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Melanocytic nevi

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https://www.readbyqxmd.com/read/28628691/eruptive-melanocytic-acral-nevi-in-the-setting-of-6-mercaptopurine-therapy
#1
Arpan V Prabhu, Kristin Bibee, Joseph C English
<p>Eruptive melanocytic nevi (EMN) are a rare clinical finding characterized by sudden-onset nevi that often present in a grouped distribution. They have been associated with chemotherapy, immunosuppression, bullous diseases, and medications including multikinase and BRAF inhibitors. It is important for dermatologists to be able to identify patients with sudden development of new melanocytic nevi secondary to particular medications. Herein, we describe a case of eruptive melanocytic acral nevi secondary to 6-mercaptopurine therapy...
May 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28614272/quantification-of-microrna-21-and-microrna-125b-in-melanoma-tissue
#2
Anne Wandler, Rikke Riber-Hansen, Henrik Hager, Stephen J Hamilton-Dutoit, Henrik Schmidt, Boye S Nielsen, Magnus Stougaard, Torben Steiniche
Although microRNAs (miRNAs) have emerged as potent mediators of melanoma development and progression, a precise understanding of their oncogenic role remains unclear. In this study, we analysed formalin-fixed and paraffin-embedded tissues from two separate melanoma cohorts and from a series of benign melanocytic nevi. Using three different quantification methods [array analysis, quantitative PCR (qPCR) and in-situ hybridization (ISH) quantified by digital image analysis], we found considerable miRNA dysregulation in tumours...
June 13, 2017: Melanoma Research
https://www.readbyqxmd.com/read/28604751/melanocytic-nevi-and-melanoma-unraveling-a-complex-relationship
#3
REVIEW
W E Damsky, M Bosenberg
Approximately 33% of melanomas are derived directly from benign, melanocytic nevi. Despite this, the vast majority of melanocytic nevi, which typically form as a result of BRAF(V600E)-activating mutations, will never progress to melanoma. Herein, we synthesize basic scientific insights and data from mouse models with common observations from clinical practice to comprehensively review melanocytic nevus biology. In particular, we focus on the mechanisms by which growth arrest is established after BRAF(V600E) mutation...
June 12, 2017: Oncogene
https://www.readbyqxmd.com/read/28601392/histopathologic-features-of-melanoma-in-difficult-to-diagnose-lesions-a-case-control-study
#4
Manuel Lora Gonzalez, Eric D Young, James Bush, Katelyn McKenzie, Edgar Hunt, Viseslav Tonkovic-Capin, Melissa Jacobs, Michael Kucenic, Garth R Fraga
BACKGROUND: Dermatopathology is considered the gold standard for melanoma diagnosis, but a subset of cases is difficult to diagnose by histopathology. OBJECTIVE: The goals of this study were to measure the accuracy of histopathologic features in difficult-to-diagnose melanocytic tumors and the interobserver agreement of those features. METHODS: This is a case-control study of histopathologic features of melanoma in 100 difficult-to-diagnose melanocytic neoplasms (40 melanomas and 60 nevi)...
June 7, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28591278/comparisons-of-choroidal-nevus-measurements-obtained-using-10-and-20-mhz-ultrasound-and-spectral-domain-optical-coherence-tomography
#5
Maíra de França Martins, Kelcia Kiefer, Liliane Almeida Andrade Kanecadan, Patricia Novita Garcia, Rubens N Belfort, Norma Allemann
Purpose: To compare measurements of lesions clinically diagnosed as choroidal nevi using spectral domain optical coherence tomography (SD-OCT) and 10- and 20-MHz ultrasound (US). Methods: This prospective study, which was conducted between May 2011 and December 2011, evaluated eyes diagnosed with choroidal nevus via photographic documentation using 10- or 20-MHz A- and B-mode US (experienced examiner using both the transpalpebral technique and direct contact) or SD-OCT in the enhanced depth imaging mode (performed by a different examiner blinded to the US results)...
March 2017: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/28581514/aldh1a3-is-epigenetically-regulated-during-melanocyte-transformation-and-is-a-target-for-melanoma-treatment
#6
M Pérez-Alea, K McGrail, S Sánchez-Redondo, B Ferrer, G Fournet, J Cortés, E Muñoz, J Hernandez-Losa, S Tenbaum, G Martin, R Costello, I Ceylan, V Garcia-Patos, J A Recio
Despite the promising targeted and immune-based interventions in melanoma treatment, long-lasting responses are limited. Melanoma cells present an aberrant redox state that leads to the production of toxic aldehydes that must be converted into less reactive molecules. Targeting the detoxification machinery constitutes a novel therapeutic avenue for melanoma. Here, using 56 cell lines representing nine different tumor types, we demonstrate that melanoma cells exhibit a strong correlation between reactive oxygen species amounts and aldehyde dehydrogenase 1 (ALDH1) activity...
