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https://www.readbyqxmd.com/read/27859216/cooperation-of-mll-af10-om-lz-with-ptpn11-activating-mutation-induced-monocytic-leukemia-with-a-shorter-latency-in-a-mouse-bone-marrow-transplantation-model
#1
Jen-Fen Fu, Sung-Tzu Liang, Ying-Jung Huang, Kung-Hao Liang, Tzung-Hai Yen, Der-Cherng Liang, Lee-Yung Shih
PTPN11 mutation, a RAS signaling pathway mutation, is associated with MLL translocations in acute leukemia. A girl with MLL/AF10 AML was found to carry PTPN11(G503A) . To study the impact of PTPN11 (G503A) cooperating with MLL/AF10 on leukemogenesis, we established a retroviral transduction/transplantation mouse model. Compared with the MLL/AF10(OM-LZ) leukemia cells harboring PTPN11 (wt) , the cells harboring PTPN11(G503A) were hypersensitive to GM-CSF and IL3, and more resistant to death upon treatment with daunorubicin but sensitive to cytarabine...
November 14, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27813227/mir-34a-modulates-erbb2-in-breast-cancer
#2
Yilin Wang, Xiaolong Zhang, Zou Chao, Hsiang-Fu Kung, Marie C Lin, Andreas Dress, Fiona Wardle, Bing-Hua Jiang, Lihui Lai
Breast cancer is the second highest cause of carcinoma-related death caused by distant metastasis in women. Estrogen receptor (ER), human epidermal growth factor receptor 2, (HER2) and progesterone receptor (PR) are three classified makers of breast cancer, which are defined as ER+, HER2+, and the most serious ER-PR-HER2- (triple-negative). It is well known that ErbB2 (V-Erb-B2 avian erythroblastic leukemia viral oncogene homolog 2) plays an important part in breast cancer. However, the molecular mechanisms underlying ErbB2 action needs to be well studied...
November 4, 2016: Cell Biology International
https://www.readbyqxmd.com/read/27766260/the-prognosis-of-cardiac-origin-and-noncardiac-origin-in-hospital-cardiac-arrest-occurring-during-night-shifts
#3
Yuan-Jhen Syue, Jyun-Bin Huang, Fu-Jen Cheng, Chia-Te Kung, Chao-Jui Li
Background. The survival rates of in-hospital cardiac arrests (IHCAs) are reportedly low at night, but the difference between the survival rates of cardiac origin and noncardiac origin IHCAs occurring at night remains unclear. Methods. Outcomes of IHCAs during different shifts (night, day, and evening) were compared and stratified according to the etiology (cardiac and noncardiac origin). Result. The rate of return of spontaneous circulation (ROSC) was 24.7% lower for cardiac origin IHCA and 19.4% lower for noncardiac origin IHCA in the night shift than in the other shifts...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27754332/tetrandrine-induces-apoptosis-of-human-nasopharyngeal-carcinoma-npc-tw-076-cells-through-reactive-oxygen-species-accompanied-by-an-endoplasmic-reticulum-stress-signaling-pathway
#4
Ya-Jing Lin, Shu-Fen Peng, Meng-Liang Lin, Chao-Lin Kuo, Kung-Wen Lu, Ching-Lung Liao, Yi-Shih Ma, Fu-Shin Chueh, Kuo-Ching Liu, Fu-Shun Yu, Jing-Gung Chung
Nasopharyngeal carcinoma (NPC) is an epithelial malignancy of the head and neck and the incidence is higher in Southeast Asia. Tetrandrine (TET) is a bisbenzylisoquinoline alkaloid, a natural product, and exhibits biological activities including action against many human cancer cell lines. However, the molecular mechanism of TET-induced cell apoptosis in human NPC cells is still unclear. In the present study, we investigated TET-induced apoptotic cell death and associated possible signal pathways on human nasopharyngeal carcinoma NPC-TW 076 cells in vitro...
