keyword
https://read.qxmd.com/read/38546978/role-of-kcnk3-dysfunction-in-dasatinib-associated-pah-and-endothelial-cell-dysfunction
#21
JOURNAL ARTICLE
Hélène Le Ribeuz, Anaïs Saint-Martin Willer, Benoit Chevalier, Maria Sancho, Bastien Masson, Mélanie Eyries, Vincent Jung, Ida Chiara Guerrera, Mary Dutheil, Kristelle El Jekmek, Loann Laubry, Gilles Carpentier, Francisco Perez-Vizcaino, Ly Tu, Christophe Guignabert, Marie-Camille Chaumais, Christine Péchoux, Marc Humbert, Alexandre Hinzpeter, Olaf Mercier, Véronique Capuano, David Montani, Fabrice Antigny
Pulmonary arterial hypertension (PAH) is severe cardiopulmonary disease that may be triggered by exposure to drugs such as dasatinib or facilitated by genetic predispositions. The incidence of dasatinib-associated PAH is estimated at 0.45%, suggesting individual predispositions. The mechanisms of dasatinib-associated PAH are still incomplete. We discovered a KCNK3 gene (coding for outward K+ channel) variant in a patient with dasatinib-associated PAH, and we investigated the impact of this variant on KCNK3 function...
March 28, 2024: American Journal of Respiratory Cell and Molecular Biology
https://read.qxmd.com/read/38546871/assigning-a-social-status-from-face-adornments-an-fmri-study
#22
JOURNAL ARTICLE
M Salagnon, F d'Errico, S Rigaud, E Mellet
For at least 150,000 years, the human body has been culturally modified by the wearing of personal ornaments and probably by painting with red pigment. The present study used functional magnetic resonance imaging to explore the brain networks involved in attributing social status from face decorations. Results showed the fusiform gyrus, orbitofrontal cortex, and salience network were involved in social encoding, categorization, and evaluation. The hippocampus and parahippocampus were activated due to the memory and associative skills required for the task, while the inferior frontal gyrus likely interpreted face ornaments as symbols...
March 28, 2024: Brain Structure & Function
https://read.qxmd.com/read/38546819/pe-ynet-a-novel-attention-based-multi-task-model-for-pulmonary-embolism-detection-using-ct-pulmonary-angiography-ctpa-scan-images
#23
JOURNAL ARTICLE
G R Hemalakshmi, M Murugappan, Mohamed Yacin Sikkandar, D Santhi, N B Prakash, A Mohanarathinam
Pulmonary Embolism (PE) has diverse manifestations with different etiologies such as venous thromboembolism, septic embolism, and paradoxical embolism. In this study, a novel attention-based multi-task model is proposed for PE segmentation and detection from Computed Tomography Pulmonary Angiography (CTPA) images. A Y-Net architecture is used to implement this model, which facilitates segmentation and classification jointly, improving performance and efficiency. It is leveraged with Multi Head Attention (MHA), which allows the model to focus on important regions of the image while suppressing irrelevant information, improving the accuracy of the segmentation and detection tasks...
March 28, 2024: Physical and engineering sciences in medicine
https://read.qxmd.com/read/38546755/topical-review-task-shifting-and-the-recruitment-and-retention-of-eye-health-workers-in-underserved-areas
#24
JOURNAL ARTICLE
Joel G Somerville, Niall C Strang, Sven Jonuscheit
UNLABELLED: Many populations experience difficulty accessing eye care, especially in rural areas. Implementing workforce recruitment and retention strategies, as well as task shifting through widening scope of practice, can improve eye care accessibility. This article provides novel evidence on the compatibility of these strategies aimed at enhancing ophthalmic workforce recruitment, retention, and efficacy. PURPOSE: The global burden of blindness is unequally distributed, affects rural areas more, and is frequently associated with limited access to eye care...
