keyword
MENU ▼
Read by QxMD icon Read
search

kung fu

keyword
https://www.readbyqxmd.com/read/29595662/difference-between-elderly-and-non-elderly-patients-in-using-serum-lactate-level-to-predict-mortality-caused-by-sepsis-in-the-emergency-department
#1
Hsien-Hung Cheng, Fu-Cheng Chen, Meng-Wei Change, Chia-Te Kung, Chi-Yung Cheng, Tsung-Cheng Tsai, Sheng-Yuan Hsiao, Chih-Min Su
Elderly people are more susceptible to sepsis and experience more comorbidities and complications than young adults. Serum lactate is a useful biomarker to predict mortality in patients with sepsis. Lactate production is affected by the severity of sepsis, organ dysfunction, and adrenergic stimulation. Whether the predictive ability of serum lactate will be different between non-elderly and elderly patients is unknown.A retrospective cohort study was conducted to compare the prognostic value of hyperlactatemia in predicting the mortality between elderly (≥65 years) and non-elderly (<65 years) patients with sepsis...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29581766/large-intergenic-non-coding-rna-ror-inhibits-aerobic-glycolysis-of-glioblastoma-cells-via-akt-pathway
#2
Yong Li, Zhi-Cheng He, Qing Liu, Kai Zhou, Yu Shi, Xiao-Hong Yao, Xia Zhang, Hsiang-Fu Kung, Yi-Fang Ping, Xiu-Wu Bian
Reprogramming energy metabolism is a hallmark of malignant tumors, including glioblastoma (GBM). Aerobic glycolysis is often utilized by tumor cells to maintain survival and proliferation. However, the underlying mechanisms of aerobic glycolysis in GBM remain elusive. Herein, we demonstrated that large intergenic non-coding RNA-RoR (LincRNA-RoR) functioned as a critical suppressor to inhibit the aerobic glycolysis and viability of GBM cells. We found that LincRNA-RoR was markedly reduced in GBM tissues compared with adjacent non-tumor tissues from 10 cases of GBM patients...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29458935/everybody-was-kung-fu-fighting-the-beneficial-effects-of-tai-chi-qigong-and-self-defense-kung-fu-training-on-psychological-and-endocrine-health-in-middle-aged-and-older-men
#3
A Walther, T J Lacker, U Ehlert
BACKGROUND: Higher age is associated to a variety of physical and mental disorders. Age-related changes in steroid secretion have been suggested to be an underlying mechanism leading to frailty, depression, and sexual dysfunction. However, Tai chi qigong and similar forms of exercise have been shown to improve a great variety of health-related parameters in older individuals. METHODS: We examined 56 self-reporting healthy men actively practicing Tai chi qigong and/or self-defense Kung-fu and 55 age-matched self-reporting healthy controls...
February 2018: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/29457597/injectable-collagen-rgd-systems-for-bone-tissue-engineering-applications
#4
Fu-Chen Kung
Imbalance crosslink density and polymer concentration gradient is formed within the traditional alginate hydrogel using calcium chloride as a crosslinking agent in external gelation for instantaneously process. In this studying, type I collagen (Col I) blended calcium salt form of poly(γ-glutamic acid) (γCaPGA) was mixing with RGD-modified alginate with convenient gelation process and suitable for practical use. The hydrophilicity of the resulting hydrogels was evaluated through swelling tests, water retention capacity tests, and water vapor permeation tests...
2018: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/29381512/sex-difference-of-angiotensin-iv-lvv-hemorphin-7-and-oxytocin-induced-antiallodynia-at-the-spinal-level-in-mice-with-neuropathic-pain
#5
Lok-Hi Chow, Yuan-Hao Chen, Chun-Fu Lai, Tsu-You Lin, Ying-Jie Chen, Jen-Hsin Kao, Eagle Yi-Kung Huang
BACKGROUND: We demonstrated previously that angiotensin IV (Ang IV) and LVV-hemorphin 7 (LVV-H7) act through the blockade of insulin-regulated aminopeptidase to decrease oxytocin degradation, thereby causing antihyperalgesia at the spinal level in rats. We determined that intrathecal oxytocin can induce significant antihyperalgesia in male rats with inflammation but not in female rats. Thus, we speculate that Ang IV, LVV-H7, and oxytocin can induce antiallodynia, which could be of great therapeutic potential...
