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Germany National Cohort

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https://www.readbyqxmd.com/read/29136628/incidence-of-multiple-sclerosis-in-germany-a-cohort-study-applying-different-case-definitions-based-on-claims-data
#1
Niklas Schmedt, Laura Khil, Klaus Berger, Oliver Riedel
BACKGROUND: Data on the incidence of multiple sclerosis (MS) on the national level is scarce. We aimed to estimate the incidence of MS in Germany and to compare different MS case definitions based on claims data. METHODS: We conducted a cohort study with the German Pharmacoepidemiological Research Database in 2012 and calculated age- and gender-standardized incidence rates (sIRs) for 3 case definitions. In addition, the effect of stepwise reduction of the look-back period without MS diagnosis on the incidence rate was evaluated...
November 14, 2017: Neuroepidemiology
https://www.readbyqxmd.com/read/29133244/real-world-effectiveness-of-8-weeks-treatment-with-ledipasvir-sofosbuvir-in-chronic-hepatitis-c
#2
Peter Buggisch, Johannes Vermehren, Stefan Mauss, Rainer Günther, Eckart Schott, Anita Pathil, Klaus Boeker, Tim Zimmermann, Gerlinde Teuber, Heike-Pfeiffer Vornkahl, Karl-Georg Simon, Claus Niederau, Heiner Wedemeyer, Stefan Zeuzem
BACKGROUND AND AIMS: Ledipasvir/Sofosbuvir (LDV/SOF) for 8 to 24 weeks is approved for the treatment of chronic hepatitis C virus infection (HCV). In the ION-3 study 8 weeks of LDV/SOF was non-inferior to 12 weeks in previously untreated genotype 1 (GT1) patients without cirrhosis. According to the summary of product characteristics (SmPC), 8 weeks treatment may be considered in naïve non-cirrhotic GT1-patients. However, there are only limited data on the effectiveness of 8 week regimen of LDV/SOF under real-world conditions available...
November 10, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/29127498/dynamics-in-prevalence-of-down-syndrome-in-children-with-congenital-heart-disease
#3
Constanze Pfitzer, Paul C Helm, Lisa-Maria Rosenthal, Felix Berger, Ulrike M M Bauer, Katharina Rl Schmitt
We assessed the dynamics in the prevalence of children with congenital heart disease (CHD) and Down syndrome in Germany with regard to phenotype, severity, and gender. Data from patients with CHD and Down syndrome born between 1980 and 2014 were analyzed, who are registered with the German National Register for Congenital Heart Defects. One thousand six hundred eighteen CHD patients with Down syndrome were identified. The prevalence of children born with both Down syndrome and CHD was constant from 2005 to 2009 but increased from 2010 to 2014...
November 10, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29046716/a-multi-national-comparison-of-antipsychotic-drug-use-in-children-and-adolescents-2005-2012
#4
Luuk J Kalverdijk, Christian J Bachmann, Lise Aagaard, Mehmet Burcu, Gerd Glaeske, Falk Hoffmann, Irene Petersen, Catharina C M Schuiling-Veninga, Linda P Wijlaars, Julie M Zito
Over the last decades, an increase in antipsychotic (AP) prescribing and a shift from first-generation antipsychotics (FGA) to second-generation antipsychotics (SGA) among youth have been reported. However, most AP prescriptions for youth are off-label, and there are worrying long-term safety data in youth. The objective of this study was to assess multinational trends in AP use among children and adolescents. A repeated cross-sectional design was applied to cohorts from varied sources from Denmark, Germany, the Netherlands, the United Kingdom (UK) and the United States (US) for calendar years 2005/2006-2012...
2017: Child and Adolescent Psychiatry and Mental Health
https://www.readbyqxmd.com/read/28993421/burden-of-mortality-attributable-to-diagnosed-diabetes-a-nationwide-analysis-based-on-claims-data-from-65-million-people-in-germany
#5
Esther Jacobs, Annika Hoyer, Ralph Brinks, Oliver Kuss, Wolfgang Rathmann
OBJECTIVE: In Germany, as in many other countries, nationwide data on mortality attributable to diagnosed diabetes are not available. This study estimated the absolute number of excess deaths associated with diabetes (all types) and type 2 diabetes in Germany. RESEARCH DESIGN AND METHODS: A prevalence approach that included nationwide routine data from 64.9 million people insured in the German statutory health insurance system in 2010 was used for the calculation...
