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Germany National Cohort

Ilan Youngster, Jerry Avorn, Valeria Belleudi, Anna Cantarutti, Javier Díez-Domingo, Ursula Kirchmayer, Byung-Joo Park, Salvador Peiró, Gabriel Sanfélix-Gimeno, Helmut Schröder, Katrin Schüssel, Ju-Young Shin, Sun Mi Shin, Gunnar Skov Simonsen, Hege Salvesen Blix, Angela Tong, Gianluca Trifirò, Tomer Ziv-Baran, Seoyoung C Kim
OBJECTIVES: To describe the rates of pediatric antibiotic use across 6 countries on 3 continents. STUDY DESIGN: Cross-national analysis of 7 pediatric cohorts in 6 countries (Germany, Italy, South Korea, Norway, Spain, and the US) was performed for 2008-2012. Antibiotic dispensings were identified and grouped into subclasses. We calculated the rates of antimicrobial prescriptions per person-year specific to each age group, comparing the rates across different countries...
December 19, 2016: Journal of Pediatrics
Claudia Diederichs, Hannelore Neuhauser
OBJECTIVE: To analyze incident hypertension and its risk factors based on 11.9 years follow-up of a recent National Examination Survey cohort in Germany. METHODS: Out of 7124 participants of the German National Health Interview and Examination Survey 1998 (GNHIES98), 640 had died at follow-up 2008-2011 and 3045 were reexamined as part of the German Health Interview and Examination Survey for Adults 2008-2011 (DEGS1). Baseline and follow-up included standardized blood pressure (BP) measurements...
February 2017: Journal of Hypertension
Daniela Varges, Henrike Manthey, Uta Heinemann, Claudia Ponto, Matthias Schmitz, Walter J Schulz-Schaeffer, Anna Krasnianski, Maren Breithaupt, Fabian Fincke, Katharina Kramer, Tim Friede, Inga Zerr
OBJECTIVES: The main objective of the present study is to study the therapeutic efficiency of doxycycline in a double-blinded randomised phase II study in a cohort of patients with sporadic Creutzfeldt-Jakob disease (sCJD). METHODS: From the National Reference Center of TSE Surveillance in Germany, patients with probable or definite sCJD were recruited for a double-blinded randomised study with oral doxycycline (EudraCT 2006-003934-14). In addition, we analysed the data from patients with CJD who received compassionate treatment with doxycycline in a separate group...
November 2, 2016: Journal of Neurology, Neurosurgery, and Psychiatry
Ralf A Linker, Guillaume Wendt
INTRODUCTION: Fingolimod was the first oral therapy approved for the treatment of relapsing-remitting multiple sclerosis (RRMS). Due to its action on cardiac sphingosine 1-phosphate receptors, fingolimod is leading to a transient decrease in heart rate (HR) and the occurrence of rare and asymptomatic self-limited atrioventricular (AV) blocks. This German non-interventional clinical study aimed to assess the cardiac safety profile in RRMS patients during at least 6 h after the initial treatment or restart after interruption of fingolimod in real-world settings...
December 2016: Neurology and Therapy
Nemanja Vaci, Merim Bilalić
The game of chess has often been used for psychological investigations, particularly in cognitive science. The clear-cut rules and well-defined environment of chess provide a model for investigations of basic cognitive processes, such as perception, memory, and problem solving, while the precise rating system for the measurement of skill has enabled investigations of individual differences and expertise-related effects. In the present study, we focus on another appealing feature of chess-namely, the large archive databases associated with the game...
September 1, 2016: Behavior Research Methods
Peter Ahnert, Petra Creutz, Markus Scholz, Hartwig Schütte, Christoph Engel, Hamid Hossain, Trinad Chakraborty, Michael Bauer, Michael Kiehntopf, Uwe Völker, Sven Hammerschmidt, Markus Loeffler, Norbert Suttorp
BACKGROUND: Community acquired pneumonia (CAP) is a high incidence disease resulting in about 260,000 hospital admissions per year in Germany, more than myocardial infarction or stroke. Worldwide, CAP is the most frequent infectious disease with high lethality ranging from 1.2 % in those 20-29 years old to over 10 % in patients older than 70 years, even in industrial nations. CAP poses numerous medical challenges, which the PROGRESS (Pneumonia Research Network on Genetic Resistance and Susceptibility for the Evolution of Severe Sepsis) network aims to tackle: Operationalization of disease severity throughout the course of disease, outcome prediction for hospitalized patients and prediction of transitions from uncomplicated CAP to severe CAP, and finally, to CAP with sepsis and organ failure as a life-threatening condition...
