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https://www.readbyqxmd.com/read/29045628/troponin-measurement-in-patients-with-suspected-acute-coronary-syndromes-walking-beyond-the-wall
#1
Paul Collinson, Adam Timmis
No abstract text is available yet for this article.
September 22, 2017: European Heart Journal. Quality of Care & Clinical Outcomes
https://www.readbyqxmd.com/read/29045585/multimorbidity-in-heart-failure-patients
#2
Simon Woldman, Adam Timmis
No abstract text is available yet for this article.
September 25, 2017: European Heart Journal. Quality of Care & Clinical Outcomes
https://www.readbyqxmd.com/read/29043965/japanese-encephalitis-virus-transmitted-via-blood-transfusion-hong-kong-china
#3
Vincent C C Cheng, Siddharth Sridhar, Shuk-Ching Wong, Sally C Y Wong, Jasper F W Chan, Cyril C Y Yip, Chi-Hung Chau, Timmy W K Au, Yu-Yan Hwang, Carol S W Yau, Janice Y C Lo, Cheuk-Kwong Lee, Kwok-Yung Yuen
Japanese encephalitis virus (JEV) is a mosquitoborne virus endemic to China and Southeast Asia that causes severe encephalitis in <1% of infected persons. Transmission of JEV via blood transfusion has not been reported. We report transmission of JEV via blood donation products from an asymptomatic viremic donor to 2 immunocompromised recipients. One recipient on high-dose immunosuppressive drugs received JEV-positive packed red blood cells after a double lung transplant; severe encephalitis and a poor clinical outcome resulted...
January 15, 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28973321/visual-search-behavior-in-individuals-with-retinitis-pigmentosa-during-level-walking-and-obstacle-crossing
#4
Matthew A Timmis, Jon Allsop, Mohammad Baranian, James Baker, Itay Basevitch, Keziah Latham, Shahina Pardhan, Kjell N van Paridon
Purpose: Investigate the visual search strategy of individuals with retinitis pigmentosa (RP) when negotiating a floor-based obstacle compared with level walking, and compared with those with normal vision. Methods: Wearing a mobile eye tracker, individuals with RP and normal vision walked along a level walkway or walked along the walkway negotiating a floor-based obstacle. In the level walking condition, tape was placed on the floor to act as an object attracting visual attention...
September 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28967232/microbiome-yarns-microbiome-basis-of-memory
#5
EDITORIAL
Kenneth Timmis, Franziska Jebok, Gabriella Molinari, Manfred Rohde, James Kenneth Timmis
No abstract text is available yet for this article.
October 2, 2017: Microbial Biotechnology
https://www.readbyqxmd.com/read/28938706/ehj-quality-of-care-and-clinical-outcomes-now-recommended-for-medline-listing
#6
Adam Timmis
No abstract text is available yet for this article.
May 1, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28929818/improving-accountability-in-vaccine-decision-making
#7
James Kenneth Timmis, Steven Black, Rino Rappuoli
Healthcare decisions, in particular those affecting entire populations, should be evidence-based and taken by decision-makers sharing broad alignment with affected stakeholders. However, criteria, priorities and procedures for decision-making are sometimes non-transparent, frequently vary considerably across equivalent decision-bodies, do not always consider the broader benefits of new health-measures, and therefore do not necessarily adequately represent the relevant stakeholder-spectrum. Areas covered: To address these issues in the context of the evaluation of new vaccines, we have proposed a first baseline set of core evaluation criteria, primarily selected by members of the vaccine research community, and suggested their implementation in vaccine evaluation procedures...
November 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28874933/head-ct-for-minor-head-injury-presenting-to-the-emergency-department-in-the-era-of-choosing-wisely
#8
John DeAngelis, Valerie Lou, Timmy Li, Henry Tran, Praneeta Bremjit, Molly McCann, Peter Crane, Courtney M C Jones
INTRODUCTION: The Choosing Wisely campaign currently recommends avoiding computed tomography (CT) of the head in low-risk emergency department (ED) patients with minor head injury, based on validated decision rules. However, the degree of adherence to this guideline in clinical practice is unknown. The objective of this study was to evaluate adherence to the Choosing Wisely campaign's recommendations regarding head CT imaging of patients with minor head injury in the ED. METHODS: We conducted a retrospective cohort study of adult ED patients at a Level I trauma center...
August 2017: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28868756/the-contribution-of-microbial-biotechnology-to-economic-growth-and-employment-creation
#9
Kenneth Timmis, Victor de Lorenzo, Willy Verstraete, Juan Luis Ramos, Antoine Danchin, Harald Brüssow, Brajesh K Singh, James Kenneth Timmis
Our communication discusses the profound impact of bio-based economies - in particular microbial biotechnologies - on SDG 8: Promote sustained, inclusive and sustainable economic growth, full and productive employment and decent work for all. A bio-based economy provides significant potential for improving labour supply, education and investment, and thereby for substantially increasing the demographic dividend. This, in turn, improves the sustainable development of economies.
