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https://www.readbyqxmd.com/read/28936626/the-impact-of-frailty-on-icu-and-30-day-mortality-and-the-level-of-care-in-very-elderly-patients-%C3%A2-%C3%A2-80%C3%A2-years
#1
Hans Flaatten, Dylan W De Lange, Alessandro Morandi, Finn H Andersen, Antonio Artigas, Guido Bertolini, Ariane Boumendil, Maurizio Cecconi, Steffen Christensen, Loredana Faraldi, Jesper Fjølner, Christian Jung, Brian Marsh, Rui Moreno, Sandra Oeyen, Christina Agwald Öhman, Bernardo Bollen Pinto, Ivo W Soliman, Wojciech Szczeklik, Andreas Valentin, Ximena Watson, Tilemachos Zaferidis, Bertrand Guidet
PURPOSE: Very old critical ill patients are a rapid expanding group in the ICU. Indications for admission, triage criteria and level of care are frequently discussed for such patients. However, most relevant outcome studies in this group frequently find an increased mortality and a reduced quality of life in survivors. The main objective was to study the impact of frailty compared with other variables with regards to short-term outcome in the very old ICU population. METHODS: A transnational prospective cohort study from October 2016 to May 2017 with 30 days follow-up was set up by the European Society of Intensive Care Medicine...
September 21, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28935666/non-occupational-exposure-to-asbestos-and-risk-of-pleural-mesothelioma-review-and-meta-analysis
#2
Gary M Marsh, Alexander S Riordan, Kara A Keeton, Stacey M Benson
OBJECTIVE: To conduct an updated literature review and meta-analysis of studies of pleural malignant mesothelioma (PMM) risk among persons exposed to asbestos non-occupationally (household and neighbourhood). METHODS: We performed a literature search for articles available in the National Center for Biotechnology Information's PubMed database published between 1967 and 2016. Meta-analyses were conducted to calculate pooled PMM risk estimates, stratifying for household or neighbourhood exposure to asbestos and/or predominant asbestos fibre type (chrysotile, amphibole or mixed)...
September 21, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28934597/the-recent-atlantic-cold-anomaly-causes-consequences-and-related-phenomena
#3
Simon A Josey, Joel J-M Hirschi, Bablu Sinha, Aurélie Duchez, Jeremy P Grist, Robert Marsh
Cold ocean temperature anomalies have been observed in the mid- to high-latitude North Atlantic on interannual to centennial timescales. Most notably, a large region of persistently low surface temperatures accompanied by a sharp reduction in ocean heat content was evident in the subpolar gyre from the winter of 2013-2014 to 2016, and the presence of this feature at a time of pervasive warming elsewhere has stimulated considerable debate. Here, we review the role of air-sea interaction and ocean processes in generating this cold anomaly and place it in a longer-term context...
September 15, 2017: Annual Review of Marine Science
https://www.readbyqxmd.com/read/28934428/hiv-infected-children-have-elevated-levels-of-pd-1-memory-cd4-t-cells-with-low-proliferative-capacity-and-high-inflammatory-cytokine-effector-functions
#4
Julia Foldi, Lina Kozhaya, Bret McCarty, Mussa Mwamzuka, Fatma Marshed, Tiina Ilmet, Max Kilberg, Adam Kravietz, Aabid Ahmed, William Borkowsky, Derya Unutmaz, Alka Khaitan
Background: During human immunodeficiency virus (HIV) disease, chronic immune activation leads to T-cell exhaustion. PD-1 identifies "exhausted" CD8 T cells with impaired HIV-specific effector functions, but its role on CD4 T cells and in HIV-infected children is poorly understood. Methods: In a Kenyan cohort of vertically HIV-infected children, we measured PD-1+ CD4 T-cell frequencies and phenotype by flow cytometry and their correlation with HIV disease progression and immune activation...
September 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28934362/evaluating-sampling-strategy-for-dna-barcoding-study-of-coastal-and-inland-halo-tolerant-poaceae-and-chenopodiaceae-a-case-study-for-increased-sample-size
#5
Peng-Cheng Yao, Hai-Yan Gao, Ya-Nan Wei, Jian-Hang Zhang, Xiao-Yong Chen, Hong-Qing Li
Environmental conditions in coastal salt marsh habitats have led to the development of specialist genetic adaptations. We evaluated six DNA barcode loci of the 53 species of Poaceae and 15 species of Chenopodiaceae from China's coastal salt marsh area and inland area. Our results indicate that the optimum DNA barcode was ITS for coastal salt-tolerant Poaceae and matK for the Chenopodiaceae. Sampling strategies for ten common species of Poaceae and Chenopodiaceae were analyzed according to optimum barcode. We found that by increasing the number of samples collected from the coastal salt marsh area on the basis of inland samples, the number of haplotypes of Arundinella hirta, Digitaria ciliaris, Eleusine indica, Imperata cylindrica, Setaria viridis, and Chenopodium glaucum increased, with a principal coordinate plot clearly showing increased distribution points...
