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https://www.readbyqxmd.com/read/29166355/restoring-faculty-vitality-in-academic-medicine-when-burnout-threatens
#1
Darshana T Shah, Valerie N Williams, Luanne E Thorndyke, E Eugene Marsh, Roberta E Sonnino, Steven M Block, Thomas R Viggiano
Increasing rates of burnout-with accompanying stress and lack of engagement-among faculty, residents, students, and practicing physicians have caused alarm in academic medicine. Central to the debate among academic medicine's stakeholders are oft-competing issues of social accountability; cost containment; effectiveness of academic medicine's institutions; faculty recruitment, retention, and satisfaction; increasing expectations for faculty; and mission-based productivity.The authors propose that understanding and fostering what contributes to faculty and institutional vitality is central to preventing burnout during times of change...
November 21, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29165924/the-emancipation-of-women-s-fertility
#2
EDITORIAL
Michael Marsh
No abstract text is available yet for this article.
December 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29165378/effects-of-sediment-chemical-properties-on-phosphorus-release-rates-in-the-sediment-water-interface-of-the-steppe-wetlands
#3
Jing He, Derong Su, Shihai Lv, Zhaoyan Diao, Jingjie Xie, Yan Luo
Rising temperature causes a process of phosphorus release, which can be characterized well using phosphorus release rates (VP). The objective of the present study was to investigate the major factors affecting sediment phosphorus release rates through a wetland habitat simulation experiment. The results showed that the VP of different wetland sediments were different and changed with the order of W-R (river wetland) > W-L (lake wetland) > W-M (grassy marsh wetland) > W-A (reservoir wetland). The main driving factors which influenced sediment phosphorus flux velocity in the sediment-water interface were sediment B-SO₄(2-), B-MBN and A-MBP content...
November 22, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29164264/risks-and-benefits-of-salpingectomy-at-the-time-of-sterilization
#4
Tara Castellano, Matthew Zerden, Laura Marsh, Kim Boggess
Importance: Bilateral salpingectomy reduces the risk ovarian cancer. The Society of Gynecologic Oncology has recommended surgeons discuss salpingectomy with patients desiring sterilization. Objective: This review summarizes current literature on the benefits and risks of bilateral salpingectomy to reduce ovarian cancer risk. Areas of insufficient evidence and directions for further research are discussed. Evidence Acquisition: We examined the benefits and risks of bilateral salpingectomy for female surgical sterilization, using a PubMed and EMBASE literature review...
November 2017: Obstetrical & Gynecological Survey
https://www.readbyqxmd.com/read/29163397/functionality-of-root-associated-bacteria-along-a-salt-marsh-primary-succession
#5
Miao Wang, Erqin Li, Chen Liu, Alexandre Jousset, Joana F Salles
Plant-associated bacteria are known for their high functional trait diversity, from which many are likely to play a role in primary and secondary succession, facilitating plant establishment in suboptimal soils conditions. Here we used an undisturbed salt marsh chronosequence that represents over 100 years of soil development to assess how the functional traits of plant associated bacteria respond to soil type, plant species and plant compartment. We isolated and characterized 808 bacterial colonies from the rhizosphere soil and root endosphere of two salt marsh plants, Limonium vulgare and Artemisia maritima, along the chronosequence...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29162692/phosphorylation-of-huntingtin-at-residue-t3-is-decreased-in-huntington-s-disease-and-modulates-mutant-huntingtin-protein-conformation
#6
Cristina Cariulo, Lucia Azzollini, Margherita Verani, Paola Martufi, Roberto Boggio, Anass Chiki, Sean M Deguire, Marta Cherubini, Silvia Gines, J Lawrence Marsh, Paola Conforti, Elena Cattaneo, Iolanda Santimone, Ferdinando Squitieri, Hilal A Lashuel, Lara Petricca, Andrea Caricasole
Posttranslational modifications can have profound effects on the biological and biophysical properties of proteins associated with misfolding and aggregation. However, their detection and quantification in clinical samples and an understanding of the mechanisms underlying the pathological properties of misfolding- and aggregation-prone proteins remain a challenge for diagnostics and therapeutics development. We have applied an ultrasensitive immunoassay platform to develop and validate a quantitative assay for detecting a posttranslational modification (phosphorylation at residue T3) of a protein associated with polyglutamine repeat expansion, namely Huntingtin, and characterized its presence in a variety of preclinical and clinical samples...
