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JOURNAL ARTICLE
Hans-Christoph Diener, Gerrit M Grosse, Anika Hüsing, Andreas Stang, Nils Kuklik, Marcus Brinkmann, Gabriele D Maurer, Hassan Soda, Carsten Pohlmann, Rüdiger Hilker-Roggendorf, Nikola Popovic, Peter Kraft, Bruno-Marcel Mackert, Christoph C Eschenfelder, Christian Weimar
INTRODUCTION: Factor Xa (FXa) inhibitors are superior to vitamin K antagonists (VKAs) in terms of avoiding hemorrhagic complications. However, no robust data are available to date as to whether this also applies to the early phase after stroke. In this prospective registry study, we aimed to investigate whether anticoagulation with FXa inhibitors in the early phase after acute ischemic stroke or transient ischemic attack (TIA) is associated with a lower risk of major bleeding events compared with VKAs...
April 3, 2024: European Stroke Journal
#2
JOURNAL ARTICLE
Xiaoxue Zhang, Daniel J Yelle, Peter Kitin, Guolin Tong, J Y Zhu
This study conducted a detailed evaluation of the feasibility of producing cellulose microfibrils (CMF) from a kraft-bleached hardwood pulp at high solid contents with and without pretreatments. CMFs produced by planetary ball milling at solid contents 17 and 28% were compared with those from 1 to 5% under the same milling conditions. Fiber pretreatments using a commercial endoglucanase and mechanical refining using a laboratory PFI mill were also applied before ball milling at a solid content of 28%. Two mechanisms of fiber fibrillation were identified from the results obtained: (i) ball and fiber/fibril interactions─the primary mechanism and (ii) interfiber/fibril frictional and tensional interactions─the secondary mechanism...
March 21, 2024: Biomacromolecules
#3
JOURNAL ARTICLE
Patrik Greguletz, Maria Plötz, Carolin Baade-Büttner, Christian G Bien, Katharina Eisenhut, Christian Geis, Robert Handreka, Jaqueline Klausewitz, Peter Körtvelyessy, Stjepana Kovac, Andrea Kraft, Jan Lewerenz, Michael Malter, Michael Nagel, Felix von Podewils, Harald Prüß, Anna Rada, Johanna Rau, Sebastian Rauer, Rosa Rößling, Thomas Seifert-Held, Kai Siebenbrodt, Kurt-Wolfram Sühs, Simone C Tauber, Franziska Thaler, Judith Wagner, Jonathan Wickel, Frank Leypoldt, Heike L Rittner, Claudia Sommer, Carmen Villmann, Kathrin Doppler
Autoantibodies against contactin-associated protein 2 (Caspr2) not only induce limbic autoimmune encephalitis but are also associated with pain conditions. Here, we analyzed clinical data on pain in a large cohort of patients included into the German Network for Research in Autoimmune Encephalitis. Out of 102 patients in our cohort, pain was a frequent symptom (36% of all patients), often severe (63.6% of the patients with pain) and/or even the major symptom (55.6% of the patients with pain). Pain phenotypes differed between patients...
February 22, 2024: Journal of Neurology
#4
JOURNAL ARTICLE
Katie C Coate, Christopher J Ramnanan, Marta Smith, Jason J Winnick, Guillaume Kraft, Jose Irimia-Dominguez, Ben Farmer, E Patrick Donahue, Peter J Roach, Alan D Cherrington, Dale S Edgerton
Glucagon rapidly and profoundly simulates hepatic glucose production (HGP), but for reasons which are unclear, this effect normally wanes after a few hours, despite sustained plasma glucagon levels. This study characterized the time course of glucagon-mediated molecular events and their relevance to metabolic flux in the livers of conscious dogs. Glucagon was either infused into the hepato-portal vein at a 6-fold basal rate in the presence of somatostatin and basal insulin, or it was maintained at a basal level in control studies...
