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https://www.readbyqxmd.com/read/28343293/pharmacokinetic-and-pharmacodynamic-considerations-in-the-treatment-of-chronic-lymphocytic-leukemia-ibrutinib-idelalisib-and-venetoclax
#1
REVIEW
Madeline Waldron, Allison Winter, Brian T Hill
Management of chronic lymphocytic leukemia has changed markedly over the last several years with the emergence of several novel oral agents targeting B-cell receptor and Bcl-2 signaling pathways. For patients requiring treatment, ibrutinib, idelalisib, and venetoclax offer unique clinical benefits with a different set of therapeutic considerations compared with traditional parenteral therapy. Despite the conveniences afforded by oral therapy, these agents also carry unique logistical obstacles. Drug interactions with agents that are metabolized via the cytochrome P450 3A4 pathway are possible with all three agents...
March 25, 2017: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/28343132/probing-polarity-of-flame-retardants-and-correlating-with-interaction-between-flame-retardants-and-pet-fiber
#2
Shuo Chang, Xiang Zhou, Zhiqi Xing, Tianmin Tu
The empirical polarity parameter ET(30) was determined for polyethylene terephthalate (PET) fiber and five phosphorus flame retardants by UV-Vis absorption spectrum of solvatochromic probe. To investigate the interaction between flame retardant and PET fiber during the finishing process, the partition coefficients K of these flame retardants between water and PET fiber were determined and an interesting linear relationship between lnK and ET(30) of the flame retardants was obtained, suggesting ET(30) is definitely an excellent estimation of the interaction of flame retardants with PET...
March 11, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28342852/effects-of-sub-culturing-on-genetic-and-physiological-parameters-in-different-beauveria-bassiana-isolates
#3
Naser Eivazian Kary, Zhila Alizadeh
Beauveria bassiana is a fungus which is widely used as a biological insecticide to control a number of economically important insect pests. Knowledge of the genetic diversity of the isolates, understanding the underlying nature of these evolutionary phenomena and finding appropriate and simple screening tools play an important role in developing effective biocontrol agents. Here, we monitored changes of electrophoretic karyotype of small molecules of extrachromosomal DNAs, presumably mitochondrial DNA or plasmids in several individual isolates of B...
March 22, 2017: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/28342764/ketamine-as-a-rapid-acting-agent-for-suicidal-ideation-a-meta-analysis
#4
REVIEW
Francesco Bartoli, Ilaria Riboldi, Cristina Crocamo, Carmen Di Brita, Massimo Clerici, Giuseppe Carrà
The current systematic review and meta-analysis aimed at exploring acute effects of intravenous (IV) ketamine, an antagonist of N-methyl-D-aspartate (NMDA), in subjects with current suicidal ideation. We included clinical trials testing a single IV dose of ketamine and assessing changes in suicidal ideation within 4hours after treatment. Meta-analyses based on random-effects models, were carried out generating pooled standardized mean differences (SMDs) between endpoint and baseline scores. Heterogeneity among studies was estimated using the I(2) index...
March 22, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28342705/comparison-of-20-mannitol-and-3-hypertonic-saline-on-intracranial-pressure-and-systemic-hemodynamics
#5
Navdeep Sokhal, Girija Prasad Rath, Arvind Chaturvedi, Manmohan Singh, Hari Hara Dash
Mannitol and hypertonic saline (HS) are most commonly used hyperosmotic agents for intraoperative brain relaxation. We compared the changes in ICP and systemic hemodynamics after infusion of equiosmolar solutions of both agents in patients undergoing craniotomy for supratentorial tumors. Forty enrolled adults underwent a standard anesthetic induction. Apart from routine monitoring parameters, subdural ICP with Codmann catheter and cardiac indices by Vigileo monitor, were recorded. The patients were randomized to receive equiosmolar solutions of either 20% mannitol (5ml/kg) or 3% HS (5...
