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vitamine A Neonates

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https://www.readbyqxmd.com/read/29662712/do-syrian-refugees-have-increased-risk-for-worser-pregnancy-outcomes-results-of-a-tertiary-center-in-%C3%A4-stanbul
#1
Emre Sinan Güngör, Olcay Seval, Gülşah İlhan, Fatma Ferda Verit
Objective: To compare obstetric and perinatal outcomes of Syrian refugee pregnants and Turkish counterparts who gave birth at a tertiary center in İstanbul. Materials and Methods: A retrospective study including the birth records of 704 Syrian refugees and 744 Turkish pregnant women between January 2016 and May 2017 were analyzed. Demographic data, obstetric and neonatal outcomes were compared. The primary aims of this study were to evaluate the pregnancy outcomes and cesarean rates between the groups...
March 2018: Turkish Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29661840/therapeutic-potential-of-a-novel-necrosis-inhibitor-7-amino-indole-in-myocardial-ischemia-reperfusion-injury
#2
In-Chang Hwang, Ju-Young Kim, Ji-Hyun Kim, Joo-Eun Lee, Ji-Yun Seo, Jae-Won Lee, Jonghanne Park, Han-Mo Yang, Soon-Ha Kim, Hyun-Jai Cho, Hyo-Soo Kim
Opening of mitochondrial permeability transition pore and Ca2+ overload are main contributors to myocardial ischemia-reperfusion injury, which paradoxically causes a wide variety of myocardial damage. We investigated the protective role of a novel necrosis inhibitor (NecroX-7; NecX) against myocardial ischemia-reperfusion injury using in vitro and in vivo models. H9C2 rat cardiomyoblasts and neonatal cardiomyocytes were exposed to hypoxia-reoxygenation stress after pre-treatment with NecX, vitamin C, a combination of vitamin C and E, N-acetylcysteine, an apoptosis inhibitor (Z-VAD-fmk), or cyclosporine A...
April 16, 2018: Hypertension
https://www.readbyqxmd.com/read/29657898/slow-elevation-in-protein-c-activity-without-a-proc-mutation-in-a-neonate-with-intracranial-hemorrhage
#3
Erika Uehara, Hiro Nakao, Yusuke Tsumura, Hisaya Nakadate, Shoichiro Amari, Hideshi Fujinaga, Yoshiyuki Tsutsumi, Dongchon Kang, Shouichi Ohga, Akira Ishiguro
Severe protein C (PC) deficiency leads to purpura fulminans and stroke in newborns. However, the clinical impact of plasma PC activity on the development of neonatal cerebral disease remains elusive. We report a case of hemorrhagic stroke associated with neonatal asphyxia and severe PC deficiency. Plasma PC and protein S activity 7 days after birth was 12% and 43%, respectively. No PROC mutation was found. PC levels did not exceed 20% until 2 months of age, even in the absence of consumption coagulopathy or vitamin K deficiency...
April 2018: American Journal of Perinatology Reports
https://www.readbyqxmd.com/read/29610166/b-6-and-bleeding-a-case-report-of-a-novel-vitamin-toxicity
#4
Alexandra J Borst, Dmitry Tchapyjnikov
Pyridox(am)ine-5-phosphate oxidase deficiency is an inborn error of vitamin B6 metabolism that is characterized by neonatal seizures, requiring lifelong therapy with pyridoxal-5-phosphate. We present the first case of a patient with pyridox(am)ine-5-phosphate oxidase deficiency and mild hemophilia A, whose bleeding symptoms were exacerbated by the vitamin B6 therapy essential for his epileptic disorder. This report expands the spectrum of known vitamin B6 toxicity and demonstrates a need for vigilance in monitoring for bleeding symptoms in patients requiring pyridoxine or pyridoxal-5-phosphate supplementation...
April 2018: Pediatrics
https://www.readbyqxmd.com/read/29588985/ketogenic-parenteral-nutrition-in-17-pediatric-patients-with-epilepsy
#5
Anastasia Dressler, Nadja Haiden, Petra Trimmel-Schwahofer, Franz Benninger, Sharon Samueli, Gudrun Gröppel, Sina Spatzierer, Angelika Mühlebner, Klaus Abraham, Martha Feucht
Objective: Ketogenic parenteral nutrition (kPN) is indicated when enteral intake is temporarily limited or impossible, but evidence-based prescriptions are lacking. Objective was to evaluate the efficacy and safety of kPN in children with epileptic encephalopathies using a new computer-based algorithm for accurate component calculating. Methods: Children with epilepsy receiving kPN were included. A computer-based algorithm was established on the basis of guidelines of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN): fat intake not exceeding 4 g/kg/day, age-adequate supply of protein, electrolytes, vitamins, and trace elements, but reduced carbohydrates...
