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https://www.readbyqxmd.com/read/29226586/protective-effect-of-gentiopicroside-from-gentiana-macrophylla-pall-in-ethanol-induced-gastric-mucosal-injury-in-mice
#1
Yang Yang, Ziye Wang, Li Zhang, Bing Yin, Le Lv, Jiao He, Ziyang Chen, Xin Wen, Boling Qiao, Wenji Sun, Minfeng Fang, Yongmin Zhang
Gentiopicroside isolated from gentiana macrophylla Pall. belongs to iridoid glycosides. This study aimed to evaluate the protective effect of gentiopicroside against ethanol-induced gastric mucosal injury in mice. Mice were proactively administrated with gentiopicroside by intragastric administration once a day for 3 consecutive days. On the 3rd day, gastric ulcer in mice was induced with 70% ethanol after the last intragastric administration. The stomach tissues were submitted for evaluation of the severity of gastric mucosal alterations...
December 11, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29223540/protective-effect-of-coptisine-free-base-on-indomethacin-induced-gastric-ulcers-in-rats-characterization-of-potential-molecular-mechanisms
#2
Chaodan Luo, Hanbin Chen, Yongfu Wang, Guosheng Lin, Cailan Li, Lihua Tan, Ziren Su, Xiaoping Lai, Jianhui Xie, Huifang Zeng
AIMS: The aim of this study was to comparatively investigate the potential gastroprotective effect and underlying mechanisms of coptisine free base (CFB, 8-hydroxy-7, 8-dihydrocoptisine), berberine and lansoprazole against indomethacin-induced gastric ulcer in rats. MATERIALS AND METHODS: CFB (10, 20 and 40mg/kg), berberine (20mg/kg) and lansoprazole (30mg/kg) were orally administrated to rats prior to indometacin ingestion, and gastric lesions were evaluated macroscopically and histologically, and further analyzed by ELISA, qRT-PCR and Western blot...
December 6, 2017: Life Sciences
https://www.readbyqxmd.com/read/29223380/large-intramural-hematoma-and-gastric-ulcer-after-emr-of-a-small-gastric-polyp
#3
Jonathan Teh, Thinesh Lee Krishnamoorthy, Lim Chee Hooi, Ravishankar Asokkumar
No abstract text is available yet for this article.
December 6, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29222687/chrysophyllum-cainito-apple-star-a-fruit-with-gastroprotective-activity-in-experimental-ulcer-models
#4
Roseane Leandra da Rosa, Camila Leandra de Almeida, Lincon Bordigon Somensi, Thaise Boeing, Luisa Nathália Bolda Mariano, Clarissa de Medeiros Amorim Krueger, Priscila de Souza, Valdir Cechinel Filho, Luisa Mota da Silva, Sérgio Faloni de Andrade
The gastroprotective potential of the methanolic extracts from peels (MEPe), seeds (MESe) and pulp (MEPu) of Chrysophyllum cainito L. (Sapotaceae) fruits was evaluated in mice using ethanol/HCl- and indomethacin-induced ulcer, as well as the antiulcer effect of the juice and flour from this fruit. The lowest oral gastroprotective dose of MEPe, MESe and MEPu against ethanol/HCl was 3, 3 and 10 mg/kg, respectively. Moreover, all extracts increased mucin secretion at 176, 198 and 193%. Intraperitoneal administration of MEPe (0...
December 8, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/29222587/gastrointestinal-manifestation-of-immunoglobulin-g4-related-disease-clarification-through-a-multicenter-survey
#5
Kenji Notohara, Terumi Kamisawa, Kazushige Uchida, Yoh Zen, Mitsuhiro Kawano, Satomi Kasashima, Yasuharu Sato, Masahiro Shiokawa, Takeshi Uehara, Hajime Yoshifuji, Hiroko Hayashi, Koichi Inoue, Keisuke Iwasaki, Hiroo Kawano, Hiroyuki Matsubayashi, Yukitoshi Moritani, Katsuhiko Murakawa, Yoshio Oka, Masatoshi Tateno, Kazuichi Okazaki, Tsutomu Chiba
BACKGROUND: Several reports on immunoglobulin (Ig)G4-related disease (IgG4-RD) with gastrointestinal involvement (IgG4-related gastrointestinal disease; IgG4-GID) have been published, although this entity has not been fully established clinicopathologically. Thus, we carried out a multicenter survey. METHODS: Patients with possible IgG4-GID who underwent resection were collected. Histologic slides were reevaluated, and eight cases with diffuse lymphoplasmacytic infiltration but without numerous neutrophils, granulations or epithelioid granulomas were further analyzed...
