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https://www.readbyqxmd.com/read/29041000/genetic-variations-of-oxidative-stress-related-genes-alox5-alox5ap-and-mpo-modulate-ischemic-stroke-susceptibility-through-main-effects-and-epistatic-interactions-in-a-chinese-population
#1
Ding Liu, Lei Liu, Zhi Song, Zhongyang Hu, Jia Liu, Deren Hou
BACKGROUND/AIMS: To investigate the roles of the oxidative stress related-genes ALOX5, ALOX5AP and MPO in ischemic stroke susceptibility in the Han Chinese population. METHODS: A total of 351 ischemic stroke patients and 417 controls were recruited. The ALOX5 rs10900213, ALOX5AP rs4293222 and MPO rs2107545 gene polymorphisms were genotyped. RESULTS: We identified that rs2107545 of MPO gene was significantly associated with ischemic stroke susceptibility after adjusting for covariates...
October 17, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29040971/characteristics-and-outcomes-of-vertebrobasilar-artery-dissection-with-accompanied-atherosclerosis
#2
Chun Chien, Feng-Chi Chang, Hui-Chi Huang, Jui-Yao Tsai, Chih-Ping Chung
BACKGROUND: With the popularity of MRI use, vertebrobasilar artery dissection (VBD) has been found more frequently in patients with posterior circulation ischemic stroke (PCS). The relationship between VBD and atherosclerosis is unknown. The present study aimed to prove the hypothesis that PCS with pure VBD (p-VBD) and with VBD and accompanied cervical or cerebral artery atherosclerosis (a-VBD) have distinct manifestations. METHODS: Patients with VBD-related PCS who were prospectively enrolled in the Taipei Veterans General Hospital Stroke Registry between January 1, 2010 and August 31, 2014 were recruited for the present study...
October 17, 2017: Cerebrovascular Diseases Extra
https://www.readbyqxmd.com/read/29040944/inhaled-glucocorticoid-treatment-prevents-the-response-of-cd8-t-cells-in-a-mouse-model-of-allergic-asthma-and-causes-their-depletion-outside-the-respiratory-system
#3
Monika Zuśka-Prot, Tomasz Maślanka
The principal objective of this research has been to determine the safety of inhaled glucocorticoids (GCs) in respect of their effect on CD8(+) T cells within respiratory and extra-respiratory tissues, and to compare it with systemic GC treatment. Another purpose has been to identify whether inhaled and systemic GCs affect the CD8(+) T cell response in the mediastinal lymph nodes (MLNs) and lungs in a mouse model of ovalbumin (OVA)-induced asthma. Ciclesonide and methylprednisolone were used as a model for inhaled and systemic GCs, respectively...
October 14, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29040812/a-randomized-controlled-cross-over-study-of-appetite-related-sensations-after-consuming-snacks-made-from-buckwheat
#4
Danielle M Defries, Jay C Petkau, Terri Gregor, Heather Blewett
With the rising incidence of overweight and obesity in developed countries, there is an interest in developing food products that may aid in satiety and reduce energy intake. Buckwheat is a gluten-free edible seed that has been previously shown to induce changes in post-prandial concentrations of satiety hormones; however, subjective measures of appetite-related sensations and objective measures of energy intake at subsequent meals following buckwheat consumption have not been measured. Thirty eight healthy adults were recruited to participate in a randomized, controlled, cross-over trial with the main objective to determine if consuming snacks made from buckwheat would increase satiety and reduce energy intake compared to snacks comparable in serving size, physical characteristics, and nutrient composition...
October 17, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29040764/rif1-promotes-a-repressive-chromatin-state-to-safeguard-against-endogenous-retrovirus-activation
#5
Pishun Li, Li Wang, Brian D Bennett, Jiajia Wang, Jialun Li, Yufeng Qin, Motoki Takaku, Paul A Wade, Jiemin Wong, Guang Hu
Transposable elements, including endogenous retroviruses (ERVs), constitute a large fraction of the mammalian genome. They are transcriptionally silenced during early development to protect genome integrity and aberrant transcription. However, the mechanisms that control their repression are not fully understood. To systematically study ERV repression, we carried out an RNAi screen in mouse embryonic stem cells (ESCs) and identified a list of novel regulators. Among them, Rif1 displays the strongest effect...
