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https://www.readbyqxmd.com/read/29769450/heat-shock-protein-peptide-complex-96-vaccination-for-newly-diagnosed-glioblastoma-a-phase-i-single-arm-trial
#1
Nan Ji, Yang Zhang, Yunpeng Liu, Jian Xie, Yi Wang, Shuyu Hao, Zhixian Gao
BACKGROUND: Heat shock protein peptide complex-96 (HSPPC-96) triggers adaptive and innate antitumor immune responses. The safety and efficacy of HSPPC-96 vaccination was examined in patients with newly diagnosed glioblastoma multiforme (GBM). METHODS: In this open-label, single-arm, phase I study, adult patients were vaccinated with HSPPC-96 in combination with the standard treatment for newly diagnosed GBM after surgical resection. Primary endpoints were frequency of adverse events and progression-free survival (PFS) at 6 months...
May 17, 2018: JCI Insight
https://www.readbyqxmd.com/read/29764645/design-and-short-term-impact-of-an-event-to-promote-careers-in-clinical-pharmacy
#2
Sarah Ray, Andrew Ticcioni, Robert Mueller, Jessica Battaglia
BACKGROUND AND PURPOSE: There is a role for local pharmacy organizations to promote clinical pharmacy and increase awareness to both potential and current pharmacy students. The Greater Milwaukee College of Clinical Pharmacy (GMCCP) chapter sought to promote clinical pharmacy amongst current and prospective pharmacy students to increase the knowledge, awareness, and interest in clinical pharmacy. EDUCATIONAL ACTIVITY AND SETTING: Subcommittee members designed programming to introduce the basics of clinical pharmacy...
March 2018: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29723200/longitudinal-motor-performance-development-in-early-adolescence-and-its-relationship-to-adult-success-an-8-year-prospective-study-of-highly-talented-soccer-players
#3
Daniel Leyhr, Augustin Kelava, Johannes Raabe, Oliver Höner
Several talent identification and development (TID) programs in soccer have implemented diagnostics to measure players' motor performance. Yet, there is a lack of research investigating the relationship between motor development in adolescence and future, adult performance. This longitudinal study analyzed the three-year development of highly talented young soccer players' speed abilities and technical skills and examined the relevance of this development to their adult success. The current research sample consisted of N = 1,134 players born between 1993 and 1995 who were selected for the German Soccer Association's TID program and participated in nationwide motor diagnostics (sprinting, agility, dribbling, ball control, shooting) four times between the Under 12 (U12) and Under 15 (U15) age class...
2018: PloS One
https://www.readbyqxmd.com/read/29720575/prediction-of-acute-gvhd-and-relapse-by-metabolic-biomarkers-after-allogeneic-hematopoietic-stem-cell-transplantation
#4
Xiaojin Wu, Yiyu Xie, Chang Wang, Yue Han, Xiebing Bao, Shoubao Ma, Ahmet Yilmaz, Bingyu Yang, Yuhan Ji, Jinge Xu, Hong Liu, Suning Chen, Jianying Zhang, Jianhua Yu, Depei Wu
BACKGROUND: There are very few studies investigating metabolic biomarkers to predict acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic stem cell transplantation (HSCT). Metabolic models can provide a framework for analyzing the information-rich omics data sets in this setting. METHODS: Four hundred and fifty-six samples from one hundred and fourteen consecutive patients who underwent HSCT from January 2012 to May 2014 were collected for this study...
May 3, 2018: JCI Insight
https://www.readbyqxmd.com/read/29706641/australians-views-on-personal-genomic-testing-focus-group-findings-from-the-genioz-study
#5
Sylvia A Metcalfe, Chriselle Hickerton, Jacqueline Savard, Bronwyn Terrill, Erin Turbitt, Clara Gaff, Kathleen Gray, Anna Middleton, Brenda Wilson, Ainsley J Newson
Personal genomic testing provides healthy individuals with access to information about their genetic makeup for purposes including ancestry, paternity, sporting ability and health. Such tests are available commercially and globally, with accessibility expected to continue to grow, including in Australia; yet little is known of the views/expectations of Australians. Focus groups were conducted within a multi-stage, cross-disciplinary project (Genioz) to explore this. In mid-2015, 56 members of the public participated in seven focus groups, allocated into three age groups: 18-24, 25-49, and ≥50 years...
