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Maureen O'Sullivan
Since its foundation by remarkably talented and insightful individuals, prominently including Pepper Dehner, pediatric soft tissue tumor pathology has developed at an immense rate. The morphologic classification of tumoral entities has extensively been corroborated, but has also evolved with refinement or realignment of these classifications, through accruing molecular data, with many derivative ancillary diagnostic assays now already well-established. Tumors of unclear histogenesis, classically morphologically undifferentiated, are prominent amongst pediatric sarcomas, however, the classes of undifferentiated round- or spindle-cell-tumors-not-otherwise-specified are being dismantled gradually with the identification of their molecular underpinnings...
September 5, 2016: Seminars in Diagnostic Pathology
Fabian Sanchis-Gomar, Helios Pareja Galeano, Jose A Rodriguez-Marroyo, Jos J de Koning, Alejandro Lucia, Carl Foster
Despite some advances, how the millions of variations in the human genome influence athletic performance (especially in endurance events) remains largely unknown, and no single genetic test can really predict sports talent. However, there is experimental evidence coming from animal research that selecting for even a simple characteristic like running ability, can produce comparatively large and rapid changes in performance. That such selection has not been specifically documented in humans is more evidence of the limits of physiology-archeology than of the unlikelihood of selection for physical abilities...
October 13, 2016: International Journal of Sports Physiology and Performance
Stephanie A Kovalchik, Michael K Bane, Machar Reid
Official rankings are the most common measure of success in professional women's tennis. Despite their importance for earning potential and tournament seeding, little is known about ranking trajectories of female players and their influence on career success. Our objective was to conduct a comprehensive study of the career progression of elite female tennis talent. The study examined the ranking trajectories of the top 250 female professionals between 1990 and 2015. Using regression modelling of yearly peak rankings, we found a strong association between the shape of the ranking trajectory and the highest career ranking earned...
October 13, 2016: Journal of Sports Sciences
Chunxiao Li, Chee Keng John Wang, Do Young Pyun
Guided by Deci and Ryan's (2000) self-determination theory, this survey study aimed to examine the effects of the talent development environmental factors on athlete burnout. Talented adolescent athletes (n = 691) filled out a survey form measuring the talent development environmental factors, needs satisfaction and burnout. The findings showed that three talent environmental factors (i.e., long-term development focus, holistic quality preparation and communication) were negative predictors of burnout via needs satisfaction...
October 11, 2016: Journal of Sports Sciences
Matthew Tredrea, Ben Dascombe, Colin E Sanctuary, Aaron Terrence Scanlan
This study aimed to identify attributes that discriminate selected from non-selected players and predict selection into a rugby league development programme in older adolescent players. Anthropometric, performance and psychological attributes were measured in under-16 (N = 100) and under-18 (N = 60) rugby league players trialling for selection into a development programme with a professional Australian club. Sprint times (P < 0.001), predicted VO2max (P = 0.002) and push-ups1 min (P = 0.004) were superior in selected under-16 players, and sprint times (P ≤ 0...
October 11, 2016: Journal of Sports Sciences
Jiahui Wang, Matthew H Schneps, Pavlo D Antonenko, Chen Chen, Marc Pomplun
This study explores a proposition that individuals with dyslexia develop enhanced peripheral vision to process visual-spatial information holistically. Participants included 18 individuals diagnosed with dyslexia and 18 who were not. The experiment used a comparative visual search design consisting of two blocks of 72 trials. Each trial presented two halves of the display each comprising three kinds of shapes in three colours to be compared side-by-side. Participants performed a conjunctive search to ascertain whether the two halves were identical...
October 7, 2016: Dyslexia: the Journal of the British Dyslexia Association
Vinay Kansal, Sudhir Nagpal
OBJECTIVES: To report a rare case of delayed Type IIIb endoleak secondary to fabric tear following implantation of a Medtronic Talent endovascular device. METHODS: A 83-year old gentleman underwent elective endovascular aneurysm repair for infrarenal abdominal aortic aneurysm with a Medtronic bifurcated stent graft in 2008. RESULTS: Seven years after the initial repair, imaging surveillance revealed significant endoleak and brisk aneurysm sac expansion due to Type IIIb endoleak secondary to endograft limb fabric tear...
