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Gastric ulcer

Farajzadah Sheikh Ahmad, Mohammad Jaafar Yadyad, Hamed Goodarzi, Seyed Jalal Hashemi, Sajad Aslani, Mohammad-Ali Assarzadegan, Reza Ranjbar
BACKGROUND: Allelic variation of the virulence genes, vacA and cagA, as the most important virulence associated genes play an important role in the pathogenesis of severe gastrointestinal disease. OBJECTIVE: The aim of the present study was to identify the diversity of the virulence genes in patients with Gastric Cancer (GC), who were referred to the gastro-endoscopy unit of Imam Khomeini Hospital, Ahvaz Jundishapur University of medical science, Ahvaz, Iran. METHODS: Gastric biopsy specimens from 301 patients suspected to gastrointestinal disorders, were analyzed for H...
June 13, 2018: Microbial Pathogenesis
Prabhakar Lal Srivastava, Anurag Shukla, Raviraj M Kalunke
Asparagus racemosus (Shatavari), belongs to the family Asparagaceae and is known as a "curer of hundred diseases" since ancient time. This plant has been exploited as a food supplement to enhance immune system and regarded as a highly valued medicinal plant in Ayurvedic medicine system for the treatment of various ailments such as gastric ulcers, dyspepsia, cardiovascular diseases, neurodegenerative diseases, cancer, as a galactogogue and against several other diseases. In depth metabolic fingerprinting of various parts of the plant led to the identification of 13 monoterpenoids exclusively present in roots...
June 14, 2018: Scientific Reports
Maham Hayat, Sultan Mahmood, John T Maple
A 62-year-old male with long-standing esophageal reflux underwent endoscopy at an outside institution that reported multiple polypoid lesions in upper esophagus and a small focal area of nodular mucosa at the gastroesophageal junction(GEJ). Biopsies of the proximal esophageal polyps demonstrated hyperplastic mucosa with ulceration, reactive epithelial changes, and focal intestinal metaplasia. Biopsies from the nodular GEJ mucosa were described as Barrett's esophagus with low grade dysplasia. An upper endoscopy performed at our medical center found multiple semi-pedunculated esophageal polyps between 18-24 cm from the incisors (Figure A)...
June 11, 2018: Clinical Gastroenterology and Hepatology
Miho Yamamoto, Soji Ozawa, Kazuo Koyanagi, Junya Oguma, Akihito Kazuno, Yamato Ninomiya, Kentaro Yatabe, Kazuhito Hatanaka
BACKGROUND: Mixed adenoneuroendocrine carcinoma (MANEC) is a tumor of the gastrointestinal tract that contains both exocrine and endocrine components, with each component exceeding 30% of the total tumor area. Because MANECs are exceedingly rare, no therapeutic strategies have been established yet. CASE PRESENTATION: An 81-year-old man was referred to our hospital with a 5-month history of dysphagia. Esophagogastroduodenoscopy revealed an ulcerated mass in the lower thoracic esophagus, extending up to the esophagogastric junction (33 to 40 cm from the incisors)...
June 14, 2018: Surgical Case Reports
Gota Sudo, Tokuma Tanuma, Hiroshi Nakase
No abstract text is available yet for this article.
June 14, 2018: American Journal of Gastroenterology
Oscar Guzmán-Gómez, Rosa Virginia García-Rodríguez, Lucía Quevedo-Corona, Ricardo Pérez-Pastén-Borja, Nora Lilia Rivero-Ramírez, Emmanuel Ríos-Castro, Salud Pérez-Gutiérrez, Julia Pérez-Ramos, Germán Alberto Chamorro-Cevallos
Phycobiliproteins of Arthrospira ( Spirulina ) maxima have attracted attention because of their potential therapeutic antioxidant properties. The aim of this study was to assess the possible antiulcerogenic activity of these phycobiliproteins (ExPhy) against ethanol-induced gastric ulcers in rats. To explore the possible mechanisms of action, we examined antioxidant defense enzymes (e.g., catalase, superoxide dismutase, and glutathione peroxidase), as well as the level of lipid peroxidation (MDA) and the histopathological changes in the gastric mucosa...
June 13, 2018: Nutrients
Jean-Philippe Le Mouel, Julie Morvan, Mathurin Fumery, Sami Hakim, Richard Delcenserie, Denis Chatelain, Eric Nguyen-Khac
No abstract text is available yet for this article.
