Jia Wang, Xiang Zheng, Zailong Qin, Lingyu Wei, Yuanjun Lu, Qiu Peng, Yingxue Gao, Xuemei Zhang, Xiaoyue Zhang, Zhengshuo Li, Yuxin Fu, Peishan Liu, Can Liu, Qun Yan, Wei Xiong, Guiyuan Li, Jianhong Lu, Jian Ma
Epstein-Barr virus-associated gastric cancer (EBVaGC) accounts for about 10% of all gastric cancer cases and has unique pathological and molecular characteristics. EBV encodes a large number of microRNAs, which actively participate in the development of EBV-related tumors. Here, we report that EBV-miR-BART3-3p (BART3-3p) promotes gastric cancer cell growth in vitro and in vivo Moreover, BART3-3p inhibits the senescence of gastric cancer cells induced by an oncogene (RASG12V ) or chemotherapy (irinotecan). LMP1 and EBNA3C encoded by EBV have also been reported to have antisenescence effects; however, in EBVaGC specimens, LMP1 expression is very low, and EBNA3C is not expressed...
March 29, 2019: Journal of Biological Chemistry