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Deep Brain Stimulation Alzheimer's

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https://www.readbyqxmd.com/read/29124106/gamma-rhythm-low-field-magnetic-stimulation-alleviates-neuropathologic-changes-and-rescues-memory-and-cognitive-impairments-in-a-mouse-model-of-alzheimer-s-disease
#1
Junli Zhen, Yanjing Qian, Xiechuan Weng, Wenting Su, Jianliang Zhang, Lihui Cai, Lin Dong, Haiting An, Ruijun Su, Jiang Wang, Yan Zheng, Xiaomin Wang
Introduction: The abnormal amyloid β (Aβ) accumulation and Aβ-related neural network dysfunction are considered central to the pathogenesis of Alzheimer's disease (AD) at the early stage. Deep-brain reachable low field magnetic stimulation (DMS), a novel noninvasive approach that was designed to intervene the network activity in brains, has been found to alleviate stress-related cognitive impairments. Methods: Amyloid precursor protein/presenilin-1 transgenic mice (5XFAD) were treated with DMS, and cognitive behavior and AD-like pathologic changes in the neurochemical and electrophysiological properties in 5XFAD mice were assessed...
November 2017: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://www.readbyqxmd.com/read/29072895/low-frequency-pulsed-electromagnetic-field-is-able-to-modulate-mirnas-in-an-experimental-cell-model-of-alzheimer-s-disease
#2
Enrica Capelli, Filippo Torrisi, Letizia Venturini, Maria Granato, Lorenzo Fassina, Giuseppe Francesco Damiano Lupo, Giovanni Ricevuti
The aim of the present study was to investigate on the effects of a low-frequency pulsed electromagnetic field (LF-PEMF) in an experimental cell model of Alzheimer's disease (AD) to assess new therapies that counteract neurodegeneration. In recent scientific literature, it is documented that the deep brain stimulation via electromagnetic fields (EMFs) modulates the neurophysiological activity of the pathological circuits and produces clinical benefits in AD patients. EMFs are applied for tissue regeneration because of their ability to stimulate cell proliferation and immune functions via the HSP70 protein family...
2017: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29065581/low-frequency-pulsed-electromagnetic-field-is-able-to-modulate-mirnas-in-an-experimental-cell-model-of-alzheimer-s-disease
#3
Enrica Capelli, Filippo Torrisi, Letizia Venturini, Maria Granato, Lorenzo Fassina, Giuseppe Francesco Damiano Lupo, Giovanni Ricevuti
The aim of the present study was to investigate on the effects of a low-frequency pulsed electromagnetic field (LF-PEMF) in an experimental cell model of Alzheimer's disease (AD) to assess new therapies that counteract neurodegeneration. In recent scientific literature, it is documented that the deep brain stimulation via electromagnetic fields (EMFs) modulates the neurophysiological activity of the pathological circuits and produces clinical benefits in AD patients. EMFs are applied for tissue regeneration because of their ability to stimulate cell proliferation and immune functions via the HSP70 protein family...
2017: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29055119/deep-brain-stimulation-of-the-nucleus-basalis-of-meynert-attenuates-early-eeg-components-associated-with-defective-sensory-gating-in-patients-with-alzheimer-disease-a-two-case-study
#4
Stefan Dürschmid, Christoph Reichert, Jens Kuhn, Hans-Joachim Freund, Hermann Hinrichs, Hans-Jochen Heinze
Alzheimer's disease (AD) is associated with deterioration of memory and cognitive function and a degeneration of neurons of the nucleus basalis of Meynert (NBM). The NBM is the major input source of Acetylcholine (ACh) to the cortex. The decreasing cholinergic innervation of the cortex due to degeneration of the NBM might be the cause of loss of memory function. NBM-Deep Brain Stimulation (NBM-DBS) is considered to serve as a potential therapeutic option for AD patients by supporting residual cholinergic transmission to stabilize oscillatory activity in memory relevant circuits...
October 20, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28927833/modulation-of-hippocampal-activity-with-fornix-deep-brain-stimulation
#5
Paul H Stypulkowski, Scott R Stanslaski, Jonathon E Giftakis
BACKGROUND: Deep Brain Stimulation (DBS) within the Papez circuit is under investigation as a treatment for epilepsy and Alzheimer's disease. We previously reported the effects of stimulation at nodes within this network (anterior thalamic nucleus and hippocampus) on hippocampal activity in a large animal model, using a chronic implantable, clinical-grade system that permits concurrent stimulation and recording. OBJECTIVE: In this study we extended earlier work to compare the effects of fornix DBS on evoked potentials (EPs) and local field potential (LFP) activity within the hippocampus, and to assess closed-loop stimulation...
