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https://www.readbyqxmd.com/read/28921585/allergooncology-opposite-outcomes-of-immune-tolerance-in-allergy-and-cancer
#1
E Jensen-Jarolim, H J Bax, R Bianchini, S Crescioli, T R Daniels-Wells, D Dombrowicz, E Fiebiger, H J Gould, S Irshad, J Janda, D H Josephs, F Levi-Schaffer, L O Mahony, G Pellizzari, M L Penichet, F Redegeld, F Roth-Walter, J Singer, E Untersmayr, L Vangelista, S N Karagiannis
While desired for the cure of allergy, regulatory immune cell subsets and non-classical Th2-biased inflammatory mediators in the tumour microenvironment can contribute to immune suppression and escape of tumours from immunological detection and clearance. A key aim in the cancer field is therefore to design interventions that can break immunological tolerance and halt cancer progression, whereas on the contrary allergen immunotherapy exactly aims to induce tolerance. In this position paper, we review insights on immune tolerance derived from allergy and from cancer inflammation, focusing on what is known about the roles of key immune cells and mediators...
September 16, 2017: Allergy
https://www.readbyqxmd.com/read/28912627/il-25-could-be-involved-in-the-development-of-allergic-rhinitis-sensitized-to-house-dust-mite
#2
Dae Woo Kim, Dong-Kyu Kim, Kyoung Mi Eun, Jun-Sang Bae, Young-Jun Chung, Jun Xu, Yong Min Kim, Ji-Hun Mo
BACKGROUND AND PURPOSE: When house dust mite (HDM), a common allergen, comes into the mucosal membrane, it may stimulate innate immunity. However, the precise role of interleukin- (IL-) 25 in the development of HDM-induced nasal allergic inflammation is still unclear. Therefore, we investigated the role of IL-25 in allergic rhinitis (AR) patients sensitized to HDM. METHODS: To confirm the production of IL-25 in human nasal epithelial cells (HNECs), we stimulated HNECs...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28912020/intestinal-dysbiosis-featuring-abundance-of-ruminococcus-gnavus-associates-with-allergic-diseases-in-infants
#3
Huey-Huey Chua, Hung-Chieh Chou, Ya-Ling Tung, Bor-Luen Chiang, Chien-Chia Liao, Hong-Hsing Liu, Yen-Hsuan Ni
BACKGROUND & AIMS: Dysbiosis of the intestinal microbiota has been associated with development of allergies in infants. However, it is not clear what microbes might contribute to this process. We investigated what microbe(s) might be involved in analyses of infant twins and mice. METHODS: We studied fecal specimens prospectively in a twin cohort (n=30) and age-matched singletons (n=14) born at National Taiwan University Children's Hospital, Taipei, Taiwan, from April 2011 to March 2013...
September 11, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28892752/graphene-quantum-dots-suppress-proinflammatory-t-cell-responses-via-autophagy-dependent-induction-of-tolerogenic-dendritic-cells
#4
Sergej Tomić, Kristina Janjetović, Dušan Mihajlović, Marina Milenković, Tamara Kravić-Stevović, Zoran Marković, Biljana Todorović-Marković, Zdenko Spitalsky, Matej Micusik, Dragana Vučević, Miodrag Čolić, Vladimir Trajković
Graphene quantum dots (GQD) are atom-thick nanodimensional carbon sheets with excellent physico-chemical and biological properties, making them attractive for application in theranostics. However, their immunoregulatory properties are insufficiently investigated, especially in human primary immune cells. We found that non-toxic doses of GQD inhibit the production of proinflammatory and T helper (Th)1 cytokines, and augment the production of anti-inflammatory and Th2 cytokines by human peripheral blood mononuclear cells...
