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https://www.readbyqxmd.com/read/29331346/predicting-low-resource-intensity-emergency-department-visits-in-children
#1
Margaret Samuels-Kalow, Alon Peltz, Jonathan Rodean, Matthew Hall, Elizabeth R Alpern, Paul L Aronson, Jay G Berry, Kathy N Shaw, Rustin B Morse, Stephen B Freedman, Eyal Cohen, Harold K Simon, Samir S Shah, Yiannis Katsogridakis, Mark I Neuman
BACKGROUND AND OBJECTIVES: Interventions to reduce frequent emergency department (ED) use in children are often limited by the inability to predict future risk. We sought to develop a population-based model for predicting Medicaid-insured children at risk for high frequency of low-resource intensity (LRI) ED visits. METHODS: Retrospective cohort analysis of Medicaid-insured children (age 1-18 years) included in the MarketScan® Medicaid database with ≥1 ED visit(s) in 2013...
January 10, 2018: Academic Pediatrics
https://www.readbyqxmd.com/read/29330930/gender-specific-risk-factors-for-androgenetic-alopecia-in-the-korean-general-population-associations-with-medical-comorbidities-and-general-health-behaviors
#2
Bo-Kyung Kim, Sung Jay Choe, Hee-Chul Chung, Sung-Soo Oh, Won-Soo Lee
BACKGROUND: The relationships between androgenetic alopecia (AGA) and various factors related to metabolic syndrome have been demonstrated in previous studies. However, it remains unclear because of inconsistent results. We investigated the associations between AGA and various risk factors related to metabolic syndrome according to gender. METHODS: We conducted a population-based cross-sectional survey of 2028 Koreans (1050 men, 978 women). The basic and specific (BASP) classification was used for diagnosis of AGA...
February 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29330680/the-illusion-of-control-sequential-dependencies-underlie-contingent-attentional-capture
#3
Greg Huffman, Victoria M Antinucci, Jay Pratt
The degree to which humans have top-down control over which information they process remains a central debate within the attention literature. Most of the evidence supporting the top-down control of visuospatial attention has come from cueing paradigms in which target stimuli are preceded by cues that are similar or dissimilar from the target. These studies find that the cues similar to targets capture attention, but dissimilar cues do not, suggesting the top-down control of attention. Here, we used a modified cueing paradigm to investigate an alternative possibility that the cue type differences are due to sequential dependency effects occurring between cue and target processing rather than the top-down control of attention...
January 12, 2018: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/29330236/antidepressants-and-incident-hypertension-in-primary-care-patients
#4
Matthew Breeden, Jay Brieler, Joanne Salas, Jeffrey F Scherrer
OBJECTIVE: Many ADMs can alter blood pressure (BP), but the research on the effect of antidepressant medication (ADMs) on incident hypertension is mixed. We investigated whether the use of ADMs was associated with the subsequent development of hypertension. METHODS: A retrospective cohort study was conducted using electronic medical record data from 6224 patients with primary care visits from 2008 to 2015. Prescription orders were used to identify ADM use, and hypertension was defined by medical record diagnosis...
January 2018: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/29329894/neoadjuvant-dose-dense-mvac-versus-gc-in-patients-with-ct3-4an0m0-bladder-cancer-treated-with-radical-cystectomy
#5
Homayoun Zargar, Jay B Shah, Bas W van Rhijn, Siamak Daneshmand, Trinity J Bivalacqua, Philippe E Spiess, Peter C Black, Wassim Kassouf
BACKGROUND: Level I evidence supports the utility of neoadjuvant cisplatin-based chemotherapy (NAC) for muscle invasive bladder cancer (BCa). Since dose dense (ddMVAC) has mostly replaced traditional MVAC, we aimed to compare pathological response and survival rates in patients with locally advanced BCa receiving NAC with ddMVAC versus GC. METHODS: We retrospectively reviewed records of patients with urothelial cancer who received NAC and underwent cystectomy at 20 contributing institutions from 2000-2015...
January 9, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29329796/the-evolving-face-of-myocardial-reperfusion-in-acute-coronary-syndromes-a-primer-for-the-internist
#6
REVIEW
R Jay Widmer, Peter M Pollak, Malcolm R Bell, Bernard J Gersh, Nandan S Anavekar
Acute coronary syndromes (ACSs) account for a large proportion of disease burden in the United States and worldwide, and our understanding of ACS management continues to evolve. In this review we take a practical approach to evaluating and treating a patient with ACS, focusing on the optimal timing and methods of coronary reperfusion. Beginning with initial assessment and risk stratification, a provider managing the patient with ACS must be able to expeditiously decide on and implement the correct guideline-directed pathway to optimize outcomes...
