keyword
MENU ▼
Read by QxMD icon Read
search

sandostatin

keyword
https://www.readbyqxmd.com/read/29146893/von-hippel-lindau-disease-with-multi-organ-involvement-a-case-report-and-8-year-clinical-course-with-follow-up
#1
Ali Yaghobi Joybari, Payam Azadeh
BACKGROUND Von Hippel-Lindau (VHL) disease is a rare autosomal dominant syndrome manifested by a spectrum of benign and malignant tumors.  CASE REPORT The patient presented here was a 31-year-old female with unremarkable family history who presented initially complaining of intermittent abdominal pain. Abdominal CT scan revealed an inhomogeneous solid mass (13×9×7 cm) originating from the tail of the pancreas with splenic and gastric invasion as well as several pancreatic cysts. A nucleotide scan showed left adrenal involvement...
November 17, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/29127751/-the-benefit-of-new-angiogenesis-bevacizumab-and-aflibercept-inhibitors-for-multiple-angiomatosis-therapy-a%C3%A2-case-report
#2
Dagmar Brančíková, Lenka Ostřížková, Zdeněk Adam, Tomáš Nebeský, Luděk Pour, Zdeněk Král, Jiří Mayer
Angiomatosis is a term for multiple, gradually proliferating hemangiomas (angiodysplasia), affecting multiple organs or tissues at the same time. We describe a 12-year course of treatment of a patient with multiple hemangiomas located in the abdomen, retroperitoneum, oesophagus, mediastinum and also in vertebrae. The diagnosis was made in 2005 within probatory laparotomy, at the age of 28 years. The treatment was commenced right after making the diagnosis with interferon α. Due to its adverse effects (fatigue, anorexia), the use of interferon α was limited to the first year, after which the interferon dose was gradually being reduced until it was discontinued completely...
2017: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/28729431/sandostatin-lar-therapy-differentially-alters-68-ga-dotatate-uptake-in-normal-tissues-compared-to-primary-tumors-and-metastatic-lesions
#3
Narjess Ayati, Sze Ting Lee, Seyed Rasoul Zakavi, Kunthi Pathmaraj, Loai Qatawneh, Aurora Poon, Andrew Scott
Synthetic somatostatin analogs have been posed as a potential source of error in somatostatin receptor imaging by interfering with tumor detection; however, experimental models and clinical studies have shown a complex mechanism of octreotide effect on tumors. This study aimed to assess whether (68)Ga-DOTATATE uptake differs before and after treatment with long-acting somatostatin analogs. Methods: Thirty patients with intermediate to well differentiated neuroendocrine tumors (NET) who underwent (68)Ga-DOTATATE Positron Emission Tomography/Computed Tomography (PET/CT) scanning before and after receiving long-acting repeatable (LAR) Sandostatin were included in the study...
July 20, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28392414/micro-flow-imaging-as-a-quantitative-tool-to-assess-size-and-agglomeration-of-plga-microparticles
#4
Miranda M C van Beers, Cees Slooten, Jelte Meulenaar, Ahmad S Sediq, Ruud Verrijk, Wim Jiskoot
The purpose of this study was to explore the potential of flow imaging microscopy to measure particle size and agglomeration of poly(D,L-lactic-co-glycolic acid) (PLGA) microparticles. The particle size distribution of pharmaceutical PLGA microparticle products is routinely determined with laser diffraction. In our study, we performed a unique side-by-side comparison between MFI 5100 (flow imaging microscopy) and Mastersizer 2000 (laser diffraction) for the particle size analysis of two commercial PLGA microparticle products, i...
April 6, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28270045/evaluation-of-the-efficacy-of-octreotide-lar-in-the-treatment-of-crohn-s-disease-associated-refractory-diarrhea
#5
Laura Martelli, Arnaud Colard, Fernand Fontaine, Jacques Deflandre, Boris Bastens, Edouard Louis
OBJECTIVES: Diarrhea is one of the main symptoms of Crohn's disease (CD). It is usually significantly improved with specific CD treatments, loperamide or cholestyramine. However, in some cases, diarrhea becomes refractory. The aim of this study was to assess the safety and efficacy of octreotide in this situation. MATERIALS AND METHODS: Fifteen patients with CD refractory diarrhea defined by at least an average of five smooth or liquid stools per day despite an optimized CD treatment were included from three Belgian centers...
