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Germany National Cohort

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https://www.readbyqxmd.com/read/28289789/-medical-care-of-patients-with-spasticity-following-stroke-evaluation-of-the-treatment-situation-in-germany-with-focus-on-the-use-of-botulinum-toxin
#1
L Kerkemeyer, G Lux, A Walendzik, J Wasem, A Neumann
BACKGROUND: Upper limb spasticity is a common complication following stroke. Cohort studies found 19% of post-stroke patients had upper limb spasticity at 3 months and 38% of patients at 12 months. For focal spasticity, intramuscular injections of botulinum toxin are indicated. In Germany, it is assumed that patients with the described indication are undersupplied with botulinum toxin. OBJECTIVE: The aim of the present study is to evaluate the medical care of patients with upper limb spasticity post-stroke with the focus on the use of botulinum toxin as one treatment option...
March 13, 2017: Der Nervenarzt
https://www.readbyqxmd.com/read/28271167/-prevalence-of-hearing-loss-in-northern-and-southern-germany-german-version
#2
P von Gablenz, E Hoffmann, I Holube
BACKGROUND: The HÖRSTAT study conducted in Northwest Germany yielded hearing impairment in approximately 16% of adults according to the World Health Organization (WHO) criterion. However, the robustness of extrapolations on a national level might be questioned, as the epidemiological data were collected on a regional level. METHODS: Independently from HÖRSTAT, the "Hearing in Germany" study examined adult hearing in Aalen, a town located in Southwest Germany...
March 7, 2017: HNO
https://www.readbyqxmd.com/read/28255647/acculturation-and-health-related-quality-of-life-results-from-the-german-national-cohort-migrant-feasibility-study
#3
Tilman Brand, Florence Samkange-Zeeb, Ute Ellert, Thomas Keil, Lilian Krist, Nico Dragano, Karl-Heinz Jöckel, Oliver Razum, Katharina Reiss, Karin Halina Greiser, Heiko Zimmermann, Heiko Becher, Hajo Zeeb
OBJECTIVES: We assessed the association between acculturation and health-related quality of life (HRQoL) among persons with a Turkish migrant background in Germany. METHODS: 1226 adults of Turkish origin were recruited in four German cities. Acculturation was assessed using the Frankfurt Acculturation Scale resulting in four groups (integration, assimilation, separation and marginalization). Short Form-8 physical and mental components were used to assess the HRQoL...
March 2, 2017: International Journal of Public Health
https://www.readbyqxmd.com/read/28220197/prevalence-of-sarcopenia-and-sarcopenic-obesity-in-older-german-men-using-recognized-definitions-high-accordance-but-low-overlap
#4
W Kemmler, M Teschler, A Weißenfels, C Sieber, E Freiberger, S von Stengel
The relevance of sarcopenia and sarcopenic Obesity (SO) is rising in our aging societies. Applying recognized definitions to 965 community-dwelling Bavarian men 70 years+ resulted in a prevalence for sarcopenia between 3.7 and 4.9 and between 2.1 and 4.1% for SO. Despite this high consistency, the overlap between the definitions/approaches was <50%. INTRODUCTION: The relevance of sarcopenia and sarcopenic obesity (SO) is rising steadily in the aging societies of most developed nations...
February 20, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28209331/treatment-effectiveness-of-alemtuzumab-compared-with-natalizumab-fingolimod-and-interferon-beta-in-relapsing-remitting-multiple-sclerosis-a-cohort-study
#5
Tomas Kalincik, J William L Brown, Neil Robertson, Mark Willis, Neil Scolding, Claire M Rice, Alastair Wilkins, Owen Pearson, Tjalf Ziemssen, Michael Hutchinson, Christopher McGuigan, Vilija Jokubaitis, Tim Spelman, Dana Horakova, Eva Havrdova, Maria Trojano, Guillermo Izquierdo, Alessandra Lugaresi, Alexandre Prat, Marc Girard, Pierre Duquette, Pierre Grammond, Raed Alroughani, Eugenio Pucci, Patrizia Sola, Raymond Hupperts, Jeannette Lechner-Scott, Murat Terzi, Vincent Van Pesch, Csilla Rozsa, François Grand'Maison, Cavit Boz, Franco Granella, Mark Slee, Daniele Spitaleri, Javier Olascoaga, Roberto Bergamaschi, Freek Verheul, Steve Vucic, Pamela McCombe, Suzanne Hodgkinson, Jose Luis Sanchez-Menoyo, Radek Ampapa, Magdolna Simo, Tunde Csepany, Cristina Ramo, Edgardo Cristiano, Michael Barnett, Helmut Butzkueven, Alasdair Coles
BACKGROUND: Alemtuzumab, an anti-CD52 antibody, is proven to be more efficacious than interferon beta-1a in the treatment of relapsing-remitting multiple sclerosis, but its efficacy relative to more potent immunotherapies is unknown. We compared the effectiveness of alemtuzumab with natalizumab, fingolimod, and interferon beta in patients with relapsing-remitting multiple sclerosis treated for up to 5 years. METHODS: In this international cohort study, we used data from propensity-matched patients with relapsing-remitting multiple sclerosis from the MSBase and six other cohorts...