March 1, 2024: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://read.qxmd.com/read/38546663/physical-activity-using-a-wearable-device-as-an-alternative-to-performance-status-in-patients-with-advanced-lung-cancer
#25
JOURNAL ARTICLE
Kentaro Ito, Yuta Suzuki, Tadashi Sakaguchi, Kentaro Fujiwara, Yoichi Nishii, Hiroki Yasui, Osamu Taguchi, Osamu Hataji
IMPORTANCE: The Eastern Cooperative Oncology Group Performance Status (ECOG PS) is extensively used to guide treatment decisions in patients with advanced lung cancer. However, its assessment is subjective, potentially leading to discordance among observers. OBJECTIVE: To investigate the association between measured physical activity and ECOG PS, as well as the potential prognostic value of physical activity measurements in patients with advanced lung cancer. DESIGN, SETTING, AND PARTICIPANTS: This single-institution, prospective observational study enrolled 119 patients with advanced lung cancer scheduled to receive systemic therapy as outpatients at Matsusaka Municipal Hospital in Mie, Japan...
March 28, 2024: JAMA Oncology
https://read.qxmd.com/read/38546644/perspectives-of-oncologists-on-the-ethical-implications-of-using-artificial-intelligence-for-cancer-care
#26
JOURNAL ARTICLE
Andrew Hantel, Thomas P Walsh, Jonathan M Marron, Kenneth L Kehl, Richard Sharp, Eliezer Van Allen, Gregory A Abel
IMPORTANCE: Artificial intelligence (AI) tools are rapidly integrating into cancer care. Understanding stakeholder views on ethical issues associated with the implementation of AI in oncology is critical to optimal deployment. OBJECTIVE: To evaluate oncologists' views on the ethical domains of the use of AI in clinical care, including familiarity, predictions, explainability (the ability to explain how a result was determined), bias, deference, and responsibilities...
March 4, 2024: JAMA Network Open
https://read.qxmd.com/read/38546627/semantic-facilitation-in-blocked-picture-categorization-some-data-and-considerations-regarding-task-selection
#27
JOURNAL ARTICLE
Stefan Wöhner, Jana Luckow, Miriam Brandt, Jens Stahlmann, Annika Werwach, Jörg D Jescheniak
Semantic context effects in picture naming and categorization tasks are central to the development and evaluation of current models of word production. When pictures are named in a semantically blocked context, response latencies are delayed. Belke (2013) found that when the naming task was replaced with a semantic categorization task (natural vs. man-made), response latencies were facilitated. From this pattern, she concluded that semantic interference in blocked picture naming has its locus at the lexical level but its origin at the preceding semantic level...
March 28, 2024: Journal of Experimental Psychology. Human Perception and Performance
https://read.qxmd.com/read/38546625/speeded-classification-of-visual-events-is-sensitive-to-crossmodal-intensity-correspondence
#28
JOURNAL ARTICLE
Robert Carl Gunnar Johansson, Paul Kelber, Rolf Ulrich
Crossmodal correspondences refer to systematic associations between stimulus attributes encountered in different sensory modalities. These correspondences can be probed in the speeded classification task where they tend to produce congruency effects. This study aimed to replicate and extend previous work conducted by Marks (1987, Experiment 3, Journal of Experimental Psychology: Human Perception and Performance , Vol. 13, No. 3, 384-394) which demonstrated a crossmodal correspondence between auditory and visual intensity attributes...
March 28, 2024: Journal of Experimental Psychology. Human Perception and Performance
https://read.qxmd.com/read/38546587/saccades-to-partially-occluded-objects-perceptual-completion-mediates-oculomotor-control
#29
JOURNAL ARTICLE
Michael L Paavola, Andrew Hollingworth, Cathleen M Moore
Oculomotor behavior typically consists of directing gaze to objects in complex scenes for the purpose of extracting detailed perceptual information. Here, we probed the nature of the visual representations over which saccades to objects are computed. We contrasted an image-based oculomotor control hypothesis, holding that saccades are computed solely over information explicit in the retinal image, and an object-based oculomotor control hypothesis, holding that saccades are computed over object representations reflecting the three-dimensional structure of the scene...
March 1, 2024: Journal of Vision
https://read.qxmd.com/read/38546580/on-parrots-delay-of-gratification-executive-function-and-how-sometimes-we-do-the-best-we-can
#30
JOURNAL ARTICLE
Michael J Beran
Engaging executive functions provides an individual with the means to engage in cognitive control by adjusting to the environment and processing information in a way that leads to optimal outcomes. There are some claims that explicit training on certain executive functioning abilities provides benefits beyond the training tasks, but other studies indicate that this may not be true or may be limited based on age and other factors. This same mixed pattern has been reported with nonhuman species, where training or even experience in one specific area, like inhibition, sometimes leads to positive transfer in new but similar tasks that presumably also require executive functions...