2017: PloS One
https://www.readbyqxmd.com/read/28932860/immobilized-enzymes-understanding-enzyme-surface-interactions-at-the-molecular-level
#6
REVIEW
Marie Hoarau, Somayesadat Badieyan, E Neil G Marsh
Enzymes immobilized on solid supports have important and industrial and medical applications. However, their uses are limited by the significant reductions in activity and stability that often accompany the immobilization process. Here we review recent advances in our understanding of the molecular level interactions between proteins and supporting surfaces that contribute to changes in stability and activity. This understanding has been facilitated by the application of various surface-sensitive spectroscopic techniques that allow the structure and orientation of enzymes at the solid/liquid interface to be probed, often with monolayer sensitivity...
September 21, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28931842/restoring-tides-to-reduce-methane-emissions-in-impounded-wetlands-a-new-and-potent-blue-carbon-climate-change-intervention
#7
Kevin D Kroeger, Stephen Crooks, Serena Moseman-Valtierra, Jianwu Tang
Coastal wetlands are sites of rapid carbon (C) sequestration and contain large soil C stocks. Thus, there is increasing interest in those ecosystems as sites for anthropogenic greenhouse gas emission offset projects (sometimes referred to as "Blue Carbon"), through preservation of existing C stocks or creation of new wetlands to increase future sequestration. Here we show that in the globally-widespread occurrence of diked, impounded, drained and tidally-restricted salt marshes, substantial methane (CH4) and CO2 emission reductions can be achieved through restoration of disconnected saline tidal flows...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28931675/comparative-transcriptomics-highlights-the-role-of-the-ap1-transcription-factor-in-the-host-response-to-ebolavirus
#8
James W Wynne, Shawn Todd, Victoria Boyd, Mary Tachedjian, Reuben Klein, Brian Shiell, Megan Dearnley, Alexander J McAuley, Amanda P Woon, Anthony W Purcell, Glenn A Marsh, Michelle L Baker
Ebolavirus and Marburgvirus comprise two genera of negative-sense single-stranded RNA viruses that cause severe hemorrhagic fevers in humans. Despite considerable research efforts, the molecular events following Ebola virus (EBOV) infection are poorly understood. With the view of identifying host factors that underpin EBOV pathogenesis, we compared the transcriptomes of EBOV-infected human, pig and bat kidney cells using an RNAseq approach. Despite a significant difference in viral transcription/replication between the cell lines, all cells responded to EBOV infection through a robust induction of extracellular growth factors...
September 20, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28928719/the-green-berry-consortia-of-the-sippewissett-salt-marsh-millimeter-sized-aggregates-of-diazotrophic-unicellular-cyanobacteria
#9
Elizabeth G Wilbanks, Verena Salman-Carvalho, Ulrike Jaekel, Parris T Humphrey, Jonathan A Eisen, Daniel H Buckley, Stephen H Zinder
Microbial interactions driving key biogeochemical fluxes often occur within multispecies consortia that form spatially heterogeneous microenvironments. Here, we describe the "green berry" consortia of the Sippewissett salt marsh (Falmouth, MA, United States): millimeter-sized aggregates dominated by an uncultured, diazotrophic unicellular cyanobacterium of the order Chroococcales (termed GB-CYN1). We show that GB-CYN1 is closely related to Crocosphaera watsonii (UCYN-B) and "Candidatus Atelocyanobacterium thalassa" (UCYN-A), two groups of unicellular diazotrophic cyanobacteria that play an important role in marine primary production...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28928433/measuring-the-role-of-seagrasses-in-regulating-sediment-surface-elevation
#10
Maria Potouroglou, James C Bull, Ken W Krauss, Hilary A Kennedy, Marco Fusi, Daniele Daffonchio, Mwita M Mangora, Michael N Githaiga, Karen Diele, Mark Huxham
Seagrass meadows provide numerous ecosystem services and their rapid global loss may reduce human welfare as well as ecological integrity. In common with the other 'blue carbon' habitats (mangroves and tidal marshes) seagrasses are thought to provide coastal defence and encourage sediment stabilisation and surface elevation. A sophisticated understanding of sediment elevation dynamics in mangroves and tidal marshes has been gained by monitoring a wide range of different sites, located in varying hydrogeomorphological conditions over long periods...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28926020/animal-health-economics-an-aid-to-decisionmaking-on-animal-health-interventions-case-studies-in-the-united-states-of-america
#11
T L Marsh, D Pendell, R Knippenberg
For animal disease events the outcomes and consequences often remain unclear or uncertain, including the expected changes in benefits (e.g. profit to firms, prices to consumers) and in costs (e.g. response, clean-up). Moreover, the measurement of changes in benefits and costs across alternative interventions used to control animal disease events may be inexact. For instance, the economic consequences of alternative vaccination strategies to mitigate a disease can vary in magnitude due to trade embargoes and other factors...