October 11, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29040750/cool-callous-and-in-control-superior-inhibitory-control-in-frequent-players-of-video-games-with-violent-content
#6
Laura Stockdale, Robert G Morrison, Robert Palumbo, James Garbarino, Rebecca L Silton
Research on the effects of media violence exposure has shown robust associations among violent media exposure, increased aggressive behavior, and decreased empathy. Preliminary research indicates that frequent players of violent video games may have differences in emotional and cognitive processes compared to infrequent or non-players, yet research examining the amount and content of game play and the relation of these factors with affective and cognitive outcomes is limited. The present study measured neural correlates of response inhibition in the context of implicit attention to emotion, and how these factors are related to empathic responding in frequent and infrequent players of video games with graphically violent content...
October 4, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/29040743/anger-sensitive-networks-characterising-neural-systems-recruited-during-aggressive-social-interactions-using-data-driven-analysis
#7
Frederike Beyer, Ulrike M Krämer, Christian F Beckmann
Social neuroscience uses increasingly complex paradigms to improve ecological validity, as investigating aggressive interactions with functional magnetic resonance imaging (fMRI; Krämer, Jansma, Tempelmann, & Münte, 2007). Standard analyses for fMRI data typically use general linear models (GLM), which require a priori models of task effects on neural processes. These may inadequately model non-stimulus-locked or temporally overlapping cognitive processes, as mentalizing about other agents.We used the data-driven approach of independent component analysis (ICA) to investigate neural processes involved in a competitive interaction...
October 4, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/29040638/low-serum-progesterone-on-the-day-of-embryo-transfer-is-associated-with-a-diminished-ongoing-pregnancy-rate-in-oocyte-donation-cycles-after-artificial-endometrial-preparation-a-prospective-study
#8
E Labarta, G Mariani, N Holtmann, P Celada, J Remohí, E Bosch
STUDY QUESTION: Is there a relationship between serum progesterone (P) and endometrial volume on the day of embryo transfer (ET) with ongoing pregnancy rate (OPR) in artificial endometrium preparation cycles? SUMMARY ANSWER: Patients with serum P < 9.2 ng/ml on the day of ET had a significantly lower OPR but endometrial volume was not related with OPR. WHAT IS KNOWN ALREADY: A window of optimal serum P levels during the embryo implantation period has been described in artificial endometrium preparation cycles...
October 13, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29040606/pinopode-score-around-the-time-of-implantation-is-predictive-of-successful-implantation-following-frozen-embryo-transfer-in-hormone-replacement-cycles
#9
X Y Jin, L J Zhao, D H Luo, L Liu, Y D Dai, X X Hu, Y Y Wang, X Lin, F Hong, T C Li, S Y Zhang
STUDY QUESTION: Is pinopode measurement of any prognostic value? SUMMARY ANSWER: Pinopode expression was significantly associated with the occurrence of pregnancy after frozen embryo transfer. WHAT IS KNOWN ALREADY: Pinopodes are expressed in the endometrium during the implantation period. Pinopode measurement has been proposed as a marker of endometrial receptivity. STUDY DESIGN, SIZE, DURATION: A prospective cohort study was conducted at the Center of Reproductive Medicine, Sir Run Run Shaw Hospital, between 2014 and 2016, recruiting 172 women with infertility and undergoing frozen embryo transfer following IVF treatment...
October 13, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29040589/corifollitropin-alfa-followed-by-highly-purified-hmg-versus-recombinant-fsh-in-young-poor-ovarian-responders-a-multicentre-randomized-controlled-clinical-trial
#10
Panagiotis Drakopoulos, Thi Ngoc Lan Vuong, Ngoc Anh Vu Ho, Alberto Vaiarelli, Manh Tuong Ho, Christophe Blockeel, Michel Camus, Anh Tuan Lam, Arne van de Vijver, Peter Humaidan, Herman Tournaye, Nikolaos P Polyzos
STUDY QUESTION: Does administration of corifollitropin alfa followed by highly purified (hp) HMG result in higher ongoing pregnancy rates compared with daily recombinant FSH (rFSH) in young poor responders? SUMMARY ANSWER: Corifollitropin alfa followed by hp-HMG does not increase ongoing pregnancy rates compared with rFSH in young poor responders, although more supernumerary cryopreserved embryos were obtained with corifollitropin alfa and hp-HMG. WHAT IS KNOWN ALREADY: Poor ovarian response remains one of the main therapeutic challenges in women undergoing ovarian stimulation, given that very low live birth rates of 6% have been reported in this particular group of infertile patients...