October 9, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28944650/acute-and-overuse-injuries-in-elite-archers
#6
Claudia K Niestroj, Volker Schöffl, Thomas Küpper
BACKGROUND: To evaluate type and incidence of acute and overuse injuries in high level European and German competitive archers. METHODS: Participants of the German National Indoor Championship (DM) 2012 in Solingen, Germany, and European Outdoor Championship (EM) 2012 in Amsterdam, The Netherlands, participated in the study. The design was a retrospective cohort study performed by a questionnaire. Data obtained included standard personal data (age, gender), training habits, draw weight, competition experience, and detailed data about acute and overuse injuries that occurred during the entire sporting career of the archers...
September 22, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28942086/validation-of-a-52-gene-risk-profile-for-outcome-prediction-in-patients-with-idiopathic-pulmonary-fibrosis-an-international-multicentre-cohort-study
#7
Jose D Herazo-Maya, Jiehuan Sun, Philip L Molyneaux, Qin Li, Julian A Villalba, Argyrios Tzouvelekis, Heather Lynn, Brenda M Juan-Guardela, Cristobal Risquez, Juan C Osorio, Xiting Yan, George Michel, Nachelle Aurelien, Kathleen O Lindell, Melinda J Klesen, Miriam F Moffatt, William O Cookson, Yingze Zhang, Joe G N Garcia, Imre Noth, Antje Prasse, Ziv Bar-Joseph, Kevin F Gibson, Hongyu Zhao, Erica L Herzog, Ivan O Rosas, Toby M Maher, Naftali Kaminski
BACKGROUND: The clinical course of idiopathic pulmonary fibrosis (IPF) is unpredictable. Clinical prediction tools are not accurate enough to predict disease outcomes. METHODS: We enrolled patients with IPF diagnosis in a six-cohort study at Yale University (New Haven, CT, USA), Imperial College London (London, UK), University of Chicago (Chicago, IL, USA), University of Pittsburgh (Pittsburgh, PA, USA), University of Freiburg (Freiburg im Breisgau, Germany), and Brigham and Women's Hospital-Harvard Medical School (Boston, MA, USA)...
November 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28815360/epidemiology-in-germany-general-development-and-personal-experience
#8
Heinz-Erich Wichmann
Did you ever hear about epidemiology in Germany? Starting from an epidemiological desert the discipline has grown remarkably, especially during the last 10-15 years: research institutes have been established, research funding has improved, multiple curriculae in Epidemiology and Public Health are offered. This increase has been quite steep, and now the epidemiological infrastructure is much better. Several medium-sized and even big population cohorts are ongoing, and the number and quality of publications from German epidemiologists has reached a respectable level...
August 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28789656/the-national-eye-institute-25-item-visual-function-questionnaire-nei-vfq-25-reference-data-from-the-german-population-based-gutenberg-health-study-ghs
#9
Stefan Nickels, Alexander K Schuster, Susanne Singer, Philipp S Wild, Dagmar Laubert-Reh, Andreas Schulz, Robert P Finger, Matthias Michal, Manfred E Beutel, Thomas Münzel, Karl J Lackner, Norbert Pfeiffer
BACKGROUND: To estimate the burden of diseases, it is important to consider patient-reported outcomes including Quality of Life (QoL). The aim of this study is to provide population-based reference data for the National Eye Institute 25-Item Visual Function Questionnaire (NEI VFQ-25), stratified by sex and age. METHODS: The Gutenberg Health Study (GHS) is a population-based, prospective, observational cohort study in Germany, including 15,010 participants aged between 35 and 74...
August 8, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28783240/social-media-use-in-german-visceral-surgeons-a-cross-sectional-study-of-a-national-cohort
#10
C M Boßelmann, B Griffiths, H J Gallagher, K E Matzel, R R W Brady
BACKGROUND: Engagement in social media is increasing. Medical professionals have been adapting LinkedIn, a professional networking site, and Twitter, a micro-blogging service, for a number of uses. This development has been described for a number of medical specialties, but there remains a paucity of European data. A study was undertaken to measure engagement and activity of German visceral surgeons on social media platforms. METHOD: Visceral surgeons were identified from 15 regional Associations of Statutory Health Insurance Physicians (Kassenärztliche Vereinigungen) opt-in registers...