July 28, 2016: BMC Pulmonary Medicine
Michael E O'Keeffe, Tarek N Hanna, Davis Holmes, Olivia Marais, Mohammed F Mohammed, Sheldon Clark, Patrick McLaughlin, Savvas Nicolaou, Faisal Khosa
Bibliometric analysis is the application of statistical methods to analyze quantitative data about scientific publications. It can evaluate research performance, author productivity, and manuscript impact. To the best of our knowledge, no bibliometric analysis has focused on cardiac computed tomography (CT). The purpose of this paper was to compile a list of the 100 most-cited articles related to cardiac CT literature using Scopus and Web of Science (WOS). A list of the 100 most-cited articles was compiled by order of citation frequency, as well a list of the top 10 most-cited guideline and review articles and the 20 most-cited articles of the years 2014-2015...
September 2016: Journal of Cardiovascular Computed Tomography
Young-Woo Kim, Jungnam Joo, Hong Man Yoon, Bang Wool Eom, Keun Won Ryu, Il Ju Choi, Myeong Cherl Kook, Christoph Schuhmacher, Joerg Ruediger Siewert, Daniel Reim
Several retrospective analyses on patients who underwent gastric cancer (GC) surgery revealed different survival outcomes between Eastern (Korean, Japanese) and Western (USA, Europe) countries due to potential ethnical and biological differences. This study investigates treatment outcomes between specialized institution for GC in Korea and Germany.The prospectively documented databases of the Gastric Cancer Center of the National Cancer Center, Korea (NCCK) and the Department of Surgery of the Technische Universitaet Muenchen (TUM), Germany were screened for patients who underwent primary surgical resection for GC between 2002 and 2008...
July 2016: Medicine (Baltimore)
Petra Temming, Marina Arendt, Anja Viehmann, Lewin Eisele, Claudia H D Le Guin, Michael M Schündeln, Eva Biewald, Jennifer Mäusert, Regina Wieland, Norbert Bornfeld, Wolfgang Sauerwein, Angelika Eggert, Dietmar R Lohmann, Karl-Heinz Jöckel
PURPOSE: Intraocular retinoblastoma is curable, but survivors with a heritable predisposition are at high risk for second malignancies. Because second malignancies are associated with high mortality, prognostic factors for second malignancy influence long-term overall survival. This study investigates the impact of all types of eye-preserving therapies on long-term survival in the complete German cohort of patients with heritable retinoblastoma. PATIENTS AND METHODS: Overall survival, disease staging using international scales, time period of diagnosis, and treatment type were analyzed in the 633 German children treated at the national reference center for heritable retinoblastoma...
September 10, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Chad Logan, Tatjana Zittel, Stefanie Striebel, Frank Reister, Hermann Brenner, Dietrich Rothenbacher, Jon Genuneit
BACKGROUND: Breastfeeding is an important determinant of early infant immune function and potentially future health. Although numerous studies have reported rising breastfeeding initiation rates and duration, few longitudinally investigated the impact of shifting societal and lifestyle factors on breastfeeding patterns in developed nations. METHODS: The Ulm Birth Cohort Study (UBCS) and Ulm SPATZ Health Study (SPATZ) cohorts consist of newborns and their mothers recruited, respectively, from 2000 to 2001 and 2012 to 2013 at the University Medical Center Ulm, Germany...
May 2016: Pediatrics
C L Schlett, T Hendel, S Weckbach, M Reiser, H U Kauczor, K Nikolaou, M Günther, M Forsting, N Hosten, H Völzke, F Bamberg
UNLABELLED: The MRI study within the German National Cohort, a large-scale, population-based, longitudinal study in Germany, comprises comprehensive characterization and phenotyping of a total of 30 000 participants using 3-Tesla whole-body MR imaging. A multi-centric study design was established together with dedicated core facilities for e. g. managing incidental findings or providing quality assurance. As such, the study represents a unique opportunity to substantially impact imaging-based risk stratification leading to personalized and precision medicine...
July 2016: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
Laura Mariani, Bénédicte Stengel, Christian Combe, Ziad A Massy, Helmut Reichel, Danilo Fliser, Roberto Pecoits-Filho, Antonio A Lopes, Kunihiro Yamagata, Takashi Wada, Michelle M Y Wong, Elodie Speyer, Friedrich K Port, Ronald L Pisoni, Bruce M Robinson
BACKGROUND: Minimizing clinical complications in patients with advanced chronic kidney disease (CKD) and improving the transition to dialysis therapy and transplantation represents a challenge, requiring reliable evidence regarding the effects of CKD care on outcomes. STUDY DESIGN: The CKD Outcomes and Practice Patterns Study (CKDopps) is a new international prospective cohort study designed to describe and evaluate variation in nephrologist-led CKD practices. SETTING & PARTICIPANTS: CKDopps is underway in Brazil, France, Germany, Japan, and the United States...
