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Melanocytic nevi

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https://www.readbyqxmd.com/read/29785332/dermoscopic-changes-in-melanocytic-nevi-covered-with-both-opaque-tape-and-sunscreen-cream-during-narrowband-ultraviolet-b-therapy
#1
Derya Ök Kekeç, Nida Kaçar, Işıl Kılınç Karaarslan
Background: Ultraviolet (UV) light may cause dermoscopic changes on melanocytic nevi (MN). Objectives: To investigate the effects of sunscreen cream (SSc) application on dermoscopic changes in MN during narrowband UVB (NBUVB) therapy. Methods: Half of the randomly selected MN in each patient were covered with opaque tape and SSc [SSc(+)], and the rest were covered with only opaque tape [SSc(-)] during NBUVB treatment sessions. Results: More SSc(-) MN displayed dermoscopic changes at end of NBUVB therapy compared to the start of therapy (p=0...
April 2018: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/29785330/dermoscopy-of-a-spark-s-nevus
#2
Giovanni Biondo, Matteo Gnone, Simona Sola, Carlotta Pastorino, Cesare Massone
Spark's nevus is a particular type of melanocytic nevus that on histology shows features of both Spitz's and Clark's nevus. Clinically, it is an asymmetric, irregular, multicolored, pigmented lesion that is not clearly distinguishable from melanoma or dysplastic (Clark's) nevus. Dermoscopic features have not been described yet, and one could speculate that they are similar to those of Clark's nevi because the histopathologic architecture of Spark's nevus is similar to that of a Clark's nevus, resembling Spitz's nevi in the epithelioid morphology of melanocytes...
April 2018: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/29785325/screening-for-malignant-melanoma-a-critical-assessment-in-historical-perspective
#3
Wolfgang Weyers
Screening for melanoma has been advocated for many years because early detection and excision have been regarded as the most important measure to lower mortality from that neoplasm. In the past decade, concern has been raised by epidemiologists that screening might result in excision chiefly of "inconsequential cancer," i.e., melanomas that would never have progressed into life-threatening tumors, a phenomenon referred to by the misleading term "overdiagnosis." Without any firm evidence, that speculation has been embraced worldwide, and incipient melanomas have been trivialized...
April 2018: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/29782304/role-of-in-vivo-reflectance-confocal-microscopy-in-the-analysis-of-melanocytic-lesions
#4
Elena-Daniela Serban, Francesca Farnetani, Giovanni Pellacani, Maria Magdalena Constantin
Worldwide melanoma incidence and mortality are increasing (1). Despite the ongoing research, advanced melanoma is still incurable; therefore, the most appropriate solution seems to be early detection combined with complete surgical excision (2). Since the diagnostic protocol of suspicious lesions includes a complete excision with safety margins (2), the problem of unnecessary scarring is significant. The real challenge in this case is to have a properly formulated diagnosis before acquiring a biopsy. Currently available non-invasive techniques are coherence tomography, digital dermoscopy, and reflectance confocal microscopy...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29780659/confocal-microscopy-in-skin-cancer
#5
REVIEW
Verena Ahlgrimm-Siess, Martin Laimer, Harold S Rabinovitz, Margaret Oliviero, Rainer Hofmann-Wellenhof, Ashfaq A Marghoob, Alon Scope
Purpose of Review: Reflectance confocal microscopy (RCM) enables imaging of skin lesions at cellular level resolution at the bedside (in vivo) or in freshly excised tissue (ex vivo). This article provides an overview of strengths and limitations of non-invasive RCM in skin cancer diagnosis. Recent Findings: RCM features of common melanocytic and non-melanocytic skin neoplasms such as melanoma, actinic keratosis/squamous cell carcinoma, basal cell carcinoma, and nevi have been well defined and show good correlation with dermoscopic and histopathologic findings...
