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vitamine A Neonates

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https://www.readbyqxmd.com/read/28099429/vitamin-d-insufficiency-in-neonatal-hypoxic-ischemic-encephalopathy
#1
Danielle W Lowe, Bruce W Hollis, Carol L Wagner, Thomas Bass, David A Kaufman, Michael J Horgan, Laurence M Givelichian, Koravangatta Sankaran, Jerome Y Yager, Lakshmi D Katikaneni, Don Wiest, Dorothea Jenkins
BACKGROUND: Vitamin D has neuroprotective and immunomodulatory properties, and deficiency is associated with worse stroke outcomes. Little is known about effects of hypoxia-ischemia or hypothermia treatment on vitamin D status in neonates with hypoxic-ischemic encephalopathy (HIE). We hypothesized vitamin D metabolism would be dysregulated in neonatal HIE altering specific cytokines involved in Th17 activation, which might be mitigated by hypothermia. METHODS: We analyzed short term relationships between 25(OH) and 1,25(OH)2 vitamin D, vitamin D binding protein, and cytokines related to Th17 function in serum samples from a multicenter randomized controlled trial of hypothermia 33(0)C for 48h after HIE birth versus normothermia in 50 infants with moderate to severe HIE...
January 18, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28054156/parental-refusal-of-vitamin-k-and-neonatal-preventive-services-a-need-for-surveillance
#2
Lauren H Marcewicz, Joshua Clayton, Matthew Maenner, Erika Odom, Ekwutosi Okoroh, Deborah Christensen, Alyson Goodman, Michael D Warren, Julie Traylor, Angela Miller, Timothy Jones, John Dunn, William Schaffner, Althea Grant
Objectives Vitamin K deficiency bleeding (VKDB) in infants is a coagulopathy preventable with a single dose of injectable vitamin K at birth. The Tennessee Department of Health (TDH) and Centers for Disease Control and Prevention (CDC) investigated vitamin K refusal among parents in 2013 after learning of four cases of VKDB associated with prophylaxis refusal. Methods Chart reviews were conducted at Nashville-area hospitals for 2011-2013 and Tennessee birthing centers for 2013 to identify parents who had refused injectable vitamin K for their infants...
January 4, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28045436/retinol-and-%C3%AE-tocopherol-in-the-breast-milk-of-women-after-a-high-risk-pregnancy
#3
Reyna Sámano, Hugo Martínez-Rojano, Rosa M Hernández, Cristina Ramírez, María E Flores Quijano, José M Espíndola-Polis, Daniela Veruete
BACKGROUND: There is scant information about whether, after a high-risk pregnancy, breast milk provides enough vitamins for assuring satisfactory bodily reserves in newborns. OBJECTIVE: To comparatively evaluate, in women with high-risk and normal pregnancy, the concentration of retinol and α-tocopherol in breast milk. METHODS: This cross-sectional, analytical study was evaluated with reverse-phase high-performance liquid chromatography (HPLC)...
January 1, 2017: Nutrients
https://www.readbyqxmd.com/read/28026707/determinants-of-vitamin-d-status-in-pregnant-women-and-neonates
#4
Christy G Woolcott, Yves Giguère, Hope A Weiler, Anne Spencer, Jean-Claude Forest, B Anthony Armson, Linda Dodds
OBJECTIVES: Evidence suggests a beneficial effect of vitamin D on perinatal health; however, low vitamin D status is prevalent in pregnant women and neonates. The objective was to determine factors that are associated with vitamin D status of mothers in early pregnancy and neonates. METHODS: The study comprised 1,635 pregnant women from Quebec City and Halifax, Canada, 2002-2010. Vitamin D status was based on the concentration of 25-hydroxy-vitamin D [25(OH)D] determined with a chemiluminescence immunoassay in maternal sera collected at a median of 15 weeks' gestation and in neonatal cord sera at delivery...
December 27, 2016: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/28017710/a-vitamin-d-analogue-eldecalcitol-enhances-expression-of-fast-myosin-heavy-chain-subtypes-in-differentiated-c2c12-myoblasts
#5
Hideo Saito, Koshi N Kishimoto, Yu Mori, Hiroshi Okuno, Masahiko Tanaka, Eiji Itoi
BACKGROUND: Several lines of evidence indicate that the active form of vitamin D has an anabolic effect on skeletal muscle. Eldecalcitol, an analogue of the active form of vitamin D, has the potential to increase bone density and decrease fracture risk. The objective of this study was to investigate the effect of eldecalcitol in C2C12 myogenic cells. METHODS: C2C12 cells were grown to confluency and the culture medium was replaced with low-glucose DMEM containing 2% horse serum...