June 5, 2017: Oncogene
https://www.readbyqxmd.com/read/28565919/age-and-anatomical-location-related-dermoscopic-patterns-of-210-acral-melanocytic-nevi-in-a-turkish-population
#7
Nazan Emiroglu, Fatma Pelin Cengiz, Nahide Onsun
BACKGROUND: Dermoscopy is a useful tool for earlier diagnosis and differentiating benign lesions from melanoma. OBJECTIVES: We aim to investigate dermoscopic features of acral nevi, age, and localisation-related findings of these lesions. METHODS: This was an observational, descriptive study. Patients were retrospectively collected from the Department of Dermatology. The patients with acral nevi were included in the study. Inclusion criteria were Turkish nationality and the presence of at least 1 acral nevus diagnosed both clinically and dermoscopically...
May 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28543606/reflectance-confocal-microscopy-analysis-of-equivocal-melanocytic-lesions-with-severe-regression
#8
M Agozzino, A Ferrari, C Cota, C Franceschini, P Buccini, L Eibenshutz, M Ardigò
BACKGROUND: The differential diagnosis between regressing nevi and melanoma might be challenging; regressing areas can represent a confounding factor for the diagnosis and the histology still remain mandatory to rule out melanoma. Reflectance confocal microscopy may add valuable information by revealing features suggestive of the nature of the melanocytic proliferation. OBJECTIVE: To assess the impact of confocal microscopy in the management of regressive melanocytic lesions...
May 21, 2017: Skin Research and Technology
https://www.readbyqxmd.com/read/28538892/giant-congenital-melanocytic-nevi-40-years-of-experience-with-the-serial-excision-technique
#9
Lais de Abreu Mutti, Marta Regina Machado Mascarenhas, João Marcos Goes de Paiva, Ronaldo Golcman, Mauro Yoshiaki Enokihara, Benjamin Golcman
Although giant congenital melanocytic nevus is a rare lesion, it causes significant deformity and carries a risk of malignant degeneration. Different surgical techniques for the lesion removal are described, including serial resection, resection with skin grafting, and resection and coverage with expanded skin flap (skin expanders). The aim of this study is to report the author's 40 years of experience with cases requiring at least 4 serial excisions to complete the treatment. Serial resection is an effective, safe, and simple technique that requires a lot of patience...
March 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28538885/proliferative-nodule-in-melanocytic-nevi-mimicking-deep-penetrating-nevus
#10
Ana Almodovar-Real, Alejandro Molina-Leyva, Jose Aneiros-Fernandez, Miguel Antonio Diaz-Martinez
Proliferative nodules can occasionally arise on congenital and acquired melanocytic nevi. At first sight their clinical and pathologic features cause alert to both dermatologist and dermatopathologist. However, proliferative nodules are typically benign, regression is common and there is minimum risk of malignization. We present a new case of proliferative nodule in melanocytic nevi with features of deep penetrating nevus.
March 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28538879/a-prospective-study-of-patients-with-large-congenital-melanocytic-nevi-and-the-risk-of-melanoma
#11
Ana Carolina Leite Viana, Eugênio Marcos Andrade Goulart, Bernardo Gontijo, Flávia Vasques Bittencourt
Background: Large congenital melanocytic nevus (LCMN) is considered a risk factor for melanoma, although the magnitude of this risk is controversial. Objective: To evaluate the risk of melanoma development in patients with LCMN seen at a dermatology referral center in Brazil during a twelve-year period. To the best of our knowledge, there are no published similar studies on large congenital melanocytic nevus in South America. Methods: Our prospective cohort included only patients with congenital nevi ≥20cm...
March 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28535637/-analysis-of-prodromal-phase-and-prodromal-events-in-anti-n-methyl-d-aspartate-receptor-encephalitis
#12
Y Yao, B Peng, X H Wang, F Fang, D Xu, X L Xu, H T Ren, Y C Zhu, L Y Cui, H Z Guan
Objective: To analyze prodromal phase and prodromal events of anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis. Methods: Clinical data of 179 patients hospitalized and diagnosed during 2010-2016 including adults and children in Peking Union Medical College Hospital and Beijing Children's Hospital were collected.Patients with prodromal phase or prodromal events were selected.A retrospective analysis of clinical characteristics including prodromal phase or prodromal events, course of disease, brain imaging, laboratory results and therapeutic effect was performed...
May 23, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28528541/melanoma-frequency-among-symmetrical-spitzoid-looking-lesions-a-retrospective-study
#13
Claudia Costa, Matteo Megna, Milena Cappello, Maddalena Napolitano, Giuseppe Monfrecola, Massimiliano Scalvenzi
BACKGROUND: Many efforts have been spent attempting to define clinical, histopathological and molecular markers for differential diagnosis of Spitz nevus and melanoma. Dermoscopy has been widely used but it may be not always sufficient. METHODS: A retrospective study was performed evaluating Spitzoid-looking lesions showing symmetry at clinical and dermoscopic examination in patients ≥ 12 years attending our Clinic from 2004 to 2014. Demographic, clinical and dermoscopic data were assessed for each lesion in order to highlight the most common characteristics which could help the differential diagnosis between Spitz nevus and melanoma when clinical or dermoscopic asymmetry is lacking...
