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Niaz Ali, Robina Begum, Muhammad Saleh Faisal, Aslam Khan, Muhammad Nabi, Gulfam Shehzadi, Shakir Ullah, Waqar Ali
BACKGROUND: Statins are used for treatment of hypercholestremia. Common adverse reports associated with use of statins are generalized bodyache, rhabdomyolysis, muscles weakness and gastrointestinal disorders. The current work is an attempt to explain how smooth muscles of gastrointestinal tissues are affected by the current statins (Simvastatin, atorvastatin, fluvastatin and rosuvastatin). METHODS: Effects of the current statins were studied on spontaneous activity of isolated rabbits' jejunal preparations...
September 21, 2016: BMC Pharmacology & Toxicology
Michael E El-Kommos, Niveen A Mohamed, Hassan R H Ali, Ahmed F Abdel Hakiem
A specific, accurate, precise and reproducible micellar electrokinetic chromatographic method was developed for in vitro and in vivo estimation of rosuvastatin, a synthetic and potent HMG-CoA inhibitor, in rabbit plasma. Further, its pharmacokinetics in the presence of niacin, which could be co-administered for monitoring of severe hypercholestremia, was investigated. The assay procedures involved simple liquid-liquid extraction of rosuvastatin and internal standard, atorvastatin, from a small plasma volume directly into acetonitrile...
December 2014: Biomedical Chromatography: BMC
Shilpa N Kaore, Hanmant S Amane, Navinchandra M Kaore
L-Citrulline is a naturally occurring non-essential amino acid, an intermediate in urea cycle and conditionally essential in intestinal pathology. It is a potent hydroxyl radical scavenger and much more effective precursor of arginine and nitric oxide (NO) than arginine itself so exploited in therapeutics. Plasma citrulline concentration is used by clinicians to assess functional enterocyte mass in various chronic and acute small bowel pathologies like short bowel syndrome that has become an indication in clinical practice...
February 2013: Fundamental & Clinical Pharmacology
Asya A Al Riyami, Mustafa M Afifi
BACKGROUND: International studies have reported increased prevalence of hypertension and other cardiovascular risk factors, Our aim was to study the distribution and the correlates of hypertension (HTN - systolic or diastolic) in a community based survey (National Health Survey, 2000). METHODS: A cross-sectional survey of the health status of Omani community was designed. Face to face interview including demographic data, blood pressure measurement, fasting blood glucose and serum cholesterol, weight, height, waist and hip measurement for 7011 Omani subjects with a response rate ranging between about 83% (for fasting blood glucose) to about 91% (for blood pressure measurement)...
2002: Journal of the Egyptian Public Health Association
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July 6, 1964: Polski Tygodnik Lekarski
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