August 29, 2017: Biomaterials
https://www.readbyqxmd.com/read/28892576/pregnancy-modulates-the-allergen-induced-cytokine-production-differently-in-allergic-and-non-allergic-women
#5
Martina Sandberg Abelius, Malin Jedenfalk, Jan Ernerudh, Camilla Janefjord, Göran Berg, Leif Matthiesen, Maria C Jenmalm
BACKGROUND: The immunological environment during pregnancy may differ between allergic and non-allergic women. This study investigates the effect of maternal allergy on the allergen-induced cytokine and chemokine levels and if pregnancy modulates these immune responses differently in allergic and non-allergic women. METHODS: The birch-, cat-, phytohemagglutinin- and tetanus toxoid-induced interferon-γ (IFN-γ), interleukin-4 (IL)-4, IL-5, IL-10, IL-13, the T-helper 1 (Th1)-associated chemokine CXCL10 and the Th2-associated chemokine CCL17 levels were quantified in 20 women with allergic symptoms (sensitised, n=13) and 36 women without allergic symptoms (non-sensitised, n=30) at gestational weeks 10-12, 15-16, 25, 35 and 2 and 12 months postpartum...
September 11, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28875310/simultaneous-analysis-of-multiple-t-helper-subsets-in-leprosy-reveals-distinct-patterns-of-th1-th2-th17-and-tregs-markers-expression-in-clinical-forms-and-reactional-events
#6
Michelle de Campos Soriani Azevedo, Heloisa Marques, Larissa Sarri Binelli, Mariana Silva Vieira Malange, Amanda Carreira Devides, Eliane Aparecida Silva, Luciana Raquel Vincenzi Fachin, Cassio Cesar Ghidella, Cleverson Teixeira Soares, Gustavo Pompermaier Garlet, Patrícia Sammarco Rosa, Andrea de Farias Fernandes Belone, Ana Paula Favaro Trombone
Leprosy is a chronic infectious disease caused by Mycobacterium leprae. Previous studies have demonstrated that the difference among clinical forms of leprosy can be associated with the immune response of patients, mainly by T helper (Th) and regulatory T cells (Tregs). Then, aiming at clarifying the immune response, the expression of cytokines related to Th1, Th2, Th17 and Tregs profiles were evaluated by qPCR in 87 skin biopsies from leprosy patients. Additionally, cytokines and anti-PGL-1 antibodies were determined in serum by ELISA...
September 5, 2017: Medical Microbiology and Immunology
https://www.readbyqxmd.com/read/28863927/the-role-of-non-invasive-modalities-for-assessing-inflammation-in-patients-with-non-cystic-fibrosis-bronchiectasis
#7
Stamatoula Tsikrika, Katerina Dimakou, Andriana I Papaioannou, Georgios Hillas, Loukas Thanos, Kostantinos Kostikas, Stelios Loukides, Spyros Papiris, Nickolaos Koulouris, Petros Bakakos
INTRODUCTION: Bronchiectasis is a heterogeneous entity, taking into account clinical characteristics, inflammatory response, effectiveness of treatment and frequency of exacerbations. In stable state non-cystic fibrosis (non-CF) bronchiectasis, little is known about non-invasive techniques used for evaluating airway inflammation in obstructive airway diseases. OBJECTIVES: We sought to evaluate the associations between induced sputum and clinical/radiologic characteristics, and the differences between biomarkers expressing Th1 and Th2 response in patients with non-CF bronchiectasis and to compare our findings with a previously studied population of patients with asthma and COPD...
August 29, 2017: Cytokine
https://www.readbyqxmd.com/read/28857184/pathogenicity-of-memory-th2-cells-is-linked-to-stage-of-allergic-rhinitis
#8
T Iinuma, Y Okamoto, Y Morimoto, T Arai, T Sakurai, S Yonekura, D Sakurai, K Hirahara, T Nakayama
BACKGROUND: Allergic rhinitis (AR) consists of three developmental stages that are based on the presence/absence of antigen-specific IgE and symptoms. The pathogenic Th2 (Tpath2) cells constitute a population of Th2 cells with additional potentially pathogenic characteristics. We examined the relationship between Tpath2 cells and the stages of allergic rhinitis by focusing on ST2, which is an IL-33 receptor. METHODS: Patients with Japanese cedar pollen-induced AR (JCP-AR) and healthy volunteers were divided into "nonsensitized," "asymptomatic sensitized (AS)," and "JCP-AR" groups...
