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https://www.readbyqxmd.com/read/28611866/association-of-cognitive-impairment-in-patients-on-3-hydroxy-3-methyl-glutaryl-coa-reductase-inhibitors
#1
Satyajeet Roy, Joshua Louis Weinstock, Allyse Sachiko Ishino, Jefferson Felix Benites, Samantha Rachel Pop, Christopher David Perez, Edvard Adrian Gumbs, Jennifer Ann Rosenbaum, Mary Kate Roccato, Hely Shah, Gabriela Contino, Krystal Hunter
BACKGROUND: Atherosclerotic cardiovascular diseases are the leading cause of death in the United States. A reduction in cholesterol with 3-hydroxy-3-methyl-glutaryl-CoA reductase inhibitors (statin) significantly reduces mortality and morbidity. Statins may be associated with cognitive impairment or dementia. Our aim was to study the association of cognitive impairment or dementia in patients who were on a statin. METHODS: Electronic medical records of 3,500 adult patients in our suburban internal medicine office were reviewed...
July 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28580392/a-genome-wide-association-study-meta-analysis-of-clinical-fracture-in-10-012-african-american-women
#2
Kira C Taylor, Daniel S Evans, Digna R Velez Edwards, Todd L Edwards, Tamar Sofer, Guo Li, Youfang Liu, Nora Franceschini, Rebecca D Jackson, Ayush Giri, Macarius Donneyong, Bruce Psaty, Jerome I Rotter, Andrea Z LaCroix, Joanne M Jordan, John A Robbins, Beth Lewis, Marcia L Stefanick, Yongmei Liu, Melissa Garcia, Tamara Harris, Jane A Cauley, Kari E North
BACKGROUND: Osteoporosis is a major public health problem associated with excess disability and mortality. It is estimated that 50-70% of the variation in osteoporotic fracture risk is attributable to genetic factors. The purpose of this hypothesis-generating study was to identify possible genetic determinants of fracture among African American (AA) women in a GWAS meta-analysis. METHODS: Data on clinical fractures (all fractures except fingers, toes, face, skull or sternum) were analyzed among AA female participants in the Women's Health Initiative (WHI) (N = 8155), Cardiovascular Health Study (CHS) (N = 504), BioVU (N = 704), Health ABC (N = 651), and the Johnston County Osteoarthritis Project (JoCoOA) (N = 291)...
December 2016: Bone Reports
https://www.readbyqxmd.com/read/28526253/racial-ethnic-differences-in-sleep-quality-among-older-adults-with-osteoarthritis
#3
Patricia A Parmelee, Brian S Cox, Jason A DeCaro, Francis J Keefe, Dylan M Smith
OBJECTIVE: To examine racial/ethnic differences in sleep quality and the pain-sleep association among older adults with osteoarthritis of the knee. DESIGN: Baseline interview followed by a 7-day microlongitudinal study using accelerometry and self-reports. SETTING: Participants were community residents in western Alabama and Long Island, NY. PARTICIPANTS: Ninety-six African Americans (AAs) and 128 non-Hispanic whites (NHWs) with physician-diagnosed knee osteoarthritis, recruited from a variety of clinical and community settings...
June 2017: Sleep Health
https://www.readbyqxmd.com/read/28447235/prevalence-of-musculoskeletal-diseases-in-a-semi-urban-nigerian-community-results-of-a-cross-sectional-survey-using-copcord-methodology
#4
Uhunmwangho U Courage, Dungwom P Stephen, Imoh C Lucius, Charles Ani, Agbaji O Oche, Agaba I Emmanuel, Adelowo O Olufemi
The International League of Associations for Rheumatology (ILAR) in collaboration with the World Health Organization (WHO) initiated the Community Oriented Program for the Control of Rheumatic diseases (COPCORD) to promote the growth of rheumatology in developing countries. This is the first COPCORD-type survey carried out in a West African community. The objective of this study was to determine the prevalence of musculoskeletal diseases in a semi-urban Nigerian community, using the COPCORD methodology. This is a cross-sectional total population survey, carried out in Katon Rikkos, Jos, Nigeria, from June 2015 to November 2016...