April 30, 2018: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/29695189/a-multidimensional-approach-to-talent-identification-and-selection-in-high-level-youth-australian-football-players
#6
Rhys Tribolet, Kyle J M Bennett, Mark L Watsford, Job Fransen
There is limited research in talent identification in youth Australian Football (AF), especially the factors that underpin selection into higher-level development programs. Therefore, this study explored age-related differences in high-level youth AF players and investigated characteristics influencing selection into a high-level development program. Anthropometry (stature, sitting height, body mass), maturity (estimated age at peak height velocity), motor competence (Körperkoordinationstest für Kinder), fitness (change of direction speed, lower body power and upper body muscular endurance) and coach skill ratings (kicking, marking and handballing) of 277 state academy players (U13-U15) were assessed...
April 26, 2018: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29691585/-neurobiological-mechanisms-of-autistic-savant-and-acquired-savant
#7
Yu Zhang, Victor Z Han
The autism spectrum is a pervasive developmental disorder characterized by profound social and verbal communication deficits, stereotypical motor behaviors, restricted interests, and cognitive abnormalities. It affects approximately 1% of children in most of the reported nations and regions. One of the most fascinating and mysterious features of autism, however, is the remarkable talent frequently found in people affected by it, namely autistic savant. A parallel and equally mysterious phenomenon is that some otherwise normal and ordinary individuals develop similarly remarkable talent after brain injuries, a disorder known as acquired savant...
April 25, 2018: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/29687690/anthropometric-characteristics-of-top-class-olympic-race-walkers
#8
Josu Gomez-Ezeiza, Nicholas Tam, Jon Torres-Unda, Cristina Granados, Jordan Santos-Concejero
BACKGROUND: Typical training programmes in elite race walkers involve high training volumes at low and moderate intensities, which have been reported to induce functional and structural adaptations at an anthropometric level. Since anthropometrical variables are closely related to movement efficiency and performance in endurance events, the aim of this study was to describe the anthropometric profile of world-class race walkers. METHODS: Twenty-nine world-class race walkers (21 men & 8 women) participated in this study...
April 20, 2018: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/29683793/creating-a-professional-development-platform-to-transform-social-work-clinical-practice-in-health-care
#9
Nancy Xenakis
Since U.S. Congress' 2010 passing of the Affordable Care Act and the creation of numerous care coordination programs, Mount Sinai Hospital's Department of Social Work Services has experienced exponential growth. The Department is deeply committed to recruiting and developing the most talented social workers to best meet the needs of patients and family caregivers and to serve as integral, valued members of interdisciplinary care teams. Traditional learning methods are insufficient for a staff of hundreds, given the changes in health care and the complexity of the work...
July 2018: Social Work in Health Care
https://www.readbyqxmd.com/read/29657853/training-scientists-as-future-industry-leaders-teaching-translational-science-from-an-industry-executive-s-perspective
#10
Gloria Lee, Jay D Kranzler, Ravichandran Ramasamy, Gabrielle Gold-von Simson
PhDs and post-doctoral biomedical graduates, in greater numbers, are choosing industry based careers. However, most scientists do not have formal training in business strategies and venture creation and may find senior management positions untenable. To fill this training gap, "Biotechnology Industry: Structure and Strategy" was offered at New York University School of Medicine (NYUSOM). The course focuses on the business aspects of translational medicine and research translation and incorporates the practice of business case discussions, mock negotiation, and direct interactions into the didactic...
