keyword
https://read.qxmd.com/read/38525338/association-between-organophosphate-flame-retardant-exposure-and-lipid-metabolism-data-from-the-2013-2014-national-health-and-nutrition-examination-survey
#1
JOURNAL ARTICLE
Fu-Jen Cheng, Kai-Fan Tsai, Kuo-Chen Huang, Chia-Te Kung, Wan-Ting Huang, Huey-Ling You, Shau-Hsuan Li, Chin-Chou Wang, Wen-Chin Lee, Hsiu-Yung Pan
Organophosphate flame retardants (OPFRs) are emerging environmental pollutants that can be detected in water, dust, and biological organisms. Certain OPFRs can disrupt lipid metabolism in animal models and cell lines. However, the effects of OPFRs on human lipid metabolism remain unclear. We included 1,580 participants (≥20 years) from the 2013-2014 National Health and Nutrition Examination Survey (NHANES) to explore the relationship between OPFR exposure and lipid metabolism biomarkers. After adjusting for confounding factors, results showed that one-unit increases in the log levels of diphenyl phosphate (DPhP) (regression coefficient = -5...
2024: Frontiers in Public Health
https://read.qxmd.com/read/38485315/comparison-of-miscarriage-rates-in-low-prognosis-patients-according-to-the-poseidon-criteria
#2
JOURNAL ARTICLE
Yu-Yang Hsiao, Ni-Chin Tsai, Yu-Ting Su, Yu-Ju Lin, Hsin-Ju Chiang, Fu-Tsai Kung, Kuo-Chung Lan
OBJECTIVE: The POSEIDON criteria stratified patients with poor ovarian response into four subgroups with exclusive characteristics and assisted reproductive technology success rates. However, limited studies focused on miscarriage in the POSEIDON population. This study aimed to explore whether the miscarriage rate different among low prognosis patients according to POSEIDON criteria. MATERIALS AND METHODS: This is a retrospective observational study. All clinical pregnancies achieved after in vitro fertilization or intracytoplasmic sperm injection treatment between January 1998 and April 2021 were analyzed...
March 2024: Taiwanese Journal of Obstetrics & Gynecology
https://read.qxmd.com/read/38443405/uncovering-the-microbiome-landscape-in-sashimi-delicacies
#3
JOURNAL ARTICLE
Cheng-Wei Ho, Pei-Ying Chen, Yi-Ting Liao, Yen-Fu Cheng, Han-Hsing Tsou, Tsung-Yun Liu, Kung-Hao Liang
It is widely believed that a significant portion of the gut microbiota, which play crucial roles in overall health and disease, originates from the food we consume. Sashimi is a type of popular raw seafood cuisine. Its microbiome, however, remained to be thoroughly explored. The objective of this study is to explore the microbiome composition in sashimi at the time when it is served and ready to be eaten. Specifically, our tasks include investigating the diversity and characteristics of microbial profiles in sashimi with respect to the fish types...
March 5, 2024: Scientific Reports
https://read.qxmd.com/read/38342036/kaposi-sarcoma-herpesvirus-human-herpesvirus-8-positive-diffuse-large-b-cell-lymphoma-characterized-by-malignant-ascites-a-case-report
#4
Li-Chang Chang, Pei-An Fu, Shu-Hsien Wang, Kung-Chao Chang, Ya-Ting Hsu
Herein, we report a rare case of Kaposi sarcoma herpesvirus/human herpesvirus 8 (KSHV/HHV8)-positive diffuse large B-cell lymphoma (DLBCL), which is characterized by malignant ascites and complex karyotypes. A 72-year-old male patient who tested negative for human immunodeficiency virus presented with thrombocytopenia and lymphadenopathies. He was diagnosed with KSHV/HHV8-associated multicentric Castleman disease (MCD). After three years, he developed progressive lymphadenopathies and massive ascites. The lymphoma cells in the ascitic fluid presented with characteristic immunophenotype and monoclonality, which support the diagnosis of KSHV/HHV8-positive DLBCL...
