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Keywords dexmedetomidine AND peripheral...

dexmedetomidine AND peripheral nerve blocks

https://read.qxmd.com/read/38489226/combined-dexamethasone-and-dexmedetomidine-as-adjuncts-to-popliteal-and-saphenous-nerve-blocks-in-patients-undergoing-surgery-of-the-foot-or-ankle-a-randomized-blinded-placebo-controlled-clinical-trial
#1
JOURNAL ARTICLE
Mathias Maagaard, Kamilia S Funder, Nikolaj K Schou, Jeannette Ø Penny, Peter Toquer, Jens Laigaard, Emma R Stormholt, Anders K Nørskov, Pia Jæger, Jakob H Andersen, Ole Mathiesen
BACKGROUND: Both dexamethasone and dexmedetomidine increase the duration of analgesia of peripheral nerve blocks. The authors hypothesized that combined intravenous dexamethasone and intravenous dexmedetomidine would result in a greater duration of analgesia when compared with intravenous dexamethasone alone and placebo. METHODS: The authors randomly allocated participants undergoing surgery of the foot or ankle under general anesthesia and with a combined popliteal (sciatic) and saphenous nerve block to a combination of 12 mg dexamethasone and 1 mcg/kg dexmedetomidine, 12 mg dexamethasone, or placebo (saline)...
March 14, 2024: Anesthesiology
https://read.qxmd.com/read/38477406/injectable-hydrogel-delivery-system-with-high-drug-loading-for-prolonging-local-anesthesia
#2
JOURNAL ARTICLE
Yongchun Li, You Chen, Yifan Xue, Jinlong Jin, Yixin Xu, Weian Zeng, Jie Liu, Jingdun Xie
Peripheral nerve block is performed for precise pain control and lesser side effects after surgery by reducing opioid consumption. Injectable hydrogel delivery systems with high biosafety and moisture content have good clinical application prospects for local anesthetic delivery. However, how to achieve high drug loading and long-term controlled release of water-soluble narcotic drugs remains a big challenge. In this study, heterogeneous microspheres and an injectable gel-matrix composite drug delivery system are designed in two steps...
March 13, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38469014/regional-anesthesia-for-arthroscopic-knee-repair-in-a-patient-with-hypertrophic-obstructive-cardiomyopathy-hocm-under-monitored-anesthesia-care-with-dexmedetomidine-infusion
#3
Julie J Cunningham, Andrew S Braun, Patrick Hussey, Amit Momaya, Promil Kukreja
Patients with hypertrophic obstructive cardiomyopathy (HOCM) who are scheduled for elective, noncardiac surgery present a distinctive challenge for perioperative healthcare providers. The use of general anesthesia and neuraxial anesthesia carries the risk of unpredictable hemodynamic changes and potential complications. Regional anesthesia (RA) emerges as a prudent and effective option for HOCM patients. RA provides advantages such as minimizing hemodynamic fluctuations, avoiding intubation, reducing pharmacologic side effects, facilitating enhanced recovery after surgery, and contributing to greater patient satisfaction...
February 2024: Curēus
https://read.qxmd.com/read/38253609/effects-of-combined-dexamethasone-and-dexmedetomidine-as-adjuncts-to-peripheral-nerve-blocks-a-systematic-review-with-meta-analysis-and-trial-sequential-analysis
#4
REVIEW
Mathias Maagaard, Jakob Hessel Andersen, Pia Jaeger, Ole Mathiesen
BACKGROUND/IMPORTANCE: The effects of combining dexamethasone and dexmedetomidine on block duration are unclear. OBJECTIVE: To investigate the effects of combining dexamethasone and dexmedetomidine on block duration. EVIDENCE REVIEW: Systematic review of randomized controlled trials (RCTs) from Medline, Embase, CENTRAL, CINAHL, the Web of Science, and BIOSIS until June 8, 2023. RCTs with adults undergoing surgery with a peripheral nerve block randomized to combined dexamethasone and dexmedetomidine versus placebo or other adjuncts were eligible...
January 22, 2024: Regional Anesthesia and Pain Medicine
https://read.qxmd.com/read/38138885/perioperative-hypotension-in-patients-undergoing-orthopedic-upper-extremity-surgery-with-dexmedetomidine-sedation-a-retrospective-study
#5
JOURNAL ARTICLE
Sujin Baek, Jiyong Lee, Yong Sup Shin, Yumin Jo, Juyeon Park, Myungjong Shin, Chahyun Oh, Boohwi Hong
(1) Background: limited data exist regarding the occurrence of hypotension associated with dexmedetomidine use and its risk factors in the context of intraoperative sedation for patients receiving peripheral nerve blocks. (2) Method: This single-center retrospective study assessed the incidence of hypotension in patients undergoing orthopedic upper extremity surgery with brachial plexus blockade. Patients were classified into three groups: group N (non-sedated), group M (midazolam), and group D (dexmedetomidine), based on their primary intraoperative sedative use...
