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https://www.readbyqxmd.com/read/29628762/erratum-development-of-transmucosal-patch-loaded-with-anesthetic-and-analgesic-for-dental-procedures-and-in-vivo-evaluation-corrigendum
#1
(no author information available yet)
[This corrects the article on p. 2901 in vol. 11, PMID: 27382279.].
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29611894/unravelling-a-new-catabolic-pathway-of-c-19-steroids-in-mycobacterium-smegmatis
#2
Lorena Fernández-Cabezón, Beatriz Galán, José L García
In this work, we have characterized the C-19+ gene cluster (MSMEG_2851 to MSMEG_2901) of Mycobacterium smegmatis. By in silico analysis we have identified the genes encoding enzymes involved in the modification of the A/B steroid rings during the catabolism of C-19 steroids in certain M. smegmatis mutants mapped in the PadR-like regulator (MSMEG_2868), that constitutively express the C-19+ gene cluster. By using gene complementation assays, resting-cell biotransformations and deletion mutants, we have characterized the most critical genes of the cluster, i...
April 3, 2018: Environmental Microbiology
https://www.readbyqxmd.com/read/29557854/cost-and-cost-effectiveness-of-a-demand-creation-intervention-to-increase-uptake-of-voluntary-medical-male-circumcision-in-tanzania-spending-more-to-spend-less
#3
Sergio Torres-Rueda, Mwita Wambura, Helen A Weiss, Marya Plotkin, Katharine Kripke, Joseph Chilongani, Hally Mahler, Evodius Kuringe, Maende Makokha, Augustino Hellar, Carl Schutte, Kokuhumbya J Kazaura, Daimon Simbeye, Gerry Mshana, Natasha Larke, Gissenge Lija, John Changalucha, Anna Vassall, Richard Hayes, Jonathan M Grund, Fern Terris-Prestholt
BACKGROUND: Although voluntary medical male circumcision (VMMC) reduces the risk of HIV acquisition, demand for services is lower among men in most at-risk age groups (ages 20-34 years). A randomised controlled trial was conducted to assess the effectiveness of locally-tailored demand creation activities (including mass media, community mobilisation and targeted service delivery) in increasing uptake of campaign-delivered VMMC among men aged 20-34 years. We conducted an economic evaluation to understand the intervention's cost and cost-effectiveness...
March 19, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29481343/unicompartmental-knee-arthroplasty-revision-to-tka-are-tibial-stems-and-augments-associated-with-improved-survivorship
#4
Peter L Lewis, David C Davidson, Stephen E Graves, Richard N de Steiger, William Donnelly, Alana Cuthbert
BACKGROUND: Some surgeons contend that unicompartmental knee arthroplasty (UKA) can easily be revised to a TKA when revision is called for, whereas others believe that this can be complex and technically demanding. There has been little research regarding the efficacy or rationale of using metal augmentation and tibial stem extensions when revising a UKA to a TKA. QUESTION/PURPOSES: (1) Is the use of stem extensions for the tibial component associated with increased survival when revising a UKA to a TKA? (2) Is the addition of modular augments associated with increased survival compared with stem extensions alone? (3) Is TKA design (minimally stabilized versus posterior-stabilized) or (4) tibial fixation (cemented versus cementless) associated with differences in survivorship? METHODS: Data from the Australian Orthopaedic Association National Joint Replacement Registry (AOANJRR) were used to analyze implant survival after revision of a UKA to a TKA, comparing results in which tibial components were used with and without modular components...
April 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29273664/postmarketing-studies-for-novel-drugs-approved-by-both-the-fda-and-ema-between-2005-and-2010-a-cross-sectional-study
#5
Jean-David Zeitoun, Joseph S Ross, Ignacio Atal, Alexandre Vivot, Nicholas S Downing, Gabriel Baron, Philippe Ravaud
OBJECTIVES: To characterise postmarketing studies for drugs that were newly approved by the US Food and Drug Administration and the European Medicines Agency. DESIGN AND SETTING: Cross-sectional analysis of postmarketing studies registered in ClinicalTrials.gov until September 2014 for all novel drugs approved by both regulators between 2005 and 2010. Regulatory documents from both agencies were used. PRIMARY AND SECONDARY OUTCOME MEASURES: All identified postmarketing studies were classified according to planned enrolment, funding, status and geographical location, and we determined whether studies studied the originally approved indication...