September 23, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29040519/high-gonadotropin-dosage-does-not-affect-euploidy-and-pregnancy-rates-in-ivf-pgs-cycles-with-single-embryo-transfer
#11
Oleksii O Barash, Mary D Hinckley, Evan M Rosenbluth, Kristen A Ivani, Louis N Weckstein
STUDY QUESTION: Does high gonadotropin dosage affect euploidy and pregnancy rates in PGS cycles with single embryo transfer? SUMMARY ANSWER: High gonadotropin dosage does NOT affect euploidy and pregnancy rates in PGS cycles with single embryo transfer. WHAT IS KNOWN ALREADY: PGS has been proven to be the most effective and reliable method for embryo selection in IVF cycles. Euploidy and blastulation rates decrease significantly with advancing maternal age...
October 12, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29040423/title-therapeutic-strategies-utilising-sdf-1%C3%AE-in-ischaemic-cardiomyopathy
#12
Oliver J Ziff, Daniel I Bromage, Derek M Yellon, Sean M Davidson
Heart failure is rapidly increasing in prevalence and will redraw the global landscape for cardiovascular health. Alleviating and repairing cardiac injury associated with myocardial infarction (MI) is key to improving this burden. Homing signals mobilise and recruit stem cells to the ischaemic myocardium where they exert beneficial paracrine effects. The chemoattractant cytokine SDF-1α and its associated receptor CXCR4 are upregulated after MI and appear to be important in this context. Activation of CXCR4 promotes both cardiomyocyte survival and stem cell migration towards the infarcted myocardium...
October 13, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/29040381/the-cug-translated-wt1-not-aug-wt1-is-an-oncogene
#13
Kun Yeong Lee, Young Jin Jeon, Hong Gyum Kim, Joohyun Ryu, Do Young Lim, Sung Keun Jung, Dong Hoon Yu, Hanyong Chen, Ann M Bode, Zigang Dong
The Wilms' tumor 1 (WT1) gene is believed to act as a canonical tumor suppressor. However, it has also been reported to function as an oncogene. Germline WT1 deletion is associated with Wilms' tumor and exogenous WT1 cDNA introduction into cells induces the transcriptional suppression of its oncogenic target genes. In contrast, high WT1 expression is associated with poor prognosis in patients with various cancers. Why WT1 acts as a tumor suppressor under certain conditions, but as an oncogene under other conditions is unknown...
October 10, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/29040326/mycobacterium-tuberculosis-infection-modulates-adipose-tissue-biology
#14
Macarena Beigier-Bompadre, Georgina N Montagna, Anja A Kühl, Laura Lozza, January Weiner, Andreas Kupz, Alexis Vogelzang, Hans-Joachim Mollenkopf, Delia Löwe, Silke Bandermann, Anca Dorhoi, Volker Brinkmann, Kai Matuschewski, Stefan H E Kaufmann
Mycobacterium tuberculosis (Mtb) primarily resides in the lung but can also persist in extrapulmonary sites. Macrophages are considered the prime cellular habitat in all tissues. Here we demonstrate that Mtb resides inside adipocytes of fat tissue where it expresses stress-related genes. Moreover, perigonadal fat of Mtb-infected mice disseminated the infection when transferred to uninfected animals. Adipose tissue harbors leukocytes in addition to adipocytes and other cell types and we observed that Mtb infection induces changes in adipose tissue biology depending on stage of infection...
October 17, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29040323/the-influence-of-alcohol-consumption-on-sickness-presenteeism-and-impaired-daily-activities-the-wirus-screening-study
#15
Randi Wågø Aas, Lise Haveraaen, Hildegunn Sagvaag, Mikkel Magnus Thørrisen
BACKGROUND: Alcohol use is a global health issue and may influence activity performance in a variety of domains, including the occupational and domestic spheres. The aim of the study was to examine the influence of annual drinking frequency and binge drinking (≥6 units at one occasion) on activity impairments both at work (sickness presenteeism) and outside the workplace. METHODS: Employees (n = 3278), recruited from 14 Norwegian private and public companies, responded to a questionnaire containing questions from the Alcohol Use Disorders Identification Test (AUDIT) and the Workplace Productivity and Activity Impairment questionnaire (WPAI)...
