Esten H Leonardsen, Didac Vidal-Piñeiro, James M Roe, Oleksandr Frei, Alexey A Shadrin, Olena Iakunchykova, Ann-Marie G de Lange, Tobias Kaufmann, Bernd Taschler, Stephen M Smith, Ole A Andreassen, Thomas Wolfers, Lars T Westlye, Yunpeng Wang
The difference between chronological age and the apparent age of the brain estimated from brain imaging data-the brain age gap (BAG)-is widely considered a general indicator of brain health. Converging evidence supports that BAG is sensitive to an array of genetic and nongenetic traits and diseases, yet few studies have examined the genetic architecture and its corresponding causal relationships with common brain disorders. Here, we estimate BAG using state-of-the-art neural networks trained on brain scans from 53,542 individuals (age range 3-95 years)...
May 10, 2023: Molecular Psychiatry