February 7, 2024: American Journal of Physiology. Endocrinology and Metabolism
#5
RANDOMIZED CONTROLLED TRIAL
Tobias Geisler, Timea Keller, Peter Martus, Khouloud Poli, Lina Maria Serna-Higuita, Juergen Schreieck, Meinrad Gawaz, Johannes Tünnerhoff, Paula Bombach, Thomas Nägele, Uwe Klose, Parwez Aidery, Patrick Groga-Bada, Andrea Kraft, Frank Hoffmann, Carsten Hobohm, Katrin Naupold, Ludwig Niehaus, Marc Wolf, Hansjörg Bäzner, Jan Liman, Rolf Wachter, Hubert Kimmig, Werner Jung, Roman Huber, Regina Feurer, Alfred Lindner, Katharina Althaus, Felix J Bode, Gabor C Petzold, Thanh N Nguyen, Brian Mac Grory, Matthew Schrag, Jan C Purrucker, Christine S Zuern, Ulf Ziemann, Sven Poli
Apixaban versus Aspirin for Embolic StrokeIn a trial of 352 patients with embolic stroke of undetermined source, 5 mg of apixaban administered twice daily was compared with 100 mg of aspirin administered once daily for the prevention of recurrent ischemic strokes. At 12 months, 13.6% of patients given apixaban had new ischemic lesions on magnetic resonance imaging compared with 16.0% of patients given aspirin, and the rates of clinically relevant bleeding were also comparable.
January 2024: NEJM Evid
#6
JOURNAL ARTICLE
Monica T Kraft, Christian Coletta, Irene Mikhail, Benjamin T Prince, Rebecca Scherzer, Mariah Eisner, Peter Mustillo
No abstract text is available yet for this article.
February 3, 2024: Journal of Allergy and Clinical Immunology in Practice
#7
JOURNAL ARTICLE
Friederike A Arlt, Ramona Miske, Marie-Luise Machule, Peter Broegger Christensen, Swantje Mindorf, Bianca Teegen, Kathrin Borowski, Maria Buthut, Rosa Rößling, Elisa Sanchez-Sendin, Scott van Hoof, César Cordero-Gómez, Isabel Bünger, Helena Radbruch, Andrea Kraft, Ilya Ayzenberg, Jaqueline Klausewitz, Niels Hansen, Charles Timäus, Peter Körtvelyessy, Thomas Postert, Kirsten Baur-Seack, Constanze Rost, Robert Brunkhorst, Kathrin Doppler, Niklas Haigis, Gerhard Hamann, Albrecht Kunze, Alexandra Stützer, Matthias Maschke, Nico Melzer, Felix Rosenow, Kai Siebenbrodt, Christian Stenør, Martin Dichgans, Marios K Georgakis, Rong Fang, Gabor C Petzold, Michael Görtler, Inga Zerr, Silke Wunderlich, Ivan Mihaljevic, Paul Turko, Marianne Schmidt Ettrup, Emilie Buchholz, Helle Foverskov Rasmussen, Mahoor Nasouti, Ivan Talucci, Hans M Maric, Stefan H Heinemann, Matthias Endres, Lars Komorowski, Harald Prüss
BACKGROUND: Autoantibodies against the potassium voltage-gated channel subfamily A member 2 (KCNA2) have been described in a few cases of neuropsychiatric disorders, but their diagnostic and pathophysiological role is currently unknown, imposing challenges to medical practice. DESIGN / METHODS: We retrospectively collected comprehensive clinical and paraclinical data of 35 patients with KCNA2 IgG autoantibodies detected in cell-based and tissue-based assays. Patients' sera and cerebrospinal fluid (CSF) were used for characterization of the antigen, clinical-serological correlations, and determination of IgG subclasses...
February 1, 2024: Brain, Behavior, and Immunity
#8
JOURNAL ARTICLE
Qiao-Li Wang, Ana Babic, Michael H Rosenthal, Alice A Lee, Yin Zhang, Xuehong Zhang, Mingyang Song, Leandro F M Rezende, Dong Hoon Lee, Leah Biller, Kimmie Ng, Marios Giannakis, Andrew T Chan, Jeffrey A Meyerhardt, Charles S Fuchs, A Heather Eliassen, Brenda M Birmann, Meir J Stampfer, Edward L Giovannucci, Peter Kraft, Jonathan A Nowak, Chen Yuan, Brian M Wolpin
IMPORTANCE: Weight loss is common in primary care. Among individuals with recent weight loss, the rates of cancer during the subsequent 12 months are unclear compared with those without recent weight loss. OBJECTIVE: To determine the rates of subsequent cancer diagnoses over 12 months among health professionals with weight loss during the prior 2 years compared with those without recent weight loss. DESIGN, SETTING, AND PARTICIPANTS: Prospective cohort analysis of females aged 40 years or older from the Nurses' Health Study who were followed up from June 1978 until June 30, 2016, and males aged 40 years or older from the Health Professionals Follow-Up Study who were followed up from January 1988 until January 31, 2016...