2017: PloS One
https://www.readbyqxmd.com/read/29040315/individual-and-environmental-correlates-of-objectively-measured-sedentary-time-in-dutch-and-belgian-adults
#16
Femke van Nassau, Joreintje D Mackenbach, Sofie Compernolle, Ilse de Bourdeaudhuij, Jeroen Lakerveld, Hidde P van der Ploeg
As the detrimental health effects of sedentary behaviour are well established, insight into the individual and environmental factors that influence adults' sedentary behaviour is needed. Most studies to date rely on self-reported measures of sedentary time. Therefore, the aim of the current study was to examine individual and environmental correlates of objectively measured sedentary time in Dutch and Belgian adults. Between March and August 2014, Belgian (n = 133) and Dutch (n = 223) adults, recruited as sub-sample of the SPOTLIGHT survey, wore an ActiGraph accelerometer to provide objectively measured sedentary and moderate to vigorous physical activity time...
2017: PloS One
https://www.readbyqxmd.com/read/29040272/woody-lianas-increase-in-dominance-and-maintain-compositional-integrity-across-an-amazonian-dam-induced-fragmented-landscape
#17
Isabel L Jones, Carlos A Peres, Maíra Benchimol, Lynsey Bunnefeld, Daisy H Dent
Tropical forest fragmentation creates insular biological communities that undergo species loss and changes in community composition over time, due to area- and edge-effects. Woody lianas thrive in degraded and secondary forests, due to their competitive advantage over trees in these habitats. Lianas compete both directly and indirectly with trees, increasing tree mortality and turnover. Despite our growing understanding of liana-tree dynamics, we lack detailed knowledge of the assemblage-level responses of lianas themselves to fragmentation, particularly in evergreen tropical forests...
2017: PloS One
https://www.readbyqxmd.com/read/29040222/neurovascular-response-during-exercise-and-mental-stress-in-anabolic-steroid-users
#18
Rafael Armani Porello, Marcelo Rodrigues Dos Santos, Francis Ribeiro de Souza, Guilherme Wesley Peixoto da Fonseca, Ana Luiza Carrari Sayegh, Tiago Franco de Oliveira, César Abreu Akiho, Maurício Yonamine, Rosa Maria Rodrigues Pereira, Carlos Eduardo Negrão, Maria-Janieire de Nazaré Nunes Alves
PURPOSE: Increased resting muscle sympathetic nerve activity (MSNA) and lower forearm blood flow (FBF) were observed in young men who use anabolic androgenic steroids (AAS). However, the response of MSNA and FBF in AAS users triggered by muscle mechanoreflex and central command has never been tested. Additionally, we evaluated the blood pressure (BP) and heart rate (HR) responses during these maneuvers. METHODS: Nineteen AAS users (AASU) aged 31±6 yr and 18 AAS nonusers (AASNU) aged 29±4 yr were recruited...
October 16, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29040211/altered-macular-microvasculature-in-mild-cognitive-impairment-and-alzheimer-disease
#19
Hong Jiang, Yantao Wei, Yingying Shi, Clinton B Wright, Xiaoyan Sun, Giovanni Gregori, Fang Zheng, Elizabeth A Vanner, Byron L Lam, Tatjana Rundek, Jianhua Wang
BACKGROUND: The goal of the present study was to analyze the macular microvacular network in mild cognitive impirment (MCI) and Alzheimer disease (AD). METHODS: Twelve patients with AD and 19 patients with MCI were recruited together with 21 cognitively normal controls with a similar range of ages. Optical coherence tomography angiography was used to image the retinal microvascular network at the macular region, including retinal vascular network (RVN), superficial vascular plexus (SVP), and deep vascular plexus (DVP)...
October 16, 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/29040208/an-update-on-gain-of-function-mutations-in-primary-immunodeficiency-diseases
#20
Rekha D Jhamnani, Sergio D Rosenzweig
PURPOSE OF REVIEW: Most primary immunodeficiencies described since 1952 were associated with loss-of-function defects. With the advent and popularization of unbiased next-generation sequencing diagnostic approaches followed by functional validation techniques, many gain-of-function mutations leading to immunodeficiency have also been identified. This review highlights the updates on pathophysiology mechanisms and new therapeutic approaches involving primary immunodeficiencies because of gain-of-function mutations...
October 16, 2017: Current Opinion in Allergy and Clinical Immunology
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