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https://www.readbyqxmd.com/read/29689105/cerebral-desaturation-in-heart-failure-potential-prognostic-value-and-physiologic-basis
#1
Yu-Jen Chen, Jong-Shyan Wang, Chih-Chin Hsu, Pyng-Jing Lin, Feng-Chun Tsai, Ming-Shien Wen, Chi-Tai Kuo, Shu-Chun Huang
Cerebral tissue oxygen saturation (SctO2) reflects cerebral perfusion and tissue oxygen consumption, which decline in some patients with heart failure with reduced ejection fraction (HFrEF) or stroke, especially during exercise. Its physiologic basis and clinical significance remain unclear. We aimed to investigate the association of SctO2 with oxygen transport physiology and known prognostic factors during both rest and exercise in patients with HFrEF or stroke. Thirty-four HFrEF patients, 26 stroke patients, and 17 healthy controls performed an incremental cardiopulmonary exercise test using a bicycle ergometer...
2018: PloS One
https://www.readbyqxmd.com/read/29672229/the-effects-of-mild-hypothermia-on-self-paced-exercise-performance
#2
Steven A H Ferguson, Neil Derek Eves, Brian D Roy, Gary J Hodges, Stephen S Cheung
This study examined self-paced, high-intensity exercise during mild hypothermia and whether hyperoxia may offset any potential impairment. Twelve trained males each completed 15 km time trials in three environmental conditions: Neutral (23{degree sign}C, Fi O2 : 0.21), Cold (0{degree sign}C, Fi O2 : 0.21), and Cold+Hyper (0{degree sign}C, Fi O2 : 0.40). Cold and Cold+Hyper trials occurred after a 0.5{degree sign}C drop in rectal temperature. Rectal temperature was higher (p{less than or equal to}0.016) throughout Neutral compared to Cold and Cold+Hyper; Cold had a higher (p{less than or equal to}0...
April 19, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29665297/esmolol-acutely-alters-oxygen-supply-demand-balance-in-exercising-muscles-of-healthy-humans
#3
David N Proctor, J Carter Luck, Stephan R Maman, Urs A Leuenberger, Matthew D Muller
Beta-adrenoreceptor antagonists (β blockers) reduce systemic O2 delivery and blood pressure (BP) during exercise, but the subsequent effects on O2 extraction within the active limb muscles are unknown. In this study, we examined the effects of the fast-acting, β1 selective blocker esmolol on systemic hemodynamics and leg muscle O2 saturation (near infrared spectroscopy, NIRS) during submaximal leg ergometry. Our main hypothesis was that esmolol would augment exercise-induced reductions in leg muscle O2 saturation...
April 2018: Physiological Reports
https://www.readbyqxmd.com/read/29652758/is-inspiratory-muscle-weakness-a-determinant-of-endurance-exercise-tolerance-during-niv-supported-exercise-in-patients-with-copd
#4
Rodrigo Koch, Gabriel Victor Guimarães Rapello, Paulo de Tarso Müller
PURPOSE: Previous research has reported that inspiratory muscle weakness is critical to decreased exercise tolerance and exercise tolerance improves with 10 cmH2O pressure support ventilation in patients with chronic obstructive pulmonary disease (COPD). The purpose of this study was to evaluate the effects of proportional assist ventilation (PAV) and continuous positive airway pressure (CPAP) compared with sham on exercise tolerance in patients with and without inspiratory muscle weakness...
April 11, 2018: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/29624723/randomized-clinical-trial-of-rt001-early-signals-of-efficacy-in-friedreich-s-ataxia
#5
Theresa Zesiewicz, Frederic Heerinckx, Robert De Jager, Omid Omidvar, Marcus Kilpatrick, Jessica Shaw, Mikhail S Shchepinov
BACKGROUND: RT001 is a deuterated ethyl linoleate that inhibits lipid peroxidation and is hypothesized to reduce cellular damage and recover mitochondrial function in degenerative diseases such as Friedreich's ataxia. OBJECTIVE: To evaluate the safety, pharmacokinetics, and preliminary efficacy of RT001 in Friedreich's ataxia patients. DESIGN/METHODS: We conducted a phase I/II double-blind, comparator-controlled trial with 2 doses of RT001 in Friedreich's ataxia patients (9 subjects each cohort)...