April 2017: Revue Scientifique et Technique
https://www.readbyqxmd.com/read/28923731/phosphorus-sorption-desorption-and-effects-of-temperature-ph-and-salinity-on-phosphorus-sorption-in-marsh-soils-from-coastal-wetlands-with-different-flooding-conditions
#12
Junhong Bai, Xiaofei Ye, Jia Jia, Guangliang Zhang, Qingqing Zhao, Baoshan Cui, Xinhui Liu
Wetland soils act as a sink or source of phosphorus (P) to the overlaying water due to phosphorus sorption-desorption processes. Litter information is available on sorption and desorption behaviors of phosphorus in coastal wetlands with different flooding conditions. Laboratory experiments were conducted to investigate phosphorus sorption-desorption processes, fractions of adsorbed phosphorus, and the effects of salinity, pH and temperature on phosphorus sorption on soils in tidal-flooding wetlands (TW), freshwater-flooding wetlands (FW) and seasonal-flooding wetlands (SW) in the Yellow River Delta...
August 24, 2017: Chemosphere
https://www.readbyqxmd.com/read/28922261/the-effect-of-gluten-free-diet-on-clinical-symptoms-and-the-intestinal-mucosa-of-patients-with-potential-celiac-disease
#13
Roberta Mandile, Valentina Discepolo, Serena Scapaticci, Maria Rosaria Del Vecchio, Maria Antonia Maglio, Luigi Greco, Riccardo Troncone, Renata Auricchio
In this prospective study, we evaluated the effect of gluten free diet (GFD) in a cohort of 65 children with potential celiac disease (PCD). Patients received GFD for signs/symptoms (N = 47) or parents' choice (N = 18). Most frequent signs/symptoms were low Body Mass Index (BMI) (36%), recurrent abdominal pain (34%) and diarrhea (19%). Of the 35/47 patients followed-up on GFD, only 54% (19/35) showed a complete clinical response. In 9/65 patients an intestinal biopsy was also performed after at least one year of GFD...
September 16, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28917107/effects-of-coffee-processing-residues-on-anaerobic-microorganisms-and-corresponding-digestion-performance
#14
Juan Pablo Rojas-Sossa, Mariana Murillo-Roos, Lidieth Uribe, Lorena Uribe-Lorio, Terence Marsh, Niels Larsen, Rui Chen, Alberto Miranda, Kattia Solís, Werner Rodriguez, Dana Kirk, Wei Liao
The objective of this study was to delineate the effects of different coffee processing residues on the anaerobic microbes and corresponding digestion performance. The results elucidated that mucilage-rich feed enhanced the accumulation of methanogens, which consequently led to better digestion performance of biogas production. Fifty percent more methane and up to 3 times more net energy (heat and electricity) output were achieved by the digestion of the mucilage-rich feed (M3). The microbial community and statistical analyses further elucidated that different residues in the feed had significant impact on microbial distribution and correspondingly influenced the digestion performance...
August 19, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28912485/serial-millisecond-crystallography-for-routine-room-temperature-structure-determination-at-synchrotrons
#15
Tobias Weinert, Natacha Olieric, Robert Cheng, Steffen Brünle, Daniel James, Dmitry Ozerov, Dardan Gashi, Laura Vera, May Marsh, Kathrin Jaeger, Florian Dworkowski, Ezequiel Panepucci, Shibom Basu, Petr Skopintsev, Andrew S Doré, Tian Geng, Robert M Cooke, Mengning Liang, Andrea E Prota, Valerie Panneels, Przemyslaw Nogly, Ulrich Ermler, Gebhard Schertler, Michael Hennig, Michel O Steinmetz, Meitian Wang, Jörg Standfuss
Historically, room-temperature structure determination was succeeded by cryo-crystallography to mitigate radiation damage. Here, we demonstrate that serial millisecond crystallography at a synchrotron beamline equipped with high-viscosity injector and high frame-rate detector allows typical crystallographic experiments to be performed at room-temperature. Using a crystal scanning approach, we determine the high-resolution structure of the radiation sensitive molybdenum storage protein, demonstrate soaking of the drug colchicine into tubulin and native sulfur phasing of the human G protein-coupled adenosine receptor...
