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https://www.readbyqxmd.com/read/28440931/microplastics-as-vectors-for-environmental-contaminants-exploring-sorption-desorption-and-transfer-to-biota
#1
Nanna B Hartmann, Sinja Rist, Julia Bodin, Louise Hs Jensen, Stine N Schmidt, Philipp Mayer, Anders Meibom, Anders Baun
The occurrence and effects of microplastics (MPs) in the aquatic environment are receiving increasing attention. In addition to their possible direct adverse effects on biota, the potential role of MPs as vectors for hydrophobic organic chemicals (HOCs), compared to natural pathways, is a topic of much debate. It is evident, however, that temporal and spatial variations of MP occurrence do (and will) occur. To further improve the estimations of the role of MPs as vectors for HOC transfer into biota under varying MP concentrations and environmental conditions, it is important to identify and understand the governing processes...
May 2017: Integrated Environmental Assessment and Management
https://www.readbyqxmd.com/read/28440640/nucleic-acid-nanocapsules-for-enzyme-triggered-drug-release
#2
Joseph K Awino, Saketh Gudipati, Alyssa K Hartmann, Joshua J Santiana, Dominic F Cairns-Gibson, Nicole Gomez, Jessica L Rouge
Herein we describe a nucleic acid functionalized nanocapsule in which nucleic acid ligands are assembled and disassembled in the presence of enzymes. The particles are fully degradable in response to esterases due to an embedded ester cross-linker in the particle's core. During synthesis the nanocapsules can be loaded with hydrophobic small molecules and post self-assembly undergo covalent cross-linking using copper catalyzed click chemistry. They can then be functionalized with thiolated DNA through stepwise thiolyne chemistry using UV light irradiation...
April 25, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28438888/accessibility-availability-and-potential-benefits-of-psycho-oncology-services-the-perspective-of-community-based-physicians-providing-cancer-survivorship-care
#3
Verena Zimmermann-Schlegel, Mechthild Hartmann, Halina Sklenarova, Wolfgang Herzog, Markus W Haun
BACKGROUND: As persons of trust, community-based physicians providing survivorship care (e.g., general practitioners [GPs]) often serve as the primary contacts for cancer survivors disclosing distress. From the perspective of physicians providing survivorship care for cancer patients, this study explores (a) the accessibility, availability, and potential benefits of psycho-oncology services; (b) whether physicians themselves provide psychosocial support; and (c) predictors for impeded referrals of survivors to services...
April 24, 2017: Oncologist
https://www.readbyqxmd.com/read/28438422/next-generation-parasitologists-structured-training-programs-meet-educational-challenges
#4
Juliane Kofer, Heribert Hofer, Susanne Hartmann
Parasite infections are diverse, complex and widespread, and they represent major health threats to people and animals alike. Topics such as vaccine development, drug resistance, immune regulation, vector-borne parasitic diseases, and wildlife parasitology are key issues. Here, we discuss the need and direction of structured educational programs for graduates in modern parasitology.
April 21, 2017: Trends in Parasitology
https://www.readbyqxmd.com/read/28438088/anaplasma-ehrlichia-and-rickettsia-species-infections-in-cats
#5
Maria Grazia Pennisi, Regina Hofmann-Lehmann, Alan D Radford, Séverine Tasker, Sándor Belák, Diane D Addie, Corine Boucraut-Baralon, Herman Egberink, Tadeusz Frymus, Tim Gruffydd-Jones, Katrin Hartmann, Marian C Horzinek, Margaret J Hosie, Albert Lloret, Hans Lutz, Fulvio Marsilio, Etienne Thiry, Uwe Truyen, Karin Möstl
Anaplasma species, Ehrlichia species and Rickettsia species are vector-borne pathogens infecting a wide variety of mammals, but causing disease in very few of them. Infection in cats: Anaplasma phagocytophilum is the most important feline pathogen among these rickettsial organisms, and coinfections are possible. Little information is available on the pathogenesis of these agents in cats. Clinical signs are usually reported soon after tick infestation. They are mostly non-specific, consisting of fever, anorexia and lethargy...