November 28, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/38137952/novel-techniques-for-musculoskeletal-pain-management-after-orthopedic-surgical-procedures-a-systematic-review
#6
REVIEW
Saud N Aldanyowi
Effective postoperative pain management is critical for recovery after orthopedic surgery, but often remains inadequate despite multimodal analgesia. This systematic review synthesizes evidence on innovative modalities for enhancing pain control following major orthopedic procedures. Fifteen randomized controlled trials and comparative studies evaluating peripheral nerve blocks, local anesthetic infiltration, cryotherapy, transcutaneous electrical stimulation, adjunct medications, and other techniques are included...
December 15, 2023: Life
https://read.qxmd.com/read/38040604/efficacy-of-adjuvant-dexmedetomidine-on-penile-block-for-pediatric-hypospadias-repair
#7
JOURNAL ARTICLE
Amirali Khosravi, Simin Azemati, Golnar Gharaati, Mehdi Shirazi, Laleh Dehghanpisheh, Naeimehossadat Asmarian
INTRODUCTION: The management of postoperative pain, particularly in younger children, presents a challenge due to their limited ability to articulate the intensity of pain, lower pain threshold, and restricted availability of approved analgesics for pediatric use. Peripheral nerve blocks may be favored over neuraxial blocks because they allow quicker mobilization after surgery. OBJECTIVE: The present study aims to investigate the potential impact of adding dexmedetomidine to a local anesthetic (bupivacaine) on the analgesic efficacy in dorsal penile nerve block in hypospadias repair surgery...
November 20, 2023: Journal of Pediatric Urology
https://read.qxmd.com/read/37957753/periarticular-infiltration-used-in-total-joint-replacements-an-update-and-review-article
#8
REVIEW
Gavin Anthony King, Alexander Le, Michaela Nickol, Bianca Sarkis, Johannes Michiel van der Merwe
Periarticular infiltration following total knee and hip arthroplasty has been demonstrated to be equivalent to peripheral nerve blocks for postoperative pain management. The ideal cocktail has not been established yet. We have conducted a literature search on PubMed and Embase. Our search criteria included randomized controlled trials (RCTs) and systematic reviews (SRs). We tried to only include the most recent studies to keep the information current. The included research focused at Dexmedetomidine, Liposomal Bupivacaine, Ropivacaine, Epinephrine, Ketorolac, Morphine, Ketamine and Glucocorticosteroids...
November 13, 2023: Journal of Orthopaedic Surgery and Research
https://read.qxmd.com/read/37937437/peripheral-nerve-block-adjuncts-which-medication-to-choose-a-narrative-review-of-the-current-literature
#9
REVIEW
Robert Vietor, Roland Kiendrebeogo, Erin Tracy, Anthony R Plunkett
Enhancing the effect of peripheral nerve blockade by adding other classes of medications has long history of trial and error. Studies have identified multiple potentially beneficial adjuncts that work to either speed the onset of analgesia or prolong its duration. The benefits of these adjuncts must be weighed against the risks of systemic negative side effects. To date, the most commonly used adjuncts, and ones with the most robust scientific efficacy are, dexamethasone, dexmedetomidine and buprenorphine. This narrative review will discuss several classes of local anesthetic adjuncts and provide evidence for the clinical efficacy and side effect profile of the most commonly studied medications...
November 2023: Pain Management
https://read.qxmd.com/read/37916376/peng-block-associated-with-dexmedetomidine-sedation-for-intramedullary-femoral-fixation-in-high-risk-elderly-patients-a-case-series-and-review-of-the-literature
#10
REVIEW
A Vergari, E Console, R Nestorini, L Frassanito, A Piersanti, F Sbaraglia, F Della Sala, D De Padova, G Ferrone, M Rossi
BACKGROUND: Hip fracture is a major cause of hospitalization among the elderly population. The standard surgical treatment involves early repair to reduce mortality and morbidity. One type of treatment in the case of intertrochanteric and subtrochanteric fractures is intramedullary nailing, as it decreases soft tissue damage and permits early weight bearing. The most common anesthesia technique combines spinal anesthesia with a peripheral block. In cases where spinal anesthesia is contraindicated, general anesthesia is preferred...
