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Sadhana r. Joshi

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https://www.readbyqxmd.com/read/27742491/altered-breast-milk-components-in-preeclampsia-an-in-vitro-proton-nmr-spectroscopy-study
#1
Kamini Dangat, Deepti Upadhyay, Anitha Kilari, Uma Sharma, Nisha Kemse, Savita Mehendale, Sanjay Lalwani, Girija Wagh, Sadhana Joshi, Naranamangalam R Jagannathan
OBJECTIVE: To investigate the metabolic profile of milk on day 3 and at the 6th month of lactation in mothers with preeclampsia (PE) and normotensive mothers. STUDY DESIGN: Women with PE (n=29) and control women (n=31) were recruited for this study. Milk was collected on day 3 and at the 6th month of lactation. Proton NMR spectroscopy was used to identify 25 milk metabolites (alpha-lactose, beta-lactose, oligosaccharides, myo-inositol, alanine, glutamate, glutamine, glycine, histidine, isoleucine, leucine, lysine, phenylalanine, tyrosine, valine, acetone, citrate, creatine, phosphocreatine, acetate, choline, lactate, lipid, phosphocholine and glycerophosphocholine)...
October 12, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27678102/variable-methylation-potential-in-preterm-placenta-implication-for-epigenetic-programming-of-the-offspring
#2
Vinita V Khot, Preeti Chavan-Gautam, Savita Mehendale, Sadhana R Joshi
Children born preterm are reported to be at increased risk of developing noncommunicable diseases in later life. Altered placental DNA methylation patterns are implicated in fetal programming of adult diseases. Our earlier animal studies focus on micronutrients (folic acid, vitamin B12) and long-chain polyunsaturated fatty acids (LCPUFAs) that interact in the 1 carbon cycle, thereby influencing methylation reactions. Our previous studies in women delivering preterm show altered plasma levels of micronutrients and lower plasma LCPUFA levels...
September 27, 2016: Reproductive Sciences
https://www.readbyqxmd.com/read/27578106/placental-dha-and-mrna-levels-of-ppar%C3%AE-and-lxr%C3%AE-and-their-relationship-to-birth-weight
#3
Akshaya P Meher, Nisha Wadhwani, Karuna Randhir, Savita Mehendale, Girija Wagh, Sadhana R Joshi
BACKGROUND: A very large number of fatty acids play wide range of physiological roles in cellular growth and function in placental as well as fetal growth. However, docosahexaenoic acid (DHA), in addition to its critical role in cellular membranes, is known to act as a ligand for several nuclear receptors and regulates the activity of transcription factor families like peroxisome proliferator-activated receptor, liver X receptor (LXR), retinoid X receptor (RXR), and sterol regulatory element binding protein (SREBP)...
July 2016: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/27569259/effect-of-vitamin-b12-and-omega-3-fatty-acid-supplementation-on-brain-neurotrophins-and-cognition-in-rats-a-multigeneration-study
#4
Richa S Rathod, Amrita A Khaire, Anvita A Kale, Sadhana R Joshi
Vitamin B12 and omega-3 fatty acids are important nutrients required for neuronal functioning. We have demonstrated the beneficial effects of vitamin B12 and omega-3 fatty acid supplementation on brain neurotrophins and cognition in the first and second generation offspring. However, there is a need to examine if the effects are sustained in the third generation offspring. This study reports the effects of vitamin B12 and omega-3 fatty acid supplementation across three consecutive generations on brain neurotrophins like brain derived neurotrophic factor (BDNF); nerve growth factor (NGF) and cognitive performance in the third generation male offspring...
September 2016: Biochimie
https://www.readbyqxmd.com/read/26802939/supplementation-of-maternal-omega-3-fatty-acids-to-pregnancy-induced-hypertension-wistar-rats-improves-il10-and-vegf-levels
#5
Nisha G Kemse, Anvita A Kale, Sadhana R Joshi
OBJECTIVES: Our recent study demonstrates the beneficial effect of a combined supplementation of vitamin B12, folic acid, and docosahexaenoic acid in reducing the severity of pregnancy induced hypertension (PIH). It is also known to be associated with angiogenic imbalance and inflammation. The current study examines whether the individual/combined supplementation of folic acid, vitamin B12 and omega-3 fatty acid during pregnancy can ameliorate the inflammatory markers and restore the angiogenic balance in a rat model of PIH...
