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https://www.readbyqxmd.com/read/28937601/humoral-response-of-buffaloes-to-a-recombinant-vaccine-against-botulism-serotypes-c-and-d
#1
Denis Y Otaka, José D Barbosa, Clóvis Moreira, Marcos R A Ferreira, Carlos E P Cunha, Antônio R S Brito, Rafael A Donassolo, Ângela N Moreira, Fabrício R Conceição, Felipe M Salvarani
Botulism is a fatal intoxication caused by botulinum neurotoxins (BoNTs), which are mainly produced by Clostridium botulinum and characterized by flaccid paralysis. The BoNTs C and D are the main serotypes responsible for botulism in animals, including buffaloes. Botulism is one of the leading causes of death in adult ruminants in Brazil due to the high mortality rates, even though botulism in buffaloes is poorly reported and does not reflect the real economic impact of this disease in Brazilian herds. Vaccination is reported as the most important prophylactic measure for botulism control, although there are no specific vaccines commercially available for buffaloes in Brazil...
September 22, 2017: Toxins
https://www.readbyqxmd.com/read/28929089/two-novel-salmonella-bivalent-vaccines-confer-dual-protection-against-two-salmonella-serovars-in-mice
#2
Xinxin Zhao, Qinlong Dai, Renyong Jia, Dekang Zhu, Mafeng Liu, Mingshu Wang, Shun Chen, Kunfeng Sun, Qiao Yang, Ying Wu, Anchun Cheng
Non-typhoidal Salmonella includes thousands of serovars that are leading causes of foodborne diarrheal illness worldwide. In this study, we constructed three bivalent vaccines for preventing both Salmonella Typhimurium and Salmonella Newport infections by using the aspartate semialdehyde dehydrogenase (Asd)-based balanced-lethal vector-host system. The constructed Asd(+) plasmid pCZ11 carrying a subset of the Salmonella Newport O-antigen gene cluster including the wzx-wbaR-wbaL-wbaQ-wzy-wbaW-wbaZ genes was introduced into three Salmonella Typhimurium mutants: SLT19 (Δasd) with a smooth LPS phenotype, SLT20 (Δasd ΔrfbN) with a rough LPS phenotype, and SLT22 (Δasd ΔrfbN ΔpagL::T araC PBADrfbN) with a smooth LPS phenotype when grown with arabinose...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28928748/a-peptide-fc-opsonin-with-pan-amyloid-reactivity
#3
James S Foster, Angela D Williams, Sallie Macy, Tina Richey, Alan Stuckey, Daniel Craig Wooliver, Richa Koul-Tiwari, Emily B Martin, Stephen J Kennel, Jonathan S Wall
There is a continuing need for therapeutic interventions for patients with the protein misfolding disorders that result in systemic amyloidosis. Recently, specific antibodies have been employed to treat AL amyloidosis by opsonizing tissue amyloid deposits thereby inducing cell-mediated dissolution and organ improvement. To develop a pan-amyloid therapeutic agent, we have produced an Fc-fusion product incorporating a peptide, p5, which binds many if not all forms of amyloid. This protein, designated Fcp5, expressed in mammalian cells, forms the desired bivalent dimer structure and retains pan-amyloid reactivity similar to the p5 peptide as measured by immunosorbent assays, immunohistochemistry, surface plasmon resonance, and pulldown assays using radioiodinated Fcp5...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28926080/polio-n%C3%A3-rmar-sig-utrotning
#4
Erling Norrby, Ingrid Uhnoo, Mia Brytting, Katherina Zakikhany, Tiia Lepp, Patrick Olin
Polio close to eradication The WHO Global Polio Eradication Initiative has been highly successful. With a dramatic decrease in polio since it started in 1988, the number of globally reported cases reached a record low of 37 in 2016. This article describes the WHO Endgame Strategic Plan including milestones that have been reached and challenges that have to be overcome in order to reach the goal of polio eradication by 2020. Efforts to strengthen immunizations systems and to detect and interrupt polio virus transmission focus on the three remaining endemic countries, namely Pakistan, Afghanistan and Nigeria...
September 19, 2017: Läkartidningen
https://www.readbyqxmd.com/read/28925965/studying-the-structural-significance-of-galectin-design-by-playing-a-modular-puzzle-homodimer-generation-from-human-tandem-repeat-type-heterodimeric-galectin-8-by-domain-shuffling
#5
Anna-Kristin Ludwig, Malwina Michalak, Nadya Shilova, Sabine André, Herbert Kaltner, Nicolai V Bovin, Jürgen Kopitz, Hans-Joachim Gabius
Tissue lectins are emerging (patho)physiological effectors with broad significance. The capacity of adhesion/growth-regulatory galectins to form functional complexes with distinct cellular glycoconjugates is based on molecular selection of matching partners. Engineering of variants by changing the topological display of carbohydrate recognition domains (CRDs) provides tools to understand the inherent specificity of the functional pairing. We here illustrate its practical implementation in the case of human tandem-repeat-type galectin-8 (Gal-8)...
