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vitamine A Neonates

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https://www.readbyqxmd.com/read/29225576/vitamin-d-enhances-efficacy-of-oral-nifedipine-in-treating-preeclampsia-with-severe-features-a-double-blinded-placebo-controlled-and-randomized-clinical-trial
#1
Dan-Dan Shi, Yong Wang, Jun-Jun Guo, Ling Zhou, Na Wang
Vitamin D (VD) has exhibited immunomodulatory role in the pathogenesis of preeclampsia. We hypothesize VD potentiate nifedipine treatment for preeclampsia by shortened the time to control blood pressure and prolong time before subsequent hypertensive crisis. We conduct a randomized trial of 683 primigravid women with preeclampsia, who were assigned to different treatment groups, either nifedipine+placebo or nifedipine+VD orally, by random after screening. Primary endpoints include time to control hypertension and time before another hypertensive crisis...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29196501/vitamin-d-binding-protein-rs7041-genotype-alters-vitamin-d-metabolism-in-pregnant-women
#2
Ariel B Ganz, Heyjun Park, Olga V Malysheva, Marie A Caudill
Research has identified reduced circulating 25-hydroxyvitamin D [25(OH)D] in individuals with the rs7041 (c.1296T>G) T allele in the vitamin D binding protein gene (GC); however, the effects of the T allele on vitamin D biomarkers during pregnancy and lactation are unknown. Thus, we examined the metabolic effects of GC rs7041 on vitamin D biomarkers among third-trimester pregnant (n = 26), lactating (n = 28), and nonpregnant/nonlactating (n = 21) women consuming a single amount of vitamin D (511 IU/d) and related nutrients for 10-12 wk...
December 1, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29187358/vitamin-d-supplementation-during-pregnancy-state-of-the-evidence-from-a-systematic-review-of-randomised-trials
#3
Daniel E Roth, Michael Leung, Elnathan Mesfin, Huma Qamar, Jessica Watterworth, Eszter Papp
Objectives To estimate the effects of vitamin D supplementation during pregnancy on 11 maternal and 27 neonatal/infant outcomes; to determine frequencies at which trial outcome data were missing, unreported, or inconsistently reported; and to project the potential contributions of registered ongoing or planned trials.Design Systematic review and meta-analysis of randomised controlled trials; systematic review of registered but unpublished trials.Data sources Medline, Embase, PubMed, Cochrane Database of Systematic Reviews, and Cochrane Central Register of Controlled Trials from inception to September 2017; manual searches of reference lists of systematic reviews identified in the electronic search; and online trial registries for unpublished, ongoing, or planned trials...
November 29, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29186303/maternal-and-neonatal-vitamin-d-status-are-not-associated-with-risk-of-childhood-type-1-diabetes-a-scandinavian-case-cohort-study
#4
Steffen U Thorsen, Karl Mårild, Sjurdur F Olsen, Klaus K Holst, German Tapia, Charlotta Granström, Thorhallur I Halldorsson, Arieh S Cohen, Margaretha Haugen, Marika Lundqvist, Torild Skrivarhaug, Pål R Njølstad, Geir Joner, Per Magnus, Ketil Størdal, Jannet Svensson, Lars C Stene
Studies on vitamin D status during pregnancy and risk of type 1 diabetes (T1D) lack consistency, and are limited by small sample sizes or single measures of 25-hydroxyvitamin D (25(OH)D). We investigated whether average maternal 25(OH)D plasma concentrations during pregnancy are associated with risk of childhood T1D. In a case-cohort design, we identified 459 children with T1D and a random sample (n = 1,561) from the Danish National Birth Cohort (n = 97,127) and Norwegian Mother and Child Cohort Study (n = 113,053)...
November 23, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29179976/vitamin-c-prevents-hypothyroidism-associated-neuronal-damage-in-the-hippocampus-of-neonatal-and-juvenile-rats-a-stereological-study
#5
Elnaz Khordad, Fatemeh Alipour, Farimah Beheshti, Mahmoud Hosseini, Ali Akbar Rajabzadeh, Farimah Asiaei, Masoumeh Seghatoleslam
Hypothyroidism causes an imbalance in antioxidant and pro-oxidants criteria in the brain and enhances the concentration of reactive oxygen species (ROS), and neuronal damage has been observed following an excessive ROS. The main purpose of this study was to examine the preventive effect of vitamin C on hypothyroidism associated neuronal damage in the hippocampus of neonatal and juvenile rats. Pregnant rats after delivery of their pups were randomly divided into four groups and treated with (1) normal drinking water as a control group, (2) Propylthiouracil (PTU) 0...
