keyword
MENU ▼
Read by QxMD icon Read
search

gut microflora

keyword
https://www.readbyqxmd.com/read/29345975/nano-and-micro-particles-for-delivery-of-catechins-physical-and-biological-performance
#1
Jian-Hui Ye, Mary Ann Augustin
Catechins, present in many fruits and vegetables, have many health benefits, but they are prone to degradation. Nano- and micro-particle systems have been used to stabilise catechins when exposed to adverse environments and to improve their bioavailability after ingestion. This review discusses the inherent properties of various catechins, the design of delivery formulations and the properties of catechin-loaded nano- and micro-particles. The protection afforded to catechins during exposure to harsh environmental conditions and gastrointestinal tract transit is reviewed...
January 18, 2018: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29320746/sada-expressing-staphylococci-in-the-human-gut-show-increased-cell-adherence-and-internalization
#2
Arif Luqman, Mulugeta Nega, Minh-Thu Nguyen, Patrick Ebner, Friedrich Götz
A subgroup of biogenic amines, the so-called trace amines (TAs), are produced by mammals and bacteria and can act as neuromodulators. In the genus Staphylococcus, certain species are capable of producing TAs through the activity of staphylococcal aromatic amino acid decarboxylase (SadA). SadA decarboxylates aromatic amino acids to produce TAs, as well as dihydroxy phenylalanine and 5-hydroxytryptophan to thus produce the neurotransmitters dopamine and serotonin. SadA-expressing staphylococci were prevalent in the gut of most probands, where they are part of the human intestinal microflora...
January 9, 2018: Cell Reports
https://www.readbyqxmd.com/read/29285295/nmr-based-metabolomic-techniques-identify-potential-urinary-biomarkers-for-early-colorectal-cancer-detection
#3
Zhening Wang, Yan Lin, Jiahao Liang, Yao Huang, Changchun Ma, Xingmu Liu, Jurong Yang
Better early detection methods are needed to improve the outcomes of patients with colorectal cancer (CRC). Proton nuclear magnetic resonance spectroscopy (1H-NMR), a potential non-invasive early tumor detection method, was used to profile urine metabolites from 55 CRC patients and 40 healthy controls (HCs). Pattern recognition through orthogonal partial least squares-discriminant analysis (OPLS-DA) was applied to 1H-NMR processed data. Model specificity was confirmed by comparison with esophageal cancers (EC, n=18)...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29276981/comparative-metabolism-of-two-major-compounds-in-fructus-corni-extracts-by-gut-microflora-from-normal-and-chronic-nephropathy-rats-in-vitro-by-uplc-q-tof-ms
#4
Jin-Hua Tao, Min Zhao, Shu Jiang, Xue-Lian Pu, Xiao-Yan Wei
Herbal medicines are widely used as therapeutic products in many countries. Fructus Corni, a traditional herb medicine, has been clinically used to cure chronic nephropathy for thousands of years. It could be converted by gut microflora in vivo to shape its pharmacological profiles. Thus, metabolic profiles of major active constituents in Fructus Corni extracts by gut microflora from rats in healthy and nephropathy state were firstly investigated in vitro by ultraperformance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) in this study...
December 18, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29250860/effect-of-organic-acids-or-probiotics-alone-or-in-combination-on-growth-performance-nutrient-digestibility-enzyme-activities-intestinal-morphology-and-gut-microflora-in-broiler-chickens
#5
P Rodjan, K Soisuwan, K Thongprajukaew, Y Theapparat, S Khongthong, J Jeenkeawpieam, T Salaeharae
A feeding trial was conducted to determine the effect of organic acids or probiotics alone or in combination on growth performance, nutrient digestibility, enzyme activity, intestinal morphology and gut microflora in broiler chickens (Ross308). A completely randomized design was used, with 1,440 broiler chicks across four treatments and five replications of 72 chicks each. The chicks in the control treatment were fed on a control diet (CD), whereas for the other treatment groups, the CD was supplemented with 0...