October 2023: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/37842428/continuous-erector-spinae-and-serratus-intercostal-block-with-ketamine-dexmedetomidine-sedation-for-quadrantectomy-and-axillary-dissection-in-a-multimorbid-patient
#11
Massimiliano Luca D'Agostino, Paolo Scimia, Antonio De Cato, Marta Muscelli, Chiara Angeletti
Multimorbidity is a clinical presentation that poses an increased risk of perioperative and postoperative complications. Tailored anaesthetic management could potentially minimise the risk of negative outcomes. Peripheral nerve and fasciae blocks are valid strategies for perioperative and postoperative pain management, which avoid complications related to general anaesthesia and reduce the risk of intensive care unit admission as well as the hospital length of stay. We describe the case of a 56-old patient with multimorbidity, including obesity with a BMI of 45...
September 2023: Curēus
https://read.qxmd.com/read/37678396/living-liver-donor-pain-management
#12
JOURNAL ARTICLE
Ryung A Kang, Justin Sangwook Ko
PURPOSE OF REVIEW: Optimal pain control in living liver donors undergoing hepatectomy is strongly recommended considering their unique status as healthy individuals willingly undergoing surgery for the benefit of the recipient. This review aims to examine and evaluate different strategies aimed at ensuring effective postoperative pain management in living liver donors. RECENT FINDINGS: Enhanced recovery after surgery (ERAS) protocols have proven effective in optimizing patient outcomes, including in living liver donor hepatectomy...
September 8, 2023: Current Opinion in Organ Transplantation
https://read.qxmd.com/read/37568489/local-periarticular-infiltration-with-dexmedetomidine-results-in-superior-patient-well-being-after-total-knee-arthroplasty-compared-with-peripheral-nerve-blocks-a-randomized-controlled-clinical-trial-with-a-follow-up-of-two-years
#13
JOURNAL ARTICLE
Patrick Reinbacher, Gregor A Schittek, Alexander Draschl, Andrzej Hecker, Andreas Leithner, Sebastian Martin Klim, Kevin Brunnader, Amir Koutp, Georg Hauer, Patrick Sadoghi
BACKGROUND: This study aimed to compare local periarticular infiltration (LIA) with ultra-sound guided regional anesthesia (USRA) with ropivacaine and dexmedetomidine as an additive agent in primary total knee arthroplasty (TKA). METHODS: Fifty patients were randomized into two groups in a 1:1 ratio. Patients in the LIA group received local periarticular infiltration into the knee joint. The USRA group received two single-shot USRA blocks. Functional outcomes and satisfaction (range of movement, Knee Society Knee Score, Western Ontario and McMaster Universities Osteoarthritis Index, Oxford Knee Score, and Forgotten Joint Score), including well-being, were analyzed preoperatively and at five days, six weeks, and one and two years postoperatively...
August 2, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/37525735/a-comparative-evaluation-of-combined-nerve-block-versus-periarticular-infiltration-on-postoperative-pain-relief-in-total-hip-arthroplasty
#14
JOURNAL ARTICLE
Akhil Wadhawan, Sumit Arora, Anant Krishna, Mainak Mandal, Anju Bhalotra, Manoj Kumar
INTRODUCTION: To minimize the side effects of the central neuraxial blockade to obtain postoperative pain relief, there has been an increasing preference for targeting the peripheral structures in patients undergoing total hip arthroplasty (THA). PATIENTS AND METHODS: This prospective study was performed between September 2019 and September 2021 and involved 30 patients that were randomized to two groups. One group ( n  = 15) received combined nerve block (CNB) [obturator nerve, nerve to quadratus femoris, superior gluteal nerve, and femoral nerve], while another group ( n  = 15) received periarticular infiltrative analgesia (PIA)...
August 2023: Indian Journal of Orthopaedics
https://read.qxmd.com/read/37461798/dexmedetomidine-as-an-adjunct-in-a-fluoroscopically-guided-stellate-ganglion-block-for-complex-regional-pain-syndrome
#15
Haris Sheikh, Tanveer Baig
Complex regional pain syndrome (CRPS) is a chronic pain disorder characterized by pain that is disproportionate to the inciting event. Autonomic and inflammatory responses predominate, and treatment plans that explicitly target these responses reduce symptoms for longer periods of time, are typically better tolerated, and have more favorable outcomes. Our patient was a young male who presented with a four-month history of a road traffic accident (RTA) that resulted in a fractured left distal radius and scaphoid...