December 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/29187414/postpartum-management-of-hypertensive-disorders-of-pregnancy-a-systematic-review
#6
Alexandra E Cairns, Louise Pealing, James M N Duffy, Nia Roberts, Katherine L Tucker, Paul Leeson, Lucy H MacKillop, Richard J McManus
OBJECTIVES: Hypertensive disorders of pregnancy (HDP) affect one in ten pregnancies and often persist postpartum when complications can occur. We aimed to determine the effectiveness and safety of pharmacological interventions, other interventions and different care models for postpartum hypertension management. DESIGN: A systematic review was undertaken. Nine electronic databases, including Medline, were searched from inception to 16 March 2017. After duplicate removal, 4561 records were screened...
November 28, 2017: BMJ Open
https://www.readbyqxmd.com/read/29125681/2015-16-i-move-i-move-multicentre-case-control-study-in-europe-moderate-vaccine-effectiveness-estimates-against-influenza-a-h1n1-pdm09-and-low-estimates-against-lineage-mismatched-influenza-b-among-children
#7
Esther Kissling, Marta Valenciano, Francisco Pozo, Ana-Maria Vilcu, Annicka Reuss, Caterina Rizzo, Amparo Larrauri, Judit Krisztina Horváth, Mia Brytting, Lisa Domegan, Monika Korczyńska, Adam Meijer, Ausenda Machado, Alina Ivanciuc, Vesna Višekruna Vučina, Sylvie van der Werf, Brunhilde Schweiger, Antonino Bella, Alin Gherasim, Annamária Ferenczi, Katherina Zakikhany, Joan O Donnell, Iwona Paradowska-Stankiewicz, Frederika Dijkstra, Raquel Guiomar, Mihaela Lazar, Sanja Kurečić Filipović, Kari Johansen, Alain Moren
BACKGROUND: During the 2015/16 influenza season in Europe, the cocirculating influenza viruses were A(H1N1)pdm09 and B/Victoria, which was antigenically distinct from the B/Yamagata component in the trivalent influenza vaccine. METHODS: We used the test-negative design in a multicentre case-control study in twelve European countries to measure 2015/16 influenza vaccine effectiveness (VE) against medically attended influenza-like illness (ILI) laboratory-confirmed as influenza...
November 10, 2017: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/28875087/tracing-hepatitis-b-virus-hbv-genotype-b5-formerly-b6-evolutionary-history-in-the-circumpolar-arctic-through-phylogeographic-modelling
#8
Remco Bouckaert, Brenna C Simons, Henrik Krarup, T Max Friesen, Carla Osiowy
BACKGROUND: Indigenous populations of the circumpolar Arctic are considered to be endemically infected (>2% prevalence) with hepatitis B virus (HBV), with subgenotype B5 (formerly B6) unique to these populations. The distinctive properties of HBV/B5, including high nucleotide diversity yet no significant liver disease, suggest virus adaptation through long-term host-pathogen association. METHODS: To investigate the origin and evolutionary spread of HBV/B5 into the circumpolar Arctic, fifty-seven partial and full genome sequences from Alaska, Canada and Greenland, having known location and sampling dates spanning 40 years, were phylogeographically investigated by Bayesian analysis (BEAST 2) using a reversible-jump-based substitution model and a clock rate estimated at 4...
2017: PeerJ
https://www.readbyqxmd.com/read/28761700/a-novel-treadmill-protocol-for-exercise-testing-in-children-the-british-columbia-children-s-hospital-protocol
#9
D Kathryn Duff, Astrid M De Souza, Derek G Human, James E Potts, Kevin C Harris
BACKGROUND: Exercise testing in children is widely recommended for a number of clinical and prescriptive reasons. Many institutions continue to use the Bruce protocol for treadmill testing; however, with its incremental changes in speed and grade, it has challenges for practical application in children. We have developed a novel institutional protocol (British Columbia Children's Hospital (BCCH)), which may have better utility in paediatric populations. AIM: To determine if our institutional protocol yields similar peak responses in minute ventilation (VE), oxygen consumption (VO2), carbon dioxide production (VCO2), respiratory exchange ratio (RER), metabolic equivalents (METS) and heart rate (HR) when compared with the traditional Bruce protocol...