December 23, 2016: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28007533/vitamin-d-metabolite-concentrations-in-umbilical-cord-blood-serum-and-associations-with-clinical-characteristics-in-a-large-prospective-mother-infant-cohort-in-ireland
#6
Mairead Kiely, Sinead M O'Donovan, Louise C Kenny, Jonathan O'B Hourihane, Alan D Irvine, Deirdre M Murray
Vitamin D deficiency is widespread among mothers and neonates and quality clinical and analytical data are lacking. We used a CDC-accredited LC-MS/MS method to analyze vitamin D metabolites in cord sera from 1050 maternal-infant dyads in the prospective SCOPE Ireland Pregnancy and BASELINE Birth cohort studies, based in Cork, Ireland. The mean±SD total 25(OH)D was 34.9±18.1nmol/L; 35% of cords (50% during winter) had 25(OH)D <25nmol/L, 46% were <30nmol/L and 80% were <50nmol/L. In this predominantly white cohort, the main predictor of cord 25(OH)D [adj...
December 19, 2016: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28002587/blood-folic-acid-vitamin-b12-and-homocysteine-levels-in-pregnant-women-with-fetal-growth-restriction
#7
H L Jiang, L Q Cao, H Y Chen
Deficiencies in nutrients such as folic acid and vitamin B12 may play a role in fetal growth restriction (FGR). However, whether folic acid, vitamin B12, or homocysteine is associated with FGR in Chinese populations remains unclear. This study investigated the relationship between these nutrient deficiencies and FGR in pregnant Chinese women. We selected 116 mother and infant pairs, and categorized the neonates into the FGR, appropriate for gestational age, and large for gestational age groups. Birth weight, body length, head circumference, body mass index (BMI), and Rohrer's body index of the newborns were measured...
December 19, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27997141/neonatal-metabolomic-profiles-related-to-prenatal-arsenic-exposure
#8
Jessica E Laine, Kathryn A Bailey, Andrew F Olshan, Lisa Smeester, Zuzana Drobná, Miroslav Stýblo, Christelle Douillet, Gonzalo García-Vargas, Marisela Rubio-Andrade, Wimal Pathmasiri, Susan McRitchie, Susan J Sumner, Rebecca C Fry
Prenatal inorganic arsenic (iAs) exposure is associated with health effects evident at birth and later in life. An understanding of the relationship between prenatal iAs exposure and alterations in the neonatal metabolome could reveal critical molecular modifications, potentially underpinning disease etiologies. In this study, nuclear magnetic resonance (NMR) spectroscopy-based metabolomic analysis was used to identify metabolites in neonate cord serum associated with prenatal iAs exposure in participants from the Biomarkers of Exposure to ARsenic (BEAR) pregnancy cohort, in Gómez Palacio, Mexico...
January 3, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/27976660/assessment-of-newborn-care-corners-in-selected-public-health-facilities-in-bihar
#9
Monika Chauhan, Jyoti Sharma, Preeti Negandhi, Siddharth Reddy, Ghanashyam Sethy, Sutapa B Neogi
BACKGROUND: A functional newborn care corner (NBCC) is critical to provide immediate care to newborns including resuscitation, warmth, and initial care to sick newborns. NBCC provides an acceptable environment for all infants at birth, and it is mandatory for all delivery points at all levels in the health system including operation theaters. OBJECTIVE: The objective of this study was to find the status of availability of NBCCs and service provision in selected public health facilities of Bihar...
October 2016: Indian Journal of Public Health
https://www.readbyqxmd.com/read/27941597/maternal-vitamin-d-status-and-adverse-birth-outcomes-in-children-from-rural-western-kenya
#10
Eunice N Toko, Odada P Sumba, Ibrahim I Daud, Sidney Ogolla, Maxwel Majiwa, Jesse T Krisher, Collins Ouma, Arlene E Dent, Rosemary Rochford, Saurabh Mehta
Maternal plasma 25-hydroxyvitamin D (25(OH)D) status and its association with pregnancy outcomes in malaria holoendemic regions of sub-Saharan Africa is poorly defined. We examined this association and any potential interaction with malaria and helminth infections in an ongoing pregnancy cohort study in Kenya. The association of maternal plasma 25(OH)D status with pregnancy outcomes and infant anthropometric measurements at birth was determined in a subset of women (n = 63). Binomial and linear regression analyses were used to examine associations between maternal plasma 25(OH)D and adverse pregnancy outcomes...
