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https://www.readbyqxmd.com/read/29214596/preparing-for-the-future-of-rare-diseases
#1
Stephen C Groft, Manuel Posada de la Paz
Members of the rare disease community have devoted significant financial and personnel resources to address the numerous issues surrounding rare diseases. The past has been devoted to developing an emphasis on rare diseases including an emphasis on research studies or locating information on rare diseases and the requirements and limitations of conducting clinical trials with small patient populations. The expanded role of patient advocacy organizations and patient engagement in all aspects of clinical research continues to gain acceptance within the research community...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29209790/-delegation-of-medical-activities-in-acute-pain-therapy
#2
REVIEW
J Erlenwein, A Moroder, E Biermann, F Petzke, A P F Ehlers, H Bitter, E Pogatzki-Zahn
Acute pain management is an interprofessional and interdisciplinary task and requires a good and trustful cooperation between stakeholders. Despite provisions in Germany according to which medical treatment can only be rendered by a formally qualified physician ("Arztvorbehalt"), a physician does not have to carry out every medical activity in person. Under certain conditions, some medical activities can be delegated to medical auxiliary personnel but they need to be (1) instructed, (2) supervised and (3) checked by the physician himself; however, medical history, diagnostic assessment and evaluation, indications, therapy planning (e...
December 5, 2017: Der Anaesthesist
https://www.readbyqxmd.com/read/29202630/concurrent-new-drug-prescriptions-and-prognosis-of-early-breast-cancer-studies-using-the-danish-breast-cancer-group-clinical-database
#3
Deirdre Cronin-Fenton, Timothy L Lash, Thomas P Ahern, Per Damkier, Peer Christiansen, Bent Ejlertsen, Henrik T Sørensen
BACKGROUND: Myriad reports suggest that frequently used prescription drugs alter the viability of breast cancer cells in pre-clinical studies. Routine use of these drugs, therefore, may impact breast cancer prognosis, and could have important implications for public health. METHODS: The Danish Breast Cancer Group (DBCG) clinical database provides high-quality prospectively collected data on breast cancer diagnosis, treatment, and routine follow-up for breast cancer recurrence...
December 5, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29201360/are-physician-assistant-and-patient-airway-assessments-reliable-compared-to-anesthesiologist-assessments-in-detecting-difficult-airways-in-general-surgical-patients
#4
Erin Payne, Jacqueline Ragheb, Elizabeth S Jewell, Betsy P Huang, Angela M Bailey, Laura M Fritsch, Milo Engoren
Background: Airway management remains one of the most important responsibilities of anesthesiologists. Prediction of difficult airway allows time for proper selection of equipment, technique, and personnel experienced in managing patients with difficult airway. Face to face preoperative anesthesia interviews are difficult to conduct as they necessitate patients traveling to the clinics, and, in practice, are usually conducted in the morning of the procedure by the anesthesiologist, when identification of predictors of difficult intubation may lead to schedule delays or case cancelations...
2017: Perioperative Medicine
https://www.readbyqxmd.com/read/29199043/evaluating-interest-in-an-influenza-a-h5n1-vaccine-among-laboratory-workers-who-work-with-highly-pathogenic-avian-influenza-viruses-in-the-united-states
#5
Kate E Russell, J S Bresee, J M Katz, S J Olsen
BACKGROUND: Highly pathogenic avian influenza A (HPAI) viruses found in poultry and wild birds occasionally infect humans and can cause serious disease. In 2014, the Advisory Committee on Immunization Practices (ACIP) reviewed data from one licensed ASO3-adjuvanted influenza A(H5N1) vaccine for consideration of use during inter-pandemic periods among persons with occupational exposure. To guide vaccine policy decisions, we conducted a survey of laboratory workers to assess demand for HPAI vaccination...
