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https://www.readbyqxmd.com/read/29879718/acute-kidney-injury-before-dialysis-initiation-predicts-adverse-outcomes-in-hemodialysis-patients
#1
Timmy Lee, Silvi Shah, Anthony C Leonard, Pratik Parikh, Charuhas V Thakar
BACKGROUND: Acute kidney injury (AKI) is associated with increased morbidity and mortality. Mortality in end-stage renal disease (ESRD) patients is highest during the first year of dialysis. The impact of pre-ESRD AKI events on long-term outcomes in incident ESRD patients remains unknown. METHODS: We evaluated a retrospective cohort of 47,341 incident hemodialysis patients from the United States Renal Data System with linked Medicare data for at least 2 years prior to hemodialysis initiation...
June 7, 2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29875140/validity-of-inducible-ischaemia-as-a-surrogate-for-adverse-outcomes-in-stable-coronary-artery-disease
#2
Adam Timmis, Antony Raharja, R Andrew Archbold, Anthony Mathur
Regional myocardial ischaemia is commonly expressed as exertional angina in patients with stable coronary artery disease (CAD). It also associates with prognosis, risk tending to increase with the severity of ischaemia. The validity of myocardial ischaemia as a surrogate for adverse clinical outcomes, however, has not been well established. Thus, in cohort studies, ischaemia testing has failed to influence rates of myocardial infarction and coronary death. Moreover, in clinical studies, pharmacological and interventional treatments that are effective in correcting ischaemia have rarely been shown to reduce cardiovascular (CV) risk...
June 6, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29795676/wash-activities-at-two-ebola-treatment-units-in-sierra-leone
#3
Michaela Mallow, Lee Gary, Timmy Jeng, Bob Bongomin, Miriam Tamar Aschkenasy, Peter Wallis, Hilarie H Cranmer, Estifanos Debasu, Adam C Levine
PURPOSE: The 2014 outbreak of Ebola virus disease (EVD) in West Africa was the largest in history. Starting in September 2014, International Medical Corps (IMC) operated five Ebola treatment units (ETUs) in Sierra Leone and Liberia. This paper explores how future infectious disease outbreak facilities in resource-limited settings can be planned, organized, and managed by analyzing data collected on water, sanitation, and hygiene (WASH) and infection prevention control (IPC) protocols...
2018: PloS One
https://www.readbyqxmd.com/read/29784614/tradeoffs-in-vascular-access-selection-in-elderly-patients-initiating-hemodialysis-with-a-catheter
#4
Timmy Lee, Joyce Qian, Mae Thamer, Michael Allon
RATIONALE & OBJECTIVE: National vascular access guidelines recommend placement of arteriovenous fistulas (AVFs) over grafts (AVGs) in hemodialysis patients, but have not been comprehensively assessed in the elderly. We evaluated clinically relevant vascular access outcomes in elderly patients receiving an AVF or AVG after hemodialysis therapy initiation. STUDY DESIGN: Retrospective cohort study using national administrative data. SETTINGS & PARTCIPANTS: Claims data from the US Renal Data System of 9,458 US patients 67 years and older who initiated hemodialysis therapy from July 1, 2010, to June 30, 2011, with a catheter and received an AVF (n=7,433) or AVG (n=2,025) within the ensuing 6 months...
May 18, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29770574/microbiome-yarns-microbiome-of-the-built-environment-paranormal-microbiology-and-the-power-of-single-cell-genomics1-2-3-4
#5
EDITORIAL
Kenneth Timmis, Franziska Jebok, Manfred Rohde, Gabriella Molinari
No abstract text is available yet for this article.
May 16, 2018: Microbial Biotechnology
https://www.readbyqxmd.com/read/29767621/commentary-the-case-for-more-comprehensive-data-on-household-food-insecurity
#6
Valerie Tarasuk, Timmie Li, Andrew Mitchell, Naomi Dachner
No abstract text is available yet for this article.
May 2018: Health Promotion and Chronic Disease Prevention in Canada
https://www.readbyqxmd.com/read/29750400/environmental-microbiology-the-next-20-years-bioconnectivity-and-meta-omics-2-0
#7
EDITORIAL
Kenneth Timmis
No abstract text is available yet for this article.
May 11, 2018: Environmental Microbiology
https://www.readbyqxmd.com/read/29687066/acute-pustular-eruption-following-a-jarisch-herxheimer-reaction-in-the-treatment-of-syphilis
#8
Rachel L Giesey, Gregory R Delost, Timmie R Sharma, Kevin D Cooper
No abstract text is available yet for this article.
