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https://www.readbyqxmd.com/read/29685081/longitudinal-trajectory-of-vulvovaginal-candidiasis-trichomoniasis-and-bacterial-vaginosis-during-pregnancy-as-well-as-the-impact-on-pregnancy-outcome-a-preliminary-study
#1
Cheng-Yang Hu, Feng-Li Li, Xiao-Guo Hua, Wen-Jiang, Xiu-Jun Zhang
OBJECTIVES: The aims of this study were to describe the course of vulvovaginal candidiasis (VVC), trichomoniasis, and bacterial vaginosis (BV) in pregnancy and to explore the association between these longitudinal changes and pregnancy outcomes. METHODS: A total of 793 pregnant women were enrolled at the first trimester of pregnancy and were followed prospectively twice at the second and third trimester. VVC, trichomoniasis, and BV were evaluated at each trimester of pregnancy...
April 23, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29671516/vaginitis-diagnosis-and-treatment
#2
Heather L Paladine, Urmi A Desai
Vaginitis is defined as any condition with symptoms of abnormal vaginal discharge, odor, irritation, itching, or burning. The most common causes of vaginitis are bacterial vaginosis, vulvovaginal candidiasis, and trichomoniasis. Bacterial vaginosis is implicated in 40% to 50% of cases when a cause is identified, with vulvovaginal candidiasis accounting for 20% to 25% and trichomoniasis for 15% to 20% of cases. Noninfectious causes, including atrophic, irritant, allergic, and inflammatory vaginitis, are less common and account for 5% to 10% of vaginitis cases...
March 1, 2018: American Family Physician
https://www.readbyqxmd.com/read/29656416/women-infected-with-hiv-and-the-impact-of-associated-sexually-transmitted-infections
#3
REVIEW
Somaia Reda, Fernanda Aguiar Gonçalves, Melissa Mello Mazepa, Newton Sérgio de Carvalho
OBJECTIVE: To review the relationship between concomitant sexually transmitted infections in women infected with HIV. METHODS: PubMed and Scopus were searched for articles published in English and Portuguese between January 1, 1994, and December 31, 2015, using relevant keywords, including AIDS, HIV, female genital diseases, and sexually transmitted infections. Articles that associated sexually transmitted infections with HIV-infected women were selected for inclusion...
April 14, 2018: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29648469/the-stimulation-of-the-vaginal-immune-system-with-short-term-administration-of-a-vaginal-gel-containing-fraction-of-propionibacterium-acnes-hyaluronic-acid-and-polycarbophil-is-efficacious-in-vaginal-infections-dependent-on-disorders-in-the-vaginal-ecosystem
#4
Gian Benedetto Melis, Bruno Piras, Maria Francesca Marotto, Manuela Neri, Valentina Corda, Valerio Vallerino, Alessandra Saba, Stefano Lello, Monica Pilloni, Pierina Zedda, Anna Maria Paoletti, Valerio Mais
The vaginal immune system (VIS) is the first defense against antigens recognized as foreign. Substances capable of locally activating the VIS could be a valid strategy to treat vulvo-vaginal infections (VVI), caused by changes in the vaginal ecosystem, such as bacterial vaginosis (BV), vulvo-vaginal candidiasis (CA), and mixed vaginitis (MV). Bacterial lysates, obtained by crushing bacterial cultures, exert immuno-modulatory activities. The parietal fraction from Propionibacterium acnes is a patent of Depofarma (MoglianoVeneto, Italy)...
April 12, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29620787/distribution-of-genital-mollicutes-in-the-vaginal-ecosystem-of-women-with-different-clinical-conditions
#5
Claudio Foschi, Melissa Salvo, Antonietta D'Antuono, Valeria Gaspari, Nicoletta Banzola, Roberto Cevenini, Antonella Marangoni
Ureaplasma urelayticum (UU), Ureaplasma parvum (UP), Mycoplasma hominis (MH) and Mycoplasma genitalium (MG) are the most common Mollicutes of the female genital tract. Although many studies have addressed their possible role in the vaginal ecosystem, many aspects remain to be elucidated. The aim of this study was to evaluate the vaginal presence of ureaplasmas/mycoplasmas in women with different clinical conditions. By means of quantitative PCR assays, the prevalence and load of each Mollicute were assessed in different groups of pre-menopausal women: 'healthy' (n=29), women with bacterial vaginosis (BV) (n=21), patients with Chlamydia trachomatis (CT) infection (n=25) and subjects with vulvo-vaginal candidiasis (VVC) (n=23)...