June 2023: Curēus
https://read.qxmd.com/read/37396910/comparison-of-dexmedetomidine-and-dexamethasone-as-adjuvants-to-the-ultrasound-guided-interscalene-nerve-block-in-arthroscopic-shoulder-surgery-a-systematic-review-and-bayesian-network-meta-analysis-of-randomized-controlled-trials
#16
Xiu-Min Wei, Zheng Liu, Lian-Chao Lv, Guang-Han Wu, Peng-Yu Sun, Chang-Ping Gu, Peng-Cai Shi
INTRODUCTION: Interscalene block (ISB) is widely regarded as the gold standard treatment for acute pain following arthroscopic shoulder surgery. However, a single injection of a local anesthetic for ISB may not offer sufficient analgesia. Various adjuvants have been demonstrated to prolong the analgesic duration of the block. Hence, this study aimed to assess the relative efficacy of dexamethasone and dexmedetomidine as adjuncts to prolong the analgesic duration for a single- shot ISB...
2023: Frontiers in Medicine
https://read.qxmd.com/read/37391982/dexmedetomidine-as-an-adjuvant-to-bupivacaine-in-caudal-analgesia-in-children-undergoing-infra-umbilical-surgery
#17
RANDOMIZED CONTROLLED TRIAL
M M Haque, D Banik, A K Akhtaruzzaman, D K Bhowmick, M A Kader, R Reza, M M Morshed, M Hasanuzzaman, A K Azad, M L Mariom, M S Hossain, M Masud, N Sultana
When performing infra-umbilical procedures, caudal epidural analgesia with bupivacaine is frequently used to provide both intra- and post-operative analgesia. Dexmedetomidine, an alpha 2 agonistsare extensively used in neuraxial blocks and peripheral nerve blocks to prolong the action of bupivacaine. To find out the effects of dexmedetomidine as an adjuvant to bupivacaine for caudal analgesia in children undergoing infra-umbilical surgery. This was a randomized, controlled double-blinded prospective observational study and was performed from July 2019 to December 2019...
July 2023: Mymensingh Medical Journal: MMJ
https://read.qxmd.com/read/37337656/the-effect-of-adjuvants-added-to-local-anaesthetics-for-single-injection-upper-extremity-peripheral-regional-anaesthesia-a-systematic-review-with-network-meta-analysis-of-randomised-trials
#18
COMMENT
Ann-Kristin Schubert, Vera Seneviratne, Jessica Stolz, Thomas Wiesmann, Hinnerk Wulf, Leopold Eberhart, Hanns-Christian Dinges
BACKGROUND: Peripheral regional anaesthesia is frequently used for upper extremity surgery. To prolong the duration of analgesia, adjuvants can be added to single-injection local anaesthetics. Despite attempts to compare several adjuvants in pairwise meta-analyses, a comprehensive comparison is still missing. OBJECTIVE: The objective of this network meta-analysis was to determine the effectiveness of adjuvants in upper extremity peripheral nerve blocks. DESIGN: A systematic review of randomised controlled trials with network meta-analyses...
September 1, 2023: European Journal of Anaesthesiology
https://read.qxmd.com/read/37314172/local-anaesthetic-adjuncts-for-peripheral-nerve-blockade
#19
REVIEW
Neel Desai, Eric Albrecht
PURPOSE OF REVIEW: Moderate-to-severe pain is common and remains a significant problem. Compared with opioid analgesia alone, single-shot peripheral nerve blockade has been associated with improved pain relief and the potential of decreased side effects. Single-shot nerve blockade, however, is limited by its relatively short duration of action. In this review, we aim to summarize the evidence related to local anaesthetic adjuncts for peripheral nerve blockade. RECENT FINDINGS: Dexamethasone and dexmedetomidine exhibit characteristics that most closely resemble the ideal local anaesthetic adjunct...
October 1, 2023: Current Opinion in Anaesthesiology
https://read.qxmd.com/read/37303417/comparative-evaluation-of-dexmedetomidine-and-dexamethasone-as-adjuvants-in-supraclavicular-brachial-plexus-block
#20
JOURNAL ARTICLE
Nagaraju A, Lingaraj Sahu, Sudeepa Das, Manoja Muni
Introduction Currently, peripheral nerve block has shown immense potential with effective patient satisfaction. In the event of upper limb surgeries, the supraclavicular brachial plexus approach under ultrasound guidance renders quick and dense anesthesia. In addition, the clinical utility of adjuvants with local anesthetics elicits a good quality of nerve block with improved duration and inset. So the aim of the present study was to compare the block characteristics of dexmedetomidine and dexamethasone during supraclavicular brachial plexus block in patients undergoing upper limb surgeries...
May 2023: Curēus
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