December 8, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29222050/effects-of-the-rna-binding-protein-ksrp-on-innate-immune-response-against-helicobacter-pylori-infection-in-mice
#6
Ningzhe Li, Mei Cao, Sijun Yi, Juan Cheng, Lei Wang, Yuwei Tao, Daoyan Wu, Jingshan Peng, Mao Zhang, Panpan Qi, Jian Zhao
Helicobacter pylori (H. pylori) contributes to various gastric diseases such as chronic gastritis, gastric ulcer, and gastric carcinoma. Host innate immune response against the pathogen plays a significant role in elimination of pathogen infection. Importantly, pathogen elimination is closely related to numerous inflammatory-related genes that participate in complex biological response of cells to harmful stimuli. Here we studied effects of the KH-type splicing regulatory protein (KSRP), a RNA-binding protein, on innate immune response against H...
December 5, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29220339/to-flavor-or-not-to-flavor-extemporaneous-omeprazole-liquid
#7
Monica C Chuong, Catherine A Taglieri, Stephen G Kerr
Omeprazole is a proton pump inhibitor used to treat the symptoms of gastro esophageal reflux disease, ulcers, excess stomach acid, infection with Helicobacter pylori, and to control the gastric side effects of various drugs. The approved dosage forms in the U.S. are powder in compounding kits, delayed-release granules for oral suspension, oral delayed-release tablets, and oral delayed-release capsules. An extemporaneously compounded unsweetened oral liquid method, published in the International Journal of Pharmaceutical Compounding, was found to be commonly used by pharmacists...
November 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29219812/helicobacter-pylori-resistance-in-the-netherlands-a-growing-problem
#8
R Ruiter, H F Wunderink, R A Veenendaal, L G Visser, M G J de Boer
Helicobacter pylori infection is clinically associated with dyspepsia, gastric and duodenal ulcers, and gastric cancer. Increasing antimicrobial resistance in H. pylori is a worldwide problem and failure of eradication with standard triple therapy (high-dose proton pump inhibition, amoxicillin and clarithromycin) is directly related to the presence of a resistant strain. Other treatment combinations have been investigated, but with inconsistent results. Based on a review of the recent literature in conjunction with an analysis of the regional resistance data, we address the increasing complexity of H...
November 2017: Netherlands Journal of Medicine
https://www.readbyqxmd.com/read/29216727/effect-of-egf-on-bax-bcl-2-and-fas-expression-in-ulcerous-disease-and-n87-cell-line
#9
F Soylemez, O I Ay, E Ay, E Altintas, C H Turkseven, M E Erdal
BACKGROUND: To evaluate the effect of epithelial growth factor (EGF) in primary culture of ulcer patients and N87 cell line on expressions of apoptotic genes. METHODS: Ulcer patients who attended Gastroenterology Clinic of Mersin University Medical Faculty were included in this study. Three different doses of EGF were applied to the primary culture of biopsy samples from ulcer patients and gastric cancer cell-line (ATCC-NCI-N87) . The expression levels of Bax, Bcl-2 and Fas genes were measured with quantitative real-time PCR (qRT-PCR)...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29216438/antiulcerative-activity-of-milk-proteins-hydrolysates
#10
Wilman Carrillo, Karin Maia Monteiro, Daniel Martínez-Maqueda, Mercedes Ramos, Isidra Recio, João Ernesto de Carvalho
Several studies have shown the protective effect of dairy products, especially α-lactalbumin and derived hydrolysates, against induced gastric ulcerative lesions. The mucus strengthening represents an important mechanism in the defense of gastrointestinal mucosa. Previously, a hydrolysate from casein (CNH) and a hydrolysate from whey protein concentrate rich in β-lactoglobulin (WPH) demonstrated a stimulatory activity on mucus production in intestinal goblet cells. The aim of this work was to evaluate the possible antiulcerative activity of these two hydrolysates in an ethanol-induced ulcer model in rats...