September 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
B Kuntz, T Lampert
Background: Maternal smoking during pregnancy represents a significant developmental risk for the unborn child. This study investigated social differences in maternal smoking behavior during pregnancy in mothers living in Germany. The study focused on maternal age at delivery, social status and migration background. Method: The evaluation of data was based on two surveys carried out as part of the German Health Interview and Examination Survey for Children and Adolescents (KiGGS) carried out in 2003-2006 and in 2009-2012...
March 2016: Geburtshilfe und Frauenheilkunde
Ulrich John, Monika Hanke
BACKGROUND: A decrease in lung cancer mortality among females below 50 years of age has been reported for countries with significant tobacco control efforts. The aim of this study was to describe the lung cancer deaths, including the mortality rates and proportions among total deaths, for females and males by age at death in a country with a high smoking prevalence (Germany) over a time period of 62 years. METHODS: The vital statistics data were analyzed using a joinpoint regression analysis stratified by age and sex...
March 25, 2016: International Journal of Environmental Research and Public Health
Christian J Bachmann, Lise Aagaard, Mehmet Burcu, Gerd Glaeske, Luuk J Kalverdijk, Irene Petersen, Catharina C M Schuiling-Veninga, Linda Wijlaars, Julie M Zito, Falk Hoffmann
Following the FDA black box warning in 2004, substantial reductions in antidepressant (ATD) use were observed within 2 years in children and adolescents in several countries. However, whether these reductions were sustained is not known. The objective of this study was to assess more recent trends in ATD use in youth (0-19 years) for the calendar years 2005/6-2012 using data extracted from regional or national databases of Denmark, Germany, the Netherlands, the United Kingdom (UK), and the United States (US)...
March 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
Claudia Michalik, Adriane Skaletz-Rorowski, Norbert H Brockmeyer
BACKGROUND: With funding for the Competence Networks in Medicine from the Federal Ministry of Education and Research, the Competence Network for HIV/AIDS (KompNet HIV/AIDS) was established as an interdisciplinary research association. Essential working groups were incorporated all over Germany, which are active in clinical and basic HIV/AIDS research. OBJECTIVES: After successful establishment, providing research infrastructure for national and international cooperation in the field of HIV/AIDS was the focus of the network...
April 2016: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
Harald Schrem, Moritz Focken, Bridget Gunson, Benedikt Reichert, Darius Mirza, Hans-Heinrich Kreipe, Desley Neil, Alexander Kaltenborn, Alon Goldis, Christian Krauth, Keith Roberts, Thomas Becker, Jürgen Klempnauer, James Neuberger
Prognostic models for the prediction of 90-day mortality after transplantation with pretransplant donor and recipient variables are needed to calculate transplant benefit. Transplants in adult recipients in Germany (Hannover, n = 770; Kiel, n = 234) and the United Kingdom (Birmingham, n = 829) were used for prognostic model design and validation in separate training and validation cohorts. The survival benefit of transplantation was estimated by subtracting the observed posttransplant 90-day mortality from the expected 90-day mortality without transplantation determined by the Model for End-Stage Liver Disease (MELD) score...
June 2016: Liver Transplantation
Maria Gose, Carolin Krems, Thorsten Heuer, Ingrid Hoffmann
The German National Nutrition Monitoring (NEMONIT) is a longitudinal and nationwide study to assess changes in food consumption and nutrient intake in Germany. A sample of 1840 participants (baseline age: 14-80 years) was drawn from the nationally representative German National Nutrition Survey (NVS) II (2005-2007). The participants have been interviewed by telephone annually since 2008. Food consumption was assessed by two 24-h recalls in the NVS II and the 4 years of NEMONIT (2008-2012/2013), respectively...
April 2016: British Journal of Nutrition
Shoma Berkemeyer, Dorothea Lemke, Hans Werner Hense
Longitudinal analysis investigates period (P), often as years. Additional scales of time are age (A) and birth cohort (C) Aim of our study was to use ecological APC analysis for women breast cancer incidence and mortality in Germany. Nation-wide new cases and deaths were obtained from Robert Koch Institute and female population from federal statistics, 1999-2008. Data was stratified into ten 5-years age-groups starting 20-24 years, ten birth cohorts starting 1939-43, and two calendar periods 1999-2003 and 2004-2008...
2016: PloS One
Guido Schäfer, Benno Kreuels, Stefan Schmiedel, Sandra Hertling, Anja Hüfner, Olaf Degen, Jan van Lunzen, Julian Schulze Zur Wiesch
165 treatment-naive patients who first presented at the infectious disease clinic of the University Medical Center Hamburg-Eppendorf from 2009 to 2011 were retrospectively analyzed with emphasis on patients with late presentation (LP). In line with other recent German reports, there was a large proportion of 105 of the 165 treatment-naïve patients (63.6 %) who presented late. Old age, heterosexual transmission risk and migrant background were associated risk factors for late presentation. Thus, further intensified national efforts like the HIV in Europe initiative are needed to identify such patients at high risk for HIV infection...
June 2016: Infection
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