January 29, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29223982/pazopanib-sensitivity-in-a-patient-with-breast-cancer-and-fgfr1-amplification
#6
Fiona Tsui-Fen Cheng, Fu Ou-Yang, Nina Lapke, Kai-Che Tung, Yen-Kung Chen, Yuh-Yu Chou, Shu-Jen Chen
Treatment options for patients with hormone receptor-positive (HR+), HER2-negative (HER2-) breast cancer and resistance to endocrine therapy remain limited. An interesting therapeutic target in these patients is fibroblast growth factor receptor 1 ( FGFR1 ). FGFR1 is amplified in approximately 11% of patients with breast cancer, especially those with HR+ disease. This report presents a patient with metastatic HR+ HER2- breast cancer harboring an FGFR1 amplification who was resistant to endocrine therapy but responded to pazopanib, a multi-tyrosine kinase inhibitor with FGFR -inhibiting activity...
December 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29196129/stanniocalcin-1-augments-stem-like-traits-of-glioblastoma-cells-through-binding-and-activating-notch1
#7
Yong Li, Zhi-Cheng He, Xiao-Ning Zhang, Qing Liu, Cong Chen, Zheng Zhu, Qian Chen, Yu Shi, Xiao-Hong Yao, You-Hong Cui, Xia Zhang, Yan Wang, Hsiang-Fu Kung, Yi-Fang Ping, Xiu-Wu Bian
Glioblastoma (GBM) is a fatal tumor and comprises heterogeneous cells in which a subpopulation with stem cell-like properties is included. Cancer cells with stem cell-like properties account for tumor initiation, drug resistance and recurrence. To identify and characterize specific factors in regulating stem-like traits is critical for GBM therapeutic. Here, we showed that Stanniocalcin-1 (STC1), a secretory glycoprotein, functions as a novel stimulator for stem-like traits of GBM cells. We found STC1 was prominently expressed in glioma spheres which are mainly comprised of glioma stem-like cells...
March 1, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29169920/a-glycolysis-based-ten-gene-signature-correlates-with-the-clinical-outcome-molecular-subtype-and-idh1-mutation-in-glioblastoma
#8
Cong Chen, Yu Shi, Yong Li, Zhi-Cheng He, Kai Zhou, Xiao-Ning Zhang, Kai-Di Yang, Jin-Rong Wu, Hsiang-Fu Kung, Yi-Fang Ping, Xiu-Wu Bian
Reprogrammed metabolism is a hallmark of cancer. Glioblastoma (GBM) tumor cells predominantly utilize aerobic glycolysis for the biogenesis of energy and intermediate nutrients. However, in GBM, the clinical significance of glycolysis and its underlying relations with the molecular features such as IDH1 mutation and subtype have not been elucidated yet. Herein, based on glioma datasets including TCGA (The Cancer Genome Atlas), REMBRANDT (Repository for Molecular Brain Neoplasia Data) and GSE16011, we established a glycolytic gene expression signature score (GGESS) by incorporating ten glycolytic genes...
November 20, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29142066/characterization-of-sgn-cd123a-a-potent-cd123-directed-antibody-drug-conjugate-for-acute-myeloid-leukemia
#9
Fu Li, May Kung Sutherland, Changpu Yu, Roland B Walter, Lori Westendorf, John Valliere-Douglass, Lucy Pan, Ashley Cronkite, Django Sussman, Kerry Klussman, Michelle Ulrich, Martha E Anderson, Ivan J Stone, Weiping Zeng, Mechthild Jonas, Timothy S Lewis, Maitrayee Goswami, Sa A Wang, Peter D Senter, Che-Leung Law, Eric J Feldman, Dennis R Benjamin
Treatment choices for acute myelogenous leukemia (AML) patients resistant to conventional chemotherapies are limited and novel therapeutic agents are needed. IL3 receptor alpha (IL3Rα, or CD123) is expressed on the majority of AML blasts, and there is evidence that its expression is increased on leukemic relative to normal hematopoietic stem cells, which makes it an attractive target for antibody-based therapy. Here, we report the generation and preclinical characterization of SGN-CD123A, an antibody-drug conjugate using the pyrrolobenzodiazepine dimer (PBD) linker and a humanized CD123 antibody with engineered cysteines for site-specific conjugation...
February 2018: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29110162/recent-advances-in-the-pharmacological-management-of-gastroesophageal-reflux-disease
#10
REVIEW
Yu-Min Kung, Wen-Hung Hsu, Meng-Chieh Wu, Jiunn-Wei Wang, Chung-Jung Liu, Yu-Chung Su, Chao-Hung Kuo, Fu-Chen Kuo, Deng-Chyang Wu, Yao-Kuang Wang
The management of proton pump inhibitor-refractory GERD (rGERD) is a challenge in clinical practice. Since up to one-third of patients with typical GERD symptoms (heartburn and/or acid regurgitation) are not satisfied with proton pump inhibitor (PPI) therapy, new drug development targeting different pathophysiologies of GERD is imperative. At present, no other drugs serve as a more potent acid suppression agent than PPIs. As an add-on therapy, histamine type-2 receptor antagonists, alginates, prokinetics and transient lower esophageal sphincter relaxation inhibitors have some impact on the subgroups of rGERD, but greater effectiveness and fewer adverse effects for widespread use are required...