May 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28437951/hot-spot-relaxation-time-current-dependence-in-niobium-nitride-waveguide-integrated-superconducting-nanowire-single-photon-detectors
#6
Simone Ferrari, Vadim Kovalyuk, Wladislaw Hartmann, Andreas Vetter, Oliver Kahl, Changhyoup Lee, Alexander Korneev, Carsten Rockstuhl, Gregory Gol'tsman, Wolfram Pernice
We investigate how the bias current affects the hot-spot relaxation dynamics in niobium nitride. We use for this purpose a near-infrared pump-probe technique on a waveguide-integrated superconducting nanowire single-photon detector driven in the two-photon regime. We observe a strong increase in the picosecond relaxation time for higher bias currents. A minimum relaxation time of (22 ± 1) ps is obtained when applying a bias current of 50% of the switching current at 1.7 K bath temperature. We also propose a practical approach to accurately estimate the photon detection regimes based on the reconstruction of the measured detector tomography at different bias currents and for different illumination conditions...
April 17, 2017: Optics Express
https://www.readbyqxmd.com/read/28436117/early-introduction-of-oral-paricalcitol-in-renal-transplant-recipients-an-open-label-randomized-study
#7
Hege Kampen Pihlstrøm, Franscesca Gatti, Clara Hammarström, Ivar Anders Eide, Monika Kasprzycka, Junbai Wang, Guttorm Haraldsen, My Hanna Sofia Svensson, Karsten Midtvedt, Geir Mjøen, Dag Olav Dahle, Anders Hartmann, Hallvard Holdaas
In stable renal transplant recipients with hyperparathyroidism, previous studies have indicated that vitamin D agonist treatment might have anti-proteinuric effects. Animal studies indicate possible anti-fibrotic and anti-inflammatory effects. Early introduction of paricalcitol in de-novo renal transplant recipients might reduce proteinuria and prevent progressive allograft fibrosis. We performed a single-centre, prospective, randomized, open-label trial investigating effects of paricalcitol 2μg/day added to standard care...
April 24, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28435767/green-toxicology-a-strategy-for-sustainable-chemical-and-material-development
#8
EDITORIAL
Sarah E Crawford, Thomas Hartung, Henner Hollert, Björn Mathes, Bennard van Ravenzwaay, Thomas Steger-Hartmann, Christoph Studer, Harald F Krug
Green Toxicology refers to the application of predictive toxicology in the sustainable development and production of new less harmful materials and chemicals, subsequently reducing waste and exposure. Built upon the foundation of "Green Chemistry" and "Green Engineering", "Green Toxicology" aims to shape future manufacturing processes and safe synthesis of chemicals in terms of environmental and human health impacts. Being an integral part of Green Chemistry, the principles of Green Toxicology amplify the role of health-related aspects for the benefit of consumers and the environment, in addition to being economical for manufacturing companies...
2017: Environmental Sciences Europe
https://www.readbyqxmd.com/read/28434893/what-makes-people-leave-their-food-the-interaction-of-personal-and-situational-factors-leading-to-plate-leftovers-in-canteens
#9
Bettina Anne-Sophie Lorenz, Monika Hartmann, Nina Langen
In order to provide a basis for the reduction of food losses, our study analyzes individual food choice, eating and leftover behavior in a university canteen by consideration of personal, social and environmental determinants. Based on an extended literature review, a structural equation model is derived and empirically tested for a sample of 343 students. The empirical estimates support the derived model with a good overall model fit and sufficient R(2) values for dependent variables. Hence, our results provide evidence for a general significant impact of behavioral intention and related personal and social determinants as well as for the relevance of environmental/situational determinants such as portion sizes and palatability of food for plate leftovers...
April 20, 2017: Appetite
https://www.readbyqxmd.com/read/28432616/prognostic-impact-of-pd-1-and-its-ligands-in-renal-cell-carcinoma
#10
REVIEW
Franziska Erlmeier, Wilko Weichert, Andres Jan Schrader, Michael Autenrieth, Arndt Hartmann, Sandra Steffens, Philipp Ivanyi
Programmed death-1 receptor (PD-1) and programmed death-1 receptor-ligand (PD-L1) have been suggested to play a role as prognostic markers in clear cell renal cell carcinoma (ccRCC). The association between PD-L1 and prognosis seems to be more robust than for PD-1. Further, preliminary analyses suggest that neither PD-1 nor its ligands play a role as prognostic markers in non-clear cell RCC, while the prognostic role of PD-L2 in ccRCC as well as in non-clear cell RCC remains unclear.
