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https://www.readbyqxmd.com/read/29787575/safety-of-intravenous-alteplase-within-4-5-hours-for-patients-awakening-with-stroke-symptoms
#1
Victor C Urrutia, Roland Faigle, Steven R Zeiler, Elisabeth B Marsh, Mona Bahouth, Mario Cerdan Trevino, Jennifer Dearborn, Richard Leigh, Susan Rice, Karen Lane, Mustapha Saheed, Peter Hill, Rafael H Llinas
BACKGROUND: Up to 25% of acute stroke patients first note symptoms upon awakening. We hypothesized that patients awaking with stroke symptoms may be safely treated with intravenous alteplase (IV tPA) using non-contrast head CT (NCHCT), if they meet all other standard criteria. METHODS: The SAfety of Intravenous thromboLytics in stroke ON awakening (SAIL ON) was a prospective, open-label, single treatment arm, pilot safety trial of standard dose IV tPA in patients who presented with stroke symptoms within 0-4...
2018: PloS One
https://www.readbyqxmd.com/read/29787549/long-term-patient-centered-outcomes-of-lower-extremity-vascular-trauma
#2
Zane B Perkins, Barbaros Yet, Simon Glasgow, William Marsh, Nigel R M Tai, Todd E Rasmussen
OBJECTIVE: To describe the long-term outcomes of military lower extremity vascular injuries, and the decision-making of surgeons treating these injuries. BACKGROUND: Lower extremity vascular trauma is an important cause of preventable death and severe disability, and decisions on amputation or limb salvage can be difficult. Additionally, the complexity of the condition is not amenable to controlled study, and there is limited data to guide clinical decision-making and establish sensible treatment expectations during rehabilitation...
May 4, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29784263/tertiary-care-referrals-for-fractures-in-children
#3
Jennifer K Marsh, David J Murray, Anshuman Sharma, Kavya Narayana Reddy, Alyssa Naes
PURPOSE: With limited local access to pediatric subspecialty care outside major metropolitan areas, tertiary care hospitals treat many children originally seen at outside facilities for relatively brief but urgent surgical procedures. This referral-based care imposes significant financial and psychological stress on the families. DESIGN: Prospective, survey methodology was used. METHODS: Families of children aged 0-18 years admitted to the St...
June 2018: Journal of Perianesthesia Nursing: Official Journal of the American Society of PeriAnesthesia Nurses
https://www.readbyqxmd.com/read/29784027/recommendations-for-application-of-haemophilus-influenzae-pcr-diagnostics-to-respiratory-specimens-for-children-living-in-northern-australia-a-retrospective-re-analysis
#4
Jemima Beissbarth, Michael J Binks, Robyn L Marsh, Anne B Chang, Amanda J Leach, Heidi C Smith-Vaughan
OBJECTIVE: Haemophilus haemolyticus can be misidentified as nontypeable Haemophilus influenzae (NTHi) due to their phenotypic similarities in microbiological culture. This study aimed to determine the prevalence of misidentified NTHi in respiratory specimens from children living in northern Australia. RESULTS: Among respiratory specimens collected in studies between 2010 and 2013, retrospective PCR analysis found that routine culture misidentified H. haemolyticus as NTHi in 0...
May 21, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29783949/gene-copy-number-variation-in-natural-populations-of-plasmodium-falciparum-in-eastern-africa
#5
Joan Simam, Martin Rono, Joyce Ngoi, Mary Nyonda, Sachel Mok, Kevin Marsh, Zbynek Bozdech, Margaret Mackinnon
BACKGROUND: Gene copy number variants (CNVs), which consist of deletions and amplifications of single or sets of contiguous genes, contribute to the great diversity in the Plasmodium falciparum genome. In vitro studies in the laboratory have revealed their important role in parasite fitness phenotypes such as red cell invasion, transmissibility and cytoadherence. Studies of natural parasite populations indicate that CNVs are also common in the field and thus may facilitate adaptation of the parasite to its local environment...
