Ana Sofía Ríos, Simón Oxenford, Clemens Neudorfer, Konstantin Butenko, Ningfei Li, Nanditha Rajamani, Alexandre Boutet, Gavin J B Elias, Jurgen Germann, Aaron Loh, Wissam Deeb, Fuyixue Wang, Kawin Setsompop, Bryan Salvato, Leonardo Brito de Almeida, Kelly D Foote, Robert Amaral, Paul B Rosenberg, David F Tang-Wai, David A Wolk, Anna D Burke, Stephen Salloway, Marwan N Sabbagh, M Mallar Chakravarty, Gwenn S Smith, Constantine G Lyketsos, Michael S Okun, William S Anderson, Zoltan Mari, Francisco A Ponce, Andres M Lozano, Andreas Horn
Deep brain stimulation (DBS) to the fornix is an investigational treatment for patients with mild Alzheimer's Disease. Outcomes from randomized clinical trials have shown that cognitive function improved in some patients but deteriorated in others. This could be explained by variance in electrode placement leading to differential engagement of neural circuits. To investigate this, we performed a post-hoc analysis on a multi-center cohort of 46 patients with DBS to the fornix (NCT00658125, NCT01608061). Using normative structural and functional connectivity data, we found that stimulation of the circuit of Papez and stria terminalis robustly associated with cognitive improvement (R = 0...
December 14, 2022: Nature Communications