Anna Barile, Claudio Graziani, Lorenzo Antonelli, Alessia Parroni, Annarita Fiorillo, Martino Luigi di Salvo, Andrea Ilari, Alessandra Giorgi, Serena Rosignoli, Alessandro Paiardini, Roberto Contestabile, Angela Tramonti
Adequate levels of pyridoxal 5'-phosphate (PLP), the catalytically active form of vitamin B6 , and its proper distribution in the body are essential for human health. The PLP recycling pathway plays a crucial role in these processes and its defects cause severe neurological diseases. The enzyme pyridox(am)ine 5'-phosphate oxidase (PNPO), whose catalytic action yields PLP, is one of the key players in this pathway. Mutations in the gene encoding PNPO are responsible for a severe form of neonatal epilepsy. Recently, PNPO has also been described as a potential target for chemotherapeutic agents...
February 2024: Protein Science