April 26, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28202744/a-cross-sectional-analysis-of-radiographic-ankle-osteoarthritis-frequency-and-associated-factors-the-johnston-county-osteoarthritis-project
#5
Shahmeer Lateef, Yvonne M Golightly, Jordan B Renner, Joanne M Jordan, Amanda E Nelson
OBJECTIVE: Because there are no epidemiologic data regarding the frequency of ankle osteoarthritis (OA) in a general population, we sought to analyze this disabling condition in a large, well-characterized, community-based cohort of older individuals. METHODS: Cross-sectional data, including ankle radiographs, were from the most recent data collection (2013-2015) of the Johnston County OA Project. Radiographic ankle OA (rAOA) was defined as a Kellgren-Lawrence arthritis grading scale of ≥ 2 on weight-bearing lateral and mortise radiographs...
April 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28143550/spectrum-of-paediatric-rheumatic-diseases-in-nigeria
#6
Babatunde Hakeem Olaosebikan, Olufemi Oladipo Adelowo, Barakat Adeola Animashaun, Richard Oluyinka Akintayo
BACKGROUND: Paediatric rheumatology service in Sub-Sahara African is virtually not available as there is a shortage of paediatric rheumatologists and other rheumatology health professionals. We aim to describe the clinical spectrum and the frequencies of paediatric rheumatic diseases (PRDs) in Lagos State University Teaching Hospital (LASUTH), Lagos, Nigeria. METHODS: This is a retrospective review of patients with PRDs seen over a five year period (March 2010 to February 2016) at the rheumatology clinic and children ward of LASUTH...
January 31, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/28123909/skeletal-pathology-and-variable-anatomy-in-elephant-feet-assessed-using-computed-tomography
#7
Sophie Regnault, Jonathon J I Dixon, Chris Warren-Smith, John R Hutchinson, Renate Weller
Foot problems are a major cause of morbidity and mortality in elephants, but are underreported due to difficulties in diagnosis, particularly of conditions affecting the bones and internal structures. Here we evaluate post-mortem computer tomographic (CT) scans of 52 feet from 21 elephants (seven African Loxodonta africana and 14 Asian Elephas maximus), describing both pathology and variant anatomy (including the appearance of phalangeal and sesamoid bones) that could be mistaken for disease. We found all the elephants in our study to have pathology of some type in at least one foot...
2017: PeerJ
https://www.readbyqxmd.com/read/27914722/poor-expectations-of-knee-replacement-benefit-are-associated-with-modifiable-psychological-factors-and-influence-the-decision-to-have-surgery-a-cross-sectional-and-longitudinal-study-of-a-community-based-sample
#8
Daniel L Riddle, Gregory J Golladay, Amanda Hayes, Hassan M K Ghomrawi
BACKGROUND: Total knee arthroplasty (TKA) is a highly effective surgery, but is underutilized by some patient groups. This study determined factors associated with a person's expectations with respect to pain and walking function following a TKA procedure, should they elect to undergo a TKA. METHODS: A total of 3542 people were studied with or at risk of knee osteoarthritis and enrolled in the community-based Osteoarthritis Initiative (OAI). Multivariable logistic regression analyses identified demographic, socioeconomic, osteoarthritis-related, joint replacement awareness, and psychological correlates as poor outcome expectations...
March 2017: Knee
https://www.readbyqxmd.com/read/27898457/ethnicity-cortisol-and-experimental-pain-responses-among-persons-with-symptomatic-knee-osteoarthritis
#9
Matthew S Herbert, Burel R Goodin, Hailey W Bulls, Adriana Sotolongo, Megan E Petrov, Jeffrey C Edberg, Laurence A Bradley, Roger B Fillingim
OBJECTIVES: While several factors are known to contribute to ethnic differences in pain, relatively little attention has been devoted to physiological factors. Our first aim was to examine the relationship between cortisol and pain responses during a cold-pressor task (CPT) among African American (AA) and non-Hispanic White (NHW) adults with knee osteoarthritis (OA). Our second aim was to assess the relationship between perceived racial discrimination and cortisol among AA participants...
November 28, 2016: Clinical Journal of Pain
https://www.readbyqxmd.com/read/27776013/chronic-health-conditions-in-medicare-beneficiaries-65-years-and-older-with-hiv-infection
#10
Eleanor E Friedman, Wayne A Duffus
OBJECTIVES: To examine sociodemographic factors and chronic health conditions of people living with HIV (PLWHIV/HIV+) at least 65 years old and compare their chronic disease prevalence with beneficiaries without HIV. DESIGN: National fee-for-service Medicare claims data (parts A and B) from 2006 to 2009 were used to create a retrospective cohort of beneficiaries at least 65 years old. METHODS: Beneficiaries with an inpatient or skilled nursing facility claim, or outpatient claims with HIV diagnosis codes were considered HIV+...