April 5, 2018: New Microbiologica
https://www.readbyqxmd.com/read/29616193/a-comprehensive-in-silico-analysis-of-regulatory-snps-of-human-clec7a-gene-and-its-validation-as-genotypic-and-phenotypic-disease-marker-in-recurrent-vulvovaginal-infections
#6
Namarta Kalia, Manpreet Kaur, Sujata Sharma, Jatinder Singh
Recurrent Vulvovaginal infections (RVVI) are the commonly reported microbiological syndrome affecting millions of women globally. Various molecules of innate immune system are instrumental in clearance of these microbial pathogens, thus suggested as one of the most important contributing factor in determining the disease outcome. Dendritic cell-associated C-type lectin-1 (Dectin-1) is an important molecule of innate immunity that is primarily known for its role in antifungal defenses. However, role of dectin-1 in recognition of other pathogens is also documented...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29526145/observational-prospective-study-on-lactobacillus-plantarum-p-17630-in-the-prevention-of-vaginal-infections-during-and-after-systemic-antibiotic-therapy-or-in-women-with-recurrent-vaginal-or-genitourinary-infections
#7
Antonio Cianci, Ettore Cicinelli, Vincenzo De Leo, Franca Fruzzetti, Maria Giulia Massaro, Alessandro Bulfoni, Fabio Parazzini, Antonio Perino
We performed a prospective cohort parallel observational study on the use of Lactobacillus plantarum P 17630 in the prevention of vaginal infections. Eligible were women with a diagnosis of bacterial vaginosis (<15 days) and documented history of recurrent vaginal infections; and/or cystitis (<15 days); and/or treatment with antibiotics for bacterial respiratory tract infections during the week before the study entry. Study subjects were prescribed Lactobacillus plantarum P 17630 > 100.000...
March 12, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29463379/peptidomic-analysis-of-female-reproductive-tract-secretion-to-identify-putative-anti-infection-peptides-in-the-female-genital-system-via-nanotechnologies
#8
Lina Yan, Ting Luan, Quan Hua, Yun Gu, Ziyi Fu, Xia Liu, Minghui Li, Chengxin Liu, Ping Li, Xin Zeng
The female genital system infections have high-incidence among various gynecological diseases. The role of endogenous peptides in female reproductive tract secretion has been rarely investigated regarding gynecological infections. To identify gynecological infections associated endogenous peptides, a comparative peptidomic profiling of vaginal secretion from sexually mature and perimenopause women was conducted in this study using nanoflow liquid chromatography-tandem mass spectrometer. A total of 3096 peptide fragments originating from 1364 precursor proteins were identified, 102 of which were discrepantly expressed, which included 60 over-expressed peptides and 42 under-expressed peptides in the sexually mature group compared with the perimenopause group...
January 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/29458690/anti-inflammatory-effect-of-two-lactobacillus-strains-during-infection-with-gardnerella-vaginalis-and-candida-albicans-in-a-hela-cell-culture-model
#9
Carolina M A Santos, Maria Cecília V Pires, Thiago L Leão, Anna Karolina S Silva, Lilian S Miranda, Flaviano S Martins, Aristóbolo M Silva, Jacques R Nicoli
Lactobacilli are the dominant bacteria of the vaginal tract of healthy women and they play a major role in the maintenance of mucosal homeostasis, preventing genital infections, such as bacterial vaginosis (BV) and vulvovaginal candidiasis (VVC). It is now known that one mechanism of this protection is the influence that lactobacilli can exert on host immune responses. In this context, we evaluated two Lactobacillus strains (L. plantarum 59 and L. fermentum 137) for their immunomodulatory properties in response to Gardnerella vaginalis (BV) or Candida albicans (VVC) infections in a HeLa cell infection model...
