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https://www.readbyqxmd.com/read/28420503/age-is-a-major-prognosticator-in-extremely-low-oocyte-retrieval-cycles
#1
Yu-Ting Su, Pin-Yao Lin, Fu-Jen Huang, Fu-Tsai Kung, Yu-Ju Lin, Yi-Ru Tsai, Kuo-Chung Lan
OBJECTIVE: Clinical prognosis appears to be varied in females with poor ovarian response (POR), and poor responders defined by the Bologna criteria might not be sufficiently homogeneous. The aim of this study was to determine the major predictor of reproductive outcomes in extremely low oocyte retrieval cycles. MATERIALS AND METHODS: A cohort of fresh in vitro fertilization/intracytoplasmic sperm injection cycles (n = 858) was analyzed from January 2001 to September 2014...
April 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28334864/coordination-among-tertiary-base-pairs-results-in-an-efficient-frameshift-stimulating-rna-pseudoknot
#2
Yu-Ting Chen, Kai-Chun Chang, Hao-Teng Hu, Yi-Lan Chen, You-Hsin Lin, Chiung-Fang Hsu, Cheng-Fu Chang, Kung-Yao Chang, Jin-Der Wen
Frameshifting is an essential process that regulates protein synthesis in many viruses. The ribosome may slip backward when encountering a frameshift motif on the messenger RNA, which usually contains a pseudoknot structure involving tertiary base pair interactions. Due to the lack of detailed molecular explanations, previous studies investigating which features of the pseudoknot are important to stimulate frameshifting have presented diverse conclusions. Here we constructed a bimolecular pseudoknot to dissect the interior tertiary base pairs and used single-molecule approaches to assess the structure targeted by ribosomes...
February 21, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28255170/nucleophosmin-interacts-with-pin2-terf1-interacting-telomerase-inhibitor-1-pinx1-and-attenuates-the-pinx1-inhibition-on-telomerase-activity
#3
Derek Hang-Cheong Cheung, Sai-Tim Ho, Kwok-Fai Lau, Rui Jin, Ya-Nan Wang, Hsiang-Fu Kung, Jun-Jian Huang, Pang-Chui Shaw
Telomerase activation and telomere maintenance are critical for cellular immortalization and transformation. PIN2/TERF1-interacting telomerase inhibitor 1 (PinX1) is a telomerase regulator and the aberrant expression of PinX1 causes telomere shortening. Identifying PinX1-interacting proteins is important for understanding telomere maintenance. We found that PinX1 directly interacts with nucleophosmin (NPM), a protein that has been shown to positively correlate with telomerase activity. We further showed that PinX1 acts as a linker in the association between NPM and hTERT, the catalytic subunit of telomerase...
March 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28254232/comparing-the-midterm-outcome-of-single-incision-vaginal-mesh-and-transobturator-vaginal-mesh-in-treating-severe-pelvic-organ-prolapse
#4
Tsai-Hwa Yang, Ling-Ying Wu, Fei-Chi Chuang, Fu-Tsai Kung, Kuan-Hui Huang
OBJECTIVE: The aim of this study is to compare perioperative parameters and midterm clinical outcomes using two different mesh kits: transobturator vaginal mesh (TVM) (both Perigee and Apogee), versus single incision vaginal mesh (SIM) (combined Elevate anterior/apical system and Elevate posterior/apical system) in treating severe pelvic organ prolapse (POP). MATERIALS AND METHODS: This is a retrospective cohort study. During 2008 and 2013, those women with severe POP [POP quantification system (POP-Q), Stage III and Stage IV], who received either TVM or SIM operation, were enrolled for cohort comparison...
February 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28252668/aggretin-venom-polypeptide-as-a-novel-anti-angiogenesis-agent-by-targeting-integrin-alpha2beta1
#5
Ching Hu Chung, Chien Hsin Chang, Chun Chieh Hsu, Kung Tin Lin, Hui Chin Peng, Tur Fu Huang
VEGF and VEGFR antibodies have been used as a therapeutic strategy to inhibit angiogenesis in many diseases; however, frequent and repeated administration of these antibodies to patients induces immunogenicity. In previous studies, we demonstrated that aggretin, a heterodimeric snake venom C-type lectin, exhibits pro-angiogenic activities via integrin α2β1 ligation. We hypothesised that small-mass aggretin fragments may bind integrin α2β1 and act as antagonists of angiogenesis. In this study, the anti-angiogenic efficacy of a synthesised aggretin α-chain C-terminus (AACT, residue 106-136) was evaluated in both in vitro and in vivo angiogenesis models...
