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https://www.readbyqxmd.com/read/28102546/ataluren-and-similar-compounds-specific-therapies-for-premature-termination-codon-class-i-mutations-for-cystic-fibrosis
#1
REVIEW
Aisha A Aslam, Colin Higgins, Ian P Sinha, Kevin W Southern
BACKGROUND: Cystic fibrosis is a common life-shortening genetic disorder in the Caucasian population (less common in other ethnic groups) caused by the mutation of a single gene that codes for the production of the cystic fibrosis transmembrane conductance regulator protein. This protein coordinates the transport of salt (and bicarbonate) across cell surfaces and the mutation most notably affects the airways. In the lungs of people with cystic fibrosis, defective protein results in a dehydrated surface liquid and compromised mucociliary clearance...
January 19, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28096006/immunizations-challenge-healthcare-personnel-and-affects-immunization-rates
#2
Pamela K Strohfus, Susan C Kim, Sara Palma, Russell A Duke, Richard Remington, Caleb Roberts
PURPOSE: This study measured 1. medical office immunization rates and 2. health care personnel competency in managing vaccine practices before and after evidence-based immunization education was provided. METHOD: This descriptive study compared 32 family medicine and pediatric offices and 178 medical assistants, licensed practical nurses, registered nurses, nurse practitioners, and physicians in knowledge-based testing pre-education, post-education, and 12-months post-education...
February 2017: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/28091446/correlation-between-athlete-training-intensity-and-cardiac-performance
#3
T Xiao, Y Zhang
OBJECTIVE: An effective analysis of correlation between training intensity of athletes and cardiac performance is done to develop scientific and reasonable exercise program and to promote health of athletes. METHODS: During December 2013-December 2015, 3600 students from different sports schools were selected for the test. All the athletes were randomly grouped, that is half-hour running group, one-hour running group and 90 -minute running group, which are named A, B, C groups respectively...
February 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28089838/quality-of-reporting-randomized-controlled-trials-in-five-leading-neurology-journals-in-2008-and-2013-using-the-modified-risk-of-bias-tool
#4
Xiao Zhai, Jin Cui, Yiran Wang, Zhiquan Qu, Qingchun Mu, Peiwen Li, Chaochao Zhang, Mingyuan Yang, Xiao Chen, Ziqiang Chen, Ming Li
BACKGROUND: To examine the risk of bias of methodological quality of reporting randomized clinical trials (RCTs) in major neurology journals before and after the updation (2011) of Cochrane risk of bias tool. METHODS: RCTs in five leading neurology journals in 2008 and 2013 were searched systematically. Characteristics were extracted based on the list of the modified Cochrane Collaboration's tool. Country, number of patients, type of intervention and funding source were also revealed for further analysis...
January 9, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28088557/meta-analysis-of-organizational-skills-interventions-for-children-and-adolescents-with-attention-deficit-hyperactivity-disorder
#5
REVIEW
Aida Bikic, Brian Reichow, Spencer A McCauley, Karim Ibrahim, Denis G Sukhodolsky
BACKGROUND: In addition to problems with attention and hyperactivity, children with ADHD present with poor organizational skills required for managing time and materials in academic projects. Organizational skills training (OST) has been increasingly used to address these deficits. We conducted a systematic review and meta-analysis of OST in children with ADHD. OBJECTIVES: The objective of this study was to systematically review the evidence of the effects of OST for children with ADHD for organizational skills, attention, and academic performance...
December 29, 2016: Clinical Psychology Review
https://www.readbyqxmd.com/read/28071983/what-does-leaders-character-add-to-transformational-leadership
#6
Patrick Liborius
The influence of leaders' character (e.g., integrity, humility/forgiveness) has rarely been examined in leadership research. The current investigation focused on the impact of integrity and humility/forgiveness on both followers' perceptions of leaders' worthiness of being followed (WBF) and stress. Results from a scenario experiment (n = 347) and a field study (n = 110) indicated that these aspects incrementally predict WBF above and beyond the impact of transformational leadership. Similar results were found concerning followers' stress with the exception of leader integrity in the field study...
January 10, 2017: Journal of Psychology
https://www.readbyqxmd.com/read/28066881/short-acting-erythropoiesis-stimulating-agents-for-anaemia-in-predialysis-patients
#7
REVIEW
Deirdre Hahn, Christopher I Esezobor, Noha Elserafy, Angela C Webster, Elisabeth M Hodson
BACKGROUND: The benefits of erythropoiesis-stimulating agents (ESA) for chronic kidney disease (CKD) patients have been previously demonstrated. However, the efficacy and safety of short-acting epoetins administered at larger doses and reduced frequency as well as of new epoetins and biosimilars remains uncertain. OBJECTIVES: This review aimed to evaluate the benefits and harms of different routes, frequencies and doses of epoetins (epoetin alpha, epoetin beta and other short-acting epoetins) for anaemia in adults and children with CKD not receiving dialysis...
