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https://www.readbyqxmd.com/read/29044172/circulating-mir-19b-and-mir-181b-are-potential-biomarkers-for-diabetic-cardiomyopathy
#1
Camila Uribe Copier, Luis León, Mauricio Fernández, David Contador, Sebastián D Calligaris
Diabetic cardiomyopathy is characterized by metabolic changes in the myocardium that promote a slow and silent dysfunction of muscle fibers, leading to myocardium remodelling and heart failure, independently of the presence of coronary artery diseases or hypertension. At present, no imaging methods allow an early diagnosis of this disease. Circulating miRNAs in plasma have been proposed as biomarkers in the prognosis of several cardiac diseases. This study aimed to determine whether circulating miRNAs could be potential biomarkers of diabetic cardiomyopathy...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29043659/magnitude-of-muscle-strength-and-mass-adaptations-between-high-load-resistance-training-versus-low-load-resistance-training-associated-with-blood-flow-restriction-a-systematic-review-and-meta-analysis
#2
REVIEW
Manoel E Lixandrão, Carlos Ugrinowitsch, Ricardo Berton, Felipe C Vechin, Miguel S Conceição, Felipe Damas, Cleiton A Libardi, Hamilton Roschel
BACKGROUND: Low-load resistance training (< 50% of one-repetition maximum [1RM]) associated with blood-flow restriction (BFR-RT) has been thought to promote increases in muscle strength and mass. However, it remains unclear if the magnitude of these adaptations is similar to conventional high-load resistance training (> 65% 1RM; HL-RT). OBJECTIVE: To compare the effects of HL- versus BFR-RT on muscle adaptations using a systematic review and meta-analysis procedure...
October 17, 2017: Sports Medicine
https://www.readbyqxmd.com/read/29040438/geometric-predictors-of-left-ventricular-outflow-tract-obstruction-in-patients-with-hypertrophic-cardiomyopathy-a-3d-computed-tomography-analysis
#3
Yunsun Song, Dong Hyun Yang, Bríain Ó Hartaigh, Se Jin Cho, Joon-Won Kang, Young-Hak Kim, Joon Bum Kim, Dae-Hee Kim, Jong-Min Song, Duk-Hyun Kang, Jae-Kwan Song, Tae-Hwan Lim
Aims: To establish geometric predictors of left ventricular outflow tract obstruction (LVOTO) in hypertrophic cardiomyopathy (HCM) patients by use of cardiac computed tomography (CT). Methods and results: A total of 141 consecutive patients with HCM who underwent cardiac CT comprised the analytic sample. The degree, pattern, and extent of left ventricular (LV) hypertrophy were evaluated using 3D CT. Abnormality of papillary muscle (PM), mitral valve, and aorto-mitral angle were evaluated quantitatively...
October 11, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29040400/treatment-of-gastrocnemius-muscle-hypertrophy-with-botulinum-toxin-injection-followed-by-magnetic-resonance-imaging-assessment-and-3-dimensional-evaluation
#4
Melia Bogari, Andy Tan, Yu Xin, Gang Chai, Li Lin, Peiru Min, Yan Zhang, Yixin Zhang
Background: Hypertrophy of the gastrocnemius muscle is considered to be a hindrance to lower leg beauty in the Asian aesthetic market. A noninvasive technique that has been gaining recognition involves botulinum toxin A injection; however, there are no proper guidelines or standardized protocols for the administration of botulinum toxin to correct gastrocnemius hypertrophy. Objectives: This study sought to determine the most effective botulinum toxin injection method for correcting the contour of the lower leg calf, as well as to determine the dose that can produce the maximum effect in meeting the demands of the physician and patient...
August 10, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29040223/effect-of-losartan-on-the-acute-response-of-human-elderly-skeletal-muscle-to-exercise
#5
Mette Flindt Heisterberg, Jesper L Andersen, Peter Schjerling, Jacob Bülow, Jeppe Bo Lauersen, Heidi L Roeber, Michael Kjaer, Abigail L Mackey
PURPOSE: To investigate the effect of blocking the angiotensin II type I receptor (AT1R) upon the response to acute heavy resistance exercise in elderly human skeletal muscle. The hypothesis was that AT1R blocking would result in a superior myogenic response accompanied by downregulation of TGF-β and upregulation of IGF-1 signalling. METHODS: 28 healthy elderly men (+64 years) were randomized into two groups, consuming either AT1R blocker (Losartan, 100mg/day) or Placebo for 18 days prior to exercise...
