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Polyautoimmunity

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https://www.readbyqxmd.com/read/28457757/juvenile-myasthenia-gravis-in-norway-clinical-characteristics-treatment-and-long-term-outcome-in-a-nationwide-population-based-cohort
#1
T H Popperud, M I Boldingh, M Rasmussen, E Kerty
BACKGROUND: This study aimed to characterize juvenile myasthenia gravis in a national population-based cohort in Norway, and to evaluate long-term outcome and potential differences correlated with prepubertal versus postpubertal disease onset. PATIENTS AND METHODS: Patients with onset of myasthenia gravis aged ≤18 years were identified through multiple strategies. Retrospective clinical data were collected by means of medical charts. All patients had an updated clinical examination...
April 20, 2017: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/28457101/autoimmune-tautology-in-a-complex-case-of-polyautoimmunity-systemic-sclerosis-autoimmune-liver-involvement-antiphospholipid-syndrome-and-hashimoto-s-thyroiditis
#2
Francesca Wanda Rossi, Antonio Lobasso, Carmine Selleri, Marco Matucci-Cerinic, Felice Rivellese, Yehuda Shoenfeld, Amato de Paulis
No abstract text is available yet for this article.
March 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28393451/similarities-and-differences-between-older-and-young-adult-patients-with-celiac-disease
#3
Çağdaş Kalkan, Fatih Karakaya, Irfan Soykan
AIM: Celiac disease is an autoimmune enteropathy with variable clinical symptoms. Elderly patients can have different manifestations from those of young patients. The aims of the present study were to investigate whether any differences or similarities exist between older and young patients with celiac disease with a special emphasis on concurrent autoimmune diseases. METHODS: Celiac disease patients were stratified as older and younger patients. These two groups were then compared by means of clinical symptoms, laboratory parameters and concurrent autoimmune diseases...
April 10, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28216074/autoimmunity-in-guillain-barr%C3%A3-syndrome-associated-with-zika-virus-infection-and-beyond
#4
REVIEW
Carlos A Pinto-Díaz, Yhojan Rodríguez, Diana M Monsalve, Yeny Acosta-Ampudia, Nicolás Molano-González, Juan-Manuel Anaya, Carolina Ramírez-Santana
Autoimmune diseases share common immunopathogenic mechanisms (i.e., the autoimmune tautology), which explain the clinical similarities among them as well as their familial clustering. Guillain-Barré syndrome (GBS), an autoimmune peripheral neuropathy, has been recently associated with Zika virus (ZIKV) infection. Based on a series of cases, this review article provides a comparative analysis of GBS associated with ZIKV infection, contrasted with the general characteristics of GBS in light of the autoimmune tautology, including gender differences in prevalence, subphenotypes, polyautoimmunity, familial autoimmunity, age at onset, pathophysiology, ecology, genetics, ancestry, and treatment...
April 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/27906873/polyautoimmunity-a%C3%A2-significant-issue-in%C3%A2-connective-tissue-diseases
#5
EDITORIAL
Marzena Olesińska, Katarzyna Romanowska-Próchnicka
No abstract text is available yet for this article.
November 28, 2016: Polskie Archiwum Medycyny Wewnętrznej
https://www.readbyqxmd.com/read/27476624/familial-autoimmunity-and-polyautoimmunity-in-60-brazilian-midwest-patients-with-systemic-sclerosis
#6
Alex Magno Coelho Horimoto, Aida Freitas do Carmo Silveira, Izaias Pereira da Costa
INTRODUCTION: Systemic sclerosis (SSc) is a connective tissue disease of unknown etiology, characterized by a triad of vascular injury, autoimmunity and tissue fibrosis. It is known that a positive family history is the greatest risk factor already identified for the development of SSc in a given individual. Preliminary observation of a high prevalence of polyautoimmunity and of familial autoimmunity in SSc patients support the idea that different autoimmune phenotypes may share common susceptibility variants...