April 6, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29611324/validation-of-a-novel-wearable-wireless-technology-to-estimate-oxygen-levels-and-lactate-threshold-power-in-the-exercising-muscle
#6
Parisa Farzam, Zack Starkweather, Maria A Franceschini
There is a growing interest in monitoring muscle oxygen saturation (SmO2 ), which is a localized measure of muscle oxidative metabolism and can be acquired continuously and noninvasively using near-infrared spectroscopy (NIRS) methods. Most NIRS systems are cumbersome, expensive, fiber coupled devices, with use limited to lab settings. A novel, low cost, wireless, wearable has been developed for use in athletic training. In this study, we evaluate the advantages and limitations of this new simple continuous-wave (CW) NIRS device with respect to a benchtop, frequency-domain near-infrared spectroscopy (FDNIRS) system...
April 2018: Physiological Reports
https://www.readbyqxmd.com/read/29549005/influence-of-dietary-nitrate-supplementation-on-lung-function-and-exercise-gas-exchange-in-copd-patients
#7
Mehrdad Behnia, Courtney M Wheatley, Alberto Avolio, Bruce D Johnson
BACKGROUND: During exercise as pulmonary blood flow rises, pulmonary capillary blood volume increases and gas exchange surface area expands through distention and recruitment. We have previously demonstrated that pulmonary capillary recruitment is limited in COPD patients with poorer exercise tolerance. Hypoxia and endothelial dysfunction lead to pulmonary vascular dysregulation possibly in part related to nitric oxide related pathways. PURPOSE: To determine if increasing dietary nitrate might influence lung surface area for gas exchange and subsequently impact exercise performance...
March 13, 2018: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/29541131/oxygen-delivery-is-not-a-limiting-factor-during-post-exercise-recovery-in-healthy-young-adults
#8
Robert T Mankowski, Victor M Niemeijer, Jasper P Jansen, Lotte Spraakman, Henk J Stam, Stephan F E Praet
Purpose: It is still equivocal whether oxygen uptake recovery kinetics are limited by oxygen delivery and can be improved by supplementary oxygen. The present study aimed to investigate whether measurements of muscle and pulmonary oxygen uptake kinetics can be used to assess oxygen delivery limitations in healthy subjects. Methods: Sixteen healthy young adults performed three sub-maximal exercise tests (6 min at 40% Wmax ) under hypoxic (14%O2 ), normoxic (21%O2 ) and hyperoxic (35%O2 ) conditions on separate days in randomized order...
June 2017: Journal of Exercise Science and Fitness
https://www.readbyqxmd.com/read/29530621/right-ventricular-systolic-dysfunction-at-rest-is-not-related-to-decreased-exercise-capacity-in-patients-with-a-systemic-right-ventricle
#9
Frederik Helsen, Pieter De Meester, Alexander Van De Bruaene, Charlien Gabriels, Béatrice Santens, Mathias Claeys, Guido Claessen, Kaatje Goetschalckx, Roselien Buys, Marc Gewillig, Els Troost, Jens-Uwe Voigt, Piet Claus, Jan Bogaert, Werner Budts
BACKGROUND: To evaluate the relationship between right ventricular (RV) systolic dysfunction at rest and reduced exercise capacity in patients with a systemic RV (sRV). METHODS: All patients with congenitally corrected transposition of the great arteries (ccTGA) or complete TGA after atrial switch (TGA-Mustard/Senning) followed in our institution between July 2011 and September 2017 who underwent cardiac imaging within a six-month time period of cardiopulmonary exercise testing (CPET) were analyzed...
June 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29518671/impact-of-group-singing-on-older-adult-health-in-senior-living-communities-a-pilot-study
#10
Musetta C Fu, Basia Belza, Huong Nguyen, Rebecca Logsdon, Steven Demorest
PURPOSE: Participating in a group-singing program may be beneficial to healthy aging through engaging in active music-making activities and breathing exercises. The purpose of this study was to assess the feasibility, acceptability, and impact of a 12-week group singing program on cognitive function, lung health and quality of life (QoL) of older adults. MATERIALS AND METHODS: A pre and post-test quasi-experimental design evaluated the impact of a group-singing program on older adult health...