August 30, 2017: Allergy
https://www.readbyqxmd.com/read/28828575/improving-the-efficacy-of-a-prophylactic-vaccine-formulation-against-lymphatic-filariasis
#9
Nikhil Chauhan, Priyankana Banerjee, Vishal K Khatri, Andrew Canciamille, Jessica Gilles, Ramaswamy Kalyanasundaram
Mass drug administration (MDA) is the current strategy for interrupting the transmission of lymphatic filariasis (LF) infection and control of the disease in endemic areas. However, subject non-compliance has resulted in the presence of several "transmission hotspots" in the endemic regions threatening the reemergence of LF. This situation is further complicated by the fact that the drugs used in MDA are not effective against adult LF worms, a major concern for the control strategy. Thus, there is clearly a need for an effective and sustainable approach to control LF...
August 21, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28826655/subtyping-of-type-1-diabetes-as-classified-by-anti-gad-antibody-ige-levels-and-tyrosine-kinase-2-tyk2-promoter-variant-in-the-japanese
#10
Keiichiro Mine, Kanako Hirakawa, Shiori Kondo, Masae Minami, Akira Okada, Nobutaka Tsutsu, Yasushi Yokogawa, Yumi Hibio, Fumiko Kojima, Shuji Fujimoto, Hironori Kurisaki, Keizo Anzai, Yasunobu Yoshikai, Seiho Nagafuchi
OBJECTIVE: Type 1 diabetes (T1D) is known to be caused by Th1 cell-dependent autoimmunity. Recently, we reported that TYK2 promoter variant serves as a putative virus-induced diabetes susceptibility gene associated with deteriorated interferon-dependent antiviral response. TYK2 is also related to HIES, that is, Th2 cell-dependent. Therefore, TYK2 promoter variant may be also associated with the pathogenesis of T1D, modulating Th1/Th2 balance. RESEARCH DESIGN AND METHODS: We assessed the association between anti- GAD Ab, IgE levels, and TYK2 promoter variant among 313 T1D patients, 184 T2D patients, and 264 YH controls in the Japanese...
August 12, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28821884/the-atopic-dermatitis-blood-signature-is-characterized-by-increases-in-inflammatory-and-cardiovascular-risk-proteins
#11
Patrick M Brunner, Mayte Suárez-Fariñas, Helen He, Kunal Malik, Huei-Chi Wen, Juana Gonzalez, Tom Chih-Chieh Chan, Yeriel Estrada, Xiuzhong Zheng, Saakshi Khattri, Nancy Dattola, James G Krueger, Emma Guttman-Yassky
Beyond classic "allergic"/atopic comorbidities, atopic dermatitis (AD) emerges as systemic disease with increased cardiovascular risk. To better define serum inflammatory and cardiovascular risk proteins, we used an OLINK high-throughput proteomic assay to analyze moderate-to-severe AD (n = 59) compared to psoriasis (n = 22) and healthy controls (n = 18). Compared to controls, 10 proteins were increased in serum of both diseases, including Th1 (IFN-γ, CXCL9, TNF-β) and Th17 (CCL20) markers. 48 proteins each were uniquely upregulated in AD and psoriasis...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28802664/cytokines-and-soluble-hla-g-levels-in-bone-marrow-stroma-and-their-association-with-the-survival-rate-of-patients-exhibiting-childhood-t-cell-acute-lymphoblastic-leukemia
#12
Renata Dos Santos Almeida, Alessandra Maria de Luna Ramos, Carlos Feitosa Luna, Francisco Pedrosa, Eduardo Antônio Donadi, Norma Lucena-Silva
Leukemic cells can induce defective expression of soluble factors and change marrow cytokine profile, leading to aberrant cell signaling, cell fixation and cell proliferation in bone marrow. T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive disorder which accounts for 15% of pediatric ALL. To evaluate the contribution of immunological factors on T-ALL survival, we measured Th1, Th2, Th17 cytokines and soluble HLA-G (sHLA-G) levels in bone marrow from 32 Brazilian children at diagnosis (D0), after induction (D19) and after consolidation (D49) of the chemotherapy phase...
