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Germany National Cohort

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https://www.readbyqxmd.com/read/29757414/vaccination-coverage-in-systemic-lupus-erythematosus-a-cross-sectional-analysis-of-the-german-long-term-study-lula-cohort
#1
Gamal Chehab, Jutta G Richter, Ralph Brinks, Rebecca Fischer-Betz, Borgi Winkler-Rohlfing, Matthias Schneider
Objectives: Vaccinations are an important measure to prevent infections in immunocompromised patients. The knowledge of vaccination coverage and reasons for non-vaccination in patients with SLE is scarce. The aim of this study was to assess coverage rates of selected vaccinations in a representative sample of SLE patients and to identify predictors for non-vaccination. Methods: In 2013, information on selected vaccinations (coverage, application and reservations) and on demographics, clinical parameters and health beliefs was assessed by means of a self-reported questionnaire among a representative sample of SLE patients in Germany (LuLa cohort)...
May 10, 2018: Rheumatology
https://www.readbyqxmd.com/read/29743332/predictors-of-physical-activity-among-older-adults-in-germany-a-nationwide-cohort-study
#2
Kristin Manz, Gert B M Mensink, Susanne Jordan, Anja Schienkiewitz, Susanne Krug, Jonas D Finger
OBJECTIVES: To investigate individual, interpersonal and environmental baseline factors predicting regular aerobic physical activity (PA) participation among older adults in Germany at follow-up 12 years later. DESIGN: Population-based cohort study. SETTING: Cluster-randomised general population sample selected based on population registry address information from 130 nationally distributed sample points collected from 1997 to 1999 and re-evaluated 12 years later from 2008 to 2011...
May 9, 2018: BMJ Open
https://www.readbyqxmd.com/read/29729105/cost-effectiveness-of-secukinumab-as-first-biologic-treatment-compared-with-other-biologics-for-moderate-to-severe-psoriasis-in-germany
#3
Matthias Augustin, Doreen McBride, Isabelle Gilloteau, Caitriona O'Neill, Katja Neidhardt, Christopher N Graham
BACKGROUND: Secukinumab, a fully human monoclonal antibody that selectively neutralizes interleukin-17A, has demonstrated strong and sustained efficacy in adults with moderate to severe psoriasis in clinical trials. OBJECTIVE: This analysis compared the cost per responder of secukinumab as first biologic treatment of moderate to severe psoriasis, with adalimumab, infliximab, etanercept, and ustekinumab in Germany. METHODS: A 52-week decision-tree model was developed...
May 5, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29676618/cancer-risk-from-paediatric-computed-tomography-scanning-implications-for-radiation-protection-in-medicine
#4
A Kesminiene, E Cardis
The use of computed tomography (CT) imaging is clearly beneficial for millions of patients. However, the potential adverse health effects, particularly cancer, of ionising radiation exposure from CT early in life are an issue of growing concern in the radiological protection, medical, and public health communities. Although efforts to quantify these effects have been conducted, the precision and accuracy of reported risks needs confirmation. EPI-CT, a European collaborative epidemiological study, was set up to quantify risks from paediatric CT to optimise paediatric diagnostic protocol...
January 1, 2018: Annals of the ICRP
https://www.readbyqxmd.com/read/29642858/vaginal-birth-after-caesarean-versus-elective-repeat-caesarean-delivery-after-one-previous-caesarean-section-a-cost-effectiveness-analysis-in-four-european-countries
#5
Maaike Fobelets, Katrien Beeckman, Gilles Faron, Déirdre Daly, Cecily Begley, Koen Putman
BACKGROUND: The OptiBIRTH study incorporates a multicentre cluster randomised trial in 15 hospital sites across three European countries. The trial was designed to test a complex intervention aimed at improving vaginal birth after caesarean section (VBAC) rates through increasing women's involvement in their care. Prior to developing a robust standardised model to conduct the health economic analysis, an analysis of a hypothetical cohort was performed to estimate the costs and health effects of VBAC compared to elective repeat caesarean delivery (ERCD) for low-risk women in four European countries...