August 7, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28746388/the-role-of-personality-in-health-care-use-results-of-a-population-based-longitudinal-study-in-germany
#11
André Hajek, Jens-Oliver Bock, Hans-Helmut König
OBJECTIVE: To determine the role of personality in health care use longitudinally. METHODS: Data were derived from the German Socio-Economic Panel (GSOEP), a nationally representative, longitudinal cohort study of German households starting in 1984. Concentrating on the role of personality, we used data from the years 2005, 2009 and 2013. Personality was measured by using the GSOEP Big Five Inventory (BFI-S). Number of physician visits in the last 3 months and hospital stays in the last year were used as measures of health care use...
2017: PloS One
https://www.readbyqxmd.com/read/28714705/professional-psychology-in-germany-national-socialism-and-the-second-world-war
#12
Wolfgang Schönpflug
Hundreds of positions for psychologists were established after the National Socialists seized power in 1933. It has accordingly been asserted that professional psychology in Germany experienced significant growth during the National Socialist period. An analysis of archival materials and of a recent collection of biographies indicates otherwise, however. German psychology, in fact, declined because of systematic persecution and a surge of emigration, a deficit that subsequent cohorts were barely able to make up until 1945...
July 17, 2017: History of Psychology
https://www.readbyqxmd.com/read/28708896/characteristics-and-outcomes-of-a-cohort-hospitalized-for-pandemic-and-seasonal-influenza-in-germany-based-on-nationwide-inpatient-data
#13
Daniel von der Beck, Werner Seeger, Susanne Herold, Andreas Günther, Benjamin Löh
RATIONALE: From June of 2009 to August of 2010 the influenza subtype H1N1pdm09 caused a worldwide pandemic. The impact on populations and health care systems around the globe evolved differently. Substantial data come from the German national surveillance network in an outpatient and private practice setting, while information on hospitalized patients in Germany is rather limited. METHODS: Data from the Federal Statistics Office comprising health insurance claims of the entire nationwide inpatient sample from 2005 to 2012 were used to identify patients who were hospitalized for laboratory-confirmed influenza and to analyse demographical aspects, comorbidities, hospitalization duration, outcomes and ventilator use during the pandemic and seasonal waves of influenza...
2017: PloS One
https://www.readbyqxmd.com/read/28702880/atrial-fibrillation-in-immigrant-groups-a-cohort-study-of-all-adults-45%C3%A2-years-of-age-and-older-in-sweden
#14
Per Wändell, Axel C Carlsson, Xinjun Li, Danijela Gasevic, Johan Ärnlöv, Martin J Holzmann, Jan Sundquist, Kristina Sundquist
To study the association between country of birth and incident atrial fibrillation (AF) in several immigrant groups in Sweden. The study population included all adults (n = 3,226,752) aged 45 years and older in Sweden. AF was defined as having at least one registered diagnosis of AF in the National Patient Register. The incidence of AF in different immigrant groups, using Swedish-born as referents, was assessed by Cox regression, expressed in hazard ratios (HRs) and 95% confidence intervals (CI). All models were stratified by sex and adjusted for age, geographical residence in Sweden, educational level, marital status, and neighbourhood socioeconomic status...
September 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28662327/mumps-in-the-eastern-bohemia-region-of-the-czech-republic-a-serological-survey-2008-2012
#15
Miroslav Fajfr, Vlasta Štěpánová, Jana Fajfrová
BACKGROUND: The incidence of mumps has decreased in many countries since the introduction of vaccination programmes, however, in the past decade a rapid increase in the disease occurrence has been reported worldwide. The reason for this situation is still not clear. We present the results of a serological survey carried out in the Eastern Bohemia Region of the Czech Republic during the years 2008-2012. METHODS: In total, 2,536 samples of 2,034 patients were examined during the study period...
