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Muscle hypertrophy

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https://www.readbyqxmd.com/read/29662554/effect-of-%C3%AE-hydroxy-%C3%AE-methylbutyrate-on-mirna-expression-in-differentiating-equine-satellite-cells-exposed-to-hydrogen-peroxide
#1
Karolina A Chodkowska, Anna Ciecierska, Kinga Majchrzak, Piotr Ostaszewski, Tomasz Sadkowski
Background: Skeletal muscle injury activates satellite cells to initiate processes of proliferation, differentiation, and hypertrophy in order to regenerate muscle fibers. The number of microRNAs and their target genes are engaged in satellite cell activation. β-Hydroxy-β-methylbutyrate (HMB) is known to prevent exercise-induced muscle damage. The purpose of this study was to evaluate the effect of HMB on miRNA and relevant target gene expression in differentiating equine satellite cells exposed to H2 O2 ...
2018: Genes & Nutrition
https://www.readbyqxmd.com/read/29658408/the-compatibility-of-concurrent-high-intensity-interval-training-and-resistance-training-for-muscular-strength-and-hypertrophy-a-systematic-review-and-meta-analysis
#2
Angelo Sabag, Abdolrahman Najafi, Scott Michael, Tuguy Esgin, Mark Halaki, Daniel Hackett
The purpose of this systematic review and meta-analysis is to assess the effect of concurrent high intensity interval training (HIIT) and resistance training (RT) on strength and hypertrophy. Five electronic databases were searched using terms related to HIIT, RT, and concurrent training. Effect size (ES), calculated as standardised differences in the means, were used to examine the effect of concurrent HIIT and RT compared to RT alone on muscle strength and hypertrophy. Sub-analyses were performed to assess region-specific strength and hypertrophy, HIIT modality (cycling versus running), and inter-modal rest responses...
April 16, 2018: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29652692/potential-roles-of-vascular-endothelial-growth-factor-during-skeletal-muscle-hypertrophy
#3
Kimberly A Huey
Vascular endothelial growth factor (VEGF) deletion in adult mouse muscle fibers contributes to impaired contractile and muscular adaptations to a hypertrophic stimulus suggesting a critical role in adult muscle growth. This review will explore the hypothesis that VEGF is essential for adult muscle growth by impacting inflammatory processes, satellite-endothelial cell interactions, and contractile protein accumulation by functioning within known hypertrophic signaling pathways including insulin-like growth factor-1 (IGF-1-Akt) and Wnt-ß-catenin...
April 12, 2018: Exercise and Sport Sciences Reviews
https://www.readbyqxmd.com/read/29651792/the-plantaris-muscle-rare-relations-to-the-neurovascular-bundle-in-the-popliteal-fossa
#4
Ł Olewnik, M Podgórski, M Polguj, M Topol
The plantaris muscle is characterized by morphological variability, both for origin and insertion, and may sometimes be absent. Its strength allows the ligament to be used for reconstruction of other tendons and ligaments. This report presents the rare placements and course of the plantaris muscle in relation to the neurovascular bundle. In this case, the hypertrophy of this muscle might cause pressure on the tibial nerve and produce symptoms similar to sciatica.
April 13, 2018: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/29644392/effect-of-a-rest-pause-vs-traditional-squat-on-electromyography-and-lifting-volume-in-trained-women
#5
John A Korak, Max R Paquette, Dana K Fuller, Jennifer L Caputo, John M Coons
PURPOSE: Rest-pause (4 s unloaded rest between repetitions) single session training effects on lifting volume, and muscle activity via electromyography (EMG) are currently vague in the literature and can benefit strength and conditioning professionals for resistance training program design. This study compared differences in volume lifted and muscle activity between a rest-pause vs. traditional protocol. METHODS: Trained females (N = 13) completed both a rest-pause and traditional squat protocol consisting of four sets to movement failure at 80% pretest 1 repetition maximum load with 2-min rest between sets...
April 11, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29621305/biomarkers-associated-with-low-moderate-and-high-vastus-lateralis-muscle-hypertrophy-following-12-weeks-of-resistance-training
#6
Christopher B Mobley, Cody T Haun, Paul A Roberson, Petey W Mumford, Wesley C Kephart, Matthew A Romero, Shelby C Osburn, Christopher G Vann, Kaelin C Young, Darren T Beck, Jeffrey S Martin, Christopher M Lockwood, Michael D Roberts
We sought to identify biomarkers which delineated individual hypertrophic responses to resistance training. Untrained, college-aged males engaged in full-body resistance training (3 d/wk) for 12 weeks. Body composition via dual x-ray absorptiometry (DXA), vastus lateralis (VL) thickness via ultrasound, blood, VL muscle biopsies, and three-repetition maximum (3-RM) squat strength were obtained prior to (PRE) and following (POST) 12 weeks of training. K-means cluster analysis based on VL thickness changes identified LOW [n = 17; change (mean±SD) = +0...
