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https://www.readbyqxmd.com/read/29036877/a-hybrid-cnn-feature-model-for-pulmonary-nodule-malignancy-risk-differentiation
#1
Huafeng Wang, Tingting Zhao, Lihong Connie Li, Haixia Pan, Wanquan Liu, Haoqi Gao, Fangfang Han, Yuehai Wang, YiFang Qi, Zhengrong Liang
The malignancy risk differentiation of pulmonary nodule is one of the most challenge tasks of computer-aided diagnosis (CADx). Most recently reported CADx methods or schemes based on texture and shape estimation have shown relatively satisfactory on differentiating the risk level of malignancy among the nodules detected in lung cancer screening. However, the existing CADx schemes tend to detect and analyze characteristics of pulmonary nodules from a statistical perspective according to local features only. Enlightened by the currently prevailing learning ability of convolutional neural network (CNN), which simulates human neural network for target recognition and our previously research on texture features, we present a hybrid model that takes into consideration of both global and local features for pulmonary nodule differentiation using the largest public database founded by the Lung Image Database Consortium and Image Database Resource Initiative (LIDC-IDRI)...
October 10, 2017: Journal of X-ray Science and Technology
https://www.readbyqxmd.com/read/29036874/development-of-a-device-to-reduce-the-risk-of-injury-in-handling-unstable-loads
#2
Mohamed Zaki Ramadan, Mohammed Alkahtani
BACKGROUND: Manual material handling (MMH) task is the most common cause of work-related musculoskeletal disorders (MSDs). Operators carrying unstable loads were recently shown to be at greater risk of back injury compared to workers carrying stable loads. OBJECTIVE: This study focused on developing a device to minimize trunk muscle activity and cardiovascular demand while handling a 19-liter bottle. METHOD: After evaluating several designs, one was selected to be developed, manufactured and tested through an experimental study...
October 10, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/29036861/task-intensity-influences-upper-limb-and-torso-kinematics-during-two-common-overhead-functional-capacity-evaluation-tasks
#3
Angelica E Lang, Clark R Dickerson
BACKGROUND: The Functional Capacity Evaluation (FCE) is a tool used in the return-to-work process to guide treatment and decision making. Individual abilities and maximum capacity can be determined through visual observations of changes in mechanics as intensity increases. OBJECTIVE: The purpose of this study was to determine kinematic differences between sexes and intensity levels of two common FCE tasks to establish normative behaviours. METHODS: Upper limb and torso kinematics were collected from 30 participants as they performed the overhead lift and overhead work FCE tasks...
October 8, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/29036860/prevalence-of-work-related-musculoskeletal-injuries-among-south-indian-hand-screen-printing-workers
#4
S Shankar, R Naveen Kumar, P Mohankumar, Srinivasan Jayaraman
BACKGROUND: Hand screen-printing (HSP) plays a predominant role in textile industries in developing countries. Workers from HSP industry were mostly affected by musculoskeletal injury due to monotonous, and prolonged work nature and poor workplace environment. OBJECTIVE: The present study aims to investigate the prevalence of work-related musculoskeletal disorder (MSD) symptoms and risk factors associated among the HSP industry workers. METHODS: Cochran's sample size for categorical data was used to select 385 HSP workers of 1000 samples from various provinces of Tamil Nadu, INDIA...
October 8, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/29036857/outcomes-of-safe-patient-handling-and-mobilization-programs-a-meta-analysis
#5
Erin Teeple, Jamie E Collins, Swastina Shrestha, Jack T Dennerlein, Elena Losina, Jeffrey N Katz
BACKGROUND: Variability in patient care settings and the range of patient handling tasks present challenges in developing and evaluating safe patient handling and mobilization (SPHM) programs. OBJECTIVE: We performed a systematic meta-analysis of SPHM program evaluations. METHODS: Systematic literature review identified published SPHM program evaluations. Injury Rate Ratios (IRR), pre- to post-intervention, were used to estimate intervention effects and to examine the influence of patient care level, program components, and follow-up time using meta-regression...
October 8, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/29036856/informal-care-employment-and-quality-of-life-barriers-and-facilitators-to-combining-informal-care-and-work-participation-for-healthcare-professionals
#6
Eveline Heitink, Yvonne Heerkens, Josephine Engels
BACKGROUND: In The Netherlands, one out of six Dutch employees has informal care tasks; in the hospital and healthcare sector, this ratio is one out of four workers. Informal carers experience problems with the combination of work and informal care. In particular, they have problems with the burden of responsibility, a lack of independence and their health. These problems can reveal themselves in a variety of mental and physical symptoms that can result in absenteeism, reduction or loss of (work) participation, reduction of income, and even social isolation...