June 2017: Central European Journal of Public Health
https://www.readbyqxmd.com/read/28624389/plasma-proteome-analysis-in-patients-with-pulmonary-arterial-hypertension-an-observational-cohort-study
#16
Christopher J Rhodes, John Wharton, Pavandeep Ghataorhe, Geoffrey Watson, Barbara Girerd, Luke S Howard, J Simon R Gibbs, Robin Condliffe, Charles A Elliot, David G Kiely, Gerald Simonneau, David Montani, Olivier Sitbon, Henning Gall, Ralph T Schermuly, H Ardeschir Ghofrani, Allan Lawrie, Marc Humbert, Martin R Wilkins
BACKGROUND: Idiopathic and heritable pulmonary arterial hypertension form a rare but molecularly heterogeneous disease group. We aimed to measure and validate differences in plasma concentrations of proteins that are associated with survival in patients with idiopathic or heritable pulmonary arterial hypertension to improve risk stratification. METHODS: In this observational cohort study, we enrolled patients with idiopathic or heritable pulmonary arterial hypertension from London (UK; cohorts 1 and 2), Giessen (Germany; cohort 3), and Paris (France; cohort 4)...
September 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28587625/anti-nuclear-autoantibodies-in-the-general-german-population-prevalence-and-lack-of-association-with-selected-cardiovascular-and-metabolic-disorders-findings-of-a-multicenter-population-based-study
#17
Manas K Akmatov, Nadja Röber, Wolfgang Ahrens, Dieter Flesch-Janys, Julia Fricke, Halina Greiser, Kathrin Günther, Rudolf Kaaks, Yvonne Kemmling, Bastian Krone, Jakob Linseisen, Christa Meisinger, Susanne Moebus, Nadia Obi, Carlos A Guzman, Karsten Conrad, Frank Pessler
BACKGROUND: We determined the prevalence of anti-nuclear autoantibodies (ANAs) in the German adult population and examined the association between ANAs and cardiovascular and metabolic disorders. METHODS: We used data and blood samples from the pretest phases of the German National Cohort, obtained from six of the 18 study centers (n = 1199). All centers applied standardized instruments including face-to-face interviews, anthropometric measurements and collection of blood samples...
June 6, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28545785/somatization-among-persons-with-turkish-origin-results-of-the-pretest-of-the-german-national-cohort-study
#18
Eva Morawa, Nico Dragano, Karl-Heinz Jöckel, Susanne Moebus, Tilman Brand, Yesim Erim
OBJECTIVE: Despite the emerging need to examine mental health of immigrants, there are no investigations designed to analyze representative samples in Germany. The aim of the present study was to explore the severity of somatic symptoms/somatization among a sample of considerable size consisting of persons with Turkish origin. We studied whether somatization was associated with sociodemographic and migration-related characteristics. METHODS: This examination was part of a pretest for a large national epidemiological cohort study in Germany...
May 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28477091/prevalence-of-hearing-loss-in-northern-and-southern-germany
#19
P von Gablenz, E Hoffmann, I Holube
BACKGROUND: The HÖRSTAT study conducted in Northwest Germany found hearing impairment in approximately 16% of adults when applying the World Health Organization (WHO) criterion. However, the robustness of extrapolations to a national level might be questioned, as the epidemiological data were collected on a regional level. METHODS: Independently from HÖRSTAT, the "Hearing in Germany" study examined adult hearing in Aalen, a town located in Southwest Germany...
May 5, 2017: HNO
https://www.readbyqxmd.com/read/28467489/longitudinal-change-in-health-related-quality-of-life-in-people-with-prevalent-and-incident-type-2-diabetes-compared-to-diabetes-free-controls
#20
Michaela Schunk, Peter Reitmeir, Ina-Maria Rückert-Eheberg, Teresa Tamayo, Sabine Schipf, Christa Meisinger, Annette Peters, Christa Scheidt-Nave, Ute Ellert, Saskia Hartwig, Alexander Kluttig, Henry Völzke, Rolf Holle
OBJECTIVE: The objective of this analysis is to compare people with prevalent type 2 diabetes, incident type 2 diabetes and without diabetes with respect to longitudinal change in health-related quality of life (HRQOL) when adjusting for baseline determinants of HRQOL. RESEARCH DESIGN AND METHODS: Primary baseline and follow-up data from three regional and one national population-based cohort studies in Germany were pooled for analysis. HRQOL was measured using physical and mental health summary scores (PCS and MCS) from the German version of the Short Form Health Survey with 36 or 12 items...
2017: PloS One
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