October 16, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29037326/%C3%AE-hydroxy-%C3%AE-methylbutyrate-free-acid-supplementation-may-improve-recovery-and-muscle-adaptations-after-resistance-training-a-systematic-review
#6
REVIEW
Vagner R Silva, Felipe L Belozo, Thayana O Micheletti, Marcelo Conrado, Jeffrey R Stout, Gustavo D Pimentel, Adam M Gonzalez
β-Hydroxy-β-methylbutyrate free acid (HMB-FA) has been suggested to accelerate the regenerative capacity of skeletal muscle after high-intensity exercise and attenuate markers of skeletal muscle damage. Herein a systematic review on the use of HMB-FA supplementation as an ergogenic aid to improve measures of muscle recovery, performance, and hypertrophy after resistance training was conducted. This review was performed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. We included randomized, double-blinded, placebo-controlled trials investigating the effects of HMB-FA supplementation in conjunction with resistance exercise in humans...
September 2017: Nutrition Research
https://www.readbyqxmd.com/read/29033571/bronchial-thermoplasty-and-the-role-of-airway-smooth-muscle-are-we-on-the-right-direction
#7
REVIEW
Francesco Menzella, Mirco Lusuardi, Carla Galeone, Nicola Facciolongo
Asthma is characterized by inflammation of the airways that includes eosinophils, basal membrane thickening, epithelial sloughing, vascular changes, smooth muscle hypertrophy and hyperplasia, and mucous gland hyperplasia. Recently, there have been studies on the role of hypersensitivity and inflammation in asthma, but the role of bronchial smooth muscle remains unclear. Bronchial thermoplasty is an endoscopic procedure that is approved by the US Food and Drug Administration (FDA) for the treatment of severe refractory asthma, based on the local delivery of radio frequency at 65°C to the airways, with the aim of controlling bronchospasm through a reduction of airway smooth muscle (ASM)...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29032314/remodeling-of-arterial-wall-response-to-changes-in-both-blood-flow-and-blood-pressure
#8
Kozaburo Hayashi, Akihisa Makino, Daichi Kakoi
Many studies have been performed on arterial responses to chronic changes in blood flow (BF) and blood pressure (BP). However, little is known about the effects of simultaneous changes in BF and BP. The present study was carried out to know biomechanical responses of arterial wall to the combination of increased BP, i.e. hypertension (HT), with lower or higher BF than normal, and the results were compared with those observed under normal BP, i.e. normotension (NT), combined with these BF conditions. Eight weeks old rats were subjected to BF and/or BP changes for 8 weeks until 16 weeks of age...
October 7, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29030277/isolated-unilateral-temporalis-muscle-hypertrophy-first-case-in-an-8-year-old-boy-and-review
#9
Narcisse Zwetyenga, Anna Hallier, Marine Girodon, Julie Levasseur, Ludwig Loison-Robert, Vivien Moris
INTRODUCTION: Isolated Unilateral Temporalis Muscle Hypertrophy (IUTMH) was first described in 1990, and few cases have been published since then. This disease occurs mainly in adults. There is no clear etiology of IUTMH, but bruxism is one of the risk factors. Only two cases have been described before the age of 20 years. To our knowledge, no cases have been described in persons younger than 15 years old. We report the first case of IUTMH in an 8-year-old and review the literature. MATERIAL AND METHODS: This section is separated into 3 parts: 1- search for and description of clinical cases of IUTMH in our department; 2- literature search to find similar cases; 3- data analysis of all cases found...