October 12, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27751415/validation-of-the-traditional-chinese-version-of-the-prolapse-quality-of-life-questionnaire-p-qol-in-a-mandarin-speaking-taiwanese-population
#5
Fei-Chi Chuang, Li-Ching Chu, Fu-Tsai Kung, Kuan-Hui Huang
OBJECTIVE: To validate the traditional Chinese translated version of the prolapse quality of life questionnaire (P-QOL). MATERIALS AND METHODS: The P-QOL questionnaire was translated into traditional Chinese characters and administered to women recruited from gynecologic outpatient clinics of Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan. After the test-retest reliability and internal consistency were established in a pilot study, all participants completed the P-QOL questionnaire and were examined in the lithotomy position using the Pelvic Organ Prolapse Quantification System (POP-Q)...
October 2016: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27742031/distinct-subpopulations-of-hepatitis-c-virus-infectious-cells-with-different-levels-of-intracellular-hepatitis-c-virus-core-protein
#6
Shu-Chi Wang, Jeng-Fu Yang, Chao-Ling Wang, Chung-Feng Huang, Yu-Yin Lin, Yi-You Chen, Chung-Ting Lo, Po-Yen Lee, Kuan-Ta Wu, Chia-I Lin, Meng-Hsuan Hsieh, Hung-Yi Chuang, Chi-Kung Ho, Ming-Lung Yu, Chia-Yen Dai
Chronic infection by hepatitis C virus (HCV) is a major risk factor for the development of hepatocellular carcinoma (HCC). Despite the clear clinical importance of virus-associated HCC, the underlying molecular mechanisms remain largely unclarified. Oxidative stress, in particular, DNA lesions associated with oxidative damage, plays a major role in carcinogenesis, and is strongly linked to the development of many cancers, including HCC. However, in identifying hepatocytes with HCV viral RNA, estimates of the median proportion of HCV-infected hepatocytes have been found as high as 40% in patients with chronic HCV infection...
October 2016: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/27726326/achieving-low-energy-driven-viologens-based-electrochromic-devices-utilizing-polymeric-ionic-liquids
#7
Hsin-Che Lu, Sheng-Yuan Kao, Hsin-Fu Yu, Ting-Hsiang Chang, Chung-Wei Kung, Kuo-Chuan Ho
Herein, three kinds of viologens-based electrochromic devices (ECDs) (heptyl viologen (HV(BF4)2), octyl viologen (OV(BF4)2), and nonyl viologen (NV(BF4)2)) were fabricated utilizing ferrocene (Fc) as a redox mediator. Among them, the NV(BF4)2-based ECD exhibits the highest coloration efficiency (36.2 cm2/C) owing to the lowest driving energy. Besides, switching between 0 and 1.2 V, the NV(BF4)2-based ECD shows a desirable initial transmittance change (∆T = 56.7% at 605 nm), and long-term stability (∆T = 45...
October 11, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27714998/prominent-vascularization-capacity-of-mesenchymal-stem-cells-in-collagen-gold-nanocomposites
#8
Shuchen Hsieh, Hui-Jye Chen, Shan-Hui Hsu, Yi-Chun Yang, Cheng-Ming Tang, Mei-Yun Chu, Pei-Ying Lin, Ru-Huei Fu, Mei-Lang Kung, Yun-Wen Chen, Bi-Wen Yeh, Huey-Shan Hung
The ideal characteristics of surface modification on the vascular graft for clinical application would be with excellent hemocompatibility, endothelialization capacity, and anti-restenosis ability. Here, Fourier transform infrared spectroscopy (FTIR), surface enhanced raman spectroscopy (SERS), atomic force microscopy (AFM), contact angle () measurement, and thermogravimetric analyzer (TGA) were used to evaluate the chemical and mechanical properties of collagen-gold nanocomposites (collagen+Au) with 17...