November 21, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29162098/malaria-early-warning-tool-linking-inter-annual-climate-and-malaria-variability-in-northern-guadalcanal-solomon-islands
#7
Jason Smith, Lloyd Tahani, Albino Bobogare, Hugo Bugoro, Francis Otto, George Fafale, David Hiriasa, Adna Kazazic, Grant Beard, Amanda Amjadali, Isabelle Jeanne
BACKGROUND: Malaria control remains a significant challenge in the Solomon Islands. Despite progress made by local malaria control agencies over the past decade, case rates remain high in some areas of the country. Studies from around the world have confirmed important links between climate and malaria transmission. This study focuses on understanding the links between malaria and climate in Guadalcanal, Solomon Islands, with a view towards developing a climate-based monitoring and early warning for periods of enhanced malaria transmission...
November 21, 2017: Malaria Journal
https://www.readbyqxmd.com/read/29159391/annals-for-hospitalists-inpatient-notes-the-other-catheter-the-mighty-peripheral-iv
#8
Claire M Rickard, Nicole M Marsh
No abstract text is available yet for this article.
November 21, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29158501/diverse-landscapes-beneath-pine-island-glacier-influence-ice-flow
#9
Robert G Bingham, David G Vaughan, Edward C King, Damon Davies, Stephen L Cornford, Andrew M Smith, Robert J Arthern, Alex M Brisbourne, Jan De Rydt, Alastair G C Graham, Matteo Spagnolo, Oliver J Marsh, David E Shean
The retreating Pine Island Glacier (PIG), West Antarctica, presently contributes ~5-10% of global sea-level rise. PIG's retreat rate has increased in recent decades with associated thinning migrating upstream into tributaries feeding the main glacier trunk. To project future change requires modelling that includes robust parameterisation of basal traction, the resistance to ice flow at the bed. However, most ice-sheet models estimate basal traction from satellite-derived surface velocity, without a priori knowledge of the key processes from which it is derived, namely friction at the ice-bed interface and form drag, and the resistance to ice flow that arises as ice deforms to negotiate bed topography...
November 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/29152928/nomenclature-for-factors-of-the-hla-system-update-august-2017
#10
S G E Marsh
No abstract text is available yet for this article.
December 2017: HLA
https://www.readbyqxmd.com/read/29152927/nomenclature-for-factors-of-the-hla-system-update-september-2017
#11
S G E Marsh
No abstract text is available yet for this article.
December 2017: HLA
https://www.readbyqxmd.com/read/29152926/nomenclature-for-factors-of-the-hla-system-update-july-2017
#12
S G E Marsh
No abstract text is available yet for this article.
December 2017: HLA
https://www.readbyqxmd.com/read/29151871/genetic-and-epigenetic-variation-in-spartina-alterniflora-following-the-deepwater-horizon-oil-spill
#13
Marta Robertson, Aaron Schrey, Ashley Shayter, Christina J Moss, Christina Richards
Catastrophic events offer unique opportunities to study rapid population response to stress in natural settings. In concert with genetic variation, epigenetic mechanisms may allow populations to persist through severe environmental challenges. In 2010, the Deepwater Horizon oil spill devastated large portions of the coastline along the Gulf of Mexico. However, the foundational salt marsh grass, Spartina alterniflora, showed high resilience to this strong environmental disturbance. Following the spill, we simultaneously examined the genetic and epigenetic structure of recovering populations of S...
September 2017: Evolutionary Applications
https://www.readbyqxmd.com/read/29150892/expanding-the-neurodevelopmental-phenotype-of-pura-syndrome
#14
Bo Hoon Lee, Margot R F Reijnders, Oluwatobi Abubakare, Emily Tuttle, Brynn Lape, Kelly Q Minks, Christopher Stodgell, Loisa Bennetto, Jennifer Kwon, Chin-To Fong, Karen W Gripp, Eric D Marsh, Wendy E Smith, Ahm M Huq, Stephanie A Coury, Wen-Hann Tan, Orestes Solis, Rupal I Mehta, Richard J Leventer, Diana Baralle, David Hunt, Alex R Paciorkowski
PURA syndrome is a recently described developmental encephalopathy presenting with neonatal hypotonia, feeding difficulties, global developmental delay, severe intellectual disability, and frequent apnea and epilepsy. We describe 18 new individuals with heterozygous sequence variations in PURA. A neuromotor disorder starting with neonatal hyptonia, but ultimately allowing delayed progression to walking, was present in nearly all individuals. Congenital apnea was present in 56% during infancy, but all cases in this cohort resolved during the first year of life...