August 9, 2017: Cytokine
https://www.readbyqxmd.com/read/28789852/recombinant-calponin-of-human-filariid-brugia-malayi-secondary-structure-and-immunoprophylactic-potential
#13
Shiv K Verma, Ashish Arora, P Kalpana Murthy
In the search for potential vaccine candidates for the control of human lymphatic filariasis, we recently identified calponin-like protein, that regulates actin/myosin interactions, in a proinflammatory fraction F8 (45.24-48.64kDa) of Brugia malayi adult worms. In the present study, the gene was cloned, expressed, and the recombinant Calponin of B. malayi (r-ClpBm) was prepared and characterized. r-ClpBm bears homology with OV9M of Onchocerca volvulus, a non-lymphatic filariid that causes loss of vision and cutaneous pathology...
August 5, 2017: Vaccine
https://www.readbyqxmd.com/read/28783679/a-tslp-complement-axis-mediates-neutrophil-killing-of-methicillin-resistant-staphylococcus-aureus
#14
Erin E West, Rosanne Spolski, Majid Kazemian, Zu Xi Yu, Claudia Kemper, Warren J Leonard
Community-acquired Staphylococcus aureus infections often present as serious skin infections in otherwise healthy individuals and have become a worldwide epidemic problem fueled by the emergence of strains with antibiotic resistance, such as methicillin-resistant S. aureus (MRSA). The cytokine thymic stromal lymphopoietin (TSLP) is highly expressed in the skin and in other barrier surfaces and plays a deleterious role by promoting T helper cell type 2 (TH2) responses during allergic diseases; however, its role in host defense against bacterial infections has not been well elucidated...
November 18, 2016: Science Immunology
https://www.readbyqxmd.com/read/28770200/prostaglandins-and-their-receptors-in-eosinophil-function-and-as-therapeutic-targets
#15
REVIEW
Miriam Peinhaupt, Eva M Sturm, Akos Heinemann
Of the known prostanoid receptors, human eosinophils express the prostaglandin D2 (PGD2) receptors DP1 [also D-type prostanoid (DP)] and DP2 (also chemoattractant receptor homologous molecule, expressed on Th2 cells), the prostaglandin E2 receptors EP2 and EP4, and the prostacyclin (PGI2) receptor IP. Prostanoids can bind to either one or multiple receptors, characteristically have a short half-life in vivo, and are quickly degraded into metabolites with altered affinity and specificity for a given receptor subtype...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28767393/immunological-cytokine-profiling-identifies-tnf-%C3%AE-as-a-key-molecule-dysregulated-in-autistic-children
#16
Jiang Xie, Li Huang, Xiaohong Li, Hua Li, Yongmei Zhou, Hua Zhu, Tianying Pan, Keith M Kendrick, Wenming Xu
Recent studies have suggested that the etiology of Autism Spectrum Disorder (ASD) may be caused by immunological factors, particularly abnormalities in the innate immune system. However, it is still unclear which specific cytokines may be of most importance. The current study therefore investigated which cytokines showed altered concentrations in blood in ASD compared with healthy control children and which were also correlated with symptom severity. Our study sample included 32 children diagnosed with ASD and 28 age and sex-matched typically developing children...
