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https://www.readbyqxmd.com/read/28202030/upregulation-of-interleukin-33-and-thymic-stromal-lymphopoietin-levels-in-the-lungs-of-idiopathic-pulmonary-fibrosis
#1
Jong-Uk Lee, Hun Soo Chang, Hyeon Ju Lee, Chang An Jung, Da Jeong Bae, Hyun Ji Song, Jong Sook Park, Soo-Taek Uh, Young Hoon Kim, Ki-Hyun Seo, Choon-Sik Park
BACKGROUND: Innate T helper type 2 (Th2) immune responses mediated by interleukin (IL)-33, thymic stromal lymphopoietin (TSLP), and IL-25 have been shown to play an important role in pulmonary fibrosis of animal models; however, their clinical implications remain poorly understood. METHODS: TSLP, IL-25, and IL-33 concentrations were measured in bronchoalveolar lavage fluids obtained from normal controls (NCs; n = 40) and from patients with idiopathic pulmonary fibrosis (IPF; n = 100), non-specific interstitial pneumonia (NSIP; n = 22), hypersensitivity pneumonitis (HP; n = 20), and sarcoidosis (n = 19)...
February 15, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28199345/impact-of-chronic-rhinosinusitis-on-severe-asthma-patients
#2
Ta-Jen Lee, Chia-Hsiang Fu, Chun-Hua Wang, Chi-Che Huang, Chien-Chia Huang, Po-Hung Chang, Yi-Wei Chen, Chia-Chen Wu, Ching-Lung Wu, Han-Pin Kuo
Coexistence of chronic rhinosinusitis (CRS) with asthma appears to impair asthma control. Type-2 innate lymphoid cells (ILC2s) respond to the cytokines of thymic stromal lymphopoietin (TSLP), interleukin (IL)-25 and IL-33, thus contributing to airway diseases such as CRS and asthma. We investigate whether the augmented Th2-cytokines in CRS might be related to sinonasal tract ILC2s corresponding to enhanced IL-25, IL-33 and TSLP release in severe asthmatics, and be involved in asthma control. Twenty-eight asthmatics (12 non-severe and 16 severe) with CRS receiving nasal surgery were enrolled...
2017: PloS One
https://www.readbyqxmd.com/read/28182643/ige-sensitization-to-inhalant-allergens-and-the-risk-of-airway-infection-and-disease-a-population-based-study
#3
Tea Skaaby, Lise Lotte Nystrup Husemoen, Betina Heinsbæk Thuesen, Runa Vavia Fenger, Allan Linneberg
BACKGROUND: Immunoglobulin E (IgE) sensitization, which is the propensity to develop IgE antibodies against common environmental allergens, is associated with a lymphocyte T-helper type 2 (Th2) skewed immune response and a high risk of allergic respiratory disease. Little is known about whether IgE sensitization confers an increased risk of respiratory infections in adults. We investigated the association between IgE sensitization and the incidence of acute airway infections, other infections and chronic lower airway disease events as recorded in nation-wide registries...
2017: PloS One
https://www.readbyqxmd.com/read/28179442/t-helper-cell-type-2-th2-and-non-th2-molecular-phenotypes-of-asthma-using-sputum-transcriptomics-in-u-biopred
#4
Chih-Hsi Scott Kuo, Stelios Pavlidis, Matthew Loza, Fred Baribaud, Anthony Rowe, Iaonnis Pandis, Ana Sousa, Julie Corfield, Ratko Djukanovic, Rene Lutter, Peter J Sterk, Charles Auffray, Yike Guo, Ian M Adcock, Kian Fan Chung
Asthma is characterised by heterogeneous clinical phenotypes. Our objective was to determine molecular phenotypes of asthma by analysing sputum cell transcriptomics from 104 moderate-to-severe asthmatic subjects and 16 nonasthmatic subjects.After filtering on the differentially expressed genes between eosinophil- and noneosinophil-associated sputum inflammation, we used unbiased hierarchical clustering on 508 differentially expressed genes and gene set variation analysis of specific gene sets.We defined three transcriptome-associated clusters (TACs): TAC1 (characterised by immune receptors IL33R, CCR3 and TSLPR), TAC2 (characterised by interferon-, tumour necrosis factor-α- and inflammasome-associated genes) and TAC3 (characterised by genes of metabolic pathways, ubiquitination and mitochondrial function)...