February 23, 2018: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29517668/the-efficiency-of-endothelin-receptor-antagonist-bosentan-for-pulmonary-arterial-hypertension-associated-with-congenital-heart-disease-a-systematic-review-and-meta-analysis
#11
REVIEW
Hong-Yu Kuang, Yu-Hao Wu, Qi-Jian Yi, Jie Tian, Chun Wu, We Nian Shou, Tie-Wei Lu
BACKGROUND: Oral bosentan has been widely applied in pulmonary arterial hypertension associated with congenital heart disease (PAH-CHD). A systemic review and meta-analysis was conducted for a therapeutic evaluation of oral bosentan in both adult and pediatric patients with PAH-CHD. The acute responses and a long-term effect were respectively assessed in a comparison with baseline characteristics, and the improvement of exercise tolerance was analyzed. METHODS: PubMed, Medline, Embase, and Cochrane Central Register of clinical controlled trails or observational studies have been searched for a recording of bosentan effects on the PAH-CHD participants...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29498799/does-the-severity-of-interstitial-lung-disease-affect-the-gains-from-pulmonary-rehabilitation
#12
Sami Deniz, Hülya Şahin, Enver Yalnız
INTRODUCTION: Reduced exercise capacity is a main feature of Interstitial Lung Diseases (ILDs) and it is related to closely prognosis of these patients. Pulmonary Rehabilitation (PR) results to improve in peak exercise capacity, dyspnea and quality of life in ILDs. OBJECTIVES: We aimed to evaluate the benefits of PR in patients with ILDs and to determine whether there are similar gains in patients with severe ILD. METHODS: We recruited ILD stable patients...
March 2, 2018: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29471056/number-of-raised-steps-during-the-short-and-fast-step-test-a-functional-tool-to-assess-response-to-brief-and-intense-effort-involving-anaerobic-metabolism
#13
Davy Laroche, Morgane Mangin, Delphine Besson, Alexandre Naaim, Anaïs Gouteron, Jean-Marie Casillas
BACKGROUND: Although the initial anaerobic component of exercise adaptation is unavoidable, no specific functional test is available for use in routine non-sporting practice to evaluate it. OBJECTIVE: To assess the bioenergetic and biomechanical properties of the Short and Fast Step Test (SFST), which consists of walking up and down a step as many times as possible in 1minute and to analyse its ability to explore the initial anaerobic component of effort in comparison to a reference self-paced step test...
February 19, 2018: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29465549/cardiorespiratory-parameters-and-glycated-hemoglobin-of-patients-with-type-2-diabetes-after-a-rehabilitation-program
#14
RANDOMIZED CONTROLLED TRIAL
Natália da Silva Freitas Marques, Luiz Carlos de Abreu, Bárbara Vieira Dos Santos, Cândido Ferreira Rodrigues Neto, José Rener Cordeiro da Silva, Karine Ketlem de Souza Braga, Kariny da Silva Uchôa, Laila Maria Silva Moraes, Leillane Cristina de Paiva Ferreira, Natanael Guimaraes Ribeiro, Savio Lima Dos Santos, Tayná Almeida da Silva, Paulo Evaristo de Andrade, Rodrigo Daminello Raimundo
INTRODUCTION: Cardiovascular autonomic dysfunction reflex of the pathophysiology of diabetes mellitus (DM) favors an increase in morbidity and mortality related to cardiovascular events, and for this reason has been one of the most studied clinical entities. METHOD: An experimental study of a randomized clinical trial type was therefore proposed to analyze the hemodynamic and glycemic response after the practice of a rehabilitation program in patients with type 2 diabetes mellitus (T2DM)...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29411535/near-infrared-spectroscopy-detects-age-related-differences-in-skeletal-muscle-oxidative-function-promising-implications-for-geroscience
#15
Susie Chung, Ryan Rosenberry, Terence E Ryan, Madison Munson, Thomas Dombrowsky, Suwon Park, Aida Nasirian, Mark J Haykowsky, Michael D Nelson
Age is the greatest risk factor for chronic disease and is associated with a marked decline in functional capacity and quality of life. A key factor contributing to loss of function in older adults is the decline in skeletal muscle function. While the exact mechanism(s) remains incompletely understood, age-related mitochondrial dysfunction is thought to play a major role. To explore this question further, we studied 15 independently living seniors (age: 72 ± 5 years; m/f: 4/11; BMI: 27.6 ± 5.9) and 17 young volunteers (age: 25 ± 4 years; m/f: 8/9; BMI: 24...