March 2018: Microbiology
https://www.readbyqxmd.com/read/29354612/probiotics-in-the-prevention-and-treatment-of-postmenopausal-vaginal-infections-review-article
#10
REVIEW
Jun-Mo Kim, Yoo Jin Park
Bacterial vaginosis (BV) and complicated vulvovaginal candidiasis (VVC) are frequently occurring vaginal infections in postmenopausal women, caused by an imbalance in vaginal microflora. Postmenopausal women suffer from decreased ovarian hormones estrogen and progesterone. A normal, healthy vaginal microflora mainly comprises Lactobacillus species (spp.), which act beneficially as a bacterial barrier in the vagina, interfering with uropathogens. During premenopausal period, estrogen promotes vaginal colonization by lactobacilli that metabolizing glycogen and producing lactic acid, and maintains intravaginal health by lowering the intravaginal pH level...
December 2017: Journal of Menopausal Medicine
https://www.readbyqxmd.com/read/29168557/probiotics-for-vulvovaginal-candidiasis-in-non-pregnant-women
#11
REVIEW
Huan Yu Xie, Dan Feng, Dong Mei Wei, Ling Mei, Hui Chen, Xun Wang, Fang Fang
BACKGROUND: Vulvovaginal candidiasis (VVC) is estimated to be the second most common form of infection after bacterial vaginosis. The ability of probiotics in maintaining and recovering the normal vaginal microbiota, and their potential ability to resist Candidas give rise to the concept of using probiotics for the treatment of VVC. OBJECTIVES: To assess the effectiveness and safety of probiotics for the treatment of vulvovaginal candidiasis in non-pregnant women...
November 23, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29158246/self-taken-vaginal-swabs-versus-clinician-taken-for-detection-of-candida-and-bacterial-vaginosis-a-case-control-study-in-primary-care
#12
Pam Barnes, Rute Vieira, Jayne Harwood, Mayur Chauhan
BACKGROUND: Vaginal discharge and vulvitis are common presenting symptoms in general practice. Few studies have specifically looked at the validity of self-taken low vulvovaginal swabs (LVS) for the diagnosis of vulvovaginal candidiasis (VVC) and bacterial vaginosis (BV). AIM: To assess if patient self-taken LVS are a valid alternative to clinician-taken high vaginal swabs (HVS) for the detection of VVC and BV. DESIGN AND SETTING: Case-control study with the patient acting as their own control in an urban sexual health centre in Newcastle upon Tyne, UK...
December 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/28867602/a-phase-3-double-blind-placebo-controlled-study-of-the-effectiveness-and-safety-of-single-oral-doses-of-secnidazole-2-g-for-the-treatment-of-women-with-bacterial-vaginosis
#13
RANDOMIZED CONTROLLED TRIAL
Jane R Schwebke, Franklin G Morgan, William Koltun, Paul Nyirjesy
BACKGROUND: A novel single oral dose granule formulation of secnidazole 2 g, a 5-nitroimidazole with a longer half-life (∼17 hours) than metronidazole (∼8 hours), is being developed to treat bacterial vaginosis. OBJECTIVE: We sought to evaluate the effectiveness and safety of single-dose secnidazole 2 g compared to placebo for the treatment of women with bacterial vaginosis. STUDY DESIGN: In all, 189 women with bacterial vaginosis were randomized 2:1 to receive a single oral dose of secnidazole 2 g (N = 125) or matched placebo (N = 64) at 21 centers in the United States...
December 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28804083/vaginal-infections-in-haitian-immigrant-women-living-in-miami-florida
#14
Julia Seay, Morgan Mandigo, Karina Hew, Erin Kobetz
OBJECTIVE: To characterize vulvovaginal candidiasis (VC), trichomonas vaginalis (TV), and bacterial vaginosis (BV) among Haitian women living in Miami to identify contributing factors to cervical cancer disparity in this population. METHODS: Using a CBPR framework, 246 Haitian women (ages 21-65) were recruited. Self-collected cervical cytology specimens were analyzed for VC, TV, and BV. RESULTS: The proportion of participants with VC, TV, and BV, were 7...
