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https://www.readbyqxmd.com/read/28809473/aie-materials-with-different-electric-charges-as-artificial-tongue-design-construction-and-assembly-with-various-pathogenic-bacteria-for-effective-bacterial-imaging-and-discrimination
#1
Guang-Jian Liu, Sheng-Nan Tian, Cui-Yun Li, Guo-Wen Xing, Lei Zhou
Imaging-based total bacterial count and type identification of bacteria play crucial rules in clinical diagnostics, public health, biological and medical science, environmental protection. Herein, we designed and synthesized a series of tetraphenylethenes (TPEs) functionalized with one or two aldehyde, carboxylic acid and quaternary ammonium groups, which were successfully used as fluorescent materials for rapid and efficient staining of 8 kinds of representative bacterial species, including pathogenic bacteria Vibrio cholera, Klebsiella pneumoniae, Listeria monocytogenes and potential bioterrorism agent Yersinia pestis...
August 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28808998/microfluidics-mass-spectrometry-of-protein-carbohydrate-interactions-applications-to-the-development-of-therapeutics-and-biomarker-discovery
#2
Alina D Zamfir
The functional interactions of carbohydrates and their protein receptors are the basis of biological events critical to the evolution of pathological states. Hence, for the past years, such interactions have become the focus of research for the development of therapeutics and discovery of novel glycan biomarkers based on their binding affinity. Due to the high sensitivity, throughput, reproducibility, and capability to ionize minor species in heterogeneous mixtures, microfluidics-mass spectrometry (MS) has recently emerged as a method of choice in protein-glycan interactomics...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28808000/vibrio-cholerae-type-6-secretion-system-effector-trafficking-in-target-bacterial-cells
#3
Brian T Ho, Yang Fu, Tao G Dong, John J Mekalanos
The type 6 secretion system (T6SS) is used by many Gram-negative bacterial species to deliver toxic effector proteins into nearby bacteria prey cells to kill or inhibit their growth. VgrG proteins are core conserved secretion substrates of the T6SS and one subset of T6SS effectors consists of VgrG proteins with C-terminal extension domains carrying various enzymatic activities. In Vibrio cholerae, VgrG3 has a hydrolase extension domain and degrades peptidoglycan in the periplasm of target bacteria. In this study, we replaced this domain with a nuclease domain from Salmonella enterica subsp...
August 14, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28805465/what-we-are-watching-top-global-infectious-disease-threats-2013-2016-an-update-from-cdc-s-global-disease-detection-operations-center
#4
Kira A Christian, A Danielle Iuliano, Timothy M Uyeki, Eric D Mintz, Stuart T Nichol, Pierre Rollin, J Erin Staples, Ray R Arthur
To better track public health events in areas where the public health system is unable or unwilling to report the event to appropriate public health authorities, agencies can conduct event-based surveillance, which is defined as the organized collection, monitoring, assessment, and interpretation of unstructured information regarding public health events that may represent an acute risk to public health. The US Centers for Disease Control and Prevention's (CDC's) Global Disease Detection Operations Center (GDDOC) was created in 2007 to serve as CDC's platform dedicated to conducting worldwide event-based surveillance, which is now highlighted as part of the "detect" element of the Global Health Security Agenda (GHSA)...
August 14, 2017: Health Security
https://www.readbyqxmd.com/read/28803813/the-challenges-of-cholera-at-the-2017-hajj-pilgrimage
#5
Alimuddin Zumla, Brian McCloskey, Tina Endericks, Esam I Azhar, Eskild Petersen
No abstract text is available yet for this article.