February 2018: Physiological Reports
https://www.readbyqxmd.com/read/29401114/efficacy-of-a-structured-exercise-program-for-improving-functional-capacity-and-quality-of-life-in-patients-with-stage-3-and-4-sarcoidosis-a-randomized-controlled-trial
#16
Ilknur Naz, Sevgi Ozalevli, Serir Ozkan, Hulya Sahin
PURPOSE: This study investigated the effects of an exercise program on functional capacity and quality of life in patients with stage 3 and stage 4 sarcoidosis. METHODS: Eighteen patients with stage 3 and 4 sarcoidosis were recruited; 9 received 12 wk of supervised exercise training and 9 received usual care. Patients underwent the following evaluations at baseline and follow-up: 6-min walk test, maximal inspiratory and expiratory pressure tests, back and leg dynamometer test, modified Medical Research Council Dyspnea Scale, Fatigue Severity Scale, St George Respiratory Questionnaire, Short Form-36 Quality of Life Questionnaire, Hospital Anxiety and Depression Questionnaire, body plethysmography, carbon monoxide diffusing capacity test, and blood gas analysis...
March 2018: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/29389691/the-effect-of-ischemic-preconditioning-on-maximal-swimming-performance
#17
N Williams, M Russell, C J Cook, L P Kilduff
The effect of ischemic preconditioning (IPC) on swimming performance was examined. Using a randomized, crossover design, National-and International-level swimmers (n=20; 14 males, 6 females) participated in three trials (Con, IPC-2h, IPC-24h). Lower-body IPC (4 x 5 min bi-lateral blood-flow restriction at 160-228 mmHg, and 5 min reperfusion) was used 2- (IPC-2h) or 24-h (IPC-24h) before a self-selected (100 m, n=15; 200 m, n=5) swimming time-trial (TT). The Con trial used a sham intervention (15 mmHg) 2h prior to exercise...
January 30, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29372395/impaired-skeletal-muscle-oxygenation-following-allogeneic-hematopoietic-stem-cell-transplantation-is-associated-with-exercise-capacity
#18
Tatsushi Wakasugi, Shinichiro Morishita, Katsuji Kaida, Yusuke Itani, Norihiko Kodama, Kazuhiro Ikegame, Hiroyasu Ogawa, Kazuhisa Domen
INTRODUCTION: Impaired skeletal muscle oxygenation potentially contributes to reduced exercise capacity in allogeneic hematopoietic stem cell transplantation (allo-HSCT) patients during early recovery and may explain altered hemoglobin responses to exercise following allo-HSCT. We investigated whether skeletal muscle oxygenation parameters and hemoglobin parameters in the tibialis anterior decreased following allo-HSCT, and whether these results were associated with declines in exercise capacity...
January 25, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29369955/reliability-of-near-infrared-spectroscopy-for-measuring-intermittent-handgrip-contractions-in-sport-climbers
#19
Jiří Baláš, Jan Kodejška, Dominika Krupková, Johan Hannsmann, Simon Fryer
Baláš, J, Kodejška, J, Krupková, D, Hannsmann, J, and Fryer, S. Reliability of near-infrared spectroscopy for measuring intermittent handgrip contractions in sport climbers. J Strength Cond Res 32(2): 494-501, 2018-The use of near-infrared spectroscopy (NIRS) to investigate muscle oxygenation changes during physical tasks such as rock climbing has rapidly increased within recent years; yet, there is no known measure of reliability. The current study aimed to determine intersession reliability and minimal detectable change (MDC) of continuous wave NIRS parameters during intermittent handgrip contractions in rock climbers...
February 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29369000/cardiorespiratory-repercussions-according-to-the-abdominal-circumference-measurement-of-men-with-obstructive-respiratory-disorder-submitted-to-respiratory-physiotherapy
#20
Bruno Martinelli, Valéria Amorim Pires Di Lorenzo, Robison José Quitério, Alexandre Ricardo Pepe Ambrozin, Eduardo Aguilar Arca, Maurício Jamami
PURPOSE: To examine the effect of respiratory physiotherapy among men with obstructive respiratory disorder, in relation to abdominal circumference (AC). METHODS: Quasi-experimental study including 26 men split into two groups according to AC(cm): 1) < 102 (ACrisk-free); and 2) ≥ 102 (ACrisk). Heart rate variability (HRV), diastolic blood pressure (DBP), oxygen saturation (SpO2), FEV1/FVC, slow vital capacity (SVC), inspiratory capacity (IC), maximal inspiratory pressure (PImax), thoracoabdominal amplitude (AI) were measured: before (M1); 5 min after the physiotherapy (i...
January 25, 2018: Physiotherapy Theory and Practice
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