January 9, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28065328/use-of-personal-protective-equipment-among-health-care-personnel-results-of-clinical-observations-and-simulations
#8
JaHyun Kang, John M O'Donnell, Bonnie Colaianne, Nicholas Bircher, Dianxu Ren, Kenneth J Smith
BACKGROUND: Very little is known about how health care personnel (HCP) actually use personal protective equipment (PPE). METHODS: The clinical PPE practices of 50 HCP from selected units at the University of Pittsburgh Medical Center (UPMC) Presbyterian Hospital were videotaped with HCP consent. For 2 PPE simulation sessions (simple and full-body sets), 82 HCP were recruited throughout the UPMC system. Simulation practices were videotaped and examined using fluorescent powder with ultraviolet lighting...
January 1, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28054197/comparing-the-costs-and-acceptability-of-three-fidelity-assessment-methods-for-assertive-community-treatment
#9
Angela L Rollins, Marina Kukla, Michelle P Salyers, John H McGrew, Mindy E Flanagan, Doug L Leslie, Marcia G Hunt, Alan B McGuire
Successful implementation of evidence-based practices requires valid, yet practical fidelity monitoring. This study compared the costs and acceptability of three fidelity assessment methods: on-site, phone, and expert-scored self-report. Thirty-two randomly selected VA mental health intensive case management teams completed all fidelity assessments using a standardized scale and provided feedback on each. Personnel and travel costs across the three methods were compared for statistical differences. Both phone and expert-scored self-report methods demonstrated significantly lower costs than on-site assessments, even when excluding travel costs...
January 4, 2017: Administration and Policy in Mental Health
https://www.readbyqxmd.com/read/28050999/retaining-health-workforce-in-rural-and-underserved-areas-of-india-what-works-and-what-doesn-t-a-critical-interpretative-synthesis
#10
REVIEW
Sonu Goel, Federica Angeli, Nidhi Bhatnagar, Neetu Singla, Manoj Grover, Hans Maarse
BACKGROUND: Human resource for health is critical in quality healthcare delivery. India, with a large rural population (68.8%), needs to urgently bridge the gaps in health workforce deployment between urban and rural areas. METHODS: We did a critical interpretative synthesis of the existing literature by using a predefined selection criteria to assess relevant manuscripts to identify the reasons for retaining the health workforce in rural and underserved areas. We discuss different strategies for retention of health workforce in rural areas on the basis of four major retention interventions, viz...
July 2016: National Medical Journal of India
https://www.readbyqxmd.com/read/28046987/su-f-p-10-a-web-based-radiation-safety-relational-database-module-for-regulatory-compliance
#11
C Rosen, B Ramsay, S Konerth, D Roller, A Ramsay
PURPOSE: Maintaining compliance with Radioactive Materials Licenses is inherently a time-consuming task requiring focus and attention to detail. Staff tasked with these responsibilities, such as the Radiation Safety Officer and associated personnel must retain disparate records for eventual placement into one or more annual reports. Entering results and records in a relational database using a web browser as the interface, and storing that data in a cloud-based storage site, removes procedural barriers...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28043024/utility-of-a-questionnaire-tool-quaras-for-localizing-and-lateralizing-seizures-in-the-epilepsy-monitoring-unit-emu
#12
Rima M Chaudhari, Bhargavi Ramanujam, Renjith Appukuttan, Anubha Sharma, Yuvraj Kunwar, Gaurav Tejaniya, Ajay Garg, Madakasira Vasantha Padma, Madhavi Tripathi, Chandrashekhar Bal, Deepa Dash, Sarat P Chandra, Manjari Tripathi
OBJECTIVES: An accurate description of the seizure semiology improves the recognition of the ictal onset zone and helps in hypothesizing the possible epileptogenic zone (EZ). Semiology based on a reliable description of seizures may be as good as investigative modalities, as has been shown by numerous studies. The main objective of this study was to apply a questionnaire-tool for auras and semiology (QUARAS) in refractory epilepsy cohort and compare its yield to that of standard history-taking...
December 22, 2016: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28012709/the-history-and-challenges-of-blood-donor-screening-in-china
#13
REVIEW
Ling Li, Ka Yi Li, Ke Yan, Guojin Ou, Wenhui Li, Jue Wang, Ning Song, Li Tian, Xin Ji, Yongjun Chen, Xiaohua Liang, Zhong Liu, Yanyun Wu
Since the establishment of People's Republic of China in 1949, the Chinese government has encountered several catastrophes related to transfusion transmitted diseases. The government's increasing attention to blood safety has prompted the initiation of a series of policies and measures that have enhanced the level of safety for the blood supply and met the basic clinical demands of blood for 1.3 billion people in the country. Blood donation screening strategies in China predominantly comprise donor screening and donor testing...