October 7, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27676825/isokinetic-strength-trunk-assessment-of-athletes
#9
Amira Zouita Ben Moussa
OBJECTIVE: Sport specific consideration, different demands of various sports and specific training reveal differences of trunk strength capacity. The purpose of this study was to identify strength firstly characteristics of isokinetic parameters of trunk of athletes and secondary to detect the difference and the effect of sports. MATERIAL/PATIENTS AND METHODS: Sixteen athletes of national team athletes were recruited for the study: weightlifting and wrestlers to participate in this study...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27664399/in-silico-prediction-and-in-vitro-and-in-vivo-validation-of-acaricide-fluazuron-as-a-potential-inhibitor-of-fgfr3-and-a-candidate-anticancer-drug-for-bladder-carcinoma
#10
Kunbin Ke, Hongjian Li, Hong Yao, Xi-Nan Shi, Chao Dong, Ying Zhu, Xu Liu, Ling Li, Kwong-Sak Leung, Man-Hon Wong, Xiao-Dong Liu, Hsiang-Fu Kung, Marie Chia-Mi Lin
Bladder carcinoma (BC) is the 9(th) most common cause of cancer worldwide. Surgical resection and conventional chemotherapy and radiotherapy will ultimately fail due to tumor recurrence and resistance. Thus, the development of novel treatment is urgently needed. Fibroblast growth factor receptor 3 (FGFR3) is an important and well-established target for BC treatment. In this study, we utilized the free and open-source protein-ligand docking software idock to prospectively identify potential inhibitors of FGFR3 from 3167 worldwide approved small-molecule drugs using a repositioning strategy...
September 24, 2016: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/27659552/transcatheter-arterial-embolization-as-first-line-rescue-in-intractable-primary-postpartum-hemorrhage-assessment-outcome-and-subsequent-fertility
#11
Hsin-Hsin Cheng, Leo Leung-Chit Tsang, Te-Yao Hsu, Chia-Te Kung, Chia-Yu Ou, Ching-Di Chang, Ching-Chang Tsai, Yu-Fan Cheng, Fu-Tsai Kung
BACKGROUND/PURPOSE: To assess the risk factors for intractable and controllable postpartum hemorrhage (PPH) and to evaluate the safety, efficacy, and outcome of transcatheter arterial embolization (TAE). METHODS: An emergency PPH rescue system including the 24-hour-available TAE was established in 2004. TAE with gelatine sponge particles placed on bilateral uterine or internal iliac arteries served as the first-line treatment for intractable PPH. Delivery methods, parity, causes of bleeding, clinical vital signs, coagulopathy, success rate, resumption of menstruation, and subsequent pregnancy outcome after TAE were recorded...
September 19, 2016: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/27450026/comparison-of-the-clinical-outcomes-of-transobturator-and-single-incision-slings-for%C3%A2-stress%C3%A2-urinary-incontinence
#12
Ling-Ying Wu, Tsai-Hwa Yang, Fu-Tsai Kung, Fei-Chi Chuang, Kuan-Hui Huang
The aim of this study was to compare the clinical outcomes of anti-incontinence surgeries employing the transobturator sling and single-incision sling (SIS). Our hypothesis is that the outcome of the SIS is not inferior to the obturator sling. This retrospective study reviewed the medical records of patients who underwent anti-incontinence surgery with the transobturator sling or SIS from July 2005 to November 2014. Patients who underwent concomitant pelvic organ reconstruction with an artificial mesh were excluded...
