keyword
Keywords perinatal infection and develo...

perinatal infection and development outcome

https://read.qxmd.com/read/38485431/point-of-care-testing-and-treatment-of-sexually-transmitted-and-genital-infections-to-improve-birth-outcomes-in-high-burden-low-resource-settings-wantaim-a-pragmatic-cluster-randomised-crossover-trial-in-papua-new-guinea
#1
JOURNAL ARTICLE
Michaela A Riddell, Lisa M Vallely, Alice Mengi, Steven G Badman, Nicola Low, Handan Wand, John W Bolnga, Delly Babona, Glen D L Mola, Virginia Wiseman, Angela Kelly-Hanku, Caroline S E Homer, Christopher Morgan, Stanley Luchters, David M Whiley, Leanne J Robinson, Lucy Au, Irene Pukai-Gani, Moses Laman, Grace Kariwiga, Pamela J Toliman, Neha Batura, Sepehr N Tabrizi, Stephen J Rogerson, Suzanne M Garland, Rebecca J Guy, Rosanna W Peeling, William S Pomat, John M Kaldor, Andrew J B Vallely
BACKGROUND: Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, and bacterial vaginosis have been associated with adverse maternal and perinatal outcomes, but there is conflicting evidence on the benefits of antenatal screening and treatment for these conditions. We aimed to determine the effect of antenatal point-of-care testing and immediate treatment of C trachomatis, N gonorrhoeae, T vaginalis, and bacterial vaginosis on preterm birth, low birthweight, and other adverse maternal and perinatal outcomes compared with current standard of care, which included symptom-based treatment without laboratory confirmation...
April 2024: Lancet Global Health
https://read.qxmd.com/read/38466273/cost-effectiveness-of-strategies-for-treatment-timing-for-perinatally-acquired-hepatitis-c-virus
#2
JOURNAL ARTICLE
Megan Rose Curtis, Rachel L Epstein, Pamela Pei, Benjamin P Linas, Andrea L Ciaranello
IMPORTANCE: Prevalence of chronic hepatitis C virus (HCV) infection among pregnant people is increasing in the US. HCV is transmitted vertically in 7% to 8% of births. Direct-acting antiviral (DAA) therapy was recently approved for children with HCV who are 3 years or older. The clinical and economic impacts of early DAA therapy for young children with HCV, compared with treating at older ages, are unknown. OBJECTIVE: To develop a state-transition model to project clinical and economic outcomes for children with perinatally acquired HCV to investigate the cost-effectiveness of treating at various ages...
March 11, 2024: JAMA Pediatrics
https://read.qxmd.com/read/38454832/long-term-ocular-outcomes-in-congenital-toxoplasmosis-treated-perinatally
#3
JOURNAL ARTICLE
Antoine Journé, Justus Garweg, Eléa Ksiazek, François Peyron, Christine Binquet, Martine Wallon
BACKGROUND: Congenital toxoplasmosis (CT) can be accompanied by serious organ manifestations, particularly retinochoroiditis, and may occur throughout life. We aimed to monitor long-term ocular prognosis in a large French cohort of patients with CT and its changes over time in the context of mandatory prenatal screening (since 1992) and incidence decrease since 2008. METHODS: Patients with CT diagnosed between 1987 and 2021 were prospectively included and followed for up to 35 years...
March 8, 2024: Pediatrics
https://read.qxmd.com/read/38453249/maternal-and-perinatal-health-research-during-emerging-and-ongoing-epidemic-threats-a-landscape-analysis-and-expert-consultation
#4
JOURNAL ARTICLE
Mercedes Bonet, Magdalena Babinska, Pierre Buekens, Shivaprasad S Goudar, Beate Kampmann, Marian Knight, Dana Meaney-Delman, Smaragda Lamprianou, Flor Muñoz Rivas, Andy Stergachis, Cristiana M Toscano, Joycelyn Bhatia, Sarah Chamberlain, Usman Chaudhry, Jacqueline Mills, Emily Serazin, Hannah Short, Asher Steene, Michael Wahlen, Olufemi T Oladapo
INTRODUCTION: Pregnant women and their offspring are often at increased direct and indirect risks of adverse outcomes during epidemics and pandemics. A coordinated research response is paramount to ensure that this group is offered at least the same level of disease prevention, diagnosis, and care as the general population. We conducted a landscape analysis and held expert consultations to identify research efforts relevant to pregnant women affected by disease outbreaks, highlight gaps and challenges, and propose solutions to addressing them in a coordinated manner...