January 2016: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/26626477/reduced-maternal-erythrocyte-long-chain-polyunsaturated-fatty-acids-exist-in-early-pregnancy-in-preeclampsia
#6
Nisha S Wadhwani, Ankita S Narang, Savita S Mehendale, Girija N Wagh, Sanjay A Gupte, Sadhana R Joshi
The present prospective study examines proportions of maternal erythrocyte fatty acids across gestation and their association with cord erythrocyte fatty acids in normotensive control (NC) and preeclamptic pregnancies. We hypothesize that maternal fatty acid status in early pregnancy influences fetal fatty acid stores in preeclampsia. 137 NC women and 58 women with preeclampsia were included in this study. Maternal blood was collected at 3 time points during pregnancy (16-20th weeks, 26-30th weeks and at delivery)...
January 2016: Lipids
https://www.readbyqxmd.com/read/26552939/increased-homocysteine-levels-exist-in-women-with-preeclampsia-from-early-pregnancy
#7
Nisha S Wadhwani, Vidya V Patil, Savita S Mehendale, Girija N Wagh, Sanjay A Gupte, Sadhana R Joshi
OBJECTIVE: The present prospective study examines the levels of maternal plasma folate, vitamin B12 and homocysteine in normotensive control (NC) women and women with preeclampsia (PE) from early pregnancy till delivery. METHODS: The present study includes 126 NC and 62 PE women. Maternal blood was collected at 3 time points during pregnancy (T1 = 16th-20th weeks, T2 = 26th-30th weeks and T3 = at delivery). Levels of folate, vitamin B12 and homocysteine were estimated by the chemiluminescent microparticle immunoassay technology...
2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/26269153/regional-changes-of-placental-vascularization-in-preeclampsia-a-review
#8
REVIEW
Akriti S Sahay, Deepali P Sundrani, Sadhana R Joshi
Preeclampsia is characterized by vascular dysfunction and results in maternal and fetal morbidity and mortality. The placenta plays a critical role in the growth and development of the fetus, and recent studies indicate that placental architecture, oxygen availability, and oxidative stress indices vary across different regions of the placenta. Our earlier studies have reported altered maternal angiogenesis and differential placental gene expression and methylation patterns of angiogenic factors in women with preeclampsia when compared with normotensive women...
August 2015: IUBMB Life
https://www.readbyqxmd.com/read/26249019/beneficial-effects-of-omega-3-fatty-acids-and-vitamin-b12-supplementation-on-brain-docosahexaenoic-acid-brain-derived-neurotrophic-factor-and-cognitive-performance-in-the-second-generation-wistar-rats
#9
Richa S Rathod, Amrita A Khaire, Anvita A Kale, Sadhana R Joshi
In vegetarian population, vitamin B12 deficiency coexists with suboptimal levels of omega-3 fatty acids. Studies indicate a need for supplementation/fortification of vitamin B12 and omega-3 fatty acids to reduce the risk of brain disorders. We have described the effects of vitamin B12 and omega-3 fatty acid supplementation on brain development in F1 generation animals. The current study investigates the effects of vitamin B12 and omega-3 fatty acids supplementation on brain function and cognition. Pregnant Wistar rats were assigned the following groups: control, vitamin B12 deficient (BD), vitamin B12 deficient + omega-3 fatty acid (BDO), vitamin B12 supplemented (BS), vitamin B12 supplemented + omega-3 fatty acid (BSO)...
July 2015: BioFactors
https://www.readbyqxmd.com/read/26048785/meridianin-derivatives-as-potent-dyrk1a-inhibitors-and-neuroprotective-agents
#10
Rammohan R Yadav, Sadhana Sharma, Prashant Joshi, Abubakar Wani, Ram A Vishwakarma, Ajay Kumar, Sandip B Bharate
Meridianins are a group of marine-derived indole alkaloids which are reported to possess kinase inhibitory activities. In the present Letter, we report synthesis of N1-substituted and C-ring modified meridianin derivatives and their evaluation as Dyrk1A inhibitors and neuroprotective agents. Among the library of 52 compounds screened, morpholinoyl linked derivative 26b and 2-nitro-4-trifluoromethyl phenyl sulfonyl derivative 29v displayed potent inhibition of Dyrk1A with IC50 values of 0.5 and 0.53 μM, respectively...