February 1, 2024: Pathology, Research and Practice
https://read.qxmd.com/read/38341830/age-prediction-using-resting-state-functional-mri
#5
JOURNAL ARTICLE
Jose Ramon Chang, Zai-Fu Yao, Shulan Hsieh, Torbjörn E M Nordling
The increasing lifespan and large individual differences in cognitive capability highlight the importance of comprehending the aging process of the brain. Contrary to visible signs of bodily ageing, like greying of hair and loss of muscle mass, the internal changes that occur within our brains remain less apparent until they impair function. Brain age, distinct from chronological age, reflects our brain's health status and may deviate from our actual chronological age. Notably, brain age has been associated with mortality and depression...
February 11, 2024: Neuroinformatics
https://read.qxmd.com/read/38305483/structure-based-approaches-against-covid-19
#6
REVIEW
Ta-Chou Huang, Kung-Hao Liang, Tai-Jay Chang, Kai-Feng Hung, Mong-Lien Wang, Yen-Fu Cheng, Yi-Ting Liao, De-Ming Yang
The coronavirus disease 2019 (COVID-19) pandemic has had a major impact on human life. This review highlights the versatile roles of both classical and modern structure-based approaches for COVID-19. X-ray crystallography, nuclear magnetic resonance spectroscopy, and cryogenic electron microscopy are the three cornerstones of classical structural biology. These technologies have helped provide fundamental and detailed knowledge regarding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the related human host proteins as well as enabled the identification of its target sites, facilitating the cessation of its transmission...
February 1, 2024: Journal of the Chinese Medical Association: JCMA
https://read.qxmd.com/read/38287325/flt3l-induced-virtual-memory-cd8-t-cells-engage-the-immune-system-against-tumors
#7
JOURNAL ARTICLE
Hsin-Fang Tu, Yu-Jui Kung, Ling Lim, Julia Tao, Ming-Hung Hu, Michelle Cheng, Deyin Xing, T C Wu, Chien-Fu Hung
BACKGROUND: Previous research in FMS-like tyrosine kinase 3 ligands (FLT3L) has primarily focused on their potential to generate dendritic cells (DCs) from bone marrow progenitors, with a limited understanding of how these cells affect CD8 T cell function. In this study, we further investigated the in vivo role of FLT3L for the immunomodulatory capabilities of CD8 T cells. METHODS: Albumin-conjugated FLT3L (Alb-FLT3L) was generated and applied for translational medicine purposes; here it was used to treat naïve C57BL/6 and OT1 mice for CD8 T cell response analysis...
January 29, 2024: Journal of Biomedical Science
https://read.qxmd.com/read/38193541/profiling-of-vegf-receptors-and-immune-checkpoints-in-recurrent-respiratory-papillomatosis
#8
JOURNAL ARTICLE
Brandon Lam, Jonas Miller, Yu Jui Kung, T C Wu, Chien-Fu Hung, Richard Roden, Simon R Best
OBJECTIVES: Recurrent respiratory papillomatosis (RRP) is caused by human papilloma virus (HPV) infection of the aerodigestive tract that significantly impacts quality-of-life including the ability to communicate and breathe. Treatment was traditionally limited to serial ablative procedures in the O.R. with possible local adjuvant therapy, but new systemic therapies, such as Vascular endothelial growth factor (VEGF) inhibitors, are showing significant promise. This study aims to determine whether rationale exists for combination therapeutic approaches using VEGF inhibitors and/or immune checkpoint blockade...
January 9, 2024: Laryngoscope
https://read.qxmd.com/read/38095463/-a-castellanii-and-p-aeruginosa-mutually-exacerbate-damage-to-corneal-cells-during-coinfection
#9
JOURNAL ARTICLE
Chun-Hsien Chen, Chen-Chieh Liao, Yu-Jen Wang, Fu-Chin Huang, Wei-Chen Lin
At the National Cheng Kung University Hospital, numerous cases of amoebic keratitis had been identified with concurrent bacterial infections. Among these bacterial coinfections, Pseudomonas aeruginosa accounted for 50% of the reported cases. However, the impact of pathogenic bacteria on amoeba-induced corneal damage remains unclear. In our study, we successfully demonstrated that P. aeruginosa accumulated on the Acanthamoeba castellanii surface and caused more severe corneal damage. We also indicated that the exposure of P...