November 24, 2017: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/29178513/relationship-between-neonatal-vitamin-d-at-birth-and-risk-of-autism-spectrum-disorders-the-nbsib-study
#6
Dong-Mei Wu, Xin Wen, Xin-Rui Han, Shan Wang, Yong-Jian Wang, Min Shen, Shao-Hua Fan, Juan Zhuang, Meng-Qiu Li, Bin Hu, Chun-Hui Sun, Ya-Xing Bao, Jing Yan, Jun Lu, Yuan-Lin Zheng
Previous studies suggested that lower vitamin D might be a risk factor for autism spectrum disorders (ASDs). The aim of this study was to estimate the prevalence of ASDs in 3-year-old Chinese children and to examine the association between neonatal vitamin D status and risk of ASDs. We conducted a study of live births who had taken part in expanded newborn screening (NBS), with outpatient follow-up when the children 3-year old. The children were confirmed for ASDs in outpatient by the Autism Diagnostic Interview-Revised and Diagnostic and Statistical Manual of Mental Disorders (DSM)-5 criteria...
November 27, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29172662/-maternal-and-neonatal-vitamin-b12-deficiency-detected-by-expanded-newborn-screening
#7
Ferenc Papp, Gábor Rácz, István Lénárt, Jenő Kóbor, Csaba Bereczki, Eszter Karg, Ákos Baráth
INTRODUCTION: Infant vitamin B12 deficiency can manifest as a severe neurodegenerative disorder and is usually caused by maternal deficiency due to vegetarian diet or pernicious anaemia. Its early recognition and treatment can prevent potentially serious and irreversible neurologic damage. Biochemically, vitamin B12 deficiency leads to an accumulation of methylmalonic acid, homocysteine, and propionylcarnitine. Expanded newborn screening using tandem mass spectrometry may identify neonatal and maternal vitamin B12 deficiency by measurement of propionylcarnitine and other metabolites in the dried blood spot sample of newborns...
December 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/29169993/impact-of-vitamin-d-on-pregnancy-related-disorders-and-on-offspring-outcome
#8
REVIEW
Karoline von Websky, Ahmed Abdallah Hasan, Christoph Reichetzeder, Oleg Tsuprykov, Berthold Hocher
Observational studies from all over the world continue to find high prevalence rates of vitamin D insufficiency and deficiency in many populations, including pregnant women. Beyond its classical function as a regulator of calcium and phosphate metabolism, vitamin D elicits numerous effects in the human body. Current evidence highlights a vital role of vitamin D in mammalian gestation. During pregnancy, adaptations in maternal vitamin D metabolism lead to a physiologic increase of vitamin D levels, mainly because of an increased renal production, although other potential sources like the placenta are being discussed...
November 21, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29166972/long-term-sex-differential-effects-of-neonatal-vitamin-a-supplementation-on-in-vitro-cytokine-responses
#9
Kristoffer J Jensen, Mia J Søndergaard, Andreas Andersen, Cesario Martins, Christian Erikstrup, Peter Aaby, Katie L Flanagan, Christine Stabell Benn
High-dose vitamin A supplementation (VAS) may affect mortality to infectious diseases in a sex-differential manner. Here, we analysed the long-term immunological effects of neonatal vitamin A supplementation (NVAS) in 247 children, who had been randomly allocated to 50 000 or 25 000 IU vitamin A (15mg and 7·5mg retinol equivalents, respectively) or placebo at birth. At 4-6 months of age, we assessed bacille Calmette-Guérin (BCG) scarification, and we analysed in vitro responses of TNF-α, IL-5, IL-10, IL-13 and IFN-γ in whole blood stimulations to phytohaemagglutinin (PHA), purified protein derivative (PPD), tetanus toxoid and lipopolysaccharide...