March 7, 2024: BMJ Global Health
https://read.qxmd.com/read/38421182/pathogenesis-of-viral-infections-during-pregnancy
#5
REVIEW
Patrick S Creisher, Sabra L Klein
SUMMARYViral infections during pregnancy are associated with significant adverse perinatal and fetal outcomes. Pregnancy is a unique immunologic and physiologic state, which can influence control of virus replication, severity of disease, and vertical transmission. The placenta is the organ of the maternal-fetal interface and provides defense against microbial infection while supporting the semi-allogeneic fetus via tolerogenic immune responses. Some viruses, such as cytomegalovirus, Zika virus, and rubella virus, can breach these defenses, directly infecting the fetus and having long-lasting consequences...
February 29, 2024: Clinical Microbiology Reviews
https://read.qxmd.com/read/38406047/paradoxical-and-unmasking-hiv-immune-reconstitution-inflammation-syndrome-in-antiretroviral-na%C3%A3-ve-pregnant-women-a-prospective-cohort-study
#6
JOURNAL ARTICLE
John K Muthuka, Everlyn M Nyamai, Kelly Oluoch, Charles Maibvise, Rosemary Nabaweesi
BACKGROUND AND AIMS: Following antiretroviral therapy (ART) initiation, HIV-associated immune reconstitution inflammatory syndrome (IRIS), indicated by an array of opportunistic infections, may occur, presenting as either paradoxical, a worsening of a previously treated infection, or unmasking, a flare-up of an underlying, previously undiagnosed infection. The impact of ART as the backbone of HIV treatment and prevention has prolonged the survival of people living with HIV. In pregnancy, benefits have been shown by slowing HIV progression and preventing perinatal transmission; however, there have been risks of adverse reactions with ART, including immune responses to both the fetus and mother...
January 2024: Curēus
https://read.qxmd.com/read/38392915/zika-virus-a-reemerging-neurotropic-arbovirus-associated-with-adverse-pregnancy-outcomes-and-neuropathogenesis
#7
REVIEW
Kenneth C Elliott, Joseph J Mattapallil
Zika virus (ZIKV) is a reemerging flavivirus that is primarily spread through bites from infected mosquitos. It was first discovered in 1947 in sentinel monkeys in Uganda and has since been the cause of several outbreaks, primarily in tropical and subtropical areas. Unlike earlier outbreaks, the 2015-2016 epidemic in Brazil was characterized by the emergence of neurovirulent strains of ZIKV strains that could be sexually and perinatally transmitted, leading to the Congenital Zika Syndrome (CZS) in newborns, and Guillain-Barre Syndrome (GBS) along with encephalitis and meningitis in adults...
February 15, 2024: Pathogens
https://read.qxmd.com/read/38385623/exploring-the-relationships-between-pathogen-specific-prenatal-infections-requiring-inpatient-admission-and-domains-of-offspring-behaviour-at-age-5
#8
JOURNAL ARTICLE
Kim Steven Betts, Steve Kisely, Rosa Alati
BACKGROUND: Research exploring the relationship between prenatal infection and child behavioural outcomes would benefit from further studies utilising full-population samples with the scale to investigate specific infections and to employ robust designs. We tested the association among several common infections requiring inpatient admission during and after pregnancy with a range of childhood behavioural outcomes, to determine whether any negative impact was specific to the period of foetal development...