2018: PloS One
https://www.readbyqxmd.com/read/29610615/surgical-management-of-facial-features-of-robinow-syndrome-a-case-report
#7
Aida M Mossaad, Moustapha A Abdelrahman, Mostafa A Ibrahim, Hatem H Al Ahmady
BACKGROUND: Robinow Syndrome is an extremely rare genetic disorder characterised by abnormalities in head, face and external genitalia. This disorder exists in dominant pattern with moderate symptoms and recessive pattern with more physical and skeletal abnormalities. It was first introduced by Menihard Robinow in 1969. It was related to chromosome 9q22 ROR2 gene related to bone and cartilage growth aspects. CASE PRESENTATION: A 17-year-old Egyptian male presented to National Research Centre Orodental genetics Clinic with typical features of short stature and facial dysmorphism weighted 50 Kg and measured 150 cm height complaining of facial dis figurement...
March 15, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29607314/glucagon-like-peptide-1-mediates-the-protective-effect-of-the-dipeptidyl-peptidase-iv-inhibitor-on-renal-fibrosis-via-reducing-the-phenotypic-conversion-of-renal-microvascular-cells-in-monocrotaline-treated-rats
#8
Jian Xu, Jingjing Wang, Yusheng Cheng, Xiang Li, Mengyu He, Jiali Zhu, Honghao Han, Guihong Wei, Hui Kong, Weiping Xie, Hong Wang, Xiangrong Zuo
Chronic kidney diseases are characterized by renal fibrosis with excessive matrix deposition, leading to a progressive loss of functional renal parenchyma and, eventually, renal failure. Renal microcirculation lesions, including the phenotypic conversion of vascular cells, contribute to renal fibrosis. Here, renal microcirculation lesions were established with monocrotaline (MCT, 60 mg/kg). Sitagliptin (40 mg/kg/d), a classical dipeptidyl peptidase-4 (DPP-4) inhibitor, attenuated the renal microcirculation lesions by inhibiting glomerular tuft hypertrophy, glomerular mesangial expansion, and microvascular thrombosis...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29604268/mild-aerobic-training-with-blood-flow-restriction-increases-the-hypertrophy-index-and-musk-in-both-slow-and-fast-muscles-of-old-rats-role-of-pgc-1%C3%AE
#9
Mohammad-Ali Bahreini Pour, Siyavash Joukar, Fariborz Hovanloo, Hamid Najafipour, Vida Naderi, Alireza Raji, Saeed Esmaeili-Mahani
AIMS: Existing evidence emphasize the role of mitochondrial dysfunction in sarcopenia which is revealed as loss of skeletal muscle mass and neuromuscular junction remodeling. We assessed the effect of low-intensity aerobic training along with blood flow restriction on muscle hypertrophy index, muscle-specific kinase (MuSK), a pivotal protein of the neuromuscular junction and Peroxisome proliferator-activated receptor gamma co-activator 1-alpha (PGC-1α) in aged male rats. MAIN METHODS: Animals groups were control (CTL), sham (Sh), leg blood flow restriction (BFR), exercise (Ex), sham + exercise (Sh + Ex), and BFR plus exercise (BFR + Ex) groups...
March 28, 2018: Life Sciences
https://www.readbyqxmd.com/read/29602755/pathoanatomic-findings-and-treatment-during-hypertrophic-obstructive-cardiomyopathy-surgery-the-role-of-mitral-valve
#10
Giuseppe M Raffa, Giuseppe Romano, Marco Turrisi, Marco Morsolini, Giovanni Gentile, Sergio Sciacca, Alessandro Armaro, Vincenzo Stringi, Gabriella Mattiucci, Serena Magro, Fabiola Cosentino, Francesco Clemenza, Michele Pilato
BACKGROUND: To assess the role of the mitral valve apparatus (leaflets, chordae and papillary muscles, PM) in left ventricle outflow tract (LVOT) obstruction, and results of the surgical treatment for hypertrophic obstructive cardiomyopathy (HOCM). METHODS: Twenty-eight consecutive patients (58±11years, 53% female) undergoing HOCM surgery from 2007 to 2016 at our institute were retrospectively reviewed. Endpoints included the involvement of the mitral valve in LVOT obstruction, mortality, and changes in clinical and echocardiographic characteristics after HOCM surgery...