April 11, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29621309/diabetic-retinopathy-screening-in-incident-diabetes-mellitus-type-2-in-germany-between-2004-and-2013-a-prospective-cohort-study-based-on-health-claims-data
#6
Daniel Kreft, Myra B McGuinness, Gabriele Doblhammer, Robert P Finger
OBJECTIVE: To assess factors associated with diabetic retinopathy (DR) screening uptake following a diagnosis of type 2 diabetes mellitus (type 2 diabetes) in Germany. MATERIALS AND METHODS: A nationally representative prospective sample of individual-level health claims data for 250,000 members from Germany's largest public insurance provider in 2004-2013 was assessed. In the sample, 26,560 persons with incident type 2 diabetes were identified. Factors associated with subsequent DR screening were assessed using descriptive statistics, Kaplan-Meier estimator, and Cox regression analysis...
2018: PloS One
https://www.readbyqxmd.com/read/29567826/treatment-and-survival-of-patients-with-colon-cancer-aged-80-years-and-older-a-eurecca-international-comparison
#7
Nina C A Vermeer, Yvette H M Claassen, Marloes G M Derks, Lene H Iversen, Elizabeth van Eycken, Marianne G Guren, Pawel Mroczkowski, Anna Martling, Robert Johansson, Tamara Vandendael, Arne Wibe, Bjorn Moller, Hans Lippert, Johanneke E A Portielje, Gerrit Jan Liefers, Koen C M J Peeters, Cornelis J H van de Velde, Esther Bastiaannet
BACKGROUND: Colon cancer in older patients represents a major public health issue. As older patients are hardly included in clinical trials, the optimal treatment of these patients remains unclear. The present international EURECCA comparison explores possible associations between treatment and survival outcomes in elderly colon cancer patients. SUBJECTS, MATERIALS, AND METHODS: National data from Belgium, Denmark, The Netherlands, Norway, and Sweden were obtained, as well as a multicenter surgery cohort from Germany...
March 22, 2018: Oncologist
https://www.readbyqxmd.com/read/29539650/-class-climate-academic-well-being-and-self-rated-health-among-school-children-in-germany-findings-of-the-national-educational-panel-study-neps
#8
Katharina Rathmann, Max Herke, Klaus Hurrelmann, Matthias Richter
OBJECTIVES: The aim of this study was to examine the associations between features of class climate and school wellbeing, based on self-rated health and reports of absence from school due to illness among adolescents in secondary schools, by using data from the German National Educational Panel Study (NEPS). METHODS: Data was obtained from the National Educational Panel Study (NEPS). The sample includes (n=7,348) seventh grade students in regular schools (Starting Cohort 3, Wave 3, 2012)...
April 2018: Das Gesundheitswesen
https://www.readbyqxmd.com/read/29518133/icu-mortality-following-icu-acquired-primary-bloodstream-infections-according-to-the-type-of-pathogen-a-prospective-cohort-study-in-937-germany-icus-2006-2015
#9
Frank Schwab, Christine Geffers, Michael Behnke, Petra Gastmeier
OBJECTIVE: Mortality due to intensive care unit (ICU) acquired primary blood stream infections (PBSI) is related primarily to patient co-morbidities, types of pathogens and quality of care. The objective of this study is to determine the impact of various types of pathogen on ICU mortality. METHODS: Data from the German National Nosocomial Infection Surveillance System of patients with PBSI from 2006 to 2015 was used for this analysis. A BSI is primary when the pathogen recognized is not related to an infection on another site...
2018: PloS One
https://www.readbyqxmd.com/read/29506468/who-is-the-gate-keeper-for-treatment-in-a-fertility-clinic-in-germany-baseline-results-of-a-prospective-cohort-study-pink-study
#10
Eva Münster, Stephan Letzel, Jasmin Passet-Wittig, Norbert F Schneider, Bettina Schuhrke, Rudolf Seufert, Ulrike Zier
BACKGROUND: It is estimated that 5-15% of all couples in industrialised nations are infertile. A perceived unfulfilled desire for a child or self-identification as infertile can lead to psychological strain and social isolation. About 53.000 women underwent assisted reproduction treatments in Germany in 2014. Little is known about the first medical consultation and patient needs prior to the first visit in a fertility clinic in Germany. The baseline survey of the prospective cohort study on couples undergoing fertility treatment in Germany (PinK Study) provides first results on this topic for Germany...