February 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28176427/uterine-serpin-serpina-14-correlates-negatively-with-cytokine-production-at-the-foetal-maternal-interface-but-not-in-the-corpus-luteum-in-pregnant-dairy-heifers-experimentally-infected-with-neospora-caninum
#5
B Serrano-Pérez, S Almería, R Mur-Novales, I López-Helguera, I Garcia-Ispierto, J L Alabart, L Darwich, F López-Gatius
This study examines gene expression patterns in dairy heifers experimentally infected with N. caninum during on Day 110 of pregnancy with live foetuses at euthanasia, 42 days later. The study population was constituted of four non-infected controls and three infected dams. Gene expression was determined on gamma interferon (IFNγ), (Th1 pro-inflammatory cytokine), interleukin-4 (IL4) (Th2 pro-gestation cytokine) or interleukin-10 (IL10) (T regulatory cytokine) and the serine peptidase inhibitor SERPINA14 in intercaruncular, placental, uterine lymph node (UTLN) and luteal tissue samples...
February 7, 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/28148790/immunization-with-low-doses-of-recombinant-post-fusion-or-pre-fusion-rsv-f-primes-for-vaccine-enhanced-disease-in-the-cotton-rat-model-independent-of-the-presence-of-a-th1-biasing-gla-se-or-th2-biasing-alum-adjuvant
#6
Kirsten Schneider-Ohrum, Corinne Cayatte, Angie Snell Bennett, Gaurav Manohar Rajani, Patrick McTamney, Krystal Nacel, Leigh Hostetler, Lily Cheng, Kuishu Ren, Terrence O'Day, Gregory A Prince, Michael P McCarthy
: Respiratory syncytial virus (RSV) infection of children previously immunized with a non-live, formalin-inactivated (FI)-RSV vaccine was associated with serious enhanced respiratory disease (ERD). Consequently, detailed studies of potential ERD are a critical step in the development of non-live RSV vaccines targeting RSV-naïve children and infants. The fusion glycoprotein (F) of RSV in either its post- or pre-fusion conformation is a target for neutralizing antibodies and therefore an attractive antigen candidate for a pediatric RSV subunit vaccine...
February 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28137499/association-of-interleukin-25-levels-with-development-of-aspirin-induced-respiratory-diseases
#7
Jong-Uk Lee, Hun Soo Chang, Hyeon Ju Lee, Da-Jeong Bae, Ji-Hye Son, Jong-Sook Park, Jae Sung Choi, Hun Gyu Hwang, Choon-Sik Park
BACKGROUND: Aspirin-exacerbated respiratory diseases (AERD) are caused by ingestion of non-steroidal anti-inflammatory drugs and are characterized by acute bronchospasms and marked infiltration of eosinophils, the latter being attributable to altered synthesis of cysteinyl leukotrienes (LT) and prostaglandins (PG). Recently, the innate Th2 response is revealed to induce eosinophil infiltration in allergic inflammation, however the role of the innate Th2 response has not been studies in AERD...
February 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28129666/non-invasive-proteome-analysis-of-psoriatic-stratum-corneum-reflects-pathophysiological-pathways-and-is-useful-for-drug-profiling
#8
B Méhul, G Laffet, A Séraïdaris, L Russo, P Fogel, I Carlavan, C Pernin, P Andres, C Queille-Roussel, J J Voegel
BACKGROUND: Protein expression is disturbed in psoriatic stratum corneum. Non-invasive methods for the description of pathophysiological changes and drug profiling in psoriasis are desirable. OBJECTIVES: Undertake large scale non-invasive protein expression studies in psoriatic stratum corneum to identify biomarkers of pathophysiological processes and use them for drug profiling. METHODS: Psoriatic stratum corneum was harvested through repetitive tape-stripping...
January 27, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28126014/attachment-of-class-b-cpg-odn-onto-dotap-dc-chol-liposome-in-nasal-vaccine-formulations-augments-antigen-specific-immune-responses-in-mice
#9
Rui Tada, Shoko Muto, Tomoko Iwata, Akira Hidaka, Hiroshi Kiyono, Jun Kunisawa, Yukihiko Aramaki
BACKGROUND: To overcome infectious diseases, the development of mucosal vaccines would be an effective strategy, since mucosal surfaces are the entry site for most pathogens. In general, protein antigens show inherently poor immunogenicity when administered by the mucosal route. Therefore, co-administration of an appropriate mucosal adjuvant is required to exert immune responses toward pathogen-derived antigens effectively. However, the development of a safe and effective mucosal adjuvant system is still challenging...
January 26, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28125562/o-014-bacterial-sensor-nod2-deletion-causes-th2-inflammatory-bowel-disease-improvement-without-inducing-acute-metatranscriptomic-dysbiosis-in-mice
#10
Alexander Rodriguez-Palacios, Daniele Corridoni, Gabriella Di Stefano, Luca Di Martino, D A Antonopoulos, Eugene Chang, T T Pizarro, Fabio Cominelli
BACKGROUND: Although single nucleotide polymorphisms in the NOD2 (nucleotide-binding oligomerization domain-containing 2) gene have been associated with the pathogenesis of Crohn's disease (CD), little is known about the role of nonpolymorphic wild-type (WT) NOD2 genes in the gut. To date, most animal studies addressing the role of WT NOD2 have been conducted using healthy (ileitis/colitis-free) mouse strains, and have attributed a modulating effect to the gut microbiome, partly based on 16S rRNA sequencing...