December 17, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29243150/characterization-of-multiple-antibiotic-resistance-of-culturable-microorganisms-and-metagenomic-analysis-of-total-microbial-diversity-of-marine-fish-sold-in-retail-shops-in-mumbai-india
#6
Onkar A Naik, Ravindranath Shashidhar, Devashish Rath, Jayant R Bandekar, Archana Rath
Marine fish species were analyzed for culturable and total metagenomic microbial diversity, antibiotic resistance (AR) pattern, and horizontal gene transfer in culturable microorganisms. We observed a high AR microbial load of 3 to 4 log CFU g-1. Many fish pathogens like Providencia, Staphylococcus, Klebsiella pneumoniae, Enterobacter, Vagococcus, and Aeromonas veronii were isolated. Photobacterium and Vibrio were two major fish and human pathogens which were identified in the fish metagenome. Other pathogens that were identified were Shewanella, Acinetobacter, Psychrobacter, and Flavobacterium...
December 14, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29230210/checkpoint-blockade-toxicity-and-immune-homeostasis-in-the-gastrointestinal-tract
#7
REVIEW
Michael Dougan
Monoclonal antibodies targeting the regulatory immune "checkpoint" receptors CTLA-4, PD-1, and PD-L1 are now standard therapy for diverse malignancies including melanoma, lung cancer, and renal cell carcinoma. Although effective in many patients and able to induce cures in some, targeting these regulatory pathways has led to a new class of immune-related adverse events. In many respects, these immune toxicities resemble idiopathic autoimmune diseases, such as inflammatory bowel disease, autoimmune hepatitis, rheumatoid arthritis, and vitiligo...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29229735/oral-application-of-recombinant-bacillus-subtilis-spores-to-dogs-results-in-a-humoral-response-against-specific-echinococcus-granulosus-paramyosin-and-tropomyosin-antigens
#8
Cédric M Vogt, Maria Teresa Armúa-Fernández, Kurt Tobler, Monika Hilbe, Claudio Aguilar, Mathias Ackermann, Peter Deplazes, Catherine Eichwald
Bacillus subtilis is known as an endospore- and biofilm-forming bacterium with probiotic properties. We have recently developed a method for displaying heterologous proteins on the surface of B. subtilis biofilms by introducing the coding sequences of the protein of interest into the bacterial genome to generate a fusion protein linked to the C-terminus of the biofilm matrix protein TasA. Although B. subtilis is a regular component of the gut microflora, we constructed a series of recombinant B. subtilis strains that were tested for their ability to immunize dogs following oral application of the spores...
December 11, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/29208562/microbiological-factors-affecting-clostridium-difficile-recurrence
#9
REVIEW
C H Chilton, D S Pickering, J Freeman
BACKGROUND: Recurrent Clostridium difficile infection (rCDI) places a huge economic and practical burden on healthcare facilities. Furthermore, rCDI may impact quality of life, leaving patients in a 'rCDI cycle', and dependant on antibiotic therapy. AIMS: This article discusses the importance of microbiological factors in the development of rCDI. SOURCES: Literature was drawn from a search of PubMed from 2000 onwards with the search term "recurrent Clostridium difficile infection"; and further references quoted within these articles...
December 2, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29207065/estrogen-inhibits-the-overgrowth-of-escherichia%C3%A2-coli-in-the-rat-intestine-under-simulated-microgravity
#10
Yongtao Yang, Changmin Qu, Shuwen Liang, Gang Wang, Haolun Han, Na Chen, Xiaoying Wang, Zhiwen Luo, Changqing Zhong, Yan Chen, Lianyong Li, Wei Wu
Microgravity can affect many aspects of intestinal homeostasis, leading to an increased risk of colitis. Estrogen, the most frequently affected hormone when under simulated microgravity, regulates the permeability of the colonic mucosa barrier. The associations between alterations in intestinal microbiota and increased susceptibility under microgravity have not been thoroughly elucidated. The aim of the present study was to evaluate the changes in intestinal microbiota under simulated microgravity and to investigate the protective effect of estrogen against those changes...
