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Deep Brain Stimulation Alzheimer's

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https://www.readbyqxmd.com/read/27920671/proceedings-of-the-fourth-annual-deep-brain-stimulation-think-tank-a-review-of-emerging-issues-and-technologies
#1
Wissam Deeb, James J Giordano, Peter J Rossi, Alon Y Mogilner, Aysegul Gunduz, Jack W Judy, Bryan T Klassen, Christopher R Butson, Craig Van Horne, Damiaan Deny, Darin D Dougherty, David Rowell, Greg A Gerhardt, Gwenn S Smith, Francisco A Ponce, Harrison C Walker, Helen M Bronte-Stewart, Helen S Mayberg, Howard J Chizeck, Jean-Philippe Langevin, Jens Volkmann, Jill L Ostrem, Jonathan B Shute, Joohi Jimenez-Shahed, Kelly D Foote, Aparna Wagle Shukla, Marvin A Rossi, Michael Oh, Michael Pourfar, Paul B Rosenberg, Peter A Silburn, Coralie de Hemptine, Philip A Starr, Timothy Denison, Umer Akbar, Warren M Grill, Michael S Okun
This paper provides an overview of current progress in the technological advances and the use of deep brain stimulation (DBS) to treat neurological and neuropsychiatric disorders, as presented by participants of the Fourth Annual DBS Think Tank, which was convened in March 2016 in conjunction with the Center for Movement Disorders and Neurorestoration at the University of Florida, Gainesveille FL, USA. The Think Tank discussions first focused on policy and advocacy in DBS research and clinical practice, formation of registries, and issues involving the use of DBS in the treatment of Tourette Syndrome...
2016: Frontiers in Integrative Neuroscience
https://www.readbyqxmd.com/read/27758681/deep-brain-stimulation-for-alzheimer-s-disease
#2
David S Xu, Francisco Ponce
High-frequency deep brain stimulation (DBS) is a neurosurgical procedure that was introduced in the late 1980s for the treatment of movement disorders. It is a reversible, adjustable, and non-ablative therapy that has been used in over 100,000 people worldwide. The surgical procedure used to implant the DBS system, as well as the effects of chronic electrical stimulation, have been shown to be safe and effective through many clinical trials. The ability to therapeutically modulate the motor circuits of the brain in this manner has resulted in consideration of use of this surgical strategy for other neurodegenerative and neuropsychiatric disorders involving non-motor circuits, including appetite, mood, and cognition...
October 14, 2016: Current Alzheimer Research
https://www.readbyqxmd.com/read/27567879/brain-stimulation-in-alzheimer-s-disease
#3
Itzhak Fried
Deep brain stimulation has been successfully used in treatment of motor symptoms of Parkinson's disease and other movement disorders. In a recent multi-center prospectively randomized study, deep brain stimulation of the fornix was administered in order to ameliorate the cognitive symptoms and clinical course of Alzheimer's disease (AD). The study points to the possibility of modest slowing of the cognitive decline in AD in a subset of patients older than 65, while at the same time highlights the risk of stimulation in exacerbation of this decline in younger patients...
September 6, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27567810/a-phase-ii-study-of-fornix-deep-brain-stimulation-in-mild-alzheimer-s-disease
#4
Andres M Lozano, Lisa Fosdick, M Mallar Chakravarty, Jeannie-Marie Leoutsakos, Cynthia Munro, Esther Oh, Kristen E Drake, Christopher H Lyman, Paul B Rosenberg, William S Anderson, David F Tang-Wai, Jo Cara Pendergrass, Stephen Salloway, Wael F Asaad, Francisco A Ponce, Anna Burke, Marwan Sabbagh, David A Wolk, Gordon Baltuch, Michael S Okun, Kelly D Foote, Mary Pat McAndrews, Peter Giacobbe, Steven D Targum, Constantine G Lyketsos, Gwenn S Smith
BACKGROUND: Deep brain stimulation (DBS) is used to modulate the activity of dysfunctional brain circuits. The safety and efficacy of DBS in dementia is unknown. OBJECTIVE: To assess DBS of memory circuits as a treatment for patients with mild Alzheimer's disease (AD). METHODS: We evaluated active "on" versus sham "off" bilateral DBS directed at the fornix-a major fiber bundle in the brain's memory circuit-in a randomized, double-blind trial (ClinicalTrials...