June 12, 2018: Endoscopy
Muhammad Alamzeb, Muhammad Omer, Mamoon Ur-Rashid, Muslim Raza, Saqib Ali, Behramand Khan, Asad Ullah
Urease enzyme is responsible for gastric cancer, peptic ulcer, hepatic coma, and urinary stones in millions of people across the world. So, there is a strong need to develop new and safe antiurease drugs, particularly from natural sources. In search for new and effective drugs from natural sources bioassay-guided fractionation and isolation of Berberis glaucocarpa Stapf roots bark resulted in the isolation and characterization, on the basis of 1D and 2D NMR data, of two bisbenzylisoquinoline alkaloids, oxyacanthine ( 1 ) and tetrandrine ( 2 ), followed by urease inhibition studies...
2018: Journal of Analytical Methods in Chemistry
Yu-Chi Juang, Xavier Fradera, Yongxin Han, Anthony William Partridge
Histidine decarboxylase (HDC) is the primary enzyme that catalyzes the conversion of histidine to histamine. HDC contributes to many physiological responses as histamine plays important roles in allergic reaction, neurological response, gastric acid secretion, and cell proliferation and differentiation. Small-molecule modulation of HDC represents a potential therapeutic strategy for a range of histamine-associated diseases, including inflammatory disease, neurological disorders, gastric ulcers, and select cancers...
June 1, 2018: SLAS Discovery
Olena M Komar, Nataliya M Kizlova, Oleksandra D Trylevych, Vasyl V Kravchenko
OBJECTIVE: Introduction: High morbidity rate, frequent relapses, and significant economic losses give reasons for highlighting the peptic ulcer disease as the most topical medical-statistical problem. The aim of the study is to assess the influence of the main risk factors on the course of gastric and duodenal peptic ulcer. PATIENTS AND METHODS: Materials and methods: We formed up the risk groups consisted of patients with 12 modified (4) and regular (8) factors, each characterized with its own signs and gradations...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
Mashooq Ahmad Bhat, Mohamed A Al-Omar, Mohammad Raish, Mushtaq Ahmad Ansari, Hatem A Abuelizz, Ahmed H Bakheit, Ahmed M Naglah
A new series of 2-(5-methoxy-2-methyl-1 H -indol-3-yl)- N ′-[( E )-(substituted phenyl) methylidene] acetohydrazide derivatives ( S1 ⁻ S18 ) were synthesized and evaluated for their anti-inflammatory activity, analgesic activity, ulcerogenic activity, lipid peroxidation, ulcer index and cyclooxygenase expression activities. All the synthesized compounds were in good agreement with spectral and elemental analysis. Three synthesized compounds ( S3 , S7 and S14 ) have shown significant anti-inflammatory activity as compared to the reference drug indomethacin...
May 24, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Robert Howard, Elizabeth Cort, Rosie Bradley, Emma Harper, Linda Kelly, Peter Bentham, Craig Ritchie, Suzanne Reeves, Waleed Fawzi, Gill Livingston, Andrew Sommerlad, Sabu Oomman, Ejaz Nazir, Ramin Nilforooshan, Robert Barber, Chris Fox, Ajay Verma Macharouthu, Pranathi Ramachandra, Vivek Pattan, John Sykes, Val Curran, Cornelius Katona, Tom Dening, Martin Knapp, Richard Gray
BACKGROUND: Very late (aged ≥60 years) onset schizophrenia-like psychosis occurs frequently but no placebo-controlled, randomised trials have assessed the efficacy and risks of antipsychotic treatment. We investigated whether low-dose amisulpride (100 mg daily) is superior to placebo in reducing psychosis symptoms over 12 weeks and whether any benefit is maintained by continuing treatment after 12 weeks. METHODS: The ATLAS double-blind controlled trial enrolled participants from 25 old age psychiatry services in the UK...
June 4, 2018: Lancet Psychiatry
Tzu-Chieh Lin, Chung-Lin Tsai, Yao-Tien Chang, Sung-Yuan Hu
BACKGROUND: Primary aortoduodenal fistula (ADF) is a rare cause of gastrointestinal (GI) bleeding and is difficult to diagnose as the clinical presentation is subtle. Clinicians should keep a high level of suspicion for an unknown etiology of GI bleeding, especially in older patients with or without abdominal aortic aneurysm (AAA). Computed tomographic angiography (CTA) can be used to detect primary ADF. Open surgery or endovascular aortic repair (EVAR) for ADF with bleeding will improve the survival rate...