November 23, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/29164128/peptides-released-from-foremilk-and-hindmilk-proteins-by-breast-milk-proteases-are-highly-similar
#10
Søren D Nielsen, Robert L Beverly, David C Dallas
Human milk contains active proteases that initiate hydrolysis of milk proteins within the mammary gland. Milk expressed at the beginning of feeding is known as foremilk and that at the end of feeding is known as hindmilk. As hindmilk contains higher fat, vitamins A and E, and higher calories than foremilk, feeding only hindmilk initially and reserving foremilk for later are practiced in some neonatal intensive care units. This study investigated the difference in peptide profiles, predicted milk protease activities, and bioactive peptides between foremilk and hindmilk...
2017: Frontiers in Nutrition
https://www.readbyqxmd.com/read/29153160/a-100-year-review-calf-nutrition-and-management
#11
A F Kertz, T M Hill, J D Quigley, A J Heinrichs, J G Linn, J K Drackley
The first calf paper, published in the May 1919 issue of the Journal of Dairy Science (JDS), described factors affecting birth body weight of different breeds of calves. Other studies were done on nonmilk ingredients, growth charts were developed, and early weaning was followed to conserve milk fed to calves. Calf papers did not report use of statistics to control or record variation or to determine whether treatment means were different. Many experiments were more observational than comparative. Typically fewer than 5 calves, and sometimes 1 or 2 calves, were used per treatment...
December 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29151248/adiponectin-and-vitamin-d-binding-protein-are-independently-associated-at-birth-in-both-mothers-and-neonates
#12
Spyridon N Karras, Stergios Α Polyzos, Danforth A Newton, Carol L Wagner, Bruce W Hollis, Jody van den Ouweland, Erdinc Dursun, Duygu Gezen-Ak, Kalliopi Kotsa, Cedric Annweiler, Declan P Naughton
CONTEXT: Adult body fat is associated with birth anthropometry, suggesting a role for metabolic regulators including vitamin D and the adipokines-adiponectin and irisin-which have been reported to interact but, as yet, data remain controversial. OBJECTIVE: To study (i) the relationship between vitamin D, its binding protein (VDBP) and the adipokines, adiponectin, and irisin in mothers and neonates at birth and (ii) their effects on neonate anthropometric outcomes...
November 18, 2017: Endocrine
https://www.readbyqxmd.com/read/29146216/-nisch-syndrome-a-rare-cause-of-neonatal-cholestasis-a-case-report
#13
S Szepetowski, C Lacoste, S Mallet, B Roquelaure, C Badens, A Fabre
NISCH syndrome is a rare autosomal recessive disease. It is characterized by scalp hypotrichosis, scarring alopecia, ichthyosis, and neonatal sclerosing cholangitis. It is caused by mutations in the CLDN1 gene encoding the claudin-1 protein, which is located at tight junctions. Fifteen cases have been reported to date and three different mutations have been identified. We report on the case of a 2-year-old boy from a consanguineous Moroccan family, presenting with NISCH syndrome and carrying the so-called Moroccan homozygous mutation (c...
November 13, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/29143623/the-impact-of-eliminating-within-country-inequality-in-health-coverage-on-maternal-and-child-mortality-a-lives-saved-tool-analysis
#14
Adrienne Clermont
BACKGROUND: Inequality in healthcare across population groups in low-income countries is a growing topic of interest in global health. The Lives Saved Tool (LiST), which uses health intervention coverage to model maternal, neonatal, and child health outcomes such as mortality rates, can be used to analyze the impact of within-country inequality. METHODS: Data from nationally representative household surveys (98 surveys conducted between 1998 and 2014), disaggregated by wealth quintile, were used to create a LiST analysis that models the impact of scaling up health intervention coverage for the entire country from the national average to the rate of the top wealth quintile (richest 20% of the population)...
November 7, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29137132/maternal-vitamin-d-status-and-the-relationship-with-neonatal-anthropometric-and-childhood-neurodevelopmental-outcomes-results-from-the-seychelles-child-development-nutrition-study
#15
Eamon Laird, Sally W Thurston, Edwin van Wijngaarden, Conrad F Shamlaye, Gary J Myers, Philip W Davidson, Gene E Watson, Emeir M McSorley, Maria S Mulhern, Alison J Yeates, Mary Ward, Helene McNulty, J J Strain
Vitamin D has an important role in early life; however, the optimal vitamin D status during pregnancy is currently unclear. There have been recent calls for pregnant women to maintain circulating 25-hydroxyvitamin D (25(OH)D) concentrations >100 nmol/L for health, yet little is known about the long-term potential benefits or safety of achieving such high maternal 25(OH)D concentrations for infant or child health outcomes. We examined maternal vitamin D status and its associations with infant anthropometric and later childhood neurocognitive outcomes in a mother-child cohort in a sun-rich country near the equator (4...
