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Herbal extract

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https://www.readbyqxmd.com/read/29786649/kudzu-leaf-extract-suppresses-the-production-of-inducible-nitric-oxide-synthase-cyclooxygenase-2-tumor-necrosis-factor-alpha-and-interleukin-6-via-inhibition-of-jnk-tbk1-and-stat1-in-inflammatory-macrophages
#1
Seok Hyun Eom, So-Jung Jin, Hee-Yeong Jeong, Youngju Song, You Jin Lim, Jong-In Kim, Youn-Hyung Lee, Hee Kang
Kudzu ( Pueraria montana var. lobata (Willd.) Sanjappa & Pradeep) is a perennial leguminous vine, and its root and flower have been used for herbal medicine in Asia for a long time. Most dietary flavonoids are reported to be concentrated in its root, not in its aerial parts including leaves. In this study, we investigated whether kudzu leaf and its major constituent, robinin (kaempferol-3- O -robinoside-7- O -rhanmoside) possessed anti-inflammatory activity. To test this hypothesis, we used peritoneal macrophages isolated from BALB/c mice and stimulated the cells with lipopolysaccharide (LPS) or LPS plus interferon (IFN)-γ...
May 22, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29784421/on-line-comprehensive-two-dimensional-liquid-chromatography-tandem-mass-spectrometry-for-the-analysis-of-curcuma-kwangsiensis
#2
Weijia Zhou, Zhimou Guo, Long Yu, Han Zhou, Aijin Shen, Yan Jin, Gaowa Jin, Jingyu Yan, Fan Yang, Yanming Liu, ChaoRan Wang, JiaTao Feng, Yanfang Liu, Xinmiao Liang
A novel online comprehensive two-dimensional liquid chromatography (2DLC) coupled with quadrupole time-of-flight (Q-TOF) mass spectrometry (MS) method is developed for the analysis of Curcuma kwangsiensis (C. kwangsiensis) extract. In this system, a newly developed phenyl/tetrazole sulfoether (PTAS) bonded stationary phase was introduced to construct RPLC×RPLC combined with C18. The unique structure endowed PTAS with very different selectivity from C18, reaching a high orthogonality of 93.2%. Moreover, such a combination settled compatibility issues because of the weaker hydrophobic retaining property of PTAS, thus allowing direct interfacing in online configuration...
August 15, 2018: Talanta
https://www.readbyqxmd.com/read/29782822/simultaneous-determination-of-intestinal-permeability-and-potential-drug-interactions-of-complex-mixtures-using-caco-2-cells-and-high-resolution-mass-spectrometry-studies-with-rauwolfia-serpentina-extract
#3
Thomas J Flynn, Sanah N Vohra
Caco-2 cells are a commonly used model for estimating the intestinal bioavailability of single chemical entity pharmaceuticals. Caco-2 cells, when induced with calcitriol, also express other biological functions such as phase I (CYP) and phase II (glucuronosyltransferases) drug metabolizing enzymes which are relevant to drug-supplement interactions. Intestinal bioavailability is an important factor in the overall safety assessment of products consumed orally. Foods, including herbal dietary supplements, are complex substances with multiple chemical components...
May 18, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29782704/profiling-of-new-psychoactive-substances-nps-by-using-stable-isotope-ratio-mass-spectrometry-irms-study-on-the-synthetic-cannabinoid-5f-pb-22
#4
S Münster-Müller, N Scheid, T Holdermann, S Schneiders, M Pütz
In this paper results of a pilot study on the profiling of the synthetic cannabinoid receptor agonist 5F-PB-22 (5F-QUPIC, pentylfluoro-1H-indole-3-carboxylic acid-8-quinolinyl ester) via isotope ratio mass spectrometry are presented. It is focused on δ13 C, δ15 N and δ2 H isotope ratios, which are determined using elemental analyser (EA) and high temperature elemental analyser (TC/EA) coupled to an isotope ratio mass spectrometer (IRMS). By means of a sample of pure material of 5F-PB-22 it is shown that the extraction of 5F-PB-22 from herbal material, a rapid clean-up procedure, or preparative column chromatography had no influences on the isotope ratios...