July 2016: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/27409345/loss-of-myc-and-e-box3-binding-contributes-to-defective-myc-mediated-transcriptional-suppression-of-human-mc-let-7a-1-let-7d-in-glioblastoma
#13
Zifeng Wang, Sheng Lin, Ji Zhang, Zhenhua Xu, Yu Xiang, Hong Yao, Lei Ge, Dan Xie, Hsiang-Fu Kung, Gang Lu, Wai Sang Poon, Quentin Liu, Marie Chia-Mi Lin
Previously, we reported that MYC oncoprotein down-regulates the transcription of human MC-let-7a-1~let-7d microRNA cluster in hepatocarcinoma (HCC). Surprisingly, in silico analysis indicated that let-7 miRNA expression levels are not reduced in glioblastoma (GBM). Here we investigated the molecular basis of this differential expression. Using human GBM U87 and U251 cells, we first demonstrated that forced over-expression of MYC indeed could not down-regulate the expression of human MC-let-7a-1~let-7d microRNA cluster in GBM...
July 9, 2016: Oncotarget
https://www.readbyqxmd.com/read/27343327/prenatal-diagnosis-of-mosaic-small-supernumerary-marker-chromosome-17-associated-with-ventricular-septal-defect-developmental-delay-and-speech-delay
#14
Chih-Ping Chen, Sheng Chiang, Kung-Liahng Wang, Fu-Nan Cho, Ming Chen, Schu-Rern Chern, Peih-Shan Wu, Yen-Ni Chen, Shin-Wen Chen, Shun-Ping Chang, Weu-Lin Chen, Wayseen Wang
OBJECTIVE: We present molecular cytogenetic characterization of mosaic small supernumerary marker chromosome (sSMC) derived from chromosome 17. MATERIALS AND METHODS: A 43-year-old woman underwent amniocentesis at 17 weeks of gestation because of advanced maternal age. Amniocentesis revealed a karyotype of 47,XY,+mar[12]/46,XY[15]. Parental karyotypes were normal. Array comparative genomic hybridization (aCGH) and metaphase fluorescence in situ hybridization (FISH) were applied on cultured amniocytes...
June 2016: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27343311/efficacy-of-femarelle-for-the-treatment-of-climacteric-syndrome-in-postmenopausal-women-an-open-label-trial
#15
Fang-Ping Chen, Chee Jen Chang, An-Shine Chao, Hong-Yuan Huang, Jian-Pei Huang, Meng-Hsing Wu, Ching-Chou Tsai, Fu-Tsai Kung, Ching-Wen Chang, Yung-Chieh Tsai
OBJECTIVE: To assess the effects of 2 months of treatment with Femarelle for climacteric syndrome in Taiwanese postmenopausal women. MATERIALS AND METHODS: A multi-center, open-label trial of 260 postmenopausal women, age ≥ 45 years with vasomotor symptoms. Women were enrolled after obtaining a detailed medical history and a thorough physical examination. They then received Femarelle (640 mg/d) twice daily for 8 weeks. The primary outcome was the changes in the frequency and severity of hot flushes from baseline to 4 weeks (1 month) and 8 weeks (2 months)...
June 2016: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27260673/inhibition-by-ketamine-and-amphetamine-analogs-of-the-neurogenic-nitrergic-vasodilations-in-porcine-basilar-arteries
#16
Mei-Fang Chen, Su-Yu Lai, Po-Cheng Kung, Yo-Cheng Lin, Hui-I Yang, Po-Yi Chen, Ingrid Y Liu, Ahai Chang Lua, Tony Jer-Fu Lee
The abuse of ketamine and amphetamine analogs is associated with incidence of hypertension and strokes involving activation of sympathetic activities. Large cerebral arteries at the base of the brain from several species receive dense sympathetic innervation which upon activation causes parasympathetic-nitrergic vasodilation with increased regional blood flow via axo-axonal interaction mechanism, serving as a protective mechanism to meet O2 demand in an acutely stressful situation. The present study was designed to examine effects of ketamine and amphetamine analogs on axo-axonal interaction-mediated neurogenic nitrergic vasodilation in porcine basilar arteries using techniques of blood-vessel myography, patch clamp and two-electrode voltage clamp, and calcium imaging...