January 9, 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29329728/gene-expression-patterns-associated-with-human-placental-trophoblast-differentiation
#7
Shi-Wen Jiang, Wei Zhou, Jianhao Wang, Lauren M Little, Lynn Leaphart, Jacob Jay, Eseosaserea Igbinigie, Haibin Chen, Jinping Li
Cell fusion is a hallmark of placental trophoblast cell differentiation and the mature syncytiotrophoblasts play essential roles for fetal-maternal exchange and production of pregnancy-related hormones. Using a well-established in vitro trophoblast differentiation model, we performed a microarray analysis on mRNA expression in trophoblast and syncytiotrophoblast cell cultures. Dramatic changes in gene expression patterns were detected during trophoblast differentiation. Real-time PCR analysis confirmed the reliability of the microarray data...
January 9, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29329684/impact-of-seasonal-influenza-vaccination-in-the-presence-of-vaccine-interference
#8
Eunha Shim, Kenneth J Smith, Mary Patricia Nowalk, Jonathan M Raviotta, Shawn T Brown, Jay DePasse, Richard K Zimmerman
BACKGROUND: Annual influenza vaccination is a key to preventing widespread influenza infections. Recent reports of influenza vaccine effectiveness (VE) indicate that vaccination in prior years may reduce VE in the current season, suggesting vaccine interference. The purpose of this study is to evaluate the potential effect of repeat influenza vaccinations in the presence of vaccine interference. METHODS: Using literature-based parameters, an age-structured influenza equation-based transmission model was used to determine the optimal vaccination strategy, while considering the effect of varying levels of interference...
January 9, 2018: Vaccine
https://www.readbyqxmd.com/read/29329659/discovery-of-mcl-1-inhibitors-based-on-a-thiazolidine-2-4-dione-scaffold
#9
Ellis Whiting, Mithun R Raje, Jay Chauhan, Paul T Wilder, Daniel Van Eker, Samuel J Hughes, Nathan G Bowen, Gregory E A Vickers, Ian C Fenimore, Steven Fletcher
Inspired by a rhodanine-based dual inhibitor of Bcl-xL and Mcl-1, a focused library of analogues was prepared wherein the rhodanine core was replaced with a less promiscuous thiazolidine-2,4-dione scaffold. Compounds were initially evaluated for their abilities to inhibit Mcl-1. The most potent compound 12b inhibited Mcl-1 with a Ki of 155 nM. Further investigation revealed comparable inhibition of Bcl-xL (Ki = 90 nM), indicating that the dual inhibitory profile of the initial rhodanine lead had been retained upon switching the heterocycle core...
December 12, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29329135/clinician-perceptions-of-the-importance-of-the-components-of-hospital-discharge-care-for-children
#10
Kevin Blaine, Jayne Rogers, Margaret R OʼNeill, Sarah McBride, Jennifer Faerber, Chris Feudtner, Jay G Berry
BACKGROUND: Discharging hospitalized children involves several different components, but their relative value is unknown. We assessed which discharge components are perceived as most and least important by clinicians. METHODS: March and June of 2014, we conducted an online discrete choice experiment (DCE) among national societies representing 704 nursing, physician, case management, and social work professionals from 46 states. The DCE consisted of 14 discharge care components randomly presented two at a time for a total of 28 choice tasks...
April 11, 2017: Journal for Healthcare Quality: Official Publication of the National Association for Healthcare Quality
https://www.readbyqxmd.com/read/29328300/effects-of-edge-inclination-angles-on-whispering-gallery-modes-in-printable-wedge-microdisk-lasers
#11
Cong Chen, Lei Wan, Hengky Chandrahalim, Jian Zhou, Hui Zhang, Sangha Cho, Ting Mei, Hiroaki Yoshioka, Huiping Tian, Naoya Nishimura, Xudong Fan, L Jay Guo, Yuji Oki
The ink-jet technique was developed to print the wedge polymer microdisk lasers. The characterization of these lasers was implemented using a free-space optics measurement setup. It was found that disks of larger edge inclination angles have a larger free spectral range (FSR) and a lower resonance wavelength difference between the fundamental transverse electric (TE) and transverse magnetic (TM) whispering-gallery modes (WGMs). This behavior was also confirmed with simulations based on the modified Oxborrow's model with perfectly matched layers (PMLs), which was adopted to accurately calculate the eigenfrequencies, electric field distributions, and quality parameters of modes in the axisymmetric microdisk resonators...
January 8, 2018: Optics Express
https://www.readbyqxmd.com/read/29328237/visible-light-optical-coherence-microscopy-of-the-brain-with-isotropic-femtoliter-resolution-in-vivo
#12
Conrad William Merkle, Shau Poh Chong, Aaron Michael Kho, Jun Zhu, Alfredo Dubra, Vivek Jay Srinivasan
Most flying-spot optical coherence tomography and optical coherence microscopy (OCM) systems use a symmetric confocal geometry, where the detection path retraces the illumination path starting from and ending with the spatial mode of a single-mode optical fiber. Here we describe a visible light OCM instrument that breaks this symmetry to improve transverse resolution without sacrificing collection efficiency in scattering tissue. This was achieved by overfilling a water immersion objective on the illumination path while maintaining a conventional Gaussian mode detection path (1/e2 intensity diameter ∼0...
