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chemotherapy toxicity nutrit supplement

Hiroshi Miyata, Masahiko Yano, Takushi Yasuda, Makoto Yamasaki, Kohei Murakami, Tomoki Makino, Kohei Nishiki, Keijiro Sugimura, Masaaki Motoori, Osamu Shiraishi, Masaki Mori, Yuichiro Doki
OBJECTIVES: Omega-3 (ω-3) fatty acids have potential positive effects during chemotherapy, such as body weight maintenance and muscle mass preservation. However, little is known about the effect this supplement might have on reducing chemotherapy-induced toxicities. The aim of this study was to determine the usefulness of ω-3 fatty acid supplementation in the reduction of chemotherapy-related toxicities. METHODS: Sixty-one patients undergoing neoadjuvant chemotherapy for esophageal cancer randomly received ω-3-rich enteral nutrition (EN; n = 31) or ω-3-poor EN support (n = 30) for 15 d during chemotherapy...
July 25, 2016: Nutrition
Eran Ben-Arye, Noah Samuels, Lee Hilary Goldstein, Kamer Mutafoglu, Suha Omran, Elad Schiff, Haris Charalambous, Tahani Dweikat, Ibtisam Ghrayeb, Gil Bar-Sela, Ibrahim Turker, Azza Hassan, Esmat Hassan, Bashar Saad, Omar Nimri, Rejin Kebudi, Michael Silbermann
BACKGROUND: The authors assessed the use of herbal medicine by Middle Eastern patients with cancer, as reported by their oncology health care professionals (HCPs). Herbal products identified by the study HCPs were evaluated for potential negative effects. METHODS: Oncology HCPs from 16 Middle Eastern countries received a 17-item questionnaire asking them to list 5 herbal products in use by their patients with cancer. A literature search (PubMed, Micromedex, AltMedDex, and the Natural Medicine Comprehensive Database) was conducted to identify safety-related concerns associated with the products listed...
February 15, 2016: Cancer
Bingna Cai, Hua Chen, Han Sun, Peng Wan, Huili Sun, Jianyu Pan
Chemotherapy is generally accompanied by undesirable side effects, such as immunosuppression and malnutrition, which reduce tolerance to cancer therapies. Prior studies have shown that immunonutrition improves the clinical outcomes of cancer patients. In this study, immunoregulatory polysaccharides from Crassostrea hongkongensis were included in a nutrition formula that was administered to S180 tumor-bearing mice in combination with 5-fluorouracil (5-FU) treatment. The C30-60% fraction of the polysaccharides was characterized as a branched polysaccharide, with a high amount of d-glucose (96...
January 2016: Food & Function
Vincenzo Flati, Giovanni Corsetti, Evasio Pasini, Anna Rufo, Claudia Romano, Francesco Saverio Dioguardi
Amino acids can modulate cell metabolism and control cell fate by regulating cell survival and cell death. The molecular mechanisms involved are mediated by the mTOR complexes mTORC1 and mTORC2 activity. These complexes are finely regulated and the continuous advancement of the knowledge on their composition and function is revealing that their balance may represent the condition that determines the cell fate. This is important for normal healthy cells but it is becoming clear, and it is even more important, that the balance of the mTORCs activity may also condition the cell fate of cancer cells...
2016: Anti-cancer Agents in Medicinal Chemistry
V E Khoronenko, M M Shemetova, O V Drozhzhina, V M Khomyakov, D D Sobolev
UNLABELLED: Despite a steady decline in the incidence in recent decades, gastric cancer remains one of the most frequent causes of death from cancer in the world. By the time of diagnosis the tumor process is locally advanced or generalized in nearly 70% of patients that reduces the possibility of radical surgical treatment. Peritoneal carcinomatosis is a one of the main causes of treatment failure. There patients need complex treatment with cytoreductive surgery and intraoperative hyperthermic intraperitoneal chemotherapy (IHIC) to improve the quality and duration of life...
January 2015: Anesteziologiia i Reanimatologiia
M Naik, M C Ward, T J Bledsoe, A M S Kumar, L A Rybicki, J P Saxton, B B Burkey, J F Greskovich, D J Adelstein, S A Koyfman
OBJECTIVES: Long term swallowing dysfunction in patients with oropharynx squamous cell carcinoma (OPSCC) treated with concurrent chemoradiation (CRT) is declining. While the use of intensity modulated radiotherapy (IMRT) is commonly believed to be a potential cause, we hypothesize that the increasing incidence of human papillomavirus (HPV) related disease may also favorably impact this outcome. MATERIALS AND METHODS: We reviewed 130 HPV+ and 17 HPV- patients with stage III-IV OPSCC treated exclusively with conventional 3-field radiotherapy with chemotherapy between 2002 and 2010...