February 22, 2024: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://read.qxmd.com/read/38381764/association-of-cesarean-section-and-infectious-outcomes-among-infants-at-1-year-of-age-logistic-regression-analysis-using-data-of-104-065-records-from-the-japan-environment-and-children-s-study
#9
JOURNAL ARTICLE
Hajime Maeda, Koichi Hashimoto, Hajime Iwasa, Hyo Kyozuka, Yohei Kume, Hayato Go, Akiko Sato, Yuka Ogata, Tsuyoshi Murata, Keiya Fujimori, Kosei Shinoki, Hidekazu Nishigori, Seiji Yasumura, Mitsuaki Hosoya
BACKGROUND: There has been a recent decrease in the prevalence of infectious diseases in children worldwide due to the usage of vaccines. However, the association between cesarean delivery and infectious diseases remains unclear. Here, we aimed to clarify the association between cesarean delivery and the development of infectious diseases. METHODS: This study is a cross-sectional study. We used data from the Japan Environment and Children's Study, which is a prospective, nationwide, government-funded birth cohort study...
2024: PloS One
https://read.qxmd.com/read/38378641/layered-vulnerability-and-researchers-responsibilities-learning-from-research-involving-kenyan-adolescents-living-with-perinatal-hiv-infection
#10
JOURNAL ARTICLE
Mary Kimani, Sassy Molyneux, Anderson Charo, Scholastica M Zakayo, Gladys Sanga, Rita Njeru, Alun Davies, Maureen Kelley, Amina Abubakar, Vicki Marsh
BACKGROUND: Carefully planned research is critical to developing policies and interventions that counter physical, psychological and social challenges faced by young people living with HIV/AIDS, without increasing burdens. Such studies, however, must navigate a 'vulnerability paradox', since including potentially vulnerable groups also risks unintentionally worsening their situation. Through embedded social science research, linked to a cohort study involving Adolescents Living with HIV/AIDS (ALH) in Kenya, we develop an account of researchers' responsibilities towards young people, incorporating concepts of vulnerability, resilience, and agency as 'interacting layers'...
February 20, 2024: BMC Medical Ethics
https://read.qxmd.com/read/38359341/late-neonatal-sepsis-in-very-low-weight-premature-newborns-is-associated-with-alterations-in-neurodevelopment-at-twenty-five-months-of-age
#11
JOURNAL ARTICLE
Jose Uberos, Ana Nieto-Ruiz, Francisco Contreras Chova, Marta Carrasco-Solis, Aida Ruiz-López, Elisabeth Fernandez-Marín, Carolina Laynez-Rubio, Ana Campos-Martinez
AIM: To evaluate the impact of late-onset sepsis (LOS) on the neurodevelopment of very-low-birth-weight (VLBW) premature infants. METHODS: This is a retrospective cohort study of VLBW premature infants. The Mental Development Index (MDI) was determined for a population of 546 VLBW infants, at 14 and 25 months of age, and evaluated using the Bayley test. A history of meningitis or early neonatal sepsis was considered an exclusion criterion. The study parameters analyzed included perinatal variables, the development of neonatal comorbidities and a history of LOS...
February 12, 2024: Pediatric Infectious Disease Journal
https://read.qxmd.com/read/38355934/arboviruses-and-pregnancy-are-the-threats-visible-or-hidden
#12
JOURNAL ARTICLE
Najeh Hcini, Véronique Lambert, Olivier Picone, Jean-Francois Carod, Gabriel Carles, Léo Pomar, Loïc Epelboin, Mathieu Nacher
Mosquito-borne arboviral diseases are a global concern and can have severe consequences on maternal, neonatal, and child health. Their impact on pregnancy tends to be neglected in developing countries. Despite hundreds of millions of infections, 90% pregnancies being exposed, scientific data on pregnant women is poor and sometimes non-existent. Recently and since the 2016 Zika virus outbreak, there has been a newfound interest in these diseases. Through various neuropathogenic, visceral, placental, and teratogenic mechanisms, these arbovirus infections can lead to fetal losses, obstetrical complications, and a wide range of congenital abnormalities, resulting in long-term neurological and sensory impairments...