January 23, 2024: JAMA
#9
Yon Ho Jee, Florian Thibord, Alicia Dominguez, Corriene Sept, Kristin Boulier, Vidhya Venkateswaran, Yi Ding, Tess Cherlin, Shefali Setia Verma, Valeria Lo Faro, Traci M Bartz, Anne Boland, Jennifer A Brody, Jean-Francois Deleuze, Joseph Emmerich, Marine Germain, Andrew D Johnson, Charles Kooperberg, Pierre-Emmanuel Morange, Nathan Pankratz, Bruce M Psaty, Alexander P Reiner, David M Smadja, Colleen M Sitlani, Pierre Suchon, Weihong Tang, David-Alexandre Trégouët, Sebastian Zöllner, Bogdan Pasaniuc, Scott M Damrauer, Serena Sanna, Harold Snieder, Christopher Kabrhel, Nicholas L Smith, Peter Kraft
Venous thromboembolism (VTE) is a significant contributor to morbidity and mortality, with large disparities in incidence rates between Black and White Americans. Polygenic risk scores (PRSs) limited to variants discovered in genome-wide association studies in European-ancestry samples can identify European-ancestry individuals at high risk of VTE. However, there is limited evidence on whether high-dimensional PRS constructed using more sophisticated methods and more diverse training data can enhance the predictive ability and their utility across diverse populations...
January 10, 2024: medRxiv
#10
JOURNAL ARTICLE
Luke Riddell, Jean-Pierre Lindner, Peter de Peinder, Florian Meirer, Pieter Bruijnincx
To expedite the valorisation of lignin as a sustainable component in materials applications, rapid and generally available analytical methods are essential to overcome the bottleneck of lignin characterisation. Where features of a lignin's chemical structure have previously been found to be predicted by Partial Least Squares (PLS) regression models built on Infrared (IR) data, we now show for the first time that this approach can be extended to prediction of the glass transition temperature (T-g), a key physicochemical property...
January 9, 2024: ChemSusChem
#11
JOURNAL ARTICLE
Al Ozonoff, Naresh Doni Jayavelu, Shanshan Liu, Esther Melamed, Carly E Milliren, Jingjing Qi, Linda N Geng, Grace A McComsey, Charles B Cairns, Lindsey R Baden, Joanna Schaenman, Albert C Shaw, Hady Samaha, Vicki Seyfert-Margolis, Florian Krammer, Lindsey B Rosen, Hanno Steen, Caitlin Syphurs, Ravi Dandekar, Casey P Shannon, Rafick P Sekaly, Lauren I R Ehrlich, David B Corry, Farrah Kheradmand, Mark A Atkinson, Scott C Brakenridge, Nelson I Agudelo Higuita, Jordan P Metcalf, Catherine L Hough, William B Messer, Bali Pulendran, Kari C Nadeau, Mark M Davis, Ana Fernandez Sesma, Viviana Simon, Harm van Bakel, Seunghee Kim-Schulze, David A Hafler, Ofer Levy, Monica Kraft, Chris Bime, Elias K Haddad, Carolyn S Calfee, David J Erle, Charles R Langelier, Walter Eckalbar, Steven E Bosinger, Bjoern Peters, Steven H Kleinstein, Elaine F Reed, Alison D Augustine, Joann Diray-Arce, Holden T Maecker, Matthew C Altman, Ruth R Montgomery, Patrice M Becker, Nadine Rouphael
Post-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed from hospital admission for COVID-19 through one year after discharge. Modeling identified 4 PRO clusters based on reported deficits (minimal, physical, mental/cognitive, and multidomain), supporting heterogenous clinical presentations in PASC, with sub-phenotypes associated with female sex and distinctive comorbidities. During the acute phase of disease, a higher respiratory SARS-CoV-2 viral burden and lower Receptor Binding Domain and Spike antibody titers were associated with both the physical predominant and the multidomain deficit clusters...
January 3, 2024: Nature Communications
#12
JOURNAL ARTICLE
Annette Lien, Leonardo Pestana Legori, Louis Kraft, Peter Wad Sackett, Gabriel Renaud
Ancient DNA is highly degraded, resulting in very short sequences. Reads generated with modern high-throughput sequencing machines are generally longer than ancient DNA molecules, therefore the reads often contain some portion of the sequencing adaptors. It is crucial to remove those adaptors, as they can interfere with downstream analysis. Furthermore, overlapping portions when DNA has been read forward and backward (paired-end) can be merged to correct sequencing errors and improve read quality. Several tools have been developed for adapter trimming and read merging, however, no one has attempted to evaluate their accuracy and evaluate their potential impact on downstream analyses...