February 2024: Journal of Comparative Psychology
https://read.qxmd.com/read/38546549/examining-the-reliability-of-the-emotional-conflict-resolution-and-adaptation-effects-in-the-emotional-conflict-task-via-secondary-data-analysis-systematic-review-and-meta-analysis
#31
JOURNAL ARTICLE
Jiani Yin, Yi Wang, Ottmar V Lipp, Leah M Mayo, Luke J Ney
The emotional conflict task measures emotional conflict resolution and adaptation, but some studies are unable to find resolution or adaptation effects using this task. We examined boundary conditions and replicability of the emotional conflict resolution and adaptation effects through secondary data analysis, systematic review, and meta-analysis of studies in the field. In our data, we were unable to fully replicate the emotional conflict resolution or adaptation effects and found that most studies using this task ( n = 94) do not report analysis of emotional conflict resolution, with only 28% ( n = 26) studies doing so...
March 28, 2024: Journal of Experimental Psychology. General
https://read.qxmd.com/read/38546547/limitations-to-optimal-search-in-naturalistic-active-learning
#32
JOURNAL ARTICLE
Lisheng He, Russell Richie, Sudeep Bhatia
Optimality in active learning is under intense debate in numerous disciplines. We introduce a new empirical paradigm for studying naturalistic active learning, as well as new computational tools for jointly modeling algorithmic and rational theories of information search. Participants in our task can ask questions and learn about hundreds of everyday items but must retrieve queried items from memory. To maximize information gain, participants need to retrieve sequences of dissimilar items. In eight experiments ( N = 795), we find that participants are unable to do this...
March 28, 2024: Journal of Experimental Psychology. General
https://read.qxmd.com/read/38546511/a-case-series-of-the-royal-perth-hospital-cannula-first-approach-in-the-can-t-intubate-can-t-oxygenate-scenario
#33
JOURNAL ARTICLE
Andrew Mb Heard, David A Lacquiere, Helen L Gordon, Scott G Douglas, Hans J Avis
At the Royal Perth Hospital, we have been developing and teaching a can't intubate, can't oxygenate (CICO) rescue algorithm for over 19 years, based on live animal simulation. The algorithm involves a 'cannula-first' approach, with jet oxygenation and progression to scalpel techniques if required in a stepwise fashion. There is little reported experience of this approach to the CICO scenario in humans. We present eight cases in which a cannula-first Royal Perth Hospital approach was successfully implemented during an airway crisis...
March 28, 2024: Anaesthesia and Intensive Care
https://read.qxmd.com/read/38546323/review-and-meta-analysis-of-the-genetic-minimal-cut-set-approach-for-gene-essentiality-prediction-in-cancer-metabolism
#34
JOURNAL ARTICLE
Danel Olaverri-Mendizabal, Luis V Valcárcel, Naroa Barrena, Carlos J Rodríguez, Francisco J Planes
Cancer metabolism is a marvellously complex topic, in part, due to the reprogramming of its pathways to self-sustain the malignant phenotype in the disease, to the detriment of its healthy counterpart. Understanding these adjustments can provide novel targeted therapies that could disrupt and impair proliferation of cancerous cells. For this very purpose, genome-scale metabolic models (GEMs) have been developed, with Human1 being the most recent reconstruction of the human metabolism. Based on GEMs, we introduced the genetic Minimal Cut Set (gMCS) approach, an uncontextualized methodology that exploits the concepts of synthetic lethality to predict metabolic vulnerabilities in cancer...
March 27, 2024: Briefings in Bioinformatics
https://read.qxmd.com/read/38546259/virtual-reality-adaptive-training-for-personalized-stress-inoculation
#35
JOURNAL ARTICLE
Tor Finseth, Michael C Dorneich, Nir Keren, Warren D Franke, Stephen Vardeman
OBJECTIVE: To evaluate a personalized adaptive training program designed for stress prevention using graduated stress exposure. BACKGROUND: Astronauts in the high-risk space mission environment are prone to performance-impairing stress responses, making preemptive stress inoculation essential for their training. METHODS: This work developed an adaptive virtual reality-based system that adjusts environmental stressors based on real-time stress indicators to optimize training stress levels...