February 15, 2024: Tropical Diseases, Travel Medicine and Vaccines
https://read.qxmd.com/read/38351549/cerebral-palsy-in-african-paediatric-populations-a-scoping-review
#13
REVIEW
Serini Murugasen, Priscilla Springer, Bolajoko O Olusanya, Melissa Gladstone, Charles Newton, Angelina Kakooza-Mwesige, Kirsten A Donald
AIM: To review the epidemiology and outcomes of African children with cerebral palsy (CP) over a 21-year period. METHOD: The PubMed, Scopus, and Web of Science online databases were searched for original research on African children with CP aged 18 years and younger published from 2000 to 2021. RESULTS: A total of 1811 articles underwent review against explicit criteria; 93 articles were selected for inclusion in the scoping review...
February 13, 2024: Developmental Medicine and Child Neurology
https://read.qxmd.com/read/38347174/genetic-susceptibility-for-retinopathy-of-prematurity-and-its-associated-comorbidities
#14
JOURNAL ARTICLE
Lucas G Gimenez, Juan A Gili, Darío E Elias, Rubén Sagula, Belén Comas, María R Santos, Hebe Campaña, Fernando A Poletta, Silvina L Heisecke, Julia Ratowiecki, Viviana R Cosentino, Rocío Uranga, César Saleme, Mercedes Negri, Mónica Rittler, Jorge Zapata Barrios, Hugo B Krupitzki, Jorge S López Camelo
BACKGROUND: Retinopathy of prematurity (ROP) is one of the leading cause of child blindness. Preterm newborns of very low gestational age (GA) and very low birth weight are at the greatest risk. Our objective was to evaluate the role of genetic variants associated with ROP risk and its comorbidities in an Argentinian sample of premature infants. METHODS: A sample of 437 preterm infants <33 weeks GA, born at a maternity hospital in Tucumán, Argentina, 2005-2010, was analyzed...
February 12, 2024: Pediatric Research
https://read.qxmd.com/read/38328227/maternal-n-3-enriched-diet-reprograms-neurovascular-transcriptome-and-blunts-inflammation-in-neonate
#15
Tetyana Chumak, Amandine Jullienne, C Joakim Ek, Maryam Ardalan, Pernilla Svedin, Ryan Quan, Arjang Salehi, Sirus Salari, Andre Obenaus, Zinaida S Vexler, Carina Mallard
Infection during perinatal period can adversely affect brain development, predispose infants to ischemic stroke and have lifelong consequences. We previously demonstrated that diet enriched in n-3 polyunsaturated fatty acids (PUFA) transforms brain lipid composition and protects from neonatal stroke. Vasculature is a critical interface between blood and brain providing a barrier to systemic infection. Here we examined whether maternal PUFA-enriched diets exert reprograming of endothelial cell signalling in 9-day old mice after endotoxin (LPS)-induced infection...
January 22, 2024: bioRxiv
https://read.qxmd.com/read/38301365/maternal-covid-19-infection-and-intrauterine-fetal-death-impact-on-the-placenta-and-fetus
#16
JOURNAL ARTICLE
Preethi Muthusamy Sundar, Umamaheswari Gurusamy, Lalitha Natarajan
BACKGROUND: Placental damage due to viral infections increases risk of adverse perinatal outcomes. Histopathologic examination of placenta can provide information regarding association between infection and outcome. There is paucity of data describing placental pathology with respect to intrauterine fetal death (IUFD) in pregnant mothers affected with COVID-19. METHODS: 4 fetuses and 10 placentas, including one twin placenta from 9 women with history of IUFD and SARS-CoV-2 infection underwent evaluation...