March 2018: Epilepsia open
https://www.readbyqxmd.com/read/29588821/serum-level-of-vitamin-d-in-preterm-infants-and-its-association-with-premature-related-respiratory-complications-a-case-control-study
#6
Hasan Boskabadi, Gholamali Mamoori, Seyedeh Fatemeh Khatami, Raheleh Faramarzi
Background and aim: Prematurity and related problems, especially respiratory distress, are one of the main challenges for neonatal medicine. The aim of this study was to compare vitamin D levels in preterm infants with, and those without respiratory distress. Methods: This case-control study was conducted in Ghaem and Emam Reza Hospitals in Mashhad (Iran) from 2015 to 2016. In this study, we examined 160 preterm infants weighing less than 2000 grams and born at less than 34 weeks' gestation...
January 2018: Electronic Physician
https://www.readbyqxmd.com/read/29570909/effect-of-prolonged-hospitalization-for-threatened-preterm-labor-on-maternal-and-fetal-vitamin-d-levels
#7
Naoto Yonetani, Takashi Kaji, Atsuko Hichijo, Soichiro Nakayama, Kazuhisa Maeda, Minoru Irahara
AIM: We aimed to evaluate the effect of prolonged hospitalization for threatened preterm labor (TPL) on maternal and fetal vitamin D status. METHODS: This was a retrospective cohort study, spanning 4 years, including 18 women with TPL and 36 women with normal pregnancy who received prenatal care for a singleton pregnancy at our center. TPL cases were women who were admitted to our hospital after the second trimester test for at least 28 days, during which time the third trimester test was also performed...
March 23, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29563389/vitamin-b-3-nicotinamide-a-promising-candidate-for-treating-preeclampsia-and-improving-fetal-growth
#8
Nobuyuki Takahashi, Feng Li, Tomofumi Fushima, Gen Oyanagi, Emiko Sato, Yuji Oe, Akiyo Sekimoto, Daisuke Saigusa, Hiroshi Sato, Sadayoshi Ito
Up to 8% of pregnant women suffer from preeclampsia (PE), a deadly disease characterized by high blood pressure (BP), blood vessel damage, called endotheliosis (vascular endothelial swelling with narrowing of capillary lumen), and high levels of protein in the urine. PE is often associated with premature delivery, which is a risk factor of cardiovascular and metabolic diseases among the offspring. Accordingly, establishing drug treatments of PE is in immediate needs. Currently, many of anti-hypertensive drugs cause malformation of the fetuses and are contraindicated for pregnant women...
March 2018: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29562766/parathyroid-hormone-reference-values-and-association-with-other-bone-metabolism-markers-in-very-low-birth-weight-infants-pilot-study
#9
Tomas Matejek, Martina Navratilova, Lenka Zaloudkova, Jana Malakova, Jan Maly, Sylva Skalova, Vladimir Palicka
PURPOSE: The aim of this pilot study was to estimate physiological parathyroid hormone (PTH) levels and their relationship with bone metabolism parameters in otherwise healthy preterm newborns with birth weight 1000-1500 g. METHODS: PTH, 25(OH)D, S-Ca, S-P, and ALP were analysed from blood samples obtained from 20 preterm infants once a week up to the 36th gestational week. RESULTS: Of the total 134 examined serum samples for PTH levels, the estimated range was 1...
March 21, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29544584/pattern-of-vitamin-d-among-pakistani-pregnant-women
#10
Jamal Abdul Nasir, Muhammad Imran, Syed Arif Ahmed Zaidi
Vitamin D deficiency is an emerging health concern around the world, highly prevalent in south Asian population, despite abundant sunlight. In Pakistan, all age groups are vulnerable to Vitamin D deficiency including pregnant women. This systematic review aimed to determine the pattern of Vitamin D deficiency among Pakistani pregnant women as well as exploring the causes and possible interventions that have had a substantial effect on improving the vitamin D level. Three databases (PubMed, Pub Get and Google Scholar), for the present review up to 2016, were used for the identification of published peer reviewed original relevant studies regarding Vitamin D deficiency among Pakistani pregnant women with the keywords Vitamin D or 25-hydroxyvitamin D or 25(OH)D in combination with pregnant women...