March 5, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29452685/behavioural-outcomes-of-subthalamic-stimulation-and-medical-therapy-versus-medical-therapy-alone-for-parkinson-s-disease-with-early-motor-complications-earlystim-trial-secondary-analysis-of-an-open-label-randomised-trial
#11
Eugénie Lhommée, Lars Wojtecki, Virginie Czernecki, Karsten Witt, Franziska Maier, Lisa Tonder, Lars Timmermann, Thomas D Hälbig, Fanny Pineau, Franck Durif, Tatiana Witjas, Marcus Pinsker, Maximilian Mehdorn, Friederike Sixel-Döring, Andreas Kupsch, Rejko Krüger, Saskia Elben, Stephan Chabardès, Stéphane Thobois, Christine Brefel-Courbon, Fabienne Ory-Magne, Jean-Marie Regis, David Maltête, Anne Sauvaget, Jörn Rau, Alfons Schnitzler, Michael Schüpbach, Carmen Schade-Brittinger, Gunther Deuschl, Jean-Luc Houeto, Paul Krack
BACKGROUND: Although subthalamic stimulation is a recognised treatment for motor complications in Parkinson's disease, reports on behavioural outcomes are controversial, which represents a major challenge when counselling candidates for subthalamic stimulation. We aimed to assess changes in behaviour in patients with Parkinson's disease receiving combined treatment with subthalamic stimulation and medical therapy over a 2-year follow-up period as compared with the behavioural evolution under medical therapy alone...
March 2018: Lancet Neurology
https://www.readbyqxmd.com/read/29415580/a-non-interventional-comparative-study-of-the-20-1-combination-of-cafedrine-theodrenaline-versus-ephedrine-for-the-treatment-of-intra-operative-arterial-hypotension-the-hypotens-study-design-and-rationale
#12
Leopold Eberhart, Götz Geldner, Susanne Huljic, Kerstin Marggraf, Thomas Keller, Tilo Koch, Peter Kranke
OBJECTIVE: To compare the effectiveness of 20:1 cafedrine/theodrenaline approved for use in Germany to ephedrine in the restoration of arterial blood pressure and on post-operative outcomes in patients with intra-operative arterial hypotension of any origin under standard clinical practice conditions. METHODS AND RESULTS: 'HYPOTENS' is a national, multi-center, prospective, open-label, two-armed, non-interventional study. Effectiveness and post-operative outcome following cafedrine/theodrenaline or ephedrine therapy will be evaluated in two cohorts of hypotensive patients...
February 28, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29404652/increased-injury-rates-after-the-restructure-of-germany-s-national-second-league-of-team-handball
#13
Patrick Luig, Werner Krutsch, Michael Nerlich, Thomas Henke, Christian Klein, Hendrik Bloch, Petra Platen, Leonard Achenbach
PURPOSE: Scientific injury data in men's professional team handball injuries are rare and even less scientific information exists on injury prevention. In 2011, Germany's national second team handball league was restructured by merging the existing two regional leagues into one league. This study evaluates the injury patterns in professional team handball and compares the injury rates between the first and second league before and after the restructure. METHODS: All players of Germany's national first and second men's team handball leagues have mandatory trauma insurance with the same insurance company...
February 5, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29391658/stochastic-forecasting-of-labor-supply-and-population-an-integrated-model
#14
Johann Fuchs, Doris Söhnlein, Brigitte Weber, Enzo Weber
This paper presents a stochastic model to forecast the German population and labor supply until 2060. Within a cohort-component approach, our population forecast applies principal components analysis to birth, mortality, emigration, and immigration rates, which allows for the reduction of dimensionality and accounts for correlation of the rates. Labor force participation rates are estimated by means of an econometric time series approach. All time series are forecast by stochastic simulation using the bootstrap method...
2018: Population Research and Policy Review
https://www.readbyqxmd.com/read/29382225/provision-of-assistive-technology-devices-among-people-with-als-in-germany-a-platform-case-management-approach
#15
Andreas Funke, Susanne Spittel, Torsten Grehl, Julian Grosskreutz, Dagmar Kettemann, Susanne Petri, Ute Weyen, Patrick Weydt, Johannes Dorst, Albert C Ludolph, Petra Baum, Moritz Oberstadt, Berit Jordan, Andreas Hermann, Joachim Wolf, Matthias Boentert, Bertram Walter, Nadine Gajewski, André Maier, Christoph Münch, Thomas Meyer
OBJECTIVE: The procurement of assistive technology devices (ATD) is an essential component of managed care in ALS. The objective was to analyze the standards of care for ATD and to identify challenges in the provision process. METHODS: A cohort study design was used. We investigated the provision of 11,364 ATD in 1494 patients with ALS at 12 ALS centers in Germany over four years. Participants were patients that entered a case management program for ATD including systematic assessment of ATD on a digital management platform...