August 2015: Oral Oncology
Anna Wiela-Hojeńska, Teresa Kowalska, Emilia Filipczyk-Cisarż, Łukasz Łapiński, Karol Nartowski
BACKGROUND: Modern anticancer chemotherapy can cause numerous adverse effects in the organism, whose functioning has already been disrupted by the neoplastic process itself. OBJECTIVES: The aim of the study was to evaluate and compare the frequency and severity of the toxicity of FOLFOX-4 and CLF-1 anticancer therapy in patients with colon cancer, and to analyze certain factors that might have increased the toxicity of the chemotherapy. MATERIAL AND METHODS: The study involved 64 patients suffering from generalized colon cancer, including 48 patients treated according to the FOLFOX-4 regimen and 16 patients treated according to the CLF-1 regimen...
January 2015: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Steven E Lipshultz, Peter Sambatakos, Michael Maguire, Ruchika Karnik, Samuel W Ross, Vivian I Franco, Tracie L Miller
Children diagnosed with cancer are now living longer as a result of advances in treatment. However, some commonly used anticancer drugs, although effective in curing cancer, can also cause adverse late effects. The cardiotoxic effects of anthracycline chemotherapy, such as doxorubicin, and radiation can cause persistent and progressive cardiovascular damage, emphasizing a need for effective prevention and treatment to reduce or avoid cardiotoxicity. Examples of risk factors for cardiotoxicity in children include higher anthracycline cumulative dose, higher dose of radiation, younger age at diagnosis, female sex, trisomy 21 and black race...
2014: Acta Haematologica
Ana Luisa Miranda-Vilela, Cesar K Grisolia, João Paulo F Longo, Raphael C A Peixoto, Marcos Célio de Almeida, Lilian Carla P Barbosa, Mariana M Roll, Flávia A Portilho, Luciana L C Estevanato, Anamélia L Bocca, Sônia N Báo, Zulmira G M Lacava
The development of therapeutic strategies to attenuate chemotherapy toxicity represents an area of great interest in cancer research, and among them is nutritional therapy based on antioxidants. As research on this topic is still controversial and scarce, we aim to investigate the effects of antioxidant supplementation with vitamin C, vitamin E or pequi oil, a carotenoid-rich oil extracted from pequi (Caryocar brasiliense), on doxorubicin (DX)-induced oxidative damage to normal cells in Ehrlich solid tumor-bearing mice...
November 2014: Journal of Nutritional Biochemistry
Michelle Harvie
Nutritional supplements are widely used among patients with cancer who perceive them to be anticancer and antitoxicity agents. Large-scale, randomized cancer prevention trials have mainly been negative, with some notable adverse and beneficial effects. For example, these trials showed that beta-carotene increases the risk of lung and stomach cancer, vitamin E increases prostate cancer and colorectal adenoma, and selenium reduces gastric and lung cancer in populations with low selenium levels but increase rates in those with higher levels...
2014: American Society of Clinical Oncology Educational Book
Jon Cacicedo, Francisco Casquero, Lorea Martinez-Indart, Olga Del Hoyo, Alfonso Gómez de Iturriaga, Irma Muruzabal, Claudia Carvajal, Elsira Bóveda, Blanca Ruiz, Armando Loayza, Begoña Usategui, Aurora Lasso, Eduardo Hortelano, Pedro Bilbao
AIM: To identify risk factors that influence weight loss in patients receiving radiotherapy. BACKGROUND: It is a well-known fact that cancer patients can be affected by malnutrition at the onset of the disease and during treatment due to the toxicity. Pretreatment weight loss alone does not predict those who will need nutritional supplementation. Instead, a variety of nutritional and tumor related factors needs to be taken into account. MATERIAL AND METHODS: A retrospective study was conducted on 129 patients with different tumor locations...
September 2012: Reports of Practical Oncology and Radiotherapy
Noah Samuels, Elad Schiff, Eran Ben-Arye
Patients with breast cancer frequently turn to complementary medical therapies, including non-herbal nutritional supplements (NHNS). A number of NHNS products have been shown to potentially reduce the incidence and severity of adjuvant treatment-related symptoms. We review the literature and summarise the potential beneficial effects of these products and address issues regarding the safety of this practice. We offer an evidence-based approach for advancing a dialogue between doctors and patients interested in NHNS for adjuvant treatment-related toxicities...
September 2014: BMJ Supportive & Palliative Care
Caroline C Henson, Sorrel Burden, Susan E Davidson, Simon Lal
BACKGROUND: Across the developed world, an estimated 150,000 to 300,000 people are treated annually with pelvic radiotherapy and 80% will develop gastrointestinal (GI) symptoms during treatment. Acute GI symptoms are associated with a greater risk of chronic, often debilitating, GI symptoms. Up to one-third of patients are malnourished before pelvic radiotherapy and up to four-fifths of patients lose weight during treatment. Malnutrition is linked to a higher risk of GI toxicity, which can lead to breaks in radiotherapy and early cessation of chemotherapy, thus compromising the efficacy of the primary cancer treatment...