December 7, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29214885/short-term-efficacy-of-potassium-competitive-acid-blocker-following-gastric-endoscopic-submucosal-dissection-a-propensity-score-analysis
#11
Yohei Horikawa, Hiroya Mizutamari, Nobuya Mimori, Yuhei Kato, Saki Fushimi, Sayaka Sato, Syunji Okubo
BACKGROUND: Endoscopic submucosal dissection (ESD) is a promising method for the resection of superficial gastric neoplasms. Vonoprazan is a novel potassium-competitive acid blocker (P-CAB) that is currently considered as a potential alternative to proton pump inhibitors (PPIs) for the treatment of acid-related diseases. However, the utility of vonoprazan in ESD-related ulcers is unclear. Therefore, we compared the short-term efficacies of vonoprazan and the PPI lansoprazole in ESD-related ulcer healing during the first two weeks following intervention...
December 7, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29213351/spondias-purpurea-l-anacardiaceae-antioxidant-and-antiulcer-activities-of-the-leaf-hexane-extract
#12
Cynthia Layse Ferreira de Almeida, Samara Alves Brito, Temístocles Italo de Santana, Henrique Bandeira Alves Costa, Carlson Helder Reis de Carvalho Júnior, Márcia Vanusa da Silva, Lécio Leone de Almeida, Larissa Araújo Rolim, Vanda Lucia Dos Santos, Almir Gonçalves Wanderley, Teresinha Gonçalves da Silva
Spondias purpurea is used in folk medicine to treat diarrhea and diuresis. The objective of this study was to evaluate the phytochemical profile and antioxidant and antiulcer activities of the hexane extract of the leaves of S. purpurea (SpHE). Phytochemical profile was evaluated via thin layer chromatography (TLC) and HPLC. SpHE was screened for antioxidant activities using DPPH, ABTS, FRAP, and phosphomolybdenum assays. To determine its antiulcer properties, animals were pretreated with injured control, lansoprazole, ranitidine, carbenoxolone, or SpHE (12...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29212871/gastric-liposarcoma-resected-by-laparoscopic-total-gastrectomy-to-achieve-a-wide-surgical-margin
#13
Katsuhiro Tomofuji, Jota Watanabe, Naoki Ishida, Shinsuke Kajiwara
Gastric liposarcoma is an extremely rare tumour that usually affects the extremities and retroperitoneum. Preoperative diagnosis is difficult, and operative procedures are not well standardised. A 61-year-old woman presented with melaena, epigastric discomfort and palpitations. Upper endoscopy revealed a submucosal tumour at the posterior gastric fundus with an actively bleeding ulcer on the top. Our preoperative diagnosis was lipoma, and we performed laparoscopic intragastric surgery. However, the histopathological diagnosis was liposarcoma...
December 5, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29212832/adenosine-a-2a-receptor-agonist-2-p-2-carboxyethyl-phenethylamino-5-n-ethylcarboxamidoadenosine-hydrochloride-hydrate-cgs21680-inhibits-inflammation-and-increases-fibroblast-growth-factor-2-fgf-2-tissue-expression-in-carrageenan-induced-rat-paw-edema
#14
Armando Ialenti, Elisabetta Caiazzo, Silvana Morello, Rosa Carnuccio, Carla Cicala
Adenosine is the final product of ATP metabolism, mainly derived from the action of 5'-nucleotidase cleavage of AMP. Cellular production of adenosine is greatly enhanced in inflamed tissues, ischemic tissues and under hypoxia, where ATP is released from damaged cells. Much evidence has been accumulated on adenosine antinflammatory effects mediated through A 2A receptor activation; A2A adenosine receptor has also been shown to play a role in matrix deposition and wound healing in a damaged tissue, contributing to dermal tissue protection and repair...
December 6, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29212068/activation-of-secretagogue-independent-gastric-acid-secretion-via-endothelial-nitric-oxide-synthase-stimulation-in-rats
#15
Alice Miriam Kitay, Alexander Link, John P Geibel
BACKGROUND/AIMS: L-arginine is an important mediator of cell division, wound healing, and immune function. It can be transformed by the nitric oxide synthase (NOS) to nitric oxide (NO), an important cell signaling molecule. Recent studies from our laboratory demonstrate specific effects of L-arginine (10mM) exposure on gastric acid secretion in rat parietal cells. METHODS: Studies were performed with isolated gastric glands and the pH sensitive dye BCECF-AM +/- L-arginine to examine its effects on acid secretion...