February 10, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28174294/trastuzumab-in-human-epidermal-growth-factor-receptor-2-positive-early-breast-cancer-results-of-a-prospective-noninterventional-study-on-routine-treatment-between-2006-and-2012-in-germany
#6
Peter Dall, Thorsten Koch, Thomas Göhler, Johannes Selbach, Andreas Ammon, Jochen Eggert, Nidal Gazawi, Daniela Rezek, Arthur Wischnik, Carsten Hielscher, Stella Keitel, Ursula Cirrincione, Axel Hinke, Gabriele Feisel-Schwickardi
PURPOSE: Trastuzumab is part of the standard treatment in patients with human epidermal growth factor receptor 2-positive early breast cancer in addition to (neo)adjuvant chemotherapy. This German prospective noninterventional study, which included major patient cohorts underrepresented in the pivotal randomized studies, examined the generalizability of the results of those studies. PATIENTS AND METHODS: Between 2006 and 2012, 4,027 patients were enrolled and treated with trastuzumab; they were unselected regarding age or concomitant/sequential adjuvant chemotherapy...
February 7, 2017: Oncologist
https://www.readbyqxmd.com/read/28133890/characterization-of-new-users-of-cilostazol-in-the-uk-spain-sweden-and-germany
#7
Jordi Castellsague, Susana Perez-Gutthann, Brian Calingaert, Christine Bui, Cristina Varas-Lorenzo, Alejandro Arana, Alexandra Prados-Torres, Beatriz Poblador-Plou, Francisca Gonzalez-Rubio, Maria Giner-Soriano, Albert Roso-Llorach, Marie Linder, Anna Citarella, Oliver Scholle, Tilo Blenk, Edeltraut Garbe
PURPOSE: To describe the characteristics of new users of cilostazol in Europe with the aim to support the evaluation of its benefit/risk as used in regular clinical practice before the implementation of labeling changes recommended by the European Medicines Agency. METHODS: New users of cilostazol were identified in populations enrolled in five European health automated databases in the UK (The Health Improvement Network [THIN]), Spain (EpiChron cohort and Information System for the Improvement of Research in Primary Care [SIDIAP]), Sweden (National Registers), and Germany (German Pharmacoepidemiological Research Database [GePaRD]) between 2002 and 2012...
January 30, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28012694/antibiotic-use-in-children-a-cross-national-analysis-of-6-countries
#8
Ilan Youngster, Jerry Avorn, Valeria Belleudi, Anna Cantarutti, Javier Díez-Domingo, Ursula Kirchmayer, Byung-Joo Park, Salvador Peiró, Gabriel Sanfélix-Gimeno, Helmut Schröder, Katrin Schüssel, Ju-Young Shin, Sun Mi Shin, Gunnar Skov Simonsen, Hege Salvesen Blix, Angela Tong, Gianluca Trifirò, Tomer Ziv-Baran, Seoyoung C Kim
OBJECTIVES: To describe the rates of pediatric antibiotic use across 6 countries on 3 continents. STUDY DESIGN: Cross-national analysis of 7 pediatric cohorts in 6 countries (Germany, Italy, South Korea, Norway, Spain, and the US) was performed for 2008-2012. Antibiotic dispensings were identified and grouped into subclasses. We calculated the rates of antimicrobial prescriptions per person-year specific to each age group, comparing the rates across different countries...
March 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/27846042/the-incidence-of-hypertension-and-its-risk-factors-in-the-german-adult-population-results-from-the-german-national-health-interview-and-examination-survey-1998-and-the-german-health-interview-and-examination-survey-for-adults-2008-2011
#9
Claudia Diederichs, Hannelore Neuhauser
OBJECTIVE: To analyze incident hypertension and its risk factors based on 11.9 years follow-up of a recent National Examination Survey cohort in Germany. METHODS: Out of 7124 participants of the German National Health Interview and Examination Survey 1998 (GNHIES98), 640 had died at follow-up 2008-2011 and 3045 were reexamined as part of the German Health Interview and Examination Survey for Adults 2008-2011 (DEGS1). Baseline and follow-up included standardized blood pressure (BP) measurements...