September 19, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28923849/bivalent-epigenetic-control-of-oncofetal-gene-expression-in-cancer
#6
Sayyed K Zaidi, Seth E Frietze, Jonathan A Gordon, Jessica L Heath, Terri Messier, Deli Hong, Joseph R Boyd, Mingu Kang, Anthony N Imbalzano, Jane B Lian, Janet L Stein, Gary S Stein
Multiple mechanisms of epigenetic control that include DNA methylation, histone modification, non-coding RNAs, and mitotic gene bookmarking play pivotal roles in stringent gene regulation during lineage commitment and maintenance. Experimental evidence indicates that bivalent chromatin domains, i.e., regions of genome that are marked by both H3K4me3 (activating) and H3K27me3 (repressive) histone modifications, are a key property of pluripotent stem cells. Bivalency of developmental genes during the G1 phase of the pluripotent stem cell cycle contributes to cell fate decisions...
September 18, 2017: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/28919959/chromosome-mapping-in-abracris-flavolineata-de-geer-1773-orthoptera-from-the-igua%C3%A3-u-national-park-foz-do-igua%C3%A3-u-paran%C3%A3-brazil
#7
Mariana Bozina Pine, Raquel Bozini Gallo, Carlos Roberto Maximiano da Silva, Larissa Forim Pezenti, Fernando Campos De Domenico, Vilma Loreto, Renata da Rosa
In this paper, we present the cytomolecular analysis of a population of Abracris flavolineata collected in the largest fragment of the Brazilian Atlantic forest, the Iguaçu National Park. The diploid number in males was 23 (22+X0), with two large pairs (1-2), 7 medium (3-9), 2 small (10-11) and the X chromosome of medium size. Heterochromatic blocks were evident in the pericentromeric regions of all chromosomes. Heterogeneity in the distribution of heterochromatin was observed, with a predominance of DAPI(+) blocks...
2017: Comparative Cytogenetics
https://www.readbyqxmd.com/read/28919954/immunocytological-analysis-of-meiotic-recombination-in-two-anole-lizards-squamata-dactyloidae
#8
Artem P Lisachov, Vladimir A Trifonov, Massimo Giovannotti, Malcolm A Ferguson-Smith, Pavel M Borodin
Although the evolutionary importance of meiotic recombination is not disputed, the significance of interspecies differences in the recombination rates and recombination landscapes remains under-appreciated. Recombination rates and distribution of chiasmata have been examined cytologically in many mammalian species, whereas data on other vertebrates are scarce. Immunolocalization of the protein of the synaptonemal complex (SYCP3), centromere proteins and the mismatch-repair protein MLH1 was used, which is associated with the most common type of recombination nodules, to analyze the pattern of meiotic recombination in the male of two species of iguanian lizards, Anolis carolinensis Voigt, 1832 and Deiroptyx coelestinus (Cope, 1862)...
2017: Comparative Cytogenetics
https://www.readbyqxmd.com/read/28916764/rapid-and-reversible-epigenome-editing-by-endogenous-chromatin-regulators
#9
Simon M G Braun, Jacob G Kirkland, Emma J Chory, Dylan Husmann, Joseph P Calarco, Gerald R Crabtree
Understanding the causal link between epigenetic marks and gene regulation remains a central question in chromatin biology. To edit the epigenome we developed the FIRE-Cas9 system for rapid and reversible recruitment of endogenous chromatin regulators to specific genomic loci. We enhanced the dCas9-MS2 anchor for genome targeting with Fkbp/Frb dimerizing fusion proteins to allow chemical-induced proximity of a desired chromatin regulator. We find that mSWI/SNF (BAF) complex recruitment is sufficient to oppose Polycomb within minutes, leading to activation of bivalent gene transcription in mouse embryonic stem cells...
September 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/28913864/strand-displacement-in-coiled-coil-structures-controlled-induction-and-reversal-of-proximity
#10
Katharina Gröger, Georgina Gavins, Oliver Seitz
Coiled-coil peptides are frequently used to create new function upon self-assembly of supramolecular complexes. A multitude of coil peptide sequences provides control over specificity and stability of coiled-coil complexes. However, comparably little attention has been paid to the development of methods that allow for the reversal of complex formation under non-denaturing conditions. Herein, we present a reversible 2-state switching system. The process involves two peptide molecules for formation of a size-mismatched coiled-coil duplex and a third, disruptor peptide which targets an overhanging end...