December 6, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29211362/clinical-differences-of-helicobacter-pylori-infection-in-children
#16
REVIEW
Barbara M Iwańczak, Anna M Buchner, Franciszek Iwańczak
Helicobacter pylori infection is widely spread all over the world. The prevalence of H. pylori infection in the world varies and depends on numerous factors such as age, ethnicity, geographical and socioeconomic status. Humans have been in a symbiotic relationship with this bacterium for thousands of years. However 10-20% of people infected with H. pylori are likely to develop gastroduodenal diseases such as peptic ulcer disease, iron deficiency anemia, gastric mucosal atrophy, metaplasia, dysplasia, MALT lymphoma, or gastric adenocarcinoma...
October 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29210527/seroprevalence-of-helicobacter-pylori-in-hispanics-living-in-puerto-rico-a-population-based-study
#17
María González-Pons, Marievelisse Soto-Salgado, Javier Sevilla, Juan M Márquez-Lespier, Douglas Morgan, Cynthia M Pérez, Marcia Cruz-Correa
BACKGROUND: Helicobacter pylori is an important etiologic factor for peptic ulcers and gastric cancer, one of the top ten leading causes of cancer death in Puerto Rico. However, the prevalence of H. pylori infections in this population was previously unknown. The aim of this study was to examine the seroprevalence of H. pylori and its associated risk factors in Puerto Rico. MATERIALS AND METHODS: A cross-sectional study was designed using an existing population-based biorepository...
December 6, 2017: Helicobacter
https://www.readbyqxmd.com/read/29209743/gastroprotective-activity-of-the-methanol-extract-from-peels-of-plinia-edulis-vell-sobral-fruits-and-its-isolated-triterpenes-maslinic-and-ursolic-acids
#18
Roseane Leandra da Rosa, Luciane Ângela Nottar Nesello, Luisa Nathalia Bolda Mariano, Lincon Bordignon Somensi, Adriana Campos, Ana Myrelle Pinheiro, Sabrina Costa, Marjana Rial, Mariana Tozzo, Valdir Cechinel-Filho, Sérgio Faloni de Andrade, Luísa Mota Da Silva
According to the Brazilian folk medicine, the leaves of Plinia edulis (Vell.) Sobral (Myrtaceae), known as cambuca, are indicated in the treatment of gastric disorders. Infusions of P. edulis leaves were previously demonstrated to contain both maslinic (MA) and ursolic acids (UA). Both triterpenes have also been identified in the methanolic extract of peels from P. edulis fruit (MEPPE); however, the antiulcer effects of MEPPE have not yet been studied. This study therefore evaluates the gastroprotective potential of MEPPE, MA, and UA using ethanol/HCl- and indomethacin-induced gastric ulcers in mice...
December 5, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29208798/a-clinical-and-microbiological-evaluation-of-helicobacter-pylori-in-recurrent-aphthous-stomatitis
#19
Kamala Rajendra, Sadananda M Purnachandra, Parthkumar C Patel, Jochima Cota, Venkat R Singh, Ankur Vatsal
AIM: The aim of this study is to evaluate the association of Helicobacter pylori in recurrent aphthous stomatitis (RAS) with or without peptic ulcer. MATERIALS AND METHODS: A total of 42 patients were selected for the present study from outpatient Department of Oral Medicine, and divided into control (group I) and test groups (groups II, III). A total number of 15 patients suffering from RAS based on history and clinical examination was selected as group II. A total number of 12 patients suffering concomitantly from RAS and duodenal ulcer based on history and clinical examination were selected as group III...
December 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/29205834/validation-of-alcohol-flushing-questionnaires-in-determining-inactive-aldehyde-dehydrogenase-2-and-its-clinical-implication-in-alcohol-related-diseases
#20
Cheol Min Shin, Nayoung Kim, Sung-Il Cho, Joohon Sung, Hee-Jung Lee
BACKGROUND: To validate alcohol flushing questionnaires in detecting inactive ALDH2 (ALDH2*1/*2 or ALDH2*2/*2). METHODS: Two study sets were established; in study set 1, 210 healthy male subjects (age, 21-59 years) were enrolled; in the study set 2, 756 subjects were enrolled who received esophagogastroduodenoscopy to evaluate their dyspeptic symptoms or as a part of a gastric cancer screening program. Subjects in study set 1 and study set 2 completed modified alcohol flushing questionnaires of the Yokoyama et al (1997) and Yokoyama et al (2003), respectively...
December 5, 2017: Alcoholism, Clinical and Experimental Research
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