2023: Front Bioinform
#13
JOURNAL ARTICLE
Ariane Schmetz, Hermann-Josef Lüdecke, Harald Surowy, Sugirtahn Sivalingam, Ange-Line Bruel, Roseline Caumes, Perrine Charles, Nicolas Chatron, Krystyna Chrzanowska, Marta Codina-Solà, Cindy Colson, Ivon Cuscó, Anne-Sophie Denommé-Pichon, Patrick Edery, Laurence Faivre, Andrew Green, Solveig Heide, Tzung-Chien Hsieh, Alexander Hustinx, Lotte Kleinendorst, Cordula Knopp, Florian Kraft, Peter M Krawitz, Amaia Lasa-Aranzasti, Gaetan Lesca, Vanesa López-González, Julien Maraval, Cyril Mignot, Teresa Neuhann, Christian Netzer, Barbara Oehl-Jaschkowitz, Florence Petit, Christophe Philippe, Renata Posmyk, Audrey Putoux, André Reis, María José Sánchez-Soler, Julia Suh, Tinatin Tkemaladze, Frédéric Tran Mau Them, André Travessa, Laura Trujillano, Irene Valenzuela, Mieke M van Haelst, Georgia Vasileiou, Catherine Vincent-Delorme, Mona Walther, Pablo Verde, Nuria C Bramswig, Dagmar Wieczorek
Coffin-Siris syndrome (CSS) is a rare multisystemic autosomal dominant disorder. Since 2012, alterations in genes of the SWI/SNF complex were identified as the molecular basis of CSS, studying largely pediatric cohorts. Therefore, there is a lack of information on the phenotype in adulthood, particularly on the clinical outcome in adulthood and associated risks. In an international collaborative effort, data from 35 individuals ≥ 18 years with a molecularly ascertained CSS diagnosis (variants in ARID1B, ARID2, SMARCA4, SMARCB1, SMARCC2, SMARCE1, SOX11, BICRA) using a comprehensive questionnaire was collected...
January 2024: Human Genetics
#14
JOURNAL ARTICLE
Lauren C Bresee, Nicole Lamont, Wrechelle Ocampo, Jayna Holroyd-Leduc, Deana Sabuda, Jenine Leal, Bruce Dalton, Jaime Kaufman, Bayan Missaghi, Joseph Kim, Oscar E Larios, Elizabeth Henderson, Maitreyi Raman, Jared R Fletcher, Peter Faris, Scott Kraft, Ye Shen, Thomas Louie, John M Conly
BACKGROUND: Clostridioides difficile infection (CDI) is associated with considerable morbidity and mortality in hospitalized patients, especially among older adults. Probiotics have been evaluated to prevent hospital-acquired (HA) CDI in patients who are receiving systemic antibiotics, but the implementation of timely probiotic administration remains a challenge. We evaluated methods for effective probiotic implementation across a large health region as part of a study to assess the real-world effectiveness of a probiotic to prevent HA-CDI (Prevent CDI-55 +)...
December 11, 2023: BMC Health Services Research
#15
JOURNAL ARTICLE
Jenine Leal, Ye Shen, Peter Faris, Bruce Dalton, Deana Sabuda, Wrechelle Ocampo, Lauren Bresee, Blanda Chow, Jared R Fletcher, Elizabeth Henderson, Jaime Kaufman, Joseph Kim, Maitreyi Raman, Scott Kraft, Nicole C Lamont, Oscar Larios, Bayan Missaghi, Jayna Holroyd-Leduc, Thomas Louie, John Conly
OBJECTIVE: To evaluate the impact of administering probiotics to prevent Clostridioides difficile infection (CDI) among patients receiving therapeutic antibiotics. DESIGN: Stepped-wedge cluster-randomized trial between September 1, 2016, and August 31, 2019. SETTING: This study was conducted in 4 acute-care hospitals across an integrated health region. PATIENTS: Hospitalized patients, aged ≥55 years. METHODS: Patients were given 2 probiotic capsules daily (Bio-K+, Laval, Quebec, Canada), containing 50 billion colony-forming units of Lactobacillus acidophilus CL1285, L...
