excellence (NICE) for the type of follow-up that should be delivered. Standard care is to provide a regular medical review of the patient in a hospital-based outpatient clinic for a minimum of 5 years...
2016: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/27936755/spontaneous-vesiculation-and-ph-induced-disassembly-of-a-lysosomotropic-detergent-impacts-on-lysosomotropism-and-lysosomal-delivery
#7
Ana M Villamil Giraldo, Timmy Fyrner, Stefan Wennmalm, Atul N Parikh, Karin Öllinger, Thomas Ederth
Lysosomotropic detergents (LDs) selectively rupture lysosomal membranes through mechanisms that have yet to be characterized. A consensus view, currently, holds that LDs, which are weakly basic, diffuse across cellular membranes as monomers in an uncharged state, and via protonation in the acidic lysosomal compartment, they become trapped, accumulate, and subsequently solubilize the membrane and induce lysosomal membrane permeabilization. Here we demonstrate that the lysosomotropic detergent O-methyl-serine dodecylamide hydrochloride (MSDH) spontaneously assembles into vesicles at, and above, cytosolic pH, and that the vesicles disassemble as the pH reaches 6...
December 20, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/27933457/pristine-but-metal-rich-r%C3%A3-o-sucio-dirty-river-is-dominated-by-gallionella-and-other-iron-sulfur-oxidizing-microbes
#8
Alejandro Arce-Rodríguez, Fernando Puente-Sánchez, Roberto Avendaño, Eduardo Libby, Leonardo Rojas, Juan Carlos Cambronero, Dietmar H Pieper, Kenneth N Timmis, Max Chavarría
Whether the extreme conditions of acidity and heavy metal pollution of streams and rivers originating in pyritic formations are caused primarily by mining activities or by natural activities of metal-oxidizing microbes living within the geological formations is a subject of considerable controversy. Most microbiological studies of such waters have so far focused on acid mine drainage sites, which are heavily human-impacted environments, so it has been problematic to eliminate the human factor in the question of the origin of the key metal compounds...
December 8, 2016: Extremophiles: Life Under Extreme Conditions
https://www.readbyqxmd.com/read/27910221/a-routine-check-up-at-the-digital-medical-centre
#9
Kenneth N Timmis, James K Timmis
No abstract text is available yet for this article.
December 1, 2016: Microbial Biotechnology
https://www.readbyqxmd.com/read/27897379/microbiomes-metabolic-errors-and-detection-of-performance-enhancing-drug-abuse-1-2
#10
Kenneth Timmis, James Kenneth Timmis
No abstract text is available yet for this article.
November 29, 2016: Environmental Microbiology Reports
https://www.readbyqxmd.com/read/27868380/crystal-ball-microbiomes-metabolic-errors-and-detection-of-performance-enhancing-drug-abuse
#11
(no author information available yet)
No abstract text is available yet for this article.
November 21, 2016: Environmental Microbiology Reports
https://www.readbyqxmd.com/read/27863172/building-confidence-in-quantitative-systems-pharmacology-models-an-engineer-s-guide-to-exploring-the-rationale-in-model-design-and-development
#12
J Timmis, K Alden, P Andrews, E Clark, A Nellis, B Naylor, M Coles, P Kaye
This tutorial promotes good practice for exploring the rationale of systems pharmacology models. A safety systems engineering inspired notation approach provides much needed rigour and transparency in development and application of models for therapeutic discovery and design of intervention strategies. Structured arguments over a model's development, underpinning biological knowledge, and analyses of model behaviours, are constructed to determine the confidence that a model is fit for the purpose for which it will be applied...
November 11, 2016: CPT: Pharmacometrics & Systems Pharmacology
https://www.readbyqxmd.com/read/27630181/predictors-of-initiation-for-predialysis-arteriovenous-fistula
#13
Alian Al-Balas, Timmy Lee, Carlton J Young, Jill Barker-Finkel, Michael Allon
BACKGROUND AND OBJECTIVES: The optimal timing of predialysis arteriovenous fistula surgery remains uncertain. We evaluated factors associated with hemodialysis initiation in patients undergoing predialysis arteriovenous fistula surgery and derived a model to predict future initiation of dialysis. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Our study retrospectively identified 308 patients undergoing predialysis arteriovenous fistula creation at a large medical center in 2006-2012 to determine whether they initiated hemodialysis...
September 14, 2016: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/27628175/automated-multi-objective-calibration-of-biological-agent-based-simulations
#14
Mark N Read, Kieran Alden, Louis M Rose, Jon Timmis
Computational agent-based simulation (ABS) is increasingly used to complement laboratory techniques in advancing our understanding of biological systems. Calibration, the identification of parameter values that align simulation with biological behaviours, becomes challenging as increasingly complex biological domains are simulated. Complex domains cannot be characterized by single metrics alone, rendering simulation calibration a fundamentally multi-metric optimization problem that typical calibration techniques cannot handle...