March 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28181380/fisetin-induced-apoptosis-of-human-oral-cancer-scc-4-cells-through-reactive-oxygen-species-production-endoplasmic-reticulum-stress-caspase-and-mitochondria-dependent-signaling-pathways
#6
Chen-Hsuan Su, Chao-Lin Kuo, Kung-Wen Lu, Fu-Shun Yu, Yi-Shih Ma, Jiun-Long Yang, Yung-Lin Chu, Fu-Shin Chueh, Kuo-Ching Liu, Jing-Gung Chung
Oral cancer is one of the cancer-related diseases in human populations and its incidence rates are rising worldwide. Fisetin, a flavonoid from natural products, has been shown to exhibit anticancer activities in many human cancer cell lines but the molecular mechanism of fisetin-induced apoptosis in human oral cancer cells is still unclear; thus, in this study, we investigated fisetin-induced cell death and associated signal pathways on human oral cancer SCC-4 cells in vitro. We examined cell morphological changes, total viable cells, and cell cycle distribution by phase contrast microscopy and flow cytometry assays...
February 9, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/28152037/reassessing-the-feasibility-of-the-zygote-score-for-predicting-embryo-viability-in-ivf-icsi-using-the-gnrh-antagonist-protocol-compared-to-the-long-protocol
#7
Pin-Yao Lin, Fu-Jen Huang, Fu-Tsai Kung, Yi-Chi Lin, Hsin-Ju Chiang, Yu-Ju Lin, Kuo-Chung Lan
BACKGROUND: Many factors from the oocyte/sperm or the process of fertilization may affect the zygote formation. The zygote score (Z-score) describes the quality of a human zygote based on its pronuclear morphology, nucleolar precursor bodies, and alignment of polar bodies, and it can be used in the selection process at the zygote stage for embryo transfer or cryopreservation. OBJECTIVE: The aim of this retrospective cohort study was to investigate the relationship between different controlled ovarian stimulation (COS) protocols and the zygote score (Z-score) and to assess the feasibility of the Z-score for predicting embryo survival in the GnRH-antagonist (GnRH-ant) protocol...
2017: PloS One
https://www.readbyqxmd.com/read/28121953/the-influence-of-resident-seniority-on-supervised-practice-in-the-emergency-department
#8
I-Min Chiu, Yuan-Jhen Syue, Chia-Te Kung, Fu-Jen Cheng, Chien-Hung Lee, Yan-Ren Lin, Chao-Jui Li
To investigate the influence of resident seniority on supervised clinical practice in the emergency department (ED).This was a retrospective, 1-year cohort study conducted in 5 EDs within Taiwan largest healthcare system. All adult nontrauma visits presenting to the EDs during the day shift between July 1, 2011 and June 30, 2012 were included in the analysis. Visits were divided into supervised (ie, treated by resident under attending physician's supervision) and attending-alone. Supervised visits were further categorized by resident seniority (junior, intermediate, and senior)...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27859216/cooperation-of-mll-af10-om-lz-with-ptpn11-activating-mutation-induced-monocytic-leukemia-with-a-shorter-latency-in-a-mouse-bone-marrow-transplantation-model
#9
Jen-Fen Fu, Sung-Tzu Liang, Ying-Jung Huang, Kung-Hao Liang, Tzung-Hai Yen, Der-Cherng Liang, Lee-Yung Shih
PTPN11 mutation, a RAS signaling pathway mutation, is associated with MLL translocations in acute leukemia. A girl with MLL/AF10 AML was found to carry PTPN11(G503A) . To study the impact of PTPN11(G503A) cooperating with MLL/AF10 on leukemogenesis, we established a retroviral transduction/transplantation mouse model. Compared to the MLL/AF10(OM-LZ) leukemia cells harboring PTPN11(wt) , the cells harboring PTPN11(G503A) were hypersensitive to GM-CSF and IL3, and more resistant to death upon treatment with daunorubicin but sensitive to cytarabine...
March 1, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27813227/mir-34a-modulates-erbb2-in-breast-cancer
#10
Yilin Wang, Xiaolong Zhang, Zou Chao, Hsiang-Fu Kung, Marie C Lin, Andreas Dress, Fiona Wardle, Bing-Hua Jiang, Lihui Lai
Breast cancer is the second highest cause of carcinoma-related death caused by distant metastasis in women. Estrogen receptor (ER), human epidermal growth factor receptor 2, (HER2) and progesterone receptor (PR) are three classified makers of breast cancer, which are defined as ER+, HER2+, and the most serious ER-PR-HER2- (triple-negative). It is well known that ErbB2 (V-Erb-B2 avian erythroblastic leukemia viral oncogene homolog 2) plays an important part in breast cancer. However, the molecular mechanisms underlying ErbB2 action needs to be well studied...
