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Wolfgang Hasemann, Florian F Grossmann, Rahel Stadler, Roland Bingisser, Dieter Breil, Martina Hafner, Reto W Kressig, Christian H Nickel
Delirium is frequent in older Emergency Department (ED) patients, but detection rates for delirium in the ED are low. To aid in identifying delirium, we developed and implemented a two-step systematic delirium screening and assessment tool in our ED: the modified Confusion Assessment Method for the Emergency Department (mCAM-ED). Components of the mCAM-ED include: (1) screening for inattention, the main feature of delirium, which was performed with the Months Backwards Test (MBT); (2) delirium assessment based on a structured interview with questions from the Mental Status Questionnaire by Kahn et al...
December 30, 2017: Internal and Emergency Medicine
Hai-Bo Xu, Yong-Xin Li, Yan Li, Newton O Otecko, Ya-Ping Zhang, Bingyu Mao, Dong-Dong Wu
New genes are drivers of evolutionary innovation and phenotypic evolution. Expression of new genes in early development raises the possibility that new genes could originate and be recruited for functions in embryonic development, but this remains undocumented. Here, based on temporal gene expression at different developmental stages in Xenopus tropicalis, we found that young protein-coding genes were significantly enriched for expression in developmental stages occurring after the midblastula transition (MBT), and displayed a decreasing trend in abundance in the subsequent stages after MBT...
December 21, 2017: Journal of Molecular Cell Biology
M Thevenet, C Dondé, R Machabert, L Ancona, C Jost, N Georgieff
Mentalization is a process by which a subject makes sense of both his own mental representations and of those around him. Disturbances in the mentalization process are found in several psychiatric disorders, notably borderline personality disorders for which mentalization-based treatments (MBT) have been developed and evaluated. Children with Autism Spectrum Disorder (ASD) display a theory of mind impairments, which corresponds to disturbances in the mentalization process. Although no MBT protocol for patients with ASD has been described in the literature, such treatment appears promising to improve theory of mind and functional outcome of these children...
December 22, 2017: L'Encéphale
V N Zimina, O E Mikova, T A Varetskaya, D A Oborin, S Yu Degtyareva, V I Sergevnin
AIM: To estimate the detection rate and spectrum of primary drug resistance of Mycobacterium tuberculosis (MBT) in patients with tuberculosis (TB) in relation to their human immunodeficiency virus (HIV) status in a region with high HIV infection rates (the Perm Territory) and to compare of drug-resistant MBT (DR-MBT) in patients with HIV/TB co-infection, by using phenotypic and molecular genetic testing (MGT) methods. SUBJECTS AND METHODS: The results of sputum bacteriological examination were analyzed in 178 HIV-infected patients and 354 non-HIV-infected individuals with a TB diagnosis made in the period July 1, 2014 to August 1, 2015...
2017: Terapevticheskiĭ Arkhiv
Tzu-Yang Weng, Chia-Jung Li, Chung-Yen Li, Yu-Hsuan Hung, Meng-Chi Yen, Yu-Wei Chang, Yu-Hung Chen, Yi-Ling Chen, Hui-Ping Hsu, Jang-Yang Chang, Ming-Derg Lai
Clec4a has been reported to be an immune suppressor of dendritic cells (DCs), but its potential role in cancer therapy remains to be elucidated. The present study investigated whether downregulating the expression of Clec4a via skin delivery of small hairpin RNA (shRNA) using a gene gun produced stronger host immunity and inhibited tumor progression in animal models. Administration of Clec4a2 shRNA delayed tumor growth in both mouse bladder and lung tumor-bearing mouse models. The result was further confirmed with a compensation experiment showing that the antitumor effects induced by Clec4a2 shRNA were restored by co-injection of a plasmid expressing exogenous Clec4a2...
December 15, 2017: Molecular Therapy. Nucleic Acids
Bahri Gjinovci, Kemal Idrizovic, Ognjen Uljevic, Damir Sekulic
There is an evident lack of studies on the effectiveness of plyometric- and skill-based-conditioning in volleyball. This study aimed to evaluate effects of 12-week plyometric- and volleyball-skill-based training on specific conditioning abilities in female volleyball players. The sample included 41 high-level female volleyball players (21.8 ± 2.1 years of age; 1.76 ± 0.06 cm; 60.8 ± 7.0 kg), who participated in plyometric- (n = 21), or skill-based-conditioning-program (n = 20). Both programs were performed twice per week...
December 2017: Journal of Sports Science & Medicine
Folarin A Oguntoyinbo, Margo Cnockaert, Gyu-Sung Cho, Jan Kabisch, Horst Neve, Wilhelm Bockelmann, Mareike Wenning, Charles M A P Franz, Peter Vandamme
A Gram-stain-negative, rod-shaped Proteobacteria isolate, MBT G8648T, was obtained from an acid curd cheese called Quargel. The isolate was moderately salt tolerant and motile, with numerous peritrichous flagella. The 16S rRNA gene sequence analysis indicated that the strain belongs to the genus Halomonas, with 98.42 % 16S rRNA gene sequence similarity with Halomonas titanicae BH1T as nearest related neighbour. Further comparative sequence analysis of secA and gyrB genes, as well as physiological and biochemical tests, revealed that this bacterium formed a taxon well-separated from its nearest neighbours and other established Halomonas species...