October 8, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/29036853/smooth-leader-or-sharp-follower-playing-the-mirror-game-with-a-robot
#7
Shir Kashi, Shelly Levy-Tzedek
BACKGROUND: The increasing number of opportunities for human-robot interactions in various settings, from industry through home use to rehabilitation, creates a need to understand how to best personalize human-robot interactions to fit both the user and the task at hand. In the current experiment, we explored a human-robot collaborative task of joint movement, in the context of an interactive game. OBJECTIVE: We set out to test people's preferences when interacting with a robotic arm, playing a leader-follower imitation game (the mirror game)...
October 9, 2017: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/29036852/rehabilitation-modality-and-onset-differentially-influence-whisker-sensory-hypersensitivity-after-diffuse-traumatic-brain-injury-in-the-rat
#8
Theresa Currier Thomas, Ellen Magee Stockhausen, L Matthew Law, Aida Khodadad, Jonathan Lifshitz
BACKGROUND: As rehabilitation strategies advance as therapeutic interventions, the modality and onset of rehabilitation after traumatic brain injury (TBI) are critical to optimize treatment. Our laboratory has detected and characterized a late-onset, long-lasting sensory hypersensitivity to whisker stimulation in diffuse brain-injured rats; a deficit that is comparable to visual or auditory sensory hypersensitivity in humans with an acquired brain injury. OBJECTIVE: We hypothesize that the modality and onset of rehabilitation therapies will differentially influence sensory hypersensitivity in response to the Whisker Nuisance Task (WNT) as well as WNT-induced corticosterone (CORT) stress response in diffuse brain-injured rats and shams...
October 9, 2017: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/29036840/efficacy-of-memory-aids-after-traumatic-brain-injury-a-single-case-series
#9
Hannah R Bos, Duncan R Babbage, Janet M Leathem
BACKGROUND: Individuals living with traumatic brain injury commonly have difficulties with prospective memory- the ability to remember a planned action at the intended time. Traditionally a memory notebook has been recommended as a compensatory memory aid. Electronic devices have the advantage of providing a cue at the appropriate time to remind participants to refer to the memory aid and complete tasks. Research suggests these have potential benefit in neurorehabilitation. OBJECTIVE: This study aimed to investigate the efficacy of a memory notebook and specifically a smartphone as a compensatory memory aid...
October 10, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/29036826/what-can-quantitative-gait-analysis-tell-us-about-dementia-and-its-subtypes-a-structured-review
#10
Ríona Mc Ardle, Rosie Morris, Joanna Wilson, Brook Galna, Alan J Thomas, Lynn Rochester
Distinguishing dementia subtypes can be difficult due to similarities in clinical presentation. There is increasing interest in discrete gait characteristics as markers to aid diagnostic algorithms in dementia. This structured review explores the differences in quantitative gait characteristics between dementia and healthy controls, and between four dementia subtypes under single-task conditions: Alzheimer's disease (AD), dementia with Lewy bodies and Parkinson's disease dementia, and vascular dementia. Twenty-six papers out of an initial 5,211 were reviewed and interpreted using a validated model of gait...
October 7, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29036758/comparison-of-single-task-versus-dual-task-for-listening-effort
#11
Chanbeom Kwak, Woojae Han
Background and Objectives: Depending on the kind of task and/or material, listeners sometimes need to pay attention to understand communication. The present study aimed to estimate a listener's amount of effort needed to understand communication by using recognition score and response time as a function of signal-to-noise ratio (SNR) and to confirm his/ her task dependency for listening effort. Subjects and Methods: Forty-eight young adults with normal hearing participated in the study...
October 17, 2017: Journal of Audiology & Otology
https://www.readbyqxmd.com/read/29036616/deeploc-prediction-of-protein-subcellular-localization-using-deep-learning
#12
José Juan Almagro Armenteros, Casper Kaae Sønderby, Søren Kaae Sønderby, Henrik Nielsen, Ole Winther
Motivation: The prediction of eukaryotic protein subcellular localization is a well-studied topic in bioinformatics due to its relevance in proteomics research. Many machine learning methods have been successfully applied in this task, but in most of them, predictions rely on annotation of homologues from knowledge databases. For novel proteins where no annotated homologues exist, and for predicting the effects of sequence variants, it is desirable to have methods for predicting protein properties from sequence information only...
July 7, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29036558/methrafo-medip-seq-methylation-estimate-using-a-random-forest-regressor
#13
Jun Ding, Ziv Bar-Joseph
Motivation: Profiling of genome wide DNA methylation is now routinely performed when studying development, cancer and several other biological processes. Although Whole genome Bisulfite Sequencing provides high-quality methylation measurements at the resolution of nucleotides, it is relatively costly and so several studies have used alternative methods for such profiling. One of the most widely used low cost alternatives is MeDIP-Seq. However, MeDIP-Seq is biased for CpG enriched regions and thus its results need to be corrected in order to determine accurate methylation levels...