May 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/27894777/efficacy-of-long-acting-octreotide-on-reducing-mucus-production-in-patients-with-ileal-neobladder
#6
RANDOMIZED CONTROLLED TRIAL
Mohammad Hatef Khorrami, Amir Javid, Mohammad Hossein Izadpanahi, Farshid Alizadeh, Mahtab Zargham, Farbod Khorrami
PURPOSE: To evaluate the efficacy of long-acting-release octreotide (trade name Sandostatin) on decreasing mucus secretion, thus reducing catheter obstruction after radical cystectomy and orthotopic reconstruction. PATIENTS AND METHODS: In this double-blind, placebo-controlled study, we treated 73 cases of radical cystectomy between the years 2008 and 2014; 65 were deemed eligible for the study. Cases were randomly divided into 2 groups. Group A (n = 32) received 2 doses of 20 mg intramuscular long-acting-release octreotide 4 weeks before and on the day of surgery, while group B (n = 33) received placebo...
February 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/27843513/bilateral-choroidal-metastases-from-endobronchial-carcinoid-treated-with-somatostatin-analogues
#7
Deborah De Bruyn, Jan Lamont, Erik Vanderstraeten, Simon Van Belle, Elise Platteau, Julie De Zaeytijd, Kristien P Hoornaert
OBJECTIVE: To describe a patient with bilateral multifocal choroidal metastases from an endobronchial carcinoid treated with a somatostatin analogue. METHOD: A 60-year-old woman presenting with photopsia in the left eye underwent an extensive ophthalmic examination, including fluorescein angiography, OCT and ultrasound. RESULTS: Fundoscopy revealed a small retinal tear in the left eye, for which she received laser treatment. In addition, choroidal masses were detected in both eyes...
2016: Open Ophthalmology Journal
https://www.readbyqxmd.com/read/27697899/somatostatin-analogues-in-acromegaly-and-gastroenteropancreatic-neuroendocrine-tumours-past-present-and-future
#8
REVIEW
Kjell Öberg, Steven W J Lamberts
Acromegaly is a hormonal disorder that arises when the pituitary gland secretes excess growth hormone (GH), which in turn stimulates a concomitant increase in serum insulin-like growth factor 1 (IGF-1) levels. Gastroenteropancreatic neuroendocrine tumours (GEP-NET) constitute a heterogeneous group of tumours that can secrete serotonin and a variety of peptide hormones that may cause characteristic symptoms known as carcinoid syndrome or other symptoms and hormonal hypersecretion syndromes depending on the tumour's site of origin...
December 2016: Endocrine-related Cancer
https://www.readbyqxmd.com/read/27695956/octreotide-ameliorates-inflammation-and-apoptosis-in-acute-and-kindled-murine-ptz-paradigms
#9
COMPARATIVE STUDY
M Y Al-Shorbagy, Noha N Nassar
In the present study, the role of octreotide (OCT) in pentylenetetrazole (PTZ) kindling as well as in acute convulsion models was evaluated. Mice were allocated in groups as (1) control saline; (2) acute PTZ (PTZ-a; 60 mg/kg, i.p.), as a single convulsive dose; and (3) kindled (PTZ-k) receiving nine subconvulsive doses of PTZ (40 mg/kg, i.p.) for 17 days. Groups 4-7 received either valproic acid (VPA) 50 mg/kg or OCT (50 μg/kg, Sandostatin®) 30 min by oral gavage before PTZ-a or PTZ-k. The median seizure stage, latency onset of first stage 4/5 seizures, and incidence of convulsing animals were recorded...
January 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/27628685/perioperative-application-of-somatostatin-analogs-for-pancreatic-surgery-current-status-in-germany
#10
Andreas Volk, Philipp Nitschke, Franziska Johnscher, Nuh Rahbari, Thilo Welsch, Christoph Reißfelder, Jürgen Weitz, Marius Distler, Soeren Torge Mees
BACKGROUND: The most common major complication after pancreatic resection is the postoperative pancreatic fistula (POPF). Somatostatin analogs can reduce POPF, but the use of somatostatin analogs is still controversial. The aim of this study was to assess treatment algorithms for pancreatic surgery in Germany with a special focus on the application of somatostatin analogs. METHODS: A questionnaire evaluating the perioperative management-especially the use of somatostatin analogs-and postoperative complications after pancreatic surgery was developed and sent to 209 German hospitals performing >12 pancreatoduodenectomies per year (the requirement for certification as a pancreas center)...