September 6, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27539594/tau-amyloid-beta-and-deep-brain-stimulation-aiming-to-restore-cognitive-deficit-in-alzheimer-s-disease
#5
Siddhartha Mondragón-Rodríguez, George Perry, Fernando Peña-Ortega, Sylvain Williams
The last two decades have seen a great advance in the data that supports the two current hypotheses in Alzheimer's disease (AD) field, the amyloid beta (Aβ) hypothesis and the tau hypothesis. Not surprisingly, Aβ and tau proteins are currently the major therapeutic research targets for AD treatment. Unfortunately, nothing but moderate success has emerged from such therapeutic approaches. With this in mind, we will discuss deep brain stimulation (DBS) as a promising therapeutic strategy that aims to restore brain activity...
August 19, 2016: Current Alzheimer Research
https://www.readbyqxmd.com/read/27536216/effects-of-long-term-environmental-enrichment-on-anxiety-memory-hippocampal-plasticity-and-overall-brain-gene-expression-in-c57bl6-mice
#6
Melanie Hüttenrauch, Gabriela Salinas, Oliver Wirths
There is ample evidence that physical activity exerts positive effects on a variety of brain functions by facilitating neuroprotective processes and influencing neuroplasticity. Accordingly, numerous studies have shown that continuous exercise can successfully diminish or prevent the pathology of neurodegenerative diseases such as Alzheimer's disease in transgenic mouse models. However, the long-term effect of physical activity on brain health of aging wild-type (WT) mice has not yet been studied in detail...
2016: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/27399357/deep-brain-stimulation-targets-technology-and-trials-two-decades-of-progress
#7
Kim J Burchiel
AD, Alzheimer diseaseDBS, Deep brain stimulationFDA, Food and Drug AdministrationMER, Microelectrode recording.
August 2016: Neurosurgery
https://www.readbyqxmd.com/read/27399356/deep-brain-stimulation-of-the-fornix-engaging-therapeutic-circuits-and-networks-in-alzheimer-disease
#8
Nathan C Rowland, Francesco Sammartino, Jennifer C Tomaszczyk, Andres M Lozano
No abstract text is available yet for this article.
August 2016: Neurosurgery
https://www.readbyqxmd.com/read/27330836/linear-and-curvilinear-trajectories-of-cortical-loss-with-advancing-age-and-disease-duration-in-parkinson-s-disease
#9
Daniel O Claassen, David G Dobolyi, David A Isaacs, Olivia C Roman, Joshua Herb, Scott A Wylie, Joseph S Neimat, Manus J Donahue, Peter Hedera, David H Zald, Bennett A Landman, Aaron B Bowman, Benoit M Dawant, Swati Rane
Advancing age and disease duration both contribute to cortical thinning in Parkinson's disease (PD), but the pathological interactions between them are poorly described. This study aims to distinguish patterns of cortical decline determined by advancing age and disease duration in PD. A convenience cohort of 177 consecutive PD patients, identified at the Vanderbilt University Movement Disorders Clinic as part of a clinical evaluation for Deep Brain Stimulation (age: M= 62.0, SD 9.3), completed a standardized clinical assessment, along with structural brain Magnetic Resonance Imaging scan...
May 2016: Aging and Disease
https://www.readbyqxmd.com/read/27132526/neuromodulation-for-restoring-memory
#10
Sarah K B Bick, Emad N Eskandar
Disorders of learning and memory have a large social and economic impact in today's society. Unfortunately, existing medical treatments have shown limited clinical efficacy or potential for modification of the disease course. Deep brain stimulation is a successful treatment for movement disorders and has shown promise in a variety of other diseases including psychiatric disorders. The authors review the potential of neuromodulation for the treatment of disorders of learning and memory. They briefly discuss learning circuitry and its involvement in Alzheimer disease and traumatic brain injury...