October 10, 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29025412/dynamic-transcriptome-and-dna-methylome-analyses-on-longissimus-dorsi-to-identify-genes-underlying-intramuscular-fat-content-in-pigs
#10
Yuding Wang, Cai Ma, Yi Sun, Yi Li, Li Kang, Yunliang Jiang
BACKGROUND: The intramuscular fat content (IMF) refers to the amount of fat within muscles, including the sum of phospholipids mainly found in cell membranes, triglycerides and cholesterol, and is determined both by hyperplasia and hypertrophy of adipocyte during the development of pigs. The IMF content is an important economic trait that is genetically controlled by multiple genes. The Laiwu pig is an indigenous fatty pig breed distributed in North China, characterized by excessively higher level of IMF content (9%~12%), therefore, is suitable for the identification of genes controlling IMF variations...
October 12, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29024332/effect-of-resistance-training-set-volume-on-upper-body-muscle-hypertrophy-are-more-sets-really-better-than-less
#11
REVIEW
Cauê V La Scala Teixeira, Yuri Motoyama, Paulo Henrique Silva Marques de Azevedo, Alexandre Lopes Evangelista, James Steele, Danilo Sales Bocalini
BACKGROUND: Resistance training (RT) for upper body muscle hypertrophy (UBMH) typically entails high volumes of sets per muscle group per training session. The majority of RT regimens does not discriminate between upper and lower body muscle groups, while these groups may respond differently to RT set volumes in terms of maximum skeletal muscle mass gain. Recent studies have examined the effect of different set volumes on the extent of UBMH to formulate optimal RT regimens and to make RT programmes more time-efficient...
October 11, 2017: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/29022275/volume-for-muscle-hypertrophy-and-health-outcomes-the-most-effective-variable-in-resistance-training
#12
Vandré Casagrande Figueiredo, Belmiro Freitas de Salles, Gabriel S Trajano
Resistance training is the most effective method to increase muscle mass. It has also been shown to promote many health benefits. Although it is deemed safe and of clinical relevance for treating and preventing a vast number of diseases, a time-efficient and minimal dose of exercise has been the focus of a great number of research studies. Similarly, an inverted U-shaped relationship between training dose/volume and physiological response has been hypothesized to exist. However, the majority of available evidence supports a clear dose-response relationship between resistance training volume and physiological responses, such as muscle hypertrophy and health outcomes...
October 11, 2017: Sports Medicine
https://www.readbyqxmd.com/read/29022261/the-non-cardiomyocyte-cells-of-the-heart-their-possible-roles-in-exercise-induced-cardiac-regeneration-and-remodeling
#13
Ivan Varga, Jan Kyselovič, Paulina Galfiova, Lubos Danisovic
The non-cardiomyocyte cellular microenvironment of the heart includes diverse types of cells of mesenchymal origin. During development, the majority of these cells derive from the epicardium, while a subset derives from the endothelium/endocardium and neural crest derived mesenchyme. This subset includes cardiac fibroblasts and telocytes, the latter of which are a controversial type of "connecting cell" that support resident cardiac progenitors in the postnatal heart. Smooth muscle cells, pericytes, and endothelial cells are also present, in addition to adipocytes, which accumulate as epicardial adipose connective tissue...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29021917/a-feasibility-pilot-using-telehealth-videoconference-monitoring-of-home-based-nmes-resistance-training-in-persons-with-spinal-cord-injury
#14
Ashraf S Gorgey, Robert M Lester, Rodney C Wade, Refka E Khalil, Rehan K Khan, Melodie L Anderson, Teodoro Castillo
INTRODUCTION: The objective of the study was to investigate the feasibility and initial efficacy of telehealth communication in conjunction with surface neuromuscular electrical stimulation (NMES) resistance training (RT) to induce muscle hypertrophy. MATERIALS AND METHODS: This was a home-based setting of within-subject control design of trained vs controlled limbs. Five men with chronic (>1 year postinjury) motor-complete spinal cord injury (SCI) participated in a twice-weekly telehealth videoconference program using home-based NMES-RT for 8 weeks...