November 2016: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/27284478/ki67-score-as-a-potential-predictor-in-the-selection-of-liver-directed-therapies-for-metastatic-neuroendocrine-tumors-a-single-institutional-experience
#11
Smit Singla, Charles M LeVea, Venkata K Pokuri, Kristopher M Attwood, Michael M Wach, Garin M Tomaszewski, Boris Kuvshinoff, Renuka Iyer
BACKGROUND: Neuroendocrine tumors (NETs) metastatic to the liver are treated with transarterial radioembolization (TARE) using yttrium-90 (Y-90) microspheres or transarterial chemoembolization (TACE). However the criteria for patient selection are not well defined. We sought to determine if Ki67 score could help select patients for one therapy over the other in the management of hepatic neuroendocrine metastases. METHODS: Single institution analysis of patients treated with Y-90 or TACE between 2001 and 2014...
June 2016: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/27040814/pharmacokinetic-and-pharmacodynamic-study-of-a-phospholipid-based-phase-separation-gel-for-once-a-month-administration-of-octreotide
#12
Mengxin Wang, Fengying Shan, Yang Zou, Xun Sun, Zhi-Rong Zhang, Yao Fu, Tao Gong
As a natural somatostatin analog, octreotide acetate (OCT) has been extensively used in cancer treatment and growth hormone related diseases. The clinical application of OCT, however, is greatly limited by its short half-life, rapid elimination and clearance in vivo. In the current study, a high content phospholipid-based phase separation gel platform (PPSG) was presented, which could be injected in the soluble state and underwent rapid phase-separation into a gel-like implant after a single subcutaneous injection...
May 28, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/26847353/hepatectomy-after-yttrium-90-y90-radioembolization-induced-liver-fibrosis
#13
Ajay V Maker, Carey August, Vijay K Maker, Elliot Weisenberg
An obese 55-year-old woman with nonalcoholic fatty liver disease presented 7 years after resection of a T3N1 ileal carcinoid tumor with an elevated chromogranin A, multifocal metastatic disease to the liver, and carcinoid syndrome. She underwent right hepatic artery yttrium-90 (Y90) radioembolization, followed a month later by selective Y90 treatment to segment IV. She then presented to our clinic 10 months later, remaining symptomatic with flushing, diarrhea, anxiety, myalgia, pain, and persistent night sweats despite Sandostatin administration...
April 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/26838946/problems-of-diagnostic-assessment-in-advanced-pancreatic-neuroendocrine-neoplasm-and-treatment-implications-a-case-report-and-literature-review
#14
Bartosz Szymanowski, Renata Duchnowska, Marek Bilski, Grażyna Łapińska, Beata Hryciuk, Grzegorz Kamiński, Cezary Szczylik
We are reporting a case of a 55-year-old woman who was diagnosed as having a non-functioning pancreatic neuroendocrine neoplasm (NF-PNEN), the World Health Organization (WHO) low grade (G1) with liver metastases. In the staging process the positron emission tomography - computed tomography with Fluorine-18-Fluorodeoxyglucose (F-FDG PET-CT) and spiral CT then the gallium-DOTA-octreotate positron emission tomography - computer tomography (⁶⁸Ga-DOTATATE PET-CT) shown difference in burden of disease. In first line therapy, everolimus (Afinitor®, Novartis Pharma GmbH, Germany) at the oral dose of 10 mg once daily and octreotide long-acting release (Sandostatin LAR®) 30 mg i...
2016: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/26744896/patient-reported-outcomes-of-parenteral-somatostatin-analogue-injections-in-195-patients-with-acromegaly
#15
MULTICENTER STUDY
Christian J Strasburger, Niki Karavitaki, Sylvère Störmann, Peter J Trainer, Ilonka Kreitschmann-Andermahr, Michael Droste, Márta Korbonits, Berit Feldmann, Kathrin Zopf, Violet Fazal Sanderson, David Schwicker, Dana Gelbaum, Asi Haviv, Martin Bidlingmaier, Nienke R Biermasz
BACKGROUND: Long-acting somatostatin analogues delivered parenterally are the most widely used medical treatment in acromegaly. This patient-reported outcomes survey was designed to assess the impact of chronic injections on subjects with acromegaly. METHODS: The survey was conducted in nine pituitary centres in Germany, UK and The Netherlands. The questionnaire was developed by endocrinologists and covered aspects of acromegaly symptoms, injection-related manifestations, emotional and daily life impact, treatment satisfaction and unmet medical needs...