2018: Journal of Translational Science
https://www.readbyqxmd.com/read/29624143/development-and-validation-of-health-service-management-competencies
#11
Zhanming Liang, Peter F Howard, Sandra Leggat, Timothy Bartram
Purpose The importance of managerial competencies in monitoring and improving the performance of organisational leaders and managers is well accepted. Different processes have been used to identify and develop competency frameworks or models for healthcare managers around the world to meet different contextual needs. The purpose of the paper is to introduce a validated process in management competency identification and development applied in Australia - a process leading to a management competency framework with associated behavioural items that can be used to measure core management competencies of health service managers...
April 9, 2018: Journal of Health Organization and Management
https://www.readbyqxmd.com/read/29614751/annexin-a1-uncovering-the-many-talents-of-an-old-protein
#12
REVIEW
Madeeha H Sheikh, Egle Solito
Annexin A1 (ANXA1) has long been classed as an anti-inflammatory protein due to its control over leukocyte-mediated immune responses. However, it is now recognized that ANXA1 has widespread effects beyond the immune system with implications in maintaining the homeostatic environment within the entire body due to its ability to affect cellular signalling, hormonal secretion, foetal development, the aging process and development of disease. In this review, we aim to provide a global overview of the role of ANXA1 covering aspects of peripheral and central inflammation, immune repair and endocrine control with focus on the prognostic, diagnostic and therapeutic potential of the molecule in cancer, neurodegeneration and inflammatory-based disorders...
March 31, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29609273/-talking-about-the-discipline-construction-and-development-of-burn-from-five-ideas
#13
G H Guo
Discipline construction is an important aspect of hospital modernization management and construction. The level of medical treatment, education, and scientific research could be assured and improved through discipline construction, which could speed up the talent training, promote science and technology innovation, and realize the sustainable development of hospital. At present, most of the hospital management models adopt the two ranks of the hospital and department. The manager of a department must grasp medical treatment, education, scientific research, and discipline construction steadily...
March 20, 2018: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29609272/-discipline-construction-is-the-theme-of-the-development-of-burn-surgery
#14
C Y Jia
Discipline construction is the core element of department development, including discipline structure setting, scale, equipment, medical workers structure, clinical feature and advantage, talent training, teaching level, scientific research level, management system, and cultural construction of department. As leader and engine of discipline construction, directors' ability is an important factor for discipline construction. Clinical characteristic is the basis of discipline construction; innovation actuation is the essence of discipline construction; talents training is the guarantee of discipline construction; scientific research is the wing of discipline construction; cultural construction is the hot spring of discipline construction...
March 20, 2018: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29605513/pharmacovigilance-in-crisis-drug-safety-at-a-crossroads
#15
John Price
Pharmacovigilance (PV) is under unprecedented stress from fundamental changes in a booming pharmaceutical industry, from the challenges of creating and maintaining an increasingly complex PV system in a globally diverse regulatory environment, and from unpredicted consequences of historical PV cost-reduction strategies. At the same time, talent availability lags demand, and many PV professionals may no longer be finding personal fulfillment in their careers. The situation creates risks for companies. Advantages and disadvantages of potential strategies to address this increasing problem at a corporate and industry level and in collaboration with regulatory agencies are discussed, as well as opportunities to adopt new technologies, including artificial intelligence and machine-learning to automate pharmacovigilance operations...