October 23, 2016: AIDS
https://www.readbyqxmd.com/read/27575040/calcaneocuboid-joint-arthritis-of-the-midfoot-precedes-tibiotalar-joint-arthritis
#11
Anthony Dugarte, Sahil Bharwani, HoJun Yoo, Alexander Vondra Boiwka, Charles C Yu, Navkirat S Bajwa, Jason O Toy, Jonathan E Tang, Uri Ahn, Nicholas Ahn
Surgical models have best shown the relationship between ankle and mid-foot osteoarthritis, although findings regarding the calcaneocuboid joint have varied. To the authors' knowledge, no studies have evaluated the relationship between degenerative changes across the tibiotalar and calcaneocuboid joints. The goal of this study was to determine whether such a relationship exists and which joint degenerates first. A single examiner evaluated 694 tibiotalar and calcaneocuboid joints to determine the presence of osteoarthritis...
November 1, 2016: Orthopedics
https://www.readbyqxmd.com/read/27553385/pain-coping-skills-training-for-african-americans-with-osteoarthritis-staart-study-protocol-of-a-randomized-controlled-trial
#12
Leah A Schrubbe, Scott G Ravyts, Bernadette C Benas, Lisa C Campbell, Crystal W Cené, Cynthia J Coffman, Alexander H Gunn, Francis J Keefe, Caroline T Nagle, Eugene Z Oddone, Tamara J Somers, Catherine L Stanwyck, Shannon S Taylor, Kelli D Allen
BACKGROUND: African Americans bear a disproportionate burden of osteoarthritis (OA), with higher prevalence rates, more severe pain, and more functional limitations. One key barrier to addressing these disparities has been limited engagement of African Americans in the development and evaluation of behavioral interventions for management of OA. Pain Coping Skills Training (CST) is a cognitive-behavioral intervention with shown efficacy to improve OA-related pain and other outcomes. Emerging data indicate pain CST may be a promising intervention for reducing racial disparities in OA symptom severity...
August 23, 2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27478988/chronic-health-conditions-in-medicare-beneficiaries-65-years-old-and-older-with-hiv-infection
#13
Eleanor E Friedman, Wayne A Duffus
OBJECTIVES: To examine sociodemographic factors and chronic health conditions of people living with HIV (PLWHIV/HIV+) at least 65 years old and compare their chronic disease prevalence with beneficiaries without HIV. DESIGN: National fee-for-service Medicare claims data (parts A and B) from 2006 to 2009 were used to create a retrospective cohort of beneficiaries at least 65 years old. METHODS: Beneficiaries with an inpatient or skilled nursing facility claim, or outpatient claims with HIV diagnosis codes were considered HIV+...
October 23, 2016: AIDS
https://www.readbyqxmd.com/read/27343253/establishment-of-reference-intervals-for-osteoarthritis-related-soluble-biomarkers-the-fnih-oarsi-oa-biomarkers-consortium
#14
Virginia B Kraus, David E Hargrove, David J Hunter, Jordan B Renner, Joanne M Jordan
OBJECTIVE: To establish reference intervals for osteoarthritis (OA)-related biomarkers used in the Foundation for the National Institutes of Health (FNIH) OA Biomarkers Consortium Project. METHODS: A total of 129 'multijoint controls' were selected from 2722 African-American and Caucasian men and women in the Johnston County Osteoarthritis Project. The majority (79%) of those eligible (with biospecimens and baseline data) also had one or more follow-up evaluations 5-15 years later...
January 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27233479/significant-improvements-in-pain-after-a-six-week-physiotherapist-led-exercise-and-education-intervention-in-patients-with-osteoarthritis-awaiting-arthroplasty-in-south-africa-a-randomised-controlled-trial
#15
M M Saw, T Kruger-Jakins, N Edries, R Parker
BACKGROUND: A major challenge facing those with late stage osteoarthritis is delayed surgery due to waiting lists. In South Africa patients wait years for a hip/knee arthroplasty. Affected patients require effective management to address their pain, especially while awaiting surgery. Existing literature is mostly available from high income countries exploring effects of interventions during short waiting periods. Research is warranted in low income countries where long waiting periods are common...