January 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/29325841/single-center-experience-with-venovenous-ecmo-for-influenza-related-ards
#13
Jessica Buchner, Michael Mazzeffi, Zachary Kon, Jay Menaker, Lewis Rubinson, Gregory Bittle, Chetan Pasrija, Daniel Herr
OBJECTIVES: This study was designed to determine whether venovenous extracorporeal membrane oxygenation (VV ECMO) reduced mortality in patients with influenza-related acute respiratory distress syndrome (ARDS). DESIGN: A retrospective cohort study was performed. Baseline characteristics of participants were compared and Kaplan-Meier survival analysis was used to compare survival at last medical center follow-up. Cox proportional hazards modeling also was performed to test for univariate associations between salient variables and mortality...
September 22, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29324565/assessment-of-child-lead-exposure-in-a-philadelphia-community-2014
#14
Timothy Dignam, Ana Pomales, Lora Werner, E Claire Newbern, James Hodge, Jay Nielsen, Aaron Grober, Karen Scruton, Rand Young, Jack Kelly, Mary Jean Brown
INTRODUCTION: Several urban neighborhoods in Philadelphia, Pennsylvania, have a history of soil, household lead paint, and potential lead-emitting industry contamination. OBJECTIVES: To (1) describe blood lead levels (BLLs) in target neighborhoods, (2) identify risk factors and sources of lead exposure, (3) describe household environmental lead levels, and (4) compare results with existing data. METHODS: A simple, random, cross-sectional sampling strategy was used to enroll children 8 years or younger living in selected Philadelphia neighborhoods with a history of lead-emitting industry during July 2014...
January 10, 2018: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/29324547/stereotactic-body-radiation-therapy-intensity-modulated-radiation-therapy-and-brachytherapy-boost-modalities-in-invasive-cervical-cancer-a-study-of-the-national-cancer-data-base
#15
Barrett OʼDonnell, Jay C Shiao, Todd A Pezzi, Nabila Waheed, Shelly Sharma, Mark D Bonnen, Michelle S Ludwig
BACKGROUND AND PURPOSE: Our objective was to determine whether stereotactic body radiotherapy (SBRT), intensity-modulated radiation therapy (IMRT), and brachytherapy boost techniques have comparable overall survival in treating cervical cancer when adjusted for known prognostic factors. MATERIALS AND METHODS: We used the National Cancer Database to study women with invasive cervical cancer who were treated with radiation between 2004 and 2013. A logistic regression model was built to identify factors associated with the receipt of SBRT and IMRT...
January 10, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29324501/nonpharmacologic-management-of-acute-singultus-hiccups
#16
Daniel S Orlovich, Jay B Brodsky, John G Brock-Utne
No abstract text is available yet for this article.
January 9, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29323839/alcohol-use-increasing-among-adults-65-and-older
#17
Jon Glover, Jay A Gold
No abstract text is available yet for this article.
August 2017: WMJ: Official Publication of the State Medical Society of Wisconsin
https://www.readbyqxmd.com/read/29323827/understanding-the-medicare-quality-payment-program
#18
Christopher Becker, Jay A Gold
No abstract text is available yet for this article.
June 2017: WMJ: Official Publication of the State Medical Society of Wisconsin
https://www.readbyqxmd.com/read/29323639/the-polio-endgame-securing-a-world-free-of-all-polioviruses
#19
Michel Zaffran, Michael McGovern, Reza Hossaini, Rebecca Martin, Jay Wenger
No abstract text is available yet for this article.
January 6, 2018: Lancet
https://www.readbyqxmd.com/read/29321888/a-general-modeling-framework-for-describing-spatially-structured-population-dynamics
#20
Christine Sample, John M Fryxell, Joanna A Bieri, Paula Federico, Julia E Earl, Ruscena Wiederholt, Brady J Mattsson, D T Tyler Flockhart, Sam Nicol, Jay E Diffendorfer, Wayne E Thogmartin, Richard A Erickson, D Ryan Norris
Variation in movement across time and space fundamentally shapes the abundance and distribution of populations. Although a variety of approaches model structured population dynamics, they are limited to specific types of spatially structured populations and lack a unifying framework. Here, we propose a unified network-based framework sufficiently novel in its flexibility to capture a wide variety of spatiotemporal processes including metapopulations and a range of migratory patterns. It can accommodate different kinds of age structures, forms of population growth, dispersal, nomadism and migration, and alternative life-history strategies...
January 2018: Ecology and Evolution
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