April 2018: JAAD Case Reports
https://www.readbyqxmd.com/read/29665351/neuroendocrine-response-to-gaba-b-receptor-agonism-in-alcohol-dependent-individuals-results-from-a-combined-outpatient-and-human-laboratory-experiment
#9
Mehdi Farokhnia, Mikela B Sheskier, Mary R Lee, April N Le, Erick Singley, Sofia Bouhlal, Timmy Ton, Zhen Zhao, Lorenzo Leggio
Gamma-aminobutyric acid (GABA), the main inhibitory neurotransmitter in the nervous system, plays an important role in biobehavioral processes that regulate alcohol seeking, food intake, and stress response. The metabotropic GABA-B receptor has been investigated as a potential therapeutic target for alcohol use disorder, by using orthosteric agonists (e.g., baclofen) and positive allosteric modulators. Whether and how pharmacological manipulation of the GABA-B receptor, in combination with alcohol intake, may affect feeding- and stress-related neuroendocrine pathways remains unknown...
April 14, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29602630/medicare-costs-associated-with-arteriovenous-fistulas-among-us-hemodialysis-patients
#10
Mae Thamer, Timmy C Lee, Haimanot Wasse, Marc H Glickman, Joyce Qian, Daniel Gottlieb, Scott Toner, Timothy A Pflederer
BACKGROUND: An arteriovenous fistula (AVF) is the recommended vascular access for hemodialysis (HD). Previous studies have not examined the resources and costs associated with creating and maintaining AVFs. STUDY DESIGN: Retrospective observational study. SETTING & PARTICIPANTS: Elderly US Medicare patients initiating hemodialysis therapy during 2010 to 2011. PREDICTOR: AVF primary and secondary patency and nonuse in the first year following AVF creation...
March 28, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29600100/unusual-cardiac-paraganglioma-mimicking-an-atypical-carcinoid-tumor-of-the-lung
#11
Dean Spencer, Mark Evans, Beverly Wang, J Lawrence Delrosario, Timmy Cheng, Jeffrey Milliken
We present a case of unusual cardiac paraganglioma (PG) initially misdiagnosed as atypical carcinoid tumor of the lung and discuss key clinical and pathologic characteristics that guide surgical management of these rare chromaffin cell tumors. A 64-year-old female with persistent cough and back pain was found to have a 4 cm × 3 cm mass abutting multiple cardiopulmonary structures. A biopsy was performed at an outside institution and pathology reported "atypical neuroendocrine carcinoma, consistent with carcinoid"...
January 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29569777/maternal-components-of-rna-directed-dna-methylation-are-required-for-seed-development-in-brassica-rapa
#12
Jeffrey W Grover, Timmy Kendall, Abdul Baten, Diane Burgess, Michael Freeling, Graham J King, Rebecca A Mosher
Small RNAs trigger repressive DNA methylation at thousands of transposable elements in a process called RNA-directed DNA methylation (RdDM). The molecular mechanism of RdDM is well characterized in Arabidopsis, yet the biological function remains unclear, as loss of RdDM in Arabidopsis causes no overt defects, even after generations of inbreeding. It is known that 24 nucleotide Pol IV-dependent siRNAs, the hallmark of RdDM, are abundant in flowers and developing seeds, indicating that RdDM might be important during reproduction...
May 2018: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29565998/two-key-cathepsins-tgcpb-and-tgcpl-are-targeted-by-the-vinyl-sulfone-inhibitor-k11777-in-in-vitro-and-in-vivo-models-of-toxoplasmosis
#13
Juan D Chaparro, Timmy Cheng, Uyen Phuong Tran, Rosa M Andrade, Sara B T Brenner, Grace Hwang, Shara Cohn, Ken Hirata, James H McKerrow, Sharon L Reed
Although toxoplasmosis is one of the most common parasitic infections worldwide, therapeutic options remain limited. Cathepsins, proteases that play key roles in the pathogenesis of toxoplasmosis and many other protozoan infections, are important potential therapeutic targets. Because both TgCPB and TgCPL play a role in T. gondii invasion, we evaluated the efficacy of the potent, irreversible vinyl sulfone inhibitor, K11777 (N-methyl-piperazine-Phe-homoPhe-vinylsulfone-phenyl). The inhibitor's toxicity and pharmacokinetic profile have been well-studied because of its in vitro and in vivo activity against a number of parasites...
2018: PloS One
https://www.readbyqxmd.com/read/29548567/metabolic-study-of-methylstenbolone-in-horses-using-liquid-chromatography-high-resolution-mass-spectrometry-and-gas-chromatography-mass-spectrometry
#14
Timmy L S Choi, Jenny K Y Wong, Wai Him Kwok, Peter Curl, Stewart Mechie, Terence S M Wan
Methylstenbolone (2,17α-dimethyl-5α-androst-1-en-17β-ol-3-one) is a synthetic anabolic and androgenic steroid (AAS) sold as an oral 'nutritional supplement' under the brand names 'Ultradrol', 'M-Sten' and 'Methyl-Sten'. Like other AASs, methylstenbolone is a prohibited substance in both human and equine sports. This paper describes the studies of the in vitro and in vivo metabolism of methylstenbolone in horses using LC/HRMS, GC/MS and GC/MS/MS. Phase I in vitro metabolic study of methylstenbolone was performed using homogenised horse liver...