May 21, 2018: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29781089/the-effect-of-topical-piperine-combined-with-narrowband-uvb-on-vitiligo-treatment-a-clinical-trial-study
#5
Anoosh Shafiee, Mahmood Hoormand, Mohammad Shahidi-Dadras, Alireza Abadi
Vitiligo is the most common acquired hypopigmentary disease in the community. Piperine as an herbal extract derived from black pepper has strong impact on the melanocyte proliferation and adverse side effects less than synthetic drugs such as corticosteroids. For the first time, this study was aimed to evaluate the effect of topical piperine combined with narrowband ultraviolet B (NB-UVB) on vitiligo treatment. In this double-blind clinical trial, 63 patients with facial vitiligo were randomly divided into 2 groups: treated with piperine (case) and placebo (control)...
May 21, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29779402/traditional-and-complementary-medicine-use-among-indigenous-cancer-patients-in-australia-canada-new-zealand-and-the-united-states-a-systematic-review
#6
Alana Gall, Stuart Leske, Jon Adams, Veronica Matthews, Kate Anderson, Sheleigh Lawler, Gail Garvey
BACKGROUND: Cancer 'patients' are increasingly using traditional indigenous and complementary medicines (T&CM) alongside conventional medical treatments to both cure and cope with their cancer diagnoses. To date T&CM use among Indigenous cancer patients from Australia, Canada, New Zealand, and the United States has not been systematically reviewed. METHODS: We systematically searched bibliographic databases to identify original research published between January 2000 and October 2017 regarding T&CM use by Indigenous cancer patients in Australia, Canada, New Zealand, and the United States...
May 1, 2018: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/29773341/a-full-solution-for-multi-component-quantification-oriented-quality-assessment-of-herbal-medicines-chinese-agarwood-as-a-case
#7
Huixia Huo, Yao Liu, Wenjing Liu, Jing Sun, Qian Zhang, Yunfang Zhao, Jiao Zheng, Pengfei Tu, Yuelin Song, Jun Li
The quality of herbal medicines (HMs) is the prerequisite for their pronounced therapeutic outcomes in clinic, and multi-component (also known as quality markers, Q-markers) quantification has been widely emphasized as a viable means for quality evaluation. Because of the chemical diversity, the quality control practices are extensively dampened by four principal technical bottlenecks, including the lack of authentic compounds, large polarity span, extensive concentration range, and signal misrecognition for those potential Q-markers...
May 9, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29773000/evaluation-of-antiarthritic-activity-of-butanol-fraction-of-punica-granatum-linn-rind-extract-against-freund-s-complete-adjuvant-induced-arthritis-in-rats
#8
Rupesh Kumar Gautam, Sanjay Sharma, Komal Sharma, Gaurav Gupta
Available conventional drugs produce several side effects; thus, a potent herbal drug is urgently required for the management of rheumatoid arthritis. The present investigation was performed to evaluate the antiarthritic activity of butanol fraction of Punica granatum Linn. rind methanolic extract (PGBF) against Freund's complete adjuvant (FCA)-induced arthritis in rats. An acute toxicity study of butanol fraction was conducted, accompanied by a study of its antiarthritic activity. Chromatography (thin layer chromatography and high-performance thin layer chromatography) analyses were also conducted...
2018: Journal of Environmental Pathology, Toxicology and Oncology
https://www.readbyqxmd.com/read/29766799/anticancer-activity-of-an-oplopanax-elatus-stem-extract-and-biologically-active-isolated-compounds
#9
Jinfeng Yang, Yea-Ji Lee, Yong Soo Kwon, Myong Jo Kim
BACKGROUND AND METHODS: Oplopanax elatus (Nakai) Nakai is used in folk medicine in China. In this study, the antiproliferative activity of an O. elatus fraction extracted by ethyl acetate (EF) was tested on human breast cancer MCF-7 cells, human colon cancer HCT-116 cells, and human stomach cancer AGS cells. The potential mechanism of antiproliferation was also investigated using an apoptosis assay. RESULTS: The results showed that the EF remarkably suppressed proliferation of human breast, stomach, and colon cancer cells...
May 14, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29759936/in-vitro-antioxidant-antilipoxygenase-and-antimicrobial-activities-of-extracts-from-seven-climbing-plants-belonging-to-the-bignoniaceae
#10
Carola Analía Torres, Cristina Marisel Pérez Zamora, María Beatriz Nuñez, Ana María Gonzalez
OBJECTIVES: This study aimed to evaluate the in vitro antioxidant capacity, to determine the anti-inflammatory effect due to lipoxygenase inhibition and to test the antimicrobial activity of ethanolic extracts from leaves of seven climbing species belonging to the Bignoniaceae family. These species are Adenocalymma marginatum (Cham.) DC., Amphilophium vauthieri DC., Cuspidaria convoluta (Vell.) A. H. Gentry, Dolichandra dentata (K. Schum.) L. G. Lohmann, Fridericia caudigera (S. Moore) L...