2016: SAGE Open Med Case Rep
Tamara Kramer, Barbara Ch Huijgen, Marije T Elferink-Gemser, Chris Visscher
PURPOSE: To analyze how physical fitness (PF) improves in elite junior tennis players related to age, maturity, and performance level. METHODS: Elite junior tennis players (n=113 boys, n=83 girls) divided by performance level were monitored longitudinally from U14 to U16. Maturity, upper and lower body power, speed, and agility were measured during subsequent competitive seasons. Improvement was analyzed per sex using multilevel analysis. RESULTS: PF components for boys and girls improved over age (U14-U16) (ES ...
October 5, 2016: Pediatric Exercise Science
Mary Ruth Coleman
Hands-on science is the ideal platform for observing young children's ability to solve problems, think deeply, and use their creative ingenuity to explore the world around them. Science is naturally interesting and offers authentic reasons to read for information and use math skills to collect, compile, and analyze data. This chapter will share one approach to nurturing and recognizing young children with high-potential: U-STARS∼PLUS (Using Science, Talents, and Abilities to Recognize Students∼Promoting Learning for Underrepresented Students)...
August 2016: Annals of the New York Academy of Sciences
Weibin Wang, Taiping Zhang, Wenjing Zhao, Lai Xu, Yu Yang, Quan Liao, Yupei Zhao
Immunogenic membrane antigens associated with multiple biological functions of human cancer cells, have significant value in molecule diagnosis and targeted therapy. Here we screened immunogenic membrane antigens in pancreatic cancer by immunobloting IgG purified from sera of 66 pancreatic cancer patients with membrane proteins separated from two-dimensional PAGE of human pancreatic cancer cell line SWl990, and identified voltage-dependent anion channel 1 (VDAC1) as one of the potential immunogenic membrane antigens...
2016: Scientific Reports
Chao-Yu Liu, Chen-Sung Lin, Chia-Chuan Liu
The development of minimally-invasive surgery of the thorax began in the 1990s, but not until the recent decade did we see dramatic improvements in patient care and refinement of technique. The current generation has witnessed the evolution from traditional thoracotomy, to a single-port, non-intubated thoracoscopic approach. The investigation of subxiphoid single-port, transumbilical approach, and natural orifice transluminal endoscopic surgery (NOTES) in animal model are also undergoing. In Taiwan, several talented young surgeons have vigorously devoted their ideas and innovations to this field, making the Taiwan surgical society vivid and prosperous...
August 2016: Journal of Thoracic Disease
Li Xu, Hao Ren, Guangang Gao, Linkang Zhou, Muhammad Arshad Malik, Peng Li
Metabolism refers to a chain of chemical reactions converting food/fuel into energy to conduct cellular processes, including the synthesis of the building blocks of the body, such as proteins, lipids, nucleic acids, and carbohydrates, and the elimination of nitrogenous wastes. Metabolic chain reactions are catalyzed by various enzymes that are orchestrated in specific pathways. Metabolic pathways are important for organisms to grow and reproduce, maintain their structures, and respond to their environments...
September 20, 2016: IUBMB Life
Minimol Kulakkottu Scaria
Cohesive interprofessional teamwork is essential to successful healthcare services. Interprofessional teamwork is the means by which different healthcare professionals - with diverse knowledge, skills and talents - collaborate to achieve a common goal. Several interventions are available to improve teamwork in the healthcare setting. This article explores the role of care pathways in improving interprofessional teamwork. Care pathways enhance teamwork by promoting coordination, collaboration, communication and decision making to achieve optimal healthcare outcomes...
August 24, 2016: Nursing Standard
Kunihiko Suzuki
In this hybrid of a personal essay and a subjective review, I am attempting to convey the sense of an adventure I myself experienced in exploring various aspects of Krabbe disease, which occupied a significant portion of my life as a biomedical researcher. This is meant to be a personal summary, and I have no pretense of this being an objective scholarly review. Since the first description of the disease by Krabbe 100 years ago, knowledge about the disease has advanced significantly. The main contributions from my laboratory, always the fruits of dedicated efforts of talented young colleagues, include the identification of the genetic defect as deficiency of galactosylceramidase, proposal of the psychosine hypothesis as the pathogenetic mechanism to explain the unique phenotypic characteristics of the disease, detailed delineations of the substrate specificities of the two lysosomal β-galactosidases, discovery of the twitcher mutant as a convenient and useful mouse model, and identification of saposin A as a specific galactosylceramide activator protein and as the second causative gene for globoid cell leukodystrophy...
