Shaoming Xiao, Ahmed Abade, Waqo Boru, Watipaso Kasambara, John Mwaba, Francis Ongole, Mariam Mmanywa, Nídia Sequeira Trovão, Roma Chilengi, Geoffrey Kwenda, Christopher Garimoi Orach, Innocent Chibwe, Godfrey Bwire, O Colin Stine, Aaron M Milstone, Justin Lessler, Andrew S Azman, Wensheng Luo, Kelsey Murt, David A Sack, Amanda K Debes, Shirlee Wohl
Despite ongoing containment and vaccination efforts, cholera remains prevalent in many countries in sub-Saharan Africa. Part of the difficulty in containing cholera comes from our lack of understanding of how it circulates throughout the region. To better characterize regional transmission, we generated and analyzed 118 Vibrio cholerae genomes collected between 2007-2019 from five different countries in Southern and Eastern Africa. We showed that V. cholerae sequencing can be successful from a variety of sample types and filled in spatial and temporal gaps in our understanding of circulating lineages, including providing some of the first sequences from the 2018-2019 outbreaks in Uganda, Kenya, Tanzania, Zambia, and Malawi...
March 30, 2024: medRxiv