April 20, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29540484/metabolomics-reveals-critical-adrenergic-regulatory-checkpoints-in-glycolysis-and-pentose-phosphate-pathways-in-embryonic-heart
#15
Jessica N R Peoples, Timmi Maxmillian, Quynh Le, Sergiy M Nadtochiy, Paul S Brookes, George A Porter, Victor L Davidson, Steven N Ebert
Cardiac energy demands during early embryonic periods are sufficiently met through glycolysis, but as development proceeds, the oxidative phosphorylation in mitochondria becomes increasingly vital. Adrenergic hormones are known to stimulate metabolism in adult mammals and are essential for embryonic development, but relatively little is known about their effects on metabolism in the embryonic heart. Here, we show that embryos lacking adrenergic stimulation have ∼10-fold less cardiac ATP compared with littermate controls...
May 4, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29523721/mrsa-nares-swab-is-a-more-accurate-predictor-of-mrsa-wound-infection-compared-with-clinical-risk-factors-in-emergency-department-patients-with-skin-and-soft-tissue-infections
#16
Nicole M Acquisto, Ryan P Bodkin, Jack E Brown, Paul S Graman, Courtney Marie Cora Jones, Timmy Li, Dwight J Hardy, Elizabeth Dodds Ashley
OBJECTIVES: Skin and soft tissue infections (SSTI) caused by methicillin-resistant Staphylococcus aureus (MRSA) are prevalent in the emergency department (ED). We determined whether MRSA nasal carriage better identifies patients with MRSA wound infection than clinical risk factors or emergency medicine (EM) provider's choice of discharge prescriptions. METHODS: Adult patients presenting to a large academic medical centre ED in the USA with SSTI between May 2010 and November 2011 were screened...
March 9, 2018: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29523565/feasibility-of-real-time-capture-of-routine-clinical-data-in-the-electronic-health-record-a-hospital-based-observational-service-evaluation-study
#17
Neil Bodagh, R Andrew Archbold, Roshan Weerackody, Meredith K D Hawking, Michael R Barnes, Aaron M Lee, Surjeet Janjuha, Charles Gutteridge, John Robson, Adam Timmis
OBJECTIVES: The electronic health record (EHR) is underused in the hospital setting. The aim of this service evaluation study was to respond to National Health Service (NHS) Digital's ambition for a paperless NHS by capturing routinely collected cardiac outpatient data in the EHR to populate summary patient reports and provide a resource for audit and research. DESIGN: A PowerForm template was developed within the Cerner EHR, for real-time entry of routine clinical data by clinicians attending a cardiac outpatient clinic...
March 8, 2018: BMJ Open
https://www.readbyqxmd.com/read/29509764/multimorbidity-and-survival-for-patients-with-acute-myocardial-infarction-in-england-and-wales-latent-class-analysis-of-a-nationwide-population-based-cohort
#18
Marlous Hall, Tatendashe B Dondo, Andrew T Yan, Mamas A Mamas, Adam D Timmis, John E Deanfield, Tomas Jernberg, Harry Hemingway, Keith A A Fox, Chris P Gale
BACKGROUND: There is limited knowledge of the scale and impact of multimorbidity for patients who have had an acute myocardial infarction (AMI). Therefore, this study aimed to determine the extent to which multimorbidity is associated with long-term survival following AMI. METHODS AND FINDINGS: This national observational study included 693,388 patients (median age 70.7 years, 452,896 [65.5%] male) from the Myocardial Ischaemia National Audit Project (England and Wales) who were admitted with AMI between 1 January 2003 and 30 June 2013...
March 2018: PLoS Medicine
https://www.readbyqxmd.com/read/29498538/weekend-effect-in-acute-coronary-syndrome-a-meta-analysis-of-observational-studies
#19
Chun Shing Kwok, Mohammed Al-Dokheal, Sami Aldaham, Claire Rushton, Rob Butler, Tim Kinnaird, Azfar Zaman, M Justin Zaman, Adam Timmis, Mamas A Mamas
BACKGROUND: The effect of a weekend compared with a weekday hospital admission on patient outcomes after an acute coronary syndrome is unclear. This study aims to determine whether collectively there is a weekend effect in acute coronary syndrome. METHOD: We conducted a systematic review and meta-analysis of cohort studies examining the association between weekend compared to weekday admission at any time of the day and early mortality (in-hospital or 30-day). A search was performed on Medline and Embase and relevant studies were pooled using random effects meta-analysis for risk of early mortality...
March 1, 2018: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/29493048/reduced-olfactory-bulb-volume-in-depression-a-structural-moderator-analysis
#20
Fabian Rottstädt, Pengfei Han, Kerstin Weidner, Julia Schellong, Sylvia Wolff-Stephan, Timmy Strauß, Hagen Kitzler, Thomas Hummel, Ilona Croy
BACKGROUND: Removal of the olfactory bulb (OB) leads to depression like behavior in rodents. A link between depression and olfactory function is also established in humans. We hypothesized that the human OB volume relates to depressive state and tested whether such a potential coherence is moderated by structural alterations in other brain regions. METHODS: Eighty-three participants (32 patients with major depression and 51 matched healthy controls) underwent structural MR scanning...
June 2018: Human Brain Mapping
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