March 28, 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29564125/therapeutics-discovery-from-bench-to-first-in-human-trials
#16
Ensaf M Al-Hujaily, Tanvir Khatlani, Zeyad Alehaideb, Rizwan Ali, Bader Almuzaini, Bahauddeen M Alrfaei, Jahangir Iqbal, Imadul Islam, Shuja Malik, Bader A Marwani, Salam Massadeh, Atef Nehdi, Barrak Alsomaie, Bader Debasi, Ibraheem Bushnak, Saeed Noibi, Syed Hussain, Wahid Abdul Wajid, Jean-Pierre Armand, Sheraz Gul, Julen Oyarzabal, Rana Rais, Chas Bountra, Ahmed Alaskar, Bander Al Knawy, Mohamed Boudjelal
The 'Therapeutics discovery: From bench to first in-human trials' conference, held at the King Abdullah International Medical Research Center (KAIMRC), Ministry of National Guard Health Affairs (MNGHA), Kingdom of Saudi Arabia (KSA) from October 10-12, 2017, provided a unique opportunity for experts worldwide to discuss advances in drug discovery and development, focusing on phase I clinical trials. It was the first event of its kind to be hosted at the new research center, which was constructed to boost drug discovery and development in the KSA in collaboration with institutions, such as the Academic Drug Discovery Consortium in the United States of America (USA), Structural Genomics Consortium of the University of Oxford in the United Kingdom (UK), and Institute of Materia Medica of the Chinese Academy of Medical Sciences in China...
March 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29552804/-evidence-based-chinese-medicine%C3%AF-theory-and-practice
#17
Jun-Hua Zhang, You-Ping Li, Bo-Li Zhang
The introduction and popularization of evidence-based medicine has opened up a new research field of clinical efficacy evaluation of traditional Chinese medicine(TCM), produced new research ideas and methods, and promoted the progress of clinical research of TCM. After about 20 years assiduous study and earnest practice, the evidence based evaluation method and technique, which conforms to the characteristics of TCM theory and practice, has been developing continuously. Evidence-based Chinese medicine (EBCM) has gradually formed and become an important branch of evidence-based medicine...
January 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29528993/biomedical-research-priorities-for-modern-syphilis-clinical-management-diagnosis-and-vaccines-overview-and-commentary-for-unit-1
#18
Ellen N Kersh, Sheila A Lukehart
The first session at the 2016 Syphilis Summit provided an opportunity for laboratory researchers and clinicians to comment on gaps in biomedical knowledge and technologies. Predominant themes in the presentations and discussion included the need for optimization of existing diagnostic tests, commercial availability and FDA approval of nucleic acid amplification tests for primary and secondary syphilis, development of sensitive and specific new blood tests for diagnosis of active (vs. treated) syphilis infection, clarification of the best measures for adequacy of response to treatment, continued study of complications of syphilis including neuro- and ocular syphilis, and development of a safe and effective vaccine that will protect against transmission and complications of disseminated infection (including congenital and neurosyphilis)...
March 9, 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29515500/-the-early-specialised-bird-catches-the-worm-a-specialised-sampling-model-in-the-development-of-football-talents
#19
Roland Sieghartsleitner, Claudia Zuber, Marc Zibung, Achim Conzelmann
Characteristics of learning activities in early sport participation play a key role in the development of the sporting talent. Therefore, pathways of specialisation or diversification/sampling are as well debated as the implementation of practice- or play-oriented activities. The related issues are currently perceived as a two-dimensional construct of domain specificity and performance orientation . In this context, it has been shown that early specialisation, with experiences in practice and play, has led to Swiss junior national team football players reaching higher success levels as adults...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29513093/kicking-performance-in-young-u9-to-u20-soccer-players-assessment-of-velocity-and-accuracy-simultaneously
#20
Luiz H P Vieira, Sérgio A Cunha, Renato Moraes, Fabio A Barbieri, Rodrigo Aquino, Lucas de P Oliveira, Martina Navarro, Bruno L S Bedo, Paulo R P Santiago
PURPOSE: The purpose of this study was to compare the kicking performance of young soccer players in the U9 to U20 age groups. METHOD: Three hundred and sixty-six Brazilian players were evaluated on an official pitch using three-dimensional kinematics to measure (300 Hz) ball velocity (Vball ), foot velocity (Vfoot ), Vball /Vfoot ratio, last stride length, and distance between the support foot and the ball. Simultaneously, a two-dimensional procedure was also conducted to compute (60 Hz) the mean radial error, bivariate variable error, and accuracy...
March 7, 2018: Research Quarterly for Exercise and Sport
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