January 2017: Cell Biology International
https://www.readbyqxmd.com/read/27766260/the-prognosis-of-cardiac-origin-and-noncardiac-origin-in-hospital-cardiac-arrest-occurring-during-night-shifts
#11
Yuan-Jhen Syue, Jyun-Bin Huang, Fu-Jen Cheng, Chia-Te Kung, Chao-Jui Li
Background. The survival rates of in-hospital cardiac arrests (IHCAs) are reportedly low at night, but the difference between the survival rates of cardiac origin and noncardiac origin IHCAs occurring at night remains unclear. Methods. Outcomes of IHCAs during different shifts (night, day, and evening) were compared and stratified according to the etiology (cardiac and noncardiac origin). Result. The rate of return of spontaneous circulation (ROSC) was 24.7% lower for cardiac origin IHCA and 19.4% lower for noncardiac origin IHCA in the night shift than in the other shifts...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27754332/tetrandrine-induces-apoptosis-of-human-nasopharyngeal-carcinoma-npc-tw-076-cells-through-reactive-oxygen-species-accompanied-by-an-endoplasmic-reticulum-stress-signaling-pathway
#12
Ya-Jing Lin, Shu-Fen Peng, Meng-Liang Lin, Chao-Lin Kuo, Kung-Wen Lu, Ching-Lung Liao, Yi-Shih Ma, Fu-Shin Chueh, Kuo-Ching Liu, Fu-Shun Yu, Jing-Gung Chung
Nasopharyngeal carcinoma (NPC) is an epithelial malignancy of the head and neck and the incidence is higher in Southeast Asia. Tetrandrine (TET) is a bisbenzylisoquinoline alkaloid, a natural product, and exhibits biological activities including action against many human cancer cell lines. However, the molecular mechanism of TET-induced cell apoptosis in human NPC cells is still unclear. In the present study, we investigated TET-induced apoptotic cell death and associated possible signal pathways on human nasopharyngeal carcinoma NPC-TW 076 cells in vitro...
October 12, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27751415/validation-of-the-traditional-chinese-version-of-the-prolapse-quality-of-life-questionnaire-p-qol-in-a-mandarin-speaking-taiwanese-population
#13
MULTICENTER STUDY
Fei-Chi Chuang, Li-Ching Chu, Fu-Tsai Kung, Kuan-Hui Huang
OBJECTIVE: To validate the traditional Chinese translated version of the prolapse quality of life questionnaire (P-QOL). MATERIALS AND METHODS: The P-QOL questionnaire was translated into traditional Chinese characters and administered to women recruited from gynecologic outpatient clinics of Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan. After the test-retest reliability and internal consistency were established in a pilot study, all participants completed the P-QOL questionnaire and were examined in the lithotomy position using the Pelvic Organ Prolapse Quantification System (POP-Q)...
October 2016: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27742031/distinct-subpopulations-of-hepatitis-c-virus-infectious-cells-with-different-levels-of-intracellular-hepatitis-c-virus-core-protein
#14
Shu-Chi Wang, Jeng-Fu Yang, Chao-Ling Wang, Chung-Feng Huang, Yu-Yin Lin, Yi-You Chen, Chung-Ting Lo, Po-Yen Lee, Kuan-Ta Wu, Chia-I Lin, Meng-Hsuan Hsieh, Hung-Yi Chuang, Chi-Kung Ho, Ming-Lung Yu, Chia-Yen Dai
Chronic infection by hepatitis C virus (HCV) is a major risk factor for the development of hepatocellular carcinoma (HCC). Despite the clear clinical importance of virus-associated HCC, the underlying molecular mechanisms remain largely unclarified. Oxidative stress, in particular, DNA lesions associated with oxidative damage, plays a major role in carcinogenesis, and is strongly linked to the development of many cancers, including HCC. However, in identifying hepatocytes with HCV viral RNA, estimates of the median proportion of HCV-infected hepatocytes have been found as high as 40% in patients with chronic HCV infection...
October 2016: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/27726326/achieving-low-energy-driven-viologens-based-electrochromic-devices-utilizing-polymeric-ionic-liquids
#15
Hsin-Che Lu, Sheng-Yuan Kao, Hsin-Fu Yu, Ting-Hsiang Chang, Chung-Wei Kung, Kuo-Chuan Ho
Herein, three kinds of viologens-based electrochromic devices (ECDs) (heptyl viologen (HV(BF4)2), octyl viologen (OV(BF4)2), and nonyl viologen (NV(BF4)2)) were fabricated utilizing ferrocene (Fc) as a redox mediator. Among them, the NV(BF4)2-based ECD exhibits the highest coloration efficiency (36.2 cm(2)/C) owing to the lowest driving energy. Besides, switching between 0 and 1.2 V, the NV(BF4)2-based ECD shows a desirable initial transmittance change (ΔT = 56.7% at 605 nm), and long-term stability (ΔT = 45...