June 7, 2018: BMC Cardiovascular Disorders
Predrag Sikiric, Rudolf Rucman, Branko Turkovic, Marko Sever, Robert Klicek, Bozo Radic, Domagoj Drmic, Mirjana Stupnisek, Marija Misic, Lovorka Batelja Vuletic, Katarina Horvat Pavlov, Ivan Barisic, Antonio Kokot, Marina Peklic, Sanja Strbe, Alenka Boban Blagaic, Ante Tvrdeic, Dinko Stancic Rokotov, Hrvoje Vrcic, Mario Staresinic, Sven Seiwerth
Years ago, we revealed a novel cytoprotective mediator, stable gastric pentadecapeptide BPC 157, particular anti-ulcer peptide that heals different organs lesions when given as a therapy, native in human gastric juice while maintaining GI- tract mucosal integrity, already tested in trials (ulcerative colitis and now multiple sclerosis). The stomach cytoprotection is the most fundamental concept, stomach cell protection and endothelium protection are largely elaborated, but so far cell, protection and endothelium protection outside of the stomach were not implemented in the therapy...
June 7, 2018: Current Pharmaceutical Design
Houcine Maghrebi, Makni Amine, Mohamed Jouini, Montassar Kacem, Zoubeir Ben Safta
A 70-year-old patient with a 20-year history of  gastric ulcer intervention presented for an abdominal mass appeared for 3 years . The clinical examination found a herniation on the median abdominal scar which is containing an irregular mobile renient mass. Computed abdominal tomography had objectified two voluminous liquid multilocular formations completely prolapsed in the hernia sac.
December 2017: La Tunisie Médicale
Amit Kishore Singh, Sandeep Kumar Singh, Prem Pratap Singh, Akhileshwar Kumar Srivastava, Kapil D Pandey, Ajay Kumar, Himanshu Yadav
Ulcer is one of the most common diseases affecting throughout the world population. The allopathic treatment of ulcer adversely affects the health by causing harmful side effects. Currently, many herbal plants and secondary metabolites have been used for the ulcer treatment. In the present review, many herbal plants and their parts (root, rhizome, bark, leaves and fruits) have been listed in the table are currently being used for ulcer treatment. These metabolites are responsible for ulcer-neutralization or anti-inflammatory properties...
June 2018: Biotechnology Reports
Ali Ibrahim Ali Al-Ezzy
OBJECTIVE: To determine the immunopathological correlation between Cag A+ H. pylori -specific IgG; pepsinogen I&II (PI&PII); gastrin-17 (G-17); status of gastric and duodenal mucosa and inflammatory activities on different gastroduodenal disorders. METHODOLOGY: Eighty gastroduodenal biopsies were taken from patients with gastroduodenal disorders for histopathological evaluation and H. pylori diagnosis. Serum samples were used for evaluation of gastric hormones and detection of H...
May 20, 2018: Open Access Macedonian Journal of Medical Sciences
C De Witte, R Ducatelle, F Haesebrouck
Ulceration of the non-glandular part of the stomach is a common disease entity of pigs worldwide, with prevalences of up to 93%. It may result in decreased daily weight gain, decreased feed intake and sudden death, thus leading to significant economic losses, as well as animal welfare issues. The aetiology is multifactorial. Diet particle size, management and infectious agents have been hypothesised to be involved. The exact mechanism behind porcine gastric ulceration is, however, not completely clear. The aim of this article is to provide an overview of the role of infectious agents in the development of porcine gastric ulceration...
June 2018: Veterinary Journal
Kaïs Rtibi, Dhekra Grami, Dalanda Wannes, Slimen Selmi, Mohamed Amri, Hichem Sebai, Lamjed Marzouki
ETHNOPHARMACOLOGICAL RELEVANCE: Ficus carica fruit, a source of bioactive functional ingredients, have been traditionally long time used for its medicinal benefits as they improve the digestive system, treating constipation and used as a natural laxative. AIM OF THE STUDY: The recent study was investigated the ameliorative effect of Ficus carica L. aqueous extract (FCAE) on delayed gastric emptying and ulcerative colitis-improved motility disturbances in dextran sulfate sodium (DSS)-induced acute colitis in rats...
June 2, 2018: Journal of Ethnopharmacology
Rapat Pittayanon, Myriam Martel, Alan Barkun
BACKGROUND: Currently, it is still unclear whether adding a mucoprotective agent to a Proton Pump Inhibitor (PPI) results in better outcomes compared to using a PPI alone in patients with post-gastric endoscopic submucosal dissection (ESD) ulcers. This study aimed to examine the efficacy of PPI alone versus combination treatment in healing of post-gastric ESD ulcers, as well as on delayed bleeding and amount of blood transfused. METHODS: A systematic search of MEDLINE, EMBASE, Cochrane, and ISI Web of knowledge databases, up until May 2017, for randomized trials comparing PPI alone versus PPI plus a mucoprotective drug in achieving ulcer healing in patients undergoing gastric ESD was performed...
June 5, 2018: Journal of Gastroenterology and Hepatology
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