July 2016: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/27444719/differences-between-older-and-young-patients-with-autoimmune-gastritis
#7
Çağdaş Kalkan, Irfan Soykan
AIM: Elderly patients with autoimmune gastritis might have different symptoms than those of young patients. The aim of the present study was to compare presented symptoms and laboratory parameters associated with autoimmune gastritis in both old and young age groups. METHODS: A total of 355 patients with autoimmune gastritis were stratified into two groups: 65 years or older (n = 119, mean age 69.47 ± 5.027 years), and under 65 years (n = 236, mean age 45...
July 22, 2016: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/27431348/polyautoimmunity-in-sj%C3%A3-gren-syndrome
#8
REVIEW
Juan-Manuel Anaya, Adriana Rojas-Villarraga, Ruben D Mantilla, Mauricio Arcos-Burgos, Juan Camilo Sarmiento-Monroy
Polyautoimmunity is defined as the presence of more than one well-defined autoimmune disease (AD) in a single patient. Polyautoimmunity is a frequent condition in Sjögren syndrome (SS) and follows a grouping pattern. The most frequent ADs observed in SS are autoimmune thyroid disease, rheumatoid arthritis, and systemic lupus erythematosus. Main factors associated with polyautoimmunity in SS are tobacco smoking and some genetic variants. The study of polyautoimmunity provides important clues for elucidating the common mechanisms of autoimmne diseases (ie, the autoimmune tautology)...
August 2016: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/27209085/definition-of-mutations-in-polyautoimmunity
#9
Angad Johar, Juan C Sarmiento-Monroy, Adriana Rojas-Villarraga, Maria F Silva-Lara, Hardip R Patel, Ruben D Mantilla, Jorge I Velez, Klaus-Martin Schulte, Claudio Mastronardi, Mauricio Arcos-Burgos, Juan-Manuel Anaya
OBJECTIVES: Familial autoimmunity and polyautoimmunity represent extreme phenotypes ideal for identifying major genomic variants contributing to autoimmunity. Whole exome sequencing (WES) and linkage analysis are well suited for this purpose due to its strong resolution upon familial segregation patterns of functional protein coding and splice variants. The primary objective of this study was to identify potentially autoimmune causative variants using WES data from extreme pedigrees segregating polyautoimmunity phenotypes...
August 2016: Journal of Autoimmunity
https://www.readbyqxmd.com/read/27085391/polyautoimmunity-in-autoimmune-gastritis
#10
Çağdaş Kalkan, Irfan Soykan
OBJECTIVES: Autoimmune gastritis may be associated with other organ-specific autoimmune disorders, but the prevalence of this association is not entirely quantified. The aims of this study were to investigate the prevalence of autoimmune disorders and evaluate the factors that might affect this association in patients with autoimmune gastritis. METHODS: A total of 320 patients with autoimmune gastritis were retrospectively studied and data on concomitant autoimmune diseases, serum gastrin and chromogranin A levels, anti-Hp IgG, antiparietal cell antibodies, presence of enterochromaffin-like cell hyperplasia and gastric atrophy were gathered for each patient and associations between autoimmune gastritis and studied parameters were explored through descriptive statistics and logistic regression analysis...
June 2016: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/27057999/lrba-deficiency-with-autoimmunity-and-early-onset-chronic-erosive-polyarthritis
#11
Eva Lévy, Marie-Claude Stolzenberg, Julie Bruneau, Sylvain Breton, Bénédicte Neven, Sylvie Sauvion, Mohammed Zarhrate, Patrick Nitschké, Alain Fischer, Aude Magérus-Chatinet, Pierre Quartier, Frédéric Rieux-Laucat
LRBA (lipopolysaccharide-responsive and beige-like anchor protein) deficiency associates immune deficiency, lymphoproliferation, and various organ-specific autoimmunity. To date, prevalent symptoms are autoimmune cytopenias and enteropathy, and lymphocytic interstitial lung disease. In 2 siblings from a consanguineous family presenting with early onset polyautoimmunity, we presumed autosomal recessive inheritance and performed whole exome sequencing. We herein report the first case of early-onset, severe, chronic polyarthritis associated with LRBA deficiency...