November 9, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27714998/prominent-vascularization-capacity-of-mesenchymal-stem-cells-in-collagen-gold-nanocomposites
#16
Shuchen Hsieh, Hui-Jye Chen, Shan-Hui Hsu, Yi-Chun Yang, Cheng-Ming Tang, Mei-Yun Chu, Pei-Ying Lin, Ru-Huei Fu, Mei-Lang Kung, Yun-Wen Chen, Bi-Wen Yeh, Huey-Shan Hung
The ideal characteristics of surface modification on the vascular graft for clinical application would be with excellent hemocompatibility, endothelialization capacity, and anti-restenosis ability. Here, Fourier transform infrared spectroscopy (FTIR), surface enhanced raman spectroscopy (SERS), atomic force microscopy (AFM), contact angle () measurement, and thermogravimetric analyzer (TGA) were used to evaluate the chemical and mechanical properties of collagen-gold nanocomposites (collagen+Au) with 17...
October 7, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27676825/isokinetic-strength-trunk-assessment-of-athletes
#17
Amira Zouita Ben Moussa
OBJECTIVE: Sport specific consideration, different demands of various sports and specific training reveal differences of trunk strength capacity. The purpose of this study was to identify strength firstly characteristics of isokinetic parameters of trunk of athletes and secondary to detect the difference and the effect of sports. MATERIAL/PATIENTS AND METHODS: Sixteen athletes of national team athletes were recruited for the study: weightlifting and wrestlers to participate in this study...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27664399/in-silico-prediction-and-in-vitro-and-in-vivo-validation-of-acaricide-fluazuron-as-a-potential-inhibitor-of-fgfr3-and-a-candidate-anticancer-drug-for-bladder-carcinoma
#18
Kunbin Ke, Hongjian Li, Hong Yao, Xi-Nan Shi, Chao Dong, Ying Zhu, Xu Liu, Ling Li, Kwong-Sak Leung, Man-Hon Wong, Xiao-Dong Liu, Hsiang-Fu Kung, Marie Chia-Mi Lin
Bladder carcinoma (BC) is the ninth most common cause of cancer worldwide. Surgical resection and conventional chemotherapy and radiotherapy will ultimately fail due to tumor recurrence and resistance. Thus, the development of novel treatment is urgently needed. Fibroblast growth factor receptor 3 (FGFR3) is an important and well-established target for BC treatment. In this study, we utilized the free and open-source protein-ligand docking software idock to prospectively identify potential inhibitors of FGFR3 from 3,167 worldwide approved small-molecule drugs using a repositioning strategy...
April 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/27659552/transcatheter-arterial-embolization-as-first-line-rescue-in-intractable-primary-postpartum-hemorrhage-assessment-outcome-and-subsequent-fertility
#19
Hsin-Hsin Cheng, Leo Leung-Chit Tsang, Te-Yao Hsu, Chia-Te Kung, Chia-Yu Ou, Ching-Di Chang, Ching-Chang Tsai, Yu-Fan Cheng, Fu-Tsai Kung
BACKGROUND/PURPOSE: To assess the risk factors for intractable and controllable postpartum hemorrhage (PPH) and to evaluate the safety, efficacy, and outcome of transcatheter arterial embolization (TAE). METHODS: An emergency PPH rescue system including the 24-hour-available TAE was established in 2004. TAE with gelatine sponge particles placed on bilateral uterine or internal iliac arteries served as the first-line treatment for intractable PPH. Delivery methods, parity, causes of bleeding, clinical vital signs, coagulopathy, success rate, resumption of menstruation, and subsequent pregnancy outcome after TAE were recorded...
May 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/27450026/comparison-of-the-clinical-outcomes-of-transobturator-and-single-incision-slings-for%C3%A2-stress%C3%A2-urinary-incontinence
#20
COMPARATIVE STUDY
Ling-Ying Wu, Tsai-Hwa Yang, Fu-Tsai Kung, Fei-Chi Chuang, Kuan-Hui Huang
The aim of this study was to compare the clinical outcomes of anti-incontinence surgeries employing the transobturator sling and single-incision sling (SIS). Our hypothesis is that the outcome of the SIS is not inferior to the obturator sling. This retrospective study reviewed the medical records of patients who underwent anti-incontinence surgery with the transobturator sling or SIS from July 2005 to November 2014. Patients who underwent concomitant pelvic organ reconstruction with an artificial mesh were excluded...
July 2016: Kaohsiung Journal of Medical Sciences
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