September 2017: Microbial Biotechnology
https://www.readbyqxmd.com/read/28857512/protein-complex-formation-during-denitrification-by-pseudomonas-aeruginosa
#10
REVIEW
José Manuel Borrero-de Acuña, Kenneth N Timmis, Martina Jahn, Dieter Jahn
The most efficient means of generating cellular energy is through aerobic respiration. Under anaerobic conditions, several prokaryotes can replace oxygen by nitrate as final electron acceptor. During denitrification, nitrate is reduced via nitrite, NO and N2 O to molecular nitrogen (N2 ) by four membrane-localized reductases with the simultaneous formation of an ion gradient for ATP synthesis. These four multisubunit enzyme complexes are coupled in four electron transport chains to electron donating primary dehydrogenases and intermediate electron transfer proteins...
August 31, 2017: Microbial Biotechnology
https://www.readbyqxmd.com/read/28844992/diagnostic-and-prognostic-benefits-of-computed-tomography-coronary-angiography-using-the-2016-national-institute-for-health-and-care-excellence-guidance-within-a-randomised-trial
#11
Philip D Adamson, Amanda Hunter, Michelle C Williams, Anoop Sv Shah, David A McAllister, Tania A Pawade, Marc R Dweck, Nicholas L Mills, Colin Berry, Nicholas A Boon, Elizabeth Clark, Marcus Flather, John Forbes, Scott McLean, Giles Roditi, Edwin Jr van Beek, Adam D Timmis, David E Newby
OBJECTIVES: To evaluate the diagnostic and prognostic benefits of CT coronary angiography (CTCA) using the 2016 National Institute for Health and Care Excellence (NICE) guidelines for the assessment of suspected stable angina. METHODS: Post hoc analysis of the Scottish COmputed Tomography of the HEART (SCOT-HEART) trial of 4146 participants with suspected angina randomised to CTCA. Patients were dichotomised into NICE guideline-defined possible angina and non-anginal presentations...
August 27, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28840974/the-contribution-of-microbial-biotechnology-to-sustainable-development-goals
#12
Kenneth Timmis, Willem M de Vos, Juan Luis Ramos, Siegfried E Vlaeminck, Auxiliadora Prieto, Antoine Danchin, Willy Verstraete, Victor de Lorenzo, Sang Yup Lee, Harald Brüssow, James Kenneth Timmis, Brajesh K Singh
The signature and almost unique characteristic of microbial technology is the exceptional diversity of applications it can address, and the exceptional range of human activities and needs to which it is and can be applied. Precisely because sustainability goals have very diverse and complex components and requirements, microbial technology has the ability to contribute substantively on many levels in many arenas to global efforts to achieve sustainability. Indeed, microbial technology could be viewed as a unifying element in our progress towards sustainability...
September 2017: Microbial Biotechnology
https://www.readbyqxmd.com/read/28840966/the-diy-digital-medical-centre
#13
James Kenneth Timmis, Kenneth Timmis
Healthcare systems worldwide are confronted with major economic, organizational and logistical challenges. Historic evolution of health care has led to significant healthcare sector fragmentation, resulting in systemic inefficiencies and suboptimal resource exploitation. To attain a sustainable healthcare model, fundamental, system-wide improvements that effectively network, and ensure fulfilment of potential synergies between sectors, and include and facilitate coherent strategic planning and organisation of healthcare infrastructure are needed...
September 2017: Microbial Biotechnology
https://www.readbyqxmd.com/read/28812941/self-retaining-magnetic-implant-a-novel-design-of-orbital-prosthesis-for-the-exenterated-orbit
#14
Shiu Ting Mak, Timmy K C Chan, Kenneth K W Li
Orbital exenteration can lead to significant disfigurement causing considerable functional, cosmetic and psychological disturbances to the patient. Orbital prosthesis is important for the patient's cosmetic and psychological rehabilitation. A 49-year-old man received orbital exenteration and postoperative radiotherapy for malignant orbital carcinoma. In view of uncertain suitability and survival of osseointegrated implant in his case, a novel design of ocular implant consisting of a self-retaining magnetic spring retainer and a coupling silicone prosthesis was used...
August 16, 2017: Orbit
https://www.readbyqxmd.com/read/28806756/generic-scalable-and-decentralized-fault-detection-for-robot-swarms
#15
Danesh Tarapore, Anders Lyhne Christensen, Jon Timmis
Robot swarms are large-scale multirobot systems with decentralized control which means that each robot acts based only on local perception and on local coordination with neighboring robots. The decentralized approach to control confers number of potential benefits. In particular, inherent scalability and robustness are often highlighted as key distinguishing features of robot swarms compared with systems that rely on traditional approaches to multirobot coordination. It has, however, been shown that swarm robotics systems are not always fault tolerant...