November 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29197739/a-meta-analysis-of-the-use-of-probiotics-to-alleviate-depressive-symptoms
#11
REVIEW
Qin Xiang Ng, Christina Peters, Collin Yih Xian Ho, Donovan Yutong Lim, Wee-Song Yeo
INTRODUCTION: Some preclinical and clinical studies have demonstrated the positive impact of probiotic supplementation on depressive symptoms. This paper aims to provide an updated meta-analysis on the topic. METHODS: Using the keywords [probiotics OR gut OR microflora OR microbiome OR bacteria OR yeast OR yoghurt OR lactobacillus OR bifidobacterium] AND [mood OR depression OR MDD OR suicide], a preliminary search on the PubMed, Ovid, Clinical Trials Register of the Cochrane Collaboration Depression, Anxiety and Neurosis Group (CCDANTR) and Cochrane Field for Complementary Medicine database yielded 917 papers published in English between 1-Jan-1960 and 1-June-2017...
November 16, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29191622/interplay-between-behavior-morphology-and-physiology-supports-lepidophagy-in-the-catfish-pachypterus-khavalchor-siluriformes-horabagridae
#12
Sachin M Gosavi, Sanjay S Kharat, Pradeep Kumkar, Sushant S Navarange
The present study demonstrates the scale-eating behavior of a siluroid catfish, Pachypterus khavalchor, and the role of its oral structure and bacterial endosymbionts in shaping this lepidophagous habit. Scale-eating behavior in P. khavalchor was studied using a series of behavioral experiments. P. khavalchor was found to feed only on the scales of live fish and never of dead fish, even after 72h of starvation. It was nocturnal in habit and attacked all species that were used as prey. Attacking behavior showed extensive chasing of prey species followed by a powerful random strike at the flank or close to the caudal region in posterior oblique position...
July 12, 2017: Zoology: Analysis of Complex Systems, ZACS
https://www.readbyqxmd.com/read/29186317/computational-profiling-of-the-gut-brain-axis-microflora-dysbiosis-insights-to-neurological-disorders
#13
Nikolas Dovrolis, George Kolios, George M Spyrou, Ioanna Maroulakou
Almost 2500 years after Hippocrates' observations on health and its direct association to the gastrointestinal tract, a paradigm shift has recently occurred, making the gut and its symbionts (bacteria, fungi, archaea and viruses) a point of convergence for studies. It is nowadays well established that the gut microflora's compositional diversity regulates via its genes (the microbiome) the host's health and provides preliminary insights into disease progression and regulation. The microbiome's involvement is evident in immunological and physiological studies that link changes in its biodiversity to its contributions to the host's phenotype but also in neurological investigations, substantiating the aptly named gut-brain axis...
November 27, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/29178568/hypoxia-induced-intestinal-barrier-changes-in-balloon-assisted-enteroscopy
#14
Tsung-Chun Lee, Yi-Chen Huang, Yen-Zhen Lu, Yu-Chang Yeh, Linda Chia-Hui Yu
Balloon-assisted enteroscopy (BAE) is an emerging standard procedure by utilizing distensible balloons to facilitate deep endoscopy. Intestines are known to harbor abundant microflora. Whether balloon distension causes perturbation of blood flow and gut barrier dysfunction, and elicits risk of bacterial translocation remains unknown. Our aims were to 1) conduct a prospective study to gather microbiological and molecular evidence of bacterial translocation by BAE in patients, 2) establish a murine model of colonic balloon distension to investigate tissue hypoxia and intestinal barrier, and 3) assess the effect of short- and long-term hypoxia on epithelial permeability using cell lines...
November 27, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29171643/nutritional-supplements-in-psychotic-disorders
#15
Vicent Balanzá Martínez
There is growing interest about the potential of diet and nutrients to improve the mental health of the population and for the treatment of psychiatric disorders. In the case of schizophrenia, the limitations of antipsychotic drugs to achieve adequate rates of clinical remission and functional recovery have promoted the search for complementary approaches. This narrative review approaches the dietary patterns and interventions in schizophrenia, efficacy of specific nutrients and therapeutic modulation of the gut microflora by probiotics...
September 2017: Actas Españolas de Psiquiatría
https://www.readbyqxmd.com/read/29169816/existing-and-investigational-therapies-for-the-treatment-of-clostridium-difficile-infection-a-focus-on-narrow-spectrum-microbiota-sparing-agents
#16
REVIEW
H G Maxwell-Scott, S D Goldenberg
Despite intense international attention and efforts to reduce its incidence, Clostridium difficile infection (CDI) remains a significant concern for patients, clinicians, and healthcare organizations. It is costly for payers and disabling for patients. Furthermore, recurrent CDI is particularly difficult to manage, resulting in excess mortality, hospital length of stay, and other healthcare resource use. A greater understanding of the role of the gut microbiome has emphasized the importance of this diverse community in providing colonization resistance against CDI...