2018: Current Dermatology Reports
https://www.readbyqxmd.com/read/29775633/braf-v600e-mutations-in-nevi-and-melanocytic-tumors-of-uncertain-malignant-potential-meltumps
#6
Ruth Seitz-Alghrouz, Jose Villacorta Hidalgo, Claudia Kayser, Clemens Kreutz, Kristin Technau-Hafsi, Carlos Diaz, Andreas von Deimling, Jens Timmer, Martin Werner, Miroslav Malkovsky, Paul Fisch
No abstract text is available yet for this article.
May 15, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29774360/histologic-mimics-of-malignant-melanoma
#7
Caroline Bsirini, Bruce R Smoller
Although spongiotic (eczematous), psoriatic and cutaneous skin infections are among the most common dermatology consultations, melanocytic lesions - including the different types of nevi and melanomas - are among those that cause a great deal of concern and stress to patients and their clinicians. A diagnosis of benign melanocytic nevus carries a very good prognosis. However, a diagnosis of melanoma might imply more aggressive treatment, lifelong surveillance and a worse prognosis. Differentiating between these conditions is not always a straightforward process for clinicians and pathologists...
May 18, 2018: Singapore Medical Journal
https://www.readbyqxmd.com/read/29771688/plexiform-atypical-spitz-tumor-with-rosette-like-giant-cells-a-histologic-and-immunohistochemical-study-on-a-case-suggesting-ganglioneuroblastic-differentiation-review-of-the-literature-and-considerations-on-histogenesis
#8
Elena Castelli, Elisabetta Orlando, Giuseppe Pistone, Maria R Bongiorno
Spitz nevi, atypical Spitz tumors and Spitzoid melanoma, the three clinicopathologic forms that constitute the spectrum of the Spitz-type melanocytic lesions, share a histologic picture characterized by large spindle and/or epithelioid ganglion-like cells, with various admixtures of multinucleate bizarre cells. This remarkable cytology has always been interpreted as an unusual, as well as unexplained form of atypia. We report a case of atypical Spitz tumor with Homer Wright-like rosettes, a feature characteristic of ganglioneuroblastic proliferation...
May 16, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29741410/management-of-resistant-halo-nevi
#9
Sherif S Awad, Rasha Ta Abdel Aziz, Sahar S Mohammed
BACKGROUND: Halo nevus (HN) is a rare dermatologic disorder characterized by typical whitish rim surrounding an existing melanocytic nevus resembling halo. It is a cosmetic problem that may be linked to vitiligo, and it is advised to remove these nevi in order to avoid development of vitiligo. OBJECTIVES: The aim of the present study is to evaluate the cosmetic outcome after nevus removal and leukoderma dermabrasion with epithelial graft followed by narrow-band ultraviolet B (NB-UVB) phototherapy as management of resistant halo nevi and avoidance of development of vitiligo...
May 9, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29736211/therapeutic-effects-of-targeting-ras-erk-signaling-in-giant-congenital-melanocytic-nevi
#10
Qingxiong Yu, Min Wu, Lingling Sheng, Qingfeng Li, Feng Xie
Most giant congenital melanocytic nevi (GCMN) exhibit an activating mutation in NRAS. Constitutive activation of the RAS-ERK signaling pathway induces proliferation in nevus cells and plays a pivotal role in melanoma development. In this study, we studied the efficacy of RAS-ERK pathway targeted therapy in GCMN. We isolated nevus cells from GCMN (GNCs) and compared the morphology of GNCs with normal melanocytes and the A375 melanoma cell line. Proliferation curves of GNCs and A375 cells were determined using Cell Counting Kit-8 assays...