September 14, 2017: Nature Communications
https://www.readbyqxmd.com/read/28902904/assessing-coastal-wetland-vulnerability-to-sea-level-rise-along-the-northern-gulf-of-mexico-coast-gaps-and-opportunities-for-developing-a-coordinated-regional-sampling-network
#16
Michael J Osland, Kereen T Griffith, Jack C Larriviere, Laura C Feher, Donald R Cahoon, Nicholas M Enwright, David A Oster, John M Tirpak, Mark S Woodrey, Renee C Collini, Joseph J Baustian, Joshua L Breithaupt, Julia A Cherry, Jeremy R Conrad, Nicole Cormier, Carlos A Coronado-Molina, Joseph F Donoghue, Sean A Graham, Jennifer W Harper, Mark W Hester, Rebecca J Howard, Ken W Krauss, Daniel E Kroes, Robert R Lane, Karen L McKee, Irving A Mendelssohn, Beth A Middleton, Jena A Moon, Sarai C Piazza, Nicole M Rankin, Fred H Sklar, Greg D Steyer, Kathleen M Swanson, Christopher M Swarzenski, William C Vervaeke, Jonathan M Willis, K Van Wilson
Coastal wetland responses to sea-level rise are greatly influenced by biogeomorphic processes that affect wetland surface elevation. Small changes in elevation relative to sea level can lead to comparatively large changes in ecosystem structure, function, and stability. The surface elevation table-marker horizon (SET-MH) approach is being used globally to quantify the relative contributions of processes affecting wetland elevation change. Historically, SET-MH measurements have been obtained at local scales to address site-specific research questions...
2017: PloS One
https://www.readbyqxmd.com/read/28901010/habitat-use-of-the-european-mudminnow-umbra-krameri-and-association-with-other-fish-species-in-a-disconnected-danube-side-arm
#17
M Sehr, H Keckeis
Fish assemblages along the longitudinal course of an old, disconnected and modified side arm of the Danube floodplain downstream of Vienna, Austria, as well as habitat structure, hydro-morphological and hydro-chemical factors, were investigated in order to analyse the key environmental determinants of the European mudminnow Umbra krameri. Generally, U. krameri was the most abundant species in the system. It occurred in disconnected ditches, ponds and pools with dense reed belts and comparatively low nutrient content, indicating its natural association with marsh habitats...
September 12, 2017: Journal of Fish Biology
https://www.readbyqxmd.com/read/28898599/transcriptomic-basis-of-metamorphic-competence-in-the-salt-marsh-dwelling-polychaete-capitella-teleta
#18
Robert Burns, Jan Pechenik
Marine invertebrate larvae typically take hours to weeks after being released into the plankton before becoming "competent" to metamorphose. The mechanisms that govern this transition between the precompetent and metamorphically competent states are unknown. We studied gene expression patterns in precompetent and competent larvae of the salt-marsh-dwelling polychaete worm Capitella teleta (Blake, Grassle & Eckelbarger, 2009)-a species in which precompetent larvae are unusually easy to distinguish from competent larvae-to determine differences in gene expression associated with the onset of metamorphic competence...
June 2017: Biological Bulletin
https://www.readbyqxmd.com/read/28894523/correlation-between-cut-off-level-of-tissue-transglutaminase-antibody-and-marsh-classification
#19
Sumeet Kaur, Seema Gupta, Bela Goyal, Jasbinder Kaur
No abstract text is available yet for this article.
July 2017: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28893865/roc-king-onwards-intraepithelial-lymphocyte-counts-distribution-role-in-coeliac-disease-mucosal-interpretation
#20
Kamran Rostami, Michael N Marsh, Matt W Johnson, Hamid Mohaghegh, Calvin Heal, Geoffrey Holmes, Arzu Ensari, David Aldulaimi, Brigitte Bancel, Gabrio Bassotti, Adrian Bateman, Gabriel Becheanu, Anna Bozzola, Antonio Carroccio, Carlo Catassi, Carolina Ciacci, Alexandra Ciobanu, Mihai Danciu, Mohammad H Derakhshan, Luca Elli, Stefano Ferrero, Michelangelo Fiorentino, Marilena Fiorino, Azita Ganji, Kamran Ghaffarzadehgan, James J Going, Sauid Ishaq, Alessandra Mandolesi, Sherly Mathews, Roxana Maxim, Chris J Mulder, Andra Neefjes-Borst, Marie Robert, Ilaria Russo, Mohammad Rostami-Nejad, Angelo Sidoni, Masoud Sotoudeh, Vincenzo Villanacci, Umberto Volta, Mohammad R Zali, Amitabh Srivastava
OBJECTIVES: Counting intraepithelial lymphocytes (IEL) is central to the histological diagnosis of coeliac disease (CD), but no definitive 'normal' IEL range has ever been published. In this multicentre study, receiver operating characteristic (ROC) curve analysis was used to determine the optimal cut-off between normal and CD (Marsh III lesion) duodenal mucosa, based on IEL counts on >400 mucosal biopsy specimens. DESIGN: The study was designed at the International Meeting on Digestive Pathology, Bucharest 2015...
September 11, 2017: Gut
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