December 12, 2017: International Journal of Systematic and Evolutionary Microbiology
Cecilia Lanny Winata, Maciej Łapiński, Leszek Pryszcz, Candida Vaz, Muhammad Hisyam Bin Ismail, Srikanth Nama, Hajira Shreen Hajan, Serene Gek Ping Lee, Vladimir Korzh, Prabha Sampath, Vivek Tanavde, Sinnakaruppan Mathavan
In the earliest stages of animal development following fertilization, maternally deposited mRNAs direct biological processes to the point of zygotic genome activation (ZGA). These maternal mRNAs undergo cytoplasmic polyadenylation (CPA), suggesting translational control of their activation. To elucidate the biological role of CPA during embryogenesis, we performed genome-wide polysome profiling at several stages of zebrafish development. Our analysis revealed a correlation between CPA and polysome-association dynamics, demonstrating a coupling of translation to the CPA of maternal mRNAs...
January 8, 2018: Development
Bo Rao, Tong Zhao, Sha Yang, Jinsong Chai, Yiting Pan, Shiyin Weng, Haizhu Yu, Xiaowu Li, Manzhou Zhu
A novel Au36-xCux(m-MBT)24 (x = 1-3, m-MBT = 3-methylbenzenethiolate) nanocluster has been prepared. According to the X-ray single crystal diffractometer, the structure of Au36-xCux(m-MBT)24 is similar to that of Au36(SPhtBu)24. The Au36-xCux(m-MBT)24 nanocluster contains a face-centered cubic (FCC) M28 core, which is protected by 4 M2S3 (M = Au/Cu) staple motifs and 12 bridging SR ligands. The Cu dopants could possibly occupy 14 sites (six in the sub-surface and eight in the staple motifs). Spectral monitoring indicates that the number of Cu dopants sequentially increased on increasing the amount of Cu precursors (relative to a Au control)...
December 11, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
Tawfik A Saleh, Saddam A Al-Hammadi, Abdulkadir Tanimu, Khalid Alhooshani
The role of cobalt and molybdenum nanoparticles loaded on activated carbon (AC) on the adsorptive desulfurization ability of sulfur-containing compounds was investigated under ambient conditions. The AC was first synthesized and activated, followed by incorporation of the cobalt (Co), molybdenum (Mo) and both Co and Mo nanoparticles. The adsorption activity parameters of the developed composites were determined using surface characterization and N2 physisorption techniques. The prepared composites were evaluated for simultaneous adsorption of sulfur compounds from fuels...
November 27, 2017: Journal of Colloid and Interface Science
Jahir Antonio Batista-Andrade, Sergiane Souza Caldas, Rodrigo Moço Batista, Italo Braga Castro, Gilberto Fillmann, Ednei Gilberto Primel
Antifouling biocides in surface sediments and gastropod tissues were assessed for the first time along coastal areas of Panama under the influence of maritime activities, including one of the world's busiest shipping zones: the Panama Canal. Imposex incidence was also evaluated in five muricid species distributed along six coastal areas of Panama. This TBT-related biological alteration was detected in three species, including the first report in Purpura panama. Levels of organotins (TBT, DBT, and MBT) in gastropod tissues and surficial sediments ranged from <5 to 104 ng Sn g-1 and <1-149 ng Sn g-1, respectively...
November 24, 2017: Environmental Pollution
Teresa Alonso-Rasgado, Qing-Hang Zhang, David Jimenez-Cruz, Colin Bailey, Elizabeth Pinder, Avanthi Mandaleson, Sumedh Talwalkar
Chronic scapholunate ligament (SL) injuries are difficult to treat and can lead to wrist dysfunction. Whilst several tendon reconstruction techniques have been employed in the management of SL instability, SL gap reappearance after surgery has been reported. Using a finite element model and cadaveric study data, we investigated the performance of the Corella, scapholunate axis (SLAM) and modified Brunelli tenodesis (MBT) techniques. Scapholunate dorsal and volar gap and angle were obtained following virtual surgery undertaken using each of the three reconstruction methods with the wrist positioned in flexion, extension, ulnar deviation and radial deviation, in addition to the ulnar-deviated clenched fist and neutral positions...
November 25, 2017: Medical & Biological Engineering & Computing
Jackie Mclennan, Jason Smith, Kevin Mackway-Jones
BACKGROUND: The predominant cause of preventable death from trauma is bleeding. Many patients need resuscitation with massive blood transfusion (MBT). In some theatres of military operation there is limited blood product availability and walking donor panels can be required. This study aimed to produce a tool to predict the need for MBT using information available on patient arrival at the ED for patients sustaining battlefield trauma. METHODS: A retrospective database analysis was undertaken using the UK Joint Theatre Trauma Registry (JTTR) to provide derivation and validation datasets...