December 11, 2023: Infection Control and Hospital Epidemiology
#16
JOURNAL ARTICLE
Josefine Metzkes-Ng, Florian-Emanuel Brack, Florian Kroll, Constantin Bernert, Stefan Bock, Elisabeth Bodenstein, Michael Brand, Thomas E Cowan, René Gebhardt, Stefan Hans, Uwe Helbig, Felix Horst, Jeannette Jansen, Stephan D Kraft, Mechthild Krause, Elisabeth Leßmann, Steffen Löck, Jörg Pawelke, Thomas Püschel, Marvin Reimold, Martin Rehwald, Christian Richter, Hans-Peter Schlenvoigt, Ulrich Schramm, Michael Schürer, Joao Seco, Emília Rita Szabó, Marvin E P Umlandt, Karl Zeil, Tim Ziegler, Elke Beyreuther
The recently observed FLASH effect describes the observation of normal tissue protection by ultra-high dose rates (UHDR), or dose delivery in a fraction of a second, at similar tumor-killing efficacy of conventional dose delivery and promises great benefits for radiotherapy patients. Dedicated studies are now necessary to define a robust set of dose application parameters for FLASH radiotherapy and to identify underlying mechanisms. These studies require particle accelerators with variable temporal dose application characteristics for numerous radiation qualities, equipped for preclinical radiobiological research...
November 23, 2023: Scientific Reports
#17
Jeremy P Gygi, Cole Maguire, Ravi K Patel, Pramod Shinde, Anna Konstorum, Casey P Shannon, Leqi Xu, Annmarie Hoch, Naresh Doni Jayavelu, Impacc Network, Elias K Haddad, Elaine F Reed, Monica Kraft, Grace A McComsey, Jordan Metcalf, Al Ozonoff, Denise Esserman, Charles B Cairns, Nadine Rouphael, Steven E Bosinger, Seunghee Kim-Schulze, Florian Krammer, Lindsey B Rosen, Harm van Bakel, Michael Wilson, Walter Eckalbar, Holden Maecker, Charles R Langelier, Hanno Steen, Matthew C Altman, Ruth R Montgomery, Ofer Levy, Esther Melamed, Bali Pulendran, Joann Diray-Arce, Kinga K Smolen, Gabriela K Fragiadakis, Patrice M Becker, Alison D Augustine, Rafick P Sekaly, Lauren I R Ehrlich, Slim Fourati, Bjoern Peters, Steven H Kleinstein, Leying Guan
Hospitalized COVID-19 patients exhibit diverse clinical outcomes, with some individuals diverging over time even though their initial disease severity appears similar. A systematic evaluation of molecular and cellular profiles over the full disease course can link immune programs and their coordination with progression heterogeneity. In this study, we carried out deep immunophenotyping and conducted longitudinal multi-omics modeling integrating ten distinct assays on a total of 1,152 IMPACC participants and identified several immune cascades that were significant drivers of differential clinical outcomes...
November 6, 2023: bioRxiv
#18
JOURNAL ARTICLE
Thibaud Coroller, Berkman Sahiner, Anup Amatya, Alexej Gossmann, Konstantinos Karagiannis, Conor Moloney, Ravi K Samala, Luis Santana-Quintero, Nadia Solovieff, Craig Wang, Laleh Amiri-Kordestani, Qian Cao, Kenny H Cha, Rosane Charlab, Frank H Cross, Tingting Hu, Ruihao Huang, Jeffrey Kraft, Peter Krusche, Yutong Li, Zheng Li, Ilya Mazo, Rahul Paul, Susan Schnakenberg, Paolo Serra, Sean Smith, Chi Song, Fei Su, Mohit Tiwari, Colin Vechery, Xin Xiong, Juan Pablo Zarate, Hao Zhu, Arunava Chakravartty, Qi Liu, David Ohlssen, Nicholas Petrick, Julie A Schneider, Mark Walderhaug, Emmanuel Zuber
In 2020, Novartis Pharmaceuticals Corporation and the U.S. Food and Drug Administration (FDA) started a 4-year scientific collaboration to approach complex new data modalities and advanced analytics. The scientific question was to find novel radio-genomics-based prognostic and predictive factors for HR+/HER2- metastatic breast cancer under a Research Collaboration Agreement. This collaboration has been providing valuable insights to help successfully implement future scientific projects, particularly using artificial intelligence (AI) and machine learning (ML)...