February 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28124467/species-specific-immunity-to-helicobacter-suis
#11
Iris Bosschem, Bram Flahou, Kim Van Deun, Stefaan De Koker, Jiri Volf, Annemieke Smet, Richard Ducatelle, Bert Devriendt, Freddy Haesebrouck
BACKGROUND: Helicobacter (H.) suis is mainly associated with pigs, but is also the most prevalent gastric non-H. pylori Helicobacter species found in humans. Both H. pylori and H. suis may cause persistent infection of the stomach. Several immune evasion mechanisms have been proposed for H. pylori, which focus to a great extent on its major virulence factors, which are absent in H. suis. The aim of this study was to gain more knowledge on immune evasion by H. suis. MATERIALS AND METHODS: Cytokine expression kinetics were monitored in the stomach of BALB/c mice experimentally infected with H...
January 26, 2017: Helicobacter
https://www.readbyqxmd.com/read/28114408/functional-haplotypes-in-interleukin-4-gene-associated-with-periodontitis
#12
Giovana Anovazzi, Marcell Costa de Medeiros, Suzane Cristina Pigossi, Livia Sertori Finoti, Marcia Pinto Alves Mayer, Carlos Rossa, Raquel Mantuaneli Scarel-Caminaga
Chronic periodontitis (CP) is an infectious inflammatory disease that affects tooth-supporting structures and in which dental plaque bacteria, immune mechanisms and genetic predisposition play important roles. Interleukin 4 (IL-4) is a key anti-inflammatory cytokine with relevant action in imbalances in inflamed periodontal tissue. Individuals carrying the TCI/CCI genotype (S-haplotype) of the IL-4 gene are 5 times more susceptible to CP, whereas the CTI/TTD genotype (P-haplotype) confers protection against CP...
2017: PloS One
https://www.readbyqxmd.com/read/28114290/the-transcription-factor-musculin-promotes-the-unidirectional-development-of-peripheral-treg-cells-by-suppressing-the-th2-transcriptional-program
#13
Chuan Wu, Zuojia Chen, Valerie Dardalhon, Sheng Xiao, Theresa Thalhamer, Mengyang Liao, Asaf Madi, Rafael F Franca, Timothy Han, Mohammed Oukka, Vijay Kuchroo
Although master transcription factors (TFs) are key to the development of specific T cell subsets, whether additional transcriptional regulators are induced by the same stimuli that dominantly repress the development of other, non-specific T cell lineages has not been fully elucidated. Through the use of regulatory T cells (Treg cells) induced by transforming growth factor-β (TGF-β), we identified the TF musculin (MSC) as being critical for the development of induced Treg cells (iTreg cells) by repression of the T helper type 2 (TH2) transcriptional program...
January 23, 2017: Nature Immunology
https://www.readbyqxmd.com/read/28112425/in-situ-immunopathological-changes-in-cutaneous-leishmaniasis-due-to-leishmania-donovani
#14
Nuwani H Manamperi, Steve Oghumu, Nishantha Pathirana, Vipula C de Silva, Wimaladharma Abeyewickreme, Abhay R Satoskar, Nadira D Karunaweera
INTRODUCTION: Cutaneous leishmaniasis in Sri Lanka is a newly established parasitic disease caused by the usually visceralizing Leishmania donovani. Skin lesions manifest as non-itchy, non-tender papules, nodules or ulcers. In situ cytokine expression provides clues for immunopathogenesis of this localized form of disease. METHODS: Skin biopsies from 58 patients were analyzed for histological appearance and in situ cytokine expression of T- helper 1 (Th1) and T- helper 2 (Th2) cytokines, namely interferon (IFN)-γ, interleukin (IL)-12A, tumor necrosis factor (TNF)-α, IL-4 and IL-10 by real-time RT- PCR...
January 23, 2017: Parasite Immunology
https://www.readbyqxmd.com/read/28106273/the-immunoglobulin-superfamily-member-cd200r-identifies-cells-involved-in-type-2-immune-responses
#15
Lars H Blom, Britta C Martel, Lau F Larsen, Camilla V Hansen, Malene P Christensen, Nanna Juel-Berg, Thomas Litman, Lars K Poulsen
BACKGROUND: The pathology of allergic diseases involves type 2 immune cells, such as Th2, ILC2, and basophils exerting their effect by production of IL-4, IL-5, and IL-13. However, surface receptors that are specifically expressed on type 2 immune cells are less well documented. The aim of this investigation was to identify surface markers associated with type 2 inflammation. METHODS: Naïve human CD4(+) T-cells were short-term activated in the presence or absence of IL-4, and analysed for expression of >300 cell-surface proteins...