February 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/27807198/doxycycline-in-early-cjd-a-double-blinded-randomised-phase-ii-and-observational-study
#10
Daniela Varges, Henrike Manthey, Uta Heinemann, Claudia Ponto, Matthias Schmitz, Walter J Schulz-Schaeffer, Anna Krasnianski, Maren Breithaupt, Fabian Fincke, Katharina Kramer, Tim Friede, Inga Zerr
OBJECTIVES: The main objective of the present study is to study the therapeutic efficiency of doxycycline in a double-blinded randomised phase II study in a cohort of patients with sporadic Creutzfeldt-Jakob disease (sCJD). METHODS: From the National Reference Center of TSE Surveillance in Germany, patients with probable or definite sCJD were recruited for a double-blinded randomised study with oral doxycycline (EudraCT 2006-003934-14). In addition, we analysed the data from patients with CJD who received compassionate treatment with doxycycline in a separate group...
February 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/27624575/cardiac-safety-profile-of-first-dose-of-fingolimod-for-relapsing-remitting-multiple-sclerosis-in-real-world-settings-data-from-a-german-prospective-multi-center-observational-study
#11
Ralf A Linker, Guillaume Wendt
INTRODUCTION: Fingolimod was the first oral therapy approved for the treatment of relapsing-remitting multiple sclerosis (RRMS). Due to its action on cardiac sphingosine 1-phosphate receptors, fingolimod is leading to a transient decrease in heart rate (HR) and the occurrence of rare and asymptomatic self-limited atrioventricular (AV) blocks. This German non-interventional clinical study aimed to assess the cardiac safety profile in RRMS patients during at least 6 h after the initial treatment or restart after interruption of fingolimod in real-world settings...
December 2016: Neurology and Therapy
https://www.readbyqxmd.com/read/27586138/chess-databases-as-a-research-vehicle-in-psychology-modeling-large-data
#12
Nemanja Vaci, Merim Bilalić
The game of chess has often been used for psychological investigations, particularly in cognitive science. The clear-cut rules and well-defined environment of chess provide a model for investigations of basic cognitive processes, such as perception, memory, and problem solving, while the precise rating system for the measurement of skill has enabled investigations of individual differences and expertise-related effects. In the present study, we focus on another appealing feature of chess-namely, the large archive databases associated with the game...
September 1, 2016: Behavior Research Methods
https://www.readbyqxmd.com/read/27535544/progress-prospective-observational-study-on-hospitalized-community-acquired-pneumonia
#13
Peter Ahnert, Petra Creutz, Markus Scholz, Hartwig Schütte, Christoph Engel, Hamid Hossain, Trinad Chakraborty, Michael Bauer, Michael Kiehntopf, Uwe Völker, Sven Hammerschmidt, Markus Loeffler, Norbert Suttorp
BACKGROUND: Community acquired pneumonia (CAP) is a high incidence disease resulting in about 260,000 hospital admissions per year in Germany, more than myocardial infarction or stroke. Worldwide, CAP is the most frequent infectious disease with high lethality ranging from 1.2 % in those 20-29 years old to over 10 % in patients older than 70 years, even in industrial nations. CAP poses numerous medical challenges, which the PROGRESS (Pneumonia Research Network on Genetic Resistance and Susceptibility for the Evolution of Severe Sepsis) network aims to tackle: Operationalization of disease severity throughout the course of disease, outcome prediction for hospitalized patients and prediction of transitions from uncomplicated CAP to severe CAP, and finally, to CAP with sepsis and organ failure as a life-threatening condition...
July 28, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27452312/the-100-most-cited-original-articles-in-cardiac-computed-tomography-a-bibliometric-analysis
#14
REVIEW
Michael E O'Keeffe, Tarek N Hanna, Davis Holmes, Olivia Marais, Mohammed F Mohammed, Sheldon Clark, Patrick McLaughlin, Savvas Nicolaou, Faisal Khosa
Bibliometric analysis is the application of statistical methods to analyze quantitative data about scientific publications. It can evaluate research performance, author productivity, and manuscript impact. To the best of our knowledge, no bibliometric analysis has focused on cardiac computed tomography (CT). The purpose of this paper was to compile a list of the 100 most-cited articles related to cardiac CT literature using Scopus and Web of Science (WOS). A list of the 100 most-cited articles was compiled by order of citation frequency, as well a list of the top 10 most-cited guideline and review articles and the 20 most-cited articles of the years 2014-2015...
September 2016: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/27428238/different-survival-outcomes-after-curative-r0-resection-for-eastern-asian-and-european-gastric-cancer-results-from-a-propensity-score-matched-analysis-comparing-a-korean-and-a-german-specialized-center
#15
COMPARATIVE STUDY
Young-Woo Kim, Jungnam Joo, Hong Man Yoon, Bang Wool Eom, Keun Won Ryu, Il Ju Choi, Myeong Cherl Kook, Christoph Schuhmacher, Joerg Ruediger Siewert, Daniel Reim
Several retrospective analyses on patients who underwent gastric cancer (GC) surgery revealed different survival outcomes between Eastern (Korean, Japanese) and Western (USA, Europe) countries due to potential ethnical and biological differences. This study investigates treatment outcomes between specialized institution for GC in Korea and Germany.The prospectively documented databases of the Gastric Cancer Center of the National Cancer Center, Korea (NCCK) and the Department of Surgery of the Technische Universitaet Muenchen (TUM), Germany were screened for patients who underwent primary surgical resection for GC between 2002 and 2008...