March 22, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28342661/climate-change-and-human-infectious-diseases-a-synthesis-of-research-findings-from-global-and-spatio-temporal-perspectives
#6
Lu Liang, Peng Gong
The life cycles and transmission of most infectious agents are inextricably linked with climate. In spite of a growing level of interest and progress in determining climate change effects on infectious disease, the debate on the potential health outcomes remains polarizing, which is partly attributable to the varying effects of climate change, different types of pathogen-host systems, and spatio-temporal scales. We summarize the published evidence and show that over the past few decades, the reported negative or uncertain responses of infectious diseases to climate change has been growing...
March 22, 2017: Environment International
https://www.readbyqxmd.com/read/28342561/a-strategic-document-as-a-tool-for-implementing-change-lessons-from-the-merger-creating-the-south-east-health-region-in-norway
#7
Tarald Rohde, Hans Torvatn
In 2007, the Norwegian Parliament decided to merge the two largest health regions in the country: the South and East Health Regions became the South-East Health Region (SEHR). In its resolution, the Parliament formulated strong expectations for the merger: these included more effective hospital services in the Oslo metropolitan area, freeing personnel to work in other parts of the country, and making treatment of patients more coherent. The Parliamentary resolution provided no specific instructions regarding how this should be achieved...
March 6, 2017: Health Policy
https://www.readbyqxmd.com/read/28342350/challenges-for-tree-officers-to-enhance-the-provision-of-regulating-ecosystem-services-from-urban-forests
#8
Helen J Davies, Kieron J Doick, Malcolm D Hudson, Kate Schreckenberg
Urbanisation and a changing climate are leading to more frequent and severe flood, heat and air pollution episodes in Britain's cities. Interest in nature-based solutions to these urban problems is growing, with urban forests potentially able to provide a range of regulating ecosystem services such as stormwater attenuation, heat amelioration and air purification. The extent to which these benefits are realized is largely dependent on urban forest management objectives, the availability of funding, and the understanding of ecosystem service concepts within local governments, the primary delivery agents of urban forests...
March 21, 2017: Environmental Research
https://www.readbyqxmd.com/read/28342311/lengthy-one-dimensional-magnetite-fe3o4-sub-microfibers-with-excellent-electrochemical-performance
#9
Jianchao Ma, Jiali Chang, Hongzhu Ma, Duoduo Zhang, Qingliang Ma, Shaobin Wang
One dimensional Fe3O4 sub-microfibers with an average diameter of about 920nm and length of about 25μm were prepared by hydrothermal synthesis in the presence of sodium citrate (Na3cit). The physicochemical properties were characterized by X-ray powder diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), and scanning electron microscopy (SEM). It was found that Fe3O4 crystal nuclei were generated from different Fe(2+)-citrate complexes under hydrothermal conditions and Na3cit as a capping agent promoted the formation of Fe3O4 microfibers...
March 18, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28340458/toxic-effects-of-environmental-pollutants-comparative-investigation-using-allium-cepa-l-and-lactuca-sativa-l
#10
Graciele Lurdes Silveira, Maria Gabriela Franco Lima, Gabriela Barreto Dos Reis, Marcel José Palmieri, Larissa Fonseca Andrade-Vieria
Studies that help understand the mechanisms of action of environmental pollutants are extremely important in environmental toxicology. In this context, assays using plants as models stand out for their simplicity and low performance cost. Among the plants used for this purpose, Allium cepa L. is the model most commonly applied for cytogenotoxic tests, while Lactuca sativa L., already widely used in phytotoxic investigations, has been gaining prominence in cytotoxic analyses. The present study aimed to compare the responses of A...
March 21, 2017: Chemosphere
https://www.readbyqxmd.com/read/28340377/possible-protective-effect-of-royal-jelly-against-cyclophosphamide-induced-prostatic-damage-in-male-albino-rats-a-biochemical-histological-and-immuno-histo-chemical-study
#11
Sara Mohammed Naguib Abdel-Hafez, Rehab Ahmed Rifaai, Walaa Yehia Abdelzaher
Almost all the chemotherapy treat many cancer types effectively, but it leads to severe side effects. Chemotherapy like cyclophosphamide (CP) not works only on the active cells, such as cancer cells, but also acts on the healthy cells. Royal jelly (RJ) was reported to have a lot of therapeutic effects besides being an anti-oxidant and anti-cancer agent. The purpose of this study was to assess the possible protective role of RJ in ameliorating the toxic effects of CP overdose in the rat prostatic tissue. The rats were separated into 4 groups; control group, RJ group, CP group and RJ with CP group...