May 16, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28524047/oestrogen-and-progesterone-receptor-in-melanoma-and-nevi-an-immunohistochemical-study
#14
Emi Dika, Pier Alessandro Fanti, Sabina Vaccari, Elisa Capizzi, Alessio Degiovanni, Agnese Gobbi, Bianca Maria Piraccini, Simone Ribero, Carlotta Baraldi, Giulia Maria Ravaioli, Michelangelo Fiorentino, Annalisa Patrizi
The effect of hormonal stimulation and fertility treatments, as well as their role in the development of malignant melanoma (MM), is still to be determined. The aim of this study was to investigate the presence of oestrogen receptor alpha (ERα) and progesterone receptor (PR) in MM and nevi after hormonal stimulation. Immunohistochemical analyses were performed utilizing antibodies specifically directed against ERα and PR in MM and atypical nevi specimens from patients: (1) diagnosed during pregnancy, (2) diagnosed in the six months following delivery, or (3) who had undergone repetitive cycles of hormonal stimulation for in vitro fertilization in the year that preceded MM diagnosis...
May 19, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/28509525/melanoma-frequency-among-symmetrical-spitzoid-looking-lesions-a-retrospective-study
#15
Claudia Costa, Matteo Megna, Milena Cappello, Maddalena Napolitano, Giuseppe Monfrecola, Massimiliano Scalvenzi
BACKGROUND: Many efforts have been spent attempting to define clinical, histopathological and molecular markers for differential diagnosis of Spitz nevus and melanoma. Dermoscopy has been widely used but it may be not always sufficient. METHODS: A retrospective study was performed evaluating Spitzoid-looking lesions showing symmetry at clinical and dermoscopic examination in patients ≥ 12 years attending our Clinic from 2004 to 2014. Demographic, clinical and dermoscopic data were assessed for each lesion in order to highlight the most common characteristics which could help the differential diagnosis between Spitz nevus and melanoma when clinical or dermoscopic asymmetry is lacking...
May 16, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28508099/giant-congenital-melanocytic-nevi-and-malignant-transformation-a-case-for-early-radical-intervention
#16
Christopher R Maguire, Ryan Livingston, Gael E Phillips, Roy M Kimble
The purpose of this paper is to highlight the risk of early malignant transformation in infants with giant congenital melanocytic nevi (GN) and demonstrate the potential for earlier intervention with aggressive surgery. We describe the case of a child born with a GN who developed a metastatic melanoma early in life, despite early commencement of resection of the nevus. This is contrasted against a second case of a child in which a more radical management was conducted. Despite early commencement of serial resection of the GN, the first child in this series died of metastatic melanoma prior to complete excision of the nevus...
May 15, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/28504086/drug-induced-eruptive-melanocytic-nevi
#17
P García-Montero, J F Millán-Cayetano, C García-Harana, J Del Boz
No abstract text is available yet for this article.
May 11, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28492864/induction-of-immune-reaction-in-benign-melanocytic-nevi-without-halo-during-nivolumab-therapy-in-a-patient-with-melanoma
#18
Yasuhiro Nakamura, Takashi Fujino, Hiroshi Kagamu, Taisuke Matsuya, Yukiko Teramoto, Yuri Asami, Akifumi Yamamoto
No abstract text is available yet for this article.
May 10, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28492593/eruptive-melanocytic-nevi-during-azathioprine-therapy-for-antisynthetase-syndrome
#19
Stephanie A Steinweg, Christian R Halvorson, Grace F Kao, Sridhar Dronavalli
Eruptive melanocytic nevi (EMN) are rare multiple benign melanocytic nevi that develop within a few months. The phenomenon has been associated with a variety of dermatologic and systemic conditions, including Stevens-Johnson syndrome, toxic epidermal necrolysis, epidermolysis bullosa, Addison disease, human immunodeficiency virus infection, and internal malignancy, among others. It also is commonly attributed to medications, particularly immunosuppressive and chemotherapeutic agents. We report a case of EMN in a 50-year-old man undergoing azathioprine therapy for antisynthetase syndrome...
April 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28481878/the-ap-1-transcription-factor-fosl1-causes-melanocyte-reprogramming-and-transformation
#20
K Maurus, A Hufnagel, F Geiger, S Graf, C Berking, A Heinemann, A Paschen, S Kneitz, C Stigloher, E Geissinger, C Otto, A Bosserhoff, M Schartl, S Meierjohann
The MAPK pathway is activated in the majority of melanomas and is the target of therapeutic approaches. Under normal conditions, it initiates the so-called immediate early response, which encompasses the transient transcription of several genes belonging to the AP-1 transcription factor family. Under pathological conditions, such as continuous MAPK pathway overactivation due to oncogenic alterations occurring in melanoma, these genes are constitutively expressed. The consequences of a permanent expression of these genes are largely unknown...
May 8, 2017: Oncogene
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