December 14, 2023: Microbiology Spectrum
https://read.qxmd.com/read/38072989/effect-of-different-types-of-tai-chi-exercise-programs-on-the-rate-of-change-in-bone-mineral-density-in-middle-aged-adults-at-risk-of-osteoporosis-a-randomized-controlled-trial
#10
JOURNAL ARTICLE
Jianda Kong, Chunlan Tian, Lei Zhu
OBJECTIVE: To evaluate three Tai Chi (TC) exercise programs as intervention measures to compare their effects on improving rate of change in bone mineral density (BMD) in elderly individuals with osteoporosis (OP) and to propose the optimal exercise duration. METHODS: A randomized controlled trial (RCT) was conducted to identify study participants based on inclusion and exclusion criteria. Due to subject attrition, the number of participants analyzed decreased from 60 to 49...
December 11, 2023: Journal of Orthopaedic Surgery and Research
https://read.qxmd.com/read/38008500/setting-up-a-specialized-maternity-unit-in-a-tertiary-hospital-an-oasis-for-pregnant-women-with-covid-19-during-the-pandemic
#11
JOURNAL ARTICLE
Ming-Ta Chuang, Yu-Ling Liang, Ta-Sheng Chen, Hsing-Fen Tsai, Pei-Ying Wu, Po-Fan Chen, Chiung-Hsin Chang, Lin Kang, Mei-Tsz Su, Yu-Ting Tien, Keng-Fu Hsu, Wen-Chien Ko, Meng-Ru Shen, Pei-Yin Tsai
OBJECTIVE: The COVID-19 pandemic has had an enormous impact on society and the medical environment in Taiwan in 2022. As pregnant women with COVID-19 are at higher risk for multiple complications, Taiwan needs a COVID-19 specialized maternity unit to improve the quality of maternal and neonatal care. MATERIALS AND METHODS: We share our experience with specialized maternity unit for pregnant women with COVID-19 at the National Cheng Kung University Hospital, where we can have careful evaluation, safe birth, and comprehensive postpartum care...
November 2023: Taiwanese Journal of Obstetrics & Gynecology
https://read.qxmd.com/read/37954082/dna-damage-repair-mutations-in-pancreatic-cancer-prognostic-or-predictive
#12
Ya-Fei Hu, Hai-Jie Hu, Heng-Chung Kung, Tian-Run Lv, Jun Yu, Fu-Yu Li
OBJECTIVE: The efficacy of platinum-based chemotherapy (PtCh) for pancreatic cancer (PC) patients with DNA damage repair gene mutations (DDRm) compared to those without DDRm remains uncertain. METHODS: After a thorough database searching in PubMed, Embase, and Web of Science, a total of 19 studies that met all the inclusion criteria were identified. The primary outcomes were overall survival (OS) and progression-free survival (PFS) for PC patients with DDRm versus those without DDRm after PtCh...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37917174/in-situ-vaccination-via-tissue-targeted-cdc1-expansion-enhances-the-immunogenicity-of-chemoradiation-and-immunotherapy
#13
JOURNAL ARTICLE
Brandon Lam, Yu Jui Kung, John Lin, Ssu-Hsueh Tseng, Hsin-Fang Tu, Claire Huang, Brandon Lee, Esteban Velarde, Ya Chea Tsai, Rafael Villasmil, Sung Taek Park, Deyin Xing, Chien-Fu Hung, T-C Wu
Even with the prolific clinical use of next-generation cancer therapeutics, many tumors remain unresponsive or become refractory to therapy, creating a medical need. In cancer, DCs are indispensable for T cell activation, so there is a restriction on cytotoxic T cell immunity if DCs are not present in sufficient numbers in the tumor and draining lymph nodes to take up and present relevant cancer antigens. To address this bottleneck, we developed a therapeutic based on albumin fused with FMS-related tyrosine kinase 3 ligand (Alb-Flt3L) that demonstrated superior pharmacokinetic properties compared with Flt3L, including significantly longer half-life, accumulation in tumors and lymph nodes, and cross-presenting-DC expansion following a single injection...