February 14, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29594644/non-osteogenic-muscle-hypertrophy-in-children-with-mcardle-disease
#11
I Rodríguez-Gómez, A Santalla, J Díez-Bermejo, D Munguía-Izquierdo, L M Alegre, G Nogales-Gadea, J Arenas, M A Martín, A Lucía, I Ara
INTRODUCTION: McArdle disease is an inborn disorder of muscle glycogen metabolism that produces exercise intolerance, and has been recently associated with low values ​​of lean mass (LM) and bone mineral content (BMC) and density (BMD) in affected adults. Here we aimed to study whether this bone health problem begins in childhood. METHODS: Forty children and adolescents were evaluated: 10 McArdle disease and 30 control children (mean age of both groups, 13 ± 2y)...
March 28, 2018: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/29590139/the-effects-of-unilateral-and-bilateral-eccentric-overload-training-on-hypertrophy-muscle-power-and-cod-performance-and-its-determinants-in-team-sport-players
#12
Francisco Javier Núñez, Alfredo Santalla, Irene Carrasquila, Jose Antonio Asian, Jose Ignacio Reina, Luis Jesús Suarez-Arrones
The study aimed to compare the chronic eccentric-overload training effects of unilateral (lateral lunge) vs bilateral (half-squat) using an inertial device, on hypertrophy and physical performance. Twenty-seven young team sports male players performed a 4 sets of 7 repetitions of inertial eccentric overload training, biweekly for 6 weeks, distributed in unilateral lunge group (UG: age: 22.8 ± 2.9 years; body mass: 75.3 ± 8.8 kg; height: 177.3 ± 3.7 cm) and bilateral squat group (BG: age: 22.6 ± 2.7 years; body mass: 79...
2018: PloS One
https://www.readbyqxmd.com/read/29584518/planned-load-reduction-versus-fixed-load-a-strategy-to-reduce-the-perception-of-effort-with-similar-improvements-in-hypertrophy-and-strength
#13
Bruce M Lima, Rafael S Amancio, Diacre S Gonçalves, Alexander J Koch, Victor M Curty, Marco Machado
PURPOSE: The purpose of this study was to compare muscle thickness and 10RM between no load reduction and load reductions during 16 weeks of resistance training (RT). METHODS: Twenty-one moderately trained men (age: 23.2±4.2 years, body mass: 75.1±7.6 Kg, height: 175±4 cm) were randomized into one of three exercise groups: Control (CON, n=7), all sets with 10RM load; 5% load reduction (RED5, n=7), and 10% load reduction (RED10, n=7) for set 2 and set 3. The RT program consisted of completed three sets each of Biceps and Scott Curls, performed to volitional fatigue 3d·wk-1 ...
March 27, 2018: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/29578650/quantification-of-alignment-of-vascular-smooth-muscle-cells
#14
Marcel P Dorta, Isis V de Brito, Alexandre C Pereira, Adriano M Alencar
Vascular smooth muscle cells (VSMCs) are essential components that keep the tonus of the arterial network, which is the channel used to conduct the blood from the heart to the peripheral areas of the body. It is known that mechanical and architectural changes in VSMCs may lead to functional modifications in the cardiovascular system; therefore, the quantitative characterization of these changes can help to elucidate questions that remain unclear in pathological situations, such as hypertension, vasospasm, vascular hypertrophy, and atherosclerosis...
March 26, 2018: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
https://www.readbyqxmd.com/read/29577974/repetitions-to-failure-versus-not-to-failure-during-concurrent-training-in-healthy-elderly-men-a-randomized-clinical-trial
#15
Larissa Xavier da Silva Neves, Juliana Lopes Teodoro, Erik Menger, Pedro Lopez, Rafael Grazioli, Juliano Farinha, Kelly Moraes, Martim Bottaro, Ronei Silveira Pinto, Mikel Izquierdo, Eduardo Lusa Cadore
This randomized clinical trial compared the neuromuscular adaptations induced by concurrent training (CT) performed with repetitions to concentric failure and not to failure in elderly men. Fifty-two individuals (66.2 ± 5.2 years) completed the pre- and post-measurements and were divided into three groups: repetitions to failure (RFG, n = 17); repetitions not to failure (NFG, n = 20); and repetitions not to failure with total volume equalized to RFG (ENFG, n = 15). Participants were assessed in isometric knee extension peak torque (PTiso ), maximal strength (1RM) in the leg press (LP) and knee extension (KE) exercises, quadriceps femoris muscle thickness (QF MT), specific tension, rate of torque development (RTD) at 50, 100 and 250 ms, countermovement jump (CMJ) and squat jump (SJ) performance, as well as maximal neuromuscular activity (EMGmax ) of the vastus lateralis (VL) and rectus femoris (RF) muscles...
