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Melanocytic nevi

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https://www.readbyqxmd.com/read/27926791/high-prevalence-of-mitf-staining-in-undifferentiated-pleomorphic-sarcoma-caution-in-use-of-melanocytic-markers-in-sarcoma
#1
Bonnie Choy, Elizabeth Hyjek, Anthony G Montag, Peter Pytel, Rex Haydon, Hue H Luu, Chao Jie Zhen, Bradley C Long, Sabah Kadri, Jeremy P Segal, Larissa V Furtado, Nicole A Cipriani
AIMS: Diagnosis of undifferentiated pleomorphic sarcoma (UPS) may be challenging, as other lesions with undifferentiated spindle cell morphology must be excluded, including melanoma. Microphthalmia-associated transcription factor (MiTF) stains nevi and epithelioid melanomas, as well as some mesenchymal neoplasms. We evaluated the prevalence of MiTF and melanocytic markers in UPS and a subset of atypical fibroxanthoma (AFX). METHODS AND RESULTS: MiTF, SOX10, Melan-A, HMB45, and S100 immunostains were performed on resection specimens from 19 UPS and 5 AFX...
December 7, 2016: Histopathology
https://www.readbyqxmd.com/read/27926637/pigmentation-and-pregnancy-knowing-what-is-normal
#2
Amy Kalowitz Bieber, Kathryn J Martires, Jennifer A Stein, Jane M Grant-Kels, Marcia S Driscoll, Miriam Keltz Pomeranz
Changes in melanocytic nevi during pregnancy are frequently attributed to the new hormonal milieu and are dismissed without concern for malignancy. Recent studies suggest that pregnancy itself does not induce significant change in nevi, and delays in the assessment of changing moles may contribute to the often more advanced nature of melanomas diagnosed during or soon after pregnancy. Nevi on the breasts and abdomen can grow as a result of skin expansion, but studies have found no significant changes in nevi located in more stable areas such as the back or lower extremities...
December 2, 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27920018/a-phase-ii-randomized-placebo-controlled-trial-of-oral-n-acetylcysteine-for-protection-of-melanocytic-nevi-against-uv-induced-oxidative-stress-in-vivo
#3
Pamela B Cassidy, Tong Liu, Scott R Florell, Matthew Honeggar, Sancy A Leachman, Kenneth M Boucher, Douglas Grossman
Oxidative stress plays a role in UV-induced melanoma, which may arise from melanocytic nevi. We investigated whether oral administration of the antioxidant N-acetylcysteine (NAC) could protect nevi from oxidative stress in vivo in the setting of acute UV exposure. The minimal erythemal dose (MED) was determined for 100 patients at increased risk for melanoma. Patients were randomized to receive a single dose (1,200 mg) of NAC or placebo, in double-blind fashion, and then one nevus was irradiated (1-2 MED) using a solar simulator...
December 5, 2016: Cancer Prevention Research
https://www.readbyqxmd.com/read/27917515/associations-between-benign-cutaneous-nevi-and-risk-of-type-2-diabetes-mellitus-in-men-and-women-results-from-two-prospective-cohort-studies
#4
H Dai, Q Sun, C Zhang, X Zhang, W-Q Li, J E Manson, F B Hu, Y Song
AIM: To examine the association of cutaneous nevi with Type 2 diabetes risk. METHODS: We prospectivly examined the associations between nevus count and risk of Type 2 diabetes among 26 240 men (1988-2010) from the Health Professionals Follow-up Study and 67 050 women (1986-2010) from the Nurses' Health Study. Information on the numbers of cutaneous nevi on arms at baseline and incident cases of Type 2 diabetes was collected using validated questionnaires. RESULTS: During 1 879 287 person-years of follow-up, we documented 9040 incident cases of Type 2 diabetes...