December 7, 2016: Nutrients
https://www.readbyqxmd.com/read/27931209/prevalence-and-risk-factors-for-vitamin-d-insufficiency-and-deficiency-at-birth-and-associated-outcome
#11
Ian Marshall, Rajeev Mehta, Charletta Ayers, Smita Dhumal, Anna Petrova
BACKGROUND: Occurrence and consequence of cord blood (CB) vitamin D insufficiency/deficiency has not been adequately explored despite rising concern regarding this topic in pediatrics. This study was designed to determine the rate, maternal risk factors, and clinical outcomes in infants in association with vitamin D insufficient/deficient status at birth. METHODS: American Academy of Pediatrics (AAP) defined levels (ng/mL) were utilized to categorize the vitamin D status in CB samples as deficient (5-15), insufficient (16-20), and sufficient (21-100)...
December 8, 2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27916927/vitamin-b12-status-among-pregnant-women-in-the-uk-and-its-association-with-obesity-and-gestational-diabetes
#12
Nithya Sukumar, Hema Venkataraman, Sean Wilson, Ilona Goljan, Selvin Selvamoni, Vinod Patel, Ponnusamy Saravanan
BACKGROUND: To evaluate vitamin B12 and folate status in pregnancy and their relationship with maternal obesity, gestational diabetes mellitus (GDM), and offspring birthweight. METHODS: A retrospective case-control study of 344 women (143 GDM, 201 no-GDM) attending a district general hospital and that had B12 and folate levels measured in the early 3rd trimester was performed. Maternal history including early pregnancy body mass index (BMI) and neonatal data (birthweight, sex, and gestational age) was recorded for all subjects...
December 1, 2016: Nutrients
https://www.readbyqxmd.com/read/27912735/the-effect-of-early-measles-vaccination-at-4-5%C3%A2-months-of-age-on-growth-at-9-and-24%C3%A2-months-of-age-in-a-randomized-trial-in-guinea-bissau
#13
S M Rasmussen, S Biering-Sørensen, S Byberg, A Andersen, M Bjerregaard-Andersen, A Rodrigues, C S Benn, C L Martins, P Aaby
BACKGROUND: Providing an early, additional measles vaccine (MV) at 4.5 months of age has been shown to reduce child mortality in low-income countries. We studied the effects on growth at 9 and 24 months of age. METHODS: A randomized controlled trial was conducted in Guinea-Bissau from 2003-2007 including 6,648 children. Children were randomized 1:1:1 to receive Edmonston-Zagreb measles vaccine at 4.5 and 9 months of age (group A), no vaccine at 4.5 months and Edmonston-Zagreb measles vaccine at 9 months (group B), or no vaccine at 4...
December 3, 2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27904548/the-effect-of-vitamin-d-supplementation-on-gestational-diabetes-in-high-risk-women-results-from-a-randomized-placebo-controlled-trial
#14
Shole Shahgheibi, Fariba Farhadifar, Bahar Pouya
BACKGROUND: Vitamin D deficiency is common in pregnancy, leading to increase in the frequency of preeclampsia, cesarean delivery, neonatal bacterial vaginosis, and gestational diabetes. The current study was designed and implemented to investigate the effect of vitamin D during the first and second trimesters of pregnancy in reducing the risk of gestational diabetes mellitus (GDM) in women who are at high risk [history of GDM, birth macrosomia, family history, and high body mass index (BMI)]...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27903815/neonatal-vitamin-d-status-and-risk-of-multiple-sclerosis-a-population-based-case-control-study
#15
Nete Munk Nielsen, Kassandra L Munger, Nils Koch-Henriksen, David M Hougaard, Melinda Magyari, Kristian T Jørgensen, Marika Lundqvist, Jacob Simonsen, Tine Jess, Arieh Cohen, Egon Stenager, Alberto Ascherio
OBJECTIVE: As previous research has suggested that exposure to vitamin D insufficiency in utero may have relevance for the risk of multiple sclerosis (MS), we aimed to examine the direct association between level of neonatal vitamin D and risk of MS. METHODS: We carried out a matched case-control study. Dried blood spots samples (DBSS) belonging to 521 patients with MS were identified in the Danish Newborn Screening Biobank. For every patient with MS, 1-2 controls with the same sex and birth date were retrieved from the Biobank (n = 972)...