May 3, 2018: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29758412/anti-inflammatory-effect-of-the-extracts-from-the-branch-of-taxillus-yadoriki-being-parasitic-in-neolitsea-sericea-in-lps-stimulated-raw264-7-cells
#11
Su Bin Park, Gwang Hun Park, Ha Na Kim, Ho-Jun Son, Hun Min Song, Hyun-Seok Kim, Hyung Jin Jeong, Jin Boo Jeong
Mistletoe has been used as the herbal medicine to treat hypertension, diabetes mellitus, inflammation, arthritis and viral infection. In this study, we evaluated the anti-inflammatory effect of extracts of branch from Taxillus yadoriki being parasitic in Neolitsea sericea (TY-NS-B) using in vitro model. TY-NS-B significantly inhibited LPS-induced secretion of NO and PGE2 in RAW264.7 cells. TY-NS-B was also observed to inhibit LPS-mediated iNOS COX-2 expression. In addition, TY-NS-B attenuated production of inflammatory cytokines such as TNF-α and IL-1β induced by LPS...
May 11, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29755562/investigation-of-%C3%AE-sitosterol-and-prangol-extracted-from-achillea-tenoifolia-along-with-whole-root-extract-on-isolated-rat-pancreatic-islets
#12
Mahban Rahimifard, Azadeh Manayi, Maryam Baeeri, Mahdi Gholami, Soodabeh Saeidnia, Mohammad Abdollahi
The genus Achillea (Asteraceae) consisting of important medicinal species, growing wildly in Iran, of which A. tenuifolia is found in Iran-o-Turan regions. Regarding the traditional use of Achillea species for treatment of diabetes and also lack of information on phyto-constituents of A. tenuifolia underground parts, in this study anti-diabetic activity of the plant have been reported. In order to find the main active components, underground parts of the plant were extracted with water and fractioned by hexane, ethyl acetate, and methanol and the separation of the main compounds were carried out via medium pressure liquid chromatography (MPLC)...
2018: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29755350/extracts-from-hypericum-hircinum-subsp-majus-exert-antifungal-activity-against-a-panel-of-sensitive-and-drug-resistant-clinical-strains
#13
Noemi Tocci, Daniele Perenzoni, Duilio Iamonico, Francesca Fava, Tobias Weil, Fulvio Mattivi
During the last two decades incidences of fungal infections dramatically increased and the often accompanying failure of available antifungal therapies represents a substantial clinical problem. The urgent need for novel antimycotics called particular attention to the study of natural products. The genus Hypericum includes many species that are used in the traditional medicine to treat pathological states like inflammations and infections caused by fungi. However, despite the diffused use of Hypericum -based products the antifungal potential of the genus is still poorly investigated...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29751604/graminex-pollen-phenolic-pattern-colorimetric-analysis-and-protective-effects-in-immortalized-prostate-cells-pc3-and-rat-prostate-challenged-with-lps
#14
Marcello Locatelli, Nicola Macchione, Claudio Ferrante, Annalisa Chiavaroli, Lucia Recinella, Simone Carradori, Gokhan Zengin, Stefania Cesa, Lidia Leporini, Sheila Leone, Luigi Brunetti, Luigi Menghini, Giustino Orlando
Prostatitis, a general term describing prostate inflammation, is a common disease that could be sustained by bacterial or non-bacterial infectious agents. The efficacy of herbal extracts with antioxidant and anti-inflammatory effects for blunting the burden of inflammation and oxidative stress, with possible improvements in clinical symptoms, is under investigation. Pollen extracts have been previously reported as promising agents in managing clinical symptoms related to prostatitis. The aim of the present work was to evaluate the protective effects of Graminex pollen (GraminexTM , Deshler, OH, USA), a commercially available product based on standardized pollen extracts, in rat prostate specimens, ex vivo...
May 11, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29751518/simultaneous-analysis-of-iridoid-glycosides-and-anthraquinones-in-morinda-officinalis-using-uplc-qqq-ms-ms-and-uplc-q-tof-ms-e
#15
Xiangsheng Zhao, Jianhe Wei, Meihua Yang
Morinda officinalis is an important herbal medicine and functional food, and its main constituents include anthraquinone and iridoid glycosides. Quantification of the main compounds is a necessary step to understand the quality and therapeutic properties of M. officinalis , but this has not yet been performed based on liquid chromatography/tandem mass spectrometry (LC-MS/MS). Analytes were extracted from M. officinalis by reflux method. Ultrahigh-performance liquid chromatography coupled with a triple quadrupole mass spectrometry (UPLC-QqQ-MS) using multiple reaction monitoring (MRM) mode was applied for quantification...