November 17, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29150084/radiology-led-lung-escalation-pathway-a-streamlined-innovative-service-expediting-the-diagnosis-of-lung-cancer
#15
J Cox, J Spratt, A Ajith, S Haydar, G Gordon, S Elwell, R Marsh
No abstract text is available yet for this article.
November 14, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/29149581/family-matters-measuring-impact-through-one-s-academic-descendants
#16
Elizabeth J Marsh
Scientific contributions take many forms, not all of which result in fame or are captured in traditional metrics of success (e.g., h factor). My focus is on one of the most lasting and important contributions a scientist can make: training scientists who go on to train scientists, who in turn train more scientists, etc. Academic genealogies provide many examples of scientists whose names might not be recognizable today but who trained psychologists that went on to publish very influential work. Of course success results from a combination of many factors (including but not limited to the student's abilities and motivation, luck, institutional resources, mentoring, etc...
November 2017: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
https://www.readbyqxmd.com/read/29148122/altered-frontal-interhemispheric-and-fronto-limbic-structural-connectivity-in-unmedicated-adults-with-obsessive-compulsive-disorder
#17
Xiaofu He, Emily Steinberg, Mihaela Stefan, Martine Fontaine, H Blair Simpson, Rachel Marsh
BACKGROUND: Previous diffusion tensor imaging (DTI) studies of obsessive-compulsive disorder (OCD) have primarily used voxel- or tract-based methods to assess white matter microstructure in medicated patients. This is the first probabilistic tractography study to assess the structural connectivity of all major white matter tracts in unmedicated adults with OCD without comorbid psychopathology. We hypothesized that OCD compared to healthy participants would show reduced integrity in frontal interhemispheric and fronto-limbic tracts...
November 16, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/29144158/glycosylation-repurposes-alpha-1-antitrypsin-for-resolution-of-community-acquired-pneumonia
#18
Cormac McCarthy, Danielle M Dunlea, Radka Saldova, Michael Henry, Paula Meleady, Oliver J McElvaney, Brian Marsh, Pauline M Rudd, Emer P Reeves, Noel G McElvaney
No abstract text is available yet for this article.
November 16, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29143645/impact-of-heat-treatment-on-dirofilaria-immitis-antigen-detection-in-shelter-dogs
#19
Brian A DiGangi, Carly Dworkin, Jason W Stull, Jeanette O'Quin, Morgan Elser, Antoinette E Marsh, Lesli Groshong, Wendy Wolfson, Brandy Duhon, Katie Broaddus, Elise N Gingrich, Emily Swiniarski, Elizabeth A Berliner
BACKGROUND: The diagnosis and management of canine heartworm disease is a growing concern for shelter veterinarians. Although the accuracy of commercial antigen test kits has been widely studied, recent reports have renewed interest in antigen blocking as a causative factor for false "no antigen detected" results. The objectives of this study were to determine the prevalence of false "no antigen detected" results in adult dogs entering shelters in northern, southern, and western regions of the country and to identify historical and clinical risk factors for such results...
November 9, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29143475/amygdala-sub-regional-functional-connectivity-predicts-anxiety-in-children-with-reading-disorder
#20
Katie Davis, Amy E Margolis, Lauren Thomas, Zhiyong Huo, Rachel Marsh
Pediatric reading disorder (RD) is associated with an increased risk of anxiety symptoms, yet understudied are the neurobiological factors that might underlie anxiety in children with RD. Given the role of the amygdala in anxiety, we assessed resting state functional connectivity of amygdalar subregions in children with RD to identify functional correlates of anxiety and reading impairment. We collected resting state functional MRI data from 22 children with RD and 21 typically developing (TD) children, ages 7 to 13 years...
November 15, 2017: Developmental Science
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