September 2016: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/27621836/international-guideline-changes-and-the-incidence-of-infective-endocarditis-a-systematic-review
#15
Omeair Khan, Ahmed Mohamed Abdel Shafi, Adam Timmis
The objective of this study was to determine the impact on incident infective endocarditis (IE) of guideline recommendations to restrict indications for antibiotic prophylaxis. We conducted a systematic review according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guideline. PubMed and EMBASE databases were searched for articles published between 2007 and 2015 using mesh terms relevant to the research question. Included were English language articles published after 2009 that provided estimates of IE incidence before-and-after major international guideline changes...
2016: Open Heart
https://www.readbyqxmd.com/read/27591036/orolingual-angioedema-to-alteplase-identify-counsel-and-monitor-at-risk-patients
#16
Christopher Timmis, Elliot Epstein, Mohmad Salim
Orolingual angioedema (OLA) is a known complication of intravenous alteplase used to treat ischaemic stroke. The incidence may be as high as 5.1%. ACE inhibitors are thought to increase the risk of developing this potentially life-threatening complication. This case report demonstrates how we may improve in the identification of risk factors in the history; the counselling of patients appropriately; in seeking alternative therapies such as mechanical thrombectomy; and in the monitoring of patients for signs of OLA once alteplase has been given...
September 2, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27589606/leukocyte-motility-models-assessed-through-simulation-and-multi-objective-optimization-based-model-selection
#17
Mark N Read, Jacqueline Bailey, Jon Timmis, Tatyana Chtanova
The advent of two-photon microscopy now reveals unprecedented, detailed spatio-temporal data on cellular motility and interactions in vivo. Understanding cellular motility patterns is key to gaining insight into the development and possible manipulation of the immune response. Computational simulation has become an established technique for understanding immune processes and evaluating hypotheses in the context of experimental data, and there is clear scope to integrate microscopy-informed motility dynamics...
September 2016: PLoS Computational Biology
https://www.readbyqxmd.com/read/27577241/association-of-peritonitis-with-hemodialysis-catheter-dependence-after-modality-switch
#18
Timmy Lee, Mae Thamer, Yi Zhang, Qian Zhang, Michael Allon
BACKGROUND AND OBJECTIVES: Few studies have evaluated vascular access use after transition from peritoneal dialysis to hemodialysis. Our study characterizes vascular access use after switch to hemodialysis and its effect on patient mortality and evaluates whether a peritonitis event preceding the switch was associated with the timing of permanent vascular access placement and use. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: The US Renal Data System data were used to evaluate the establishment of a permanent vascular access in 1165 incident Medicare-insured adult patients on dialysis who initiated peritoneal dialysis between July 1, 2010 and June 30, 2011 and switched to hemodialysis within 1 year...
November 7, 2016: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/27574717/association-of-clinical-factors-and-therapeutic-strategies-with-improvements-in-survival-following-non-st-elevation-myocardial-infarction-2003-2013
#19
Marlous Hall, Tatendashe B Dondo, Andrew T Yan, Shaun G Goodman, Héctor Bueno, Derek P Chew, David Brieger, Adam Timmis, Phillip D Batin, John E Deanfield, Harry Hemingway, Keith A A Fox, Christopher P Gale
IMPORTANCE: International studies report a decline in mortality following non-ST-elevation myocardial infarction (NSTEMI). Whether this is due to lower baseline risk or increased utilization of guideline-indicated treatments is unknown. OBJECTIVE: To determine whether changes in characteristics of patients with NSTEMI are associated with improvements in outcomes. DESIGN, SETTING, AND PARTICIPANTS: Data on patients with NSTEMI in 247 hospitals in England and Wales were obtained from the Myocardial Ischaemia National Audit Project between January 1, 2003, and June 30, 2013 (final follow-up, December 31, 2013)...
September 13, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27574334/quality-indicators-for-acute-myocardial-infarction-a-position-paper-of-the-acute-cardiovascular-care-association
#20
Francois Schiele, Chris P Gale, Eric Bonnefoy, Frederic Capuano, Marc J Claeys, Nicolas Danchin, Keith Aa Fox, Kurt Huber, Zaza Iakobishvili, Maddalena Lettino, Tom Quinn, Maria Rubini Gimenez, Hans E Bøtker, Eva Swahn, Adam Timmis, Marco Tubaro, Christiaan Vrints, David Walker, Doron Zahger, Uwe Zeymer, Hector Bueno
Evaluation of quality of care is an integral part of modern healthcare, and has become an indispensable tool for health authorities, the public, the press and patients. However, measuring quality of care is difficult, because it is a multifactorial and multidimensional concept that cannot be estimated solely on the basis of patients' clinical outcomes. Thus, measuring the process of care through quality indicators (QIs) has become a widely used practice in this context. Other professional societies have published QIs for the evaluation of quality of care in the context of acute myocardial infarction (AMI), but no such indicators exist in Europe...
August 29, 2016: European Heart Journal. Acute Cardiovascular Care
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