January 2, 2024: Journal of Clinical Investigation
https://read.qxmd.com/read/37767136/seed-correlation-analysis-based-on-brain-region-activation-for-adhd-diagnosis-in-a-large-scale-resting-state-data-set
#14
JOURNAL ARTICLE
Tsung-Hao Hsieh, Fu-Zen Shaw, Chun-Chia Kung, Sheng-Fu Liang
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder of multifactorial pathogenesis, which is often accompanied by dysfunction in several brain functional connectivity. Resting-state functional MRI have been used in ADHD, and they have been proposed as a possible biomarker of diagnosis information. This study's primary aim was to offer an effective seed-correlation analysis procedure to investigate the possible biomarker within resting state brain networks as diagnosis information...
2023: Frontiers in Human Neuroscience
https://read.qxmd.com/read/37760959/the-efficacy-of-anthropometric-indicators-in-predicting-non-alcoholic-fatty-liver-disease-using-fibroscan-%C3%A2-cap-values-among-the-taiwanese-population
#15
JOURNAL ARTICLE
Meng-Szu Lee, Eva Belingon Felipe-Dimog, Jeng-Fu Yang, Yi-Yu Chen, Kuan-Ta Wu, Hsiang-Ju Kuo, Tzu-Chun Lin, Chao-Ling Wang, Meng-Hsuan Hsieh, Chia-Yi Lin, Batbold Batsaikhan, Chi-Kung Ho, Ming-Tsang Wu, Chia-Yen Dai
The controlled attenuation parameter (CAP) measurement obtained from FibroScan® is a low-risk method of assessing fatty liver. This study investigated the association between the FibroScan® CAP values and nine anthropometric indicators, including the abdominal volume index (AVI), body fat percentage (BFP), body mass index (BMI), conicity index (CI), ponderal index (PI), relative fat mass (RFM), waist circumference (WC), waist-hip ratio (WHR), and waist-to-height ratio (WHtR), and risk of non-alcoholic fatty liver disease (fatty liver)...
September 12, 2023: Biomedicines
https://read.qxmd.com/read/37747618/severity-of-fatty-liver-is-highly-correlated-with-the-risk-of-hypertension-and-diabetes-a-cross-sectional-and-longitudinal-cohort-study
#16
JOURNAL ARTICLE
Chin-I Shih, Kuan-Ta Wu, Meng-Hsuan Hsieh, Jeng-Fu Yang, Yi-Yu Chen, Wei-Lun Tsai, Wen-Chi Chen, Po-Cheng Liang, Yu-Ju Wei, Pei-Chien Tsai, Po-Yao Hsu, Ming-Yen Hsieh, Yi-Hung Lin, Tyng-Yuan Jang, Chih-Wen Wang, Ming-Lun Yeh, Chung-Feng Huang, Jee-Fu Huang, Chia-Yen Dai, Chi-Kung Ho, Wan-Long Chuang, Ming-Lung Yu
BACKGROUND AND AIMS: Fatty liver disease (FLD) is associated with several metabolic derangements. We conducted a retrospective cross-sectional and longitudinal study to evaluate the role of FL severity in the risk of new-onset and co-existing hypertension (HTN) and diabetes mellitus (DM). METHODS: The cross-sectional cohort consisted of 41,888 adults who received health checkups in a tertiary hospital of Taiwan from 1999 to 2013. Of them, 34,865 without HTN and/or DM at baseline and within 1 year after enrollment were included as a longitudinal cohort (mean, 6...