November 30, 2017: Vaccine
https://www.readbyqxmd.com/read/29197180/acupuncture-for-neuropathic-pain-in-adults
#6
REVIEW
Zi Yong Ju, Ke Wang, Hua Shun Cui, Yibo Yao, Shi Min Liu, Jia Zhou, Tong Yu Chen, Jun Xia
BACKGROUND: Neuropathic pain may be caused by nerve damage, and is often followed by changes to the central nervous system. Uncertainty remains regarding the effectiveness and safety of acupuncture treatments for neuropathic pain, despite a number of clinical trials being undertaken. OBJECTIVES: To assess the analgesic efficacy and adverse events of acupuncture treatments for chronic neuropathic pain in adults. SEARCH METHODS: We searched CENTRAL, MEDLINE, Embase, four Chinese databases, ClinicalTrials...
December 2, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29193997/predicting-airport-screening-officers-visual-search-competency-with-a-rapid-assessment
#7
Stephen R Mitroff, Justin M Ericson, Benjamin Sharpe
Objective The study's objective was to assess a new personnel selection and assessment tool for aviation security screeners. A mobile app was modified to create a tool, and the question was whether it could predict professional screeners' on-job performance. Background A variety of professions (airport security, radiology, the military, etc.) rely on visual search performance-being able to detect targets. Given the importance of such professions, it is necessary to maximize performance, and one means to do so is to select individuals who excel at visual search...
November 1, 2017: Human Factors
https://www.readbyqxmd.com/read/29185018/evaluation-of-resources-necessary-for-provision-of-trauma-care-in-botswana-an-initiative-for-a-local-system
#8
Michael B Mwandri, Timothy C Hardcastle
BACKGROUND: Developing countries face the highest incidence of trauma, and on the other hand, they do not have resources for mitigating the scourge of these injuries. The World Health Organization through the Essential Trauma Care (ETC) project provides recommendations for improving management of the injured and building up of systems that are effective in low-middle-income countries (LMICs). This study uses ETC project recommendations and other trauma-care guidelines to evaluate the current status of the resources and organizational structures necessary for optimal trauma care in Botswana; an African country with relatively good health facilities network, subsidized public hospital care and a functioning Motor Vehicle Accident fund covering road traffic collision victims...
November 28, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29178172/anti-adhesion-therapy-following-operative-hysteroscopy-for-treatment-of-female-subfertility
#9
REVIEW
Jan Bosteels, Steven Weyers, Thomas M D'Hooghe, Helen Torrance, Frank J Broekmans, Su Jen Chua, Ben Willem J Mol
BACKGROUND: Observational evidence suggests a potential benefit with several anti-adhesion therapies in women undergoing operative hysteroscopy (e.g. insertion of an intrauterine device or balloon, hormonal treatment, barrier gels or human amniotic membrane grafting) for decreasing intrauterine adhesions (IUAs). OBJECTIVES: To assess the effectiveness of anti-adhesion therapies versus placebo, no treatment or any other anti-adhesion therapy, following operative hysteroscopy for treatment of female subfertility...
November 27, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29173627/correlation-between-slaughter-practices-and-the-distribution-of-salmonella-and-hygiene-indicator-bacteria-on-pig-carcasses-during-slaughter
#10
W Biasino, L De Zutter, W Mattheus, S Bertrand, M Uyttendaele, I Van Damme
This study investigated the distribution of hygiene indicator bacteria and Salmonella on pig carcasses. Moreover, the relation between hygiene indicator counts and Salmonella presence as well as associations between specific slaughter practices and carcass contamination were determined for each carcass area. Seven Belgian pig slaughterhouses were visited three times to swab five randomly selected carcasses at nine different areas, after evisceration and trimming. Information about slaughter practices was collected using a questionaire...