August 1, 2015: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/25958298/maternal-omega-3-fatty-acids-and-micronutrients-modulate-fetal-lipid-metabolism-a-review
#11
REVIEW
Amrita A Khaire, Anvita A Kale, Sadhana R Joshi
It is well established that alterations in the mother's diet or metabolism during pregnancy has long-term adverse effects on the lipid metabolism in the offspring. There is growing interest in the role of specific nutrients especially omega-3 fatty acids in the pathophysiology of lipid disorders. A series of studies carried out in humans and rodents in our department have consistently suggested a link between omega-3 fatty acids especially docosahexaenoic acid and micronutrients (vitamin B12 and folic acid) in the one carbon metabolic cycle and its effect on the fatty acid metabolism, hepatic transcription factors and DNA methylation patterns...
July 2015: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/25889224/maternal-omega-3-fatty-acid-supplementation-to-a-vitamin-b12-deficient-diet-normalizes-angiogenic-markers-in-the-pup-brain-at-birth
#12
Richa S Rathod, Amrita A Khaire, Anvita A Kale, Sadhana R Joshi
Vitamin B12 and omega-3 fatty acids are critical for normal brain development and function and their deficiencies during pregnancy could have adverse effects on cognitive performance in children. Our earlier studies indicate that both maternal vitamin B12 and omega-3 fatty acids influence brain development by regulating the levels of neurotrophins. Literature suggests that there exists a cross talk between neurotrophins like nerve growth factor (NGF) and angiogenic factors like vascular endothelial growth factor (VEGF)...
June 2015: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/25813884/regional-differences-in-the-placental-levels-of-oxidative-stress-markers-in-pre-eclampsia
#13
Akriti S Sahay, Deepali P Sundrani, Girija N Wagh, Savita S Mehendale, Sadhana R Joshi
OBJECTIVE: To examine placental malondialdehyde (MDA), catalase, and glutathione peroxidase (GPx) levels in four placental regions among women with and without pre-eclampsia. METHODS: A cross-sectional study was conducted among women aged 18-35 years with a singleton pregnancy in Pune, India, between May 3, 2013, and June 16, 2014. Three groups were enrolled: normotensive; pre-eclampsia, delivered at term; and pre-eclampsia, delivered preterm. Samples were collected from the central and peripheral placental regions (maternal and fetal sides) immediately after delivery...
June 2015: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/25405347/a-combined-supplementation-of-omega-3-fatty-acids-and-micronutrients-folic-acid-vitamin-b12-reduces-oxidative-stress-markers-in-a-rat-model-of-pregnancy-induced-hypertension
#14
Nisha G Kemse, Anvita A Kale, Sadhana R Joshi
OBJECTIVES: Our earlier studies have highlighted that an altered one carbon metabolism (vitamin B12, folic acid, and docosahexaenoic acid) is associated with preeclampsia. Preeclampsia is also known to be associated with oxidative stress and inflammation. The current study examines whether maternal folic acid, vitamin B12 and omega-3 fatty acid supplementation given either individually or in combination can ameliorate the oxidative stress markers in a rat model of pregnancy induced hypertension (PIH)...
2014: PloS One
https://www.readbyqxmd.com/read/24803508/altered-methylation-and-expression-patterns-of-genes-regulating-placental-angiogenesis-in-preterm-pregnancy
#15
COMPARATIVE STUDY
Deepali P Sundrani, Umakar S Reddy, Preeti M Chavan-Gautam, Savita S Mehendale, Giriraj R Chandak, Sadhana R Joshi
INTRODUCTION: Altered angiogenesis has been implicated in the pathogenesis of various pregnancy complications, particularly preeclampsia. At present, there is a lack of data on the possible role of angiogenesis and its molecular mechanism in preterm pregnancy. We have previously reported reduced placental global DNA methylation levels in preterm pregnancy. Now, we have extended the study to examine plasma levels of angiogenic factors from maternal and cord blood and correlate them with placental promoter CpG methylation and messenger RNA expression of these angiogenic genes in preterm pregnancies...