November 12, 2016: Transfusion Medicine Reviews
https://www.readbyqxmd.com/read/28004190/systematic-review-of-the-implementation-of-simulation-training-in-surgical-residency-curriculum
#14
REVIEW
Yo Kurashima, Satoshi Hirano
PURPOSE: We reviewed the literature regarding the specific methods and strategies for implementing simulation-based training into the modern surgical residency curriculum. Residency programs are still struggling with how best to implement it into their curricula from a practical viewpoint. METHODS: A systematic review was performed using Ovid MEDLINE, EMBASE, PubMed, PsycINFO, Web of Science, and other resources for studies involving the use of simulation for technical skills training in the surgical residency curriculum...
December 22, 2016: Surgery Today
https://www.readbyqxmd.com/read/28003834/discharge-against-medical-advice-at-neonatal-intensive-care-unit-in-gujarat-india
#15
Bhanu Devpura, Pranav Bhadesia, Somashekhar Nimbalkar, Sandeep Desai, Ajay Phatak
Objective. We explored reasons for discharged against medical advice (DAMA) of neonates from a neonatal intensive care unit (NICU) through in-depth interviews of the parents/guardians. Methods. Of 456 babies admitted to NICU during April 2014 to March 2015, 116 babies were DAMA. Parents of randomly selected 50 babies of these 116, residing within 50 kilometers, were approached for in-depth interviews at their homes. Audio recordings were done and manually transcribed, analyzed in detail to explore common threads leading to DAMA...
2016: International Journal of Pediatrics
https://www.readbyqxmd.com/read/27997928/development-and-validation-of-the-motivations-for-selection-of-medical-study-msms-questionnaire-in-india
#16
Sonu Goel, Federica Angeli, Neetu Singla, Dirk Ruwaard
BACKGROUND AND OBJECTIVE: Understanding medical students' motivation to select medical studies is particularly salient to inform practice and policymaking in countries-such as India-where shortage of medical personnel poses crucial and chronical challenges to healthcare systems. This study aims to develop and validate a questionnaire to assess the motivation of medical students to select medical studies. METHODS: A Motivation for Selection of Medical Study (MSMS) questionnaire was developed using extensive literature review followed by Delphi technique...
2016: PloS One
https://www.readbyqxmd.com/read/27986232/the-need-for-formal-surgical-global-health-programs-and-improved-mission-trip-coordination
#17
Sar Medoff, Jeffrey Freed
BACKGROUND: There is a dire need for more surgical services as part of improving global health. Conditions treatable with surgery account for 11% of the global burden of disease, with a disproportionate burden affecting low- and middle-income countries (LMICs). Less than 6% of the world's operations are performed in LMICs, with relief organizations performing nearly 250,000 operations annually in LMICs in addition to each country's domestic surgical capacity. Currently, surgical needs are not adequately met by the existing patchwork of federal and nongovernmental organizations' surgical services and surgical mission trips...
July 2016: Annals of Global Health
https://www.readbyqxmd.com/read/27982007/motivational-interviewing-in-general-dental-practice-a-review-of-the-evidence
#18
E J Kay, D Vascott, A Hocking, H Nield
Objectives The objective of this study was to systematically review the evidence regarding the use of motivational interviewing in the context of general dental practice, in order that practitioners can decide whether it might be an important skill to develop within their practices.Data sources The results reported in this study form part of a larger systematic review which sought to identify whether oral health promotion within dental practice is effective and how its effects can be optimised. Here, we focus on the papers describing motivational interviewing in dental practice published since 1994...
December 16, 2016: British Dental Journal
https://www.readbyqxmd.com/read/27974145/head-lice
#19
Laura Meister, Falk Ochsendorf
BACKGROUND: Conflicting information about the proper treatment of head lice has given rise to uncertainty among patients and treating personnel. For example, the reported efficacy of permethrin fell from 97% in the 1990s to 30% in 2010. METHODS: Review of the literature based on a selective search of PubMed. RESULTS: In Germany, outbreaks of head lice mainly occur among 5- to 13-year-olds returning to school after the summer vacation. Nymphs hatch from eggs after an average of 8 days and become sexually mature lice over the ensuing 9 days...
November 11, 2016: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/27941193/comparison-of-72-hour-fecal-fat-quantification-and-the-13c-mixed-triglyceride-breath-test-in-assessing-pancreatic-exocrine-sufficiency-in-children-with-chronic-pancreatitis
#20
Karolina Wejnarska, Elwira Kołodziejczyk, Józef Ryżko, Grzegorz Oracz
INTRODUCTION: Chronic pancreatitis (CP) in children is still a rare, although increasingly recognized entity. Over the duration of the disease several complications can be observed, two of which are major ones: endo- and exocrine insufficiency. In the medical care of children with CP it is crucial to diagnose the decreased endo- and exocrine function of the pancreas, in order to preserve patients from malnutrition and the failure to thrive. The aim of the study was to compare the usefulness of two indirect methods of assessing the pancreas exocrine function in children with CP...
2016: Developmental Period Medicine
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