July 2016: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/26809482/familial-autoimmunity-and-polyautoimmunity-in-60-brazilian-midwest-patients-with-systemic-sclerosis
#12
Alex Magno Coelho Horimoto, Aida Freitas do Carmo Silveira, Izaias Pereira da Costa
INTRODUCTION: Systemic sclerosis (SSc) is a connective tissue disease of unknown etiology, characterized by a triad of vascular injury, autoimmunity and tissue fibrosis. It is known that a positive family history is the greatest risk factor already identified for the development of SSc in a given individual. Preliminary observation of a high prevalence of poliautoimmunity and of familial autoimmunity in SSc patients support the idea that different autoimmune phenotypes may share common susceptibility variants...
January 13, 2016: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/26697508/familial-aggregation-and-segregation-analysis-in-families-presenting-autoimmunity-polyautoimmunity-and-multiple-autoimmune-syndrome
#13
John Castiblanco, Juan Camilo Sarmiento-Monroy, Ruben Dario Mantilla, Adriana Rojas-Villarraga, Juan-Manuel Anaya
Studies documenting increased risk of developing autoimmune diseases (ADs) have shown that these conditions share several immunogenetic mechanisms (i.e., the autoimmune tautology). This report explored familial aggregation and segregation of AD, polyautoimmunity, and multiple autoimmune syndrome (MAS) in 210 families. Familial aggregation was examined for first-degree relatives. Segregation analysis was implemented as in S.A.G.E. release 6.3. Data showed differences between late- and early-onset families regarding their age, age of onset, and sex...
2015: Journal of Immunology Research
https://www.readbyqxmd.com/read/26376434/risk-factors-for-polyautoimmunity-among-patients-with-celiac-disease-a-cross-sectional-survey
#14
Aylin Demirezer Bolat, Fatma Ebru Akın, Mustafa Tahtacı, Öykü Tayfur Yürekli, Hüseyin Köseoğlu, Şükran Erten, Murat Başaran, Eyüp Selvi, Şemnur Büyükaşık, Osman Ersoy
AIM: To define the prevalence of polyautoimmunity (PAI) among celiac disease (CD) patients and to compare clinical and laboratory features of CD patients with or without PAI in order to determine the risk factors for PAI in CD. MATERIAL AND METHOD: Patients diagnosed with CD in our clinic between 2007 and 2014 with at least 1 year of follow-up were retrospectively evaluated. Totally 145 patients were included in the study. Information on patient demographics and laboratory data were obtained from patient records...
2015: Digestion
https://www.readbyqxmd.com/read/25427993/autoimmune-thyroid-disease-and-rheumatoid-arthritis-relationship-and-the-role-of-genetics
#15
REVIEW
Ivica Lazúrová, Ivana Jochmanová, Karim Benhatchi, Stefan Sotak
Autoimmune thyroid disease (AITD), known as the most common organ-specific autoimmune disorder, is frequently accompanied by other organ and non-organ-specific autoimmune diseases, including rheumatoid arthritis (RA). Although the exact pathogenic mechanisms of the coexistence of autoimmune disorders are still not completely defined, genetics, immune defects, hormones and environmental factors may play key roles in polyautoimmunity. In this review, the prevalence of AITD and antithyroid autoantibodies in RA patients and rheumatic manifestations in association with thyroid autoimmunity are discussed...