2017: PloS One
https://www.readbyqxmd.com/read/28802342/improving-value-in-neonatal-intensive-care
#16
REVIEW
Timmy Ho, John A F Zupancic, DeWayne M Pursley, Dmitry Dukhovny
Work within the US health care system has sought to improve outcomes, decrease costs, and improve the patient experience. Combining those three elements leads to value-added care. Quality improvement within neonatology has focused primarily on the improvement of clinical outcomes without explicit consideration of cost. Future improvement efforts in neonatology should consider opportunities to decrease or eliminate waste, and improve outcomes. Consideration of how a change affects all stakeholders reveals potential cost-saving opportunities, and developing aims with value in mind facilitates understanding and goal-setting with senior administrative leaders...
September 2017: Clinics in Perinatology
https://www.readbyqxmd.com/read/28798220/vascular-access-type-and-clinical-outcomes-among-elderly-patients-on-hemodialysis
#17
Timmy Lee, Mae Thamer, Qian Zhang, Yi Zhang, Michael Allon
BACKGROUND AND OBJECTIVES: The optimal type of initial permanent access for hemodialysis among the elderly is controversial. Duration of central venous catheter dependence, patient comorbidities, and life expectancy are important considerations in whether to place an arteriovenous fistula or graft. We used an observational study design to compare clinical outcomes in elderly patients who initiated hemodialysis with a central venous catheter and subsequently had an arteriovenous fistula or graft placed...
August 10, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28756013/5-or-and-20-o-alkyl-2-3-dehydrosilybins-synthesis-and-biological-profiles-on-prostate-cancer-cell-models
#18
Bao Vue, Xiaojie Zhang, Timmy Lee, Nandini Nair, Sheng Zhang, Guanglin Chen, Qiang Zhang, Shilong Zheng, Guangdi Wang, Qiao-Hong Chen
To investigate the effects of alkylation at 5-OH and 20-OH of 2,3-dehydrosilybin on prostate cancer cell proliferation, the synthetic approaches to 5- or/and 20-O-alkyl-2,3-dehydrosilybins, through a multi-step sequence from commercially available silybin, have been successfully developed. The first three reactions in the syntheses were completed through a one-pot procedure by managing anaerobic and aerobic conditions. With these synthetic methods in hand, twenty-one 2,3-dehydrosilybins, including seven 20-O-alkyl, seven 5,20-O-dialkyl, and seven 5-O-alkyl-2,3-dehydrosilybins, have been achieved for the evaluation of their biological profiles...
September 1, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28729383/definitions-and-end-points-for-interventional-studies-for-arteriovenous-dialysis-access
#19
Gerald A Beathard, Charmaine E Lok, Marc H Glickman, Ahmed A Al-Jaishi, Donna Bednarski, David L Cull, Jeffery H Lawson, Timmy C Lee, Vandana D Niyyar, Donna Syracuse, Scott O Trerotola, Prabir Roy-Chaudhury, Surendra Shenoy, Margo Underwood, Haimanot Wasse, Karen Woo, Theodore H Yuo, Thomas S Huber
This paper is part of the Clinical Trial Endpoints for Dialysis Vascular Access Project of the American Society of Nephrology Kidney Health Initiative. The purpose of this project is to promote research in vascular access by clarifying trial end points which would be best suited to inform decisions in those situations in which supportive clinical data are required. The focus of a portion of the project is directed toward arteriovenous access. There is a potential for interventional studies to be directed toward any of the events that may be associated with an arteriovenous access' evolution throughout its life cycle, which has been divided into five distinct phases...
July 20, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28710090/the-clinical-and-economic-effect-of-vascular-access-selection-in-patients-initiating-hemodialysis-with-a-catheter
#20
Alian Al-Balas, Timmy Lee, Carlton J Young, Jeffrey A Kepes, Jill Barker-Finkel, Michael Allon
Patients in the United States frequently initiate hemodialysis with a central venous catheter (CVC) and subsequently undergo placement of a new arteriovenous fistula (AVF) or arteriovenous graft (AVG). Little is known about the clinical and economic effects of initial vascular access choice. We identified 479 patients starting hemodialysis with a CVC at a large medical center (during 2004-2012) who subsequently had an AVF (n=295) or AVG (n=105) placed or no arteriovenous access (CVC group, n=71). Compared with patients receiving an AVG, those receiving an AVF had more frequent surgical access procedures per year (1...
July 14, 2017: Journal of the American Society of Nephrology: JASN
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