August 10, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28803712/oral-cholera-vaccine-coverage-in-hard-to-reach-fishermen-communities-after-two-mass-campaigns-malawi-2016
#6
Delphine Sauvageot, Christel Saussier, Abebe Gobeze, Sikhona Chipeta, Innocent Mhango, Gift Kawalazira, Martin A Mengel, Dominique Legros, Philippe Cavailler, Maurice M'bang'ombe
CONTEXT: From December 2015 to August 2016, a large epidemic of cholera affected the fishermen of Lake Chilwa in Malawi. A first reactive Oral Cholera Vaccines (OCV) campaign was organized, in February, in a 2km radius of the lake followed by a preemptive one, conducted in November, in a 25km radius. We present the vaccine coverage reached in hard-to-reach population using simplified delivery strategies. METHOD: We conducted two-stage random-sampling cross-sectional surveys among individuals living in a 2km and 25km radius of Lake Chilwa (islands and floating homes included)...
August 10, 2017: Vaccine
https://www.readbyqxmd.com/read/28801549/great-cormorants-phalacrocorax-carbo-as-potential-vectors-for-the-dispersal-of-vibrio-cholerae
#7
Sivan Laviad-Shitrit, Tidhar Lev-Ari, Gadi Katzir, Yehonatan Sharaby, Ido Izhaki, Malka Halpern
Vibrio cholerae is the cause of cholera, a devastating epidemic and pandemic disease. Despite its importance, the way of its global dissemination is unknown. V. cholerae is abundant in aquatic habitats and is known to be borne by copepods, chironomids and fishes. Our aim was to determine if fish-eating birds act as vectors in the spread of V. cholerae by consuming infected fish. We determined the existence of V. cholerae in the microbiome of 5/7 wild cormorants' intestine. In three of these V. cholerae-positive wild cormorants, the presence of a gene for cholera toxin (ctxA) was detected...
August 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28799734/deployments-from-the-oral-cholera-vaccine-stockpile-2013%C3%A2-2017
#8
(no author information available yet)
No abstract text is available yet for this article.
August 11, 2017: Relevé épidémiologique Hebdomadaire
https://www.readbyqxmd.com/read/28798313/spatial-disease-dynamics-of-free-living-pathogens-under-pathogen-predation
#9
Tommi Mononen, Lasse Ruokolainen
The epidemiological dynamics of potentially free-living pathogens are often studied with respect to a specific pathogen species (e.g., cholera) and most studies concentrate only on host-pathogen interactions. Here we show that metacommunity-level interactions can alter conventional spatial disease dynamics. We introduce a pathogen eating consumer species and investigate a deterministic epidemiological model of two habitat patches, where both patches can be occupied by hosts, pathogens, and consumers of free-living pathogens...
August 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28797285/large-cholera-outbreak-in-brong-ahafo-region-ghana
#10
Charles Lwanga Noora, Kofi Issah, Ernest Kenu, Emmanuel George Bachan, Robert Domo Nuoh, Kofi Mensah Nyarko, Paulina Appiah, Timothy Letsa
BACKGROUND: A nationwide outbreak of Vibrio cholerae occurred in Ghana in 2014 with Accra, the nation's capital as the epi-center. The outbreak spread to the Brong Ahafo Region (BAR) which is geographically located in the middle of the country. In this region a review of data collected during the outbreak was carried out and analyzed descriptively to determine the hot spots and make recommendations for effective response to future outbreaks. METHODS: A review of patient records and line lists of cases of cholera reported in all hospitals during the period of the outbreak (July-December 2014) was conducted...
August 10, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28795725/rational-design-of-artificial-dye-decolorizing-peroxidases-using-myoglobin-by-engineering-tyr-trp-in-the-heme-center
#11
Le-Le Li, Hong Yuan, Fei Liao, Bo He, Shu-Qin Gao, Ge-Bo Wen, Xiangshi Tan, Ying-Wu Lin
The rational design of metalloenzymes provides advantages not only for illustrating the structure and function relationship of native enzymes, but also for creating functional artificial enzymes comparable to native enzymes. Dye-decolorizing peroxidases (DyPs) are a new family of heme peroxidases and have received much attention recently. Inspired by the structural features of native DyPs with multiple Tyr and Trp residues, we herein aimed to design functional artificial DyPs using myoglobin (Mb), an O2 carrier as a protein scaffold, by further introduction of Tyr/Trp into the secondary sphere of the heme center in the F43Y Mb mutant...