August 15, 2016: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/27203100/converting-nonliquid-crystals-into-liquid-crystals-by-n-methylation-in-the-central-linker-of-triazine-based-dendrimers
#17
Meng-Jung Tsai, Jei-Way Hsieh, Long-Li Lai, Kung-Lung Cheng, Shih-Hsien Liu, Jey-Jau Lee, Hsiu-Fu Hsu
Two triazine-based dendrimers were successfully prepared in 60-75% yields. These newly prepared dendrimers 2a and 2b containing the -NMe(CH2)2NMe- and the -NMe(CH2)4NMe- linkers between two G3 dendrons, respectively, exhibit columnar phases during the thermal process. However, the corresponding dendrimers 1a and 1b containing the -NH(CH2)2NH- and the -NH(CH2)4NH- linkers between two G3 dendrons, respectively, do not show any LC phases on thermal treatment. Computational investigations on molecular conformations reveal that N-methylation of the dendritic central linker leads dendrimers to possess more isomeric conformations and thus successfully converts non-LC dendrimers (1a and 1b) into LC dendrimers (2a and 2b)...
June 17, 2016: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/27133044/mir-195-inhibits-tumor-growth-and-angiogenesis-through-modulating-irs1-in-breast-cancer
#18
Yilin Wang, Xiaolong Zhang, Chao Zou, Hsiang-Fu Kung, Marie C Lin, Andreas Dress, Fiona Wardle, Bing-Hua Jiang, Lihui Lai
Angiogenesis has been found as an attractive target for drug therapy as it is necessary for tumor growth. Accumulating evidences show that microRNAs (miRNAs), which are a group of highly conserved, single-stranded, short non-coding RNAs, play important roles through directly targeting angiogenic factors and protein kinases. The purpose of this study is to investigate the role of miR-195 in breast cancer development and angiogenesis through targeting IRS1. We show that miR-195 is inversely related with Insulin receptor substrate 1 (IRS1) in both breast cancer cells and breast cancer tissues...
May 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27028992/the-putative-tumor-activator-arhgef3-promotes-nasopharyngeal-carcinoma-cell-pathogenesis-by-inhibiting-cellular-apoptosis
#19
Tian-Hao Liu, Fang Zheng, Mu-Yan Cai, Lin Guo, Huan-Xin Lin, Jie-Wei Chen, Yi-Ji Liao, Hsiang-Fu Kung, Yi-Xin Zeng, Dan Xie
Nasopharyngeal carcinoma (NPC) is one of the most prevalent forms of highly invasive malignancy in Southern China and Southeast Asia. The pathogenesis of NPC is a multistep process driven by the acquisition of numerous genetic abnormalities. We investigated the potential oncogenic role of the Rho-guanine nucleotide exchange factor 3 gene, ARHGEF3, in NPC pathogenesis. Expression levels of ARHGEF3 were frequently up-regulated in NPC cell lines and tissues. In a large cohort of clinical NPC tissues high expression of ARHGEF3 was positively associated with an increased T status, distant metastasis, and a more advanced clinical stage (P < 0...
May 3, 2016: Oncotarget
https://www.readbyqxmd.com/read/27017002/-practice-of-martial-arts-and-bone-mineral-density-in-adolescents-of-both-sexes
#20
Igor Hideki Ito, Alessandra Madia Mantovani, Ricardo Ribeiro Agostinete, Paulo Costa Junior, Edner Fernando Zanuto, Diego Giulliano Destro Christofaro, Luis Pedro Ribeiro, Rômulo Araújo Fernandes
OBJECTIVE: The purpose of this study was to analyze the relationship between martial arts practice (judo, karate and kung-fu) and bone mineral density in adolescents. METHODS: The study was composed of 138 (48 martial arts practitioners and 90 non-practitioners) adolescents of both sexes, with an average age of 12.6 years. Bone mineral density was measured using Dual-Energy X-ray Absorptiometry in arms, legs, spine, trunk, pelvis and total. Weekly training load and previous time of engagement in the sport modality were reported by the coach...
June 2016: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
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