2017: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/28571677/brm-promoter-insertion-polymorphisms-increase-the-risk-of-cancer-a-meta-analysis
#10
Xi Ouyang, Xiao Long Ye, Hong Bo Wei
INTRODUCTION: Many studies have suggested that the BRM promoter insertion polymorphisms might be associated with susceptibility to many different types of cancer. However, previous studies reported contradictory results. This current meta-analysis was performed to address this issue. EVIDENCE ACQUISITION: A comprehensive search was conducted in multiple databases, including PubMed, Embase and China National Knowledge Infrastructure (CNKI). We collected relevant articles to explore the association between the BRM insertion polymorphisms and susceptibility of cancers...
August 30, 2017: Gene
https://www.readbyqxmd.com/read/28497594/the-impact-of-regulatory-action-on-the-co-prescribing-of-renin-angiotensin-system-blockers-in-uk-primary-care
#11
Craig Allen, Katherine Donegan
PURPOSE: The aim of this study was to assess the impact of regulatory action taken in June 2014 on the co-prescribing of renin-angiotensin system (RAS) blockers in UK primary care. METHODS: RAS blocker prescriptions, issued between 01/01/2009-30/06/2015, were extracted from the Clinical Practice Research Datalink to estimate the quarterly prevalence (number of patients with at least one co-prescription) and incidence (number of patients first receiving a RAS blocker co-prescription) of co-prescribing...
May 11, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28456547/visual-outcomes-following-bilateral-lmplantation-of-two-diffractive-trifocal-intraocular-lenses-in-10-084-eyes
#12
MULTICENTER STUDY
Rafael Bilbao-Calabuig, Andrea Llovet-Rausell, Julio Ortega-Usobiaga, Mercedes Martínez-Del-Pozo, Fernando Mayordomo-Cerdá, Celia Segura-Albentosa, Julio Baviera, Fernando Llovet-Osuna
PURPOSE: To investigate refractive and visual acuity outcomes, patient satisfaction, and spectacle independence at 3 months of 2 diffractive (non-toric) trifocal intraocular lenses (IOLs) in a large series of patients. DESIGN: Multicenter, retrospective, nonrandomized clinical study. METHODS: Patients underwent lens phacoemulsification and were implanted bilaterally with a diffractive trifocal IOL: FineVision Micro F (PhysIOL SA, Liège, Belgium) or AT Lisa tri 839MP (Carl Zeiss AG, Jena, Germany)...
July 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28217856/molecular-characterization-of-a-new-gene-cluster-for-steroid-degradation-in-mycobacterium-smegmatis
#13
Lorena Fernández-Cabezón, Esther García-Fernández, Beatriz Galán, José L García
The C-19 steroids 4-androstene-3,17-dione (AD), 1,4-androstadiene-3,17-dione (ADD) or 9α-hydroxy-4-androstene-3,17-dione (9OH-AD), which have been postulated as intermediates of the cholesterol catabolic pathway in Mycobacterium smegmatis, cannot be used as sole carbon and energy sources by this bacterium. Only the ΔkstR mutant which constitutively expresses the genes repressed by the KstR regulator can metabolize AD and ADD with severe difficulties but still cannot metabolize 9OH-AD, suggesting that these compounds are not true intermediates but side products of the cholesterol pathway...
July 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28033521/physical-activity-and-sedentary-behavior-in-people-with-major-depressive-disorder-a-systematic-review-and-meta-analysis
#14
REVIEW
Felipe Schuch, Davy Vancampfort, Joseph Firth, Simon Rosenbaum, Philip Ward, Thaís Reichert, Natália Carvalho Bagatini, Roberta Bgeginski, Brendon Stubbs
BACKGROUND: Low levels of physical activity (PA) and sedentary behavior (SB) are independent risk factors for cardiovascular disease and premature mortality in people with major depressive disorder (MDD). AIMS: Investigate levels of PA and SB and their predictors in people with MDD. METHODS: Electronic databases were searched from inception till 04/2016 for articles measuring PA and SB with a self-report questionnaire (SRQ) or objective measure (e...