January 30, 2018: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
https://www.readbyqxmd.com/read/29368456/rates-of-sustained-virological-response-12%C3%A2-weeks-after-the-scheduled-end-of-direct-acting-antiviral-daa-based-hepatitis-c-virus-hcv-therapy-from-the-national-german-hcv-registry-does-hiv-coinfection-impair-the-response-to-daa-combination-therapy
#16
J Bischoff, S Mauss, C Cordes, T Lutz, S Scholten, A Moll, H Jäger, M Cornberg, M P Manns, A Baumgarten, J K Rockstroh
OBJECTIVES: The European Association for the Study of the Liver (EASL) treatment recommendations for hepatitis C no longer discriminate between HIV/hepatitis C virus (HCV)-coinfected and HCV-monoinfected patients. However, recent data from Spain are questioning these recommendations on the basis of the findings of higher relapse rates and lower cure rates in HIV/HCV-infected subjects. The aim of our study was to compare HCV cure rates in monoinfected and coinfected patients from Germany...
January 25, 2018: HIV Medicine
https://www.readbyqxmd.com/read/29364885/does-a-narcissism-epidemic-exist-in-modern-western-societies-comparing-narcissism-and-self-esteem-in-east-and-west-germany
#17
COMPARATIVE STUDY
Aline Vater, Steffen Moritz, Stefan Roepke
Narcissism scores are higher in individualistic cultures compared with more collectivistic cultures. However, the impact of sociocultural factors on narcissism and self-esteem has not been well described. Germany was formerly divided into two different social systems, each with distinct economic, political and national cultures, and was reunified in 1989/90. Between 1949 and 1989/90, West Germany had an individualistic culture, whereas East Germany had a more collectivistic culture. The German reunification provides an exceptional opportunity to investigate the impact of sociocultural and generational differences on narcissism and self-esteem...
2018: PloS One
https://www.readbyqxmd.com/read/29363389/real-world-analysis-of-dispensed-ius-of-coagulation-factor-ix-and-resultant-expenditures-in-hemophilia-b-patients-receiving-standard-half-life-versus-extended-half-life-products-and-those-switching-from-standard-half-life-to-extended-half-life-products
#18
Bartholomew J Tortella, José Alvir, Margaret McDonald, Dean Spurden, Patrick F Fogarty, Amit Chhabra, Andreas M Pleil
BACKGROUND: Hemophilia B requires replacement therapy with factor IX (FIX) coagulation products to treat and prevent bleeding episodes. A recently introduced extended half-life (EHL) recombinant FIX replacement product provided the opportunity to compare the amount of dispensed factor and expenditures for EHL treatment compared with a standard half-life (SHL) product. OBJECTIVE: To determine factor international units (IUs) dispensed and expenditures associated with switching from nonacog alfa, the most commonly used SHL replacement product, to eftrenonacog alfa, an EHL FIX replacement product...
January 24, 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29331601/predictors-of-length-of-stay-in-psychiatric-inpatient-units-does-their-effect-vary-across-countries
#19
Giorgia Dimitri, Domenico Giacco, Michael Bauer, Victoria Jane Bird, Lauren Greenberg, Antonio Lasalvia, Vincent Lorant, Jacek Moskalewicz, Pablo Nicaise, Andrea Pfennig, Mirella Ruggeri, Marta Welbel, Stefan Priebe
BACKGROUND: Previous studies in individual countries have identified inconsistent predictors of length of stay (LoS) in psychiatric inpatient units. This may reflect methodological inconsistencies across studies or true differences of predictors. In this study we assessed predictors of LoS in five European countries and explored whether their effect varies across countries. METHODS: Prospective cohort study. All patients admitted over 14 months to 57 psychiatric inpatient units in Belgium, Germany, Italy, Poland and United Kingdom were screened...
February 2018: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29318691/trends-in-alcohol-related-mortality-in-east-and-west-germany-1980-2014-age-period-and-cohort-variations
#20
Daniela Piontek, Ludwig Kraus
BACKGROUND AND AIMS: Several indicators suggest that the extent and trends of alcohol-related mortality differ between East and West Germany. Regional drinking patterns and differences in health-care systems are assumed to affect the risk of dying from an alcohol-induced disease. The study addresses two questions: (1) what are the unbiased and independent age, period and cohort effects on alcohol-related mortality trends in Germany; and (2) do these trends differ between East and West Germany? METHODS: Data on alcohol-related mortality for East and West Germany came from the national causes of death register for the years 1980-2014...
May 2018: Addiction
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