May 27, 2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27109873/annual-incidence-rates-of-hip-symptoms-and-three-hip-oa-outcomes-from-a-u-s-population-based-cohort-study-the-johnston-county-osteoarthritis-project
#16
A S Moss, L B Murphy, C G Helmick, T A Schwartz, K E Barbour, J B Renner, W Kalsbeek, J M Jordan
OBJECTIVE: Estimate annual incidence rates (IRs) of hip symptoms and three osteoarthritis (OA) outcomes (radiographic, symptomatic, and severe radiographic) overall and by race, sociodemographic characteristics, and hip OA risk factors. DESIGN: Analyze baseline (1991-1997) and first follow-up (1999-2003) data (n = 1446) from the Johnston County Osteoarthritis Project, a population-based, prospective study of adults ≥45 years in North Carolina. Hip symptoms were pain, aching, and/or stiffness on most days, or groin pain...
September 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27075333/does-a-patient-centered-educational-intervention-affect-african-american-access-to-knee-replacement-a-randomized-trial
#17
RANDOMIZED CONTROLLED TRIAL
Ernest R Vina, Diane Richardson, Elina Medvedeva, C Kent Kwoh, Aliya Collier, Said A Ibrahim
BACKGROUND: A TKA is the most effective and cost-effective surgical option for moderate to severe osteoarthritis (OA) of the knee. Yet, black patients are less willing to undergo knee replacement surgery than white patients. Decision aids help people understand treatment options and consider the personal importance of possible benefits and harms of treatments, including TKA. QUESTIONS/PURPOSES: We asked: (1) Does a patient-centered intervention consisting of a decision aid for knee OA and motivational interviewing improve the proportion of referrals of blacks with knee OA to orthopaedic surgery? (2) Does the intervention increase patients' willingness to undergo TKA? METHODS: Adults who self-identified as black who were at least 50 years old with moderate to severe knee OA were enrolled from urban primary care clinics in a two-group randomized, controlled trial...
August 2016: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/27052590/factors-associated-with-disability-among-middle-aged-and-older-african-american-women-with-osteoarthritis
#18
Janiece L Walker, Tracie C Harrison, Adama Brown, Roland J Thorpe, Sarah L Szanton
BACKGROUND: Middle-aged and older African American women experience disproportionate rates of functional limitations and disability from osteoarthritis (OA) compared to other racial ethnic groups; however, little is known about what factors contribute to this disparity within African American women. OBJECTIVE: To examine factors associated with physical function and disability among African American women ages 50-80 with OA using the disablement process model. METHODS: This descriptive study included 120 African American women with OA from the Southwestern region of the United States...
July 2016: Disability and Health Journal
https://www.readbyqxmd.com/read/27014966/number-of-persons-with-symptomatic-knee-osteoarthritis-in-the-us-impact-of-race-and-ethnicity-age-sex-and-obesity
#19
Bhushan R Deshpande, Jeffrey N Katz, Daniel H Solomon, Edward H Yelin, David J Hunter, Stephen P Messier, Lisa G Suter, Elena Losina
OBJECTIVE: The prevalence of symptomatic knee osteoarthritis (OA) has been increasing over the past several decades in the US, concurrent with an aging population and the growing obesity epidemic. We quantify the impact of these factors on the number of persons with symptomatic knee OA in the early decades of the 21st century. METHODS: We calculated the prevalence of clinically diagnosed symptomatic knee OA from the National Health Interview Survey 2007-2008 and derived the proportion with advanced disease (defined as Kellgren/Lawrence grade 3 or 4) using the Osteoarthritis Policy Model, a validated simulation model of knee OA...
December 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27011947/the-association-of-serum-25-hydroxyvitamin-d-status-in-patients-with-osteoarthritis-in-the-primary-care-office
#20
Celine Ward, Krysta Contino, Akshar Patel, Eben Eno Mbei, Satyajeet Roy, Krystal Hunter, Shivani Gandhi
BACKGROUND: Low serum 25-hydroxyvitamin D [25(OH)D] and osteoarthritis (OA) are commonly found in patients followed up in a primary care office. Clear evidence to support the link between 25-hydroxyvitamin D levels and OA is lacking. AIM: To describe the association of serum 25-hydroxyvitamin D status in patients with OA in the primary care office. MATERIALS AND METHODS: We reviewed the records of 1,455 patients seen in our primary care office between November 2013 and October 2014...
January 2016: North American Journal of Medical Sciences
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