May 21, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29781065/correction-to-use-of-genetic-testing-for-primary-immunodeficiency-patients
#6
Jennifer R Heimall, David Hagin, Joud Hajjar, Sarah E Henrickson, Hillary S Hernandez-Trujillo, Yuval Itan, Lisa Kobrynski, Kenneth Paris, Troy R Torgerson, James W Verbsky, Richard L Wasserman, Elena W Y Hsieh, Jack J Bleesing, Janet S Chou, Monica G Lawrence, Rebecca A Marsh, Sergio D Rosenzweig, Jordan S Orange, Roshini S Abraham
The original version of this article unfortunately contained mistakes in some of the author names and affiliations. The correct list of author names and affiliations is below, with the corrections in bold.
May 21, 2018: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/29780171/is-saltmarsh-restoration-success-constrained-by-matching-natural-environments-or-altered-succession-a-test-using-niche-models
#7
Martin J P Sullivan, Anthony J Davy, Alastair Grant, Hannah L Mossman
Restored habitats, such as saltmarsh created through managed realignment, sometimes fail to meet targets for biological equivalence with natural reference sites. Understanding why this happens is important in order to improve restoration outcomes.Elevation in the tidal frame and sediment redox potential are major controls on the distribution of saltmarsh plants. We use niche models to characterize 10 species' responses to these, and test whether differences in species occurrence between restored and natural saltmarshes in the UK result from failure to recreate adequate environmental conditions...
May 2018: Journal of Applied Ecology
https://www.readbyqxmd.com/read/29778836/interrogation-of-mammalian-protein-complex-structure-function-and-membership-using-genome-scale-fitness-screens
#8
Joshua Pan, Robin M Meyers, Brittany C Michel, Nazar Mashtalir, Ann E Sizemore, Jonathan N Wells, Seth H Cassel, Francisca Vazquez, Barbara A Weir, William C Hahn, Joseph A Marsh, Aviad Tsherniak, Cigall Kadoch
Protein complexes are assemblies of subunits that have co-evolved to execute one or many coordinated functions in the cellular environment. Functional annotation of mammalian protein complexes is critical to understanding biological processes, as well as disease mechanisms. Here, we used genetic co-essentiality derived from genome-scale RNAi- and CRISPR-Cas9-based fitness screens performed across hundreds of human cancer cell lines to assign measures of functional similarity. From these measures, we systematically built and characterized functional similarity networks that recapitulate known structural and functional features of well-studied protein complexes and resolve novel functional modules within complexes lacking structural resolution, such as the mammalian SWI/SNF complex...
May 14, 2018: Cell Systems
https://www.readbyqxmd.com/read/29777376/comprehensive-molecular-diagnosis-of-epstein-barr-virus-associated-lymphoproliferative-diseases-using-next-generation-sequencing
#9
Shintaro Ono, Manabu Nakayama, Hirokazu Kanegane, Akihiro Hoshino, Saeko Shimodera, Hirofumi Shibata, Hisanori Fujino, Takahiro Fujino, Yuta Yunomae, Tsubasa Okano, Motoi Yamashita, Takahiro Yasumi, Kazushi Izawa, Masatoshi Takagi, Kohsuke Imai, Kejian Zhang, Rebecca Marsh, Capucine Picard, Sylvain Latour, Osamu Ohara, Tomohiro Morio
Epstein-Barr virus (EBV) is associated with several life-threatening diseases, such as lymphoproliferative disease (LPD), particularly in immunocompromised hosts. Some categories of primary immunodeficiency diseases (PIDs) including X-linked lymphoproliferative syndrome (XLP), are characterized by susceptibility and vulnerability to EBV infection. The number of genetically defined PIDs is rapidly increasing, and clinical genetic testing plays an important role in establishing a definitive diagnosis. Whole-exome sequencing is performed for diagnosing rare genetic diseases, but is both expensive and time-consuming...
May 18, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/29775060/distinct-populations-in-spin-label-epr-spectra-from-nitroxides
#10
Derek Marsh
It is not possible to reproduce simulations of nitroxide spin-label EPR spectra published in J. Phys. Chem. 88, 3454-3465 (1984), when using the motional model and parameters given in that paper. Instead of the apparent two-component line shapes claimed, the spectra resemble single-component powder patterns expected from axially anisotropic, partial motional-averaging (a situation familiar for chain-labelled lipids in nonaligned fluid membranes). This is because: (i) the nitroxide z-axis is inclined at a fixed angle to the principal diffusion axis, and (ii) motion perpendicular to the principal diffusion axis is so slow as to approximate a powder distribution...