September 25, 2023: Hepatology International
https://read.qxmd.com/read/37738363/regulatory-circuits-of-mitophagy-restrict-distinct-modes-of-cell-death-during-memory-cd8-t-cell-formation
#17
JOURNAL ARTICLE
Fabien Franco, Alessio Bevilacqua, Ruey-Mei Wu, Kung-Chi Kao, Chun-Pu Lin, Lorène Rousseau, Fu-Ti Peng, Yu-Ming Chuang, Jhan-Jie Peng, Jaeoh Park, Yingxi Xu, Antonino Cassotta, Yi-Ru Yu, Daniel E Speiser, Federica Sallusto, Ping-Chih Ho
Mitophagy, a central process guarding mitochondrial quality, is commonly impaired in human diseases such as Parkinson's disease, but its impact in adaptive immunity remains unclear. The differentiation and survival of memory CD8+ T cells rely on oxidative metabolism, a process that requires robust mitochondrial quality control. Here, we found that Parkinson's disease patients have a reduced frequency of CD8+ memory T cells compared with healthy donors and failed to form memory T cells upon vaccination against COVID-19, highlighting the importance of mitochondrial quality control for memory CD8+ T cell formation...
September 29, 2023: Science Immunology
https://read.qxmd.com/read/37711251/levels-of-organophosphate-flame-retardants-and-their-metabolites-among-391-volunteers-in-taiwan-difference-between-adults-and-children
#18
JOURNAL ARTICLE
Fu-Jen Cheng, Chih-Hwa Wang, Hsiu-Yung Pan, Chih-Cheng Chen, Wan-Ting Huang, Shau-Hsuan Li, Liang-Jen Wang, Chin-Chou Wang, Wen-Chin Lee, Kai-Fan Tsai, Yu-Che Ou, Chia-Te Kung
BACKGROUND: Organophosphate flame retardants (OPFRs) are ubiquitous in the environment. The compositions and concentrations of different OPFRs metabolites vary in different environments depending on different human activities. The objective of the present study was to evaluate the exposure of different age groups to OPFRs in Taiwan. METHODS: Volunteers provided urine samples and responded to questionnaires including demographic factors, underlying disease, lifestyle information, and occupation from October 2021 to January 2022...
2023: Frontiers in Public Health
https://read.qxmd.com/read/37688021/an-iot-sensing-platform-and-serious-game-for-remote-martial-arts-training
#19
JOURNAL ARTICLE
Karlos Ishac, Katia Bourahmoune, Marc Carmichael
We propose a system for self-supported martial arts training using an IoT sensing platform and Serious Game that can also be extended for general sports training. In martial arts, it is important that the practitioner is correctly performing each technique to accurately learn and prevent injury. A common stance in all martial arts, but especially in Shaolin Kung Fu, is the horse stance or Mabu. With the pandemic, many more people adopted remote training without the presence of a professional trainer to give advice...
August 31, 2023: Sensors
https://read.qxmd.com/read/37640197/engineered-tcr-t-cell-therapy-targeting-mass-spectrometry-identified-natural-epitope-in-pdac
#20
JOURNAL ARTICLE
Jianxin Wang, Tengyi Zhang, Pan Li, Jessica Gai, Sophia Chen, Gigi Espinoza, Heng-Chung Kung, Rui Zhang, Kenji Fujiwara, Juan Fu, Jun Yu, Lei Zheng
Tumor antigens are crucial targets for T-cell-based therapy to induce tumor-specific rejection. However, identifying pancreatic ductal adenocarcinoma (PDAC)-specific T-cell epitopes has been challenging. Using advanced mass spectrometry (MS) analysis, we previously identified cancer-associated, class I MHC-bound epitopes shared by multiple PDAC patients with different HLA-A types. Here, we investigated one of these epitopes, LAMC2203-211 , a naturally occurring nonmutated epitope on the LAMC2 protein. Following stimulation with the LAMC2203-211 peptide, we cloned T-cell receptors (TCRs) and transduced them into the Jurkat human T-cell line using a lentiviral vector...
August 26, 2023: Cancer Letters
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