May 2016: Neurosurgical Focus
https://www.readbyqxmd.com/read/26892497/transient-micro-needle-insertion-into-hippocampus-triggers-neurogenesis-and-decreases-amyloid-burden-in-a-mouse-model-of-alzheimer-s-disease
#11
Shijie Song, Xiaoyung Kong, Vasyl Sava, Chuanhai Cao, Sandra Acosta, Cesar Borlongan, Juan Sanchez-Ramos
Targeted micro-lesions of the hippocampus have been reported to enhance neurogenesis in the sub-granular zone (SGZ). The potential therapeutic impact of transient insertion of a micro-needle was investigated in a mouse model of Alzheimer's disease (AD). Here we tested the hypothesis that transient micro-injury to the brain elicits cellular responses that mediate beneficial regenerative processes. Brief stereotaxic insertion and removal of a micro-needle into the right hippocampus of 14 month old APP/PS1 mice brain resulted in a) stimulation of hippocampal neurogenesis and b) reduction of beta-amyloid plaque number in the CA-1 region...
February 18, 2016: Cell Transplantation
https://www.readbyqxmd.com/read/26780572/fornix-deep-brain-stimulation-circuit-effect-is-dependent-on-major-excitatory-transmission-via-the-nucleus-accumbens
#12
Erika K Ross, Joo Pyung Kim, Megan L Settell, Seong Rok Han, Charles D Blaha, Hoon-Ki Min, Kendall H Lee
INTRODUCTION: Deep brain stimulation (DBS) is a circuit-based treatment shown to relieve symptoms from multiple neurologic and neuropsychiatric disorders. In order to treat the memory deficit associated with Alzheimer's disease (AD), several clinical trials have tested the efficacy of DBS near the fornix. Early results from these studies indicated that patients who received fornix DBS experienced an improvement in memory and quality of life, yet the mechanisms behind this effect remain controversial...
March 2016: NeuroImage
https://www.readbyqxmd.com/read/26701378/neurologist-ambulatory-care-health-care-utilization-and-costs-in-a-large-commercial-dataset
#13
John P Ney, Barbara Johnson, Tom Knabel, Karolina Craft, Joel Kaufman
OBJECTIVE: To determine the value of neurologist ambulatory care in chronic neurologic diseases in a large administrative claims dataset detailing costs, adverse events, and health care utilization. METHODS: The Optum proprietary claims dataset (2010-2012) was examined to describe direct health care costs, as well as specific outcome metrics for a large population of persons with chronic neurologic illnesses. In phase I of the study, we detail neurologist involvement and differences in annualized allowed third--party payments within episode treatment groups (ETGs) for 10 neurologic illnesses...
January 26, 2016: Neurology
https://www.readbyqxmd.com/read/26684775/bilateral-deep-brain-stimulation-of-the-fornix-for-alzheimer-s-disease-surgical-safety-in-the-advance-trial
#14
Francisco A Ponce, Wael F Asaad, Kelly D Foote, William S Anderson, G Rees Cosgrove, Gordon H Baltuch, Kara Beasley, Donald E Reymers, Esther S Oh, Steven D Targum, Gwenn S Smith, Constantine G Lyketsos, Andres M Lozano
OBJECT This report describes the stereotactic technique, hospitalization, and 90-day perioperative safety of bilateral deep brain stimulation (DBS) of the fornix in patients who underwent DBS for the treatment of mild, probable Alzheimer's disease (AD). METHODS The ADvance Trial is a multicenter, 12-month, double-blind, randomized, controlled feasibility study being conducted to evaluate the safety, efficacy, and tolerability of DBS of the fornix in patients with mild, probable AD. Intraoperative and perioperative data were collected prospectively...
July 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/26551238/neuroethical-implications-of-deep-brain-stimulation-in-degenerative-disorders
#15
REVIEW
Daniela Ovadia, Gabriella Bottini
PURPOSE OF REVIEW: The use of deep brain stimulation (DBS) in degenerative diseases involving cognitive impairment raises important ethical issues. This review takes into account the previous publications on the ethical issues of DBS to re-evaluate this technique in the framework of cognitive degenerative diseases, especially Alzheimer's disease and dementia associated to Parkinson's disease. RECENT FINDINGS: The serendipitous discovery of the properties of DBS in memory enhancement fostered the expectations of the patients, the experts, and the industry involved in the production of the devices...