December 5, 2016: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/27916254/pigmented-oral-compound-nevus-of-retromolar-area-a-rare-case-report
#5
Virender Gombra, Mandeep Kaur, Keya Sircar, Deepika Bablani Popli
Solitary pigmented melanocytic intraoral lesions of the oral cavity are rare. Oral nevus is a congenital or acquired benign neoplasm. Oral compound nevus constitutes 5.9%-16.5% of all oral melanocytic nevi. The oral compound nevus is commonly seen on hard palate and buccal mucosa and rarely on other intraoral sites. The objective of this article is to present a rare case report of oral compound nevus in the retromolar pad region along with a review of literature. A 22 year old female reported with a solitary black pigmented papule at retromolar pad region which was surgically removed and microscopic investigation confirmed the diagnosis of oral compound nevus...
December 2016: Singapore Dental Journal
https://www.readbyqxmd.com/read/27904284/eruptive-benign-melanocytic-nevi-formation-following-adalimumab-therapy-in-a-patient-with-crohn-s-disease
#6
Ik Jun Moon, Chong Hyun Won, Mi Woo Lee, Jee Ho Choi, Sung Eun Chang
No abstract text is available yet for this article.
December 2016: Annals of Dermatology
https://www.readbyqxmd.com/read/27904187/the-relationship-of-psoriasis-and-melanocytic-nevi
#7
Fatma Pelin Cengiz, Nazan Emiroglu, Anil Gulsel Bahali, Dilek Biyik Ozkaya, Ozlem Su, Nahide Onsun
BACKGROUND: There is limited data about the relationship between psoriasis and melanocytic lesions and melanoma. Immunologic pathways which were implicated in psoriasis induce a reduction in the number of melanocytic nevi. AIMS AND OBJECTIVES: To investigate the number of melanocytic nevi in psoriatic patients compared with controls and its relationship with disease severity and type of treatment. METHODS: We performed a prospective study in 100 psoriatic patients and 100 controls...
November 2016: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/27899968/prognostic-significance-of-the-expression-of-nuclear-eukaryotic-translation-initiation-factor-5a2-in-human-melanoma
#8
Shahram Khosravi, Magdalena Martinka, Youwen Zhou, Christopher J Ong
Eukaryotic translation initiation factor 5A2 (EIF5A2) expression is upregulated in various cancers. The present authors previously demonstrated that cytoplasmic EIF5A2 expression increases with melanoma progression and inversely correlates with patient survival. Other studies have suggested that nuclear EIF5A2 may also play a role in oncogenesis. The present study used immunohistochemistry and tissue microarray with a large number of melanocytic lesions (n=459) and demonstrated that nuclear EIF5A2 expression was significantly upregulated between common acquired nevi, dysplastic nevi and primary melanomas, and between primary melanomas and metastatic melanomas...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27895537/tissue-expansion-in-children
#9
REVIEW
Tara L Braun, Kristy L Hamilton, Laura A Monson, Edward P Buchanan, Larry H Hollier
Tissue expansion is a well-established surgical method that has been creatively applied to the management of many congenital and acquired pediatric conditions, including the removal of giant congenital melanocytic nevi and the separation of conjoined twins. Careful preoperative planning and patient follow-up are required to achieve the proper results and minimize complications. Special considerations for pediatric patients are present during each step of the process, from patient selection to postoperative care...
November 2016: Seminars in Plastic Surgery
https://www.readbyqxmd.com/read/27894587/pre-expanded-paraumbilical-perforator-flap
#10
REVIEW
Yuanbo Liu, Mengqing Zang, Shan Zhu, Bo Chen, Qiang Ding
The paraumbilical perforator flap is the first and the most famous perforator flap. Pre-expansion increases the flap dimension and reduces the flap thickness and donor site morbidities, making the paraumbilical perforator flap a more effective option for upper extremity reconstruction. Pre-expanded pedicled paraumbilical perforator flaps can achieve excellent function and aesthetic outcomes in patients with extensive scar contracture and giant melanocytic nevi in the upper extremity. Although this technique requires multiple procures, each operation is relatively simple and has a low complication rate, when properly planned and performed...