December 2014: Reproductive Sciences
https://www.readbyqxmd.com/read/24749811/maternal-micronutrients-omega-3-fatty-acids-and-placental-ppar%C3%AE-expression
#16
Akshaya P Meher, Asmita A Joshi, Sadhana R Joshi
An altered one-carbon cycle is known to influence placental and fetal development. We hypothesize that deficiency of maternal micronutrients such as folic acid and vitamin B12 will lead to increased oxidative stress, reduced long-chain polyunsaturated fatty acids, and altered expression of peroxisome proliferator activated receptor (PPARγ) in the placenta, and omega-3 fatty acid supplementation to these diets will increase the expression of PPARγ. Female rats were divided into 5 groups: control, folic acid deficient, vitamin B12 deficient, folic acid deficient + omega-3 fatty acid supplemented, and vitamin B12 deficient + omega-3 fatty acid supplemented...
July 2014: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/24718301/a-longitudinal-study-of-circulating-angiogenic-and-antiangiogenic-factors-and-at1-aa-levels-in-preeclampsia
#17
Akriti S Sahay, Vidya V Patil, Deepali P Sundrani, Asmita A Joshi, Girija N Wagh, Sanjay A Gupte, Sadhana R Joshi
Our earlier studies of preeclampsia (PE) at delivery have demonstrated the alteration of one carbon cycle, reduced placental omega 3 fatty acids, altered circulating levels of angiogenic factors and differential placental gene-specific methylation patterns of angiogenic factors. This study was undertaken to examine changes in the levels of angiogenic factors and angiotensin II type 1 receptor autoantibodies (AT1-AAs) throughout gestation, from early pregnancy until delivery, in women with PE and to examine their association with cord angiogenic factors, blood pressure and infant weight...
August 2014: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/24076518/differential-expression-of-human-placental-neurotrophic-factors-in-preterm-and-term-deliveries
#18
Madhavi V Dhobale, Hemlata R Pisal, Savita S Mehendale, Sadhana R Joshi
Neurotrophic factors such as brain derived neurotrophic factor (BDNF) and nerve growth factor (NGF) are involved in development of the placenta and fetal brain. A series of human and animal studies in our department have shown that micronutrients (folic acid, vitamin B12) and omega 3 fatty acids like DHA are all interlinked in the one carbon cycle. Any alterations in one carbon components will lead to changes in methylation patterns that further affect the gene expression at critical periods of development resulting in complications during pregnancy...
December 2013: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/23845215/prenatal-omega-3-fatty-acid-supplementation-to-a-micronutrient-imbalanced-diet-protects-brain-neurotrophins-in-both-the-cortex-and-hippocampus-in-the-adult-rat-offspring
#19
Pratiksha S Sable, Anvita A Kale, Sadhana R Joshi
OBJECTIVE: Our earlier studies show that maternal diets imbalanced in micronutrients like folic acid and vitamin B12 reduced brain docosahexaenoic acid (DHA) and brain derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in the offspring at birth and postnatal d21. This study followed the offspring till 3 months to examine the hypothesis that impaired brain neurotrophins at birth and d21 due to altered maternal micronutrients can be reversed by prenatal omega 3 fatty acid but not a postnatal control diet leading to altered cognition in adult life...
November 2013: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/23795920/a-prospective-study-of-maternal-fatty-acids-micronutrients-and-homocysteine-and-their-association-with-birth-outcome
#20
Nisha S Wadhwani, Hemlata R Pisal, Savita S Mehendale, Sadhana R Joshi
Our earlier studies both in animals and in humans have indicated that micronutrients (folic acid, vitamin B12) and long-chain polyunsaturated fatty acids, especially docosahexaenoic acid (DHA), are interlinked in the one-carbon cycle, which plays an important role in fetal 'programming' of adult diseases. The present study examines the levels of maternal and cord plasma fatty acids, maternal folate, vitamin B12 and homocysteine in healthy mothers at various time points during pregnancy and also examine an association between them...
October 2015: Maternal & Child Nutrition
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