November 15, 2023: Clinical Pharmacology and Therapeutics
#19
JOURNAL ARTICLE
Anqi Wang, Jiayi Shen, Alex A Rodriguez, Edward J Saunders, Fei Chen, Rohini Janivara, Burcu F Darst, Xin Sheng, Yili Xu, Alisha J Chou, Sara Benlloch, Tokhir Dadaev, Mark N Brook, Anna Plym, Ali Sahimi, Thomas J Hoffman, Atushi Takahashi, Koichi Matsuda, Yukihide Momozawa, Masashi Fujita, Triin Laisk, Jéssica Figuerêdo, Kenneth Muir, Shuji Ito, Xiaoxi Liu, Yuji Uchio, Michiaki Kubo, Yoichiro Kamatani, Artitaya Lophatananon, Peggy Wan, Caroline Andrews, Adriana Lori, Parichoy P Choudhury, Johanna Schleutker, Teuvo L J Tammela, Csilla Sipeky, Anssi Auvinen, Graham G Giles, Melissa C Southey, Robert J MacInnis, Cezary Cybulski, Dominika Wokolorczyk, Jan Lubinski, Christopher T Rentsch, Kelly Cho, Benjamin H Mcmahon, David E Neal, Jenny L Donovan, Freddie C Hamdy, Richard M Martin, Borge G Nordestgaard, Sune F Nielsen, Maren Weischer, Stig E Bojesen, Andreas Røder, Hein V Stroomberg, Jyotsna Batra, Suzanne Chambers, Lisa Horvath, Judith A Clements, Wayne Tilly, Gail P Risbridger, Henrik Gronberg, Markus Aly, Robert Szulkin, Martin Eklund, Tobias Nordstrom, Nora Pashayan, Alison M Dunning, Maya Ghoussaini, Ruth C Travis, Tim J Key, Elio Riboli, Jong Y Park, Thomas A Sellers, Hui-Yi Lin, Demetrius Albanes, Stephanie Weinstein, Michael B Cook, Lorelei A Mucci, Edward Giovannucci, Sara Lindstrom, Peter Kraft, David J Hunter, Kathryn L Penney, Constance Turman, Catherine M Tangen, Phyllis J Goodman, Ian M Thompson, Robert J Hamilton, Neil E Fleshner, Antonio Finelli, Marie-Élise Parent, Janet L Stanford, Elaine A Ostrander, Stella Koutros, Laura E Beane Freeman, Meir Stampfer, Alicja Wolk, Niclas Håkansson, Gerald L Andriole, Robert N Hoover, Mitchell J Machiela, Karina Dalsgaard Sørensen, Michael Borre, William J Blot, Wei Zheng, Edward D Yeboah, James E Mensah, Yong-Jie Lu, Hong-Wei Zhang, Ninghan Feng, Xueying Mao, Yudong Wu, Shan-Chao Zhao, Zan Sun, Stephen N Thibodeau, Shannon K McDonnell, Daniel J Schaid, Catharine M L West, Gill Barnett, Christiane Maier, Thomas Schnoeller, Manuel Luedeke, Adam S Kibel, Bettina F Drake, Olivier Cussenot, Geraldine Cancel-Tassin, Florence Menegaux, Thérèse Truong, Yves Akoli Koudou, Esther M John, Eli Marie Grindedal, Lovise Maehle, Kay-Tee Khaw, Sue A Ingles, Mariana C Stern, Ana Vega, Antonio Gómez-Caamaño, Laura Fachal, Barry S Rosenstein, Sarah L Kerns, Harry Ostrer, Manuel R Teixeira, Paula Paulo, Andreia Brandão, Stephen Watya, Alexander Lubwama, Jeannette T Bensen, Ebonee N Butler, James L Mohler, Jack A Taylor, Manolis Kogevinas, Trinidad Dierssen-Sotos, Gemma Castaño-Vinyals, Lisa Cannon-Albright, Craig C Teerlink, Chad D Huff, Patrick Pilie, Yao Yu, Ryan J Bohlender, Jian Gu, Sara S Strom, Luc Multigner, Pascal Blanchet, Laurent Brureau, Radka Kaneva, Chavdar Slavov, Vanio Mitev, Robin J Leach, Hermann Brenner, Xuechen Chen, Bernd Holleczek, Ben Schöttker, Eric A Klein, Ann W Hsing, Rick A Kittles, Adam B Murphy, Christopher J Logothetis, Jeri Kim, Susan L Neuhausen, Linda Steele, Yuan Chun Ding, William B Isaacs, Barbara Nemesure, Anselm J M Hennis, John Carpten, Hardev Pandha, Agnieszka Michael, Kim De Ruyck, Gert De Meerleer, Piet Ost, Jianfeng Xu, Azad Razack, Jasmine Lim, Soo-Hwang Teo, Lisa F Newcomb, Daniel W Lin, Jay H Fowke, Christine M