2018: American Journal of Translational Research
https://www.readbyqxmd.com/read/29707138/enhanced-intratumoral-expression-of-rnf2-is-a-favorable-prognostic-factor-for-patients-with-cutaneous-melanoma
#11
Łukasz Kuźbicki, Dariusz Lange, Agata Stanek-Widera, Agnieszka Glińska, Barbara W Chwirot
Recent studies involving melanoma cell lines suggest that enhanced expression of epigenetic regulator RNF2 supports proliferation and promotes metastasis. However, it is not clear to what extent those data apply to disease progression and prognosis for melanoma patients. Therefore the aim of the present study was to assess the prognostic power of RNF2 intratumoral expression by melanoma cells. RNF2 was detected immunohistochemically in standard formalin-fixed paraffin-embedded samples of 9 benign nevi, 60 melanomas and 24 nodal metastases...
April 3, 2018: Oncotarget
https://www.readbyqxmd.com/read/29703880/intradermal-naevi-of-external-auditory-canal-unusual-location-with-a-unique-presentation
#12
S L Yatiee, M D Mohd Khairi, M S Md Salzihan, H B Ikmal
The incidence of intradermal nevus in the external auditory canal is uncommon. We herein are describing a case of 60-year-old lady who presented with foreign body sensation in the right external ear canal (EAC) with mild discomfort and ear bleed during ear picking. Otoscopic examination revealed hyperpigmented mass on the floor of the outer two third of EAC. Complete excisional biopsy of the mass resulted in histopathology findings of intradermal nevus. Despite the fact that the disease is not alarming, the possibilities of benign melanocytic nevi transformation into malignant lesions such as melanoma need to be ruled out...
April 2018: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/29683819/primary-and-metastatic-melanoma-with-ntrk-fusions
#13
Cecilia Lezcano, Alexander N Shoushtari, Charlotte Ariyan, Travis J Hollmann, Klaus J Busam
A number of oncogenic driver mutations have been identified in melanocytic nevi and melanoma, but translocations also play a role in tumorigenesis and provide potential therapeutic targets for malignant lesions. Various translocations, such as those involving the anaplastic lymphoma kinase (ALK), neurotrophic tropomyosin receptor kinase 1 (NTRK1), and NTRK3 have been reported in spitzoid melanocytic neoplasms leading to kinase-fusion proteins that result in immunohistochemically detectable ALK or NTRK expression...
April 20, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29673774/clinical-features-and-prognosis-of-asian-patients-with-acral-lentiginous-melanoma-who-have-nodal-nevi-in-their-sentinel-lymph-node-biopsy-specimen
#14
Ho-Jin Kim, Jeong-Wan Seo, Mee-Sook Roh, Ji-Hyun Lee, Ki-Hoon Song
BACKGROUND: Nodal melanocytic nevi (NN) encountered during sentinel lymph node biopsy (SLB) for malignant melanoma are usually difficult to distinguish from metastatic melanoma. However, NN have not been studied well in acral lentiginous melanoma (ALM) in Asian populations. OBJECTIVE: To investigate the clinical characteristics and significance of NN in SLBs from ALM patients. METHODS: We retrospectively analyzed 84 patients with ALM who underwent SLB between June 2010 and July 2017...
April 16, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29672361/oncocytic-metaplasia-in-melanocytic-tumors
#15
Christine Ahn, Emily DeSantis, Timothy McCalmont
Oncocytic metaplasia represents a histopathologic feature that can be observed in normal tissue such as salivary and lacrimal glands but may also constitute a degenerative metaplastic process as a result of repeated oxidative damage during cellular aging. Although cutaneous oncocytic metaplasia has been considered rare, the finding was seen in over one-third of melanocytic nevi prospectively evaluated, in one study. This case series reports on a small series of oncocytic melanocytic tumors, with the aim of describing this phenomenon in varied contexts and also describing the use of a mitochondrial antigen immunostain, which has not been previously reported...