January 20, 2017: Allergy
https://www.readbyqxmd.com/read/28103916/tim-1-defines-a-human-regulatory-b-cell-population-that-is-altered-in-frequency-and-function-in-systemic-sclerosis-patients
#16
Octavio Aravena, Ashley Ferrier, Madhvi Menon, Claudia Mauri, Juan Carlos Aguillón, Lilian Soto, Diego Catalán
BACKGROUND: Systemic sclerosis (SSc) is a systemic autoimmune disease characterized by excessive production of extracellular matrix by fibroblasts on skin and internal organs. Although Th2 cells have been involved in fibroblast stimulation, hyperactivated B cells may also play an important role. Regulatory B cells (Bregs) are cells capable of inhibiting inflammatory responses and controlling autoimmune diseases. Although many Breg populations have in common the ability to produce high amounts of IL-10, a unique surface marker defining most human Bregs is lacking...
January 19, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28103528/topical-vaccination-with-super-stable-ready-to-use-nanovesicles
#17
Ayelen Tatiana Caimi, Federico Parra, Marcelo Alexandre de Farias, Rodrigo Villares Portugal, Ana Paula Perez, Eder Lilia Romero, Maria Jose Morilla
Ultradeformable archaeosomes (UDA) are nanovesicles made of total polar archaeolipids (TPA) from the archaea Halorubrum tebenquichense, soybean phosphatidylcholine and sodium cholate (3:3:1w/w). Fresh dispersions of UDA including different type of antigens are acknowledged as efficient topical vaccination agents. UDA dispersions however, if manufactured for pharmaceutical use, have to maintain colloidal stability upon liposomicidal processes such as sterilization and lyophilization (SLRUDA), needed to extend shelf life during storage...
December 26, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28101024/bazex-syndrome-in-lung-squamous-cell-carcinoma-high-expression-of-epidermal-growth-factor-receptor-in-lesional-keratinocytes-with-th2-immune-shift
#18
Maki Amano, Takaaki Hanafusa, Sakiko Chikazawa, Makiko Ueno, Takeshi Namiki, Ken Igawa, Keiko Miura, Hiroo Yokozeki
An 82-year-old Japanese man was referred for detailed examination of hyperkeratotic erythematous plaques on his palms and soles for 6 months. Two weeks before his first visit, he had undergone lung lobectomy for right lung squamous cell carcinoma (SCC). Laboratory findings showed elevations of eosinophil counts, serum IgE, thymus and activation-regulated chemokine, SCC antigen, and soluble interleukin-2 receptor levels. Histological results of a skin biopsy involving the left palm showed psoriasiform dermatitis...
September 2016: Case Reports in Dermatology
https://www.readbyqxmd.com/read/28089609/de-immunized-and-functional-therapeutic-deft-versions-of-a-long-lasting-recombinant-alpha-interferon-for-antiviral-therapy
#19
Eduardo F Mufarrege, Sofía Giorgetti, Marina Etcheverrigaray, Frances Terry, William Martin, Anne S De Groot
Interferon α (IFN-α) exerts potent antiviral, immunomodulatory, and antiproliferative activity and have proven clinical utility in chronic hepatitis B and C virus infections. However, repeated IFN-α administration induces neutralizing antibodies (NAb) against the therapeutic in a significant number of patients. Associations between IFN-α immunogenicity and loss of efficacy have been described. So as to improve the in vivo biological efficacy of IFN-α, a long lasting hyperglycosylated protein (4N-IFN) derived from IFN-α2b wild type (WT-IFN) was developed...
January 10, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28061450/th1high-in-tumor-microenvironment-is-an-indicator-of-poor-prognosis-for-patients-with-nsclc
#20
Huang Jian, Shen Fangrong, Huang Haitao, Ling Chunhua, Zhang Guangbo
CD4+Th subsets play an important role in tumor progression but their expression characteristics and clinical significance in human tumor microenvironment remains unclear. In this study, we aim to analyze the expression and clinical significance of tissue-infiltrating Th1, Th2 and Th17 in lung cancer by flow cytometry. We found that the frequency of CD3+CD4+IFN-γ+Th1 in tumor nest was significantly lower than that in tumor boundary, adjacent normal lung tissue or corresponding lymph node tissue; the frequency of CD3+CD4+IL-4+Th2 in tumor nest was significantly higher than that in tumor boundary, adjacent normal lung tissue or corresponding lymph node tissue; the frequency of CD3+CD4+IL-17+Th17 in tumor nest was significantly lower than that in tumor boundary, but not adjacent normal tissue or corresponding lymph node tissue...
January 3, 2017: Oncotarget
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