December 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29108348/decreased-risk-of-dementia-in-migraine-patients-with-traditional-chinese-medicine-use-a-population-based-cohort-study
#11
Chun-Ting Liu, Bei-Yu Wu, Yu-Chiang Hung, Lin-Yi Wang, Yan-Yuh Lee, Tsu-Kung Lin, Pao-Yen Lin, Wu-Fu Chen, Jen-Huai Chiang, Sheng-Feng Hsu, Wen-Long Hu
Patients with migraine are reportedly at increased risk of developing dementia. We aimed to investigate the association between traditional Chinese medicine (TCM) use and dementia risk in migraine patients. This longitudinal cohort study used the Taiwanese National Health Insurance Research Database to identify 32,386 diagnosed migraine patients aged 20 years and above who received treatment from 1997 to 2010. To balance comparability between TCM users and non-TCM users, we randomly selected equal numbers from each group, and compared subgroups compiled based on combinations of age, sex, index year, and year of migraine diagnosis...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29101647/plasma-mir-124-is-a-promising-candidate-biomarker-for-human-intracerebral-hemorrhage-stroke
#12
Zifeng Wang, Gang Lu, Johnny Sze, Yao Liu, Sheng Lin, Hong Yao, Ji Zhang, Dan Xie, Quentin Liu, Hsiang-Fu Kung, Marie Chia-Mi Lin, Wai Sang Poon
Stroke causes death or long-term disabilities and threatens the general health of the population worldwide. Recent studies have suggested that miRNAs are dysregulated and can be used as biomarkers for diagnosis and prognosis in stroke. The intracerebral hemorrhage (ICH) accounts for 15% of all the stroke cases. However, at present, little is known regarding the functions and clinical implications of miRNAs in ICH. In the present study, we established the collagenase-induced rat ICH model to mimic human ICH syndrome...
November 3, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/29074424/effect-of-baroreceptor-sensitivity-on-outcomes-in-patients-with-acute-spontaneous-intracerebral-hemorrhage
#13
Yun-Ru Lai, Yu-Jun Lin, Fu-Yuan Shih, Hung-Chen Wang, Nai-Wen Tsai, Chia-Te Kung, Wei-Che Lin, Ben-Chung Cheng, Yu-Jih Su, Ya-Ting Chang, Chih-Min Su, Sheng-Yuan Hsiao, Chih-Cheng Huang, Cheng-Hsien Lu
BACKGROUND: Reduced baroreflex sensitivity (BRS) has been reported in patients with acute cardiovascular events. We tested the hypothesis that BRS is substantially reduced in patients with spontaneous intracerebral hemorrhage (ICH) and that BRS can predict treatment outcomes. METHODS: We examined BRS and other cardiovascular autonomic parameters in 35 patients with ICH over the course of 30 days. Cardiovascular autonomic parameters also were evaluated in 30 healthy volunteer subjects during the study period...
January 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29046173/effects-of-physical-driving-experience-on-body-movement-and-motion-sickness-during-virtual-driving
#14
Chih-Hui Chang, Fu-Chen Chen, Wei-Ching Kung, Thomas A Stoffregen
BACKGROUND: In previous research on motion sickness in simulated and virtual vehicles, subjects' experience controlling the corresponding physical vehicles has been confounded with their age. During driving of virtual automobiles in a video game, we separated chronological age from experience driving physical automobiles. METHODS: Subjects drove a virtual automobile in a driving video game. Drivers were young adults with several years of experience driving physical automobiles, while nondrivers were individuals in the same age group who did not have a driver's license and had never driven an automobile...
November 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28988665/the-epidemiology-of-non-typhoidal-salmonella-gastroenteritis-and-campylobacter-gastroenteritis-in-pediatric-inpatients-in-northern-taiwan
#15
Chien-Fang Tseng, Nan-Chang Chiu, Ching-Ying Huang, Daniel Tsung-Ning Huang, Lung Chang, Yen-Hsin Kung, Fu-Yuan Huang, Hsin Chi
BACKGROUND: Campylobacter and Non-typhoidal Salmonella (NTS) are the two most common bacterial pathogens associated with acute gastroenteritis in children. This study aims to elucidate the epidemiology of Campylobacter and NTS gastroenteritis and develop a scoring system to differentiate them. MATERIALS AND METHODS: This retrospective study enrolled 886 children ≤18 years of age, hospitalized due to acute gastroenteritis with stool culture-proven Campylobacter or NTS infection from July 2012 to December 2015...
