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Charles A Seller, Patrick H O'Farrell
In preparation for dramatic morphogenetic events of gastrulation, rapid embryonic cell cycles slow at the mid-blastula transition (MBT). In Drosophila melanogaster embryos, down-regulation of cyclin-dependent kinase 1 (Cdk1) activity initiates this slowing by delaying replication of heterochromatic satellite sequences and extending S phase. We found that Cdk1 activity inhibited the chromatin association of Rap1 interacting factor 1 (Rif1), a candidate repressor of replication. Furthermore, Rif1 bound selectively to satellite sequences following Cdk1 down-regulation at the MBT...
May 10, 2018: PLoS Biology
Geoffrey de Brouwer, De Wet Wolmarans
Animal models of human psychiatric illness are valuable frameworks to investigate the etiology and neurobiology underlying the human conditions. Accurate behavioral measures that can be used to characterize animal behavior, thereby contributing to a model's validity, are crucial. One such measure, i.e. the rodent marble-burying test (MBT), is often applied as a measure of anxiety- and compulsive-like behaviors. However, the test is characterized by noteworthy between-laboratory methodological differences and demonstrates positive treatment responses to an array of pharmacotherapies that are often of little translational value...
April 22, 2018: Behavioural Processes
Zhixin Lei, Qianying Liu, Bing Yang, Haseeb Khaliq, Saeed Ahmed, Bowen Fan, Jiyue Cao, Qigai He
The current study evaluates a tested marbofloxacin tablet (MBT) (Petsen), in terms of bioavailability and pharmacokinetics (PK) in a comparison of the commercialized and standard tablet (Marbocyl) in beagle dogs. Four different bacterial species were selected for the determination of the minimal inhibitory concentration (MIC) against marbofloxacin (MBF). Target animal safety studies were conducted with a wide spectrum of dosages of Petsen. Pharmacokinetics and bioavailability of Petsen were observed after the oral administration of a recommended dosage of 2 mg/kg...
2018: Frontiers in Pharmacology
Feng Leng, Jiekai Yu, Chunxiao Zhang, Salvador Alejo, Nam Hoang, Hong Sun, Fei Lu, Hui Zhang
Many non-histone proteins are lysine methylated and a novel function of this modification is to trigger the proteolysis of methylated proteins. Here, we report that the methylated lysine 142 of DNMT1, a major DNA methyltransferase that preserves epigenetic inheritance of DNA methylation patterns during DNA replication, is demethylated by LSD1. A novel methyl-binding protein, L3MBTL3, binds the K142-methylated DNMT1 and recruits a novel CRL4DCAF5 ubiquitin ligase to degrade DNMT1. Both LSD1 and PHF20L1 act primarily in S phase to prevent DNMT1 degradation by L3MBTL3-CRL4DCAF5 ...
April 24, 2018: Nature Communications
H J Welstead, J Patrick, T C Russ, G Cooney, C M Mulvenna, C Maclean, A Polnay
Aims and methodCaring for patients with personality disorder is one of the biggest challenges in psychiatric work. We investigated whether mentalisation-based treatment skills (MBT-S) teaching improves clinicians' understanding of mentalising and attitudes towards personality disorder. Self-report questionnaires (Knowledge and Application of MBT (KAMQ) and Attitudes to Personality Disorder (APDQ)) were completed at baseline and after a 2-day MBT-S workshop. RESULTS: Ninety-two healthcare professionals completed questionnaires before and after training...
April 23, 2018: BJPsych Bulletin
Jarno van Roosmalen, Freek J Beekman, Marlies C Goorden
Recently, we proposed and optimized dedicated multi-pinhole molecular breast tomosynthesis (MBT) that images a lightly compressed breast. As MBT may also be performed with other types of collimators, the aim of this paper is to optimize MBT with fan beam and slit-slat collimators and to compare its performance to that of multi-pinhole MBT to arrive at a truly optimized design. Using analytical expressions, we first optimized fan beam and slit-slat collimator parameters to reach maximum sensitivity at a series of given system resolutions...
April 20, 2018: Physics in Medicine and Biology
Martina Salzano de Luna, Giovanna Giuliana Buonocore, Chiara Giuliani, Elena Messina, Gabriella Di Carlo, Marino Lavorgna, Luigi Ambrosio, Gabriel M Ingo
The photodegradation kinetics of 2-mercaptobenzothiazole (MBT), a corrosion inhibitor for copper-based alloys, is studied for the first time in high amorphous polyvinyl alcohol coatings subjected to either UV irradiation or indoor light exposure. The photodegradation process proceeds rapidly, thus compromising the anticorrosion ability of the coating. We prove that the encapsulation of MBT into layered double hydroxide (LDH) nanocarriers slows down its decomposition kinetics by a factor 3. Besides preserving the corrosion inhibitor, such a strategy allows a controlled release of MBT triggered by corrosion-related stimuli, e...