September 6, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28713248/deep-brain-magnetic-stimulation-promotes-neurogenesis-and-restores-cholinergic-activity-in-a-transgenic-mouse-model-of-alzheimer-s-disease
#6
Junli Zhen, Yanjing Qian, Jian Fu, Ruijun Su, Haiting An, Wei Wang, Yan Zheng, Xiaomin Wang
Alzheimer's disease (AD) is characterized by progressive decline of memory and cognitive functions. Deep magnetic stimulation (DMS), a noninvasive and nonpharmacological brain stimulation, has been reported to alleviate stress-related cognitive impairment in neuropsychiatric disorders. Our previous study also discovered the preventive effect of DMS on cognitive decline in an AD mouse model. However, the underlying mechanism must be explored further. In this study, we investigated the effect of DMS on spatial learning and memory functions, neurogenesis in the dentate gyrus (DG), as well as expression and activity of the cholinergic system in a transgenic mouse model of AD (5XFAD)...
2017: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/28696431/synaptic-activity-protects-against-ad-and-ftd-like-pathology-via-autophagic-lysosomal-degradation
#7
Y Akwa, E Gondard, A Mann, E Capetillo-Zarate, E Alberdi, C Matute, S Marty, T Vaccari, A M Lozano, E E Baulieu, D Tampellini
Changes in synaptic excitability and reduced brain metabolism are among the earliest detectable alterations associated with the development of Alzheimer's disease (AD). Stimulation of synaptic activity has been shown to be protective in models of AD beta-amyloidosis. Remarkably, deep brain stimulation (DBS) provides beneficial effects in AD patients, and represents an important therapeutic approach against AD and other forms of dementia. While several studies have explored the effect of synaptic activation on beta-amyloid, little is known about Tau protein...
July 11, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28653404/neuroanatomical-characteristics-associated-with-response-to-deep-brain-stimulation-of-the-nucleus-basalis-of-meynert-for-alzheimer-s-disease
#8
Juan Carlos Baldermann, Katja Hardenacke, Xiaochen Hu, Phillip Köster, Andreas Horn, Hans-Joachim Freund, Karl Zilles, Volker Sturm, Veerle Visser-Vandewalle, Frank Jessen, David Maintz, Jens Kuhn
OBJECTIVES: First reports on the application of deep brain stimulation (DBS) of the Nucleus basalis of Meynert (NBM) showed feasibility and safety of the intervention in patients with Alzheimer´s disease. However, clinical effects vary and the mechanisms of actions are still not well understood. The aim of this study was to characterize neuroimaging changes that are associated with the responsiveness to the treatment. MATERIALS AND METHODS: We examined preoperative T1-weighted MR images of ten patients with Alzheimer's disease (AD) treated with DBS of the NBM and correlated the clinical outcome with volumetric differences of cortical thickness...
June 27, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28540926/entorhinal-cortical-deep-brain-stimulation-rescues-memory-deficits-in-both-young-and-old-mice-genetically-engineered-to-model-alzheimer-s-disease
#9
Frances Xia, Adelaide Yiu, Scellig S D Stone, Soojin Oh, Andres M Lozano, Sheena A Josselyn, Paul W Frankland
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive cognitive decline. Deep brain stimulation (DBS) has been used to treat a variety of brain disorders and shows promise in alleviating cognitive symptoms in some AD patients (Laxton et al, 2010). We previously showed that DBS of the entorhinal cortex (EC) enhances spatial memory formation in normal (wild-type) mice (Stone et al, 2011). Here we tested the effects of EC-DBS on the progressive cognitive deficits in a genetically-based mouse model of AD...