July 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27382102/how-eye-preserving-therapy-affects-long-term-overall-survival-in-heritable-retinoblastoma-survivors
#16
Petra Temming, Marina Arendt, Anja Viehmann, Lewin Eisele, Claudia H D Le Guin, Michael M Schündeln, Eva Biewald, Jennifer Mäusert, Regina Wieland, Norbert Bornfeld, Wolfgang Sauerwein, Angelika Eggert, Dietmar R Lohmann, Karl-Heinz Jöckel
PURPOSE: Intraocular retinoblastoma is curable, but survivors with a heritable predisposition are at high risk for second malignancies. Because second malignancies are associated with high mortality, prognostic factors for second malignancy influence long-term overall survival. This study investigates the impact of all types of eye-preserving therapies on long-term survival in the complete German cohort of patients with heritable retinoblastoma. PATIENTS AND METHODS: Overall survival, disease staging using international scales, time period of diagnosis, and treatment type were analyzed in the 633 German children treated at the national reference center for heritable retinoblastoma...
September 10, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27244822/changing-societal-and-lifestyle-factors-and-breastfeeding-patterns-over-time
#17
Chad Logan, Tatjana Zittel, Stefanie Striebel, Frank Reister, Hermann Brenner, Dietrich Rothenbacher, Jon Genuneit
BACKGROUND: Breastfeeding is an important determinant of early infant immune function and potentially future health. Although numerous studies have reported rising breastfeeding initiation rates and duration, few longitudinally investigated the impact of shifting societal and lifestyle factors on breastfeeding patterns in developed nations. METHODS: The Ulm Birth Cohort Study (UBCS) and Ulm SPATZ Health Study (SPATZ) cohorts consist of newborns and their mothers recruited, respectively, from 2000 to 2001 and 2012 to 2013 at the University Medical Center Ulm, Germany...
May 2016: Pediatrics
https://www.readbyqxmd.com/read/27139177/population-based-imaging-and-radiomics-rationale-and-perspective-of-the-german-national-cohort-mri%C3%A2-study
#18
C L Schlett, T Hendel, S Weckbach, M Reiser, H U Kauczor, K Nikolaou, M Günther, M Forsting, N Hosten, H Völzke, F Bamberg
UNLABELLED: The MRI study within the German National Cohort, a large-scale, population-based, longitudinal study in Germany, comprises comprehensive characterization and phenotyping of a total of 30 000 participants using 3-Tesla whole-body MR imaging. A multi-centric study design was established together with dedicated core facilities for e. g. managing incidental findings or providing quality assurance. As such, the study represents a unique opportunity to substantially impact imaging-based risk stratification leading to personalized and precision medicine...
July 2016: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/27113505/the-ckd-outcomes-and-practice-patterns-study-ckdopps-rationale-and-methods
#19
Laura Mariani, Bénédicte Stengel, Christian Combe, Ziad A Massy, Helmut Reichel, Danilo Fliser, Roberto Pecoits-Filho, Antonio A Lopes, Kunihiro Yamagata, Takashi Wada, Michelle M Y Wong, Elodie Speyer, Friedrich K Port, Ronald L Pisoni, Bruce M Robinson
BACKGROUND: Minimizing clinical complications in patients with advanced chronic kidney disease (CKD) and improving the transition to dialysis therapy and transplantation represents a challenge, requiring reliable evidence regarding the effects of CKD care on outcomes. STUDY DESIGN: The CKD Outcomes and Practice Patterns Study (CKDopps) is a new international prospective cohort study designed to describe and evaluate variation in nephrologist-led CKD practices. SETTING & PARTICIPANTS: CKDopps is underway in Brazil, France, Germany, Japan, and the United States...
September 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/27065485/social-disparities-in-maternal-smoking-during-pregnancy-comparison-of-two-birth-cohorts-1996-2002-and-2003-2012-based-on-data-from-the-german-kiggs-study
#20
B Kuntz, T Lampert
Background: Maternal smoking during pregnancy represents a significant developmental risk for the unborn child. This study investigated social differences in maternal smoking behavior during pregnancy in mothers living in Germany. The study focused on maternal age at delivery, social status and migration background. Method: The evaluation of data was based on two surveys carried out as part of the German Health Interview and Examination Survey for Children and Adolescents (KiGGS) carried out in 2003-2006 and in 2009-2012...
March 2016: Geburtshilfe und Frauenheilkunde
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