March 28, 2024: Human Factors
https://read.qxmd.com/read/38546203/task-anchored-grid-cell-firing-is-selectively-associated-with-successful-path-integration-dependent-behaviour
#36
JOURNAL ARTICLE
Harry Clark, Matthew F Nolan
Grid firing fields have been proposed as a neural substrate for spatial localisation in general or for path integration in particular. To distinguish these possibilities, we investigate firing of grid and non-grid cells in the mouse medial entorhinal cortex during a location memory task. We find that grid firing can either be anchored to the task environment, or can encode distance travelled independently of the task reference frame. Anchoring varied between and within sessions, while spatial firing of non-grid cells was either coherent with the grid population, or was stably anchored to the task environment...
March 28, 2024: ELife
https://read.qxmd.com/read/38545906/investigating-linguistic-alignment-in-collaborative-dialogue-a-study-of-syntactic-and-lexical-patterns-in-middle-school-students
#37
JOURNAL ARTICLE
Xiaoyi Tian, Amanda E Griffith, Zane Price, Kristy Elizabeth Boyer, Kevin Tang
Linguistic alignment, the tendency of speakers to share common linguistic features during conversations, has emerged as a key area of research in computer-supported collaborative learning. While previous studies have shown that linguistic alignment can have a significant impact on collaborative outcomes, there is limited research exploring its role in K-12 learning contexts. This study investigates syntactic and lexical linguistic alignments in a collaborative computer science-learning corpus from 24 pairs (48 individuals) of middle school students (aged 11-13)...
March 28, 2024: Language and Speech
https://read.qxmd.com/read/38545877/the-relationship-between-executive-functions-self-reflection-and-insight-across-adulthood
#38
JOURNAL ARTICLE
Yasemin Sohtorik İlkmen, Ezgi Soncu Büyükişcan
OBJECTIVE: Research suggests that executive functions and metacognitive abilities, including self-reflection and insight, may share underlying mechanisms since both rely on top-down cognitive processes and require self-regulation. However, these relationships have not been thoroughly examined by empirical research. The current study investigated the relationship between insight, self-reflection, and executive functions cross-sectionally across different stages of aging. METHODS: Participants were 1284 (655 men and 629 women) cognitively healthy community dwellers with an age range of 18-89 years (M = 47...
March 28, 2024: Experimental Aging Research
https://read.qxmd.com/read/38545857/ovonic-threshold-switching-based-artificial-afferent-neurons-for-thermal-in-sensor-computing
#39
JOURNAL ARTICLE
Kai Li, Jiaping Yao, Peng Zhao, Yunhao Luo, Xiang Ge, Rui Yang, Xiaomin Cheng, Xiangshui Miao
Artificial afferent neurons in the sensory nervous system inspired by biology have enormous potential for efficiently perceiving and processing environmental information. However, the previously reported artificial afferent neurons suffer from two prominent challenges: considerable power consumption and limited scalability efficiency. Herein, addressing these challenges, a bioinspired artificial thermal afferent neuron based on a N-doped SiTe ovonic threshold switching (OTS) device is presented for the first time...
March 28, 2024: Materials Horizons
https://read.qxmd.com/read/38545838/general-neurology-current-challenges-and-future-implications
#40
JOURNAL ARTICLE
Claudio Lino Alberto Bassetti, Alice Accorroni, Astri Arnesen, Hamidon Bin Basri, Thomas Berger, Peter Berlit, Paul Boon, Augustina Charway-Felli, Jera Kruja, Steven Lewis, Michael Markowski, Marco Tulio Medina, Pamela McCombe, Elena Moro, Serefnur Ozturk, Paul Smith, Vladimira Vuletic
BACKGROUND AND PURPOSE: In the coming decades, the world will face an increasing burden of neurological disorders (ND) and an urgent need to promote brain health. These challenges contrast with an insufficient neurological workforce in most countries, as well as decreasing numbers of general neurologists and neurologists attracted to work in general neurology (GN). This white paper aims to review the current situation of GN and reflect on its future. METHODS: The European Academy of Neurology (EAN) task force (TF) met nine times between November 2021 and June 2023...
March 28, 2024: European Journal of Neurology
keyword
keyword
93363
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.