December 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28436389/ethical-considerations-for-deep-brain-stimulation-trials-in-patients-with-early-onset-alzheimer-s-disease
#10
John Noel M Viaña, Merlin Bittlinger, Frederic Gilbert
Several studies of deep brain stimulation (DBS) of the fornix or the nucleus basalis of Meynert have been recently conducted in people with Alzheimer's disease, with several recruiting participants <65 and thus have early-onset Alzheimer's disease (EOAD). Although EOAD accounts for less than 5.5% of AD cases, ethical considerations must still be made when performing DBS trials including these participants since a portion of people with EOAD, especially those possessing autosomal-dominant mutations, have an atypical and more aggressive disease progression...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28385550/currents-of-memory-recent-progress-translational-challenges-and-ethical-considerations-in-fornix-deep-brain-stimulation-trials-for-alzheimer-s-disease
#11
REVIEW
John Noel M Viaña, James C Vickers, Mark J Cook, Frederic Gilbert
The serendipitous discovery of triggered autobiographical memories and eventual memory improvement in an obese patient who received fornix deep brain stimulation in 2008 paved the way for several phase I and phase II clinical trials focused on the safety and efficacy of this potential intervention for people with Alzheimer's disease. In this article, we summarize clinical trials and case reports on fornix deep brain stimulation for Alzheimer's disease and review experiments on animal models evaluating the physiological or behavioral effects of this intervention...
March 11, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28304293/coordinate-based-meta-analysis-of-the-default-mode-and-salience-network-for-target-identification-in-non-invasive-brain-stimulation-of-alzheimer-s-disease-and-behavioral-variant-frontotemporal-dementia-networks
#12
Michela Pievani, Lorenzo Pini, Clarissa Ferrari, Francesca B Pizzini, Ilaria Boscolo Galazzo, Chiara Cobelli, Maria Cotelli, Rosa Manenti, Giovanni B Frisoni
BACKGROUND: The accurate choice of the site of non-invasive brain stimulation (NIBS) is an important factor in trial design. OBJECTIVE: Based on the observation that Alzheimer's disease (AD) and behavioral frontotemporal dementia (bvFTD) affect specific large-scale networks, i.e., the default mode network (DMN) and the salience network (SN), respectively, we aimed to identify population-average coordinates of these networks that could be used as potential targets in NIBS trials aiming to modulate these circuits...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28175430/deep-brain-stimulation-of-the-fornix-engaging-therapeutic-circuits-and-networks-in-alzheimer-disease
#13
Nathan C Rowland, Francesco Sammartino, Jennifer C Tomaszczyk, Andres M Lozano
No abstract text is available yet for this article.
August 1, 2016: Neurosurgery
https://www.readbyqxmd.com/read/27983548/deep-brain-stimulation-for-alzheimer-s-disease-ethical-challenges-for-clinical-research
#14
Andrew M Siegel, Marna S Barrett, Mahendra T Bhati
Deep brain stimulation (DBS) is an invasive neuromodulation modality that has shown early promise as a novel treatment of Alzheimer's disease (AD). Further clinical research is warranted on the basis of positive results from animal and human studies, as well as the inadequacy of existing treatments in reducing the enormous medical and financial costs of untreated AD. Nevertheless, unique ethical challenges require particular attention to elements of subject enrollment and informed consent. Study protocols should specify robust assessment and regular monitoring of subject decision-making capacity to consent to trial participation...
December 9, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27920671/proceedings-of-the-fourth-annual-deep-brain-stimulation-think-tank-a-review-of-emerging-issues-and-technologies
#15
Wissam Deeb, James J Giordano, Peter J Rossi, Alon Y Mogilner, Aysegul Gunduz, Jack W Judy, Bryan T Klassen, Christopher R Butson, Craig Van Horne, Damiaan Deny, Darin D Dougherty, David Rowell, Greg A Gerhardt, Gwenn S Smith, Francisco A Ponce, Harrison C Walker, Helen M Bronte-Stewart, Helen S Mayberg, Howard J Chizeck, Jean-Philippe Langevin, Jens Volkmann, Jill L Ostrem, Jonathan B Shute, Joohi Jimenez-Shahed, Kelly D Foote, Aparna Wagle Shukla, Marvin A Rossi, Michael Oh, Michael Pourfar, Paul B Rosenberg, Peter A Silburn, Coralie de Hemptine, Philip A Starr, Timothy Denison, Umer Akbar, Warren M Grill, Michael S Okun
This paper provides an overview of current progress in the technological advances and the use of deep brain stimulation (DBS) to treat neurological and neuropsychiatric disorders, as presented by participants of the Fourth Annual DBS Think Tank, which was convened in March 2016 in conjunction with the Center for Movement Disorders and Neurorestoration at the University of Florida, Gainesveille FL, USA. The Think Tank discussions first focused on policy and advocacy in DBS research and clinical practice, formation of registries, and issues involving the use of DBS in the treatment of Tourette Syndrome...