September 27, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28988664/epidemiology-and-antimicrobial-susceptibility-of-non-typeable-haemophilus-influenzae-in-otitis-media-in-taiwanese-children
#16
Ying-Chun Cho, Nan-Chang Chiu, Fu-Yuan Huang, Daniel Tsung-Ning Huang, Lung Chang, Ching-Ying Huang, Yen-Hsin Kung, Kuo-Sheng Lee, Hsin Chi
BACKGROUND: Concerns about non-typeable Haemophilus influenzae (NTHi) in otitis media (OM) have grown after the introduction of pneumococcal conjugate vaccine (PCV). We aim to better understand the clinical role of NTHi in pediatric OM. METHODS: Middle ear fluid samples from children <18 years with OM were obtained from 2010 to 2015. For culture-positive episodes (Streptococcus pneumoniae, H. influenzae, Moraxella catarrhalis, and Streptococcus pyogenes), patients' demographic and clinical information were reviewed and analyzed...
September 18, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28962182/gypenosides-induce-cell-death-and-alter-gene-expression-in-human-oral-cancer-hsc-3-cells
#17
Kung-Wen Lu, Yi-Shih Ma, Fu-Shun Yu, Yi-Ping Huang, Yung-Lin Chu, Rick Sai-Chuen Wu, Ching-Lung Liao, Fu-Shin Chueh, Jing-Gung Chung
Gypenosides (Gyp), the primary components of Gynostemma pentaphyllum Makino, have long been used as a Chinese herbal medicine. In the present study, the effects of Gyp on cell viability, the cell cycle, cell apoptosis, DNA damage and chromatin condensation were investigated in vitro using human oral cancer HSC-3 cells. The results of the present study indicated that Gyp induces cell death, G2/M phase arrest and apoptosis in HSC-3 cells in a dose-dependent manner. It was also demonstrated that Gyp decreased the depolarization of mitochondrial membrane potential in a time-dependent manner...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28944643/injury-rates-in-martial-art-athletes-anthropometric-parameters-and-training-volume-but-not-foot-morphology-indexes-are-predictive-risk-factors-for-lower-limb-injuries
#18
Jacopo A Vitale, Tito Bassani, Fabio Galbusera, Alberto Bianchi, Nicolò Martinelli
BACKGROUND: Previous studies attempted to identify possible risk factors for acute and overuse injuries in several sports disciplines such as running, gymnastics or team sports. Given the lack of scientific works focused on risk factors for lower limb injuries in martial arts, the present study was aimed to investigate foot anatomy, anthropometric measures, and other background information as possible risk factors of injury in barefoot athletes practicing judo, karate, kung fu, thai boxe, or aikido...
September 22, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28918242/predictive-value-of-thomsen-friedenreich-antigen-activation-for-streptococcus-pneumoniae-infection-and-severity-in-pediatric-lobar-pneumonia
#19
Chia-Jung Chang, Nan-Chang Chiu, Fu-Yuan Huang, Daniel Tsung-Ning Huang, Lung Chang, Ching-Ying Huang, Yen-Hsin Kung, Hsin Chi
BACKGROUND: Most cases of complicated pneumonia in children are caused by pneumococcal infections. Thomsen-Friedenreich antigen (TA) is present on erythrocytes, platelets and glomeruli, and it can be activated during pneumococcal infection. The aim of this study was to investigate the predictive value of TA activation for pneumococcal infection and association with the severity of complicated pneumonia. MATERIALS AND METHODS: Patients with lobar pneumonia were routinely tested for TA at the Department of Pediatrics, Mackay Memorial Hospital from January 2010 to December 2015...
September 2, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28900621/using-a-cloud-computing-system-to-reduce-door-to-balloon-time-in-acute-st-elevation-myocardial-infarction-patients-transferred-for-percutaneous-coronary-intervention
#20
Chi-Kung Ho, Fu-Cheng Chen, Yung-Lung Chen, Hui-Ting Wang, Chien-Ho Lee, Wen-Jung Chung, Cheng-Jui Lin, Shu-Kai Hsueh, Shin-Chiang Hung, Kuan-Han Wu, Chu-Feng Liu, Chia-Te Kung, Cheng-I Cheng
BACKGROUND: This study evaluated the impact on clinical outcomes using a cloud computing system to reduce percutaneous coronary intervention hospital door-to-balloon (DTB) time for ST segment elevation myocardial infarction (STEMI). METHODS: A total of 369 patients before and after implementation of the transfer protocol were enrolled. Of these patients, 262 were transferred through protocol while the other 107 patients were transferred through the traditional referral process...
2017: BioMed Research International
keyword
keyword
93334
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"