March 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29543302/neonatal-hypocalcemia-and-its-relation-to-vitamin-d-and-calcium-supplementation
#11
Asmaa Y Elsary, Alkassem A Elgameel, Wael S Mohammed, Osman M Zaki, Shaimaa A Taha
To assess the prevalence of hypocalcemia in outpatient clinic neonates and its relation to vitamin D and calcium supplementation.  Methods: This cross-sectional analytical study was conducted at the University Teaching Hospital from May to October 2016. Data were collected from 100 neonates by interviewing mothers using a structured questionnaire; which included socio-demographic information, maternal and neonatal history; in addition to investigations of serum calcium total and ionized and serum vitamin D level...
March 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/29540231/vitamin-k-deficiency-a-case-report-and-review-of-current-guidelines
#12
Maria Rosaria Marchili, Elisa Santoro, Alessandra Marchesi, Simona Bianchi, Lelia Rotondi Aufiero, Alberto Villani
BACKGROUND: Vitamin K, a fat soluble vitamin, is a necessary cofactor for the activation of coagulation factors II, VII, IX, X, and protein C and S. In neonatal period, vitamin K deficiency may lead to Vitamin K Deficiency Bleeding (VKDB). CASE PRESENTATION: We present the case of a 2 months and 20 days Caucasian male, presented for bleeding from the injections sites of vaccines. At birth oral vitamin K prophylaxis was administered. Neonatal period was normal...
March 14, 2018: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/29530503/vitamin-d-deficiency-and-vitamin-d-receptor-variants-in-mothers-and-their-neonates-are-risk-factors-for-neonatal-sepsis
#13
Safaa I Tayel, Shimaa E Soliman, Hanan M Elsayed
BACKGROUND AND AIM: increasing prevalence of neonatal sepsis in recent years catch attention to early prevention and management. Vitamin D receptor (VDR) polymorphism can modulate VDR expression level that greatly influences immunity and susceptibility to microbial infections. We aimed to investigate the association of VDR polymorphism at FokI, rs2228570 T/C, and TaqI, rs731236 C/T gene with serum 25-hydroxyvitamin D level and risk of neonatal sepsis. METHODS: This work carried on 160 subjects classified into 80 cases (40 mothers and their 40 septic neonates) and 80 healthy controls (40 volunteer mothers and their 40 healthy neonates)...
March 9, 2018: Steroids
https://www.readbyqxmd.com/read/29523876/association-between-maternal-mid-gestation-vitamin-d-status-and-neonatal-abdominal-adiposity
#14
Mya Thway Tint, Mary F Chong, Izzuddin M Aris, Keith M Godfrey, Phaik Ling Quah, Jeevesh Kapur, Seang Mei Saw, Peter D Gluckman, Victor S Rajadurai, Fabian Yap, Michael S Kramer, Yap-Seng Chong, Christiani Jeyakumar Henry, Marielle V Fortier, Yung Seng Lee
OBJECTIVES: Lower vitamin D status has been associated with adiposity in children through adults. However, the evidence of the impact of maternal vitamin-D status during pregnancy on offspring's adiposity is mixed. The objective of this study was to examine the associations between maternal vitamin-D [25(OH)D] status at mid-gestation and neonatal abdominal adipose tissue (AAT) compartments, particularly the deep subcutaneous adipose tissue linked with metabolic risk. METHODS: Participants (N = 292) were Asian mother-neonate pairs from the mother-offspring cohort, Growing Up in Singapore Towards healthy Outcomes...
March 9, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29519632/total-antioxidant-status-in-fresh-and-stored-human-milk-from-mothers-of-term-and-preterm-neonates
#15
Luminiţa Păduraru, Daniela Cristina Dimitriu, Andreea Luciana Avasiloaiei, Mihaela Moscalu, Gabriela Ildiko Zonda, Maria Stamatin
BACKGROUND: Antioxidant defense of the body is assured by both endogenous and exogenous factors comprising several enzymes, vitamins, protein components and derivates and oligoelements. Breast milk has been proven to have important and essential antioxidant composition to prevent and protect against diseases in infancy. The objective of this study was to determine the total antioxidant status (TAS) of human milk and to evaluate the differences between premature milk and term milk at different moments of lactation (colostrum, transitional milk and mature milk)...