August 10, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28792540/antibiotics-resistance-in-el-tor-vibrio-cholerae-01-isolated-during-cholera-outbreaks-in-mozambique-from-2012-to-2015
#12
Liliana Candida Dengo-Baloi, Cynthia Amino Semá-Baltazar, Lena Vania Manhique, Jucunu Elias Chitio, Dorteia Luísa Inguane, José Paulo Langa
RATIONALE: Mozambique has recorded cyclically epidemic outbreaks of cholera. Antibiotic therapy is recommended in specific situations for management and control of cholera outbreaks. However, an increase in resistance rates to antibiotics by Vibrio cholerae has been reported in several epidemic outbreaks worldwide. On the other hand, there are few recent records of continuous surveillance of antibiotics susceptibility pattern of V. cholerae in Mozambique. GOALS: The purpose of this study was to evaluate antibiotics resistance pattern of Vibrio cholerae O1 Ogawa isolated during Cholera outbreaks in Mozambique to commonly used antibiotics...
2017: PloS One
https://www.readbyqxmd.com/read/28782352/cornus-mas-a-review-on-traditional-uses-and-pharmacological-properties
#13
Fatemeh Hosseinpour-Jaghdani, Tahoora Shomali, Sajedeh Gholipour-Shahraki, Mohammad Rahimi-Madiseh, Mahmoud Rafieian-Kopaei
Medicinal plants that are used today have been known by people of ancient cultures around the world and have largely been considered due to their medicinal properties. Cornus mas L. (Cornelian cherry) is one of these medicinal plants with high level of antioxidant activity. Cornelian cherry is an attractive ornamental plant with delicious fruit having nutritional and therapeutic values. The main purpose of this paper is to present and summarize the pharmacological and therapeutic effects from researches done on Cornelian cherry in studies from 2000 to 2016...
March 31, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/28780738/john-p-craig-md-mph-physician-scientist-educator-and-mentor-1923-2016
#14
M A Haseeb, Pascal James Imperato
John P. Craig (1923-2016) was an eminent physician-scientist, gifted educator, and greatly valued mentor. Born in West Liberty, Ohio on 29 November 1923, he attended Oberlin College, and received his medical degree from Case Western Reserve University, School of Medicine. This was followed by an internship at Yale University Medical Center, and then service in the U.S. Army during the Korean War. He was a battalion surgeon, preventive medicine officer, and epidemiologist. While in Korea, he conducted important investigations of hemorrhagic fever among American troops...
August 5, 2017: Journal of Community Health
https://www.readbyqxmd.com/read/28780344/selection-of-affinity-peptides-for-interference-free-detection-of-cholera-toxin
#15
Jong Min Lim, Nam Su Heo, Seo Yeong Oh, Myung Yi Ryu, Jeong Hyun Seo, Tae Jung Park, Yun Suk Huh, Jong Pil Park
Cholera toxin is a major virulent agent of Vibrio cholerae, and it can rapidly lead to severe dehydration, shock, causing death within hours without appropriate clinical treatments. In this study, we present a method wherein unique and short peptides that bind to cholera toxin subunit B (CTX-B) were selected through M13 phage display. Biopanning over recombinant CTX-B led to rapid screening of a unique peptide with an amino acid sequence of VQCRLGPPWCAK, and the phage-displayed peptides analyzed using ELISA, were found to show specific affinities towards CTX-B...