April 2018: Food Microbiology
https://www.readbyqxmd.com/read/29172011/therapy-and-rehabilitation-of-mild-brain-injury-concussion-systematic-review
#11
Roger E Thomas, Jorge Alves, Marcus M Vaska Mlis, Rosana Magalhaes
BACKGROUND: Assessment of therapies for the key consequences of mild traumatic brain injury (mTBI)/concussion is required. OBJECTIVE: Identify all RCTs of mTBI/concussion therapy, risks of bias, and therapies with significant positive results. METHODS: 17 electronic, 9 grey-literature databases searched without language/date restrictions; independent assessment of 1450 Abstracts/titles, 141 fulltext articles, 14 included RCTs. RESULTS: Four RCTs used American Congress of Rehabilitation TBI definition, others used unique definitions...
2017: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/29168550/aed-use-in-public-places-a-study-of-acquisition-time
#12
Wojciech Telec, Artur Baszko, Marek Dabrowski, Agata Dabrowska, Maciej Sip, Mateusz Puslecki, Tomasz Klosiewicz, Patrycja Potyrala, Witold Jurczyk, Adrian Maciejewski, Radoslaw Zalewski, Magdalena Witt, Jerzy Robert Ladny, Lukasz Szarpak
BACKGROUND: Sudden cardiac arrest (SCA) is a frequent cause of death in the developed world. Early defibrillation, preferably within the first minutes of the incident, significantly increases survival rates. Accessible automated external defibrillators (AED) in public areas have been promoted for many years and several locations are equipped with these devices. AIM: The aim of the study was to assess real-life availability of AEDs and assess possible sources of delay...
November 23, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/29157037/fetal-nuchal-translucency-in-severe-congenital-heart-defects-experiences-in-northern-finland
#13
Julia Alanen, Markku Leskinen, Mikko Sairanen, Teemu Korpimaki, Heikki Kouru, Mika Gissler, Markku Ryynanen, Jaana Nevalainen
OBJECTIVE: To evaluate the performance of first trimester measurement of fetal nuchal translucency (NT) in detection of severe congenital heart defects (CHDs). METHODS: During the study period of 1.1.2008 - 31.12.2011 NT was measured in 31 144 women as a part of voluntary first trimester screening program for Down's syndrome in Northern Finland. NT was measured by personnel trained on the job by experienced staff. No certification or annual audits are required in Finland...
November 20, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29149879/risk-management-of-emergency-service-vehicle-crashes-in-the-united-states-fire-service-process-outputs-and-recommendations
#14
David P Bui, Keshia P Porter, Stephanie Griffin, Dustin D French, Alesia M Jung, Stephen Crothers, Jefferey L Burgess
BACKGROUND: Emergency service vehicle crashes (ESVCs) are a leading cause of death in the United States fire service. Risk management (RM) is a proactive process for identifying occupational risks and reducing hazards and unwanted events through an iterative process of scoping hazards, risk assessment, and implementing controls. We describe the process, outputs, and lessons learned from the application of a proactive RM process to reduce ESVCs in US fire departments. METHODS: Three fire departments representative of urban, suburban, and rural geographies, participated in a facilitated RM process delivered through focus groups and stakeholder discussion...
November 17, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29149116/solving-the-problem-of-smoking-in-the-polish-enterprises-during-2003-2015
#15
Elżbieta Korzeniowska, Krzysztof Puchalski
OBJECTIVES: Tobacco smoking is a major organizational, economical, and public relations-related (PR-related) problem for the company. Moreover, it is an important health determinant of the working population. The paper reports the results of the research which analyzed the current state and the tobacco control activities' transformations undertaken by Polish employers between 2003 and 2015. MATERIAL AND METHODS: Data comes from the research performed in 2006, 2010 and 2015, involving random- selected representative samples of Polish enterprises, employing no fewer than 50 employees...