July 13, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29036535/ploc-manimal-predict-subcellular-localization-of-animal-proteins-with-both-single-and-multiple-sites
#14
Xiang Cheng, Shu-Guang Zhao, Wei-Zhong Lin, Xuan Xiao, Kuo-Chen Chou
Motivation: Cells are deemed the basic unit of life. However, many important functions of cells as well as their growth and reproduction are performed via the protein molecules located at their different organelles or locations. Facing explosive growth of protein sequences, we are challenged to develop fast and effective method to annotate their subcellular localization. However, this is by no means an easy task. Particularly, mounting evidences have indicated proteins have multi-label feature meaning that they may simultaneously exist at, or move between, two or more different subcellular location sites...
July 24, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29036532/behavioral-pattern-separation-and-its-link-to-the-neural-mechanisms-of-fear-generalization
#15
Iris Lange, Liesbet Goossens, Stijn Michielse, Jindra Bakker, Shmuel Lissek, Silvia Papalini, Simone Verhagen, Nicole Leibold, Machteld Marcelis, Marieke Wichers, Ritsaert Lieverse, Jim van Os, Therese van Amelsvoort, Koen Schruers
Fear generalization is a prominent feature of anxiety disorders and post-traumatic stress disorder. It is defined as enhanced fear responding to a stimulus that bears similarities, but is not identical to a threatening stimulus. Pattern separation, a hippocampal-dependent process, is critical for stimulus discrimination; it transforms similar experiences or events into non-overlapping representations. The current study is the first in humans to investigate the extent to which fear generalization relies on behavioral pattern separation abilities...
September 26, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/29036478/unraveling-the-fine-tuned-lemon-coloration-of-a-pierid-butterfly-catopsilia-pomona
#16
Monalisa Mishra, Ashutosh Choudhury, P Sagar Achary, Harekrushna Sahoo
Butterflies wings possess different types of scales to perform diverse functions. Each scale has many nano and microstructures, which interferes with light, resulting in unique coloration for each butterfly. Besides coloration, the arrangement of scales further helps in giving better survivability. Thus, analysis of wing pattern provides an overall idea about adaptation and activity of the animal. The current study deciphers the structure and composition of a wing of a pierid butterfly Catopsilia pomona, which remains active at 42°C at which temperature all other butterflies face a tougher task for existence...
September 28, 2017: Microscopy
https://www.readbyqxmd.com/read/29036383/nigral-stress-induced-dopamine-release-in-clinical-high-risk-and-antipsychotic-na%C3%A3-ve-schizophrenia
#17
Huai-Hsuan Tseng, Jeremy J Watts, Michael Kiang, Ivonne Suridjan, Alan A Wilson, Sylvain Houle, Pablo M Rusjan, Romina Mizrahi
Background: Striatal dopamine (DA) synthesis capacity and release are elevated in schizophrenia (SCZ) and its putative prodrome, the clinical high risk (CHR) state. Striatal DA function results from the activity of midbrain DA neurons projecting mainly from the substantia nigra (SN). Elevated stress-induced DA release in SCZ and CHR was observed in the striatum; however, whether it is also elevated in the SN is unclear. The current study aims to determine whether nigral DA release in response to a validated stress task is altered in CHR and in antipsychotic-naïve SCZ...
June 13, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29036332/sensitivity-to-physical-activity-predicts-daily-activity-among-pain-free-older-adults
#18
Leah Miller, Thomas Ohlman, Kelly Marie Naugle
Objective: Prior research indicates that older adults with knee osteoarthritis have increased sensitivity to physical activity (SPA) and respond to physical activities of stable intensity with increases in pain. Whether SPA is present in healthy older adults without chronic pain and predicts functional outcomes remains relatively unexplored. The purpose of this study was to determine the degree of SPA in healthy older adults in response to a standardized walking task, and whether SPA was associated with temporal summation of pain, pain-related fear of movement, and functional outcomes...
October 4, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29036277/pyseqlab-an-open-source-python-package-for-sequence-labeling-and-segmentation
#19
Ahmed Allam, Michael Krauthammer
Motivation: Text and genomic data are composed of sequential tokens, such as words and nucleotides that give rise to higher order syntactic constructs. In this work, we aim at providing a comprehensive Python library implementing conditional random fields (CRFs), a class of probabilistic graphical models, for robust prediction of these constructs from sequential data. Results: Python Sequence Labeling (PySeqLab) is an open source package for performing supervised learning in structured prediction tasks...
July 21, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29036271/cancer-hallmarks-analytics-tool-chat-a-text-mining-approach-to-organize-and-evaluate-scientific-literature-on-cancer
#20
Simon Baker, Imran Ali, Ilona Silins, Sampo Pyysalo, Yufan Guo, Johan Högberg, Ulla Stenius, Anna Korhonen
Motivation: To understand the molecular mechanisms involved in cancer development, significant efforts are being invested in cancer research. This has resulted in millions of scientific articles. An efficient and thorough review of the existing literature is crucially important to drive new research. This time-demanding task can be supported by emerging computational approaches based on text mining which offer a great opportunity to organize and retrieve the desired information efficiently from sizable databases...
July 14, 2017: Bioinformatics
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