Neslund-Dudas, Benjamin A Rybicki, Marija Gamulin, Davor Lessel, Tomislav Kulis, Nawaid Usmani, Aswin Abraham, Sandeep Singhal, Matthew Parliament, Frank Claessens, Steven Joniau, Thomas Van den Broeck, Manuela Gago-Dominguez, Jose Esteban Castelao, Maria Elena Martinez, Samantha Larkin, Paul A Townsend, Claire Aukim-Hastie, William S Bush, Melinda C Aldrich, Dana C Crawford, Shiv Srivastava, Jennifer Cullen, Gyorgy Petrovics, Graham Casey, Ying Wang, Yao Tettey, Joseph Lachance, Wei Tang, Richard B Biritwum, Andrew A Adjei, Evelyn Tay, Ann Truelove, Shelley Niwa, Kosj Yamoah, Koveela Govindasami, Anand P Chokkalingam, Jacob M Keaton, Jacklyn N Hellwege, Peter E Clark, Mohamed Jalloh, Serigne M Gueye, Lamine Niang, Olufemi Ogunbiyi, Olayiwola Shittu, Olukemi Amodu, Akindele O Adebiyi, Oseremen I Aisuodionoe-Shadrach, Hafees O Ajibola, Mustapha A Jamda, Olabode P Oluwole, Maxwell Nwegbu, Ben Adusei, Sunny Mante, Afua Darkwa-Abrahams, Halimatou Diop, Susan M Gundell, Monique J Roobol, Guido Jenster, Ron H N van Schaik, Jennifer J Hu, Maureen Sanderson, Linda Kachuri, Rohit Varma, Roberta McKean-Cowdin, Mina Torres, Michael H Preuss, Ruth J F Loos, Matthew Zawistowski, Sebastian Zöllner, Zeyun Lu, Stephen K Van Den Eeden, Douglas F Easton, Stefan Ambs, Todd L Edwards, Reedik Mägi, Timothy R Rebbeck, Lars Fritsche, Stephen J Chanock, Sonja I Berndt, Fredrik Wiklund, Hidewaki Nakagawa, John S Witte, J Michael Gaziano, Amy C Justice, Nick Mancuso, Chikashi Terao, Rosalind A Eeles, Zsofia Kote-Jarai, Ravi K Madduri, David V Conti, Christopher A Haiman
The transferability and clinical value of genetic risk scores (GRSs) across populations remain limited due to an imbalance in genetic studies across ancestrally diverse populations. Here we conducted a multi-ancestry genome-wide association study of 156,319 prostate cancer cases and 788,443 controls of European, African, Asian and Hispanic men, reflecting a 57% increase in the number of non-European cases over previous prostate cancer genome-wide association studies. We identified 187 novel risk variants for prostate cancer, increasing the total number of risk variants to 451...
November 9, 2023: Nature Genetics
#20
RANDOMIZED CONTROLLED TRIAL
Jason L Vassy, Charles A Brunette, Matthew S Lebo, Katharine MacIsaac, Thomas Yi, Morgan E Danowski, Nicholas V J Alexander, Mark P Cardellino, Kurt D Christensen, Manish Gala, Robert C Green, Elizabeth Harris, Natalie E Jones, Benjamin J Kerman, Peter Kraft, Preetika Kulkarni, Anna C F Lewis, Steven A Lubitz, Pradeep Natarajan, Ashley A Antwi
Polygenic risk scores (PRSs) hold promise for disease risk assessment and prevention. The Genomic Medicine at Veterans Affairs (GenoVA) Study is addressing three main challenges to the clinical implementation of PRSs in preventive care: defining and determining their clinical utility, implementing them in time-constrained primary care settings, and countering their potential to exacerbate healthcare disparities. The study processes used to test patients, report their PRS results to them and their primary care providers (PCPs), and promote the use of those results in clinical decision-making are modeled on common practices in primary care...
November 2, 2023: American Journal of Human Genetics
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