January 2017: Clinics in Plastic Surgery
https://www.readbyqxmd.com/read/27894574/an-overview-of-pre-expanded-perforator-flaps-part-2-clinical-applications
#11
REVIEW
Chunmei Wang, Jing Zhang, Hiko Hyakusoku, Ping Song, Lee L Q Pu
Pre-expanded perforator flaps have several advantages over their traditional counterparts owing to the thin, more pliable nature, larger size, and minimum morbidity of the donor site. Recently, plastic surgeons have begun to use pre-expanded perforator flaps to reconstruct defects of almost the entire body, including the cervicofacial region, axilla, trunk, and extremities resulting from scar, congenital melanocytic nevi, hemangiomas, and neurofibromas. Such a versatile flap is especially appropriate for face and neck resurfacing, which requires more optimal functional and cosmetic outcomes...
January 2017: Clinics in Plastic Surgery
https://www.readbyqxmd.com/read/27890785/genomic-characterization-of-dysplastic-nevi-unveils-implications-for-diagnosis-of-melanoma
#12
Rachel D Melamed, Iraz T Aydin, Geena Susan Rajan, Robert Phelps, David N Silvers, Kevin J Emmett, Georg Brunner, Raul Rabadan, Julide Tok Celebi
A well-defined risk factor and precursor for cutaneous melanoma is the dysplastic nevus. These benign tumors represent clonal hyperproliferation of melanocytes that are in a senescent-like state, but with occasional malignant transformation events. To portray the mutational repertoire of dysplastic nevi in patients with the dysplastic nevus syndrome, and to determine the discriminatory profiles of melanocytic nevi (including dysplastic nevi) from melanoma, we sequenced exomes of melanocytic nevi including dysplastic nevi (n = 19), followed by a targeted gene panel (785 genes) characterization of melanocytic nevi (n = 46) and primary melanomas (n = 42)...
November 24, 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27890240/melanocytic-nevi-and-the-genetic-and-epigenetic-control-of-oncogene-induced-senescence
#13
REVIEW
Jennifer M Huang, Ijeuru Chikeka, Thomas J Hornyak
Melanocytic nevi represent benign clonal proliferations of the melanocytes in the skin that usually remain stable in size and behavior or disappear during life. Infrequently, melanocytic nevi undergo malignant transformation to melanoma. Understanding molecular and cellular mechanisms underlying oncogene-induced senescence should help identify pathways underlying melanoma development, leading to the development of new strategies for melanoma prevention and early detection.
January 2017: Dermatologic Clinics
https://www.readbyqxmd.com/read/27886404/adipophilin-expression-in-cutaneous-malignant-melanoma
#14
Masakazu Fujimoto, Ibu Matsuzaki, Yuki Yamamoto, Akihiko Yoshizawa, Kenji Warigaya, Yoshifumi Iwahashi, Fumiyoshi Kojima, Fukumi Furukawa, Shin-Ichi Murata
BACKGROUND: The lipogenic pathway is upregulated in cancer cells, including melanomas. However, the pathological significance of cellular lipids in melanocytic lesions has yet to be determined. In this study, we evaluated intracytoplasmic lipid droplets in melanocytic nevi (MNs) and malignant melanomas via immunohistochemical analysis of adipophilin (ADP), which coats lipid droplets. METHODS: One hundred primary cutaneous melanocytic lesions (33 MNs, 17 melanomas in situ [MIS], and 50 invasive melanomas [IMs]) were immunostained for ADP...
November 25, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27881943/number-and-size-of-acquired-melanocytic-nevi-and-affecting-risk-factors-in-cases-admitted-to-the-dermatology-clinic
#15
Ayşegül Yalçınkaya İyidal, Ülker Gül, Arzu Kılıç
INTRODUCTION: The size and number of acquired melanocytic nevi (AMN) and presence of dysplastic nevi are the leading risk factors that should be recognized in the development of malignant melanoma. AIM: To evaluate AMN and risk factors in the development of AMN in all age groups admitted to a dermatology outpatient clinic. MATERIAL AND METHODS: Four hundred and twelve patients who were admitted to the dermatology outpatient clinic for any dermatological symptom and who accepted to participate in the study were randomly included in the study...