December 2017: Emergency Medicine Journal: EMJ
Jaime Fernandez-Fernandez, Urs Granacher, David Sanz-Rivas, Jose Manuel Sarabia Marín, Jose Luis Hernandez-Davo, Manuel Moya
Fernandez-Fernandez, J, Granacher, U, Sanz-Rivas, D, Sarabia Marín, JM, Hernandez-Davo, JL, and Moya, M. Sequencing effects of neuromuscular training on physical fitness in youth elite tennis players. J Strength Cond Res XX(X): 000-000, 2017-The aim of this study was to analyze the effects of a 5-week neuromuscular training (NMT) implemented before or after a tennis session in prepubertal players on selected components of physical fitness. Sixteen elite and well-trained tennis players with a mean age of 12...
November 14, 2017: Journal of Strength and Conditioning Research
Russell F Cole, Graham A Mills, Michelle S Hale, Ruth Parker, Thi Bolam, Peter R Teasdale, William W Bennett, Gary R Fones
Organotins present a toxicological risk to biota in the aquatic environment. Understanding the behaviour of these compounds in sediment is challenging, with sophisticated analytical techniques required for their measurement. We investigated the use of silica-bound sorbents for diffusive gradients in thin-films (DGT) adsorption gels to pre-concentrate five organotins (monobutlytin (MBT), dibutyltin (DBT), tributyltin (TBT), diphenyltin (DPhT), triphenyltin (TPhT)) found frequently in coastal sediment. C8 sorbent showed optimum performance in uptake and recovery of organotins for pH and ionic strength ranges typical of coastal waters...
February 1, 2018: Talanta
Hamdy A Hassan
Tributyltin (TBT) used in a variety of industrial processes, subsequent discharge into the environment, its fate, toxicity and human exposure are topics of current concern. TBT degradation by alkaliphilic bacteria may be a key factor in the remediation of TBT in high pH contaminated sites. In this study, Stenotrophomonas chelatiphaga HS2 were isolated and identified from TBT contaminated site in Mediterranean Sea. S. chelatiphaga HS2 has vigor capability to transform TBT into dibutyltin and monobutyltin (DBT and MBT) at pH 9 and 7% NaCl (w/v)...
November 7, 2017: International Journal of Biological Macromolecules
Jui-Tung Liu, Lisa J Bain
Chronic arsenic exposure can result in adverse development effects including decreased intellectual function, reduced birth weight, and altered locomotor activity. Previous in vitro studies have shown that arsenic inhibits stem cell differentiation. MicroRNAs (miRNAs) are small non-coding RNAs that regulate multiple cellular processes including embryonic development and cell differentiation. The purpose of this study was to examine whether altered miRNA expression was a mechanism by which arsenic inhibited cellular differentiation...
November 7, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
Jun-Min Gao, Xiao-Ling Chen, Xiu-Qian Sun, Ke Zhang, You-Peng Chen, Jin-Song Guo, Yu Shen
Organotins (OTs) pollution in the aquatic environment of the Three Gorges Reservoir (TGR) was assessed during the reservoir's operating cycle. Butyltins (BTs) and phenyltins (PhTs) in the water phase and suspended particulate matter (SPM) at different water levels were analysed. It was found that the distribution of OTs in the surface and bottom water phases were similar, with the dominant OTs being BTs at the low water level and PhTs at the high water level. The detection rates and concentrations of OTs in the water phase at the high water level were both higher than those at the low water level, with most OTs being monobutyltin (MBT) at the low water level and monophenyltin (MPhT) at the high water level...
November 3, 2017: Environmental Science and Pollution Research International
Frederik Petri Svenningsen, Emma Kaalund, Tine Åkær Christensen, Per Hedeager Helsinghoff, Nanett Yoo-Jin-Bruun Gregersen, Uwe Gustav Kersting, Anderson Souza Oliveira
Load carriage can be harmful for workers, and alternative interventions to reduce back pain while walking and carrying loads are necessary. Unstable shoes have been used to improve balance and reduce back pain, but it is unknown whether walking wearing unstable shoes while carrying loads anteriorly causes excessive trunk extensors muscle activation. The aim of this study was to investigate the effects of different shoe types and anterior load carriage on gait kinematics and lumbar electromyographic (EMG) activity...
October 28, 2017: Human Movement Science
Shobha Sundareswaran, Ravisankar Vijayan
AIM: To prospectively evaluate soft and hard tissue responses to orthodontic treatment of bimaxillary protrusion (BMP) in Dravidian population using McLaughlin, Bennett, and Trevisi (MBT) mechanics of the preadjusted edgewise appliance. METHODS: Thirty-one adult (18-30 years) Class I BMP patients were treated using the above mechanics after extraction of four first premolars. Forty-five pre- and post-treatment variables on lateral cephalograms were compared using paired t-test and Pearson's correlation coefficient...
September 2017: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
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