June 2017: Medical Oncology
https://www.readbyqxmd.com/read/28430999/repurposing-quantiferon-for-detection-of-neutralizing-ifn-%C3%AE-autoantibodies-in-patients-with-nontuberculous-mycobacterial-infections
#11
Isabelle Suárez, Clara Lehmann, Henning Gruell, Jessica Graeb, Matthias Kochanek, Gerd Fätkenheuer, Georg Plum, Annelies van Wengen, Esther van de Vosse, Pia Hartmann, Leif G Hanitsch, Jan Rybniker
Nontuberculous mycobacterial (NTM) infections due to autoantibodies targeting IFN-γ are an emerging medical problem. However, case finding is hampered due to highly complex diagnostic procedures not available in routine laboratories. We show that QuantiFERON assays can be exploited as a simple screening tool that may facilitate adequate and timely treatment.
April 20, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28430247/precise-calibration-of-pupil-images-in-pyramid-wavefront-sensor
#12
Yong Liu, Quanquan Mu, Zhaoliang Cao, Lifa Hu, Chengliang Yang, Li Xuan
The pyramid wavefront sensor (PWFS) is a novel wavefront sensor with several inspiring advantages compared with Shack-Hartmann wavefront sensors. The PWFS uses four pupil images to calculate the local tilt of the incoming wavefront. Pupil images are conjugated with a telescope pupil so that each pixel in the pupil image is diffraction-limited by the telescope pupil diameter, thus the sensing error of the PWFS is much lower than that of the Shack-Hartmann sensor and is related to the extraction and alignment accuracy of pupil images...
April 20, 2017: Applied Optics
https://www.readbyqxmd.com/read/28427263/laser-induced-functionalization-of-organo-carbon-interfaces-for-selective-adsorption-of-au-nanoparticles-in-micro-sized-domains
#13
Martin Schade, Steffen Franzka, Nils Hartmann
Laser microprocessing of highly oriented pyrolytic graphite (HOPG) in conjunction with chemical functionalization routines are used to fabricate functional micro-sized domains. Infrared and Auger electron spectroscopy, contact angle measurements and electron microscopy are used for characterization of laser-fabricated structures. HOPG samples are coated with alkylsiloxane monolayers. Laser-induced bromination of coated HOPG samples in gaseous bromine is carried out using a microfocused laser beam at a wavelength of 514 nm and 1/e2 laser spot diameter of about 3 µm...
April 21, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28426351/chromosome-4-in-drosophila-melanogaster-imperfection-or-interesting-exception
#14
Michaelyn A Hartmann, Jeff Sekelsky
Drosophila melanogaster chromosome 4 is an anomaly because of its small size, chromatin structure, and most notably its lack of crossing over during meiosis. Earlier ideas about the absence of crossovers on 4 hypothesize that these unique characteristics function to prevent crossovers. Here, we explore hypotheses about the absence of crossovers on 4, how these have been addressed, and new insights into the mechanism behind this suppression. We review recently published results that indicate that global crossover patterning, in particular the centromere effect, make a major contribution to the prevention of crossovers on 4...
April 20, 2017: Fly
https://www.readbyqxmd.com/read/28426069/gradual-modification-of-ito-particle-s-crystal-structure-and-optical-properties-by-pulsed-uv-laser-irradiation-in-a-free-liquid-jet
#15
Marcus Lau, Thomas Straube, A Vikas Aggarwal, Ulrich Hagemann, Bernardo de Oliveira Viestel, Nils Hartmann, Torsten Textor, Harald Lutz, Jochen S Gutmann, Stephan Barcikowski
Indium tin oxide (ITO) particle coatings are known for high transparency in the visible, good conductive properties and near-infrared absorption. These properties depend on ITO particle's stoichiometric composition, defects and size. Here we present a method to gradually change ITO particle's optical properties by a simple and controlled laser irradiation process. The defined irradiation process and controlled energy dose input allows one to engineer the absorption and transmission of coatings made from these particles...
