Yannik Kalbas, Yohei Kumabe, Felix Karl Ludwig Klingebiel, Sascha Halvachizadeh, Michel Paul Johan Teuben, Miriam Weisskopf, Nikola Cesarovic, Andreas J Hülsmeier, Sonja Märsmann, Christian Hierholzer, Frank Hildebrand, Thorsten Hornemann, Roman Pfeifer, Paolo Cinelli, Hans-Christoph Pape
INTRODUCTION: Along with recent advances in analytical technologies, TCA-cycle intermediates are increasingly identified as promising makers for cellular ischemia and mitochondrial dysfunction during hemorrhagic shock (HS). For traumatized patients, the knowledge of the role of lipid oxidation substrates is sparse. In this study, we aimed to analyze the dynamics of systemic acylcarnitine (AcCa) release in a standardized polytrauma model with HS. METHODS: 52 male pigs (50 ± 5 kg) were randomized into two groups: Group IF (isolated fracture) was subject to a standardized femur shaft fracture...
March 29, 2024: Journal of Trauma and Acute Care Surgery