May 18, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29774388/withholding-or-withdrawing-of-life-sustaining-therapy-in-older-adults-%C3%A2-80-years-admitted-to-the-intensive-care-unit
#11
Bertrand Guidet, Hans Flaatten, Ariane Boumendil, Alessandro Morandi, Finn H Andersen, Antonio Artigas, Guido Bertolini, Maurizio Cecconi, Steffen Christensen, Loredana Faraldi, Jesper Fjølner, Christian Jung, Brian Marsh, Rui Moreno, Sandra Oeyen, Christina Agwald Öhman, Bernardo Bollen Pinto, Ivo W Soliman, Wojciech Szczeklik, Andreas Valentin, Ximena Watson, Tilemachos Zafeiridis, Dylan W De Lange
PURPOSE: To document and analyse the decision to withhold or withdraw life-sustaining treatment (LST) in a population of very old patients admitted to the ICU. METHODS: This prospective study included intensive care patients aged ≥ 80 years in 309 ICUs from 21 European countries with 30-day mortality follow-up. RESULTS: LST limitation was identified in 1356/5021 (27.2%) of patients: 15% had a withholding decision and 12.2% a withdrawal decision (including those with a previous withholding decision)...
May 17, 2018: Intensive Care Medicine
https://www.readbyqxmd.com/read/29774037/plant-sediment-interactions-in-salt-marshes-an-optode-imaging-study-of-o-2-ph-and-co-2-gradients-in-the-rhizosphere
#12
Ketil Koop-Jakobsen, Peter Mueller, Robert J Meier, Gregor Liebsch, Kai Jensen
In many wetland plants, belowground transport of O2 via aerenchyma tissue and subsequent O2 loss across root surfaces generates small oxic root zones at depth in the rhizosphere with important consequences for carbon and nutrient cycling. This study demonstrates how roots of the intertidal salt-marsh plant Spartina anglica affect not only O2 , but also pH and CO2 dynamics, resulting in distinct gradients of O2 , pH, and CO2 in the rhizosphere. A novel planar optode system (VisiSens TD® , PreSens GmbH) was used for taking high-resolution 2D-images of the O2 , pH, and CO2 distribution around roots during alternating light-dark cycles...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29769365/testing-the-heat-dissipation-limit-theory-in-a-breeding-passerine
#13
Jan-Åke Nilsson, Andreas Nord
The maximum work rate of animals has recently been suggested to be determined by the rate at which excess metabolic heat generated during work can be dissipated (heat dissipation limitation (HDL) theory). As a first step towards testing this theory in wild animals, we experimentally manipulated brood size in breeding marsh tits ( Poecile palustris ) to change their work rate. Parents feeding nestlings generally operated at above-normal body temperatures. Body temperature in both males and females increased with maximum ambient temperature and with manipulated work rate, sometimes even exceeding 45°C, which is close to suggested lethal levels for birds...
May 16, 2018: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29769054/factors-associated-with-social-participation-amongst-elders-in-rural-sri-lanka-a-cross-sectional-mixed-methods-analysis
#14
Celeste Marsh, Paul A Agius, Gamini Jayakody, Roshan Shajehan, Chandima Abeywickrema, Kelly Durrant, Stanley Luchters, Wendy Holmes
BACKGROUND: Populations of low and middle-income countries are ageing rapidly; there is a need for policies that support an increase in the duration of old age lived in good health. There is growing evidence that social participation protects against morbidity and mortality, but few studies explore patterns of social participation. Analysis of baseline quantitative and qualitative data from a trial of the impact of Elders' Clubs on health and well-being in the hill country of Sri Lanka provided an opportunity to better understand the extent of, and influences on, social participation among elders...