December 2015: Current Opinion in Neurology
https://www.readbyqxmd.com/read/26469053/forniceal-deep-brain-stimulation-rescues-hippocampal-memory-in-rett-syndrome-mice
#16
Shuang Hao, Bin Tang, Zhenyu Wu, Kerstin Ure, Yaling Sun, Huifang Tao, Yan Gao, Akash J Patel, Daniel J Curry, Rodney C Samaco, Huda Y Zoghbi, Jianrong Tang
Deep brain stimulation (DBS) has improved the prospects for many individuals with diseases affecting motor control, and recently it has shown promise for improving cognitive function as well. Several studies in individuals with Alzheimer disease and in amnesic rats have demonstrated that DBS targeted to the fimbria-fornix, the region that appears to regulate hippocampal activity, can mitigate defects in hippocampus-dependent memory. Despite these promising results, DBS has not been tested for its ability to improve cognition in any childhood intellectual disability disorder...
October 15, 2015: Nature
https://www.readbyqxmd.com/read/26443701/the-rationale-for-deep-brain-stimulation-in-alzheimer-s-disease
#17
REVIEW
Zaman Mirzadeh, Ausaf Bari, Andres M Lozano
Alzheimer's disease is a major worldwide health problem with no effective therapy. Deep brain stimulation (DBS) has emerged as a useful therapy for certain movement disorders and is increasingly being investigated for treatment of other neural circuit disorders. Here we review the rationale for investigating DBS as a therapy for Alzheimer's disease. Phase I clinical trials of DBS targeting memory circuits in Alzheimer's disease patients have shown promising results in clinical assessments of cognitive function, neurophysiological tests of cortical glucose metabolism, and neuroanatomical volumetric measurements showing reduced rates of atrophy...
July 2016: Journal of Neural Transmission
https://www.readbyqxmd.com/read/26412285/changes-in-nutritional-status-after-deep-brain-stimulation-of-the-nucleus-basalis-of-meynert-in-alzheimer-s-disease-results-of-a-phase-i-study
#18
M Noreik, J Kuhn, K Hardenacke, D Lenartz, A Bauer, C P Bührle, P Häussermann, M Hellmich, J Klosterkötter, J Wiltfang, M Maarouf, H-J Freund, V Visser-Vandewalle, V Sturm, R-J Schulz
OBJECTIVE: The progression of Alzheimer's disease (AD) is associated with impaired nutritional status. New methods, such as deep brain stimulation (DBS), are currently being tested to decrease the progression of AD. DBS is an approved method in the treatment of Parkinson's disease, and its suitability for the treatment of AD patients is currently under experimental investigation. To evaluate the advantages and disadvantages of this new treatment, it is important to assess potential side effects of DBS regarding the nucleus basalis of Meynert; this new treatment is thought to positively affect cognition and might counteract the deterioration of nutritional status and progressive weight loss observed in AD...
October 2015: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/26321354/rapid-modulation-of-protein-expression-in-the-rat-hippocampus-following-deep-brain-stimulation-of-the-fornix
#19
Elise Gondard, Hien N Chau, Amandeep Mann, Travis S Tierney, Clement Hamani, Suneil K Kalia, Andres M Lozano
BACKGROUND: The forniceal area is currently being evaluated as a target for deep brain stimulation (DBS) to improve cognitive function in patients with Alzheimer's disease. The molecular changes at downstream targets within the stimulated circuit are unknown. OBJECTIVE: To analyze the modulation of hippocampal protein expression following 1 h of fornix DBS in the rat. METHODS: Animals underwent bilateral forniceal DBS for 1 h and sacrificed at different time-points after the initiation of the stimulation (1 h, 2...
November 2015: Brain Stimulation
https://www.readbyqxmd.com/read/26180683/deep-brain-stimulation-for-obesity
#20
REVIEW
Allen L Ho, Eric S Sussman, Michael Zhang, Arjun V Pendharkar, Dan E Azagury, Cara Bohon, Casey H Halpern
Obesity is now the third leading cause of preventable death in the US, accounting for 216,000 deaths annually and nearly 100 billion dollars in health care costs. Despite advancements in bariatric surgery, substantial weight regain and recurrence of the associated metabolic syndrome still occurs in almost 20-35% of patients over the long-term, necessitating the development of novel therapies. Our continually expanding knowledge of the neuroanatomic and neuropsychiatric underpinnings of obesity has led to increased interest in neuromodulation as a new treatment for obesity refractory to current medical, behavioral, and surgical therapies...
March 2015: Curēus
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