March 21, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28339145/respiratory-syncytial-virus-host-interaction-in-the-pathogenesis-of-bronchiolitis-and-its-impact-on-respiratory-morbidity-in-later-life
#12
REVIEW
Giovanni A Rossi, Andrew A Colin
Rossi GA, Colin AA(.) Respiratory syncytial virus - host interaction in the pathogenesis of bronchiolitis and its impact on respiratory morbidity in later life. Pediatr Allergy Immunol. Respiratory syncytial virus (RSV) is the most common agent of severe airway disease in infants and young children. Large epidemiologic studies have demonstrated a clear relationship between RSV infection and subsequent recurrent wheezing and asthma into childhood, thought to be predominantly related to long-term changes in neuroimmune control of airway tone rather than to allergic sensitization...
March 24, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28339126/boron-doped-polygonal-carbon-nano-onions-synthesis-and-applications-in-electrochemical-energy-storage
#13
Marta Eliza Plonska-Brzezinska, Olena Mykhailiv, Krzysztof Brzezinski, Bogdan Sulikowski, Zbigniew Olejniczak, Malgorzata Gras, Grzegorz Lota, Agustin Molina-Ontoria, Michal Jakubczyk, Luis Echegoyen
Doping of carbon nanostructures with heteroatoms, such as boron or nitrogen, is one of the most effective ways to change their properties to make them suitable for various applications. Carbon nano-onions (CNOs) doped with boron (B-CNOs) have been prepared by annealing (1650°C) nanodiamond particles (NDs) under an inert He atmosphere in the presence of B. Their physicochemical properties were measured using transmission (TEM) and scanning (SEM) electron microscopy, X-ray photoelectron spectroscopy (XPS), 10B and 11B solid-state MAS NMR spectroscopy, X-ray powder diffractions (XRD), Raman spectroscopy, porosimetry, and differential-thermogravimetric analyses (TGA-DTG)...
March 24, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28339096/pathogenesis-and-management-of-antiphospholipid-syndrome
#14
REVIEW
Deepa R J Arachchillage, Mike Laffan
Antiphospholipid antibodies are a heterogeneous group of autoantibodies that have clear associations with thrombosis and pregnancy morbidity, and which together constitute the 'antiphospholipid syndrome' (APS). However, the pathophysiology of these complications is not well understood and their heterogeneity suggests that more than one pathogenic process may be involved. Diagnosis remains a combination of laboratory analysis and clinical observation but there have been significant advances in identifying specific pathogenic features, such as domain I-specific anti-β2-glycoprotein-I antibodies...
March 24, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28339034/the-sirt1-activator-srt1720-attenuates-renal-fibrosis-by-inhibiting-ctgf-and-oxidative-stress
#15
Yunzhuo Ren, Chunyang Du, Yonghong Shi, Jingying Wei, Haijiang Wu, Huixian Cui
The transforming growth factor-β1 (TGF-β1)/connective tissue growth factor (CTGF) pathway plays an important role in the pathogenesis and progression of chronic kidney disease. Oxidative stress is also involved in TGF-β1 signalling. Sirtuin 1 (Sirt1) exerts a number of pleiotropic effects, protecting against renal disease, including inhibiting fibrosis and oxidative metabolism. In this study, we investigated the role of the Sirt1 activator, SRT1720, in unilateral ureteral obstruction (UUO)-induced tubulointerstitial fibrosis and aimed to determine whether this role depends on the inhibition of oxidative stress and the TGF-β1/CTGF pathway...