December 2014: Immunologic Research
https://www.readbyqxmd.com/read/25382266/autoimmune-thyroid-disease-in-colombian-patients-with-systemic-lupus-erythematosus
#16
Juan-Sebastian Franco, Jenny Amaya-Amaya, Nicolás Molano-González, Julian Caro-Moreno, Mónica Rodríguez-Jiménez, Yeny Acosta-Ampudia, Rubén D Mantilla, Adriana Rojas-Villarraga, Juan-Manuel Anaya
OBJECTIVES: To determine the prevalence and the predictive factors of autoimmune hypothyroidism (AH) within a systemic lupus erythematosus (SLE) cohort and to analyse the current information concerning the prevalence and impact of autoimmune thyroid disease (AITD) and thyroid autoimmunity in patients with SLE. METHODS: A total of 376 patients with SLE were assessed for the presence of the following: (i) confirmed AH, (ii) positive thy-roperoxidase/thyroglobulin antibodies [TPOAb/TgAb] without hypothyroidism, (iii) nonautoimmune hypothyroidism and (iv) SLE patients with neither...
December 2015: Clinical Endocrinology
https://www.readbyqxmd.com/read/25343509/the-coexistence-of-antiphospholipid-syndrome-and-systemic-lupus-erythematosus-in-colombians
#17
Juan-Sebastian Franco, Nicolás Molano-González, Monica Rodríguez-Jiménez, Yeny Acosta-Ampudia, Rubén D Mantilla, Jenny Amaya-Amaya, Adriana Rojas-Villarraga, Juan-Manuel Anaya
OBJECTIVES: To examine the prevalence and associated factors related to the coexistence of antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE) in a cohort of Colombian patients with SLE, and to discuss the coexistence of APS with other autoimmune diseases (ADs). METHOD: A total of 376 patients with SLE were assessed for the presence of the following: 1) confirmed APS; 2) positivity for antiphospholipid (aPL) antibodies without a prior thromboembolic nor obstetric event; and 3) SLE patients without APS nor positivity for aPL antibodies...
2014: PloS One
https://www.readbyqxmd.com/read/25270060/polyautoimmunity-in-a-greek-cohort-of-multiple-sclerosis
#18
G Deretzi, J Kountouras, S A Polyzos, E Koutlas, S-H Pelidou, G Xeromerisiou, C Zavos, I Tsiptsios
OBJECTIVES: The aim of this study was to assess the existence of polyautoimmunity in a Greek cohort of multiple sclerosis (MS), particularly multiple autoimmune syndrome (MAS), i.e., the presence of three or more distinct autoimmune disorders (ADs) in the same individual. METHODS: Cross-sectional control study. RESULTS: The overall prevalence of polyautoimmunity in 2140 MS patients (female to male ratio: 2.1:1) was 8.3% (vs 6.07% in 1580 matched control participants, P = 0...
April 2015: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/25228724/the-autoimmune-tautology-with-a-focus-on-antiphospholipid-syndrome
#19
J-S Franco, J-M Anaya
Autoimmune diseases (ADs) are often diagnosed according to classification criteria; however, they share similar subphenotypes including signs and symptoms, non-specific autoantibodies and other immune changes, which are prone to taxonomic problems. Polyautoimmunity is defined as the presence of more than one AD in a single patient. The close relationship between antiphospholipid syndrome (APS) and systemic lupus erythematosus has been studied throughout the years. However, APS may coexist with several other ADs confirming polyautoimmunity in this systemic disease...
October 2014: Lupus
https://www.readbyqxmd.com/read/24424171/the-diagnosis-and-clinical-significance-of-polyautoimmunity
#20
REVIEW
Juan-Manuel Anaya
Autoimmune diseases (ADs) are chronic and heterogeneous conditions that affect specific target organs or multiple organ systems. The chronic nature of these diseases places a significant burden on the utilization of medical care, direct and indirect economic costs, and quality of life. ADs are observed in genetically susceptible individuals in whom their clinical expression is modified by permissive and protective environments occurring over time. These are complex traits, meaning that their inheritance does not follow a single-gene dominant or single-gene recessive Mendelian law, and thus that they are polygenic...
April 2014: Autoimmunity Reviews
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