March 2016: European Journal of Endocrinology
https://www.readbyqxmd.com/read/26610855/cushing-syndrome-secondary-to-ectopic-adrenocorticotropic-hormone-secretion-from-a-meckel-diverticulum-neuroendocrine-tumor-case-report
#16
Diana Loreta Paun, Lavinia Vija, Emilia Stan, Alexandra Banica, Elena Bobeica, Dana Terzea, Catalina Poiana, Corin Badiu, Sorin Paun
BACKGROUND: Ectopic production of adrenocorticotropic hormone (ACTH) by neuroendocrine tumours (NET) is a rare condition, occult presentations often hampering the diagnosis. Although NET are relatively frequent in the ileon and Meckel diverticulum, we describe the first Cushing's syndrome due to ectopic adrenocorticotropic syndrome (CS-EAS) arising from a Meckel diverticulum. CASE PRESENTATION: A 44-year-old man was admitted with recent onset of diabetes, myopathy, edema and hypokalemic metabolic alkalosis consistent with Cushing's syndrome...
November 26, 2015: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/26609262/effects-of-combination-therapy-somatostatin-analogues-and-dopamine-agonists-on-gh-and-igf1-levels-in-acromegaly
#17
Ana Valea, Cristina Ghervan, Mara Carsote, Andra Morar, Iulia Iacob, Florica Tomesc, Dan Dumitru Pop, Carmen Georgescu
BACKGROUND AND AIMS: Acromegaly is a complex endocrine disorder caused by excessive secretion of GH, secondary to a GH secreting pituitary adenoma or a mixed pituitary adenoma secreting GH and PRL. METHODS: The aim of this study was to evaluate the effects of combination therapy: dopamine agonist and somatostatin analogue on GH and IGF1 levels in a group of 30 patients with acromegaly. Cabergoline in a dose of 2 mg/week and 4 mg/week respectively was associated with Sandostatin LAR in a dose of 20 mg/month and 30 mg/months respectively...
2015: Clujul Medical (1957)
https://www.readbyqxmd.com/read/26293797/possible-role-of-tgf-%C3%AE-1-in-inflammatory-pseudotumor-associated-with-multiple-neuroendocrine-tumors-of-the-small-intestine
#18
Andrej Udelnow, Doerthe Jechorek, Cora Wex, Silke Klose, Maciej Pech, Annegret Reinhold, Frank Meyer
INTRODUCTION: Inflammatory myofibroblastic tumors (IMTs), a rare condition of unknown etiology, have often been reported to be associated with specific infections or malignant tumors. The question of whether IMT themselves are an inflammatory or a neoplastic process is still going on. CASE REPORT: A 57-year-old female patient was transferred to our hospital with ileus caused by a mesenterial tumor. Intraoperatively, the mesenteric mass and the dependent small intestine segment, as well as a suspect hepatic lesion, were resected...
October 2015: Pathology, Research and Practice
https://www.readbyqxmd.com/read/25958482/efficacy-of-long-acting-somatostatin-analogs-in-recurrent-variceal-bleeding-in-a-patient-with-pre-hepatic-portal-vein-thrombosis
#19
Tamara Alempijević, Ana Balović, Aleksandra Pavlović-Marković, Dino Tarabar, Miodrag Krstić, Predrag Miljić, Miloš Bjelović
INTRODUCTION: Bleeding from esophageal varices is a serious medical problem because of the risk of recurrent bleeding and high mortality rate (17-54%). Gastroesophageal varices develop in 50% of cirrhotic patients with portal hypertension, but can also develop in other pre- or post-hepatic causes of portal hypertension. CASE REPORT: We reported a 48-year-old female patient with portal hy- pertension caused by mesenterial vein thrombosis due to congenital thrombophilia...
March 2015: Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review
https://www.readbyqxmd.com/read/25813261/-akromegaly-and-pharmacotherapy
#20
Helena Šiprová, Miroslav Souček
Acromegaly is a rare and serious disease. A successful and rational therapy of acromegaly ought to combine surgery, radiotherapy and pharmacotherapy. The submitted article presents a case of acromegaly that was only diagnosed at the stage when total pituitary adenoma removal was impossible. Even so, the long-term stabilisation of the disease was reached by way of repeated surgery through transfenoidal and transcranial approach, by linear accelerator radiation therapy and Leksell Gamma Knife radiotherapy and by pharmacotherapy with somatostatin analogon octreotide and growth hormone receptor antagonist pegvisomant...
February 2015: Vnitr̆ní Lékar̆ství
keyword
keyword
93249
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"