September 15, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28911838/efficacy-of-a-single-oral-dose-of-a-live-bivalent-e-coli-vaccine-against-post-weaning-diarrhea-due-to-f4-and-f18-positive-enterotoxigenic-e-coli
#11
É Nadeau, J M Fairbrother, J Zentek, L Bélanger, D Tremblay, C-L Tremblay, I Röhe, W Vahjen, M Brunelle, K Hellmann, D Cvejić, B Brunner, C Schneider, K Bauer, R Wolf, Á Hidalgo
F4- and F18-positive enterotoxigenic E. coli strains (F4-ETEC and F18-ETEC) are important causes of post-weaning diarrhea (PWD) in pigs. F4 (antigenic variant ac) and F18 (ab and ac) fimbriae are major antigens that play an important role in the early stages of infection. Herein, the efficacy of a live oral vaccine consisting of two non-pathogenic E. coli strains, one F4ac- and one F18ac-positive, was evaluated using F4ac-ETEC and F18ab-ETEC challenge models. A randomized, masked, placebo-controlled, block design, parallel-group confirmatory study with two different vaccination-challenge intervals (7 and 21 days) was conducted for each challenge model...
August 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28910563/safety-and-immunogenicity-of-the-killed-bivalent-o1-and-o139-whole-cell-cholera-vaccine-in-the-philippines
#12
Maria Rosario Z Capeding, Maria Liza Antoinette M Gonzales, Mandeep Singh Dhingra, Naveena Aloysia D'cor, Venkat Jayanth Midde, Badri Narayan Patnaik, Yaël Thollot, Eric Desauziers
The killed bivalent (O1 and O139) whole cell oral cholera vaccine (OCV) (Shanchol™) was first licensed in India in 2009 and World Health Organization pre-qualified in 2011. We assessed the safety and immunogenicity of this OCV in the Philippines. This was a phase IV, single-arm, descriptive, open-label study. We recruited 336 participants from two centers: 112 participants in each age group (1-4, 5-14 and ≥15 years). Participants received two OCV doses 14 days apart. Safety was monitored throughout the trial...
September 14, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28902178/tumor-inhibitory-effect-of-ircr201-a-novel-cross-reactive-c-met-antibody-targeting-the-psi-domain
#13
Hyunkyu Park, Donggeon Kim, Eunmi Kim, Jason K Sa, Hee Won Lee, Suji Yu, Jiwon Oh, Seok-Hyung Kim, Yeup Yoon, Do-Hyun Nam
Hepatocyte growth factor receptor (HGFR, c-Met) is an essential member of the receptor tyrosine kinase (RTK) family that is often dysregulated during tumor progression, driving a malignant phenotypic state and modulating important cellular functions including tumor growth, invasion, metastasis, and angiogenesis, providing a strong rationale for targeting HGF/c-Met signaling axis in cancer therapy. Based on its protumorigenic potentials, we developed IRCR201, a potent antagonistic antibody targeting the plexin-semaphorin-integrin (PSI) domain of c-Met, using synthetic human antibody phage libraries...
September 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28899625/cost-effectiveness-of-hpv-vaccination-in-the-context-of-high-cervical-cancer-incidence-and-low-screening-coverage
#14
Triin Võrno, Katrin Lutsar, Anneli Uusküla, Lee Padrik, Terje Raud, Rainer Reile, Oliver Nahkur, Raul-Allan Kiivet
BACKGROUND: Estonia has high cervical cancer incidence and low screening coverage. We modelled the impact of population-based bivalent, quadrivalent or nonavalent HPV vaccination alongside cervical cancer screening. METHODS: A Markov cohort model of the natural history of HPV infection was used to assess the cost-effectiveness of vaccinating a cohort of 12-year-old girls with bivalent, quadrivalent or nonavalent vaccine in two doses in a national, school-based vaccination programme...
September 9, 2017: Vaccine
https://www.readbyqxmd.com/read/28891868/a-bivalent-ligand-that-activates-mu-opioid-receptor-and-antagonizes-mglur5-receptor-reduces-neuropathic-pain-in-mice
#15
Cristina D Peterson, Kelley F Kitto, Eyup Akgün, Mary M Lunzer, Maureen S Riedl, Lucy Vulchanova, George L Wilcox, Philip S Portoghese, Carolyn A Fairbanks
The mu opioid receptor (MOR) and metabotropic glutamate receptor 5 (mGluR5) are well-established pharmacological targets in the management of chronic pain. Both receptors are expressed in spinal cord. MMG22, a bivalent ligand containing two pharmacophores separated by 22 atoms that simultaneously activates MOR and antagonizes mGluR5 has been shown to produce potent reversal of tactile hypersensitivity in rodent models of LPS- and bone-cancer-induced chronic pain. The present study assessed whether intrathecal MMG22 also is effective in reducing pain of neuropathic origin...