November 11, 2017: Nutrients
https://www.readbyqxmd.com/read/29137047/massive-neonatal-intracranial-hemorrhage-caused-by-bromadiolone-a-case-report
#16
Mingsheng Ma, Mengqi Zhang, Xiaoyan Tang, Zhenghong Li
RATIONALE: Bromadiolone, often called a super-warfarin, is a potent rodenticide with long half-life. Skin and mucosal bleeding is the most common clinical manifestations of its intoxication. Bromadiolone intoxications in adults and children have been reported, but this phenomenon is rarely seen in fetuses. This paper presents a case of neonate with massive intracranial hemorrhage mediated by bromadiolone intoxication, highlighting that the bromadiolone is potentially lethal to the fetus...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29132733/enhanced-nutrient-supply-to-very-low-birth-weight-infants-is-associated-with-higher-blood-amino-acid-concentrations-and-improved-growth
#17
Kenneth Strømmen, Alexander Haag, Sissel J Moltu, Marit B Veierød, Elin W Blakstad, Britt Nakstad, Astrid N Almaas, Kristin Brække, Arild E Rønnestad, Hannelore Daniel, Christian A Drevon, Per O Iversen
BACKGROUND & AIMS: Customized nutrient supply is vital to ensure optimal growth among very low birth weight infants (birth weight < 1500 g). The supply of amino acids is especially important due to their impact on protein synthesis and growth. The objectives of this study were to evaluate the impact of enhanced nutrition on growth, blood concentrations of amino acids, and explore possible associations between amino acid concentrations and common neonatal morbidities. We hypothesized higher amino acids levels and growth velocity among infants on enhanced nutrient supply...
April 2017: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29130703/nutritional-practices-in-very-low-birth-weight-infants-a-national-survey
#18
Miguel Sáenz de Pipaón, Ricardo Closa, María Gormaz, Marcos Linés, Eduardo Narbona, Gerardo Rodríguez-Martínez, José Uberos, Carlos Zozaya, María L Couce
BACKGROUND: Significant efforts have been made to improve the nutritional support of very preterm infants. Large surveys may help to know the nutritional practices for preterm infants in neonatal units and identify if they are in line with the current guidelines. METHODS: A multicentre nationwide web-based survey on clinical feeding practices in very low birth weight (VLBW) infants was conducted in tertiary neonatal hospitals that admit infants with a birth weight < 1,500 g and/or a gestational age of < 32 weeks...
October 24, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29128634/vitamin-d-receptor-vdr-polymorphisms-are-associated-to-spontaneous-preterm-birth-and-maternal-aspects
#19
N R Javorski, C A D Lima, L V C Silva, S Crovella, J de Azêvedo Silva
Preterm birth (PTB) is featured by less than 37weeks of gestational age or fewer than 259days since the first day from the last menstrual period. Complications of PTB are the major cause of neonatal deaths, several factors are linked to PTB increased risk including immunological and genetics. Vitamin D plays an important role in immune response modulation and its action occurs through the vitamin D receptor (VDR), which recently has been described as overexpressed in human placenta during the pregnancy. Herein we assessed two single nucleotide polymorphisms (SNPs) FokI (rs2228570 A>G) and Cdx-2 (rs11568820 T>C), within VDR, using TaqMan fluorogenic probes, and differential susceptibility to SPTB...
November 8, 2017: Gene
https://www.readbyqxmd.com/read/29122831/fifteen-minute-consultation-liver-disease-in-children
#20
Jake P Mann, Kathy Gallagher, Emer Fitzpatrick, Anil Dhawan
Liver disease in children can present in many ways from the frequently encountered prolonged neonatal jaundice to the comparatively rare acute liver failure. In this article, we will discuss 'red flags' of liver disease, the initial investigations required and when to refer to a specialist liver centre. Across all presentations, the degree of elevation of alanine aminotransferase or aspartate aminotransferase provides only little diagnostic information. Measurement of clotting is vital, and coagulopathy should be followed by a trial of intravenous vitamin K before being repeated...
November 9, 2017: Archives of Disease in Childhood. Education and Practice Edition
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