2013: Cochrane Database of Systematic Reviews
Octavio Casbarien, Pablo Cresta, Carolina Silva, Maria S Feliu, Alejandra Badia, Norberto L Delgado, Alfredo Navigante, Nora Slobodianik
BACKGROUND: This is a preliminary study of a specific nutritional supplement -Supportan(®) - for the clinical support of patients with locally advanced head and neck (H&N) cancers who underwent treatment with concurrent radiochemotherapy (RT-CHT). MATERIAL AND METHODS: Seven patients received nutritional supplement (Supportan(®)) plus habitual diet during a median time of treatment with RT on 7.8 weeks plus concurrent weekly CHT(S). Specific serum protein fractions as a potential useful tool to evaluate the nutritional status were determined...
December 2013: Endocrine, Metabolic & Immune Disorders Drug Targets
Steven E Lipshultz, Thomas R Cochran, Vivian I Franco, Tracie L Miller
Treatment advances and higher participation rates in clinical trials have rapidly increased the number of survivors of childhood cancer. However, chemotherapy and radiation treatments are cardiotoxic and can cause cardiomyopathy, conduction defects, myocardial infarction, hypertension, stroke, pulmonary oedema, dyspnoea and exercise intolerance later in life. These cardiotoxic effects are often progressive and irreversible, emphasizing a need for effective prevention and treatment to reduce or avoid cardiotoxicity...
December 2013: Nature Reviews. Clinical Oncology
Sabino Strippoli, Vito Lorusso, Anna Albano, Michele Guida
BACKGROUND: Rhabdomyolysis is an uncommon side effect of trabectedin which is used for the second line therapy of metastatic sarcoma after anthracycline and ifosfamide failure. This side effect may be due to pharmacokinetic interactions caused by shared mechanisms of metabolism involving the cytochrome P450 (CYP) system in the liver. Here, for the first time in literature, we describe the unexpected onset of heavy toxicity, including rhabdomyolysis, after the fourth course of trabectedin in a patient with retroperitoneal liposarcoma who at the same time was taking an alternative herbal medicine suspected of triggering this adverse event...
2013: BMC Complementary and Alternative Medicine
S Antoun, B Besse, D Planchard, B Raynard
INTRODUCTION: Cancer treatments are based on specific anticancer chemotherapy. However, there is increasing interest in general aspects of care, which are increasingly evidence based. STATE OF THE ART: The importance of muscle mass is becoming increasingly evident. Its role is not only limited to the maintenance of physical performance and quality of life. In oncology, recent studies have shown a close link between sarcopenia (low muscle mass) and mortality as well as between sarcopenia and chemotherapy toxicity...
June 2013: Revue des Maladies Respiratoires
Dawn L Hershman, Joseph M Unger, Katherine D Crew, Lori M Minasian, Danielle Awad, Carol M Moinpour, Lisa Hansen, Danika L Lew, Heather Greenlee, Louis Fehrenbacher, James L Wade, Siu-Fun Wong, Gabriel N Hortobagyi, Frank L Meyskens, Kathy S Albain
PURPOSE: Chemotherapy-induced peripheral neuropathy (CIPN) is common and leads to suboptimal treatment. Acetyl-L-carnitine (ALC) is a natural compound involved in neuronal protection. Studies have suggested ALC may be effective for the prevention and treatment of CIPN. PATIENTS AND METHODS: A 24-week randomized double-blind trial comparing ALC (3,000 mg per day) with placebo in women undergoing adjuvant taxane-based chemotherapy was conducted. The primary objective was to determine if ALC prevents CIPN as measured by the 11-item neurotoxicity (NTX) component of the Functional Assessment of Cancer Therapy (FACT) -Taxane scale at 12 weeks...
July 10, 2013: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Eran Ben-Arye, Aaron Polliack, Elad Schiff, Tamar Tadmor, Noah Samuels
CONTEXT: Many cancer patients are using non-herbal nutritional supplements (NHNS), often without informing their oncologists. OBJECTIVES: To review the literature and summarize the beneficial effects and safety of NHNS in the prevention and reduction of treatment-related symptoms. METHODS: Databases were searched for randomized, controlled clinical trials (Jadad score ≥ 2) using AltHealthWatch, Cochrane Database of Systematic Reviews, Embase, MEDLINE, Memorial Sloan-Kettering Integrative Medicine Service Database, Natural Standard Database, and PubMed...
December 2013: Journal of Pain and Symptom Management
Katrin Sak
Chemotherapy has been used for cancer treatment already for almost 70 years by targeting the proliferation potential and metastasising ability of tumour cells. Despite the progress made in the development of potent chemotherapy drugs, their toxicity to normal tissues and adverse side effects in multiple organ systems as well as drug resistance have remained the major obstacles for the successful clinical use. Cytotoxic agents decrease considerably the quality of life of cancer patients manifesting as acute complaints and impacting the life of survivors also for years after the treatment...
2012: Chemotherapy Research and Practice
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