2016: Frontiers in Integrative Neuroscience
https://www.readbyqxmd.com/read/27758681/deep-brain-stimulation-for-alzheimer-s-disease
#16
REVIEW
David S Xu, Francisco A Ponce
High-frequency deep brain stimulation (DBS) was introduced in the late 1980s for the treatment of movement disorders. This reversible, adjustable, and non-ablative therapy has been used to treat more than 100,000 people worldwide. The surgical procedure used to implant the DBS system, as well as the effects of chronic electrical stimulation, have been shown to be safe and effective through many clinical trials. Given the ability to therapeutically modulate the motor circuits of the brain in this manner, clinicians have considered using DBS for other neurodegenerative and neuropsychiatric disorders involving non-motor circuits, including appetite, mood, and cognition...
2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/27567879/brain-stimulation-in-alzheimer-s-disease
#17
Itzhak Fried
Deep brain stimulation has been successfully used in treatment of motor symptoms of Parkinson's disease and other movement disorders. In a recent multi-center prospectively randomized study, deep brain stimulation of the fornix was administered in order to ameliorate the cognitive symptoms and clinical course of Alzheimer's disease (AD). The study points to the possibility of modest slowing of the cognitive decline in AD in a subset of patients older than 65, while at the same time highlights the risk of stimulation in exacerbation of this decline in younger patients...
September 6, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27567810/a-phase-ii-study-of-fornix-deep-brain-stimulation-in-mild-alzheimer-s-disease
#18
Andres M Lozano, Lisa Fosdick, M Mallar Chakravarty, Jeannie-Marie Leoutsakos, Cynthia Munro, Esther Oh, Kristen E Drake, Christopher H Lyman, Paul B Rosenberg, William S Anderson, David F Tang-Wai, Jo Cara Pendergrass, Stephen Salloway, Wael F Asaad, Francisco A Ponce, Anna Burke, Marwan Sabbagh, David A Wolk, Gordon Baltuch, Michael S Okun, Kelly D Foote, Mary Pat McAndrews, Peter Giacobbe, Steven D Targum, Constantine G Lyketsos, Gwenn S Smith
BACKGROUND: Deep brain stimulation (DBS) is used to modulate the activity of dysfunctional brain circuits. The safety and efficacy of DBS in dementia is unknown. OBJECTIVE: To assess DBS of memory circuits as a treatment for patients with mild Alzheimer's disease (AD). METHODS: We evaluated active "on" versus sham "off" bilateral DBS directed at the fornix-a major fiber bundle in the brain's memory circuit-in a randomized, double-blind trial (ClinicalTrials...
September 6, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27539594/tau-amyloid-beta-and-deep-brain-stimulation-aiming-to-restore-cognitive-deficit-in-alzheimer-s-disease
#19
REVIEW
Siddhartha Mondragón-Rodríguez, George Perry, Fernando Pena-Ortega, Sylvain Williams
BACKGROUND: The last two decades have seen a great advance in the data that supports the two current hypotheses in Alzheimer`s disease field, the amyloid beta hypothesis and the tau hypothesis. Not surprisingly, Aβ and tau proteins are currently the major therapeutic research targets for AD treatment. Unfortunately, nothing but moderate success has emerged from such therapeutic approaches. With this in mind, we will discuss deep brain stimulation as a promising therapeutic strategy that aims to restore brain activity...
2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/27536216/effects-of-long-term-environmental-enrichment-on-anxiety-memory-hippocampal-plasticity-and-overall-brain-gene-expression-in-c57bl6-mice
#20
Melanie Hüttenrauch, Gabriela Salinas, Oliver Wirths
There is ample evidence that physical activity exerts positive effects on a variety of brain functions by facilitating neuroprotective processes and influencing neuroplasticity. Accordingly, numerous studies have shown that continuous exercise can successfully diminish or prevent the pathology of neurodegenerative diseases such as Alzheimer's disease in transgenic mouse models. However, the long-term effect of physical activity on brain health of aging wild-type (WT) mice has not yet been studied in detail...
2016: Frontiers in Molecular Neuroscience
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