November 17, 2017: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/29145584/critical-lessons-from-high-value-oncology-practices
#16
Douglas W Blayney, Melora K Simon, Beatrice Podtschaske, Scott Ramsey, Margaret Shyu, Craig Lindquist, Arnold Milstein
Importance: Cancer care is expensive. Cancer care provided by practice organizations varies in total spending incurred by patients and payers during treatment episodes and in quality of care, and this unnecessary variation contributes to the high cost. Objective: To use the variation in total spending and quality of care to assess oncology practice attributes distinguishing "high value" that may be tested and adopted by others to produce similar results. Design, Setting, and Participants: "Positive deviance" was used in this exploratory mixed-methods (quantitative and qualitative) analysis of interview results...
November 16, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/29137508/health-professional-education-and-universal-health-coverage-a-summary-of-challenges-and-selected-case-studies
#17
Arthika Sripathy, Joachim Marti, Hannah Patel, Javaid I Sheikh, Ara W Darzi
Low- and middle-income countries are experiencing serious shortages in meeting health workforce requirements for universal health coverage. We examine how national-level policies can address these deficiencies and support the development of an appropriately skilled health workforce in line with population needs. We discuss three innovative, government-led solutions that are designed to align health workforce training with the demands of universal health coverage. Specifically, we discuss two initiatives to train and retain doctors in rural areas of Thailand, the large-scale training of community health workers within multidisciplinary primary health care teams in Brazil, and the introduction of a postgraduate diploma program in primary care for nurses in India...
November 2017: Health Affairs
https://www.readbyqxmd.com/read/29116007/prevalence-of-bartonella-spp-by-culture-pcr-and-serology-in-veterinary-personnel-from-spain
#18
José A Oteo, Ricardo Maggi, Aránzazu Portillo, Julie Bradley, Lara García-Álvarez, Montserrat San-Martín, Xavier Roura, Edward Breitschwerdt
BACKGROUND: The genus Bartonella includes fastidious, facultative intracellular bacteria mainly transmitted by arthropods and distributed among mammalian reservoirs. Bartonella spp. implicated as etiological agents of zoonoses are increasing. Apart from the classical Bartonella henselae, B. bacilliformis or B. quintana, other species (B. elizabethae, B. rochalimae, B. vinsonii arupensis and B. v. berkhoffii, B. tamiae or B. koehlerae, among others) have also been associated with human and/or animal diseases...
November 7, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29114262/in-depth-analysis-of-the-leading-causes-of-maternal-mortality-due-to-cesarean-section-in-iran
#19
Nasrin Changizi, Golnaz Rezaeizadeh, Leila Janani, Mamak Shariat, Abbas Habibelahi
Objective: Despite the declining trend of maternal mortality (MMR) in Iran between 1990 and 2013, direct causes are still the major reasons for maternal death. One of these direct causes is complications of cesarean section (CS). Since the rate of CS in Iran is quite high (47.9%) and the trend continues to rise, there is an alarming threat of the possibility of increasing MMR in the country as a result of cesarean section complications, especially in repeated cases. In this study, we attempted to determine the indications of CS in reported maternal mortality, with special attention to risk factors predisposing to CS and/or to maternal mortality...
March 2017: Journal of Family & Reproductive Health
https://www.readbyqxmd.com/read/29112126/factors-that-influence-linkages-to-hiv-continuum-of-care-services-implications-for-multi-level-interventions
#20
Rogério M Pinto, Susan S Witte, Prema L Filippone, Karen L Baird, Wendy R Whitman
Worldwide, the human immunodeficiency virus (HIV) continuum of care involves health promotion providers (e.g., social workers and health educators) linking patients to medical personnel who provide HIV testing, primary care, and antiretroviral treatments. Regrettably, these life-saving linkages are not always made consistently and many patients are not retained in care. To design, test and implement effective interventions, we need to first identify key factors that may improve linkage-making. To help close this gap, we used in-depth interviews with 20 providers selected from a sample of 250 participants in a mixed-method longitudinal study conducted in New York City (2012-2017) in order to examine the implementation of HIV services for at-risk populations...
November 7, 2017: International Journal of Environmental Research and Public Health
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