October 2016: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/27874206/spitz-nevi-and-other-spitzoid-neoplasms-in-children-overview-of-incidence-data-and-diagnostic-criteria
#16
REVIEW
Emi Dika, Giulia Maria Ravaioli, Pier Alessandro Fanti, Iria Neri, Annalisa Patrizi
Spitz nevi are benign melanocytic neoplasms characterized by epithelioid or spindle melanocytes or both. In some rare cases their presentation overlaps with the clinical and histopathologic features of malignant melanoma, so a differential diagnosis can be difficult to make. Intermediate forms between Spitz nevi and malignant melanoma, with unpredictable behavior, have been called atypical Spitz tumors. A literature search was performed to review the clinical, dermoscopic, genetic, and histopathologic aspects of spitzoid tumors...
November 22, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27872202/genome-wide-overexpression-screen-identifies-genes-able-to-bypass-p16-mediated-senescence-in-melanoma
#17
Won Jae Lee, Dubravka Škalamera, Mareike Dahmer-Heath, Konstanin Shakhbazov, Max V Ranall, Carly Fox, Duncan Lambie, Alexander J Stevenson, Paul Yaswen, Thomas J Gonda, Brian Gabrielli
Malignant melanomas often arise from nevi, which result from initial oncogene-induced hyperproliferation of melanocytes that are maintained in a CDKN2A/p16-mediated senescent state. Thus, genes that can bypass this senescence barrier are likely to contribute to melanoma development. We have performed a gain-of-function screen of 17,030 lentivirally expressed human open reading frames (ORFs) in a melanoma cell line containing an inducible p16 construct to identify such genes. Genes known to bypass p16-induced senescence arrest, including the human papilloma virus 18 E7 gene (HPV18E7), and genes such as the p16-binding CDK6 with expected functions, as well as panel of novel genes, were identified, including high-mobility group box (HMGB) proteins...
November 21, 2016: Journal of Biomolecular Screening
https://www.readbyqxmd.com/read/27870726/melanocytic-nevi-of-special-sites
#18
Christine S Ahn, Analia Guerra, Omar P Sangüeza
Melanocytic nevi located on specific regions of the body can demonstrate unusual histopathological features such as asymmetry, irregular nesting patterns, pagetoid spread, cytologic atypia, and rarely, mitotic activity. However, despite these features that may raise concern for malignant melanoma, these lesions follow a benign clinical course and do not require intervention. Also known as nevi of special sites or nevi with site-related atypia, these melanocytic nevi were initially described on acral sites and genitalia...
December 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27867738/evaluation-of-electrical-impedance-spectroscopy-as-an-adjunct-to-dermoscopy-in-short-term-monitoring-of-atypical-melanocytic-lesions
#19
Hannah Ceder, Alexandra Sjöholm Hylén, Ann-Marie Wennberg Larkö, John Paoli
BACKGROUND: Early detection of melanoma is vital for treatment outcome and survival. Short-term sequential digital dermoscopic monitoring (ST-SDDM) involves the capture and assessment of dermoscopic images of one or more atypical melanocytic lesions (AMLs), at baseline and after four months, in order to detect early morphologic changes. Electrical impedance spectroscopy (EIS) is a diagnostic tool with high sensitivity for the detection of malignant melanocytic lesions. OBJECTIVES: The aim of this study was to assess whether EIS, in addition to ST-SDDM, could improve the selection of AMLs requiring surgery...
October 2016: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/27862191/significance-of-epidermal-mitoses-in-challenging-melanocytic-proliferations
#20
Eugen C Minca, Steven D Billings, Paul Elson, Michael T Tetzlaff, Aleodor A Andea, Jennifer S Ko
BACKGROUND: Accurate diagnosis of melanoma remains histologically challenging. Dermal mitoses support malignancy, but are only occasionally seen in melanomas. Since melanomagenesis is thought to begin at the dermal-epidermal junction, we investigated the significance of epidermal melanocytic mitoses (EM) in a spectrum of lesions with molecular characterization. METHODS: EM density (EMD) was evaluated in 46 straightforward lesions (24 benign, 22 malignant) and 30 challenging lesions with expert interpretation, fluorescence-in-situ-hybridization, and myPath-score characterization (12 favor-benign, 9 favor-malignant, 9 ambiguous)...
November 15, 2016: Journal of Cutaneous Pathology
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