April 20, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28422960/predicting-the-impact-of-lynch-syndrome-causing-missense-mutations-from-structural-calculations
#16
Sofie V Nielsen, Amelie Stein, Alexander B Dinitzen, Elena Papaleo, Michael H Tatham, Esben G Poulsen, Maher M Kassem, Lene J Rasmussen, Kresten Lindorff-Larsen, Rasmus Hartmann-Petersen
Accurate methods to assess the pathogenicity of mutations are needed to fully leverage the possibilities of genome sequencing in diagnosis. Current data-driven and bioinformatics approaches are, however, limited by the large number of new variations found in each newly sequenced genome, and often do not provide direct mechanistic insight. Here we demonstrate, for the first time, that saturation mutagenesis, biophysical modeling and co-variation analysis, performed in silico, can predict the abundance, metabolic stability, and function of proteins inside living cells...
April 19, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28422519/spontaneous-hedonic-reactions-to-social-media-cues
#17
Guido M van Koningsbruggen, Tilo Hartmann, Allison Eden, Harm Veling
Why is it so difficult to resist the desire to use social media? One possibility is that frequent social media users possess strong and spontaneous hedonic reactions to social media cues, which, in turn, makes it difficult to resist social media temptations. In two studies (total N = 200), we investigated less-frequent and frequent social media users' spontaneous hedonic reactions to social media cues using the Affect Misattribution Procedure-an implicit measure of affective reactions. Results demonstrated that frequent social media users showed more favorable affective reactions in response to social media (vs...
April 19, 2017: Cyberpsychology, Behavior and Social Networking
https://www.readbyqxmd.com/read/28420649/a-sandwich-elisa-for-measurement-of-the-primary-glucagon-like-peptide-1-metabolite
#18
Nicolai J Wewer Albrechtsen, Ali Asmar, Frederik Jensen, Signe Törang, Lene Simonsen, Rune E Kuhre, Meena Asmar, Simon Veedfald, Astrid Plamboeck, Filip K Knop, Tina Vilsboll, Sten Madsbad, Michael A Nauck, Carolyn F Deacon, Jens Bulow, Jens J Holst, Bolette Hartmann
Glucagon-like peptide-1 (GLP-1) is an incretin hormone secreted from the gastrointestinal tract. It is best known for its glucose-dependent insulinotropic effects GLP-1 is secreted in its intact (active) form (7-36NH2) but is rapidly degraded by the dipeptidyl peptidase 4 (DPP-4) enzyme, converting >90% to the primary metabolite (9-36NH2) before reaching the targets via the circulation. Although originally thought to be inactive or antagonistic, GLP-1 9-36NH2 may have independent actions, and it is therefore relevant to be able to measure it...
April 18, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28419759/regulation-of-burkholderia%C3%A2-cenocepacia-biofilm-formation-by-rpon-and-the-c-di-gmp-effector-berb
#19
Mustafa Fazli, Morten Rybtke, Elisabeth Steiner, Elisabeth Weidel, Jens Berthelsen, Julie Groizeleau, Wu Bin, Boo Zhao Zhi, Zhang Yaming, Volkhard Kaever, Michael Givskov, Rolf W Hartmann, Leo Eberl, Tim Tolker-Nielsen
Knowledge about the molecular mechanisms that are involved in the regulation of biofilm formation is essential for the development of biofilm-control measures. It is well established that the nucleotide second messenger cyclic diguanosine monophosphate (c-di-GMP) is a positive regulator of biofilm formation in many bacteria, but more knowledge about c-di-GMP effectors is needed. We provide evidence that c-di-GMP, the alternative sigma factor RpoN (σ54), and the enhancer-binding protein BerB play a role in biofilm formation of Burkholderia cenocepacia by regulating the production of a biofilm-stabilizing exopolysaccharide...
April 16, 2017: MicrobiologyOpen
https://www.readbyqxmd.com/read/28419539/pd-l1-expression-in-extrahepatic-cholangiocarcinoma
#20
Dirk Walter, Eva Herrmann, Andreas Schnitzbauer, Stefan Zeuzem, Martin Leo Hansmann, Jan Peveling-Oberhag, Sylvia Hartmann
AIMS: To investigate expression of programmed cell death 1 (PD-1) receptor / programmed cell death ligand 1 (PD-L1) pathway as well as clinicopathological characteristics in extrahepatic cholangiocarcinoma (eCCA). METHODS: Tissue samples from patients with eCCA (n=69; perihilar CCA=40, distal CCA=29), who underwent surgical resection in the period from 2007 to 2015 were evaluated for PD-1, PD-L1, CD3 and CD163 expression and correlation with clinicopathological characteristics, including survival data, was performed...
April 17, 2017: Histopathology
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