July 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28765956/anti-cd20-monoclonal-antibody-combined-with-adenovirus-vector-mediated-il-10-regulates-spleen-cd4-cd8-t%C3%A2-cells-and-t-bet-gata-3-expression-in-nod-mice
#17
Aiping Tang, Cheng Li, Zhihong Chen, Tang Li
Type 1 diabetes (T1D) is an autoimmune disease characterized by a selective destruction of insulin-secreting β-cells. Both T cells and B cells serve a crucial role in pathogenesis and development of T1D. CD20 is a specific membrane antigen of B lymphocytes, while interleukin (IL)‑10 is an important cytokine secreted by T helper 2 cells and has a short half‑life in vivo. The combined effect of anti‑CD20 and IL‑10 on immune function of mice with T1D remains unknown. In the present study, 30 non‑obese diabetic (NOD) mice were treated with anti‑CD20 and adenoviral vector‑mediated interleukin‑10 (Ad‑mIL‑10) therapy...
October 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28762530/high-proportion-of-pd-1-expressing-cd4-t-cells-in-adipose-tissue-constitutes-an-immunomodulatory-microenvironment-that-may-support-hiv-persistence
#18
Abderaouf Damouche, Guillaume Pourcher, Valérie Pourcher, Stéphane Benoist, Elodie Busson, Jean Jacques Lataillade, Mélanie Le Van, Thierry Lazure, Julien Adam, Benoit Favier, Bruno Vaslin, Michaela Müller-Trutwin, Olivier Lambotte, Christine Bourgeois
We and others have demonstrated that adipose tissue is a reservoir for HIV. Evaluation of the mechanisms responsible for viral persistence may lead to ways of reducing these reservoirs. Here, we evaluated the immune characteristics of adipose tissue in HIV-infected patients receiving antiretroviral therapy (ART) and in non-HIV-infected patients. We notably sought to determine whether adipose tissue's intrinsic properties and/or HIV induced alteration of the tissue environment may favour viral persistence. ART-controlled HIV infection was associated with a difference in the CD4/CD8 T-cell ratio and an elevated proportion of Treg cells in subcutaneous adipose tissue...
August 1, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28757362/dynamized-ethyl-alcohol-improves-immune-response-and-behavior-in-murine-infection-with-trypanosoma-cruzi
#19
Patrícia F Sandri, Angela R Portocarrero, Larissa Ciupa, Fabiana N Ferraz, Gislaine J Falkowski-Temporini, Willian N S Rodrigues, Érika C Ferreira, Denise L Aleixo, Silvana Marques de Araújo
AIM: To evaluate the effects of dynamized ethyl alcohol (Ethylicum)6cH and 30cH in mice infected with T. cruzi. METHODS: In a blind, randomized and controlled assay, 63 eight-week-old, Swiss, male mice, infected with IP (1400 trypomastigotes, T. cruzi-Y-strain), were allocated into groups: CNI-non-infected (n=12), CI-infected and non-treated (n=17), Et6cH-infected, treated with Ethylicum 6cH (dilution 1:10(12)) (n=17), Et30cH-infected, treated with Ethylicum 30cH (dilution 1:10(60)) (n=17)...
July 27, 2017: Cytokine
https://www.readbyqxmd.com/read/28756630/dna-methylation-of-th2-lineage-determination-genes-at-birth-is-associated-with-allergic-outcomes-in-childhood
#20
S J Barton, S Ngo, P Costello, E Garratt, S El-Heis, E Antoun, R Clarke-Harris, R Murray, T Bhatt, G Burdge, C Cooper, H Inskip, E M van der Beek, A Sheppard, K M Godfrey, K A Lillycrop
BACKGROUND: There is now increasing evidence that asthma and atopy originate in part in utero, with disease risk being associated with the altered epigenetic regulation of genes. OBJECTIVE AND METHODS: To determine the relationship between variations in DNA methylation at birth and the development of allergic disease, we examined the methylation status of CpG loci within the promoter regions of Th1/2 lineage commitment genes (GATA3, IL-4, IL-4R, STAT4 and TBET) in umbilical cord DNA at birth in a cohort of infants from the Southampton Women's Survey (n = 696) who were later assessed for asthma, atopic eczema and atopy...
July 30, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
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