March 1, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28025574/intervention-related-increases-in-preoperative-physical-activity-are-maintained-6-months-after-bariatric-surgery-results-from-the-bari-active-trial
#15
RANDOMIZED CONTROLLED TRIAL
D S Bond, J G Thomas, S Vithiananthan, J Unick, J Webster, G D Roye, B A Ryder, H C Sax
Higher preoperative physical activity (PA) strongly predicts higher post-operative PA in bariatric surgery (BS) patients, providing rationale for preoperative PA interventions (PAIs). However, whether PAI-related increases can be maintained post-operatively has not been examined. This study compared PA changes across pre- (baseline, post-intervention) and post-operative (6-month follow up) periods in participants randomized to 6 weeks of preoperative PAI or standard care control (SC). Of 75 participants initially randomized, 36 (PAI n=22; SC n=14) underwent BS...
March 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27890632/evidence-of-genotypes-1-and-3-of-avian-hepatitis-e-virus-in-wild-birds
#16
Xinquan Zhang, Ivana Bilic, Salome Troxler, Michael Hess
Although the presence of four genotypes of avian hepatitis E virus (HEV) in chickens has been demonstrated, its natural host range is still barely known. In this study, swab samples from 626 wild birds originating from 62 bird species were investigated for HEV detection by molecular methods. The aim was to explore the cross-species infection of avian HEV and to compare the genetic diversity between strains infecting chicken and wild birds. In total, 8 positive samples from 4 different bird species (song thrush, little owl, feral pigeon and common buzzard) were identified and further confirmed by partial sequencing of ORF3...
January 15, 2017: Virus Research
https://www.readbyqxmd.com/read/27878226/psychometric-properties-of-multidimensional-health-locus-of-control-a-and-general-self-efficacy-scale-in-civil-servants-elsa-brasil-musculoskeletal-study-elsa-brasil-msk
#17
Luciana A C Machado, Rosa W Telles, Luciana Costa-Silva, Sandhi M Barreto
Background: Health-related control and self-efficacy beliefs can be assessed in the general population using Multidimensional Health Locus of Control-A subscales (MHLC-A) and the General Self-Efficacy Scale (GSES), respectively. Objective: To test construct validity, internal consistency, reliability (test-retest) and ceiling and floor effects of Portuguese-Brazil versions of MHLC-A and GSES. Method: Civil servants (N=2901) enrolled in a large Brazilian cohort were included...
June 30, 2016: Brazilian Journal of Physical Therapy
https://www.readbyqxmd.com/read/27709265/increased-incidence-of-co-infection-in-critically-ill-patients-with-influenza
#18
MULTICENTER STUDY
Ignacio Martin-Loeches, Marcus J Schultz, Jean-Louis Vincent, Francisco Alvarez-Lerma, Lieuwe D Bos, Jordi Solé-Violán, Antoni Torres, Alejandro Rodriguez
BACKGROUND: Co-infection is frequently seen in critically ill patients with influenza, although the exact rate is unknown. We determined the rate of co-infection, the risk factors and the outcomes associated with co-infection in critically ill patients with influenza over a 7-year period in 148 Spanish intensive care units (ICUs). METHODS: This was a prospective, observational, multicentre study. Influenza was diagnosed using the polymerase chain reaction. Co-infection had to be confirmed using standard bacteriological tests...
January 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/27677621/trajectories-of-total-and-central-adiposity-throughout-adolescence-and-cardiometabolic-factors-in-early-adulthood
#19
J Araújo, H Barros, E Ramos, L Li
BACKGROUND/OBJECTIVES: Our aim was to identify trajectories of total and central adiposity from 13 to 21 years, and to investigate how adiposity changes at different phases of adolescence relate to adulthood cardiovascular risk factors. SUBJECTS/METHODS: This study included participants from a population-based cohort (EPITeen), Portugal. Body mass index (BMI) and waist circumference (WC) were measured at 13, 17 and 21 years, and sex- and age-specific z-scores were calculated...
December 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27555176/use-of-cuffed-tracheal-tubes-in-neonates-infants-and-children-a-practice-survey-of-members-of-the-society-of-pediatric-anesthesia
#20
Madhankumar Sathyamoorthy, Jerrold Lerman, Victoria I Okhomina, Alan D Penman
STUDY OBJECTIVE: This study aimed to characterize the current practice patterns with cuffed tracheal tubes (CTT) in neonates, infants, and children among members of the Society of Pediatric Anesthesia (SPA). DESIGN AND SETTING: An electronic mail survey was distributed using Survey Monkey to members of SPA between December 2013 and February 2014. Each member was permitted one response. PATIENTS/INTERVENTION/MEASUREMENTS: Not applicable as this is a practice survey study...
September 2016: Journal of Clinical Anesthesia
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