July 31, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28774322/tau-accumulation-in-the-retina-promotes-early-neuronal-dysfunction-and-precedes-brain-pathology-in-a-mouse-model-of-alzheimer-s-disease
#16
Marius Chiasseu, Luis Alarcon-Martinez, Nicolas Belforte, Heberto Quintero, Florence Dotigny, Laurie Destroismaisons, Christine Vande Velde, Fany Panayi, Caroline Louis, Adriana Di Polo
BACKGROUND: Tau is an axon-enriched protein that binds to and stabilizes microtubules, and hence plays a crucial role in neuronal function. In Alzheimer's disease (AD), pathological tau accumulation correlates with cognitive decline. Substantial visual deficits are found in individuals affected by AD including a preferential loss of retinal ganglion cells (RGCs), the neurons that convey visual information from the retina to the brain. At present, however, the mechanisms that underlie vision changes in these patients are poorly understood...
August 3, 2017: Molecular Neurodegeneration
https://www.readbyqxmd.com/read/28774176/spectrally-resolved-functional-super-resolution-microscopy-reveals-nanoscale-compositional-heterogeneity-in-live-cell-membranes
#17
Seonah Moon, Rui Yan, Samuel J Kenny, Yennie Shyu, Limin Xiang, Wan Li, Ke Xu
By recording the full fluorescence spectra and super-resolved positions of ∼10(6) individual polarity-sensing solvatochromic molecules, we reveal compositional heterogeneity in the membranes of live mammalian cells with single-molecule sensitivity and ∼30 nm spatial resolution. This allowed us to unveil distinct polarity characteristics of the plasma membrane and the membranes of nanoscale intracellular organelles, a result we found to be due to differences in cholesterol levels. Within the plasma membrane, we observed the formation of low-polarity, raft-like nanodomains upon cholesterol addition or cholera-toxin treatment, but found this nanoscale phase separation absent in native cells...
August 16, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28774152/ultrasensitive-biosensor-for-the-detection-of-vibrio-cholerae-dna-with-polystyrene-co-acrylic-acid-composite-nanospheres
#18
Mahbubur Rahman, Lee Yook Heng, Dedi Futra, Tan Ling Ling
An ultrasensitive electrochemical biosensor for the determination of pathogenic Vibrio cholerae (V. cholerae) DNA was developed based on polystyrene-co-acrylic acid (PSA) latex nanospheres-gold nanoparticles composite (PSA-AuNPs) DNA carrier matrix. Differential pulse voltammetry (DPV) using an electroactive anthraquninone oligonucleotide label was used for measuring the biosensor response. Loading of gold nanoparticles (AuNPs) on the DNA-latex particle electrode has significantly amplified the faradaic current of DNA hybridisation...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28771717/organizational-connectivity-among-the-ca1-subiculum-presubiculum-and-entorhinal-cortex-in-the-rabbit
#19
Yoshiko Honda, Hideshi Shibata
The laminar and topographical organization of connections between the hippocampal formation and parahippocampal regions was investigated in the rabbit following in vivo injection of cholera toxin B subunit as a retro- and anterograde tracer and biotinylated dextran amine as an anterograde tracer. We confirmed several connectional features different from those of the rat, i.e., the rabbit presubiculum received abundant afferents from CA1 and had many reciprocal connections with the entorhinal cortex. On the other hand, we identified many similarities with the rat: both the CA1 and subicular afferents that originated from the entorhinal cortex were abundant; moreover, the presubiculum received many inputs from the subiculum and sent massive projections to the entorhinal cortex...
August 2, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28768095/investigating-the-influence-of-membrane-composition-on-protein-glycolipid-binding-using-nanodiscs-and-proxy-ligand-esi-ms
#20
Ling Han, Luis Morales, Michele R Richards, Elena N Kitova, Simonetta Sipione, John S Klassen
This work describes a versatile analytical approach, which combines the proxy ligand electrospray ionization mass spectrometry (ESI-MS) assay and model membranes of defined composition, to quantify the influence of lipid bilayer composition on protein-glycolipid binding in vitro. To illustrate the implementation of the assay (experimental design and data analysis), affinities of the monosialoganglioside ligand GM1, incorporated into nanodiscs (NDs), for cholera toxin B subunit homopentamer (CTB5) were measured...
August 2, 2017: Analytical Chemistry
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