January 3, 2017: Neurology
https://www.readbyqxmd.com/read/27900779/mosaic-nras-q61r-mutation-in-a-child-with-giant-congenital-melanocytic-naevus-epidermal-naevus-syndrome-and-hypophosphataemic-rickets
#16
R Ramesh, N Shaw, E K Miles, B Richard, I Colmenero, C Moss
The association of hypophosphataemic rickets with verrucous epidermal naevus (EN) and elevated fibroblast growth factor 23 levels is known as cutaneous-skeletal hypophosphataemia syndrome (CSHS), and can be caused by somatic activating mutations in RAS genes. We report a unique patient with CSHS associated with giant congenital melanocytic naevus (CMN), neurocutaneous melanosis and EN syndrome, manifesting as facial linear sebaceous naevus, developmental delay and ocular dermoids. An activating mutation Q61R in the NRAS gene was found in affected skin and ocular tissue but not blood, implying that the disparate manifestations are due to a multilineage activating mutation (mosaic RASopathy)...
January 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/27898964/evaluating-the-impact-of-maternal-vitamin-d-supplementation-i-sow-performance-serum-vitamin-metabolites-and-neonatal-muscle-characteristics
#17
J R Flohr, J C Woodworth, J R Bergstrom, M D Tokach, S S Dritz, R D Goodband, J M DeRouchey
In Exp. 1, 56 gestating sows (PIC 1050; 35 d postinsemination) were used in a 30-d trial to determine serum 25(OH)D response to increasing concentrations of dietary vitamin D. Sows were randomly allotted to 1 of 7 dietary D treatments (200, 800, 1,600, 3,200, 6,400, 12,800, or 25,600 IU of added D per kilogram of complete diet) with 8 sows per treatment. Increasing D increased (quadratic; < 0.001) serum 25(OH)D with the response depicted by the prediction equation: serum 25(OH)D, ng/mL = 35.1746 + (0.002353 × dietary D, IU/d) - (0...
November 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27895322/gestational-vitamin-d-deficiency-and-autism-related-traits-the-generation-r-study
#18
A A E Vinkhuyzen, D W Eyles, T H J Burne, L M E Blanken, C J Kruithof, F Verhulst, V W Jaddoe, H Tiemeier, J J McGrath
There is intense interest in identifying modifiable risk factors associated with autism-spectrum disorders (ASD). Autism-related traits, which can be assessed in a continuous fashion, share risk factors with ASD, and thus can serve as informative phenotypes in population-based cohort studies. Based on the growing body of research linking gestational vitamin D deficiency with altered brain development, this common exposure is a candidate modifiable risk factor for ASD and autism-related traits. The association between gestational vitamin D deficiency and a continuous measure of autism-related traits at ~6 years (Social Responsiveness Scale; SRS) was determined in a large population-based cohort of mothers and their children (n=4229)...
November 29, 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/27889736/vitamin-d-and-metabolic-bone-parameters-in-preterm-neonates
#19
Amitoj Singh Chhina, Arvind Shenoi, Namrata Nagendra, Nilesh Rao, Malathi Raja
We measured serum levels of 25-hydroxy vitamin D (25(OH) D) in 79 preterm neonates (?32 wk), and correlated it with serum ionized calcium (Ca++) levels at 48-72 h and serum phosphorus and alkaline phosphatase levels at 2-3 weeks of age. The mean (SD) 25 (OH)D level was 14.8 (7.0) ng/mL. 25(OH)D levels had a weak positive correlation with Ca++ (r=0.299) and phosphorus (r=0.186), and a negative correlation with alkaline phosphatase (r=-0.523).
November 15, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27878777/vitamin-k-supplementation-to-prevent-hemorrhagic-morbidity-and-mortality-of-newborns-in-india-and-china
#20
REVIEW
Rajesh Kumar Rai, Jing Luo, Theodore Herzl Tulchinsky
BACKGROUND: Vitamin K deficiency bleeding (VKDB) can cause prolonged and bleeding (intracranial hemorrhage) among newborns, which can be life-threatening or lead to long-term morbidity. The aim of this review article is to reiterate empirical evidence to support the argument that vitamin K should be mandatory for newborns in India and China, as well as in other countries with a high burden of neonatal deaths. DATA SOURCES: Studies were integrated from the PubMed/MEDLINE database search, as well as related literature available elsewhere...
February 2017: World Journal of Pediatrics: WJP
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