March 22, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28339024/effects-of-berberine-on-a-rat-model-of-chronic-stress-and-depression-via-gastrointestinal-tract-pathology-and-gastrointestinal-flora-profile-assays
#16
Xiaohui Zhu, Yangdong Sun, Chenggang Zhang, Haifeng Liu
Chronic stress and depression are challenging conditions to treat, owing to their complexity and lack of clinically available and effective therapeutic agents. The aim of the present study was to investigate the mechanism by which berberine acts, by examining alterations to gastrointestinal tract histopathology and flora profile in a rat model, following the induction of stress. Research associating gastrointestinal flora and depression has increased, thus, the present study hypothesized that stress induces depression and changes in the gastrointestinal system...
March 22, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28338672/posttransplant-maintenance-therapy-in-multiple-myeloma-the-changing-landscape
#17
REVIEW
S Sengsayadeth, F Malard, B N Savani, L Garderet, M Mohty
Transplant-eligible patients with multiple myeloma (MM) now have extended survival after diagnosis owing to effective modern treatment strategies that include new agents in induction therapy, autologous stem cell transplant (ASCT), consolidation therapy and posttransplant maintenance therapy. Standard of care for newly diagnosed, fit patients includes ASCT and, often nowadays, posttransplant maintenance. Several large studies have shown the efficacy of maintenance with thalidomide, lenalidomide and bortezomib in the treatment scheme of MM with regards to prolonging progression-free survival and, to a lesser degree, overall survival...
March 24, 2017: Blood Cancer Journal
https://www.readbyqxmd.com/read/28338292/rational-drug-design-of-indazole-based-diarylurea-derivatives-as-anticancer-agents
#18
Yan-Yan Chu, He-Juan Cheng, Zhenhua Tian, Jian-Chun Zhao, Gang Li, Yang-Yang Chu, Chang-Jun Sun, Wen-Bao Li
A series of novel indazole-based diarylurea derivatives targeting c-kit were designed by structure-based drug design. The derivatives were prepared and their antiproliferative activities were evaluated against human colon cancer HCT-116 cell line and hepatocellular carcinoma PLC/PRF/5 cell line. The antiproliferative activities demonstrated that six out of nine compounds exhibited comparable activities with Sorafenib against HCT-116. The structure-activity relationship (SAR) analysis indicated that the indazole ring part tolerated different kinds of substituents, the N position of the central pyridine ring played key roles in antiproliferative activity...
March 24, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28337843/exploring-the-role-of-the-dental-hygienist-in-reducing-oral-health-disparities-in-canada-a-qualitative-study
#19
J Farmer, S Peressini, H P Lawrence
OBJECTIVES: Reducing oral health disparities has been an ongoing challenge in Canada with the largest burden of oral disease exhibited in vulnerable populations, including Aboriginal people, the elderly, rural and remote residents, and newcomers. Dental hygienists are a unique set of professionals who work with and within communities, who have the potential to act as key change agents for improving the oral health of these populations. The purpose of this qualitative study was to explore, from the dental hygiene perspective, the role of dental hygienists in reducing oral health disparities in Canada...
March 24, 2017: International Journal of Dental Hygiene
https://www.readbyqxmd.com/read/28337727/newer-antiepileptic-drugs-in-status-epilepticus-prescription-trends-and-outcomes-in-comparison-with-traditional-agents
#20
Isabelle Beuchat, Jan Novy, Andrea O Rossetti
INTRODUCTION: Newer antiepileptic drugs (AEDs) are increasingly prescribed; however, relatively limited data are available regarding their use in status epilepticus (SE) and the impact on outcome. OBJECTIVES: The aim of this study was to explore the evolution in prescription patterns of newer and traditional AEDs in this clinical setting, and their association with prognosis. METHODS: We analyzed our prospective adult SE registry over a 10-year period (2007-2016) and assessed the yearly use of newer and traditional AEDs and their association with mortality, return to baseline conditions at discharge, and SE refractoriness, defined as treatment resistance to two AEDs, including benzodiazepines...
March 24, 2017: CNS Drugs
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