April 17, 2018: Angewandte Chemie
Sami Hassan, Daniel Thurston, Tanvir Sian, Rohi Shah, Abdul Aziz, Paresh Kothari
The modified Broström technique (MBT) is considered the reference standard for surgical management of ankle instability, with good short-term outcomes. However, limited evidence is available regarding outcomes for delayed presentations of instability. We report our outcomes for patients who underwent ligament repair using the MBT, from a single-surgeon retrospective study of consecutive patients. The minimum postoperative follow-up period was 6 months during a 5-year study period. The patients were retrospectively divided into 3 groups according to the delay in presentation: group 1, 6 months to 2 years; group 2, 2 to 4 years; and group 3, >4 years...
April 11, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
Gregor Fiedler, Erik Brinks, Christina Böhnlein, Gyu-Sung Cho, Sabrina Koberg, Jan Kabisch, Charles M A P Franz
The genome of the intimin ( eae )-harboring Escherichia albertii strain MBT-EA1, isolated from lettuce in Germany, was sequenced. Sequence analysis showed the assembled draft genome size to be 4,560,948 bp, containing a predicted total of 4,414 protein-encoding genes, 11 rRNAs, and 82 tRNAs. Furthermore, three plasmid sequences were found.
April 12, 2018: Genome Announcements
M Cordovana, M Kostrzewa, J Sóki, E Witt, S Ambretti, A B Pranada
Bacteroides fragilis is a frequent anaerobic pathogen and can cause severe infections. Resistance to carbapenems, associated with the cfiA gene encoded carbapenemase, represents an emerging problem. To date, no rapid methods are available to detect and confirm this resistance mechanism in routine laboratories, and the missed recognition of carbapenemase-producing strains can lead to therapeutic failures. In this study we have investigated a whole MALDI-TOF MS-based workflow to detect carbapenemase-producing B...
April 4, 2018: Anaerobe
Rui Lin, Yufeng Wang, Quanning Chen, Zhongyan Liu, Shuai Xiao, Bingyi Wang, Baomin Shi
The aim of the present study was to investigate transient receptor potential cation channel subfamily M member 2 (TRPM2), a promising therapeutic target and biomarker for pancreatic ductal adenocarcinoma (PDAC) prognosis, in addition to determining its effects regarding tumor progression and invasion. PDAC is a fatal disease with a poor prognosis, and its associated pathogenic molecular mechanisms remain to be determined. In the present study, combined analysis using genomic and transcriptomic data from two PDAC studies was performed to discover a survival‑associated biomarker of PDAC...
March 28, 2018: Molecular Medicine Reports
Cristina Aracil, Pedro Haro, Diego Fuentes-Cano, Alberto Gómez-Barea
The economic and environmental impact of several waste-to-energy (WtE) schemes to produce electricity from municipal solid waste (MSW) refuse is evaluated and compared with landfill disposal. Both incineration and gasification alternatives are considered. The gasification option includes three different configurations: (1) a fluidized bed gasifier (FBG) with internal combustion engine (ICE), (2) a FBG with organic Rankine cycle (ORC) and (3) a grate gasifier with steam Rankine cycle (SRC). The study is primarily applied to regions where the management system is based on Mechanical Biological Treatment (MBT) plants, generating a large share of refuse (>70%), which is currently landfilled...
March 30, 2018: Waste Management
Hamdy A Hassan, Somya E Dawah, Mostafa M El-Sheekh
Tributyltin (TBT) is recognized as a major environmental problem at a global scale. Haloalkaliphilic tributyltin (TBT)-degrading bacteria may be a key factor in the remediation of TBT polluted sites. In this work, three haloalkaliphilic bacteria strains were isolated from a TBT-contaminated site in the Mediterranean Sea. After analysis of the 16S rRNA gene sequences the isolates were identified as Sphingobium sp. HS1, Stenotrophomonas chelatiphaga HS2 and Rhizobium borbori HS5. The optimal growth conditions for biodegradation of TBT by the three strains were pH 9 and 7% (w/v) salt concentration...