2017: Journal of Health Care for the Poor and Underserved
https://www.readbyqxmd.com/read/28594779/clinical-validation-of-a-test-for-the-diagnosis-of-vaginitis
#15
MULTICENTER STUDY
Charlotte A Gaydos, Sajo Beqaj, Jane R Schwebke, Joel Lebed, Bonnie Smith, Thomas E Davis, Kenneth H Fife, Paul Nyirjesy, Timothy Spurrell, Dorothy Furgerson, Jenell Coleman, Sonia Paradis, Charles K Cooper
OBJECTIVE: Vaginitis may be diagnosed as bacterial vaginosis, vulvovaginal candidiasis, trichomoniasis, or coinfection. A new molecular test assays the vaginal microbiome and organisms that cause three common infections. The objective of the trial was to evaluate the clinical accuracy of the investigational test for vaginal swabs collected by patients (self) or clinicians. The primary and secondary outcomes were to compare the investigational test with reference methods for the three most common causes of vaginitis and compare clinician-collected with self-collected swabs...
July 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28502874/aerobic-vaginitis-no-longer-a-stranger
#16
Gilbert G G Donders, Gert Bellen, Svitrigaile Grinceviciene, Kateryna Ruban, Pedro Vieira-Baptista
Aerobic vaginitis (AV) is the name given in 2002 to a vaginal infectious entity which was not recognized as such before. It is characterized by abnormal (dysbiotic) vaginal microflora containing aerobic, enteric bacteria, variable levels of vaginal inflammation and deficient epithelial maturation. Although AV and bacterial vaginosis (BV) share some characteristics, such as a diminished number or absence of lactobacilli, increased discharge (fishy smelling in BV, while in severe forms of AV, a foul, rather rotten smell may be present) and increased pH (often more pronounced in AV), there are also striking differences between the two...
November 2017: Research in Microbiology
https://www.readbyqxmd.com/read/28499528/vaginitis-beyond-the-basics
#17
REVIEW
Benjie Brown Mills
Vaginal complaints are one of the most common reasons women seek the advice of a health care provider. Uncomplicated infections such as vulvovaginal candidiasis, bacterial vaginosis, or trichomoniasis are easy to diagnose and treat. However, about 8% of patients will have a more complicated course with failure to respond to treatment or rapid recurrence of symptoms. Understanding the need for a methodical, diagnostic approach to help these women with recurrent or refractory cases of vaginal symptoms will aid the clinician achieve successful patient outcomes...
June 2017: Obstetrics and Gynecology Clinics of North America
https://www.readbyqxmd.com/read/28468531/prevalence-of-vaginitis-in-different-age-groups-among-females-in-greece
#18
Argiri Sianou, George Galyfos, Dimitra Moragianni, Stavroula Baka
Patients with vaginitis were classified into four groups: Group A (prepubertal under-aged females); Group B (pubertal under-aged females); Group C (reproductive age adult females); Group D (postmenopausal adult females). All vaginal specimens underwent microscopy, amine testing, Gram staining and culturing. Overall, 163 patients were included (33, 14, 81 and 35 patients, respectively). The most common infection was bacterial vaginosis (BV), followed by Ureaplasma infection, aerobic vaginitis (AV) and candidiasis...
May 4, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28460993/cervical-ectropion-may-be-a-cause-of-desquamative-inflammatory-vaginitis
#19
Leia Mitchell, Michelle King, Heather Brillhart, Andrew Goldstein
Desquamative inflammatory vaginitis is a poorly understood chronic vaginitis with an unknown etiology. Symptoms of desquamative inflammatory vaginitis include copious yellowish discharge, vulvovaginal discomfort, and dyspareunia. Cervical ectropion, the presence of glandular columnar cells on the ectocervix, has not been reported as a cause of desquamative inflammatory vaginitis. Although cervical ectropion can be a normal clinical finding, it has been reported to cause leukorrhea, metrorrhagia, dyspareunia, and vulvovaginal irritation...
September 2017: Sexual Medicine
https://www.readbyqxmd.com/read/28442807/epidemiology-and-clinico-investigative-study-of-organisms-causing-vaginal-discharge
#20
Swetha Venugopal, Kannan Gopalan, Asha Devi, A Kavitha
BACKGROUND: Abnormal vaginal discharge is a common clinical problem in reproductive age group. It is the second most common problem after abnormal uterine bleeding. It is a neglected health problem, most commonly caused due to vulvovaginal candidiasis, trichomoniasis, and bacterial vaginosis (BV). OBJECTIVES: The present study was conducted to determine the prevalence of common organisms causing vaginal discharge and also to know the variety of clinical presentation...
January 2017: Indian Journal of Sexually Transmitted Diseases
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