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Electroconvulsive schizophrenia immunology

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https://www.readbyqxmd.com/read/26663628/acute-psychosis-due-to-non-paraneoplastic-anti-nmda-receptor-encephalitis-in-a-teenage-girl-case-report
#1
Sandra Kramina, Laura Kevere, Nikita Bezborodovs, Santa Purvina, Guntis Rozentals, Jurgis Strautmanis, Zane Viksna
Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis is a disease occurring when antibodies produced by the body's own immune system attack NMDA-type glutamate receptors in the brain. Most anti-NMDAR encephalitis cases are associated with paraneoplastic syndrome. We analyze the case of a 15-year-old girl who was hospitalized in a child psychiatry clinic in Riga, Latvia, with de novo acute polymorphic psychotic disorder gradually progressing to a catatonic state. The patient received antipsychotic and electroconvulsive therapy with no beneficial effect...
December 2015: PsyCh Journal
https://www.readbyqxmd.com/read/18537668/cox-2-inhibition-in-schizophrenia-and-major-depression
#2
REVIEW
Norbert Müller, Markus J Schwarz
In schizophrenia and depression, opposite patterns of type-1 - type-2 immune response seem to be associated with differences in the activation of the enzyme indoleamine 2,3-dioxygenase (IDO) and in the tryptophan - kynurenine metabolism resulting in increased production of kynurenic acid in schizophrenia and decreased production of kynurenic acid in depression. These differences are associated with an imbalance in the glutamatergic neurotransmission, which may contribute to an overweight of N-methyl-D-aspartate (NMDA) agonism in depression and of NMDA antagonism in schizophrenia...
2008: Current Pharmaceutical Design
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