November 20, 2017: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/29143555/qualitative-and-quantitative-prediction-of-human-in-vivo-metabolic-pathways-in-a-human-hepatocyte-murine-stromal-cell-co-culture-model
#17
Kenneth C Cassidy, Ping Yi
1. This study assessed the value of a static in vitro human hepatocyte-murine stromal cell co-culture model to qualitatively and quantitatively predict human in vivo metabolic clearance pathways using (14)C-labeled test compounds and compared these results to an in vitro suspended human hepatocyte model and the in vivo human (14)C ADME studies. 2. Test compounds represented a diverse set of clearance pathways (Phase I and Phase II). Compounds were incubated for 4 h in suspended human hepatocytes and for 24 and 168 h in the human co-culture model...
November 16, 2017: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/29119101/effect-of-dual-infection-with-eimeria-tenella-and-subgroup-j-avian-leukosis-virus-on-the-cecal-microbiome-in-specific-pathogen-free-chicks
#18
Ning Cui, Xiuzhen Wang, Qi Wang, Hongmei Li, Fangkun Wang, Xiaomin Zhao
Understanding gut microflora alterations associated with gut parasites and other pathogens that drive these alterations may help to promote the understanding of intestinal flora's role in multiple-infected individuals. This study examined the effects of dual infection with Eimeria tenella and subgroup J avian leukosis virus (ALV-J) on the chick cecal microbiome. Specific-pathogen-free (SPF) chicks were infected with either ALV-J strain NX0101 at 1 day of age or E. tenella at 14 days of age, another group was infected with both pathogens...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29117187/the-green-tea-modulates-large-intestinal-microbiome-and-exo-endogenous-metabolome-altered-through-chronic-uvb-exposure
#19
Eun Sung Jung, Hye Min Park, Seung Min Hyun, Jong Cheol Shon, Digar Singh, Kwang-Hyeon Liu, Tae Woong Whon, Jin-Woo Bae, Jae Sung Hwang, Choong Hwan Lee
The attenuating effects of green tea supplements (GTS) against the ultraviolet (UV) radiation induced skin damages are distinguished. However, the concomitant effects of GTS on the large intestinal microbiomes and associated metabolomes are largely unclear. Herein, we performed an integrated microbiome-metabolome analysis to uncover the esoteric links between gut microbiome and exo/endogenous metabolome maneuvered in the large intestine of UVB-exposed mice subjected to dietary GTS. In UVB-exposed mice groups (UVB), class Bacilli and order Bifidobacteriales were observed as discriminant taxa with decreased lysophospholipid levels compared to the unexposed mice groups subjected to normal diet (NOR)...
2017: PloS One
https://www.readbyqxmd.com/read/29113654/the-role-of-intestinal-bacteria-in-the-development-and-progression-of-gastrointestinal-tract-neoplasms
#20
REVIEW
Kosuke Mima, Shuji Ogino, Shigeki Nakagawa, Hiroshi Sawayama, Koichi Kinoshita, Ryuichi Krashima, Takatsugu Ishimoto, Katsunori Imai, Masaaki Iwatsuki, Daisuke Hashimoto, Yoshifumi Baba, Yasuo Sakamoto, Yo-Ichi Yamashita, Naoya Yoshida, Akira Chikamoto, Takatoshi Ishiko, Hideo Baba
More than 100 trillion microorganisms inhabit the human intestinal tract and play important roles in health conditions and diseases, including cancer. Accumulating evidence demonstrates that specific bacteria and bacterial dysbiosis in the gastrointestinal tract can potentiate the development and progression of gastrointestinal tract neoplasms by damaging DNA, activating oncogenic signaling pathways, producing tumor-promoting metabolites such as secondary bile acids, and suppressing antitumor immunity. Other bacterial species have been shown to produce short-chain fatty acids such as butyrate, which can suppress inflammation and carcinogenesis in the gastrointestinal tract...
December 2017: Surgical Oncology
keyword
keyword
93348
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"