February 8, 2018: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/29518647/vitamin-d-deficiency-and-respiratory-morbidity-among-african-american-very-low-birth-weight-infants
#16
S Nadya J Kazzi, Sreenivas Karnati, Subhash Puthuraya, Ronald Thomas
BACKGROUND: Very low birth weight infants (VLBWI) have unexplained variation in respiratory morbidity, including respiratory distress syndrome (RDS) and bronchopulmonary dysplasia (BPD). We examined a potential association to serum 25-hydroxyvitamin D (s-25OHD) on day one. STUDY DESIGN: Prospective, observational study on 89 VLBWI (≤1250 g). S-25OHD (day one and 21) and respiratory severity score (RSS) (day one) were examined. Other respiratory morbidities including BPD were compared between infants with s-25OHD ≤ 10 ng/ml (deficient) versus >10 ng/ml (adequate)...
April 2018: Early Human Development
https://www.readbyqxmd.com/read/29514147/update-on-vitamin-e-and-its-potential-role-in-preventing-or-treating-bronchopulmonary-dysplasia
#17
Cosby A Stone, Cindy T McEvoy, Judy L Aschner, Ashudee Kirk, Christian Rosas-Salazar, Joan M Cook-Mills, Paul E Moore, William F Walsh, Tina V Hartert
Vitamin E is obtained only through the diet and has a number of important biological activities, including functioning as an antioxidant. Evidence that free radicals may contribute to pathological processes such as bronchopulmonary dysplasia (BPD), a disease of prematurity associated with increased lung injury, inflammation and oxidative stress, led to trials of the antioxidant vitamin E (α-tocopherol) to prevent BPD with variable results. These trials were all conducted at supraphysiologic doses and 2 of these trials utilized a formulation containing a potentially harmful excipient...
March 7, 2018: Neonatology
https://www.readbyqxmd.com/read/29496275/vitamin-e-status-and-associations-in-maternal-infant-dyads-in-the-midwestern-united-states
#18
Corrine Hanson, Elizabeth Lyden, Jeremy Furtado, Matthew Van Ormer, Marina Schumacher, Ammar Kamil, Elizabeth McGinn, Katherine Rilett, Elizabeth Elliott, Caleb Cave, Rebecca Johnson, Kara Weishaar, Ann Anderson-Berry
BACKGROUND: Oxidative stress has been associated with adverse neonatal outcomes, and vitamin E has powerful anti-oxidant properties. Vitamin E occurs in several different isoforms which differ in their ability to modulate inflammation and oxidative stress. Therefore, the purpose of this study was to evaluate the status of α-, γ- and δ-tocopherol in maternal-infant pairs, and the impact on maternal-newborn outcomes. METHODS: Vitamin E status was evaluated in 189 mother-infant pairs...
February 20, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29493792/foetal-neonatal-and-child-vitamin-d-status-and-enamel-hypomineralization
#19
Justin T van der Tas, Marlies E C Elfrink, Annemieke C Heijboer, Fernando Rivadeneira, Vincent W V Jaddoe, Henning Tiemeier, Josje D Schoufour, Henriëtte A Moll, Edwin M Ongkosuwito, Eppo B Wolvius, Trudy Voortman
OBJECTIVES: Recent literature suggested that higher vitamin D concentrations in childhood are associated with a lower prevalence of molar incisor hypomineralization (MIH). As tooth development already starts in utero, we aimed to study whether vitamin D status during foetal, postnatal and childhood periods is associated with the presence of hypomineralized second primary molars (HSPMs) and/or MIH at the age of six. METHODS: Our study was embedded in the Generation R Study, a population-based, prospective cohort from foetal life onwards in Rotterdam, the Netherlands...
March 1, 2018: Community Dentistry and Oral Epidemiology
https://www.readbyqxmd.com/read/29472892/maternal-and-cord-blood-vitamin-d-status-and-anthropometric-measurements-in-term-newborns-at-birth
#20
Regina Wierzejska, Mirosław Jarosz, Magdalena Klemińska-Nowak, Marta Tomaszewska, Włodzimierz Sawicki, Michał Bachanek, Magdalena Siuba-Strzelińska
Introduction: Vitamin D deficiency in pregnant women may result in reduced neonatal development due to the fact that systemic vitamin D status during fetal life depends on maternal concentrations. Some authors reported significant differences in neonatal anthropometric measurements depending on maternal vitamin D concentrations. Objective: The aim of this study is to evaluate the relationship between maternal and cord blood concentrations of vitamin D and neonatal anthropometric measurements at birth...
2018: Frontiers in Endocrinology
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