March 22, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29577809/spectrum-of-neuromuscular-disorders-with-hyperckemia-from-a-tertiary-care-pediatric-neuromuscular-center
#16
Fouad Al-Ghamdi, Basil T Darras, Partha S Ghosh
Elevated creatine kinase is a useful screening test in the diagnostic workup of patients with neuromuscular disorders. We did a retrospective study of children with hyperCKemia (>175 IU/L) who were followed in the neuromuscular program of a tertiary care pediatric center from 2005 to 2016. Patients with hyperCKemia were divided into 2 groups: myopathic and nonmyopathic. Within the myopathic group, there were 3 arbitrary subgroups based on creatine kinase values: A (creatine kinase >10 times normal), B (creatine kinase 5-10 times normal), and C (creatine kinase 1-5 times normal)...
January 1, 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29575714/blood-flow-restricted-exercise-providing-more-bang-for-buck-in-trained-athletes
#17
EDITORIAL
Richard A Ferguson
Blood flow restriction (BFR) has been utilised in physiology for centuries; from William Harvey's (1578-1657) initial use of a tourniquet to describe in detail the systemic circulation of blood, to the use in the last 40 years in the investigation of cardiovascular reflex responses, angiogenesis, skeletal muscle metabolism and fatigue. Recent investigation has largely focussed on the adaptive potential of BFR exercise training, with particular reference to skeletal muscle strength and hypertrophy and its use in the rehabilitation process...
March 25, 2018: Acta Physiologica
https://www.readbyqxmd.com/read/29575057/adiponectin-synthesis-and-secretion-by-subcutaneous-adipose-tissue-is-impaired-during-obesity-by-endoplasmic-reticulum-stress
#18
Ivan Torre-Villalvazo, Ana E Bunt, Gabriela Alemán, Claudia C Marquez-Mota, Andrea Diaz-Villaseñor, Lilia G Noriega, Isabela Estrada, Elizabeth Figueroa-Juárez, Claudia Tovar-Palacio, Leonardo A Rodriguez-López, Patricia López-Romero, Nimbe Torres, Armando R Tovar
Subcutaneous (SAT) and visceral (VAT) adipose tissues stores excess energy as triglycerides and synthesize adiponectin to prevent ectopic lipid accumulation and lipotoxicity. During obesity, an impairment in the capacity of SAT to store triglycerides and synthesize adiponectin is associated with increased free fatty acids (FFA) release, leading to VAT hypertrophy and hepatic and skeletal muscle lipotoxicity. Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) may be involved in SAT dysfunction during obesity...
March 25, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29572181/urinary-bladder-organ-hypertrophy-is-partially-regulated-by-akt1-mediated-protein-synthesis-pathway
#19
Li-Ya Qiao, Chunmei Xia, Shanwei Shen, Seong Ho Lee, Paul H Ratz, Matthew O Fraser, Amy Miner, John E Speich, Jeffrey J Lysiak, William D Steers
AIMS: The present study aims to investigate the role of Akt in the regulation of urinary bladder organ hypertrophy caused by partial bladder outlet obstruction (pBOO). MAIN METHODS: Male rats were surgically induced for pBOO. Real-time PCR and western blot were used to examine the levels of mRNA and protein. A phosphoinositide 3-kinase (PI3K) inhibitor LY294002 was used to inhibit the activity of endogenous Akt. KEY FINDINGS: The urinary bladder developed hypertrophy at 2 weeks of pBOO...
March 20, 2018: Life Sciences
https://www.readbyqxmd.com/read/29570537/myocellular-responses-to-concurrent-flywheel-training-during-70-days-of-bed-rest
#20
Kevin A Murach, Kiril Minchev, Greg J Grosicki, Kaleen Lavin, Ryan K Perkins, Jeffrey W Ryder, Jessica Scott, Lori Ploutz-Snyder, Todd A Trappe, Scott Trappe
PURPOSE: This investigation evaluated myocellular responses to an integrated resistance and aerobic training program (SPRINT) during 70 days of bed rest. METHODS: Training was six days per week on a small-footprint gravity-independent flywheel resistance and aerobic device (FLY); three days of maximal flywheel supine quadriceps and calf exercises with continuous rowing separated by 4-6 hours, and three days of interval rowing. Vastus lateralis (VL) and soleus (SOL) muscle biopsies were obtained from eight healthy males (age=28±4 y, BMI=25±3 kg•m, VO2max=42±6 ml•kg•min) before and after 6° head-intrdown tilt bed rest...
March 22, 2018: Medicine and Science in Sports and Exercise
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