September 1, 2017: Pain
https://www.readbyqxmd.com/read/28887213/bivalent-mucosal-peptide-vaccines-administered-using-the-lcp-carrier-system-stimulate-protective-immune-responses-against-streptococcus-pyogenes-infection
#16
Kai Schulze, Thomas Ebensen, Saranya Chandrudu, Mariusz Skwarczynski, Istvan Toth, Colleen Olive, Carlos A Guzman
Despite the broad knowledge about the pathogenicity of Streptococcus pyogenes there is still a controversy about the correlate of protection in GAS infections. We aimed in further improving the immune responses stimulated against GAS comparing different vaccine formulations including bis-(3',5')-cyclic dimeric adenosine monophosphate (c-di-AMP) and BPPCysMPEG, a derivative of the macrophage-activating lipopeptide (MALP-2), as adjuvants, respectively, to be administered with and without the universal T helper cell epitope P25 along with the optimized B cell epitope J14 of the M protein and B and T cell epitopes of SfbI...
September 5, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28886152/molecular-cytogenetic-identification-of-a-novel-wheat-agropyron-elongatum-chromosome-translocation-line-with-powdery-mildew-resistance
#17
Xiaojun Li, Xiaoling Jiang, Xiangdong Chen, Jie Song, Cuicui Ren, Yajuan Xiao, Xiaohui Gao, Zhengang Ru
Agropyron elongatum (Host.) Neviski (synonym, Thinopyrum ponticum Podp., 2n = 70) has been used extensively as a valuable source for wheat breeding. Numerous chromosome fragments containing valuable genes have been successfully translocated into wheat from A. elongatum. However, reports on the transfer of powdery mildew resistance from A. elongatum to wheat are rare. In this study, a novel wheat-A. elongatum translocation line, 11-20-1, developed and selected from the progenies of a sequential cross between wheat varieties (Lankaoaizaoba, Keyu 818 and BainongAK 58) and A...
2017: PloS One
https://www.readbyqxmd.com/read/28881547/-health-economic-evaluation-of-bivalent-human-papilloma-virus-vaccine-in-china-based-on-the-dynamic-model
#18
X B Song, Q J Zhao, Z Zhou, Y Fang
Objective: This study aims to evaluate the prevention effect and cost-effectiveness of a prophylactic bivalent human papilloma virus (HPV) vaccine. Methods: A multiple health status dynamic model was developed, including natural history of diseases and prevention strategies. We built 19 prevention strategies including visual inspection with acetic acid/lugol's iodine (VIA/VILI) and/or 3 does prophylactic bivalent HPV vaccine administered to adolescent girls at the age of 15 years old every year under the assumption that vaccine coverage and screening coverage were 70%...
September 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28880717/bivalent-histone-codes-on-wnt5a-during-odontogenic-differentiation
#19
Y Zhou, L Zheng, F Li, M Wan, Y Fan, X Zhou, W Du, C Pi, D Cui, B Zhang, J Sun, X Zhou
Lineage-committed differentiation is an essential biological program during odontogenesis, which is tightly regulated by lineage-specific genes. Some of these genes are modified by colocalization of H3K4me3 and H3K27me3 marks at promoter regions in progenitors. These modifications, named "bivalent domains," maintain genes in a poised state and then resolve for later activation or repression during differentiation. Wnt5a has been reported to promote odontogenic differentiation in dental mesenchyme. However, relatively little is known about the epigenetic modulations on Wnt5a activation during tooth development...
September 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28878573/cost-effectiveness-of-human-papillomavirus-vaccination-in-germany
#20
Oliver Damm, Johannes Horn, Rafael T Mikolajczyk, Mirjam E E Kretzschmar, Andreas M Kaufmann, Yvonne Deleré, Bernhard Ultsch, Ole Wichmann, Alexander Krämer, Wolfgang Greiner
BACKGROUND: The aim of this study was to assess the cost-effectiveness of human papillomavirus (HPV) vaccination in addition to the current cervical cancer screening programme in Germany using a dynamic transmission model. METHODS: Based on a mathematical model simulating the transmission dynamics and the natural history of HPV infection and associated diseases (cervical intraepithelial neoplasia, cervical cancer, and genital warts), we estimated the epidemiological and economic consequences of HPV vaccination with both the quadrivalent and bivalent vaccines...
2017: Cost Effectiveness and Resource Allocation: C/E
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