March 28, 2018: Revista Argentina de Microbiología
Elfrida Hartveit Kvarstein, Geir Pedersen, Espen Folmo, Øyvind Urnes, Merete Selsbakk Johansen, Benjamin Hummelen, Theresa Wilberg, Sigmund Karterud
OBJECTIVES: Mentalization-based treatment (MBT), originally designed for patients with borderline personality disorder (BPD), may be particularly indicated for severe conditions. However, there is limited documentation of how increasing severity of personality disorder (PD) effect outcomes of highly specialized treatments. This study aimed to investigate associations between clinical severity and outcomes for patients in MBT as compared to a psychodynamic group-based treatment programme (PDT)...
March 26, 2018: Psychology and Psychotherapy
Xiangyun Li, Xiangxiang Zhu, Chong Xu, Jianhua Wu
2-Methyl-2-butanol (MBT) is a chemical compound from the group of alcohols more specifically pentanols, which has shown an excellent anti-cancer activity in our previous study. However, its mechanism of action remains unclear. The present study was designed to investigate the anti-cancer effect of MBT on human retinoblastoma cells. The results showed that the use of MBT leads to HXO-RB44 cell death but is cytotoxic to normal cells at higher concentrations. It showed a dose- as well as a time-dependent inhibition of HXO-RB44 cells...
March 15, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
Bernd Zimmer, Hiba Sino
PURPOSE: To analyze common values of bracket torque (Andrews, Roth, MBT, Ricketts) for their validity in achieving incisor inclinations that are considered normal by different cephalometric standards. METHODS: Using the equations developed in part 1 (eU1(BOP) = 90° - BT(U1) - TCA(U1) + α1 - α2 and eL1(BOP) = 90° - BT(L1) - TCA(L1) + β1 - β2 ) (abbreviations see part 1) and the mean values (± SD) obtained as statistical measures in parts 1 and 2 of the study (α1 and β1 [1...
March 19, 2018: Journal of Orofacial Orthopedics, Fortschritte der Kieferorthopädie
Ting Deng, Lei Wu, Jun-Min Gao, Bin Zhou, Ya-Li Zhang, Wen-Nan Wu, Zhuo-Heng Tang, Wen-Chao Jiang, Wei-Lin Huang
The occurrence and health risks of organotins (OTs) in the waterworks and source water in the Three Gorges Reservoir Region (TGRR), China were assessed in this study. Water samples were collected at four waterworks (A, B, C, and D) in March and July 2012 to analyze butyltins (BTs) and phenyltins (PTs) using a gas chromatography-mass spectrometry (GC-MS) system. Our results showed that both the waterworks and their nearby water sources were polluted by OTs, with PTs being the most dominant species. Monobutyltin (MBT), monophenyltin (MPT), diphenyltin (DPT), and triphenyltin (TPT) were detected in most of the analyzed water samples...
March 18, 2018: Environmental Science and Pollution Research International
Xueting Yan, Bin He, Lihong Liu, Guangbo Qu, Jianbo Shi, Chunyang Liao, Ligang Hu, Guibin Jiang
Organotin compounds (OTs) are used in a range of industrial products, such as antifouling paints, agricultural pesticides and stabilizers. Owing to potential endocrine-disrupting effects, human exposure to such compounds is a concern. Nevertheless, little is known about the adverse effect of OTs on adrenocortical function in organisms. In this study, the human adrenocortical carcinoma cell (H295R) model was used to investigate effects of OTs on steroidogenesis and potential causes for such endocrine disruption was examined...
July 30, 2018: Ecotoxicology and Environmental Safety
Bernd Zimmer, Hiba Sino
PURPOSE: The objective of this investigation was to develop equations to describe the geometric relations among "targeted incisor inclinations" (tU1, tL1) accommodating different cephalometric norms (Ricketts, Bergen, etc.) with the "expected inclinations" (eU1, eL1), as they can be generated by bracket torque values according to Andrews, Roth, Ricketts, and MBT. METHODS: In its key parts, the present study is a theoretical work in which structural relationships are described using standard mathematical and geometric methodologies...
May 2018: Journal of Orofacial Orthopedics, Fortschritte der Kieferorthopädie
Kian F Wong, James Teng, Michael W L Chee, Kinjal Doshi, Julian Lim
Mindfulness based training (MBT) is becoming increasingly popular as a means to improve general wellbeing through developing enhanced control over metacognitive processes. In this preliminary study, we tested a cohort of 36 nurses (mean age = 30.3, SD = 8.52; 2 male) who participated in an 8-week MBT intervention to examine the improvements in sustained attention and its energetic costs that may result from MBT. Changes in sustained attention were measured using the psychomotor vigilance task (PVT) and electroencephalography (EEG) was collected both during PVT performance, and during a brief period of meditation...
2018: Frontiers in Human Neuroscience
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