November 2016: Journal of Neuroscience Research
Lara L Jones, Gregory A Norville, A Michelle Wright
Across two studies, we investigated the influence of narcissism and self-esteem along with gender on phenomenological ratings across the four subscales of the Autobiographical Memory Questionnaire (AMQ; impact, recollection, rehearsal, and belief). Memory cues varied in valence (positive vs. negative) and agency (agentic vs. communal). In Study 2, we used different memory cues reflecting these four Valence by Agency conditions and additionally investigated retrieval times for the autobiographical memories (AMs)...
September 16, 2016: Memory
Hugo Maciejewski, Abderrahmane Rahmani, Frédéric Chorin, Julien Lardy, Caroline Giroux, Sébastien Ratel
PURPOSE: The aim of the present study was to determine whether the anaerobic performance assessed by a modified Wingate test could account for the 1,500-m rowing ergometer performance in young competitive rowers. METHODS: Fourteen national-level adolescent rowers performed on a rowing ergometer i) a 30-s all-out exercise (i.e., modified Wingate test) and ii) a 1,500-m all-out exercise (i.e., rowing performance). For each of these two exercises, the mean power output was considered as the main performance criterion (PWIN and P1500, respectively)...
August 19, 2016: Pediatric Exercise Science
Dante D Dixson, Frank C Worrell, Paula Olszewski-Kubilius, Rena F Subotnik
In this study, we examined the contributions of grit, hope, and academic self-efficacy to academic achievement in a sample of 609 academically talented students ranging in age from 10 to 18 years. Our hypothesis was that these variables would predict academic achievement above and beyond the contributions of demographic variables and perceived ability. After establishing the reliability and structural validity of scores for the three constructs in this sample, regression analyses indicated that hope and academic self-efficacy were predictors of perceived ability and that academic self-efficacy was the most robust predictor of academic achievement...
August 2016: Annals of the New York Academy of Sciences
S R Stewart, P W Barone, A Bellisario, C L Cooney, P A Sharp, A J Sinskey, S Natesan, S L Springs
Despite the rapid pace of biomedical innovation, R&D productivity in the pharmaceutical industry has not improved broadly. Increasingly, firms need to leverage new approaches to product development and commercial execution, while maintaining adaptability to rapid changes in the marketplace and in biomedical science. Firms are also seeking ways to capture some of the talent, infrastructure, and innovation that depends on federal R&D investment. As a result, a major transition to external innovation is taking place across the industry...
September 12, 2016: Clinical Pharmacology and Therapeutics
A Meder, M Lammerding-Köppel, S Zundel, U Stöckle, C Bahrs, C Gonser
Background: There is a serious lack of young doctors in trauma surgery, which has intensified in recent years. The reasons are complex. Studies have shown that the interest in starting a career in surgery significantly decreases during medical school. To counteract the lack of young talent in the clinic, interest in the subject should be aroused in medical school. The aim of the present study was to evaluate current teaching at our university, where trauma surgery is a curricular subject with mandatory attendance for all medical students...
September 9, 2016: Zeitschrift Für Orthopädie und Unfallchirurgie
Thomas Pfeiffer, Elena Avignone, U Valentin Nägerl
Recently microglia, the resident immune cells of the brain, have been recognized as multi-tasking talents that are not only essential in the diseased brain, but also actively contribute to synaptic circuit remodeling during normal brain development. It is well established that microglia dynamically scan their environment and thereby establish transient physical contacts with neuronal synapses, which may allow them to sense and influence synaptic function. However, it is unknown whether and how the morphological dynamics of microglia and their physical interactions with synapses are affected by the induction of synaptic plasticity in the adult brain...
2016: Scientific Reports
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