2017: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/29018363/moderate-load-muscular-endurance-strength-training-did-not-improve-peak-power-or-functional-capacity-in-older-men-and-women
#15
Simon Walker, Guy G Haff, Keijo Häkkinen, Robert U Newton
The present study determined the effects of muscular endurance strength training on maximum strength and power, functional capacity, muscle activation and hypertrophy in older men and women. Eighty-one men and women acted as an intervention group while 22 acted as non-training controls (age range 64-75 y). Intervention training included super-sets (i.e., paired exercises, immediately performing the second exercises following completion of the first) with short rest intervals (30-60 s between sets) at an intensity of 50-60% one-repetition maximum (1-RM) for 15-20 repetitions...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29017166/the-role-of-the-mineralocorticoid-receptor-in-inflammation-focus-on-kidney-and-vasculature
#16
Zachary Belden, Jeffrey A Deiuliis, Mirela Dobre, Sanjay Rajagopalan
BACKGROUND: The remarkable success of clinical trials in mineralocorticoid receptor (MR) inhibition in heart failure has driven research on the physiological and pathological role(s) of nonepithelial MR expression. MR is widely expressed in the cardiovascular system and is a major determinant of endothelial function, smooth muscle tone, vascular remodeling, fibrosis, and blood pressure. An important new dimension is the appreciation of the role MR plays in immune cells and target organ damage in the heart, kidney and vasculature, and in the development of insulin resistance...
October 10, 2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/28979816/post-translationally-modified-muscle-specific-ubiquitin-ligases-as-circulating-biomarkers-in-experimental-cancer-cachexia
#17
Roberto Mota, Jessica E Rodríguez, Andrea Bonetto, Thomas M O'Connell, Scott A Asher, Traci L Parry, Pamela Lockyer, Christopher R McCudden, Marion E Couch, Monte S Willis
Cancer cachexia is a severe wasting syndrome characterized by the progressive loss of lean body mass and systemic inflammation. Up to 80% of cancer patients experience cachexia, with 20-30% of cancer-related deaths directly linked to cachexia. Despite efforts to identify early cachexia and cancer relapse, clinically useful markers are lacking. Recently, we identified the role of muscle-specific ubiquitin ligases Atrogin-1 (MAFbx, FBXO32) and Muscle Ring Finger-1 in the pathogenesis of cardiac atrophy and hypertrophy...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28972174/sirtuin-5-is-required-for-mouse-survival-in-response-to-cardiac-pressure-overload
#18
Kathleen A Hershberger, Dennis M Abraham, Angelical S Martin, Lan Mao, Juan Liu, Hongbo Gu, Jason W Locasale, Matthew D Hirschey
In mitochondria, the sirtuin SIRT5 is an NAD(+)-dependent protein deacylase that controls several metabolic pathways. While a wide range of SIRT5 targets has been identified, the overall function of SIRT5 in organismal metabolic homeostasis remains unclear. Given that SIRT5 expression is highest in the heart and that sirtuins are commonly stress-response proteins, we used an established model of pressure overload-induced heart muscle hypertrophy caused by transverse aortic constriction (TAC) to determine SIRT5's role in cardiac stress responses...
October 2, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28969103/histogenesis-of-muscularis-mucosa-and-muscularis-externa-of-stomach-a-human-foetal-study
#19
Babita Pangtey, Jagat Mohini Kaul, Sabita Mishra
INTRODUCTION: The histological and developmental knowledge of musculature of stomach wall is vital for the assessment and management of various associated congenital abnormalities like hypertrophy of pyloric musculature and pathologies of nerve terminals and ganglia. AIM: To study the development of muscularis mucosa and muscularis externa in human foetal stomach. MATERIALS AND METHODS: The study was conducted on 22 aborted human foetuses of varying gestational ages ranging from 10-26 weeks...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28967304/systemic-smad7-gene-therapy-increases-striated-muscle-mass-and-enhances-exercise-capacity-in-a-dose-dependent-manner
#20
Joseph Maricelli, Yemeserach Bishaw, Bo Wang, Min Du, Buel Dantese Rodgers
Striated muscle wasting occurs with a variety of disease indications, contributing to mortality and compromising life quality. Recent studies indicate that the recombinant adeno-associated viral (serotype 6) Smad7 gene therapeutic, AVGN7, enhances skeletal and cardiac muscle mass and prevents cancer-induced wasting of both tissues. This is accomplished by attenuating ActRIIb intracellular signaling and as a result, the physiological actions of myostatin and other ActRIIb ligands. AVGN7 also enhances isolated skeletal muscle twitch force, but is unknown to similarly improve systemic muscle function, especially exercise capacity...
October 1, 2017: Human Gene Therapy
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