May 16, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29769033/case-report-on-pathogenetic-link-between-gluten-and-iga-nephropathy
#15
Stefano Costa, Giovanni Currò, Salvatore Pellegrino, Maria Cristina Lucanto, Giovanni Tuccari, Antonio Ieni, Giuseppina Visalli, Giuseppe Magazzù, Domenico Santoro
BACKGROUND: A relationship between IgA nephropathy (IgAN) and celiac disease (CD) has been reported. We show the pathogenetic link for the first time. CASE PRESENTATION: A 39-year-old man with cystic fibrosis (CF) and CF-related diabetes started to present gross hematuria, back pain and headache. At admission, laboratory analysis showed increase in serum creatinine of 1.5 mg/dl, together with hematuria and mild proteinuria (1 g/24 h). He underwent a renal biopsy to investigate the cause of hematuria and renal failure...
May 16, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29767843/how-i-treat-primary-haemophagocytic-lymphohistiocytosis
#16
REVIEW
Rebecca A Marsh, Elie Haddad
Primary haemophagocytic lymphohistiocytosis (HLH) diseases are a collection of inherited genetic disorders that cause the syndrome of HLH. Great advances have been made in the last 20 years with regard to the discovery of many of the genetic aetiologies of disease. Several advances have also been made on the clinical stage. Accurate screening diagnostics for primary HLH diseases that are superior to traditional Natural Killer cell function testing have been developed and are now available in many countries...
May 16, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29764916/adults-with-intellectual-disabilities-experience-shame-that-leads-to-psychological-distress-and-mental-illness-that-requires-assessment-and-treatment
#17
Michael Brown, Lynne Marsh
No abstract text is available yet for this article.
May 15, 2018: Evidence-based Nursing
https://www.readbyqxmd.com/read/29764876/integrated-versus-non-integrated-peripheral-intravenous-catheter-which-is-the-most-effective-system-for-peripheral-intravenous-catheter-management-the-optimum-study-a-randomised-controlled-trial-protocol
#18
Maria Isabel Castillo, Emily Larsen, Marie Cooke, Nicole M Marsh, Marianne C Wallis, Julie Finucane, Peter Brown, Gabor Mihala, Peter J Carr, Joshua Byrnes, Rachel Walker, Prudence Cable, Li Zhang, Candi Sear, Gavin Jackson, Anna Rowsome, Alison Ryan, Julie C Humphries, Susan Sivyer, Kathy Flanigan, Claire M Rickard
INTRODUCTION: Peripheral intravenous catheters (PIVCs) are frequently used in hospitals. However, PIVC complications are common, with failures leading to treatment delays, additional procedures, patient pain and discomfort, increased clinician workload and substantially increased healthcare costs. Recent evidence suggests integrated PIVC systems may be more effective than traditional non-integrated PIVC systems in reducing phlebitis, infiltration and costs and increasing functional dwell time...
May 14, 2018: BMJ Open
https://www.readbyqxmd.com/read/29760911/strong-associations-between-plant-genotypes-and-bacterial-communities-in-a-natural-salt-marsh
#19
Gregory P Zogg, Steven E Travis, Daniel A Brazeau
Although microbial communities have been shown to vary among plant genotypes in a number of experiments in terrestrial ecosystems, relatively little is known about this relationship under natural conditions and outside of select model systems. We reasoned that a salt marsh ecosystem, which is characterized by twice-daily flooding by tides, would serve as a particularly conservative test of the strength of plant-microbial associations, given the high degree of abiotic regulation of microbial community assembly resulting from alternating periods of inundation and exposure...
May 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29760670/validating-the-copenhagen-psychosocial-questionnaire-copsoq-ii-using-set-esem-identifying-psychosocial-risk-factors-in-a-sample-of-school-principals
#20
Theresa Dicke, Herbert W Marsh, Philip Riley, Philip D Parker, Jiesi Guo, Marcus Horwood
School principals world-wide report high levels of strain and attrition resulting in a shortage of qualified principals. It is thus crucial to identify psychosocial risk factors that reflect principals' occupational wellbeing. For this purpose, we used the Copenhagen Psychosocial Questionnaire (COPSOQ-II), a widely used self-report measure covering multiple psychosocial factors identified by leading occupational stress theories. We evaluated the COPSOQ-II regarding factor structure and longitudinal, discriminant, and convergent validity using latent structural equation modeling in a large sample of Australian school principals ( N = 2,049)...
2018: Frontiers in Psychology
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