May 3, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29748470/effect-of-massoia-massoia-aromatica-becc-bark-on-the-phagocytic-activity-of-wistar-rat-macrophages
#16
Triana Hertiani, Agustinus Yuswanto, Sylvia Utami Tunjung Pratiwi, Harlyanti Muthma'innah Mashar
The essential oil of Massoia ( Massoia aromatica Becc., Lauraceae) bark is a potential immunomodulator in vitro. This study evaluated the potential immunomodulatory effects of Massoia bark infusion on the nonspecific immune response (phagocytosis) of Wistar rats. For the in vitro assay, macrophages were treated with the freeze-dried infusion at the concentrations of 2.5, 5, 10, 20, or 40 µg/mL media. For the in vivo assay, two-month-old male Wistar rats were divided into five groups. The baseline group received distilled water at the dose of 1 mL/100 g body weight (BW), with the herbal product containing Phyllanthus niruri extract that was administered as the positive control at the dose of 0...
May 10, 2018: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/29747745/the-potential-effect-of-garlic-extract-and-curcumin-nanoparticles-against-complication-accompanied-with-experimentally-induced-diabetes-in-rats
#17
Afaf D Abdel-Mageid, Mohamed E S Abou-Salem, Nancy M H A Salaam, Hoda A S El-Garhy
BACKGROUND: Modified herbal medicines implicate the combination of several therapeutic practices of native systems of medicine that may extend many earlier generations, which frequently afford valuable therapeutic benefits. PURPOSE: In this study, the role of nano-curcumin and aged garlic extract (AGE) as two modified phytomedicines on alleviating both of advanced glycation end products (AGEPs) and oxidative stress (OS) in streptozotocin (STZ) induced diabetic rats were investigated during this study...
April 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29746001/evaluation-of-antioxidant-properties-phenolic-compounds-anthelmintic-and-cytotoxic-activities-of-various-extracts-isolated-from-nepeta-cadmea-an-endemic-plant-for-turkey
#18
Arzu Kaska, Nahide Deniz, Mehmet Çiçek, Ramazan Mammadov
Nepeta cadmea Boiss. is a species endemic to Turkey that belongs to the Nepeta genus. Several species of this genus are used in folk medicine. This study was designed to investigate the phenolic compounds, antioxidant, anthelmintic, and cytotoxic activities of various extracts (ethanol, methanol, acetone, and water) of N. cadmea. The antioxidant activities of these extracts were analyzed using scavenging methods (DPPH, ABTS, and H2 O2 scavenging activity), the β-carotene/linoleic acid test system, the phosphomolybdenum method, and metal chelating activity...
May 10, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29745662/eucommia-ulmoides-oliver-a-potential-feedstock-for-bioactive-products
#19
Ming-Qiang Zhu, Run-Cang Sun
Eucommia ulmoides Oliver (EUO), a traditional Chinese herb, contains a variety of bioactive chemicals including lignans, iridoids, phenolics, steroids, terpenoids, flavonoids, etc. These bioactive chemicals possess the effective function in nourishing liver and kidney and regulating blood pressure. The composition of bioactive chemicals extracted from EUO vary to the different functional parts (leaves, seeds, bark and staminate flower) and planting models. The bioactive parts of EUO are widely utilized as raw materials for medicine and food, powdery extracts, herbal foumulations and tinctured extracts...
May 10, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29745530/-chinese-herbal-medicine-euphorbia-esula-extract-induces-apoptosis-and-inhibits-the-proliferation-migration-and-invasion-of-multidrug-resistant-gastric-carcinoma-cells
#20
Xianli Guo, Zhaoying Fu, Yun Bi, Jun Zheng, Lei Wang, Xiaolong He, Fei Li, Xing Lei, Qingquan Ren
This paper aims to study the effects of traditional Chinese medicine Euphorbia esula on multidrug resistant human gastric cancer cells in the cell proliferation, migration, invasion and apoptosis, and to study the apoptosis-inducing pathway. Different dilutions of Euphorbia esula extract were used to process human multidrug resistant gastric cancer SGC7901/ADR cells. Cell proliferation inhibition phenomenon was determined by MTT experiment. Nuclear morphological changes of apoptotic cells and apoptotic indexes were observed and determined by Hochest33528 staining followed with fluorescence microscope observing...
April 1, 2018: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
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