April 17, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29665123/pilot-study-on-the-correlation-between-dermoscopic-patterns-and-fluorescence-in-situ-hybridization-findings-using-whole-slide-digital-imaging-for-acral-volar-melanocytic-lesions
#16
Dai Ogata, Eiichi Arai, Yoshiya Goto, Tetsuya Tsuchida
Dermoscopic evaluation of acral volar skin is helpful in differentiating malignant melanomas (MM) from benign melanocytic nevi. However, histological diagnosis remains difficult because sufficient evidence of histopathological changes to establish a diagnosis of MM are not easily obtained. The aim of the present study was to evaluate the effective use of fluorescence in situ hybridization (FISH) in the diagnosis of acral volar melanocytic lesions, and to determine whether acral volar melanocytic lesions show characteristic molecular biological features of malignant melanoma via FISH...
April 17, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/29664513/vitiligo-type-cutaneous-manifestation-of-chronic-graft-versus-host-disease-case-report
#17
Karla Gálvez, Paula Muñoz, Valentina Vera, Claudio Arce
INTRODUCTION: Graft-versus-host disease (GVHD) is caused by a pathologic and destructive response of the organism as a result of the interaction between donor immunocompetent T lymphocytes and the recipient tisular antigens. It's considered the most serious complication of hematopoietic stem cell transplantation, most frequently described after bone marrow transplantation (BMT). The skin is usually the first and most commonly affected organ, in both acute and chronic, with a variable clinical spectrum of presentation...
February 2018: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/29653212/improving-classification-of-melanocytic-nevi-braf-v600e-expression-associated-with-distinct-histomorphologic-features
#18
Maija Kiuru, Danielle M Tartar, Lihong Qi, Danyang Chen, Lan Yu, Thomas Konia, John D McPherson, William J Murphy, Maxwell A Fung
BACKGROUND: A subset of melanomas carrying a BRAF V600E mutation, the most common targetable mutation in melanoma, arises in association with a melanocytic nevus also harboring a BRAF V600E mutation. The detailed histomorphologic characteristics of BRAF V600E-positive nevi are not systematically documented. OBJECTIVE: To identify histomorphologic features correlating with BRAF V600E status in nevi. METHODS: We retrospectively identified melanocytic nevi from our laboratory reporting system...
April 10, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29624714/two-cases-of-discrete-adenoid-pseudogland-formation-within-benign-intradermal-melanocytic-nevi
#19
Jonathan C Banta, Justin P Bandino
We report two cases of benign intradermal melanocytic nevi with discrete glandular elements and mucin deposition engendering a diagnostic dilemma. The preliminary differential included entrapment of adnexal structures, collision with an adnexal neoplasm such as adenoid cystic carcinoma, or metastatic adenocarcinoma. A colloidal iron special stain confirmed the deposition of mucin, however a pankeratin AE1/AE3 immunohistochemical cocktail was surprisingly negative. Closer cytological examination of the discrete "glands" combined with nearby pseudoangiomatous (almost Kaposiform) change hinted at melanocytic origin, and was confirmed with a positive MART-1 immunohistochemical stain...
April 6, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29614272/sun-protection-behaviour-pubertal-development-and-menarche-factors-influencing-the-melanocytic-nevi-development-the-results-of-a-observational-study-on-1512-children
#20
Vincenzo De Giorgi, Alessia Gori, Antonella Greco, Imma Savarese, Barbara Alfaioli, Marta Grazzini, Susanna Rossari, Federica Papi, Federica Scarfì, Agata Janowska, Antonietta D'Errico, Lorenzo Salvati, Piero Covarelli, Sara Gandini
Observational studies consistently show that melanocytic nevus prevalence increases with age and that phenotypic traits are significantly associated with nevus count in children. An observational study of 1512 children and adolescents from 2010 to 2013 was conducted. Study dermatologists counted the full body, arm, and facial nevi of each participant. Children and their parents were asked to complete a survey to gather data on personal characteristics, pubertal development and early-life sun exposure. The main aim of the study was to establish pediatric nevus prevalence and its relationship to age, phenotype, sex, menarche, early-life sun exposure, and sun-protection behaviors...
March 31, 2018: Journal of Investigative Dermatology
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