January 20, 2024: Pathology, Research and Practice
https://read.qxmd.com/read/38272538/adverse-perinatal-outcomes-in-gestational-diabetes-mellitus-with-and-without-sars-cov-2-infection-during-pregnancy-results-from-two-nationwide-registries-in-germany
#17
MULTICENTER STUDY
Tatjana P Liedtke, Katharina S Weber, Heinke Adamczewski, Dietmar Weber, Babett Ramsauer, Ute M Schaefer-Graf, Tanja Groten, Eike A Strathmann, Wolfgang Lieb, Mario Rüdiger, Ulrich Pecks, Helmut J Kleinwechter
INTRODUCTION: Pregnancy is a known independent risk factor for a severe course of COVID-19. The relationship of SARS-CoV-2 infection and gestational diabetes mellitus (GDM) on neonatal outcomes is unclear. Our aim was to determine if SARS-CoV-2 infection represents an independent risk factor for adverse perinatal outcomes in pregnancy with GDM. RESEARCH DESIGN AND METHODS: We compared data from two German registries including pregnant women with GDM, established during the SARS-CoV-2 pandemic (COVID-19-Related Obstetric and Neonatal Outcome Study (CRONOS), a multicenter prospective observational study) and already existing before the pandemic (German registry of pregnant women with GDM; GestDiab)...
January 25, 2024: BMJ Open Diabetes Research & Care
https://read.qxmd.com/read/38248844/the-urinary-metabolome-of-newborns-with-perinatal-complications
#18
JOURNAL ARTICLE
Yamilé López-Hernández, Victoria Lima-Rogel, Rupasri Mandal, Jiamin Zheng, Lun Zhang, Eponine Oler, David Alejandro García-López, Claudia Torres-Calzada, Ana Ruth Mejía-Elizondo, Jenna Poelsner, Jesús Adrián López, Ashley Zubkowski, David S Wishart
Maternal pathological conditions such as infections and chronic diseases, along with unexpected events during labor, can lead to life-threatening perinatal outcomes. These outcomes can have irreversible consequences throughout an individual's entire life. Urinary metabolomics can provide valuable insights into early physiological adaptations in healthy newborns, as well as metabolic disturbances in premature infants or infants with birth complications. In the present study, we measured 180 metabolites and metabolite ratios in the urine of 13 healthy (hospital-discharged) and 38 critically ill newborns (admitted to the neonatal intensive care unit (NICU))...
January 10, 2024: Metabolites
https://read.qxmd.com/read/38231512/prenatal-opioid-exposure-and-immune-related-conditions-in-children
#19
JOURNAL ARTICLE
Erin Kelty, Kaitlyn Rae, Lauren L Jantzie, Caitlin S Wyrwoll, David B Preen
IMPORTANCE: Prenatal opioid exposure (POE) may alter with fetal development of the immune system, which may influence long-term health and susceptibility to immune-related conditions. OBJECTIVE: To compare the risk of hospitalization and emergency department presentation for immune-related conditions in children with and without POE. DESIGN, SETTING, AND PARTICIPANTS: This retrospective, population-based cohort study used linked administrative health records of all children born in Western Australia between January 1, 2003, and December 31, 2018 (N = 401 462)...
January 2, 2024: JAMA Network Open
https://read.qxmd.com/read/38219600/combined-impact-of-hepatitis-b-virus-and-gestational-diabetes-mellitus-on-ultrasound-measured-fetal-growth-and-adverse-perinatal-outcomes-a-seven-year-retrospective-study
#20
JOURNAL ARTICLE
Yiming Tu, Yanting Li, Xiaoxiao Fan, Zaidi Gui, Jiamiao Dai, Qingbo Fang, Tianlai Qiu, Jinbing Bai, Yanqun Liu
AIMS: To investigate the impact of pregnancy with combined hepatitis B virus (HBV) infection and Gestational diabetes mellitus (GDM) on fetal growth and adverse perinatal outcomes. METHODS: All the pregnant women with HBV infection and/or GDM who delivered at Women's Hospital, Zhejiang University between January 2015, and September 2022 were included. A total of 1633 pregnant women were recruited in the final analysis, including 409 women with HBV infection and GDM, 396 with HBV infection only, 430 with GDM only, and 398 without HBV infection and GDM...
January 13, 2024: Diabetes Research and Clinical Practice
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